Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons

Neuron

Volumn 27, Issue 3, 2000, Pages 499-512

  Kuruvilla, Rejji ^a   Ye, Haihong ^a   Ginty, David D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CELLULAR DISTRIBUTION; EMBRYO; ENZYME ACTIVITY; NERVE CELL DIFFERENTIATION; NERVE FIBER; NEWBORN; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SYMPATHETIC NERVE CELL;

EID: 0033695838     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)00061-1     Document Type: Article

References (39)

1. Essential role of the dynamin pleckstrin homology domain in receptor-mediated endocytosis
2. In sympathetic but not sensory neurones, phosphoinositide-3 kinase is important for NGF-dependent survival and the retrograde transport of 125l-betaNGF
3. K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity
4. Local control of neurite development by nerve growth factor
5. Phosphotidylinositol 3-kinase and AKT protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
6. Cellular survival: A play in three Akts
7. Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits
8. Endocytosis of activated TrkA: Evidence that nerve growth factor induces formation of signaling endosomes
9. A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA
10. The retrograde axonal transport of nerve growth factor
11. Characterization of the retrograde transport of nerve growth factor (NGF) using high specific activity [125l]NGF
12. Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites
13. Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking
14. Signal transduction by the neurotrophin receptors
15. Neurotrophin signal transduction in the nervous system
16. Quantitative demonstration of the retrograde axonal transport of endogenous nerve growth factor
17. Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Clambda do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription
18. Nerve growth factor modulates synaptic transmission between sympathetic neurons and cardiac myocytes
19. Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway
20. Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance
21. Retrograde transport of endogenous nerve growth factor in superior cervical ganglion of adult rats
22. Inhibition of the cellular actions of nerve growth factor by staurosporine and K252a results from the attenuation of the activity of the trk tyrosine kinase
23. Demonstration of retrogradely transported endogenous nerve growth factor in axons of sympathetic neurons
24. Development of sensory neurons in the absence of NGF/TrkA signaling in vivo
25. Activated phosphatidylinositol 3-kinase promotes survival of superior cervical neurons
26. Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase
27. Neurotrophic factors and their receptors: Roles in neuronal development and function
28. An NGF-TrkA-Mediated retrograde signal to transcription factor CREB in sympathetic neurons
29. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
30. Synergistic role of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase cascade in the regulation of insulin receptor trafficking
31. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
32. Comparison between the retrograde axonal transport of nerve growth factor and tetanus toxin in motor, sensory and adrenergic neuro
33. K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptor
34. Characterization of an NGF-P-TrkA retrograde signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons
35. Phosphatidylinositol 3-kinase is required for the trophic, but not the survival-promoting, actions of NGF on sympathetic neurons
36. Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival
37. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
38. Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complexes
39. Requirement for phosphatidylinositol-3-kinase in the prevention of apoptosis by nerve growth factor