-
3
-
-
0032080309
-
Stable complexes involving acetylcholinesterase and amyloid-β peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils
-
(1998)
J Neurosci
, vol.18
, pp. 3213-3223
-
-
Alvarez, A.1
Alarcón, R.2
Opazo, C.3
Campos, E.O.4
Munoz, F.J.5
Calderón, F.H.6
Dajas, F.7
Gentry, M.K.8
Doctor, B.P.9
De Mello, F.G.10
Inestrosa, N.C.11
-
10
-
-
0031278270
-
Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
-
(1997)
Nat Genet
, vol.17
, pp. 263-264
-
-
Bales, K.R.1
Verina, T.2
Dodel, R.C.3
Du, Y.4
Altstiel, L.5
Bender, M.6
Hyslop, P.7
Johnstone, E.M.8
Little, S.P.9
Cummins, D.J.10
Piccardo, P.11
Ghetti, B.12
Paul, S.M.13
-
11
-
-
0031108103
-
Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch, signalling independently of proteolytic processing
-
(1998)
Genes and Function
, vol.1
, pp. 149-159
-
-
Baumeister, R.1
Leimer, U.2
Zweckbronner, I.3
Jackubek, C.4
Grünberg, J.5
Haass, C.6
-
14
-
-
0031593606
-
Simulation of cortical cholinergic deficits - A novel experimental approach to study pathogenetic aspects of Alzheimer's disease
-
(1998)
J Neural Transm
, vol.54
, pp. 237-247
-
-
Bigl, V.1
Schliebs, R.2
-
15
-
-
17344362232
-
Alpha-2 macroglobulin is genetically associated with Alzheimer's disease
-
(1998)
Nat Genet
, vol.19
, pp. 357-360
-
-
Blacker, D.1
Wilcox, M.A.2
Laird, N.M.3
Rodes, L.4
Horvath, S.M.5
Go, R.C.6
Perry, R.7
Watson B., Jr.8
Bassett, S.S.9
McInnis, M.G.10
Albert, M.S.11
Hyman, B.T.12
Tanzi, R.E.13
-
17
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
18
-
-
0030833055
-
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
-
(1997)
Neuron
, vol.19
, pp. 939-945
-
-
Borchelt, D.R.1
Ratovitsky, T.2
Van Lare, J.3
Lee, M.K.4
Gonzales, V.5
Jenkins, N.A.6
Copeland, N.G.7
Price, D.L.8
Sisodia, S.S.9
-
24
-
-
0032558784
-
Amyloid plaques and neuron death in APP transgenic mice
-
(1998)
Nature
, vol.395
, pp. 755-756
-
-
Calhoun, M.E.1
Wiederhold, K.-H.2
Abramowski, D.3
Phinney, A.L.4
Probst, A.5
Sturchler-Pierrat, C.6
Staufenbiel, M.7
Sommer, B.8
Jucker, M.9
-
25
-
-
0032555718
-
Roles for proteolysis and trafficking in Notch maturation and signal transduction
-
(1998)
Cell
, vol.94
, pp. 423-426
-
-
Chan, Y.-M.1
Jan, Y.N.2
-
26
-
-
0026075602
-
Early-onset Alzheimer's disease caused by mutations at codon 717 of β-amyloid precursor protein gene
-
(1991)
Nature
, vol.353
, pp. 844-846
-
-
Chartier-Harlin, M.1
Crawford, F.2
Houlden, H.3
Warren, A.4
Hughes, D.5
Fidani, L.6
Goate, A.7
Rossor, M.8
Roques, P.9
Hardy, J.10
Mullan, M.11
-
28
-
-
0032895651
-
Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation
-
(1999)
Nat Med
, vol.5
, pp. 560-564
-
-
Chui, D.-H.1
Tanahashi, H.2
Ozawa, K.3
Ikeda, S.4
Checler, F.5
Ueda, O.6
Suzuki, H.7
Araki, W.8
Inoue, H.9
Shirotani, K.10
Takahashi, K.11
Gallyas, F.12
Tabira, T.13
-
29
-
-
0026745610
-
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
-
(1992)
Nature
, vol.360
, pp. 672-674
-
-
Citron, M.1
Oltersdorf, T.2
Haass, C.3
McConlogue, L.4
Hung, A.5
Seubert, P.6
Vigo-Pelfrey, C.7
Lieberburg, I.8
Selkoe, D.9
-
30
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
-
(1997)
Nat Med
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.S.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
Kholodenko, D.11
Motter, R.12
Sherrington, R.13
Perry, B.14
Yao, H.15
Strome, R.16
Lieberburg, I.17
Rommens, J.18
Kim, S.19
Schenk, D.20
Fraser, P.21
St. George Hyslop, P.22
Selkoe, D.J.23
more..
-
32
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late-onset families
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
Roses, A.D.7
Haines, J.L.8
Pericak-Vance, M.A.9
-
33
-
-
0028305380
-
Apolipoprotein E type 2 allele decreases the risk of late-onset Alzheimer's disease
-
(1994)
Nat Genet
, vol.7
, pp. 180-184
-
-
Corder, E.H.1
Saunders, A.M.2
Risch, N.J.3
Strittmatter, W.J.4
Schmechel, D.E.5
Gaskell, P.C.6
Rimmler, J.B.7
Locke, P.A.8
Conneally, K.E.9
Schmader, K.E.10
Small, G.W.11
Roses, A.D.12
Haines, J.L.13
Pericak-Vance, M.A.14
-
36
-
-
0032880253
-
Association between Alzheimer's disease and NOS3 gene
-
(1999)
Ann Neurol
, vol.46
, pp. 664-667
-
-
Dahiyat, M.1
Cumming, A.2
Harrington, C.3
Wischik, C.4
Xuereb, J.5
Corrigan, F.6
Breen, G.7
Shaw, D.8
St. Clair, D.9
-
37
-
-
0033017690
-
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein
-
(1999)
Neuroscience
, vol.90
, pp. 1-13
-
-
Dawson, G.R.1
Seabrook, G.R.2
Zheng, H.3
Smith, D.W.4
Graham, S.5
O'Dowd, G.6
Bowery, B.J.7
Boyce, S.8
Trumbauer, M.E.9
Chen, H.Y.10
Van der Ploeg, L.H.T.11
Sirinathsinghji, D.J.S.12
-
38
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
39
-
-
0033535504
-
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
Mumm, J.S.6
Schroeter, E.H.7
Schrijvers, V.8
Wolfe, M.S.9
Ray, W.J.10
Goate, A.11
Kopan, R.12
-
40
-
-
16044366039
-
Increased amyloid-β 42(43) in brains of mice expressing mutant presenilin 1
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
41
-
-
0033569760
-
Activation of the L-voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to β-amyloid
-
(1999)
J Biol Chem
, vol.274
, pp. 30322-30327
-
-
Ekinci, F.J.1
Malik, K.U.2
Shea, T.B.3
-
43
-
-
0025295039
-
Cleavage of amyloid peptide during constitutive processing of its precursor
-
(1990)
Science
, vol.248
, pp. 1122-1124
-
-
Esch, F.S.1
Keim, P.S.2
Beattie, E.C.3
Blacher, R.W.4
Culwell, A.R.5
Oltersdorf, T.6
McClure, D.7
Ward, P.J.8
-
44
-
-
0024317904
-
Prevalence of Alzheimer's disease in a community population of older persons
-
(1989)
JAMA
, vol.262
, pp. 2551-2556
-
-
Evans, D.A.1
Funkenstein, H.2
Albert, M.S.3
Scherr, P.A.4
Cook, N.R.5
Chown, M.J.6
Hebert, L.E.7
Hennekens, C.H.8
Taylor, J.O.9
-
50
-
-
0032531845
-
Protease inhibitor coinfusion with amyloid β-protein results in enhanced deposition and toxicity in rat brain
-
(1998)
J Neurosci
, vol.18
, pp. 8311-8321
-
-
Frautschy, S.A.1
Horn, D.L.2
Sigel, J.J.3
Harris-White, M.E.4
Mendoza, J.J.5
Yang, F.6
Saido, T.C.7
Cole, G.M.8
-
55
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
Barbour, R.4
Berthelette, P.5
Blackwell, C.6
Carr, T.7
Clemens, J.8
Donaldson, T.9
Gillespie, F.10
Guido, T.11
Hagopian, S.12
Johnson-Wood, K.13
Khan, K.14
Lee, M.15
Leibowitz, P.16
Lieberburg, I.17
Little, S.18
Masliah, E.19
McConlogue, L.20
Montoya-Zavala, M.21
Mucke, L.22
Paganini, L.23
Penniman, E.24
Power, M.25
Schenk, D.26
Seubert, P.27
Snyder, B.28
Soriano, F.29
Tan, H.30
Vitale, J.31
Wadsworth, S.32
Wolozin, B.33
Zhao, J.34
more..
-
59
-
-
0028213192
-
Similarities between β amyloid peptides 1-40 and 40-1: Effects on aggregation, toxicity in vitro, and injection in young and aged rats
-
(1994)
Exp Neurol
, vol.125
, pp. 175-182
-
-
Giordano, T.1
Pan, J.B.2
Monteggia, L.M.3
Holzman, T.F.4
Snyder, S.W.5
Krafft, G.6
Ghanbari, H.7
Kowall, N.W.8
-
61
-
-
0029811105
-
Specific domains of β-amyloid from Alzheimer plaques elicit neuron killing in human microglia
-
(1996)
J Neurosci
, vol.16
, pp. 6021-6037
-
-
Giulian, D.1
Haverkamp, L.J.2
Yu, J.3
Karshin, W.4
Tom, D.5
Li, J.6
Kirkpatrick, J.7
Kuo, Y.M.8
Roher, A.E.9
-
62
-
-
0032491435
-
The HHQK domain of β-amyloid provides a structural basis for the immunopathology of Alzheimer's disease
-
(1998)
J Biol Chem
, vol.273
, pp. 29719-29726
-
-
Giulian, D.1
Haverkamp, L.J.2
Yu, J.3
Karshin, W.4
Tom, D.5
Li, J.6
Kazanskaia, A.7
Kirkpatrick, J.8
Roher, A.E.9
-
63
-
-
0023818885
-
Alzheimer's disease: Its proteins and genes
-
(1988)
Cell
, vol.52
, pp. 307-308
-
-
Glenner, G.G.1
-
65
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.-C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
Mant, R.11
Newton, P.12
Rooke, K.13
Roques, P.14
Talbot, C.15
Pericak-Vance, M.16
Roses, A.17
Willamson, R.18
Rossor, M.19
Owen, M.20
Hardy, J.21
more..
-
68
-
-
0028915895
-
Amyloid β protein (Aβ) in Alzheimer's disease brain
-
(1995)
J Biol Chem
, vol.270
, pp. 7013-7016
-
-
Gravina, S.A.1
Ho, L.2
Eckman, C.B.3
Long, K.E.4
Otvos L., Jr.5
Younkin, L.H.6
Suzuki, N.7
Younkin, S.G.8
-
71
-
-
0001626404
-
Long-term treatment of Alzheimer's disease with idebenone
-
K. Iqbal, B. Winblad, T. Nishimura, M. Takeda, & H. M. Wisniewski (Eds.), Alzheimer's Disease: Biology, Diagnosis And Therapeutics. Chichester: Wiley
-
(1997)
, pp. 687-705
-
-
Gutzmann, H.1
Hadler, D.2
Erzigkeit, H.3
-
72
-
-
0026646604
-
Amyloid β-peptide is produced by cultured cells during normal metabolism
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
Ostaszewski, B.L.6
Lieberburg, I.7
Koo, E.H.8
Schenk, D.9
Teplow, D.B.10
Selkoe, D.J.11
-
77
-
-
0031890373
-
24)25-35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation
-
(1998)
Behav Brain Res
, vol.90
, pp. 133-145
-
-
Harkany, T.1
O'Mahony, S.2
Kelly, J.P.3
Soós, K.4
Töro, I.5
Penke, B.6
Luiten, P.G.M.7
Nyakas, C.8
Gulya, K.9
Leonard, B.E.10
-
78
-
-
0033519547
-
Propionyl-IIGL tetrapeptide antagonizes β-amyloid excitotoxicity in rat nucleus basalis
-
(1999)
Neuroreport
, vol.10
, pp. 1693-1698
-
-
Harkany, T.1
Abraham, I.2
Laskay, G.3
Timmerman, W.4
Jost, K.5
Zarandi, M.6
Penke, B.7
Nyakas, C.8
Luiten, P.G.M.9
-
79
-
-
0026879650
-
Presenile dementia and cerebral hemorrhage linked to a mutation at codon 692 of the β-amyloid precursor protein gene
-
(1992)
Nat Genet
, vol.1
, pp. 218-221
-
-
Hendricks, L.1
Van Duijn, C.M.2
Cras, P.3
Cruts, M.4
Van Hul, W.5
Van Harskamp, F.6
Warren, A.7
McInnis, M.G.8
Antonarakis, S.E.9
Martin, J.-J.10
Hofman, A.11
Van Broeckhoven, C.12
-
81
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
(1998)
Nat Med
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
Gordon, M.N.2
McGowan, E.3
Yu, X.4
Benkovic, S.5
Jantzen, P.6
Wright, K.7
Saad, I.8
Mueller, R.9
Morgan, D.10
Sanders, S.11
Zehr, C.12
O'Campo, K.13
Hardy, J.14
Prada, C.-M.15
Eckman, C.16
Younkin, S.17
Hsiao, K.18
Duff, K.19
-
83
-
-
9244245733
-
Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3β in brain
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 2719-2723
-
-
Hoshi, M.1
Takashima, A.2
Noguchi, K.3
Murayama, M.4
Sato, M.5
Kondo, S.6
Saitoh, Y.7
Ishiguro, K.8
Hoshino, T.9
Imahori, K.10
-
84
-
-
0031025045
-
Nontoxic amyloid β peptide 1-42 suppresses acetylcholine synthesis
-
(1997)
J Biol Chem
, vol.272
, pp. 2038-2041
-
-
Hoshi, M.1
Takashima, A.2
Murayama, M.3
Yasutake, K.4
Yoshida, N.5
Ishiguro, K.6
Hoshino, T.7
Imahori, K.8
-
86
-
-
0033563079
-
Inhibition of fibril formation in β-amyloid by a novel series of benzofurans
-
(1999)
Biochem J
, vol.340
, pp. 283-289
-
-
Howlett, D.R.1
Perry, A.E.2
Godfrey, F.3
Swatton, J.4
Jennings, K.H.5
Spitzfaden, C.6
Wadsworth, H.7
Wood, S.J.8
Markwell, R.E.9
-
87
-
-
0028810244
-
Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins
-
(1995)
Neuron
, vol.15
, pp. 1203-1218
-
-
Hsiao, K.1
Borchelt, D.R.2
Olson, K.3
Johannsdottir, R.4
Kitt, C.5
Yunis, W.6
Xu, S.7
Eckman, C.8
Harigaya, Y.9
Younkin, S.10
Yang, F.11
Cole, G.12
-
88
-
-
0029742199
-
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
Yang, F.7
Cole, G.8
-
89
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as β-secretase
-
(1999)
Mol Cell Neurosci
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
Chapman, C.6
Gloger, I.S.7
Murphy, K.E.8
Southan, C.D.9
Ryan, D.M.10
Smith, T.S.11
Simmons, D.L.12
Walsh, F.S.13
Dingwall, C.14
Christie, G.15
-
90
-
-
0032543684
-
Association of missense and 5′-splice site mutations in tau with the inherited dementia FTDP-17
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
Lendon, C.L.2
Rizzu, P.3
Baker, M.4
Froelich, S.5
Houlden, H.6
Pickering-Brown, S.7
Chakraverty, S.8
Isaacs, A.9
Grover, A.10
Hackett, J.11
Adamson, J.12
Lincoln, S.13
Dickson, D.14
Davies, P.15
Petersen, R.C.16
Stevens, M.17
De Graaff, E.18
Wauters, E.19
Van Baren, J.20
Hillebrand, M.21
Joosse, M.22
Kwon, J.M.23
Nowotny, P.24
Che, L.K.25
Norton, J.26
Morris, J.C.27
Reed, L.A.28
Trojanowski, J.29
Basun, H.30
Lannfelt, L.31
Neystat, M.32
Fahn, S.33
Dark, F.34
Tannenberg, T.35
Dodd, P.R.36
Hayward, N.37
Kwok, J.B.J.38
Schofield, P.R.39
Andreadis, A.40
Snowden, J.41
Craufurd, D.42
Neary, D.43
Owen, F.44
Oostra, B.A.45
Hardy, J.46
Goart, A.47
Van Swieten, J.48
Mann, D.49
Lynch, T.50
Heutink, P.51
more..
-
91
-
-
0029863697
-
Acetylcholinesterase accelerates assembly of amyloid-β-peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme
-
(1996)
Neuron
, vol.16
, pp. 881-891
-
-
Inestrosa, N.C.1
Alvarez, A.2
Perez, C.A.3
Moreno, R.D.4
Vicente, M.5
Linker, C.6
Casanueva, O.I.7
Soto, C.8
Garrido, J.9
-
93
-
-
0030611097
-
Aβ deposition is associated with neutrophil changes, but not with overt neuronal loss in the human precursor protein V717F (PDAPP) transgenic mouse
-
(1997)
J Neurosci
, vol.17
, pp. 7053-7059
-
-
Irizarry, M.C.1
Soriano, F.2
McNamara, M.3
Page, K.J.4
Schenk, D.5
Games, D.6
Hyman, B.T.7
-
95
-
-
0030931020
-
Effects of metrifonate on memory impairment and cholinergic dysfunction in rats
-
(1997)
Eur J Pharmacol
, vol.322
, pp. 11-19
-
-
Itoh, A.1
Nitta, A.2
Katono, Y.3
Usui, M.4
Naruhashi, K.5
Iida, R.6
Hasegawa, T.7
Nabeshima, T.8
-
96
-
-
0032754051
-
Impairment of long-term potentiation in hippocampal slices of β-amyloid-infused rats
-
(1999)
Eur J Pharmacol
, vol.382
, pp. 167-175
-
-
Itoh, A.1
Akaike, T.2
Sokabe, M.3
Nitta, A.4
Iida, R.5
Olariu, A.6
Yamada, K.7
Nabeshima, T.8
-
98
-
-
0029982615
-
Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos
-
(1996)
Neurobiol Aging
, vol.17
, pp. 235-241
-
-
James, N.D.1
Davis, D.R.2
Sindon, J.3
Hanger, D.P.4
Brion, J.P.5
Miller, C.C.J.6
Rosenberg, M.P.7
Erton, B.H.8
Propst, F.9
-
99
-
-
0027195933
-
Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
-
(1993)
Cell
, vol.73
, pp. 1055-1058
-
-
Jarrett, J.T.1
Lansbury P.T., Jr.2
-
100
-
-
0345291176
-
Cerebrospinal fluid Aβ42 is increased early in sporadic Alzheimer's disease and declines with disease progression
-
(1999)
Ann Neurol
, vol.45
, pp. 504-511
-
-
Jensen, M.1
Schröder, J.2
Blomberg, M.3
Engvall, B.4
Pantel, J.5
Ida, N.6
Basun, H.7
Wahlund, L.-O.8
Werle, E.9
Jauss, M.10
Beyreuther, K.11
Lannfelt, L.12
Hartmann, T.13
-
101
-
-
0006536451
-
Continuous exposure to β-amyloid protein influences glutathione homeostasis in the rat brain
-
(1999)
Soc Neurosci Abstr
, vol.25
, pp. 341
-
-
Jhoo, W.K.1
Kim, H.C.2
Yamada, K.3
Im, D.H.4
Mirault, M.-E.5
Hjille, O.P.6
Mamiya, T.7
Nabeshima, T.8
-
102
-
-
0031020909
-
Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 1550-1555
-
-
Johnson-Wood, K.1
Lee, M.2
Motter, R.3
Hu, K.4
Gordon, G.5
Barbour, R.6
Khan, K.7
Gordon, M.8
Tan, H.9
Games, D.10
Lieberburg, I.11
Schenk, D.12
Seubert, P.13
McConlogue, L.14
-
104
-
-
0026443727
-
Deposition of β/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxy-terminal fragment of the Alzheimer amyloid precursor in the brain
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 10857-10861
-
-
Kammesheidt, A.1
Boyce, F.M.2
Spannoyannis, A.F.3
Cummings, B.J.4
Ortegon, M.5
Cotman, C.6
Vaught, J.L.7
Neve, R.L.8
-
105
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell surface receptor
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.-G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
109
-
-
0029900084
-
Amyloid β-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 6753-6758
-
-
Kelly, J.F.1
Furukawa, K.2
Barger, S.W.3
Rengen, M.R.4
Mark, R.J.5
Blanc, E.M.6
Roth, G.S.7
Mattson, M.P.8
-
117
-
-
9844219728
-
Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice
-
(1997)
Hum Mol Genet
, vol.6
, pp. 1535-1541
-
-
Lamb, B.T.1
Call, L.M.2
Slunt, H.H.3
Bardel, K.A.4
Lawler, A.M.5
Eckman, C.B.6
Younkin, S.G.7
Holtz, G.8
Wagner, S.L.9
Price, D.L.10
Sisodia, S.S.11
Gearhart, J.D.12
-
118
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
Wals, P.11
Zhang, C.12
Finch, C.E.13
Krafft, G.A.14
Klein, W.L.15
-
119
-
-
0028804827
-
Structural model for the β amyloid fibril: Interstrand alignment of an antiparallel β sheet comprising a C-terminal peptide
-
(1995)
Nat Struct Biol
, vol.2
, pp. 990-998
-
-
Lansbury, P.T.1
Costa, P.R.2
Griffiths, J.M.3
Simon, E.J.4
Auger, M.5
Halverson, K.J.6
Kocisko, D.A.7
Hendsch, Z.C.8
Ashburn, T.T.9
Spencer, R.G.S.10
Tidor, B.11
Griffin, R.G.12
-
120
-
-
0031587956
-
2+]I in rat astrocytes
-
(1997)
Biochem Biophys Res Commun
, vol.235
, pp. 479-481
-
-
Laskay, G.1
Zarandi, M.2
Varga, J.3
Jost, K.4
Fonagy, A.5
Torday, C.6
Latzkovits, L.7
Penke, B.8
-
121
-
-
0029116848
-
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
-
(1995)
Nature
, vol.377
, pp. 351-354
-
-
Levitan, D.1
Greenward, I.2
-
122
-
-
0029906585
-
Assessment of normal and mutant presenilin function in Caenorhabditis elegans
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14940-14944
-
-
Levitan, D.1
Doyle, T.G.2
Brousseau, D.3
Lee, M.K.4
Thinakaran, G.5
Slunt, H.H.6
Sisodia, S.S.7
Greenward, I.8
-
123
-
-
0025296269
-
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
-
(1990)
Science
, vol.248
, pp. 1124-1126
-
-
Levy, E.1
Carman, M.D.2
Fernandez-Madrid, I.J.3
Power, M.D.4
Lieberburg, I.5
Van Duinen, B.T.6
Bots, A.M.7
Luyendijk, W.8
Frangione, B.9
-
124
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Waso, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
Pettingell, W.H.6
Yu, C.-H.7
Guenette, S.Y.8
Galas, D.9
Nemens, E.10
Wijsman, E.M.11
Bird, T.D.12
Schellenberg, G.D.13
Tanzi, R.E.14
-
131
-
-
0024503377
-
The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome
-
(1989)
J Neurol Sci
, vol.89
, pp. 169-179
-
-
Mann, D.M.A.1
Esiri, M.M.2
-
132
-
-
0030879207
-
A 12-month, randomized, placebo-controlled trial of propentofylline (HWA285) in patients with dementia according to DMSIII-R
-
(1997)
Dement Geriatr Cogn Disord
, vol.8
, pp. 320-328
-
-
Marcusson, J.1
Rother, M.2
Kittner, B.3
Rössner, M.4
Smith, R.J.5
Babic, T.6
Folnegovic-Smalc, V.7
Möller, H.J.8
Labs, K.H.9
-
135
-
-
0030779677
-
Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivatives
-
(1997)
Physiol Rev
, vol.77
, pp. 1081-1132
-
-
Mattson, M.P.1
-
142
-
-
0029610011
-
The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
-
(1995)
Brain Res Rev
, vol.21
, pp. 195-218
-
-
McGeer, P.L.1
McGeer, E.G.2
-
145
-
-
0028953529
-
Activation of microglial cells by β-amyloid protein and interferon-γ
-
(1995)
Nature
, vol.374
, pp. 647-659
-
-
Meda, L.1
Cassatella, M.A.2
Szendrei, G.I.3
Otvos L., Jr.4
Baron, P.5
Villalba, M.6
Ferrari, D.7
Rossi, F.8
-
147
-
-
0028914019
-
Interaction of anthracycline 4′-iodo-4′-deoxydoxorubicin with amyloid fibrils: Inhibition of amyloidogenesis
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 2959-2963
-
-
Merlini, G.1
Ascari, E.2
Amboldi, N.3
Bellotti, V.4
Arbustini, E.5
Perfetti, V.6
Ferrari, M.7
Zorzoli, I.8
Marinone, M.G.9
Garini, P.10
Diegoli, M.11
Trizio, D.12
Ballinari, D.13
-
152
-
-
0033528666
-
Differential effects of apolipoprotein E isoforms on metal-induced aggregation of Aβ using physiological concentrations
-
(1999)
Biochemistry
, vol.38
, pp. 4595-4603
-
-
Moir, R.D.1
Atwood, C.S.2
Romano, D.M.3
Laurans, M.H.4
Huang, X.5
Bush, A.I.6
Smith, J.D.7
Tanzi, R.E.8
-
159
-
-
0022639418
-
Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis
-
(1986)
Behav Neurosci
, vol.100
, pp. 23-32
-
-
Murray, C.L.1
Fibiger, H.C.2
-
161
-
-
0027358874
-
Behavioral aspects of cholinergic transmission: Role for basal forebrain cholinergic system in learning and memory
-
(1993)
Prog Brain Res
, vol.98
, pp. 405-411
-
-
Nabeshima, T.1
-
162
-
-
0027984961
-
Ameliorating effects of nefiracetam (DM-9384) on brain dysfunction
-
(1994)
Drugs Today
, vol.30
, pp. 357-379
-
-
Nabeshima, T.1
-
163
-
-
0000966780
-
Toxicity of β-amyloid protein: Neurochemical, histological and behavioral changes
-
K. Iqbal, B. Winblad, T. Nishimura, M. Takeda, & H. M. Wisniewski (Eds.), Alzheimer's Disease: Biology, Diagnosis and Therapeutics. Chichester: Wiley
-
(1997)
, pp. 623-630
-
-
Nabeshima, T.1
Itoh, A.2
-
166
-
-
0006626461
-
New therapeutic approaches to Alzheimer's disease
-
C. Tanaka, Y. Ihara, & P. L. McGeer (Eds.), Neuroscientific Basis of Dementia. Basel: Birkhauser Verlag
-
(1999)
, pp. 287-294
-
-
Nabeshima, T.1
Yamada, K.2
-
169
-
-
0032588722
-
Accumulation of murine amyloid β42 in a gene-dosage-dependent manner in PS1 'knock-in' mice
-
(1999)
Eur J Neurosci
, vol.11
, pp. 2577-2581
-
-
Nakano, Y.1
Kondoh, G.2
Kudo, T.3
Imaizumi, K.4
Kato, M.5
Miyazaki, J.6
Tohyama, M.7
Takeda, J.8
Takeda, M.9
-
170
-
-
0030978998
-
Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein
-
(1997)
Nature
, vol.387
, pp. 500-505
-
-
Nalbantoglu, J.1
Tirado-Santiago, G.2
Lahsaini, A.3
Porier, J.4
Goncalves, O.5
Verge, G.6
Momoli, F.7
Welner, S.A.8
Massicotte, G.9
Julien, J.P.10
Shapiro, M.L.11
-
172
-
-
0025754007
-
Missense mutation of Val→Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease
-
(1991)
Lancet
, vol.337
, pp. 978-979
-
-
Naruse, S.1
Igarashi, S.2
Kobayashi, H.3
Aoki, K.4
Inuzuka, T.5
Kaneko, K.6
Shimizu, T.7
Iihara, K.8
Kojima, T.9
Miyataka, T.10
Tsuji, S.11
-
179
-
-
0028343519
-
Oral administration of idebenone induces nerve growth factor in the brain and improves learning and memory in basal-forebrain-lesioned rats
-
(1994)
Naunyn Schmiedebergs Arch Pharmacol
, vol.349
, pp. 401-407
-
-
Nitta, A.1
Murase, K.2
Furukawa, Y.3
Kawatsura, W.4
Hayashi, K.5
Yamada, K.6
Hasegawa, T.7
Nabeshima, T.8
-
182
-
-
0022723508
-
One of the antigenic determinants of paired helical filaments is related to tau protein
-
(1986)
J Biochem
, vol.99
, pp. 1541-1544
-
-
Nukina, N.1
Ihara, Y.2
-
186
-
-
18544411933
-
Mutant presenilin 2 transgenic mouse: Effect on an age-dependent increase of amyloid β-protein 42 in the brain
-
(1998)
J Neurochem
, vol.71
, pp. 313-322
-
-
Oyama, F.1
Sawamura, N.2
Kobayashi, K.3
Morishima-Kawashima, M.4
Kuramochi, T.5
Ito, M.6
Tomita, T.7
Maruyama, K.8
Saido, T.C.9
Iwatsubo, T.10
Capell, A.11
Walter, J.12
Grünberg, J.13
Ueyama, Y.14
Haass, C.15
Ihara, Y.16
-
194
-
-
0028172930
-
Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease
-
(1994)
Trends Neurosci
, vol.17
, pp. 525-530
-
-
Poirier, J.1
-
195
-
-
0023870043
-
A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors
-
(1988)
Nature
, vol.331
, pp. 525-527
-
-
Ponte, P.1
Gonzalez-Dewhitt, P.2
Schelling, J.3
Miller, J.4
Hsu, D.5
Greenberg, B.6
Davis, K.7
Wallace, W.8
Lieberburg, I.9
Fuller, F.10
-
196
-
-
14444284106
-
Tau is a candidate gene for chromosome 17 frontotemporal dementia
-
(1998)
Ann Neurol
, vol.43
, pp. 815-825
-
-
Poorkaj, P.1
Bird, T.D.2
Wijsman, E.3
Nemens, E.4
Garruto, R.5
Anderson, L.6
Andreadis, A.7
Wiederholt, W.C.8
Raskind, M.9
Schellenberg, G.D.10
-
201
-
-
0029788661
-
Enhanced amyloidogenic processing of the β-amyloid precursor protein in gene targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Aβ sequence
-
(1996)
J Biol Chem
, vol.271
, pp. 23380-23388
-
-
Reaueme, A.G.1
Howland, D.S.2
Trusko, S.P.3
Savage, M.J.4
Lang, D.M.5
Greenberg, B.D.6
Siman, R.7
Scott, R.W.8
-
204
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
Chi, H.7
Lin, C.8
Holman, K.9
Tsuda, T.10
Mar, L.11
Sorbi, S.12
Nacmias, B.13
Piacentini, S.14
Amaducci, L.15
Chumakov, I.16
Cohen, D.17
Lannfelt, L.18
Fraser, P.E.19
Rommens, J.M.20
St George-Hyslop, P.H.21
more..
-
206
-
-
0030967165
-
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease
-
(1997)
N Engl J Med
, vol.336
, pp. 1216-1222
-
-
Sano, M.1
Ernesto, C.2
Thomas, R.G.3
Klauber, M.R.4
Schafer, K.5
Grundman, M.6
Woodbury, P.7
Growdon, J.8
Cotman, C.W.9
Pfeiffer, E.10
Schneider, L.S.11
Thal, L.J.12
-
208
-
-
0027327267
-
Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease
-
(1993)
Neurology
, vol.43
, pp. 1467-1472
-
-
Saunders, A.M.1
Strittmatter, W.J.2
Schmechel, D.3
George-Hyslop, P.H.4
Pericak-Vance, M.A.5
Joo, S.H.6
Rosi, B.L.7
Gusella, J.F.8
Crapper-MacLachlan, D.R.9
Albert, M.J.10
Hulette, C.11
Crain, B.12
Goldgaber, D.13
Roses, A.D.14
-
209
-
-
0033536163
-
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
Hu, K.7
Huang, J.8
Jonson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandervert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
210
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
211
-
-
0027365822
-
Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 9649-9653
-
-
Schmechel, D.E.1
Saunders, A.M.2
Strittmatter, W.J.3
Crain, B.J.4
Hulette, C.M.5
Joo, S.H.6
Pericak-Vance, M.A.7
Goldgaber, D.8
Roses, A.D.9
-
213
-
-
0032211830
-
The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
-
(1998)
Trends Cell Biol
, vol.8
, pp. 447-453
-
-
Selkoe, D.J.1
-
214
-
-
0033600274
-
Translating cell biology into therapeutic advances in Alzheimer's disease
-
(1999)
Nature
, vol.399
-
-
Selkoe, D.J.1
-
215
-
-
0026646605
-
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
-
(1992)
Nature
, vol.359
, pp. 325-327
-
-
Seubert, P.1
Vigo-Pelfrey, C.2
Esch, F.3
Lee, M.4
Dovey, H.5
Davis, D.6
Sinha, S.7
Schlossmacher, M.8
Whaley, J.9
Swindlehurst, C.10
McCormack, R.11
Wolfert, R.12
Selkoe, D.13
Lieberburg, I.14
Schenk, D.15
-
216
-
-
0027459686
-
Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide
-
(1993)
Nature
, vol.361
, pp. 260-263
-
-
Seubert, P.1
Oltersdorf, T.2
Lee, M.G.3
Barbour, R.4
Blomquist, C.5
Davis, D.L.6
Bryant, K.7
Fritz, L.C.8
Galasko, D.9
Thal, L.J.10
Lieberburg, I.11
Schenk, D.B.12
-
217
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, G.8
Holman, K.9
Tsuda, T.10
Mar, L.11
Foncin, J.-F.12
Bruni, A.C.13
Montesi, M.P.14
Sorbi, S.15
Rainero, I.16
Pinessi, L.17
Nee, L.18
Chumakov, I.19
Pollen, D.20
Brookes, A.21
Sanseau, P.22
Polinsky, R.J.23
Wasco, W.24
Da Silva, H.A.R.25
Haines, J.L.26
Pericak-Vance, M.A.27
Tanzi, R.E.28
Roses, A.D.29
Fraser, P.E.30
Rommens, J.M.31
St. George-Hyslop, P.H.32
more..
-
220
-
-
0033518251
-
Purification and cloning of amyloid precursor protein β-secretase from human brain
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
Doan, M.7
Dovey, H.F.8
Frigon, N.9
Hong, J.10
Jacobson-Croak, K.11
Jewett, N.12
Keim, P.13
Knops, J.14
Lieberburg, I.15
Power, M.16
Tan, H.17
Tatsuno, G.18
Tung, J.19
Schenk, D.20
Seubert, P.21
Suomensaari, S.M.22
Wang, S.23
Walker, D.24
Zhao, J.25
McConlogue, L.26
John, V.27
more..
-
224
-
-
0031981072
-
Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress
-
(1998)
J Neurochem
, vol.70
, pp. 2212-2215
-
-
Smith, M.A.1
Hirai, K.2
Hsiao, K.3
Pappolla, M.A.4
Harris, P.L.R.5
Siedlak, S.L.6
Tabaton, M.7
Perry, G.8
-
225
-
-
0028082136
-
An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar Aβ-amyloid in rat brain
-
(1994)
Neuron
, vol.12
, pp. 219-234
-
-
Snow, A.D.1
Sekiguchi, R.2
Nochlin, D.3
Fraser, P.4
Kimata, K.5
Mizutani, A.6
Arai, M.7
Schreier, W.A.8
Morgan, D.G.9
-
232
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
Wiederhold, K.-H.4
Mistl, C.5
Rothacher, S.6
Ledermann, B.7
Bürki, K.8
Frey, P.9
Paganetti, P.A.10
Waridel, C.11
Calhoun, M.12
Jucker, M.13
Probst, A.14
Staufenbiel, M.15
Sommer, B.16
-
233
-
-
0028322017
-
An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants
-
(1994)
Science
, vol.264
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.2
Cai, X.3
Odaka, A.4
Otvos, L.5
Eckman, C.6
Golde, T.7
Younkin, S.8
-
236
-
-
0031879794
-
NC-1900, an active fragment analog of arginine vasopressin, improves learning and memory deficits induced by β-amyloid protein in rats
-
(1998)
Eur J Pharmacol
, vol.352
, pp. 135-142
-
-
Tanaka, T.1
Yamada, K.2
Senzaki, K.3
Narimatsu, H.4
Nishimura, K.5
Kameyama, T.6
Nabeshima, T.7
-
237
-
-
0030591669
-
Effects of oestrogen during menopause on risk and age at onset of Alzheimer's disease
-
(1996)
Lancet
, vol.348
, pp. 429-432
-
-
Tang, M.-X.1
Jacobs, D.2
Stern, Y.3
Marder, K.4
Schofield, P.5
Gurland, B.6
Andrews, H.7
Mayeux, R.8
-
238
-
-
0023109592
-
The amyloid beta protein gene: cDNA cloning, mRNA distribution, and genetic linkage near the Alzheimer's locus
-
(1987)
Science
, vol.235
, pp. 880-884
-
-
Tanzi, R.E.1
Gusella, J.F.2
Watkins, P.C.3
Bruns, G.A.P.4
St George-Hyslop, P.H.5
VanKeuren, M.L.6
Patterson, D.7
Pagan, S.8
Kurnit, D.M.9
Neve, R.L.10
-
240
-
-
13344293701
-
Presence of soluble amyloid β-peptide precedes amyloid plaque formation in Down's syndrome
-
(1996)
Nat Med
, vol.2
, pp. 93-95
-
-
Teller, J.K.1
Russo, C.2
DeBusk, L.M.3
Angelini, G.4
Zaccheo, D.5
Dagna-Bricarelli, F.6
Scartezzini, P.7
Bertolini, S.8
Mann, D.M.A.9
Tabaton, M.10
Gambetti, P.11
-
242
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
Ratovitsky, T.7
Davenport, F.8
Nordstedt, C.9
Seeger, M.10
Hardy, J.11
Levey, A.I.12
Gandy, S.E.13
Jenkins, N.A.14
Copenland, N.G.15
Price, D.L.16
Sisodia, S.S.17
-
243
-
-
0029994633
-
Arrest of β-amyloid fibril formation by a pentapeptide ligand
-
(1996)
J Biol Chem
, vol.271
, pp. 8545-8548
-
-
Tjernberg, L.O.1
Näslund, J.2
Lindqvist, F.3
Johansson, J.4
Karlström, A.R.5
Thyberg, J.6
Terenius, L.7
Nordstedt, C.8
-
244
-
-
12644258498
-
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (43rd) residue
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2025-2030
-
-
Tomita, T.1
Maruyama, K.2
Saido, T.C.3
Kume, H.4
Shinozaki, K.5
Tokuhiro, S.6
Capell, A.7
Walter, J.8
Grünberg, J.9
Haass, C.10
Iwatsubo, T.11
Obata, K.12
-
247
-
-
0025369198
-
Amyloid β protein precursor gene and hereditary cerebral hemorrhage with amyloidosis
-
(1990)
Science
, vol.248
, pp. 1120-1122
-
-
Van Broeckhoven, C.1
Haan, J.2
Bakker, E.3
Hardy, J.A.4
Van Hul, W.5
Wehnert, A.6
Vegter-Van der Vlis, M.7
Roos, R.A.8
-
249
-
-
0033595706
-
β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.-C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
256
-
-
0024550204
-
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
-
(1989)
Cell
, vol.57
, pp. 115-126
-
-
Weidemann, A.1
König, G.2
Bunke, D.3
Fischer, P.4
Salbaum, J.5
Masters, C.6
Beyreuther, K.7
-
258
-
-
0032521111
-
Fibrillar β-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a selected population of neurons in rat CNS in vivo
-
(1998)
J Neurosci
, vol.18
, pp. 2161-2173
-
-
Weldon, D.1
Rogers, S.D.2
Ghilardi, J.R.3
Finke, M.P.4
Cleary, J.P.5
O'Hara, E.6
Esler, W.P.7
Maggio, J.E.8
Mantyh, P.W.9
-
259
-
-
0026725025
-
Neural lesioning with ribosome-inactivating proteins: Suicide transport and immunolesioning
-
(1992)
Trends Neurosci
, vol.15
, pp. 5986-5995
-
-
Wiley, R.G.1
-
270
-
-
0031081164
-
Orally active NGF synthesis stimulators: Potential therapeutic agents in Alzheimer's disease
-
(1997)
Behav Brain Res
, vol.83
, pp. 117-122
-
-
Yamada, K.1
Nitta, A.2
Hasegawa, T.3
Fuji, K.4
Hiramatsu, M.5
Kameyama, T.6
Furukawa, Y.7
Hayashi, K.8
Nabeshima, T.9
-
275
-
-
0032836539
-
Long-term deprivation of oestrogens by ovariectomy potentiates β-amyloid-induced working memory deficits in rats
-
(1999)
Br J Pharmacol
, vol.128
, pp. 419-427
-
-
Yamada, K.1
Tanaka, T.2
Zou, L.-B.3
Senzaki, K.4
Yano, K.5
Osada, T.6
Olariu, A.7
Ren, X.8
Kameyama, T.9
Nabeshima, T.10
-
276
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.4
Tory, M.C.5
Pauley, A.M.6
Brashler, J.R.7
Stratman, N.C.8
Mathews, W.R.9
Buhl, A.E.10
Carter, D.B.11
Tomasselli, A.G.12
Parodi, L.A.13
Heinrikson, R.L.14
Gurney, M.E.15
-
277
-
-
0013615899
-
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
-
(1996)
Nature
, vol.382
, pp. 685-691
-
-
Yan, S.D.1
Chen, X.2
Fu, J.3
Chen, M.4
Zhu, H.5
Roher, A.6
Slattery, T.7
Zhao, L.8
Nagashima, M.9
Morser, J.10
Migheli, A.11
Nawroth, P.12
Stern, D.13
Schmidt, A.M.14
-
278
-
-
0029896354
-
Mechanisms of neuronal degeneration in Alzheimer's disease
-
(1996)
Neuron
, vol.16
, pp. 921-932
-
-
Yankner, B.A.1
-
281
-
-
0028988801
-
β-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
-
(1995)
Cell
, vol.81
, pp. 525-531
-
-
Zheng, H.1
Jiang, M.2
Trumbauer, M.E.3
Sirinathsinghji, D.J.S.4
Hopkins, R.5
Smith, D.W.6
Heavens, R.P.7
Conner, M.W.8
Stevens, K.A.9
Slunt, H.H.10
Sisodia, S.S.11
Chen, H.Y.12
Van der Ploeg, L.H.T.13
|