Propentofylline prevents neuronal dysfunction induced by infusion of anti-nerve growth factor antibody into the rat septum

European Journal of Pharmacology

Volumn 307, Issue 1, 1996, Pages 1-6

  Nitta, Atsumi ^a,b   Ogihara, Yoshiko ^a   Onishi, Joji ^a   Hasegawa, Takaaki ^a   Furukawa, Shoei ^b   Nabeshima, Toshitaka ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Choline acetyltransferase; Dementia model; Learning; Memory; NGF (nerve growth factor); Propentofylline; Rat

Indexed keywords

CHOLINE ACETYLTRANSFERASE; CHOLINESTERASE; MONOCLONAL ANTIBODY; NERVE GROWTH FACTOR ANTIBODY; PROPENTOPHYLLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA; DRUG INFUSION; ENZYME ACTIVITY; INTRACEREBRAL DRUG ADMINISTRATION; LEARNING; MALE; MEMORY; NERVE CELL LESION; NONHUMAN; ORAL DRUG ADMINISTRATION; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; SEPTUM NUCLEUS; TASK PERFORMANCE;

EID: 0030594569     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00133-1     Document Type: Article

References (21)

1. Banati, R.B., J. Gehrmann, P. Schubert and G.W. Kreutzberg, 1993, Cytotoxicity of microglia, Glia 7, 111.
2. Bartus, R.T., R.L. Dean, B. Beer and A.S. Lippa, 1982, The cholinergic hypothesis of geriatric memory dysfunction, Science 217, 408.
3. Ellman, G.L., K.D. Courtney, V.A. Andres, Jr. and R.M. Featherstone, 1961, A new and rapid colorimetric determination of acetyl cholinesterase activity, Biochem. Pharmacol. 7, 88.
4. Friden, P.M., L.R. Walus, P. Watson, S.R. Doctrow, J.W. Kozarich, C. Backman, H. Bergman, B. Hoffer, F. Bloom and A.C. Granholm, 1993, Blood-brain barrier penetration and in vivo activity of an NGF conjugate, Science 259, 373.
5. Fuji, K. M. Hiramatsu, S. Hayashi, T. Kameyama and T. Nabeshima, 1993a, Effects of propentofylline, a NGF synthesis stimulator, on alterations in muscarinic cholinergic receptors induced by basal forebrain lesion in rats, Neurosci. Lett. 150, 99.
6. Fuji, K., M. Hiramatsu, T. Kameyama and T. Nabeshima, 1993b, Effects of repeated administration of propentofylline on memory impairment produced by basal forebrain lesion in rats, Eur. J. Pharmacol. 236, 411.
7. Hefti, F., A. Dravid and J. Hartikka, 1984, Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septohippocampal lesions, Brain Res. 293, 305.
8. Honegger, P. and D. Lenoir, 1982, Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures, Dev. Brain Res. 3, 229.
9. Kaneda, N. and T. Nagatsu, 1985, Highly sensitive assay for choline acetyltransferase activity by high-performance liquid chromatography with electrochemical detection, J. Chromatogr. 341, 23.
10. Morris, R.G.M., 1984, Development of water-maze procedure for studying spatial learning in the rat, J. Neurosci. Meth. 11, 47.
11. Mrsulja, B.B., D.V. Micic and B.M. Djuricic, 1983, Gerbil stroke model: an approach to the study of therapeutic aspects of postischemic brain edema. Adv. Biosci. 43, 45.
12. Nabeshima, T., A. Nitta and T. Hasegawa, 1993, Impairment of learning and memory and the accessory symptom in aged rats as senile dementia model (3): oral administration of propentofylline produces recovery of reduced NGF content in the brain of aged rats, Jpn. J. Psychopharmacol. 13, 89.
13. Nitta, A., K. Hayashi, T. Hasegawa and T. Nabeshima, 1993a, Development of plasticity of brain function with repeated trainings and passage of time after basal forebrain lesions in rats, J. Neural Transm. [G-Sect] 93, 37.
14. Nitta, A., K. Murase, Y. Furukawa, K. Hayashi, T. Hasegawa and T. Nabeshima, 1993b, Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats. Neuroscience 57, 495.
15. Nitta, A., K. Murase, Y. Furukawa, K. Hayashi, T. Hasegawa and T. Nabeshima, 1993c, Effects of oral administration of a stimulator for nerve growth factor synthesis in basal forebrain-lesioned rats, Eur. J. Pharmacol. 250, 23.
16. 11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (Case Report), J. Neural Transm. [P-D Sect] 4, 79.
17. Paxinos, G. and C. Watson, 1986, The Rat Brain in the Stereotaxic Coordinates (Academic Press, North Ryde).
18. Shinoda, I., Y. Furukawa and S. Furukawa, 1990, Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells, Biochem. Pharmacol. 49, 1813.
19. Sims, N.R., D. M, Bowen, S.J. Allen, C.C.T. Smith, D. Neary, D.J. Thomas and A.N. Davison, 1983, Presynaptic cholinergic dysfunction in patients with dementia, J. Neurochem. 40, 503.
20. Stefanovich, V. and K. Nagata, 1983, Effects of propentofylline and cinepazide on cerebral energy metabolism in nitrogen breathing rats, IRCS Med, Sci. 11,972.
21. Winkler, J., S.T. Suhr, F.H. Gage, L.J. Thal and L.J. Fisher, 1995, Essential role of neocortical acetylcholine in spatial memory, Nature 375, 484.