-
1
-
-
0028945660
-
Evidence that Aβ42 is the real culprit in Alzheimer's disease
-
Younkin SG. Evidence that Aβ42 is the real culprit in Alzheimer's disease. Ann Neurol 1995;37:287-288
-
(1995)
Ann Neurol
, vol.37
, pp. 287-288
-
-
Younkin, S.G.1
-
2
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
-
Borchelt DR, Thinakaran G, Eckman CB, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 1996;17:1005-1013
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
-
3
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
-
Citron M, Westaway D, Xia W, et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nat Med 1997;3:67-72
-
(1997)
Nat Med
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
-
4
-
-
12644258498
-
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
-
Tomita T, Maruyama K, Saido TC, et al. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc Natl Acad Sci USA 1997;94:2025-2030
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2025-2030
-
-
Tomita, T.1
Maruyama, K.2
Saido, T.C.3
-
5
-
-
16944365745
-
Enhanced production and oligomerization of the 42-residue amyloid β-protein by Chinese hamster ovary cells stably expressing mutant presenilins
-
Xia W, Zhang J, Kholodenko D, et al. Enhanced production and oligomerization of the 42-residue amyloid β-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem 1997;272:7977-7982
-
(1997)
J Biol Chem
, vol.272
, pp. 7977-7982
-
-
Xia, W.1
Zhang, J.2
Kholodenko, D.3
-
6
-
-
0029788661
-
Enhanced amyloidogenic processing of the β-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Aβ sequence
-
Reaume AG, Howland DS, Trusko SP, et al. Enhanced amyloidogenic processing of the β-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Aβ sequence. J Biol Chem 1996;271:23380-23388
-
(1996)
J Biol Chem
, vol.271
, pp. 23380-23388
-
-
Reaume, A.G.1
Howland, D.S.2
Trusko, S.P.3
-
7
-
-
0031020909
-
Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease
-
Johnson-Wood K, Lee M, Motter R, et al. Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease. Proc Natl Acad Sci USA 1997;94: 1550-1555
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 1550-1555
-
-
Johnson-Wood, K.1
Lee, M.2
Motter, R.3
-
8
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996;2:864-870
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
9
-
-
0024412495
-
Molecular biology of Alzheimer's disease
-
Müller Hill B, Beyreuther K. Molecular biology of Alzheimer's disease. Annu Rev Biochem 1989;58:287-307
-
(1989)
Annu Rev Biochem
, vol.58
, pp. 287-307
-
-
Müller Hill, B.1
Beyreuther, K.2
-
10
-
-
0027994773
-
Amyloid β protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease
-
Nakamura T, Shoji M, Harigaya Y, et al. Amyloid β protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease. Ann Neurol 1994;36:903-911
-
(1994)
Ann Neurol
, vol.36
, pp. 903-911
-
-
Nakamura, T.1
Shoji, M.2
Harigaya, Y.3
-
11
-
-
0028170719
-
Soluble amyloid beta-protein in the cerebrospinal fluid from patients with Alzheimer's disease, vascular dementia and controls
-
Pirttila T, Kim KS, Mehta PD, et al. Soluble amyloid beta-protein in the cerebrospinal fluid from patients with Alzheimer's disease, vascular dementia and controls. J Neurol Sci 1994;127:90-95
-
(1994)
J Neurol Sci
, vol.127
, pp. 90-95
-
-
Pirttila, T.1
Kim, K.S.2
Mehta, P.D.3
-
12
-
-
0028181396
-
Soluble amyloid β-protein is a marker of Alzheimer amyloid in brain but not in cerebrospinal fluid
-
Tabaton M, Grazia Nunzi M, Xue R, et al. Soluble amyloid β-protein is a marker of Alzheimer amyloid in brain but not in cerebrospinal fluid. Biochem Biophys Res Commun 1994;200: 1598-1603
-
(1994)
Biochem Biophys Res Commun
, vol.200
, pp. 1598-1603
-
-
Tabaton, M.1
Grazia Nunzi, M.2
Xue, R.3
-
13
-
-
0028861225
-
Concentrations of amyloid β protein in cerebrospinal fluid of patients with Alzheimer's disease
-
van Gool WA, Kuiper MA, Walstra GJM, et al. Concentrations of amyloid β protein in cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol 1995;37:277-279
-
(1995)
Ann Neurol
, vol.37
, pp. 277-279
-
-
Van Gool, W.A.1
Kuiper, M.A.2
Walstra, G.J.M.3
-
14
-
-
18844472315
-
Cerebrospinal fluid levels of amyloid β-protein in Alzheimer's disease: Inverse severity of dementia and effect of ApoE genotype
-
Nitsch RM, Rebeck WG, Deng M, et al. Cerebrospinal fluid levels of amyloid β-protein in Alzheimer's disease: inverse severity of dementia and effect of ApoE genotype. Ann Neurol 1995;37:512-518
-
(1995)
Ann Neurol
, vol.37
, pp. 512-518
-
-
Nitsch, R.M.1
Rebeck, W.G.2
Deng, M.3
-
15
-
-
0028971443
-
Amyloid β-peptide in cerebrospinal fluid in individuals with the Swedish Alzheimer amyloid precursor protein mutation
-
Lannfelt L, Basun H, Vigo-Pelfrey C, et al. Amyloid β-peptide in cerebrospinal fluid in individuals with the Swedish Alzheimer amyloid precursor protein mutation. Neurosci Lett 1995;199: 203-206
-
(1995)
Neurosci Lett
, vol.199
, pp. 203-206
-
-
Lannfelt, L.1
Basun, H.2
Vigo-Pelfrey, C.3
-
16
-
-
0030071249
-
Assessment of amyloid β protein in cerebrospinal fluid as an aid in the diagnosis of Alzheimer's disease
-
Southwick PC, Yamagata SK, Echols CL, et al. Assessment of amyloid β protein in cerebrospinal fluid as an aid in the diagnosis of Alzheimer's disease. J Neurochem 1996;66:259-266
-
(1996)
J Neurochem
, vol.66
, pp. 259-266
-
-
Southwick, P.C.1
Yamagata, S.K.2
Echols, C.L.3
-
17
-
-
0030587520
-
Amyloid β protein in plasma from patients with sporadic Alzheimer's disease
-
Tamaoka A, Fukushima T, Sawamura N, et al. Amyloid β protein in plasma from patients with sporadic Alzheimer's disease. J Neurol Sci 1996;151:65-68
-
(1996)
J Neurol Sci
, vol.151
, pp. 65-68
-
-
Tamaoka, A.1
Fukushima, T.2
Sawamura, N.3
-
18
-
-
0028982454
-
Reduction of β-amyloid peptide 42 in the cerebrospinal fluid of patients with Alzheimer's disease
-
Motter R, Vigo-Pelfrey C, Kholodenko D, et al. Reduction of β-amyloid peptide 42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol 1995;38:643-648
-
(1995)
Ann Neurol
, vol.38
, pp. 643-648
-
-
Motter, R.1
Vigo-Pelfrey, C.2
Kholodenko, D.3
-
19
-
-
0029661424
-
Analysis of heterogeneous βA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay
-
Ida N, Hartmann T, Pantel J, et al. Analysis of heterogeneous βA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J Biol Chem 1996;271:22908-22914
-
(1996)
J Biol Chem
, vol.271
, pp. 22908-22914
-
-
Ida, N.1
Hartmann, T.2
Pantel, J.3
-
20
-
-
0031149062
-
Amyloid beta protein 42(43) in cerebrospinal fluid of patients with Alzheimer's disease
-
Tamaoka A, Sawamura N, Fukushima T, et al. Amyloid beta protein 42(43) in cerebrospinal fluid of patients with Alzheimer's disease. J Neurol Sci 1997;148:41-45
-
(1997)
J Neurol Sci
, vol.148
, pp. 41-45
-
-
Tamaoka, A.1
Sawamura, N.2
Fukushima, T.3
-
21
-
-
14444269228
-
Longitudinal study of cerebrospinal fluid levels of tau, Aβ40, and Aβ42(43) in Alzheimer's disease: A study in Japan
-
Kanai M, Matsubara E, Isoe K, et al. Longitudinal study of cerebrospinal fluid levels of tau, Aβ40, and Aβ42(43) in Alzheimer's disease: a study in Japan. Ann Neurol 1998;44:17-26
-
(1998)
Ann Neurol
, vol.44
, pp. 17-26
-
-
Kanai, M.1
Matsubara, E.2
Isoe, K.3
-
22
-
-
15644363081
-
High cerebrospinal fluid tau and low amyloid β42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein e genotype
-
Galasko D, Chang L, Motter R, et al. High cerebrospinal fluid tau and low amyloid β42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype. Arch Neurol 1998;55:937-945
-
(1998)
Arch Neurol
, vol.55
, pp. 937-945
-
-
Galasko, D.1
Chang, L.2
Motter, R.3
-
23
-
-
23544476438
-
(1-42) as a biochemical marker for Alzheimer's disease: A community-based follow-up study
-
Abstract
-
(1-42) as a biochemical marker for Alzheimer's disease: a community-based follow-up study. Neurobiol Aging 1998;19:S161 (Abstract)
-
(1998)
Neurobiol Aging
, vol.19
-
-
Andreasen, N.1
Hesse, C.2
Davidsson, P.3
-
24
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services task force on Alzheimer's disease
-
McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services task force on Alzheimer's disease. Neurology 1984;34:939-944
-
(1984)
Neurology
, vol.34
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
-
25
-
-
0016823810
-
Mini mental state: A practical method for grading the cognitive state of patients for the clinician
-
Folstein MF, Folstein SE, McHugh PR. Mini mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198
-
(1975)
J Psychiatr Res
, vol.12
, pp. 189-198
-
-
Folstein, M.F.1
Folstein, S.E.2
McHugh, P.R.3
-
27
-
-
0019967975
-
The global deterioration scale for assessment of primary degenerative dementia
-
Reisberg B, Ferris SH, DeLeon MJ, Crook TJ. The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiatry 1982;139:1136-1139
-
(1982)
Am J Psychiatry
, vol.139
, pp. 1136-1139
-
-
Reisberg, B.1
Ferris, S.H.2
DeLeon, M.J.3
Crook, T.J.4
-
28
-
-
0031741753
-
Traumatic brain injury increases β-amyloid peptide I-42 in cerebrospinal fluid
-
Raby CA, Morganti-Kossmann MC, Kossmann T, et al. Traumatic brain injury increases β-amyloid peptide I-42 in cerebrospinal fluid. J Neurochem 1998;71:2505-2509
-
(1998)
J Neurochem
, vol.71
, pp. 2505-2509
-
-
Raby, C.A.1
Morganti-Kossmann, M.C.2
Kossmann, T.3
-
29
-
-
0030831053
-
Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease: A study with magnetic resonance imaging
-
Schroder J, Pantel J, Ida N, et al. Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease: a study with magnetic resonance imaging. Mol Psychiatry 1997;2:505-507
-
(1997)
Mol Psychiatry
, vol.2
, pp. 505-507
-
-
Schroder, J.1
Pantel, J.2
Ida, N.3
-
30
-
-
0031278270
-
Lack of apolipoprotein e dramatically reduces amyloid beta-peptide deposition
-
Bales KR, Verina T, Dodel RC, et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet 1997;17:263-264
-
(1997)
Nat Genet
, vol.17
, pp. 263-264
-
-
Bales, K.R.1
Verina, T.2
Dodel, R.C.3
-
31
-
-
0029664434
-
Aβ-peptide length and apolipoprotein e genotype in Alzheimer's disease
-
Gearing M, Mori H, Mirra SS. Aβ-peptide length and apolipoprotein E genotype in Alzheimer's disease. Ann Neurol 1996; 39:395-399
-
(1996)
Ann Neurol
, vol.39
, pp. 395-399
-
-
Gearing, M.1
Mori, H.2
Mirra, S.S.3
-
32
-
-
0030966774
-
Intracellular and secreted Alzheimer's beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons
-
Tienari PJ, Ida N, Ikonen E, et al. Intracellular and secreted Alzheimer's beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons. Proc Natl Acad Sci USA 1997;94:4125-4130
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4125-4130
-
-
Tienari, P.J.1
Ida, N.2
Ikonen, E.3
-
33
-
-
0030769091
-
Distinct sites of intracellular production for Alzheimer's disease a beta40/42 amyloid peptides
-
Hartmann T, Bieger SC, Bruhl B, et al. Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med 1997;3:1016-1020
-
(1997)
Nat Med
, vol.3
, pp. 1016-1020
-
-
Hartmann, T.1
Bieger, S.C.2
Bruhl, B.3
-
34
-
-
0030769092
-
Alzheimer's a beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
-
Cook DG, Forman MS, Sung JC, et al. Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nat Med 1997;3:1021-1023
-
(1997)
Nat Med
, vol.3
, pp. 1021-1023
-
-
Cook, D.G.1
Forman, M.S.2
Sung, J.C.3
-
35
-
-
0030952217
-
Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42
-
Wild Bode C, Yamazaki T, Capell A, et al. Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42. J Biol Chem 1997;272:16085-16088
-
(1997)
J Biol Chem
, vol.272
, pp. 16085-16088
-
-
Wild Bode, C.1
Yamazaki, T.2
Capell, A.3
-
36
-
-
0029982042
-
Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study
-
Tierney MC, Szalai JP, Snow WG, et al. Prediction of probable Alzheimer's disease in memory-impaired patients: a prospective longitudinal study. Neurology 1996;46:661-665
-
(1996)
Neurology
, vol.46
, pp. 661-665
-
-
Tierney, M.C.1
Szalai, J.P.2
Snow, W.G.3
-
37
-
-
0028598502
-
Interaction between genetic and environmental risk factors for Alzheimer's disease: A reanalysis of case-control studies. EURODEM Risk Factors Research Group
-
Van Duijn CM, Clayton DG, Chandra V, et al. Interaction between genetic and environmental risk factors for Alzheimer's disease: a reanalysis of case-control studies. EURODEM Risk Factors Research Group. Genet Epidemiol 1994;11:539-551
-
(1994)
Genet Epidemiol
, vol.11
, pp. 539-551
-
-
Van Duijn, C.M.1
Clayton, D.G.2
Chandra, V.3
-
38
-
-
0031422960
-
Risk factors for clinically diagnosed Alzheimer's disease: A case-control study of a Greek population
-
Tsolaki M, Fountoulakis K, Chantzi E, Kazis A. Risk factors for clinically diagnosed Alzheimer's disease: a case-control study of a Greek population. Int Psychogeriatr 1997;9:327-341
-
(1997)
Int Psychogeriatr
, vol.9
, pp. 327-341
-
-
Tsolaki, M.1
Fountoulakis, K.2
Chantzi, E.3
Kazis, A.4
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