Enhanced amyloidogenic processing of the β-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a 'humanized' Aβ sequence

Journal of Biological Chemistry

Volumn 271, Issue 38, 1996, Pages 23380-23388

  Reaume, Andrew G ^a   Howland, David S ^a   Trusko, Stephen P ^a   Savage, Mary J ^a   Lang, Diane M ^a   Greenberg, Barry D ^a   Siman, Robert ^a   Scott, Richard W ^a  

^a CEPHALON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENOTYPE; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; SEQUENCE ANALYSIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BASE SEQUENCE; BRAIN CHEMISTRY; CHIMERA; DISEASE MODELS, ANIMAL; ENDOPEPTIDASES; GENE TARGETING; GENOTYPE; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE FRAGMENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SWEDEN;

ANIMALIA;

EID: 0029788661     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.38.23380     Document Type: Article

References (71)

1. Selkoe, D. J. (1991) Neuron 6, 487-498
2. Goldgaber, D., Lerman, M. I., McBride, O. W., Saffiotti, U., and Gajdusek, D. C. (1987) Science 236, 877-880
3. Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., and Muller-Hill, B. (1987) Nature 325, 733-736
4. Ponte, P., Gonzales-DeWhitt, P. J., Schilling, J., Miller, J., Hsu, D., Greenberg, B., Davis, K. Wallace, W., Lieberburg, I., Fuller, F., and Cordell, B. (1988) Nature 331, 525-527
5. Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S., and Ito, H. (1988) Nature 331, 530-532
6. Konig, G., Monning, U., Czech, C., Prior, R., Banati, R., Schreiter-Gasser, U., Bauer, J., Masters, C. L., and Beyreuther, K. (1992) J. Biol. Chem. 267, 10804-10809
7. Glenner, G. C., and Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
8. Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., and Beyreuther, K. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4245-4249
9. Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., and Ward, P. J. (1990) Science 248, 1122-1124
10. Anderson, J. P., Esch, F. S., Keim, P. S., Sambamurti, K., Lieberburg, I., and Robakis, N. K. (1991) Neurosci. Lett. 128, 126-128
11. Seubert, P., Oltersdorf, T., Lee, M. G., Barbour, R., Blomquist, C., Davis, D. L., Bryant, K., Fritz, L. C., Galasko, D., Thal, L. J., Lieberburg, I., and Shenk, D. B. (1993) Nature 361, 260-263
12. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., and Selkoe, D. J. (1992) Nature 359, 322-325
13. Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schlossmacher, M., Whaley, J., Swindlehurst, C., McCormack, R., Wolfert, R., Selkoe, D., Lieberburg, I., and Schenk, D. (1992) Nature 359, 325-327
14. Rumble, B., Retallack, R., Hilbich, C., Simms, G., Multhaup, G., Martins, R., Hockey, A., Montgomery, P., Beyreuther, K., and Masters, C. L. (1989) N. Engl. J. Med. 320, 1446-1452
15. Wisniewski, K. E., Wisniewski, H. M., and Wen, G. Y. (1985) Ann. Neurol. 17, 278-282
16. Mann, D. M. A. (1988) Mech. Ageing Dev. 34, 99-136
17. Chartier-Harlin, M.-C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rossor, M., Roques, P., Hardy, J., and Mullan, M. (1991) Nature 353, 844-846
18. Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., Mant, R., Newton, P., Rooke, K., Roques, P., Talbot, C., Pericak-Vance, M., Roses, A., Williamson, R., Rossor, M., Owen, M., and Hardy, J. (1991) Nature 349, 704-706
19. Naruse, S., Igarashi, S., Kobayashi, H., Aoki, K., Inuzuki, I., Kaneko, K., Shimizu, T., Iihara, K., Kojima, T., Miyatake, T., and Tsuji, T. (1991) Lancet 337, 978-979
20. Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B., and Lannfelt, L. (1992) Nat. Genet. 1, 345-347
21. Citron, M., Oltersdorf, T., Haass, C., McConologue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., and Selkoe, D. J. (1992) Nature 360, 672-674
22. Cai, X.-D., Golde, T. E., and Younkin, S. G. (1993) Science 259, 514-516
23. Haass, C., Hung, A. Y., Selkoe, D. J., and Teplow, D. B. (1994) J. Biol. Chem. 269, 17741-17748
24. Suzuki, N., Cheung, T. T., Cai, X.-D., Odaka, A., L. Otvos, J., Eckman, C., Golde, T. E., and Younkin, S. G. (1994) Science 264, 1336-1340
25. Tamaoka, A., Odaka, A., Ishibashi, Y., Usami, M., Sahara, N., Suzuki, N., Nukina, N., Mizusawa, H., Shoji, S., Kanazawa, I., and Mori, H. (1994) J. Biol. Chem. 269, 32721-32724
26. Citron, M., Vigo-Pelfrey, C., Teplow, D. B., Miller, C., Schenk, D., Johnston, J., Winblad, B., Venizelos, N., Lannfelt, L., and Selkoe, D. J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 11993-11997
27. Quon, D., Wang, Y., Catalano, R., Scardina, J. M., Murakami, K., and Cordell, B. (1991) Nature 352, 239-241
28. Higgins, L. S., Catalano, R., Quon, D., and Cordell, B. (1994) Ann. NY Acad. Sci. 695, 224-227
29. Mucke, L., Masliah, E., Johnson, W. B., Ruppe, M. D., Alford, M., Rockenstein, E. M., Forss-Peter, S., Pietropaolo, M., Mallory, M., and Abraham, C. R. (1994) Brain Res. 666, 151-167
30. Howland, D. S., Savage, M. J., Huntress, F. A., Wallace, R. E., Schwartz, D. A., Loh, T., Melloni, R. H., Jr., DeGennaro, L. J., Greenberg, B. D., Siman, R., Swanson, M. E., and Scott, R. W. (1995) Neurobiol. Aging 16, 685-699
31. Hsiao, K. K., Borchelt, D. R., Olson, K., Johannsdottir, R., Kitt, C., Yunis, W., Xu, S., Eckman, C., Younkin, S., Price, D., Iadecola, C., Clark, H. B., and Carlson, G. (1995) Neuron 15, 1203-1218
32. Games, D., Adams, D., Alessandrini, R., Barbour, R., Berthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., Guido, T., Hagopian, S., Johnson-Wood, K., Khan, K., Lee, M., Liebowitz, P., Lieberburg, I., Little, S., Masliah, E., McConlogue, L., Montoya-Zavala, M., Mucke, L., Paganini, L., Penniman, E., Power, M., Schenk, D., Seubert, P., Snyder, B., Soriano, F., Tan, H., Vitale, J., Wadsworth, S., Wolozin, B., and Zhao, J. (1995) Nature 373, 523-527
33. Pearson, B. E., and Choi, T. K. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 10578-10582
34. Lamb, B. T., Sisodia, S. S., Lawler, A. M., Slunt, H. H., Kitt, C. A., Kearns, W. G., Pearson, P. L., Price, D. L., and Gearhart, J. D. (1993) Nat. Genet. 5, 22-30
35. Kammesheidt, A., Boyce, F. M., Spanoyannis, A. F., Cummings, B. J., Ortegon, M., Cotman, C., Vaught, J. L., and Neve, R. L. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 10857-10861
36. Araki, E., Yamada, T., Takemura, K., Yamaguchi, H., Sakimura, K., Goto, I., and Sakaki, Y. (1995) Amyloid: Int. J. Exp. Clin. Invest, 2, 100-106
37. LaFerla, F. M., Tinkle, B. T., Bieberich, C. J., Haudenschild, C. C., and Jay, G. (1995) Nat. Genet. 9, 21-30
38. Rockenstein, E. M., McConologue, L., Tan, H., Power, M., Masliah, E., and Mucke, L. (1995) J. Biol. Chem. 270, 28257-28267
39. Mattson, M. P., Cheng, B., Culwell, A. R., Esch, F. R., Lieberburg, I., and Rydel, R. E. (1993) Neuron 10, 243-254
40. Smith-Swintosky, V. L., Pettigrew, L. C., Craddock, S. D., Culwell, A. R., Rydel, R. E., and Mattson, M. P. (1994) J. Neurochem. 63, 781-784
41. Reaume, A. G., deSouza, P. A., Kulkarni, S., Langille, B. L., Zhu, D., Davies, T. C., Juneja, S. C., Kidder, G. M., and Rossant, J. (1995) Science 267, 1831-1833
42. Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., and Mulligan, R. C. (1991) Cell 65, 1153-1163
43. Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., and Roder, J. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 8424-8428
44. Wurst, W., and Joyner, A. L. (1993) in Gene Targeting (Joyner, A. L., ed) pp. 33-61, IRL Press at Oxford University Press, Oxford, England
45. Wood, S. A., Pascoe, W. S., Schmidt, C., Kemler, R., Evans, M. J., and Allen, N. D. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 4582-4585
46. Hogan, B., Constantini, F., and Lacy, E. (1986) Manipulating the Mouse Embryo: A Laboratory Manual, pp. 89-149, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
47. Sauer, B., and Henderson, N. (1990) New Biol. 2, 441-449
48. Kim, K. S., Wen, G. Y., Bancher, C., Chen, C. J. M., Sapienza, V. J., Hong, H., and Wisniewski, H. M. (1990) Neurosci. Res. Commun. 7, 113-122
49. Savage, M. J., Iqbal, M., Loh, T., Trusko, S. P., Scott, R., and Siman, R. (1994) Neuroscience 60, 607-619
50. Siman, R., Durkin, J. T., Husten, E. J., Savage, M. J., Murthy, S., Mistretta, S., Chatterjee, S., Rotella, D., Dembofsky, B., Poorman, R., and Greenberg, B. D. (1995) in Research Advances in Alzheimer's Disease and Related Disorders (Iqbal, K., Mortimer, J. A., Winblad, B., and Wisniewski, H. M., eds) pp. 675-684, J. Wiley and Sons Ltd., Chichester, England
51. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
52. Laemmli, U. K. (1970) Nature 227, 680-685
53. Schagger, H., and von Jagow, G. (1987) Anal. Biochem. 166, 368-379
54. Yamada, T., Sasaki, H., Furuya, H., Miyata, T., Goto, I., and Sakaki, Y. (1987) Biochem. Biophys. Res. Commun. 149, 665-671
55. Yoshikai, S., Sasaki, H., Doh-ura, K., Furuya, H., and Sakaki, Y. (1990) Gene (Amst.) 87, 257-263
56. Capecchi, M. R. (1989) Science 244, 1288-1292
57. Mansour, S. L., Thomas, K. R., and Capecchi, M. R. (1988) Nature 336, 348-352
58. Suzuki, T., Oishi, M., Marshak, D. R., Czernik, A. J., Nairn, A. C., and Greengard, P. (1994) EMBO J. 13, 1114-1122
59. DeStrooper, B., Simons, M., Multhaup, G., Leuven, F. V., Beyreuther, K., and Dotti, C. G. (1995) EMBO J. 14, 4932-4938
60. DeStrooper, B., Umans, L., Leuven, F. V., and Berghe, H. V. D. (1993) J. Cell Biol. 121, 295-304
61. Sisodia, S. S. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 6075-6079
62. Busciglio, J., Gabuzda, D. H., Matsudaira, P., and Yankner, B. A. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 2092-2096
63. De Strooper, B., Craessaerts, K., Dewachter, I., Moechars, D., Greenberg, B., Van Leuven, F., and Van Den Berghe, H. (1995) J. Biol. Chem. 270, 4058-4065
64. Buxbaum, J. D., Koo, E. H., and Greengard, P. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 9195-9198
65. Hung, A. Y., Haass, C., Nitsch, R. M., Qiu, W. Q., Citron, M., Wurtman, R. J., Growdon, J. H., and Selkoe, D. J. (1993) J. Biol. Chem. 268, 22959-22962
66. Thinakaran, G., Teplow, D. B., Siman, R., Greenberg, B., and Sisodia, S. S. (1996) J. Biol. Chem. 271, 9390-9397
67. Dyrks, T., Monning, U., Beyreuther, K., and Turner, J. (1994) FEBS Lett. 349, 210-214
68. Fuller, S. J., Storey, E., Li, Q.-X., Smith, A. I., Beyreuther, K., and Masters, C. L. (1995) Biochemistry 34, 8091-8098
69. Otvos, L., Jr., Szendrei, G., Lee, V. M.-Y., and Mantsch, H. H. (1993) Eur. J. Biochem. 211, 249-257
70. Bush, A. I., Pettingell, W. H., Multhaup, G., Paradis, M. D., Vonsatell, J.-P., Gusella, J. F., Beyreuther, K., Masters, C. L., and Tanzi, R. E. (1994) Science 265, 1464-1467
71. Dyrks, T., Dyrks, E., Masters, C. L., and Beyreuther, K. (1993) FEBS Lett. 324, 231-236