The Alzheimer diseases

Current Opinion in Neurobiology

Volumn 6, Issue 5, 1996, Pages 644-650

  Roses, Allen D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID P COMPONENT; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E4; GENE PRODUCT;

ALZHEIMER DISEASE; GENE MUTATION; HUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0030273012     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(96)80098-5     Document Type: Article

References (48)

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2. of special interest Roses AD. Apolipoprotein E alleles as risk factors in Alzheimer disease. Annu Rev Med. 47:1996;387-400 A review of the clinical genetics of Alzheimer's disease.
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27. of outstanding interest Roses AD. Perspective: on the metabolism of apolipoprotein E and the Alzheimer diseases. Exp Neurol. 132:1995;149-156 This review summarizes the neurobiology of apoE.
28. Roses AD. Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. J Neuropathol Exp Neurol. 53:1994;429-437.
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39. Huang DY, Goedert M, Jakes R, Weisgraber K, Garner C, Saunders AM, Pericak-Vance MA, Schmechel D, Roses AD, Strittmatter WJ. Isoform-specific interactions of apolipoprotein E with the microtubule associated protein MAP2c: implications for Alzheimer's disease. Neurosci Lett. 182:1994;55-58.
40. of outstanding interest Huang DY, Weisgraber KH, Goedert M, Saunders AM, Roses AD, Strittmatter WJ. ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neurosci Lett. 192:1995;209-212 Demonstrates the importance of apoE3 binding to the state of phosphorylation of Ser262 in the first microtubule-associated protein binding domain of tau.
41. of special interest Holtzman DM, Pitas RE, Kilbridge J, Nathan B, Mahley RW, Bu GJ, Schwartz AL. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc Natl Acad Sci USA. 92:1995;9480-9484 Reports on apoE isoform-specific effects on neurite outgrowth in tissue culture.
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44. of outstanding interest Masliah E, Mallory M, Ge N, Alford M, Veinbergs I, Roses AD. Neurodegeneration in the central nervous system of apoE-deficient mice. Exp Neurol. 136:1995;107-122 Documents the age-dependent loss of synaptic density, revealed by MAP2 and synaptophysin immunohistology, in apoE-deficient mice.
45. Strittmatter WJ, Weisgraber KH, Goedert M, Saunders AM, Huang D, Corder EH, Dong LM, Jakes R, Alberts MJ, Gilbert JR, et al. Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp Neurol. 125:1994;163-171.
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48. of special interest Benzing WC, Mufson EJ. Apolipoprotein E immunoreactivity within neurofibrillary tangles: relationship to tau and PHF in Alzheimer's disease. Exp Neurol. 132:1995;162-171 Confirms the presence of intraneuronal apoE in controls and Alzheimer's disease patients, a finding that was initially controversial.