메뉴 건너뛰기




Volumn 706, Issue 2, 1996, Pages 181-193

Amnesia induced in mice by centrally administered β-amyloid peptides involves cholinergic dysfunction

Author keywords

Alternation behavior; Alzheimer's disease; Amnesia model; Neurotoxicity; Passive avoidance; Water maze; Amyloid peptide

Indexed keywords

AMYLOID BETA PROTEIN; NICOTINE; NICOTINIC AGENT; TACRINE;

EID: 0030048606     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(95)01032-7     Document Type: Article
Times cited : (505)

References (64)
  • 1
    • 0028179063 scopus 로고
    • Administration of amyloid β-petides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo
    • Abe, E., Casamenti, F., Giovannelli, L., Scali, C. and Pepeu, G., Administration of amyloid β-petides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo, Brain Res., 636 (1994) 162-164.
    • (1994) Brain Res. , vol.636 , pp. 162-164
    • Abe, E.1    Casamenti, F.2    Giovannelli, L.3    Scali, C.4    Pepeu, G.5
  • 2
    • 0027747873 scopus 로고
    • Long-term treatment with tacrine (THA) in Alzheimer's disease: Evaluation of neuropsychological data
    • Amberla, K., Nordberg, A., Viitanen, M. and Winblad, B., Long-term treatment with tacrine (THA) in Alzheimer's disease: evaluation of neuropsychological data, Acta Neurol. Scand. Suppl., 149 (1993) 55-57.
    • (1993) Acta Neurol. Scand. Suppl. , vol.149 , pp. 55-57
    • Amberla, K.1    Nordberg, A.2    Viitanen, M.3    Winblad, B.4
  • 3
    • 0027508926 scopus 로고
    • Alzheimer disease amyloid β protein forms calcium channels in bilayer membranes: Blockade by tromethamine and aluminium
    • Arispe, N., Rojas, E. and Pollard, B., Alzheimer disease amyloid β protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminium, Proc. Natl. Acad. Sci. USA, 90 (1993) 567-571.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 567-571
    • Arispe, N.1    Rojas, E.2    Pollard, B.3
  • 4
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfuncytion
    • Bartus, R.T., Dean, I.L., Beer, B. and Lippa, A., The cholinergic hypothesis of geriatric memory dysfuncytion, Science, 217 (1982) 408-417.
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.T.1    Dean, I.L.2    Beer, B.3    Lippa, A.4
  • 5
    • 0025960491 scopus 로고
    • Microtubule disruption and cognitive defects: Effect of colchicine on learning behaviour in rats
    • Bensimon, G. and Chermat, R., Microtubule disruption and cognitive defects: effect of colchicine on learning behaviour in rats, Pharmacol. Biochem. Behav., 38 (1991) 141-146.
    • (1991) Pharmacol. Biochem. Behav. , vol.38 , pp. 141-146
    • Bensimon, G.1    Chermat, R.2
  • 6
    • 0026699777 scopus 로고
    • Implants containing beta-amyloid protein are not neurotoxic to young and old rat brain
    • Clemens, J.A. and Stephenson, D.T., Implants containing beta-amyloid protein are not neurotoxic to young and old rat brain, Neurobiol. Aging, 13 (1992) 581-586.
    • (1992) Neurobiol. Aging , vol.13 , pp. 581-586
    • Clemens, J.A.1    Stephenson, D.T.2
  • 7
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • Coyle, J.T., Price, D.L. and DeLong, M.R., Alzheimer's disease: a disorder of cortical cholinergic innervation, Science, 219 (1983) 1184-1190.
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    DeLong, M.R.3
  • 8
    • 0023737806 scopus 로고
    • A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: Prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques
    • Davies, L., Wolska, B., Hilbich, C., Multhaup, G., Martins, R., Simms, G., Beyreuther, K. and Masters, C.L., A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques, Neurology, 38 (1988) 1688-1693.
    • (1988) Neurology , vol.38 , pp. 1688-1693
    • Davies, L.1    Wolska, B.2    Hilbich, C.3    Multhaup, G.4    Martins, R.5    Simms, G.6    Beyreuther, K.7    Masters, C.L.8
  • 9
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies, P. and Maloney, A.J.F., Selective loss of central cholinergic neurons in Alzheimer's disease, Lancet, 2 (1976) 1403.
    • (1976) Lancet , vol.2 , pp. 1403
    • Davies, P.1    Maloney, A.J.F.2
  • 10
    • 0027332990 scopus 로고
    • Bilateral injections of beta A(25-35) + IBO into the hippocampus disrupts acquisition of spatial learning in the rat
    • Dornan, W.A., Kang, D.E., McCampbell, A. and Kang, E.E., Bilateral injections of beta A(25-35) + IBO into the hippocampus disrupts acquisition of spatial learning in the rat, Neuroreport, 5 (1993) 165-168.
    • (1993) Neuroreport , vol.5 , pp. 165-168
    • Dornan, W.A.1    Kang, D.E.2    McCampbell, A.3    Kang, E.E.4
  • 11
    • 0025367968 scopus 로고
    • Intraventricular infusions of antibodies to amyloid beta-protein precursor impair the acquisition of a passive avoidance response in the rat
    • Doyle, E., Bruce, M.T., Breen, K.C., Smith, D.C., Anderton, B. and Reagan, C.M, Intraventricular infusions of antibodies to amyloid beta-protein precursor impair the acquisition of a passive avoidance response in the rat, Neurosci. Lett., 115 (1990) 97-102.
    • (1990) Neurosci. Lett. , vol.115 , pp. 97-102
    • Doyle, E.1    Bruce, M.T.2    Breen, K.C.3    Smith, D.C.4    Anderton, B.5    Reagan, C.M.6
  • 12
    • 0015965912 scopus 로고
    • Human memory and the cholinergic system: A relationship to aging?
    • Drachman, D.A. and Leavitt, J., Human memory and the cholinergic system: a relationship to aging?, Arch. Neurol., 30 (1974) 113-121.
    • (1974) Arch. Neurol. , vol.30 , pp. 113-121
    • Drachman, D.A.1    Leavitt, J.2
  • 13
    • 0026702704 scopus 로고
    • The acute neurotoxicity and effects upon cholinergic axons or intracerebrally injected beta-amyloid in the rat brain
    • Erme, M., Geula, C., Ransil, B.J. and Mesulam, M.M., The acute neurotoxicity and effects upon cholinergic axons or intracerebrally injected beta-amyloid in the rat brain, Neurobiol. Aging, 13 (1992) 553-559.
    • (1992) Neurobiol. Aging , vol.13 , pp. 553-559
    • Erme, M.1    Geula, C.2    Ransil, B.J.3    Mesulam, M.M.4
  • 16
    • 0026353502 scopus 로고
    • Amnestic effects in mice of four synthetic peptides homologous to amyloid β protein from patients with Alzheimer disease
    • Flood, J.F., Morley, J.E. and Roberts, E., Amnestic effects in mice of four synthetic peptides homologous to amyloid β protein from patients with Alzheimer disease, Proc. Natl. Acad. Sci. USA, 88(1991) 3363-3366.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3363-3366
    • Flood, J.F.1    Morley, J.E.2    Roberts, E.3
  • 17
    • 0028013301 scopus 로고
    • Topography of a binding site for small amnestic peptides deduced from structure-activity studies: Relation to amnestic effect of amyloid β protein
    • Flood, J.F., Roberts, E., Sherman, M.A., Kaplan, B.E. and Morley, J.E., Topography of a binding site for small amnestic peptides deduced from structure-activity studies: relation to amnestic effect of amyloid β protein, Proc. Natl. Acad. Sci. USA, 91 (1994) 380-384.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 380-384
    • Flood, J.F.1    Roberts, E.2    Sherman, M.A.3    Kaplan, B.E.4    Morley, J.E.5
  • 18
    • 0026070054 scopus 로고
    • Effects of injected Alzheimer β-amyloid cores in rat brain
    • Frautschy, S.A., Baird, A. and Cole, G.M., Effects of injected Alzheimer β-amyloid cores in rat brain, Proc. Natl. Acad. Sci. USA, 88 (1991) 8362-8366.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8362-8366
    • Frautschy, S.A.1    Baird, A.2    Cole, G.M.3
  • 21
    • 70449139880 scopus 로고
    • Pharmacological effects produced by intracerebral injections of drugs in the concious mouse
    • Haley, T.J. and McCormick, W.J., Pharmacological effects produced by intracerebral injections of drugs in the concious mouse, Br. J. Pharmacol., 12 (1957) 12-15.
    • (1957) Br. J. Pharmacol. , vol.12 , pp. 12-15
    • Haley, T.J.1    McCormick, W.J.2
  • 22
    • 0025275241 scopus 로고
    • Molecular deteminants of amyloid deposition in Alzheimer's disease: Conformational studies of synthetic β-protein fragments
    • Halverson, K., Frazier, P.E., Kirschner, D.A. and Lansbury, Jr., P.T., Molecular deteminants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic β-protein fragments, Biochemistry, 29 (1990) 2639-2644.
    • (1990) Biochemistry , vol.29 , pp. 2639-2644
    • Halverson, K.1    Frazier, P.E.2    Kirschner, D.A.3    Lansbury P.T., Jr.4
  • 23
    • 0026770881 scopus 로고
    • Involvement of the cholinergic system in the effect of nefiracetam (DM-9384) on carbon monoxide (CO)-induced acute and delayed amnesia
    • Hiramatsu, M., Koide, T., Ishihara, S., Shiotani, T., Kameyama, T. and Nabeshima, T., Involvement of the cholinergic system in the effect of nefiracetam (DM-9384) on carbon monoxide (CO)-induced acute and delayed amnesia, Eur. J. Pharmacol., 216 (1992) 279-285.
    • (1992) Eur. J. Pharmacol. , vol.216 , pp. 279-285
    • Hiramatsu, M.1    Koide, T.2    Ishihara, S.3    Shiotani, T.4    Kameyama, T.5    Nabeshima, T.6
  • 24
    • 0025228457 scopus 로고
    • Utility of an elevated plus-maze for the evaluation of memory in mice: Effects of nootropic, scopolamine and electroconvulsive shock
    • Itoh, J., Nabeshima, T. and Kameyama, T., Utility of an elevated plus-maze for the evaluation of memory in mice: effects of nootropic, scopolamine and electroconvulsive shock, Psychopharmacology, 101 (1990) 27-33.
    • (1990) Psychopharmacology , vol.101 , pp. 27-33
    • Itoh, J.1    Nabeshima, T.2    Kameyama, T.3
  • 25
    • 0028270519 scopus 로고
    • A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The tacrine study group
    • Knapp, M.J., Knopman, D.S., Solomon, P.R., Pendelbury, W.W., Davis, C.S. and Gracon, S.I., A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The tacrine study group, J. Am. Med. Assoc., (1994) 271 985-991.
    • (1994) J. Am. Med. Assoc. , pp. 271985-271991
    • Knapp, M.J.1    Knopman, D.S.2    Solomon, P.R.3    Pendelbury, W.W.4    Davis, C.S.5    Gracon, S.I.6
  • 26
    • 0025879957 scopus 로고
    • An in vivo model for the neurodegenerative effects of β-amyloid and protection by substance P
    • Kowall, N.W., Beal, M.F., Busciglio, J., Duffy, L.K. and Yanker, B.A., An in vivo model for the neurodegenerative effects of β-amyloid and protection by substance P, Proc. Natl. Acad. Sci. USA, 88 (1991) 7247-7251.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7247-7251
    • Kowall, N.W.1    Beal, M.F.2    Busciglio, J.3    Duffy, L.K.4    Yanker, B.A.5
  • 27
    • 0026646328 scopus 로고
    • In vivo neurotoxicity of β-amyloid β(1-40) and the β(25-35) fragment
    • Kowall, N.W., McKee, A.C., Yankner, B.A. and Beal, M.F., In vivo neurotoxicity of β-amyloid β(1-40) and the β(25-35) fragment, Neurobiol. Aging, 13 (1992) 537-542.
    • (1992) Neurobiol. Aging , vol.13 , pp. 537-542
    • Kowall, N.W.1    McKee, A.C.2    Yankner, B.A.3    Beal, M.F.4
  • 30
    • 0028175439 scopus 로고
    • Efficacy of tacrine and lecithin in mild to moderate Alzheimer's disease: Double blind trial
    • Maltby, N., Broe, G.A., Creasey, H., Jorm, A.F., Christensen, H. and Brooks, W.S., Efficacy of tacrine and lecithin in mild to moderate Alzheimer's disease: double blind trial, Br. Med. J., 308 (1994) 879-883.
    • (1994) Br. Med. J. , vol.308 , pp. 879-883
    • Maltby, N.1    Broe, G.A.2    Creasey, H.3    Jorm, A.F.4    Christensen, H.5    Brooks, W.S.6
  • 33
    • 0028962011 scopus 로고
    • Learning impairment following acute administration of the calcium channel antagonist nimodipine in mice
    • Maurice, T., Bayle, J. and Privat, A., Learning impairment following acute administration of the calcium channel antagonist nimodipine in mice, Behav. Pharmacol., 6 (1995) 167-175.
    • (1995) Behav. Pharmacol. , vol.6 , pp. 167-175
    • Maurice, T.1    Bayle, J.2    Privat, A.3
  • 34
    • 0028242679 scopus 로고
    • Cholecystokinin-related peptides, after systemic or central administration, prevent carbon monoxide-induced amnesia in mice
    • Maurice, T., Hiramatsu, M., Kameyama, T., Hasegawa, T. and Nabeshima, T., Cholecystokinin-related peptides, after systemic or central administration, prevent carbon monoxide-induced amnesia in mice, J. Pharmacol. Exp. Ther., 269 (1994) 665-673.
    • (1994) J. Pharmacol. Exp. Ther. , vol.269 , pp. 665-673
    • Maurice, T.1    Hiramatsu, M.2    Kameyama, T.3    Hasegawa, T.4    Nabeshima, T.5
  • 35
    • 0028178742 scopus 로고
    • Effects of an exogenous beta-amyloid peptide on retention for spatial learning
    • McDonald, M.P., Dahl, E.E., Overmier, J.B., Mantyh, P. and Cleary, J., Effects of an exogenous beta-amyloid peptide on retention for spatial learning, Behav. Neur. Biol., 62 (1994) 60-67.
    • (1994) Behav. Neur. Biol. , vol.62 , pp. 60-67
    • McDonald, M.P.1    Dahl, E.E.2    Overmier, J.B.3    Mantyh, P.4    Cleary, J.5
  • 36
    • 0026393430 scopus 로고
    • Senile dementia: A threshold phenomenon of normal aging? A contribution of the functional reserve hypothesis of the brain
    • Meier-Ruge, W., Hunziker, O. and Iwangoff, P., Senile dementia: a threshold phenomenon of normal aging? A contribution of the functional reserve hypothesis of the brain, Ann. New York Acad. Sci., 621 (1991) 104-118.
    • (1991) Ann. New York Acad. Sci. , vol.621 , pp. 104-118
    • Meier-Ruge, W.1    Hunziker, O.2    Iwangoff, P.3
  • 37
    • 0022619816 scopus 로고
    • The cytoskeleton and neurofibrillary tangles in A.D.
    • Miller, C., Haugh, M., Kahn, J. and Anderton, B., The cytoskeleton and neurofibrillary tangles in A.D., Trends Neurosci., 9 (1986) 76-81.
    • (1986) Trends Neurosci. , vol.9 , pp. 76-81
    • Miller, C.1    Haugh, M.2    Kahn, J.3    Anderton, B.4
  • 38
    • 0028177692 scopus 로고
    • β-Amyloid protein-induced Alzheimer's disease animal model
    • Nitta, A., Itoh, A., Hasegawa, T. and Nabeshima, T., β-Amyloid protein-induced Alzheimer's disease animal model, Neurosci. Lett., 170 (1994) 63-66.
    • (1994) Neurosci. Lett. , vol.170 , pp. 63-66
    • Nitta, A.1    Itoh, A.2    Hasegawa, T.3    Nabeshima, T.4
  • 40
    • 0018078940 scopus 로고
    • Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia
    • Perry, E.K., Tomlinson, B.E., Blessed, G., Bergman, K., Gibson, P.H. and Perry, R.H., Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia, Br. Med. J., 2 (1978) 1457-1459.
    • (1978) Br. Med. J. , vol.2 , pp. 1457-1459
    • Perry, E.K.1    Tomlinson, B.E.2    Blessed, G.3    Bergman, K.4    Gibson, P.H.5    Perry, R.H.6
  • 41
    • 0027447286 scopus 로고
    • Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
    • Pike, C.J., Burdick, D., Walencewicz, A.J., Glabe, C.G. and Cotman, C.W., Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state, J. Neurosci., 13 (1993) 1676-1687.
    • (1993) J. Neurosci. , vol.13 , pp. 1676-1687
    • Pike, C.J.1    Burdick, D.2    Walencewicz, A.J.3    Glabe, C.G.4    Cotman, C.W.5
  • 42
    • 0025992417 scopus 로고
    • In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity
    • Pike, C.J., Walencewicz, A.J., Glabe, C.G. and Cotman, C.W., In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity, Brain Res., 563 (1991) 311-314.
    • (1991) Brain Res. , vol.563 , pp. 311-314
    • Pike, C.J.1    Walencewicz, A.J.2    Glabe, C.G.3    Cotman, C.W.4
  • 45
    • 84913057245 scopus 로고    scopus 로고
    • No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type
    • in press
    • Regeur, L., Badsberg Jensen, G., Pakkenberg, H., Evans, S.M. and Pakkenberg, B., No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type, Neurobiol. Aging, in press.
    • Neurobiol. Aging
    • Regeur, L.1    Badsberg Jensen, G.2    Pakkenberg, H.3    Evans, S.M.4    Pakkenberg, B.5
  • 46
    • 0026644548 scopus 로고
    • Intracerebral beta-amyloid(25-35) produces tissue damage: Is it neurotoxic?
    • Rush, D.K., Aschimes, S. and Merriman, M.C., Intracerebral beta-amyloid(25-35) produces tissue damage: is it neurotoxic?, Neurobiol. Aging, 13 (1992) 591-594.
    • (1992) Neurobiol. Aging , vol.13 , pp. 591-594
    • Rush, D.K.1    Aschimes, S.2    Merriman, M.C.3
  • 47
    • 0027735697 scopus 로고
    • Tetrahydroaminoacridine (THA) in Alzheimer's disease: An assessment of attentional and mnemonic function using CANTAB
    • Sahakian, B.J. and Coull, J.T., Tetrahydroaminoacridine (THA) in Alzheimer's disease: an assessment of attentional and mnemonic function using CANTAB, Acta Neurol. Scand. Suppl., 149 (1993) 29-35.
    • (1993) Acta Neurol. Scand. Suppl. , vol.149 , pp. 29-35
    • Sahakian, B.J.1    Coull, J.T.2
  • 48
    • 0028064941 scopus 로고
    • Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH): Two amino acids length difference to human and murine homologues
    • Sandbrink, R., Masters, C.L. and Beyreuther, K., Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH): two amino acids length difference to human and murine homologues, Biochim. Biophys. Acta, 1219 (1994) 167-170.
    • (1994) Biochim. Biophys. Acta , vol.1219 , pp. 167-170
    • Sandbrink, R.1    Masters, C.L.2    Beyreuther, K.3
  • 49
    • 0023832413 scopus 로고
    • Attenuation of the scopolamine-induced impairment of spontaneous alternation behaviour by antagonist but not inverse agonist and agonist β-carbolines
    • Sarter, M., Bodewitz, G. and Stephens, D., Attenuation of the scopolamine-induced impairment of spontaneous alternation behaviour by antagonist but not inverse agonist and agonist β-carbolines, Psychopharmacology, 94 (1988) 491-495.
    • (1988) Psychopharmacology , vol.94 , pp. 491-495
    • Sarter, M.1    Bodewitz, G.2    Stephens, D.3
  • 50
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe, D.J., The molecular pathology of Alzheimer's disease, Neuron, 6 (1991) 487-498.
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 51
    • 0024005801 scopus 로고
    • Alzheimer's disease amyloidogenic glycoprotein: Expression pattern in rat brain suggests a role in cell contact
    • Shivers, B.D., Hilbich, C., Multhaup, G., Salbaum, M., Beyreuther, K. and Seeburg, P.H., Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact, EMBO J., (1988) 7, 1365-1370.
    • (1988) EMBO J. , vol.7 , pp. 1365-1370
    • Shivers, B.D.1    Hilbich, C.2    Multhaup, G.3    Salbaum, M.4    Beyreuther, K.5    Seeburg, P.H.6
  • 53
    • 0027166738 scopus 로고
    • Amyloid β peptides act directly on single neurons
    • Simmons, M.A. and Schneider, C.R., Amyloid β peptides act directly on single neurons, Neurosci. Lett., 150 (1993) 133-136.
    • (1993) Neurosci. Lett. , vol.150 , pp. 133-136
    • Simmons, M.A.1    Schneider, C.R.2
  • 54
    • 0026657287 scopus 로고
    • Failure of beta-amyloid protein fragment 25-35 to cause hippocampal damage in the rat
    • Stein-Behnrens, B., Adams, K., Yeh, M. and Sapolsky, R., Failure of beta-amyloid protein fragment 25-35 to cause hippocampal damage in the rat, Neurobiol. Aging, 13 (1992) 577-579.
    • (1992) Neurobiol. Aging , vol.13 , pp. 577-579
    • Stein-Behnrens, B.1    Adams, K.2    Yeh, M.3    Sapolsky, R.4
  • 55
    • 0028353007 scopus 로고
    • Neuronal atrophy, not cell death, is the main hallmark of Alzheimer's disease
    • Swaab, D.F., Hofman, M.A., Lucassen, P.J., Salehi, A. and Uylings, H.B.M., Neuronal atrophy, not cell death, is the main hallmark of Alzheimer's disease, Neurobiol. Aging, 15 (1994) 369-371.
    • (1994) Neurobiol. Aging , vol.15 , pp. 369-371
    • Swaab, D.F.1    Hofman, M.A.2    Lucassen, P.J.3    Salehi, A.4    Uylings, H.B.M.5
  • 58
    • 0028180304 scopus 로고
    • 2+ channel blockers attenuate β-amyloid peptide toxicity to cortical neurons in culture
    • 2+ channel blockers attenuate β-amyloid peptide toxicity to cortical neurons in culture, J. Neurochem., 62 (1994) 372-375.
    • (1994) J. Neurochem. , vol.62 , pp. 372-375
    • Weiss, J.H.1    Pike, C.J.2    Cotman, C.W.3
  • 59
    • 0020072221 scopus 로고
    • Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
    • Whitehouse, P.J., Price, D.L., Struble, R.G., Clark, A.W. and Coyle, J.T., Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain, Science, 215 (1982) 1237-1239.
    • (1982) Science , vol.215 , pp. 1237-1239
    • Whitehouse, P.J.1    Price, D.L.2    Struble, R.G.3    Clark, A.W.4    Coyle, J.T.5
  • 60
    • 0024543836 scopus 로고
    • Amyloid β-protein enhances the survival of hippocampal neurons in vitro
    • Whitson, J.S., Selkoe, D.G. and Cotman, C.W., Amyloid β-protein enhances the survival of hippocampal neurons in vitro, Science, 243 (1989) 1488-1490.
    • (1989) Science , vol.243 , pp. 1488-1490
    • Whitson, J.S.1    Selkoe, D.G.2    Cotman, C.W.3
  • 62
    • 0027076549 scopus 로고
    • Strain differences of mice in learning of swimming behaviour and effect of hemicholinium and vasopressin. Observation by a simple water maze apparatus
    • Yamada, K., Satoh, M., Tokoi, J., Tsuboi, M. and Nagasaka, T., Strain differences of mice in learning of swimming behaviour and effect of hemicholinium and vasopressin. Observation by a simple water maze apparatus, Yakugaku Zasshi, 112 (1992) 824-831.
    • (1992) Yakugaku Zasshi , vol.112 , pp. 824-831
    • Yamada, K.1    Satoh, M.2    Tokoi, J.3    Tsuboi, M.4    Nagasaka, T.5
  • 64
    • 0024990330 scopus 로고
    • Neurotrophic and neurotoxic effects of amyloid β-protein: Reversal by tachykinin neuropeptides
    • Yankner, B.A., Duffy, L.K. and Kirschner, D.A., Neurotrophic and neurotoxic effects of amyloid β-protein: reversal by tachykinin neuropeptides, Science, 250 (1990) 279-282.
    • (1990) Science , vol.250 , pp. 279-282
    • Yankner, B.A.1    Duffy, L.K.2    Kirschner, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.