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Volumn 126, Issue 1, 1999, Pages 235-244

Improvement by nefiracetam of /?-amyloid-(l-42)-induced learning and memory impairments in rats

Author keywords

Alzheimer1 s disease; Amyloid ? peptide; Nefiracetam (dm 9384); Reference memory; Voltage sensitive calcium channels; Working memory

Indexed keywords

AMYLOID BETA PROTEIN; CHOLINE ACETYLTRANSFERASE; DOPAMINE; NEFIRACETAM; NOOTROPIC AGENT;

EID: 0032918505     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702309     Document Type: Article
Times cited : (90)

References (57)
  • 1
    • 0029819081 scopus 로고    scopus 로고
    • Amyloid toxicity consists of a Ca2 + -independent early phase and a Ca -dependent late phase
    • ABE, K. & KIMURA, H. (1996). Amyloid toxicity consists of a Ca2 + -independent early phase and a Ca -dependent late phase. J. Neiirochem., 67, 2074-2078.
    • (1996) J. Neiirochem. , vol.67 , pp. 2074-2078
    • Abe, K.1    Kimura, H.2
  • 2
    • 0026526401 scopus 로고
    • Effects of nefiracetam, a novel pyrrolidone derivative, on brain monoamine metabolisms in mice
    • ABE, E., MURAI, S., SAITO, H., MASUDA, Y. & ITOU, T. (1992). Effects of nefiracetam, a novel pyrrolidone derivative, on brain monoamine metabolisms in mice. J. Neural. Transm., 90, 125-136.
    • (1992) J. Neural. Transm. , vol.90 , pp. 125-136
    • Abe, E.1    Murai, S.2    Saito, H.3    Masuda, Y.4    Itou, T.5
  • 3
    • 0028177150 scopus 로고
    • Effects of nefiracetam on deficits in active avoidance response and hippocampal cholinergic and monoaminergic dysfunctions induced by AF64A in mice
    • ABE, E., MURAI, S., SAITO, H., MASUDA, Y. & ITOH, T. (1994). Effects of nefiracetam on deficits in active avoidance response and hippocampal cholinergic and monoaminergic dysfunctions induced by AF64A in mice. J. Neural. Transm., 95, 179-193.
    • (1994) J. Neural. Transm. , vol.95 , pp. 179-193
    • Abe, E.1    Murai, S.2    Saito, H.3    Masuda, Y.4    Itoh, T.5
  • 5
    • 0026699777 scopus 로고
    • Implants containing beta-amyloid protein are not neurotoxic to young and old rat brain
    • CLEMENS, J.A. & STEPHENSON, D.T. (1992). Implants containing beta-amyloid protein are not neurotoxic to young and old rat brain. Neurobiol. Aging, 13, 581-586.
    • (1992) Neurobiol. Aging , vol.13 , pp. 581-586
    • Clemens, J.A.1    Stephenson, D.T.2
  • 6
    • 0028173077 scopus 로고
    • An amyloid -protein fragment, A/î[12-28] equipotently impairs post-training memory processing when injected into different limbic structures
    • FLOOD, J.F., MORLEY, J.E. & ROBERTS, E. (1994). An amyloid -protein fragment, A/î[12-28] equipotently impairs post-training memory processing when injected into different limbic structures. Brain Res., 663, 271-276.
    • (1994) Brain Res. , vol.663 , pp. 271-276
    • Flood, J.F.1    Morley, J.E.2    Roberts, E.3
  • 7
    • 0031014448 scopus 로고    scopus 로고
    • Ionic effects of Alzheimer1 s disease /J-amyloid precursor protein and its metabolic fragments
    • FRASER, S.P., SUY, Y.-H. & DJAMGOS M.B.A. (1997). Ionic effects of Alzheimer1 s disease /J-amyloid precursor protein and its metabolic fragments. Trends Neurosci., 20, 67-72.
    • (1997) Trends Neurosci. , vol.20 , pp. 67-72
    • Fraser, S.P.1    Suy, Y.-H.2    Djamgos, M.B.A.3
  • 8
    • 0028954228 scopus 로고
    • Age-related spatial reference and working memory deficits assessed in the water maze
    • FRICK, K., BAXTER, M.G., MARKOWSKA, A.L., OLTON, D.S. & PRICE, D.L. (1995). Age-related spatial reference and working memory deficits assessed in the water maze. Neurobiol. Aging, 16, 149-160.
    • (1995) Neurobiol. Aging , vol.16 , pp. 149-160
    • Frick, K.1    Baxter, M.G.2    Markowska, A.L.3    Olton, D.S.4    Price, D.L.5
  • 9
    • 0027195907 scopus 로고
    • Effects of repeated administration of propentofylline on memory impairment produced by basal forebrain lesion in rats
    • FUJI, K., HIRAMATSU, M., KAMEYAMA, T. & NABESHIMA, T. (1993). Effects of repeated administration of propentofylline on memory impairment produced by basal forebrain lesion in rats. Eur. J. Pharmacol., 236, 411 -417.
    • (1993) Eur. J. Pharmacol. , vol.236 , pp. 411-417
    • Fuji, K.1    Hiramatsu, M.2    Kameyama, T.3    Nabeshima, T.4
  • 12
    • 0029070173 scopus 로고
    • Differential effects of amyloid peptides /?-( 1 -40) and /5-(25-35) injections into the rat nucleus basalis
    • GIOVANNELLI, L., CASAMENTI, F., SCALI, C., BARTOLINI, L. & PEPEU, G. ( 1995). Differential effects of amyloid peptides /?-( 1 -40) and /5-(25-35) injections into the rat nucleus basalis. Neuroscience, 66, 781-792.
    • (1995) Neuroscience , vol.66 , pp. 781-792
    • Giovannelli, L.1    Casamenti, F.2    Scali, C.3    Bartolini, L.4    Pepeu, G.5
  • 14
    • 0026770881 scopus 로고
    • Involvement of the cholinergic system in the effects of nefiracetam (DM-9384) on carbon monoxide (CO)-induced acute and delayed amnesia
    • HIRAMATSU, M., KOIDE, T., ISHIHARA, S., SHIOTANI, T., KAMEYAMA, T. & NABESHIMA, T. (1992). Involvement of the cholinergic system in the effects of nefiracetam (DM-9384) on carbon monoxide (CO)-induced acute and delayed amnesia. Enr. J. Pharmacol., 216, 279-285.
    • (1992) Enr. J. Pharmacol. , vol.216 , pp. 279-285
    • Hiramatsu, M.1    Koide, T.2    Ishihara, S.3    Shiotani, T.4    Kameyama, T.5    Nabeshima, T.6
  • 16
    • 0030444046 scopus 로고    scopus 로고
    • Effects of the nootropic drug nefiracetam on the GABAA receptor-channel complex in dorsal root ganglion neurons
    • HUANG, C.S., MA, J.Y., MARSZALEC, W. & NARAHASHI, T. (1996). Effects of the nootropic drug nefiracetam on the GABAA receptor-channel complex in dorsal root ganglion neurons. Neiiropharmacology, 35, 1251-1261.
    • (1996) Neiiropharmacology , vol.35 , pp. 1251-1261
    • Huang, C.S.1    J.y, M.A.2    Marszalec, W.3    Narahashi, T.4
  • 17
    • 0030038473 scopus 로고    scopus 로고
    • Dysfunction of cholinergic and dopaminergic neuronal systems in -amyloid protein-infused rats
    • ITOH, A., N1TTA, A., NADAI, M., NISHIMURA, K., HIROSE, M., HASEGAWA, T. & NABESHIMA, T. (1996). Dysfunction of cholinergic and dopaminergic neuronal systems in -amyloid protein-infused rats. J. Nciiroclicin., 66, 1113- 1117.
    • (1996) J. Nciiroclicin. , vol.66 , pp. 1113-1117
    • Itoh, A.1    Ntta, A.2    Nadai, M.3    Nishimura, K.4    Hirose, M.5    Hasegawa, T.6    Nabeshima, T.7
  • 18
    • 0028169925 scopus 로고
    • Visualization of A/i42(43) and A/i40 in senile plaques with end-specific A monoclonals: Evidence that an initially deposited species is A/?42(43)
    • IWATSUBO, T., ODAKA, A., SUZUKI, N., MIZUSAWA, H., NUKINA, N. & IHARA, Y. (1994). Visualization of A/i42(43) and A/i40 in senile plaques with end-specific A monoclonals: evidence that an initially deposited species is A/?42(43). Neuron, 13, 45-53.
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 19
    • 0027195933 scopus 로고
    • JARRETT, J.T. & LANSBURY, JR, P.T. (1993). Seedling 1 onedimensional crystallization1 of amyloid: a pathogenic mechanism in Alzheimer1 s disease and scrapie? Cell, 73, 1055-1058.
    • (1993) Seedling , vol.1
    • Jarrett, J.T.1    Lansbury, J.R.2
  • 21
    • 0021965716 scopus 로고
    • Highly sensitive assay for choline acetyltransferase activity by high-performance liquid chromatography with electromechanical detection
    • KANEDA, N. & NAGATSU, T. (1985). Highly sensitive assay for choline acetyltransferase activity by high-performance liquid chromatography with electromechanical detection. J. Chromatogr., 341,23-30.
    • (1985) J. Chromatogr. , pp. 23-30
    • Kaneda, N.1    Nagatsu, T.2
  • 23
    • 0028173017 scopus 로고
    • Nefiracetam enhances acetylcholine outflow from the frontal cortex: In vivo microdialysis study in the rat
    • KAWAJIRI, S., TANIGUCHI, K., SAKURAI, T. & YAMAZAKI, T. (1994). Nefiracetam enhances acetylcholine outflow from the frontal cortex: in vivo microdialysis study in the rat. J. Neural. Transm.,98, 15-22.
    • (1994) J. Neural. Transm. , vol.98 , pp. 15-22
    • Kawajiri, S.1    Taniguchi, K.2    Sakurai, T.3    Yamazaki, T.4
  • 24
    • 0025110182 scopus 로고
    • KOH, J.-Y., YANG, L.L. & COTMAN, C.W. (1990). /?-amy!oid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res., 533, 315-320.
    • (1990) Brain Res. , vol.533 , pp. 315-320
    • Koh, J.-Y.1    Yang, L.L.2    Cotman, C.W.3
  • 25
    • 0025879957 scopus 로고
    • An in vivo model for the neurodegenerative effects of /J-amyloid and protection by substance P
    • KOWALL, W.N., BEAL, P.M., BUSCIGLIO, J., DUFFY, K.L. & YANKNER, B.A. (1991). An in vivo model for the neurodegenerative effects of /J-amyloid and protection by substance P. Proc. Natl. Acad. Sei. U.S.A., 88, 7247-7251.
    • (1991) Proc. Natl. Acad. Sei. U.S.A. , vol.88 , pp. 7247-7251
    • Kowall, W.N.1    Beal, P.M.2    Busciglio, J.3    Duffy, K.L.4    Yankner, B.A.5
  • 28
    • 0030048606 scopus 로고    scopus 로고
    • Amnesia induced by centrally administered -amyloid peptides involves cholinergic dysfunction
    • MAURICE, T., LOCKHART. B.P. & PRIVAT, A (1996). Amnesia induced by centrally administered -amyloid peptides involves cholinergic dysfunction. Brain Res., 706, 181 - 193.
    • (1996) Brain Res. , vol.706 , pp. 181-193
    • Maurice, T.1    Lockhart, B.P.2    Privat, A.3
  • 29
    • 0021173996 scopus 로고
    • Developments of water-maze procedure for studying spatial learning in the rat
    • MORRIS, R.G.M. (1984). Developments of water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods, 11,4760.
    • (1984) J. Neurosci. Methods , pp. 4760
    • Morris, R.G.M.1
  • 30
    • 0027984961 scopus 로고
    • Ameliorating effects of nefiracetam (DM9384) on brain dysfunction
    • NABESHIMA, T. (1994). Ameliorating effects of nefiracetam (DM9384) on brain dysfunction. Drugs Today, 30, 357-379.
    • (1994) Drugs Today , vol.30 , pp. 357-379
    • Nabeshima, T.1
  • 32
    • 0028207467 scopus 로고
    • Effects of nefiracetam on drug-induced impairment of latent learning in mice in a water finding task
    • NABESHIMA, T., NAKAYAMA, S., ICHIHARA, K., YAMADA, K., SHIOTANI, T. & HASEGAWA, T. (1994). Effects of nefiracetam on drug-induced impairment of latent learning in mice in a water finding task. Eur. J. Pharmacol., 255: 57-65.
    • (1994) Eur. J. Pharmacol. , vol.255 , pp. 57-65
    • Nabeshima, T.1    Nakayama, S.2    Ichihara, K.3    Yamada, K.4    Shiotani, T.5    Hasegawa, T.6
  • 33
    • 0028544333 scopus 로고
    • Memory impairment and neuronal dysfunction induced by /î-amyloid protein in rats
    • NABESHIMA, T. & N1TTA, A. (1994). Memory impairment and neuronal dysfunction induced by /î-amyloid protein in rats. Tohoku J. Exp. Med., 174, 241 -249.
    • (1994) Tohoku J. Exp. Med. , vol.174 , pp. 241-249
    • Nabeshima, T.1    Nitta, A.2
  • 34
    • 0025309740 scopus 로고
    • Effects of DM-9384 in a model of amnesia based on animals with GABAergic neuronal dysfunctions
    • NABESHIMA, T., NODA, Y., TOHYAMA, K., ITOH, J. & KAMEYAMA, T. (1990). Effects of DM-9384 in a model of amnesia based on animals with GABAergic neuronal dysfunctions. Eur. J. Pharmacol.. 178, 143-149.
    • (1990) Eur. J. Pharmacol.. , vol.178 , pp. 143-149
    • Nabeshima, T.1    Noda, Y.2    Tohyama, K.3    Itoh, J.4    Kameyama, T.5
  • 37
  • 38
    • 0031051960 scopus 로고    scopus 로고
    • Continuous infusion of/î-amyloid protein into cerebral ventricle induces learning impairment and neuronal and morphological degeneration
    • NITTA, A., FUKUTA, T., HASEGAWA, T. & NABESHIMA, T. (1997). Continuous infusion of/î-amyloid protein into cerebral ventricle induces learning impairment and neuronal and morphological degeneration. Jpn. J. Pharmacol., 73, 51-57.
    • (1997) Jpn. J. Pharmacol. , vol.73 , pp. 51-57
    • Nitta, A.1    Fukuta, T.2    Hasegawa, T.3    Nabeshima, T.4
  • 39
    • 0028177692 scopus 로고
    • Amyloid protein-induced Alzheimer1 s disease animal model
    • NITTA, A., ITOH, A., HASEGAWA, T. & NABESHIMA, T. (1994). /?Amyloid protein-induced Alzheimer1 s disease animal model. Neitrosci. Lett., 170, 63-66.
    • (1994) Neitrosci. Lett. , vol.170 , pp. 63-66
    • Nitta, A.1    Itoh, A.2    Hasegawa, T.3    Nabeshima, T.4
  • 41
    • 0032562553 scopus 로고    scopus 로고
    • Nefiracetam elevates extracellular acetylcholine level in the frontal cortex of rats with cerebral dysfunctions: An in vivo microdialysis study
    • SAKURAI, T., KATO, T., MORI, K., TAKANO, E., WATABE, S. & NABESHIMA, T. (1998). Nefiracetam elevates extracellular acetylcholine level in the frontal cortex of rats with cerebral dysfunctions: an in vivo microdialysis study. Neurosci. Lett., 246, 69-72.
    • (1998) Neurosci. Lett. , vol.246 , pp. 69-72
    • Sakurai, T.1    Kato, T.2    Mori, K.3    Takano, E.4    Watabe, S.5    Nabeshima, T.6
  • 42
    • 0025350664 scopus 로고
    • Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells
    • SHINODA, I., FURUKAWA, Y. & FURUKAWA, S. (1990). Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells. Biochem. Pharmacol., 49, 18131816.
    • (1990) Biochem. Pharmacol. , vol.49 , pp. 1813-1816
    • Shinoda, I.1    Furukawa, Y.2    Furukawa, S.3
  • 46
    • 0031879794 scopus 로고    scopus 로고
    • NC-1900, an active fragment analog of arginine vasopressin, improves learning and memory deficits induced by /î-amyloid protein in rats
    • TANAKA, T., YAMADA, K., SENZAKI, K., NARIMATSU, H., NISHIMURA, K., KAMEYAMA, T. & NABESHIMA, T. (1998). NC-1900, an active fragment analog of arginine vasopressin, improves learning and memory deficits induced by /î-amyloid protein in rats. Eur. J. Pharmacol., 352, 135-142.
    • (1998) Eur. J. Pharmacol. , vol.352 , pp. 135-142
    • Tanaka, T.1    Yamada, K.2    Senzaki, K.3    Narimatsu, H.4    Nishimura, K.5    Kameyama, T.6    Nabeshima, T.7
  • 47
    • 0027209321 scopus 로고
    • DM-9384, a new cognition-enhancing agent, increases the turnover of components of the GABAergic system in the rat cerebral cortex
    • WATABE, S., YAMAGUCHI, H. & ASHIDA, S. (1993). DM-9384, a new cognition-enhancing agent, increases the turnover of components of the GABAergic system in the rat cerebral cortex. Eur. J. Pharmacol., 238, 303-309.
    • (1993) Eur. J. Pharmacol. , vol.238 , pp. 303-309
    • Watabe, S.1    Yamaguchi, H.2    Ashida, S.3
  • 48
    • 0028180304 scopus 로고
    • Ca2+ channel blockers attenuate -amyloid peptide toxicity to cortical neurons in culture
    • WEISS, J.H., PIKE, C.J. & COTMAN, C.W. (1994). Ca2+ channel blockers attenuate -amyloid peptide toxicity to cortical neurons in culture. J. Neurochem., 62, 372-375.
    • (1994) J. Neurochem. , vol.62 , pp. 372-375
    • Weiss, J.H.1    Pike, C.J.2    Cotman, C.W.3
  • 50
    • 0029960372 scopus 로고    scopus 로고
    • Nefiracetam (DM-9384): A novel antiamnesic drug
    • YAMADA, K. & NABESHIMA, T. (1996). Nefiracetam (DM-9384): a novel antiamnesic drug. CNS Drug Rev., 2, 322-342.
    • (1996) CNS Drug Rev. , vol.2 , pp. 322-342
    • Yamada, K.1    Nabeshima, T.2
  • 51
    • 0027998290 scopus 로고
    • Possible involvement of the activation of voltage-sensitive calcium channels in the ameliorating effects of nefiracetam on scopolamine-induced impairment of performance in a passive avoidance task
    • YAMADA, K., NAKAYAMA, S., SHIOTANI, T., HASEGAWA, T. & NABESHIMA, T. (1994). Possible involvement of the activation of voltage-sensitive calcium channels in the ameliorating effects of nefiracetam on scopolamine-induced impairment of performance in a passive avoidance task. J. Pharmacol. Exp. Ther., 270, 881 892.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 881-892
    • Yamada, K.1    Nakayama, S.2    Shiotani, T.3    Hasegawa, T.4    Nabeshima, T.5
  • 52
    • 0028802698 scopus 로고
    • Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid (1-40) protein
    • YAMADA, K.., NITTA, A., SAITO, T., HU, J. & NABESHIMA, T. (1995a). Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid (1-40) protein. Neurosci. Lett., 201, 155-158.
    • (1995) Neurosci. Lett. , vol.201 , pp. 155-158
    • Yamada, K.1    Nitta, A.2    Saito, T.3    Nabeshima, T.4
  • 54
    • 0030088028 scopus 로고    scopus 로고
    • The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behaviour in mice
    • YAMADA, K., NODA, Y., HASEGAWA, T., KOMORI, Y., NIKAI, T., SUGIHARA, H. & NABESHIMA,T. (1996). The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behaviour in mice. J. Pharmacol. Exp. Ther., 276, 460 -466.
    • (1996) J. Pharmacol. Exp. Ther. , vol.276 , pp. 460-466
    • Yamada, K.1    Noda, Y.2    Hasegawa, T.3    Komori, Y.4    Nikai, T.5    Sugihara, H.6    Nabeshima, T.7
  • 55
    • 0032524558 scopus 로고    scopus 로고
    • Propentofylline improves learning and memory deficits in rats induced by /î-amyloid protein-(l-40)
    • YAMADA, K., TANAKA, T., SENZAKI, K., KAMEYAMA, T. & NABESHIMA, T. (1998). Propentofylline improves learning and memory deficits in rats induced by /î-amyloid protein-(l-40). Eur. J. Plmrinacol.,349, 15-22.
    • (1998) Eur. J. Plmrinacol. , vol.349 , pp. 15-22
    • Yamada, K.1    Tanaka, T.2    Senzaki, K.3    Kameyama, T.4    Nabeshima, T.5
  • 56
    • 0024990330 scopus 로고
    • Neurotrophic and neurotoxic effects of amyloid protein: Reversla by tachykinin neuropeptides
    • YANKNER, B.A., DUFFY, L.K. & KIRSCHNER, D.A. (1990). Neurotrophic and neurotoxic effects of amyloid protein: reversla by tachykinin neuropeptides. Science, 250, 279-282.
    • (1990) Science , vol.250 , pp. 279-282
    • Yankner, B.A.1    Duffy, L.K.2    Kirschner, D.A.3
  • 57
    • 0028297182 scopus 로고
    • Enhancement of neuronal calcium channel currents by the nootropic agent, nefiracetam (DM-9384), in NG108-15 cells
    • YOSHII, M. & WATABE, S. (1994). Enhancement of neuronal calcium channel currents by the nootropic agent, nefiracetam (DM-9384), in NG108-15 cells. Brain Res.. 642, 123-131.
    • (1994) Brain Res.. , vol.642 , pp. 123-131
    • Yoshii, M.1    Watabe, S.2


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