Common structural features determine the effectiveness of carvedilol, daunomycin and rolitetracycline as inhibitors of Alzheimer β-amyloid fibril formation

Biochemical Journal

Volumn 343, Issue 2, 1999, Pages 419-423

  Howlett, David R ^a   George, Ashley R ^a,b   Owen, Davina E ^a   Ward, Robin V ^a   Markwell, Roger E ^a  

^a SmithKline Beecham ^*  (United Kingdom)

^b Cerebrus Limited   (United Kingdom)

Author keywords

Alzheimer's disease; Carbazoles; Three dimensional pharmacophore

Indexed keywords

AMYLOID BETA PROTEIN; CARVEDILOL; DAUNORUBICIN; ROLITETRACYCLINE;

ALZHEIMER DISEASE; ARTICLE; CYTOTOXICITY; DRUG PROTEIN BINDING; FIBER; HUMAN; HUMAN CELL; MOLECULAR MODEL; NEUROBLASTOMA CELL; PEPTIDE SYNTHESIS; PHARMACOPHORE; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CARBAZOLES; CELL SURVIVAL; DAUNORUBICIN; HUMANS; INHIBITORY CONCENTRATION 50; MICROSCOPY, ELECTRON; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NEURONS; POLYMERS; PROPANOLAMINES; PROTEIN BINDING; ROLITETRACYCLINE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLIUM SALTS; THERMODYNAMICS; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0033569444     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3430419     Document Type: Article

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