메뉴 건너뛰기




Volumn 56, Issue 9, 1997, Pages 965-973

APP(Sw) transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1

Author keywords

Alzheimer disease; Amyloid precursor protein; Amyloid protein; Hippocampus; mRNA; Synaptophysin; Transgenic models

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; MESSENGER RNA; SYNAPTOPHYSIN;

EID: 0030612033     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199709000-00002     Document Type: Article
Times cited : (582)

References (39)
  • 1
    • 0028123071 scopus 로고
    • Alzheimer's disease: A central role for amyloid
    • Selkoe D. Alzheimer's disease: A central role for amyloid. J Neuropathol Exp Neural 1994;53:438-47
    • (1994) J Neuropathol Exp Neural , vol.53 , pp. 438-447
    • Selkoe, D.1
  • 2
    • 0025110182 scopus 로고
    • β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage
    • Koh J-Y, Yang L-L, Cotman CW. β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res 1990;533:315-20
    • (1990) Brain Res , vol.533 , pp. 315-320
    • Koh, J.-Y.1    Yang, L.-L.2    Cotman, C.W.3
  • 3
    • 0026570528 scopus 로고
    • Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • Mattson MP, Cheng B, Davis D. Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 1992;12:379-89
    • (1992) J Neurosci , vol.12 , pp. 379-389
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3
  • 4
    • 0027447286 scopus 로고
    • Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
    • Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state. J Neurosci 1993;13:1676-87
    • (1993) J Neurosci , vol.13 , pp. 1676-1687
    • Pike, C.J.1    Burdick, D.2    Walencewicz, A.J.3    Glabe, C.G.4    Cotman, C.W.5
  • 6
    • 0029964207 scopus 로고    scopus 로고
    • Amyloid fibril toxicity in Alzheimer's disease and diabetes
    • Yankner BA, Lorenzo A. Amyloid fibril toxicity in Alzheimer's disease and diabetes. Ann New York Acad Sci 1996;777:89-95
    • (1996) Ann New York Acad Sci , vol.777 , pp. 89-95
    • Yankner, B.A.1    Lorenzo, A.2
  • 9
    • 0026657287 scopus 로고
    • Failure of beta-amyloid protein fragment 25-35 to cause hippocampal damage in the rat
    • Stein-Beherns B, Adams K, Yen M, Sapolsky R. Failure of beta-amyloid protein fragment 25-35 to cause hippocampal damage in the rat. Neurobiol Aging 1992;13:577-79
    • (1992) Neurobiol Aging , vol.13 , pp. 577-579
    • Stein-Beherns, B.1    Adams, K.2    Yen, M.3    Sapolsky, R.4
  • 10
    • 0027490070 scopus 로고
    • The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution
    • Hyman BT, Marzloff K, Arriagada PV. The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. J Neuropath Exp Neurol 1993;52:594-600
    • (1993) J Neuropath Exp Neurol , vol.52 , pp. 594-600
    • Hyman, B.T.1    Marzloff, K.2    Arriagada, P.V.3
  • 11
    • 0028831582 scopus 로고
    • Relative roles of plaques and tangles in the dementia of Alzheimer's disease: Correlations using three sets of neuropathological criteria
    • Nagy Z, Esiri MM, Jobst KA. Relative roles of plaques and tangles in the dementia of Alzheimer's disease: Correlations using three sets of neuropathological criteria. Dementia 1995;6:21-31
    • (1995) Dementia , vol.6 , pp. 21-31
    • Nagy, Z.1    Esiri, M.M.2    Jobst, K.A.3
  • 12
    • 0030050286 scopus 로고    scopus 로고
    • Clinical and pathological correlates of apolipoprotein E e4 in Alzheimer's disease
    • Gomez-Isla T, West HL, Rebeck GW, et al. Clinical and pathological correlates of apolipoprotein E e4 in Alzheimer's disease. Ann Neurol 1996;39:62-70
    • (1996) Ann Neurol , vol.39 , pp. 62-70
    • Gomez-Isla, T.1    West, H.L.2    Rebeck, G.W.3
  • 13
    • 0029979798 scopus 로고    scopus 로고
    • Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
    • Gomez-Isla T, Price J, McKeel D, Morris J, Growdon J, Hyman B. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 1996;16:4491-4500
    • (1996) J Neurosci , vol.16 , pp. 4491-4500
    • Gomez-Isla, T.1    Price, J.2    McKeel, D.3    Morris, J.4    Growdon, J.5    Hyman, B.6
  • 14
    • 0344653664 scopus 로고    scopus 로고
    • Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
    • Gomez-Isla T, Hollister R, West H, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 1997;41:17-24
    • (1997) Ann Neurol , vol.41 , pp. 17-24
    • Gomez-Isla, T.1    Hollister, R.2    West, H.3
  • 15
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice
    • Hsiao K, Chapman P. Nilsen S, et al. Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice. Science 1996;274:99-102
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3
  • 17
    • 0030459831 scopus 로고    scopus 로고
    • In situ hybridization analysis of presenilin 1 mRNA in Alzheimer's disease and in lesioned rat brain
    • Page K, Hollister R, Tanzi RE, Hyman BT. In situ hybridization analysis of presenilin 1 mRNA in Alzheimer's disease and in lesioned rat brain. Proc Natl Acad Sci USA 1996;93:14020-24
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14020-14024
    • Page, K.1    Hollister, R.2    Tanzi, R.E.3    Hyman, B.T.4
  • 18
    • 0027500468 scopus 로고
    • Differential regional and cellular distribution of beta-amyloid precursor protein messenger RNAs containing and lacking the Kunitz protease inhibitor domain in the brain of human, rat and mouse
    • Sola C, Mengod G, Probst A, Palacios JM. Differential regional and cellular distribution of beta-amyloid precursor protein messenger RNAs containing and lacking the Kunitz protease inhibitor domain in the brain of human, rat and mouse. Neuroscience 1993;53: 267-95
    • (1993) Neuroscience , vol.53 , pp. 267-295
    • Sola, C.1    Mengod, G.2    Probst, A.3    Palacios, J.M.4
  • 19
    • 0026646604 scopus 로고
    • Amyloid beta-peptide is produced by cultured cells during normal metabolism
    • Haass C, Schlossmacher MG, Hung AY, et al. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 1992;359:322-25
    • (1992) Nature , vol.359 , pp. 322-325
    • Haass, C.1    Schlossmacher, M.G.2    Hung, A.Y.3
  • 20
    • 0024550204 scopus 로고
    • Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
    • Weidemann A, Konig G, Bunke D, et al. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 1989;57:115-26
    • (1989) Cell , vol.57 , pp. 115-126
    • Weidemann, A.1    Konig, G.2    Bunke, D.3
  • 22
    • 0025327731 scopus 로고
    • Unbiased stereological estimation of the number of neurons in the human hippocampus
    • West MJ, Gundersen HJG. Unbiased stereological estimation of the number of neurons in the human hippocampus. J Comp Neurol 1990;296:1-22
    • (1990) J Comp Neurol , vol.296 , pp. 1-22
    • West, M.J.1    Gundersen, H.J.G.2
  • 24
    • 0003031577 scopus 로고
    • Denber WN, Richman LL, eds. Springer-Verlag: New York.
    • Douglas RJ. Spontaneous alternation behavior. Denber WN, Richman LL, eds. Springer-Verlag: New York. 1990:73-109
    • (1990) Spontaneous Alternation Behavior , pp. 73-109
    • Douglas, R.J.1
  • 25
    • 0028122463 scopus 로고
    • Differences in the pattern of hippocampal neuron loss in normal ageing and Alzheimer's disease
    • West MJ. Differences in the pattern of hippocampal neuron loss in normal ageing and Alzheimer's disease. Lancet 1994;344:769-72
    • (1994) Lancet , vol.344 , pp. 769-772
    • West, M.J.1
  • 26
    • 0024439528 scopus 로고
    • Expression of neuronal mRNAs in Alzheimer type degeneration of the nervous system
    • Clark AW, Parhad IM. Expression of neuronal mRNAs in Alzheimer type degeneration of the nervous system. Can J Neurol Sci 1989;16:477-82
    • (1989) Can J Neurol Sci , vol.16 , pp. 477-482
    • Clark, A.W.1    Parhad, I.M.2
  • 27
    • 0028023533 scopus 로고
    • Functional alterations in Alzheimer's disease: Selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation
    • Simonian NA, Hyman BT. Functional alterations in Alzheimer's disease: Selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation. J Neuropath Exp Neurol 1994;53:508-12
    • (1994) J Neuropath Exp Neurol , vol.53 , pp. 508-512
    • Simonian, N.A.1    Hyman, B.T.2
  • 28
    • 0028989895 scopus 로고
    • Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease
    • Callahan LM, Coleman PD. Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease. Neurobiol Aging 1995;16:311-14
    • (1995) Neurobiol Aging , vol.16 , pp. 311-314
    • Callahan, L.M.1    Coleman, P.D.2
  • 29
    • 0028865363 scopus 로고
    • Aberrant GAP-43 gene expression in Alzheimer's disease
    • de la Monte SM, Ng S-C, Hsu DW. Aberrant GAP-43 gene expression in Alzheimer's disease. Am J Pathol 1995;147:934-46
    • (1995) Am J Pathol , vol.147 , pp. 934-946
    • De La Monte, S.M.1    Ng, S.-C.2    Hsu, D.W.3
  • 31
    • 0024561501 scopus 로고
    • Cytochrome oxidase: An endogenous metabolic marker of neuronal activity
    • Wong-Riley MTT; Cytochrome oxidase: An endogenous metabolic marker of neuronal activity. Trends Neurosci 1989;12:94-101
    • (1989) Trends Neurosci , vol.12 , pp. 94-101
    • Wong-Riley, M.1
  • 32
    • 0025000082 scopus 로고
    • The role of afferent activity in the maintenance of primate neocortical function
    • Jones EG. The role of afferent activity in the maintenance of primate neocortical function. J Exp Biol 1990;153:155-76
    • (1990) J Exp Biol , vol.153 , pp. 155-176
    • Jones, E.G.1
  • 33
    • 0022535539 scopus 로고
    • Perforant pathway changes and the memory impairment of Alzheimer's disease
    • Hyman BT, Van Hoesen GW, Kromer LJ, Damasio AR. Perforant pathway changes and the memory impairment of Alzheimer's disease. Ann Neurol 1986;20:473-82
    • (1986) Ann Neurol , vol.20 , pp. 473-482
    • Hyman, B.T.1    Van Hoesen, G.W.2    Kromer, L.J.3    Damasio, A.R.4
  • 35
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate A, Chartier-Harlin M-C, Mullan M. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991;349:704-7
    • (1991) Nature , vol.349 , pp. 704-707
    • Goate, A.1    Chartier-Harlin, M.-C.2    Mullan, M.3
  • 36
    • 0026907151 scopus 로고
    • A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
    • Mullan M, Crawford F, Axelman K, et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nature Genetics 1992;1:345-47
    • (1992) Nature Genetics , vol.1 , pp. 345-347
    • Mullan, M.1    Crawford, F.2    Axelman, K.3
  • 37
    • 0028810244 scopus 로고
    • Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins
    • Hsiao KK, Borchelt DR, Olson K, et al. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 1995;15:1203-18
    • (1995) Neuron , vol.15 , pp. 1203-1218
    • Hsiao, K.K.1    Borchelt, D.R.2    Olson, K.3
  • 38
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
    • Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 1995;373:523-27
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1    Adams, D.2    Alessandrini, R.3
  • 39
    • 1842351738 scopus 로고    scopus 로고
    • Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the PDAPP transgenic mice
    • Forthcoming
    • Irizarry MC, Soriano F, McNamara M, et al. Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the PDAPP transgenic mice. J Neurosci 1997. Forthcoming.
    • (1997) J Neurosci
    • Irizarry, M.C.1    Soriano, F.2    McNamara, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.