Interleukin-12 in infectious diseases

Clinical Microbiology Reviews

Volumn 10, Issue 4, 1997, Pages 611-636

  Romani, Luigina ^a   Puccetti, Paolo ^b   Bistoni, Francesco ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12;

BACTERIAL INFECTION; EXPERIMENTAL MODEL; HELPER CELL; IMMUNOREGULATION; INFECTION CONTROL; MYCOSIS; PARASITOSIS; PHAGOCYTE; REVIEW; VIRUS INFECTION;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0030690378     PISSN: 08938512     EISSN: None     Source Type: Journal    
DOI: 10.1128/cmr.10.4.611     Document Type: Review

References (476)

1. Afonso, L. C. C., T. M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235-237.
2. Akridge, R. E., and S. G. Reed. 1996. Interleukin-12 decreases human immunodeficiency virus type 1 replication in human macrophage cultures reconstituted with autologous peripheral blood mononuclear cells. J. Infect. Dis. 173:559-564.
3. Aliberti, J. C. S., M. A. G. Cardoso, G. A. Martins, R. T. Gazzinelli, L. Q. Vieira, and J. A. Silva. 1996. Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes. Infect. Immun. 64:1961-1967.
4. Allendoerfer, R., G. P. Biovin, and G. S. Deepe, Jr. 1997. Modulation of immune responses in murine pulmonary histoplasmosis. J. Infect. Dis. 175: 905-914.
5. Anguita, J., D. H. Persing, M. Rincon, S. W. Barthold, and E. Fikrig. 1996. Effect of anti-interleukin 12 treatment on murine lyme borreliosis. J. Clin. Invest. 97:1028-1234.
6. Appelberg, R., A. G. Castro, J. Pedrosa, R. A. Silva, I. M. Orme, and P. Minóprio. 1994. Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection. Infect. Immun. 62:3962-3971.
7. Arai, T., K. Hiromatsu, H. Nishimura, Y. Kimura, N. Kobayashi, H. Ishida, Y. Nimura, and Y. Yoshikai. 1995. Effects of in vivo administration of anti-IL-10 monoclonal antibody on the host defence mechanism against murine Salmonella infection. Immunology 85:381-388.
8. Autenrieth, I. B., M. Beer, E. Bohn, S. H. E. Kaufmann, and J. Heeseman. 1994. Immune responses to Yersinia enterocolitica in susceptible BALB/c and resistant C57BL/6 mice: an essential role for gamma interferon. Infect. Immun. 62:2590-2599.
9. Autenrieth, I. B., and J. Heeseman. 1992. In vivo neutralization of tumor necrosis factor alpha and interferon-gamma abrogates resistance to Yersinia enterocolitica in mice. Med. Microbiol. Immunol. 181:333-338.
10. Autenrieth, I. B., A. Tingle, A. Reske Kunz, and J. Heeseman. 1992. T lymphocytes mediate protection against Yersinia enterocolitica in mice: characterization of murine T-cell clones specific for Y. enterocolitica. Infect. Immun. 60:1140-1149.
11. Bacellar, O., C. Brodskyn, J. Guerreiro, M. Barral-Netto, C. H. Costa, R. L. Coffman, W. D. Johnson, and E. M. Carvalho. 1996. Interleukin-12 restores interferon-γ production and cytotoxic responses in visceral leishmaniasis. J. Infect. Dis. 173:1515-1516.
12. Bacon, C. M., D. W. McVicar, J. R. Ortaldo, R. C. Rees, J. J. O'Shea, and J. A. Johnston. 1995. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181:399-404.
13. Badaro, R., E. Falcoff, F. S. Badaro, E. M. Carvalho, D. Pedral-Sampaio, A. Barral, J. S. Carvalho, M. Barral-Netto, M. Brandely, L. Silva, J. C. Bina, R. Teixeira, R. Falcoff, H. Rocha, J. L. Ho, and W. D. Johnston. 1990. Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. N. Engl. J. Med. 322:16-21.
14. Balter, M. 1995. Cytokines move from margins into the spotlight. Science 268:203-206.
15. Barnes, P. F., D. Chatterjee, J. S. Abrams, S. Lu, E. Wang, M. Yamamura, P. J. Brennan, and R. L. Modlin. 1992. Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure. J. Immunol. 149:541-547.
16. Barnes, P. F., S. Lu, J. S. Abrams, E. Wang, M. Yamamura, and R. L. Modlin. 1993. Cytokine production at the site of disease in human tuberculosis. Infect. Immun. 61:3482-3489.
17. Barthold, S. W., D. S. Beck, G. M. Hansen, G. A. Terwilliger, and K. D. Moody. 1990. Lyme borreliosis in selected strains and ages of laboratory rats. J. Infect. Dis. 162:133-138.
18. Barthold, S. W., D. H. Persing, A. L. Armstrong, and R. A. Peeples. 1991. Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice. Am. J. Pathol. 139:263-273.
19. Bellone, G., and G. Trinchieri. 1994. Dual stimulatory and inhibitory effect of NK cell stimulatory factor/IL-12 on human hematopoiesis. J. Immunol. 153:930-937.
20. Bendelac, A., and D. T. Fearon. 1997. Editorial overview: innate pathways that control acquired immunity. Curr. Opin. Immunol. 9:1-3.
21. Bermudez, L. E., M. Wu, and L. S. Young. 1995. Interleukin-12-stimulated natural killer cells can activate human macrophages to inhibit growth of Mycobacterium avium. Infect. Immun. 63:4099-4104.
22. Bernhisel-Broadbent, J., E. E. Camargo, H. S. Jaffe, and H. M. Lederman. 1991. Recombinant human interferon-γ as adjunct therapy for Aspergillus infection in a patient with chronic granulomatous disease. J. Infect. Dis. 163:908-911.
23. Bi, Z., P. Quandt, T. Komatsu, M. Barna, and C. S. Reiss. 1995. IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system. J. Immunol. 155:5684-5689.
24. Biron, C. A. 1994. Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr. Opin. Immunol. 6:530-538.
25. Biron, C. A., and R. T. Gazzinelli. 1995. Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr. Opin. Immunol. 7:485-496.
26. Biron, C. A., and J. S. Orange. 1995. IL12 in acute viral infectious disease. Res. Immunol. 146:590-599.
27. Blanden, R. V., M. J. Lefford, and G. B. Mackaness. 1969. The host response to Calmette-Guérin bacillus infection in mice. J. Exp. Med. 129: 1079-1107.
28. Bliss, J., V. Van Cleave, K. Murray, A. Wiencis, M. Ketchum, R. Maylor, T. Haire, C. Resmini, A. K. Abbas, and S. F. Wolf. 1996. IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response. J. Immunol. 156:887-894.
29. Bodey, G. P., and E. J. Anaissie. 1989. Chronic systemic candidiasis. Eur. J. Clin. Microbiol. Infect. Dis. 8:855-857.
30. Bogdan, C., A. Gessner, W. Solbach, and M. Rollinghoff. 1996. Invasion, control and persistence of Leishmania parasites. Curr. Opin. Immunol. 8:517-525.
31. + T cells. J. Immunol. 156:1458-1468.
32. + T-cell clones: heterogeneity in antigen recognition, cytokine production, and cytotoxicity for mononuclear phagocytes. Infect. Immun. 59:2737-2743.
33. Bost, K. L., and J. D. Clements. 1995. In vivo induction of interleukin-12 mRNA expression after oral immunization with Salmonella dublin or the B subunit of Escherichia coli heat-labile enterotoxin. Infect. Immun. 63:1076-1083.
34. Brunda, M. J. 1994. Interleukin-12. J. Leukocyte Biol. 55:280-288.
35. Brunda, M. J. 1995. Role of IL12 as an anti-tumour agent: current status and future directions. Res. Immunol. 146:622-627.
36. Bullock, W. E. 1995. Histoplasma capsulatum, p. 2340-2353. In G. L. Mandell, J. E. Bennett, and R. Dolin (ed.), Principles and practices of infectious diseases, 4th ed. Churchill-Livingstone, Inc., New York, N.Y.
37. Capron, M., and A. Capron. 1994. Immunoglobulin E and effector cells in schistosomiasis. Science 264:1876-1878.
38. Cardillo, F., J. C. Voltarelli, S. G. Reed, and J. S. Silva. 1996. Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin-10: the role of NK cells. Infect. Immun. 64:128-134.
39. Carrera, L., R. T. Gazzinelli, R. Badolato, S. Hieny, W. Muller, R. Kuhn, and D. L. Sacks. 1996. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice. J. Exp. Med. 183:515-526.
40. Carter, L. L., and R. W. Dutton. 1996. Type 1 and type 2: a fundamental dichotomy for all T cell subsets. Curr. Opin. Immunol. 8:336-342.
41. Cassatella, M. A., L. Meda, S. Gasperini, S. D'Andrea, X. Ma, and G. Trinchieri. 1995. Interleukin-12 production by human polymorphonuclear leukocytes. Eur. J. Immunol. 25:1-5.
42. Cassone, A., P. Chiani, I. Quinti, and A. Torosantucci. A possible participation of polymorphonuclear cells stimulated by microbial immunomodulators in cytokine dysregulated patterns of AIDS patients. J. Leukocyte Biol., in press.
43. Castro, A. G., R. A. Silva, and R. Appelberg. 1995. Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice. J. Immunol. 155:2013-2019.
44. Cauwles, A., W. Fiers, and P. Brouckaert. 1996. Murine IL-12 is involved in Calmette Guérin bacillus-induced sensitization and is by itself sufficient to sensitize mice to the lethal effects of human TNF. J. Immunol. 156:4686-4690.
45. Cavanaugh, V. J., L. G. Guidotti, and F. V. Chisari. 1997. Interleukin-12 inhibits hepatitis B virus replication in transgenic mice. J. Virol. 71:3236-3243.
46. Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747-752.
47. Cellier, M., G. Govoni, S. Vidal, T. Kwan, N. Groulx, J. Liu, F. Sanchez, E. Skamene, E. Schurr, and P. Gros. 1994. Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. J. Exp. Med. 180:1741-1752.
48. Cellier, M., G. Prive, A. Belouchi, T. Kwan, V. Rodrigues, W. Chia, and P. Gros. 1995. Nramp defines a family of membrane proteins. Proc. Natl. Acad. Sci. USA 92:10089-10093.
49. Cenci, E., S. Perito, K.-H. Enssle, P. Mosci, J.-P. Latgé, L. Romani, and F. Bistoni. 1996. Th1 and Th2 cytokines in mice with invasive aspergillosis. Infect. Immun. 65:564-570.
50. Chan, S. H., M. Kobayashi, D. Santoli, B. Perussia, and G. Trinchieri. 1992. Mechanisms of IFN-γ induction by natural killer cell stimulatory factor (NKSF/IL-12): role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2. J. Immunol. 148:92-98.
51. Chan, S. H., B. Perussia, J. W. Gupta, M. Kobayashi, M. Pospisil, H. A. Young, S. F. Wolf, D. Young, S. C. Clark, and G. Trinchieri. 1991. Induction of IFN-γ production by NK cell stimulatory factor (NKSF): characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173:869-879.
52. Chehimi, J., C. Paganin, I. Frank, S. Chouaib, S. Starr, and G. Trinchieri. 1995. Interleukin-12 in the pathogenesis and therapy of HIV disease. Res. Immunol. 146:605-614.
53. Chehimi, J., S. Starr, I. Frank, A. D'Andrea, X. Ma, R. R. MacGregor, J. Sennelier, and G. Trinchieri. 1994. Impaired interleukin-12 production in human immunodeficiency virus-infected patients. J. Exp. Med. 179:1361-1366.
54. Chehimi, J., S. Starr, I. Frank, M. Rengaraju, S. J. Jackson, C. Lanes, M. Kobayashi, B. Perussia, D. Young, E. Nickbarg, S. F. Wolf, and G. Trinchieri. 1992. Natural killer cell stimulatory factor (NKSF) increases the cytotoxic activity of NK cells both in healthy donors and HIV-infected patients. J. Exp. Med. 175:789-796.
55. Chehimi, J., N. M. Valiante, A. D'Andrea, M. Rengaraju, Z. Rosado, M. Kobayashi, B. Perussia, S. Wolf, S. E. Starr, and G. Trinchieri. 1993. Enhancing effect of natural killer cell stimulatory factor (NKSF/IL-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells. Eur. J. Immunol. 23:1826-1830.
56. Chensue, S. W., J. H. Ruth, K. Warmington, P. Lincoln, and S. L. Kunkel. 1995. In vivo regulation of macrophage IL-12 production during type 1 and type 2 cytokine-mediated granuloma formation. J. Immunol. 155:3546-3551.
57. Chensue, S. W., P. D. Terebuh, K. S. Warmington, S. D. Hershey, H. L. Evanoff, S. L. Kunkel, and G. I. Higashi. 1992. Role of interleukin-4 and gamma-interferon in Schistosoma mansoni egg-induced hypersensitivity formation: orchestration, relative contribution and relationship to macrophage function. J. Immunol. 148:900-910.
58. Chizzonite, R., T. Truitt, M. Griffin, E. Nickbarg, B. Hubbard, B. B. Desai, A. S. Stern, U. Gubler, and M. Gately. 1993. Initial characterization of the IL-12 receptor (IL-12R) on Concanavalin-A activated mouse splenocytes. J. Cell. Biochem. 17B:73.
59. Chizzonite, R., T. Truitt, P. Nunes, B. B. Desai, A. O. Chua, M. K. Gately, and U. Gubler. 1994. High and low affinity receptors for interleukin-12 (IL-12) on human T cells: evidence for a two subunit receptor by IL-12 and anti-receptor antibody binding. Cytokine 6:A82a.
60. Chizzonite, R., T. Truitt, F. J. Podlaski, A. G. Wolitzky, P. M. Quinn, P. Nunes, A. S. Stern, and M. Gately. 1991. IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts. J. Immunol. 147:1548-1556.
61. Chong, C., K. L. Bost, and J. D. Clements. 1996. Differential production of interleukin-12 mRNA by murine macrophages in response to viable or killed Salmonella spp. Infect. Immun. 64:1154-1160.
62. Chougnet, C., M. Clerici, and G. M. Shearer. 1995. Role of IL12 in HIV disease/AIDS. Res. Immunol. 146:615-621.
63. 2 to the IL-12 defect in HIV-infected patients. AIDS 10:1043-1045.
64. Chougnet, C., T. A. Wynn, M. Clerici, A. L. Landay, H. A. Kessler, J. Rusnak, G. P. Melcher, A. Sher, and G. M. Shearer. 1996. Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus. J. Infect. Dis. 174:46-53.
65. Chua, A. O., R. Chizzonite, B. B. Desai, T. P. Truitt, P. Nunes, L. J. Minetti, R. R. Warrier, D. H. Presky, S. F. Levine, M. K. Gately, and U. Gubler. 1994. Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. J. Immunol. 153:128-136.
66. Chua, A. O., V. L. Wilkinson, D. H. Presky, and U. Gubler. 1995. Cloning and characterization of a mouse IL-12 receptor-β component. J. Immunol. 155:4286-4294.
67. Clemons, K. V., E. Brummer, and D. A. Stevens. 1994. Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis. Antimicrob. Agents Chemother. 38:460-464.
68. Clerici, M., D. R. Lucey, J. A. Berzofsky, L. A. Pinto, T. A. Wynn, S. P. Blatt, M. J. Dolan, C. W. Hendrix, S. F. Wolf, and G. M. Shearer. 1993. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 262:1721-1724.
69. Clerici, M., A. Sarin, R. L. Coffman, T. A. Wynn, S. P. Blatt, C. W. Hendrix, S. F. Wolf, G. M. Shearer, and P. A. Henkart. 1994. Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis. Proc. Natl. Acad. Sci. USA 91:11811-11815.
70. Clerici, M., and G. M. Shearer. 1993. A TH1→TH2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14:107-111.
71. Clerici, M., and G. M. Shearer. 1994. The TH1/TH2 hypothesis of HIV infection: new insights. Immunol. Today 15:575-581.
72. Clerici, M., T. A. Wynn, J. A. Berzofsky, S. P. Blatt, C. W. Hendrix, A. Sher, R. L. Coffman, and G. M. Shearer. 1994. Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J. Clin. Invest. 93:768-775.
73. Cleveland, M. G., J. D. Gorham, T. L. Murphy, E. Tuomanen, and K. M. Murphy. 1996. Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway. Infect. Immun. 64:1906-1912.
74. Coley, W. B. 1893. The treatment of malignant tumors by repeated inoculations of erysipelas with a report of ten original cases. Am. J. Med. Sci. 105:483-564.
75. Conlan, J. W., and R. J. North. 1991. Neutrophil-mediated dissolution of infected host cells as a defense strategy against a facultative intracellular bacterium. J. Exp. Med. 174:741-744.
76. + T-cell-dependent and independent host defense mechanisms can operate to control and resolve primary and secondary Francisella tularensis LVS infection in mice. Infect. Immun. 62:5603-5607.
77. Cooper, A. M., J. E. Callahan, J. P. Griffin, A. D. Roberts, and I. M. Orme. 1995. Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis. Infect. Immun. 63:3259-3265.
78. Cooper, A. M., D. K. Dalton, T. A. Stewart, J. P. Griffin, D. G. Russell, and I. M. Orme. 1993. Disseminated tuberculosis in interferon-γ gene-disrupted mice. J. Exp. Med. 178:2243-2247.
79. Cooper, A. M., A. D. Roberts, E. R. Rhoades, J. E. Callahan, D. M. Getzy, and I. M. Orme. 1995. The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection. Immunology 84:423-432.
80. Cousens, L. P., J. S. Orange, H. C. Su, and C. A. Biron. 1997. Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection. Proc. Natl. Acad. Sci. USA 94:634-639.
81. Coutelier, J. P., J. van Broeck, and S. F. Wolf. 1995. Interleukin-12 gene expression after viral infection in the mouse. J. Virol. 69:1955-1958.
82. Cox, R. A., W. Kennel, L. Boncyk, and J. W. Murphy. 1988. Induction and expression of cell-mediated immune responses in inbred mice infected with Coccidioides immitis. Infect. Immun. 56:13-17.
83. Crutcher, J. M., M. M. Stevenson, M. Sedegah, and S. L. Hoffman. 1995. Interleukin-12 and malaria. Res. Immunol. 146:552-559.
84. Daftarian, M. P., F. Diaz-Mitoma, W. D. Creery, W. Cameron, and A. Kumar. 1995. Dysregulated production of interleukin-10 (IL-10) and IL-12 by peripheral blood lymphocytes from human immunodeficiency virus-infected individuals is associated with altered proliferative responses to recall antigens. Diagn. Lab. Immunol. 2:712-718.
85. Dalton, D. K., S. Pitts-Meck, S. Keshev, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259:1739-1742.
86. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin-10 inhibits human lymphocyte IFN-γ production by suppressing natural killer cell stimulatory factor/interleukin-12 synthesis in accessory cells. J. Exp. Med. 178:1041-1048.
87. D'Andrea, A., X. Ma, M. Aste-Amezaga, C. Paganin, and G. Trinchieri. 1995. Stimulatory and inhibitory effects of IL-4 and IL-13 on production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and TNF-α production. J. Exp. Med. 181:537-546.
88. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste-Amezaga, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, R. Chizzonite, S. F. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387-1398.
89. Daugelat, S., and S. H. E. Kaufmann. 1996. Role of Th1 and Th2 cells in bacterial infections. Chem. Immunol. 63:66-97.
90. Daugelat, S., C. H. Ladel, and S. H. E. Kaufmann. 1995. Impact of host genetic background on bacillus Calmette-Guérin infection in naturally susceptible mice. Immunol. Lett. 48:153-156.
91. DeKruyff, R. H., R. S. Gieni, and D. T. Umetsu. 1997. Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40. J. Immunol. 158:359-366.
92. Denis, M. 1991. Involvement of cytokines in determining resistance and acquired immunity in murine tuberculosis. J. Leukocyte Biol. 50:495-501.
93. Denis, M. 1991. Modulation of Mycobacterium avium growth in vivo by cytokines: involvement of tumour necrosis factor in resistance to atypical mycobacteria. Clin. Exp. Immunol. 83:466-471.
94. Denis, M. 1994. Interleukin-12 (IL-12) augments cytolytic activity of natural killer cells toward Mycobacterium tuberculosis infected human monocytes. Cell. Immunol. 156:529-536.
95. Denis, M., and E. Ghadirian. 1994. Dysregulation of interleukin-8, interleukin-10, and interleukin-12 release by alveolar macrophages from HIV type 1-infected subjects. AIDS Res. Hum. Retroviruses 10:1619-1627.
96. Derrico, C. A., and K. J. Goodrum. 1996. Interleukin-12 and tumor necrosis factor alpha mediate innate production of gamma interferon by group B Streptococcus-treated splenocytes of severe combined immunodeficiency mice. Infect. Immun. 64:1314-1320.
97. Descoteaux, A., G. Maltashewski, and S. J. Turco. 1992. Inhibition of macrophage protein kinase C-mediated protein phosphorylation by Leishmania donovani lipophosphoglycan. J. Immunol. 149:3008-3015.
98. Dorig, R. E., A. Marcil, A. Chopra, and C. D. Richardson. 1993. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75:295-305.
99. s) congenic mouse strains show similar cytokine responses following infection with Salmonella dublin. J. Immunol. 156:2894-2900.
100. Ehlers, S., M. E. A. Mielke, and H. Hahn. 1994. Progress in TB research: Robert Koch's dilemma revisited. Immunol. Today 15:1-4.
101. Elkins, K. L., T. Rhinehart-Jones, C. A. Nacy, R. K. Winegar, and A. H. Fortier. 1993. T-cell-independent resistance to infection and generation of immunity to Francisella tularensis. Infect. Immun. 61:823-829.
102. Else, K., and R. Grancis. 1991. Cellular immune responses to the nematode parasite Trichuris muris. I. Differential cytokine production during acute or chronic infection. Immunology 72:508-515.
103. Emmerling, P., H. Finger, and J. Bockenmühl. 1974. Listeria monocytogenes infection in nude mice. Infect. Immun. 12:437-439.
104. intermediate liver lymphocytes are downregulated by Listeria monocytogenes. Eur. J. Immunol. 25:3321-3325.
105. s mice. J. Immunol. 150:3411-3420.
106. Eng, V. M., B. D. Car, B. Schnyder, M. Lorenz, S. Lugli, M. Aguet, T. D. Anderson, B. Ryffel, and V. F. J. Quesniaux. 1995. The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo. J. Exp. Med. 181:1893-1898.
107. + T cells from human immunodeficiency virus-infected persons. J. Exp. Med. 182:1759-1767.
108. Fantuzzi, L., S. Gessani, P. Borghi, B. Varano, L. Conti, P. Puddu, and F. Belardelli. 1996. Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion. J. Virol. 70:4121-4124.
109. Fearon, D. T., and R. M. Locksley. 1996. The instructive role of innate immunity in the acquired immune response. Science 272:50-54.
110. Fernandes, D. M., and C. L. Baldwin. 1995. Interleukin-10 downregulates protective immunity to Brucella abortus. Infect. Immun. 63:1130-1133.
111. Ferrieri, P. 1990. Neonatal susceptibility and immunity to major bacterial pathogens. Rev. Infect. Dis. 12:5394-5400.
112. Filgueira, L., F. O. Nestlé, M. Rittig, H. I. Joller, and P. Groscurth. 1996. Human dendritic cells phagocytose and process Borrelia burgdorferi. J. Immunol. 157:2998-3005.
113. Finkelman, F. D., K. Madden, A. Cheever, I. M. Katona, S. C. Morris, M. Gately, B. R. Hubbard, W. C. Gause, and J. Urban. 1994. Effects of interleukin-12 on immune responses and host protection in mice infected with intestinal nematode parasites. J. Exp. Med. 179:1563-1572.
114. Flesch, I. E. A., J. H. Hess, S. Huang, M. Aguet, J. Rothe, H. Bluethmann, and S. H. E. Kaufmann. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α J. Exp. Med. 181:1615-1621.
115. Flesch, I., and S. H. E. Kaufmann. 1987. Mycobacterial growth inhibition by interferon-γ-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis. J. Immunol. 138:4406-4413.
116. Flesch, I. E. A., and S. H. E. Kaufmann. 1990. Stimulation of antibacterial macrophage activities by B-cell stimulatory factor 2 (interleukin-6). Infect. Immun. 58:269-271.
117. Flesch, I. E. A., and S. H. E. Kaufmann. 1990. Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor. Infect. Immun. 58:2675-2677.
118. Flesch, I. E. A., and S. H. E. Kaufmann. 1995. Differential induction of IL12 synthesis by Mycobacterium bovis BCG and Listeria monocytogenes. Res. Immunol. 146:520-525.
119. Flynn, J. L., J. Chan, K. J. Triebold, D. K. Dalton, T. A. Stewart, and B. R. Bloom. 1993. An essential role for interferon γ in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249-2254.
120. Flynn, J. L., M. M. Goldstein, K. J. Triebold, J. Sypek, S. Wolf, and B. R. Bloom. 1995. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J. Immunol. 155:2515-2524.
121. Fortier, A. H., T. Polsinelli, S. J. Green, and C. A. Nacy. 1992. Activation of macrophages for destruction of Francisella tularensis: identification of cytokines, effector cells and effector molecules. Infect. Immun. 60:817-825.
122. Fowell, D. J., A. E. Wakil, and R. M. Locksley. 1995. Interleukin-12 in murine leishmaniasis - match, flame or fuel? Res. Immunol. 146:566-574.
123. Freund, J., J. Casals, and E. P. Hosmer. 1937. Sensitization and antibody formation after injection of tubercle bacilli and paraffin oil. Proc. Soc. Exp. Biol. Med. 37:509-513.
124. Frucht, D. M., and S. M. Holland. 1996. Defective monocyte costimulation for IFN-γ production in familial disseminated Mycobacterium avium complex infection: abnormal IL-12 regulation. J. Immunol. 157:411-416.
125. Fulton, S. A., J. M. Johnsen, S. F. Wolf, D. S. Sieburth, and W. H. Boom. 1996. Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis. Infect. Immun. 64:2523-2531.
126. Gately, M. K. 1997. Interleukin-12: potential clinical applications in the treatment of chronic viral hepatitis. J. Viral Hepatol. 4(Suppl. 1):33-39.
127. Gately, M. K., R. R. Warrier, S. Honosoge, D. M. Carvajal, D. A. Faherty, S. E. Connaughton, T. D. Anderson, U. Sarmiento, B. R. Hubbard, and M. Murphy. 1994. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo. Int. Immunol. 6:157-167.
128. Gavett, S. H., D. J. O'Hearn, X. Li, S. K. Huang, F. D. Finkelman, and M. Wills-Karp. 1995. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J. Exp. Med. 182:1527-1536.
129. Gazzinelli, R. T. 1996. Molecular and cellular basis of interleukin 12 activity in prophylaxis and therapy against infectious diseases. Mol. Med. Today June:258-267.
130. Gazzinelli, R. T., S. Bala, R. Stevens, M. Baselar, L. Wahl, J. Kovaks, and A. Sher. 1995. HIV infection suppresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokines. J. Immunol. 155:1565-1574.
131. Gazzinelli, R. T., E. Y. Denkers, and A. Sher. 1993. Host resistance to Toxoplasma gondii: model for studying the selective induction of cell-mediated immunity by intracellular parasites. Infect. Agents Dis. 2:139-149.
132. Gazzinelli, R. T., N. A. Giese, and H. C. Morse III. 1994. In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS). J. Exp. Med. 180:2199-2208.
133. Gazzinelli, R. T., S. Hieny, T. Wynn, S. Wolf, and A. Sher. 1993. IL-12 is required for T-cell independent induction of IFN-γ by an intracellular parasite and induces resistance in T-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115-6119.
134. + subset regulation in viral infection: preferential activation of Th2 cells during progression of retrovirus-induced immunodeficiency in mice. J. Immunol. 148:182-188.
135. Gazzinelli, R. T., M. Wysocka, S. Hayashi, E. Y. Denkers, S. Hieny, P. Caspar, G. Trinchieri, and A. Sher. 1994. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153:2533-2543.
136. Gearing, D. P., and D. Cosman. 1991. Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell 66:9-10.
137. Gemmell, E., and G. J. Seymour. 1994. Modulation of immune responses to periodontal bacteria. Curr. Opin. Periodontol. 2:28-38.
138. Germann, T., M. Bongartz, H. Dlugonska, H. Hess, E. Schmitt, L. Kolbe, E. Kölsch, F. J. Podlaski, M. K. Gately, and E. Rüde. 1995. IL-12 profoundly upregulates the synthesis of antigen-specific, complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo. Eur. J. Immunol. 25:823-829.
139. Germann, T., S. Guckes, M. Bongartz, H. Dlugonska, E. Schmitt, L. Kolbe, E. Kölsch, F. J. Podlaski, M. K. Gately, and E. Rüde. 1995. Administration of interleukin-12 during ongoing immune responses fails to permanently suppress and can even enhance the synthesis of antigen-specific IgE. Int. Immunol. 7:1649-1657.
140. Germann, T., E. Rüde, F. Mattner, and M. K. Gately. 1995. The IL-12 p40 homodimer as a specific antagonist of the IL-12 heterodimer. Immunol. Today 16:500-501.
141. Germann, T., E. Rüde, and E. Schmitt. 1995. The influence of IL12 on the development of Th1 and Th2 cells and its adjuvant effect for humoral immune responses. Res. Immunol. 146:481-485.
142. Gerosa, F., C. Paganin, D. Peritt, F. Paiola, M. T. Scupoli, M. Aste-Amezaga, I. Frank, and G. Trinchieri. 1996. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-γ and interleukin-10. J. Exp. Med. 183:2559-2569.
143. Ghalib, H. W., J. A. Whittle, M. Kubin, F. A. Hashim, A. M. el-Hassan, K. H. Grabstein, G. Trinchieri, and S. G. Reed. 1995. IL-12 enhances Th1-type responses in human Leishmania donovani infections. J. Immunol. 154:4623-4629.
144. Giese, N. A., R. T. Gazzinelli, R. A. Morawetz, and H. C. Morse III. 1995. Role of IL12 in MAIDS. Res. Immunol. 146:600-604.
145. Gillessen, S., D. Carvajal, P. Ling, F. J. Podlaski, D. L. Stremlo, P. C. Familletti, U. Gubler, D. H. Presky, A. S. Stern, and M. K. Gately. 1995. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 25:200-206.
146. Golovliov, I., G. Sandström, M. Ericsson, A. Sjöstedt, and A. Tärnvik. 1995. Cytokine expression in the liver during the early phase of murine tularemia. Infect. Immun. 63:534-538.
147. Greenberger, M. J., S. L. Kunkel, K. M. Strieter, N. W. Lukacs, J. Bramson, J. Gauldie, F. L. Graham, M. Hitt, J. M. Danforth, and T. J. Standiford. 1996. IL-12 gene therapy protects mice in lethal Klebsiella pneumonia. J. Immunol. 157:3006-3012.
148. Greenberger, M. J., R. M. Strieter, S. L. Kunkel, J. M. Danforth, R. E. Goodman, and T. J. Standiford. 1995. Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia. J. Immunol. 155:722-729.
149. Greenberger, M. J., R. M. Strieter, S. L. Kunkel, J. M. Danforth, L. L. Laichalk, D. C. McGillicuddy, and T. J. Standiford. 1996. Neutralization of MIP-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumoniae. J. Infect. Dis. 173:159-165.
150. Grewall, I. S., J. Xu, and R. A. Flavell. 1995. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature 378:617-620.
151. Griffin, D. E., and B. J. Ward. 1993. Differential CD4 T cell activation in measles. J. Infect. Dis. 168:275-281.
152. Grzych, J. M., E. J. Pearce, A. Cheever, Z. A. Caulada, P. Caspar, S. Heiny, F. Lewis, and A. Sher. 1991. Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J. Immunol. 146:1322-1330.
153. Gubler, U., A. O. Chua, D. S. Schoenhaut, C. M. Dwyer, W. McComas, R. Motyka, N. Nabavi, A. G. Wolitzky, P. M. Quinn, P. C. Familletti, and M. K. Gately. 1991. Coexpression of two distinct genes is required to generate secreted, bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 88:4143-4147.
154. Gueler, M. L., J. D. Gorham, C. S. Hsieh, A. J. Mackey, R. G. Steen, W. F. Dietrich, and K. M. Murphy. 1996. Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development. Science 271:912-913.
155. Haak-Frendscho, M., J. F. Brown, V. Ilzawa, R. D. Wagner, and C. J. Czuprynski. 1992. Administration of anti-IL-4 antibody 11B11 increases the resistance of mice to Listeria monocytogenes infection. J. Immunol. 148:3978-3985.
156. Hahn, H., and S. H. E. Kaufmann. 1981. The role of cell-mediated immunity in bacterial infections. Rev. Infect. Dis. 3:1221-1250.
157. Halpern, M. D., R. J. Kurlander, and D. S. Pisetsky. 1996. Bacterial DNA
158. Harrison, T. S., and S. M. Levitz. 1996. Role of IL-12 in peripheral blood mononuclear cell responses to fungi in persons with and without HIV infection. J. Immunol. 156:4492-4497.
159. Harrison, T. S., and S. M. Levitz. 1997. Priming with IFN-γ restores deficient IL-12 production by peripheral blood mononuclear cells from HIV-seropositive donors. J. Immunol. 158:459-463.
160. Harty, T. J., L. L. Lenz, and M. J. Bevan. 1996. Primary and secondary immune responses to Listeria monocytogenes. Curr. Opin. Immunol. 8:526-530.
161. Hayes, M. P., J. Wang, and M. A. Norcross. 1995. Regulation of interleukin-12 expression in human monocytes: selective priming by IFN-γ of LPS-inducible p35 and p40 genes. Blood 86:646-650.
162. Heinzel, F. P. 1995. Th1 and Th2 cells in the cure and pathogenesis of infectious diseases. Curr. Opin. Infect. Dis. 8:151-155.
163. Heinzel, F. P., F. Ahmed, A. M. Hujer, and R. M. Rerko. 1995. Immunoregulation of murine leishmaniasis by interleukin-12. Res. Immunol. 146: 575-581.
164. Heinzel, F. P., R. M. Rerko, F. Ahmed, and E. Pearlman. 1995. Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice. J. Immunol. 155:730-739.
165. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505-1509.
166. Hendricks, R. L., T. M. Tumpey, and A. Finnegan. 1992. IFN-γ and IL-2 are protective in the skin but pathologic in the corneas of HSV-1 infected mice. J. Immunol. 149:3023-3028.
167. Hilleman, M. R. 1994. Vaccinology, immunology, and comparative pathogenesis of measles in the quest for a preventative against AIDS. AIDS Res. Hum. Retroviruses 10:3-12.
168. Hoag, K. A., N. E. Street, G. B. Huffnagle, and M. F. Lipscomb. 1995. Early cytokine production in pulmonary Cryptococcus neoformans infections distinguishes susceptible and resistant mice. Am. J. Respir. Cell Mol. Biol. 13:487-495.
169. Hoffman, S. L., J. M. Crutcher, S. K. Puri, A. A. Ansari, F. Villinger, E. D. Franke, P. P. Singh, F. Finkelman, M. K. Gately, G. P. Dutta, and M. Sedegah. 1997. Sterile protection of monkeys against malaria after administration of interleukin-12. Nat. Med. 3:80-83.
170. Hoffman, S. L., D. Isenbarger, G. W. Long, M. Sedegah, A. Szarfman, L. Waters, M. R. Hollingdale, P. H. van der Meide, D. S. Finbloom, and W. R. Ballou. 1989. Sporozite vaccine induces genetically restricted T cell elimination of malaria from hepatocytes. Science 244:1078-1081.
171. Hondowicz, B., and P. Scott. 1995. The role of IL12 in modulating an established Th2 response in experimental leishmaniasis. Res. Immunol. 146:560-565.
172. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547-549.
173. Hunter, C. A., L. Bermudez, H. Beernink, W. Waegell, and J. S. Remington. 1995. Transforming growth factor-β inhibits interleukin-12-induced production of interferon-γ by natural killer cells: a role for transforming growth factor-β in the regulation of T cell-independent resistance to Toxoplasma gondii. Eur. J. Immunol. 25:994-1000.
174. Hunter, C. A., E. Candolfi, C. Subauste, V. Van Cleave, and J. S. Remington. 1995. Studies on the role of interleukin-12 in acute murine toxoplasmosis. Immunology 84:16-20.
175. Hunter, C. A., R. Chizzonite, and J. S. Remington. 1995. IL-1β is required for IL-12 to induce production of IFN-γ by NK cells. A role for IL-1β in the T cell-independent mechanism of resistance against intracellular pathogens. J. Immunol. 155:4347-4354.
176. Hunter, C. A., and J. S. Remington. 1995. The role of IL12 in toxoplasmosis. Res. Immunol. 146:546-551.
177. Hunter, C. A., T. Slider, and F. Araujo. 1996. Interleukin-12-mediated resistance to Tiypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon. Infect. Immun. 64:2381-2386.
178. Hunter, C. A., C. S. Subauste, V. H. Van Cleave, and J. S. Remington. 1994. Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12 and tumor necrosis factor alpha. Infect. Immun. 62:2818-2824.
179. Huygen, K., D. Abramowicz, P. Vandenbussche, F. Jacobs, J. De Bruyn, A. Kentos, A. Drowart, J. P. van Vooren, and M. Goldman. 1992. Spleen cell cytokine secretion in Mycobacterium bovis BCG-infected mice. Infect. Immun. 60:2880-2886.
180. Hyjek, E., H. W. Lischner, T. Hyslop, J. Bartkowiak, M. Kubin, G. Trinchieri, and D. Kozbor. 1995. Cytokine patterns during progression to AIDS in children with perinatal HIV infection. J. Immunol. 155:4060-4071.
181. + T cells. J. Exp. Med. 176:581-586.
182. Jackson, J. D., Y. Yan, M. J. Brunda, L. S. Kelsey, and J. E. Talmadge. 1995. Interleukin-12 enhances peripheral hematopoiesis in vivo. Blood 85: 2371-2376.
183. Jacobsen, S. E. 1995. IL12, a direct stimulator and indirect inhibitor of haematopoiesis. Res. Immunol. 146:506-514.
184. Jacobson, N. G., S. J. Szabo, M. L. Güler, J. D. Gorham, and K. M. Murphy. 1995. Regulation of interleukin-12 signal transduction during T helper phenotype development. Res. Immunol. 146:446-456.
185. Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, and K. M. Murphy. 1995. Interleukin 12 signalling in Th1 cells involves tyrosine phosphorylation of Stat3 and Stat4. J. Exp. Med. 181:1755-1762.
186. Jahiel, R. I., J. Vilcek, and R. S. Nussenzweig. 1970. Exogenous interferon protects mice against Plasmodium berghei malaria. Nature 227:1350.
187. Jahiel, R. I., J. Vilcek, R. S. Nussenzweig, and J. Vanderberg. 1968. Interferon inducers protect mice against Plasmodium berghei malaria. Science 161:802-804.
188. James, S. L., and D. L. Boros. 1994. Immune effector role of macrophages in experimental Schistosoma mansoni. Immunol. Ser. 60:461-466.
189. + T-cell function in host-parasite models. Chem. Immunol. 63:51-65.
190. Jeannin, P., Y. Delneste, P. Life, J.-F. Gauchat, D. Kaiserlian, and J.-Y. Bonnefoy. 1995. Interleukin-12 increases interleukin-4 production by established human Th0 and Th2-like T cell clones. Eur. J. Immunol. 25:2247-2252.
191. Jiang, X., and C. L. Baldwin. 1993. Effects of cytokines on intracellular growth of Brucella abortus. Infect. Immun. 61:124-129.
192. Jones, S. M., and A. J. Winter. 1992. Survival of virulent and attenuated strains of Brucella abortus in normal and gamma interferon-activated murine peritoneal macrophages. Infect. Immun. 60:3011-3014.
193. Kagaya, K., K. Watanabe, and Y. Fukazawa. 1989. Capacity of recombinant gamma interferon to activate macrophages for Salmonella-killing activity. Infect. Immun. 57:609-615.
194. Kamijo, R., J. Le, D. Shapiro, E. A. Havell, S. Huang, M. Aguet, M. Bosland, and J. Vilcek. 1993. Mice that lack the interferon-γ receptor have profoundly altered responses to infection with bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide. J. Exp. Med. 178:1435-1440.
195. Kanangat, S., J. Thomas, S. Gangappa, J. S. Babu, and B. T. Rouse. 1996. Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. J. Immunol. 156:1110-1116.
196. Kaplan, M. H., Y.-L. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174-177.
197. Karp, C. L., M. Wysocka, L. M. Wahl, J. M. Ahearn, P. J. Cuomo, B. Sherry, G. Trinchieri, and D. E. Griffin. 1996. Mechanism of suppression of cell-mediated immunity by measles virus. Science 273:228-231.
198. Karttunen, R., T. J. Karttunen, M. M. Yousfi, H. M. el-Zimaity, D. Y. Graham, and F. A. el-Zaatari. 1997. Expression of mRNA for interferon-γ, interleukin-10, and interleukin-12 (p40) in normal gastric mucosa and in mucosa infected with Helicobacter pylori. Scand. J. Gastroenterol. 32:22-27.
199. Karttunen, R., H. M. Surcel, G. Andersson, H. P. T. Ekre, and E. Herva. 1991. Francisella tularenesis-induced in vitro gamma-interferon, tumor necrosis factor α, and interleukin-2 responses appear within 2 weeks of tularemia vaccination in human beings. J. Clin. Microbiol. 29:753-756.
200. Kato, T., R. Hakamada, H. Yamane, and H. Nariuchi. 1996. Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction. J. Immunol. 156:3932-3938.
201. Kaufmann, S. H. E. 1993. Immunity to intracellular bacteria. Annu. Rev. Immunol. 11:129-163.
202. + T-cell clones from Mycobacterium tuberculosis-immune mice. Infect. Immun. 54:291-296.
203. Kaufmann, S. H. E., E. Hug, and G. DeLibero. 1986. Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells. J. Exp. Med. 164:363-368.
204. Kawakami, K., M. Tohyama, Q. Xie, and A. Saito. 1996. IL-12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans. Clin. Exp. Immunol. 104:208-214.
205. Kawamura, I., H. Tsukada, H. Yoshikawa, M. Fujita, K. Nomoto, and M. Mitsuyama. 1992. IFN-γ-producing ability as a possible marker for the protective T cells against Mycobacterium bovis BCG in mice. J. Immunol. 148:2997-2893.
206. Keane-Myers, A., and S. P. Nickell. 1995. T-cell subset-dependent modulation of immunity to Borrelia burgdorferi in mice. J. Immunol. 154:1770-1776.
207. Keane-Myers, A., and S. P. Nickell. 1995. Role of IL-4 and IFN-γ in modulation of immunity to Borrelia burgdorferi in mice. J. Immunol. 155: 2020-2028.
208. Kennedy, M. K., K. S. Picha, W. C. Fanslow, K. H. Grabstein, M. R. Alderson, K. N. Clifford, W. A. Chin, and K. A. Mohler. 1996. CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages. Eur. J. Immunol. 26:370-378.
209. Khan, I. A., T. Matsuura, and L. H. Kasper. 1994. Interleukin-12 enhances murine survival against acute toxoplasmosis. Infect. Immun. 62:1639-1642.
210. Kim, J. J., V. Ayyavoo, M. L. Bagarazzi, M. A. Chattergoon, K. Dang, B. Wang, J. D. Boyer, and D. B. Weiner. 1997. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J. Immunol. 158:816-826.
211. Kincy-Cain, T., J. D. Clements, and K. L. Bost. 1996. Endogenous and exogenous interleukin-12 augment the protective immune response in mice orally challenged with Salmonella dublin. Infect. Immun. 64:1437-1440.
212. King, C. L., J. Hakimi, M. T. Shata, and T. Medhat. 1995. IL-12 regulation of parasite antigen-driven IgE production in human helminth infections. J. Immunol. 155:454-461.
213. Kipps, T. J. 1989. The CD5 B cell. Adv. Immunol. 47:117-186.
214. Klapproth, J.-M., M. S. Donnenberg, J. M. Abraham, H. L. T. Mobley, and S. P. James. 1995. Products of enteropathogenic Escherichia coli inhibit lymphocyte activation and lymphokine production. Infect. Immun. 63:2248-2254.
215. Klinman, D. M., A. K. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. USA 93:2879-2883.
216. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. London, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827-846.
217. Kobayashi, K., T. Kasama, J. Yamazaki, M. Hosaka, T. Katsura, T. Mochizuki, K. Soejima, and R. M. Nakamura. 1995. Protection of mice from Mycobacterium avium infection by recombinant interleukin-12. Antimicrob. Agents Chemother. 39:1369-1371.
218. Kobayashi, K., J. Yamazaki, T. Kasama, T. Katsura, K. Kasahara, S. F. Wolf, and T. Shimamura. 1996. Interleukin (IL)-12 deficiency in susceptible mice infected with Mycobacterium avium and amelioration of established infection by IL-12 replacement therapy. J. Infect. Dis. 174:564-573.
219. Koch, F., U. Stanzl, P. Jannewein, K. Janke, C. Heufler, E. Kampgen, N. Romani, and G. Schuler. 1996. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184:741-746.
220. Kohno, K., J. Kataoka, T. Ohtsuki, Y. Suemoto, I. Okamoto, M. Usui, M. Ikeda, and M. Kurimoto. 1997. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J. Immunol. 158:1541-1550.
221. Kornelisse, R. F., C. E. Hack, H. F. J. Savelkoul, T. C. T. M. van der Pouw Kraan, W. C. J. Hop, G. van Mierlo, M. H. Suur, H. J. Neijens, and R. de Groot. 1997. Intrathecal production of interleukin-12 and gamma interferon in patients with bacterial meningitis. Infect. Immun. 65:877-881.
222. Kozel, T. R. 1993. Cryptococcosis, p. 277-302. In J. W. Murphy, H. Friedman, and M. Bendinelli (ed.), Fungal infection and immune response. Plenum Press, New York, N.Y.
223. Kubin, M., J. M. Chow, and G. Trinchieri. 1994. Differential regulation of interleukin-12 (IL-12), tumor necrosis factor-α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood 83:1847-1855.
224. Kubin, M., M. Kamoun, and G. Trinchieri. 1994. Interleukin-12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180:211-222.
225. Kumaratilake, L. M., and A. Ferrante. 1994. T-cell cytokines in malaria: their role in the regulation of neutrophil and macrophage-mediated killing of Plasmodium falciparum asexual blood forms. Res. Immunol. 145:423-429.
226. Kurup, V. P., V. Hari, I. Guo, P. J. Murali, A. Resnick, M. Krishnan, and I. N. Fink. 1996. Aspergillus fumigatus peptides differentially express Th1 and Th2 cytokines. Peptides 17:183-190.
227. Kurup, V. P., B. W. P. Seymour, H. Choi, and R. L. Coffman. 1994. Particulate Aspergillus fumigatus antigens elicit a Th2-response in BALB/c mice. J. Allergy Clin. Immunol. 93:1013-1020.
228. Ladel, C. H., J. Hess, S. Daugelat, and S. H. E. Kaufmann. 1995. Contribution of α/β and γ/δ T lymphocytes to immunity against Mycobacterium bovis BCG infection: studies with T cell receptor deficient knockout mice. Eur. J. Immunol. 25:838-846.
229. Lagrange, P. H., and G. B. Mackaness. 1975. A stable form of delayed-type hypersensitivity. J. Exp. Med. 141:82-96.
230. Lahesmaa, R., H. Yssel, S. Batsford, R. Luukkainen, T. Möttönen, L. Steinman, and G. Petz. 1992. Yersinia enterocolitica activates a T helper type 1-like T cell subset in reactive arthritis. J. Immunol. 148:3079-3085.
231. Landay, A. L., M. Clerici, F. Hashemi, H. Kassler, J. A. Berzofsky, and G. M. Shearer. 1996. In vitro restoration of T cell immune function in human immunodeficiency virus-positive persons: effects of interleukin (IL)-12 and anti-IL-10. J. Infect. Dis. 173:1085-1091.
232. Langhorne, J., S. Gillard, B. Simon, S. Slade, and K. Eichmann. 1989. Frequencies of CD4+ T cells reactive with Plasmodium chabaudi: distinct response kinetics for cells with Th1 and Th2 characteristics during infection. Int. Immunol. 1:416-424.
233. -. Eur. J. Immunol. 25:3298-3307.
234. Leiby, D. A., A. H. Fortier, R. M. Crawford, R. D. Schreiber, and C. A. Nacy. 1992. In vivo modulation of the murine immune response to Francisella tularensis LVS by administration of anticytokine antibodies. Infect. Immun. 60:84-89.
235. Leiby, D. A., R. D. Schreiber, and C. A. Nacy. 1993. IFN-γ produced in vivo during the first two days is critical for resolution of murine Leishmania major infections. Microb. Pathog. 14:495-500.
236. Lester, M. R., M. F. Hofer, M. Gately, A. Trumble, and D. Y. M. Leung. 1995. Down-regulating effects of IL-4 and IL-10 on the IFN-γ response in atopic dermatitis. J. Immunol. 154:6174-6181.
237. Leung, D. Y. M., M. Gately, A. Trumble, B. Ferguson-Darnell, P. M. Schlievert, and L. J. Picker. 1995. Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J. Exp. Med. 181:747-753.
238. Libraty, D. H., L. E. Airan, K. Uyemura, D. Jullien, B. Spellberg, T. H. Rea, and R. L. Modlin. 1997. Interferon-γ differentially regulates interleukin-12 and interleukin-10 production in leprosy. J. Clin. Invest. 99:336-341.
239. Lin, Y., M. Zhang, F. M. Hofman, J. Gong, and P. F. Barnes. 1996. Absence of a prominent Th2 cytokine response in human tuberculosis. Infect. Immun. 64:1351-1356.
240. Lindblad, E. B., M. J. Elhay, R. Silva, R. Appelberg, and P. Andersen. 1997. Adjuvant modulation of immune responses to tuberculosis subunit vaccines. Infect. Immun. 65:623-629.
241. Liu, W., and R. J. Kurlander. 1995. Analysis of the interrelationship between IL-12, TNF-α, and IFN-γ production during murine listeriosis. Cell. Immunol. 163:260-267.
242. Locksley, R. M. 1993. Interleukin 12 in host defense against microbial pathogens. Proc. Natl. Acad. Sci. USA 90:5879-5880.
243. Locksley, R. M. 1994. Th2 cells: help for helminths. J. Exp. Med. 179:1405-1407.
244. Locksley, R. M., and P. Scott. 1991. Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunol. Today 12: A58-A61.
245. Locksley, R. M., and C. B. Wilson. 1995. Cell-mediated immunity and its role in host defense, p. 102-149. In G. L. Mandell, J. E. Bennett, and R. Dolin (ed.), Basic principles in the diagnosis and management of infectious diseases, 4th ed. Churchill Livingstone, Inc., New York, N.Y.
246. Lucey, D. R., M. Clerici, and G. M. Shearer. 1996. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin. Microbiol. Rev. 9:532-562.
247. Lucey, D. R., and J. H. Maguire. 1993. Schistosomiasis. Infect. Dis. Clin. North Am. 7:635-655.
248. Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by IFN-γ in monocytic cells. J. Exp. Med. 183:147-157.
249. Ma, X., A. D'Andrea, M. Kubin, M. Aste-Amezaga, A. Sartori, J. Monteiro, L. Showe, M. Wysocka, and G. Trinchieri. 1995. Production of interleukin-12. Res. Immunol. 146:432-438.
250. Ma, Y., K. P. Seiler, K.-F. Tai, L. Yang, and M. Woods. 1994. Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide production by the cytokine-inducible pathway. Infect. Immun. 62:3663-3671.
251. + T cells. J. Immunol. 154:5071-5079.
252. Mackaness, G. B., and W. C. Hill. 1969. The effect of anti-lymphocyte globulin on cell-mediated resistance to infection. J. Exp. Med. 129:993-1012.
253. Magee, D. M., and R. A. Cox. 1995. Roles of gamma interferon and interleukin-4 in genetically determined resistance to Coccidioides immitis. Infect. Immun. 63:3514-3519.
254. Magee, D. M., and R. A. Cox. 1996. Interleukin-12 regulation of host defenses against Coccidioides immitis. Infect. Immun. 64:3609-3613.
255. Maggi, E., M. Mazzetti, A. Ravina, F. Annunziato, M. De Carli, M. P. Piccinni, R. Manetti, M. Carbonari, A. M. Pesce, G. Del Prete, and S. Romagnani. 1994. Ability of HIV to promote a Th1 to Th0 shift and to replicate preferentially in Th2 and Th0 cells. Science 265:244-248.
256. Magram, J., S. E. Connaughton, R. R. Warner, D. M. Carvajal, C. Y. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 4:471-481.
257. Mahon, B. P., M. S. Ryan, F. Griffin, and K. H. Mills. 1996. Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting induction of Th1. Infect. Immun. 64:5295-5301.
258. Manetti, R., F. Annunziato, V. Giannò, L. Tomasévic, L. Beloni, C. Mavilia, and E. Maggi. 1996. Th1 and Th2 cells in HIV infection. Chem. Immunol. 63:138-157.
259. Manetti, R., F. Gerosa, M.-G. Giudizi, R. Biagiotti, P. Parronchi, M.-P. Piccinni, S. Sampognaro, E. Maggi, S. Romagnani, and G. Trinchieri. 1994. Interleukin-12 induces stable priming for interferon-γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J. Exp. Med. 179:1273-1283.
260. Manetti, R., P. Parronchi, M. G. Giudizi, R. Biagiotti, M.-P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (NKSF/IL-12) induces Th1-type specific immune responses and inhibits the development of IL-4 producing Th cells. J. Exp. Med. 177:1199-1204.
261. Maruyama, T., A. McLachlan, S. Iino, K. Koike, K. Kurokawa, and D. R. Milich. 1993. The serology of chronic hepatitis B infection revisited. J. Clin. Invest. 91:2586-2595.
262. Mastroeni, P., J. A. Harrison, J. A. Chabalgoity, and C. E. Hormaeche. 1996. Effect of interleukin 12 neutralization on host resistance and gamma interferon production in mouse typhoid. Infect. Immun. 64:189-196.
263. Matsuo, R., M. Kobayashi, D. N. Herndon, R. B. Pollard, and F. Suzuki. 1996. Interleukin-12 protects thermally injured mice from herpes simplex virus type 1 infection. J. Leukocyte Biol. 59:623-630.
264. Mattner, F., S. Fischer, S. Guckes, S. Jin, H. Kaulen, E. Schmitt, E. Rüde, and T. Germann. 1993. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 23:2202-2208.
265. Mattner, F., J. Magram, J. Ferrante, P. Launois, K. Di Padova, R. Behin, M. K. Gately, J. A. Louis, and G. Alber. 1996. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur. J. Immunol. 26:1553-1559.
266. Matyniak, J. E., and S. L. Reiner. 1995. T helper phenotype and genetic susceptibility in experimental Lyme disease. J. Exp. Med. 181:1251-1254.
267. + T cell counts have impaired Th1 responses. J. Immunol. 158:492-500.
268. + T-helper-cell responses in mice with low-level Candida albicans infection. Infect. Immun. 64:4907-4914.
269. Merberg, D. M., S. F. Wolf, and S. C. Clark. 1992. Sequence similarity between NKSF and the IL-6/G-CSF family. Immunol. Today 13:77-78.
270. Metzger, D. W., R. Raeder, V. H. van Cleave, and M. D. Boyle. 1995. Protection of mice from group A streptococcal skin infection by interleukin-12. J. Infect. Dis. 171:1643-1645.
271. Metzger, D. W., L. A. Vogel, V. H. van Cleave, T. L. Lester, and J. M. Buchanan. 1995. The effects of IL12 on B-cell subset function. Res. Immunol. 146:499-505.
272. 2 production. Blood 89:570-576.
273. Mielke, M. E. A. 1991. T cell subsets in granulomatous inflammation and immunity to L. monocytogenes and B. abortus. Behring Inst. Mitt. 88:99-111.
274. Milich, D. R., S. F. Wolf, J. L. Hughes, and J. E. Jones. 1995. Interleukin 12 suppresses autoantibody production by reversing helper T-cell phenotype in hepatitis B antigen transgenic mice. Proc. Natl. Acad. Sci. USA 92:6847-6851.
275. Miller, M. A., M. J. Skeen, and H. K. Ziegler. 1995. Nonviable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes. J. Immunol. 155: 4817-4828.
276. Modlin, R. L. 1994. Th1-Th2 paradigm: insights from leprosy. J. Invest. Dermatol. 102:828-832.
277. Modlin, R. L., and P. F. Barnes. 1995. IL12 and the human immune response to mycobacteria. Res. Immunol. 146:526-531.
278. Moore, K. J., S. Lebrecque, and G. Matlashewski. 1993. Alteration of Leishmania donovani infection levels by selective impairment of macrophage signal transduction. J. Immunol. 150:4457-4465.
279. Morris, S. C., K. B. Madden, J. J. Adamovicz, W. C. Gause, B. R. Hubbard, M. K. Gately, and F. D. Finkelman. 1994. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J. Immunol. 152:1047-1056.
280. Morrissey, P. J., and K. Charrier. 1990. GM-CSF administration augments the survival of Ity-resistant A/J mice, but not Ity-susceptible C57BL/6 mice, to a lethal challenge with Salmonella typhimurium. J. Immunol. 144:557-561.
281. Morrissey, P. J., and K. Charrier. 1994. Treatment of mice with IL-1 before infection increases resistance to a lethal challenge with Salmonella typhimurium: the effect correlates with the resistance allele at the Ity locus. J. Immunol. 153:212-219.
282. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348-2357.
283. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
284. Mougneau, E., F. Altare, A. E. Wakil, S. Zheng, T. Coppolla, Z.-E. Wang, R. Waldmann, R. M. Locksley, and N. Glaichenhaus. 1995. Expression cloning of a protective Leishmania antigen. Science 268:563-566.
285. Mountford, A. P., S. Anderson, and R. A. Wilson. 1996. Induction of Th1 cell-mediated protective immunity to Schistosoma mansoni by coadministration of larval antigens and IL-12 as an adjuvant. J. Immunol. 156:4739-4745.
286. Muller, G., J. Saloga, T. Germann, I. Bellinghausen, and M. Mohamadzadeh. 1994. Identification and induction of human keratinocyte-derived IL-12. J. Clin. Invest. 94:1799-1805.
287. Munk, M. E., and M. Emoto. 1995. Functions of T-cell subsets and cytokines in mycobacterial infections. Eur. Respir. J. 20(Suppl. P):668-675s.
288. Munk, M. E., P. Mayer, P. Anding, K. Feldmann, and S. H. E. Kaufmann. 1996. Increased numbers of interleukin-12-producing cells in human tuberculosis. Infect. Immun. 64:1078-1080.
289. Muotiala, A., and P. H. Makela. 1990. The role of IFN-γ in murine Salmonella typhimurium infection. Microb. Pathog. 8:135-141.
290. Murphy, T. L., M. G. Cleveland, P. Kulesza, J. Magram, and K. M. Murphy. 1995. Regulation of interleukin 12 p40 expression through an NF-κB half-site. Mol. Cell. Biol. 15:5258-5267.
291. Murphy, E. E., G. Terres, S. E. Macatonia, C. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G. Trinchieri, K. Murphy, and A. O'Garra. 1994. B7 and IL-12 cooperate for proliferation and IFN-γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223-231.
292. Murray, H. W., and J. Hariprashad. 1995. Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis. J. Exp. Med. 181:387-391.
293. Murray, H. W., J. Hariprashad, D. F. McDermott, and M. Y. Stoeckle. 1996. Multiple host defense defects in failure of C57BL/6 ep/ep (pale ear) mice to resolve visceral Leishmania donovani infection. Infect. Immun. 64:161-166.
294. Nabors, G. S., L. C. C. Afonso, J. P. Farrell, and P. Scott. 1995. Switch from a type 2 to type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. Proc. Natl. Acad. Sci. USA 92:3142-3146.
295. Nagai, H., J. Guo, H. Choi, and V. P. Kurup. 1995. Interferon-γ and tumor necrosis factor-α protect mice from invasive aspergillosis. J. Infect. Dis. 172:1554-1560.
296. Nakano, Y., K. Onozuka, Y. Terada, H. Shinomiya, and M. Nakano. 1990. Protective effect of recombinant tumor necrosis factor-α in murine salmonellosis. J. Immunol. 144:1935-1941.
297. + T cells and T-independent mechanisms in acquired resistance to Salmonella typhimurium infection. J. Immunol. 145: 1265-1269.
298. Nauciel, C., and F. Espinasse-Maes. 1992. Role of γ interferon and tumor necrosis factor α in resistance to Salmonella typhimurium infection. Infect. Immun. 60:450-454.
299. Neta, R., S. M. Stiefel, F. Finkelman, S. Herrmann, and N. Ali. 1994. IL-12 protects bone marrow from and sensitizes intestinal tract to ionizing radiation. J. Immunol. 153:4230-4238.
300. Newman, G. W., J. R. Guarnaccia, E. A. Vance III, J. Y. Wu, H. G. Remold, and P. H. Kazanjian, Jr. 1994. Interleukin-12 enhances antigen-specific proliferation of peripheral blood mononuclear cells from HIV-positive and negative donors in response to Mycobacterium avium. AIDS 8:1413-1419.
301. Noll, A., and I. B. Autenrieth. 1996. Immunity against Yersinia enterocolitica by vaccination with Yersinia HSP60 immunostimulating complexes or Yersinia HSP60 plus interleukin-12. Infect. Immun. 64:2955-2961.
302. O'Garra, A., and K. Murphy. 1994. Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol. 6:458-466.
303. O'Garra, A., and K. Murphy. 1995. T-cell subsets in autoimmunity. Curr. Opin. Immunol. 5:880-886.
304. Olivier, M., R. W. Brownsey, and N. E. Reiner. 1992. Defective stimulusresponse coupling in human monocytes infected with Leishmania donovani is associated with altered activation and translocation of protein kinase C. Proc. Natl. Acad. Sci. USA 89:7481-7485.
305. Orange, J. S., and C. Biron. 1996. An absolute and restricted requirement for interleukin-12 in natural killer (NK) cell interferon-γ production and antiviral defense: studies of NK and T-cell responses in contrasting viral infections. J. Immunol. 156:1138-1142.
306. Orange, J. S., and C. Biron. 1996. Characterization of early IL-12, IFN-αβ, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J. Immunol. 156:4746-4756.
307. Orange, J. S., T. P. Salazar-Mather, S. M. Opal, R. L. Spencer, A. H. Miller, B. S. McEwen, and C. A. Biron. 1995. Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids. J. Exp. Med. 181:901-914.
308. Orange, J. S., B. Wang, C. Terhorst, and C. A. Biron. 1995. Requirement for natural killer (NK) cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J. Exp. Med. 182:1045-1056.
309. Orange, J. S., S. F. Wolf, and C. A. Biron. 1994. Effects of IL-12 on the response and susceptibility to experimental viral infections. J. Immunol. 152:1253-1264.
310. Orme, I. M., E. S. Miller, A. D. Roberts, S. K. Furney, J. P. Griffin, K. M. Dobos, D. Chi, B. Rivoire, and P. J. Brennan. 1992. T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. J. Immunol. 148:189-196.
311. Orme, I. M., A. D. Roberts, J. P. Griffin, and J. S. Abrams. 1993. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J. Immunol. 151:518-525.
312. Oswald, I. P., I. Eltoum, T. A. Wynn, B. Schwartz, P. Caspar, D. Paulin, A. Sher, and S. L. James. 1994. Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schislosoma mansoni, through the production of nitric oxide. Proc. Natl. Acad. Sci. USA 91:999-1003.
313. Ozmen, L., M. Aguet, G. Trinchieri, and G. Garotta. 1995. The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon. J. Virol. 69:8147-8150.
314. Ozmen, L., M. Pericin, J. Hakimi, R. A. Chizzonite, M. Wysocka, G. Trinchieri, M. Gately, and G. Garotta. 1994. IL-12, IFN-γ, and TNF-α are the key cytokines of the generalized Shwartzmann reaction. J. Exp. Med. 180:907-916.
315. + T cell clones from HIV-infected patients. J. Clin. Invest. 96:1677-1682.
316. Parish, C. R. 1972. The relationship between humoral and cell-mediated immunity. Transplant. Rev. 13:35-66.
317. Paul, W. E., and R. A. Seder. 1994. Lymphocyte responses and cytokines. Cell 76:241-251.
318. Pearlman, E., F. P. Heinzel, F. E. Hazlett, Jr., and J. W. Kazura. 1995. IL-12 modulation of T helper responses to the filarial helminth, Brugia malayi. J. Immunol. 154:4658-4664.
319. Perales, M. A., P. R. Skolnik, and J. Lieberman. 1996. Effect of interleukin 12 on in vitro HIV type 1 replication depends on clinical stage. AIDS Res. Hum. Retroviruses 12:659-668.
320. Perez, V. L., J. A. Lederer, E. Carniel, A. Lichtman, and A. K. Abbas. 1995. The role of IL12 in helper T-cell differentiation. Res. Immunol. 146:477-480.
321. Perez, V. L., J. A. Lederer, A. H. Lichtman, and A. K. Abbas. 1995. Stability of Th1 and Th2 populations. Int. Immunol. 7:869-875.
322. + T lymphocytes and NK cells. J. Immunol. 149:3495-3502.
323. Podlaski, F. J., V. B. Nanduri, J. D. Hulmes, Y.-C. E. Pan, W. Levin, W. Danho, R. Chizzonite, M. K. Gately, and A. S. Stern. 1992. Molecular characterization of interleukin 12. Arch. Biochem. Biophys. 294:230-237.
324. Powrie, F., and R. L. Coffman. 1993. Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunol. Today 14:270-274.
325. Presky, D. H., U. Gubler, R. A. Chizzonite, and M. K. Gately. 1995. IL12 receptors and receptor antagonists. Res. Immunol. 146:439-445.
326. Presky, D. H., H. Yang, L. J. Minetti, A. O. Chua, N. Nabavi, C. Y. Wu, M. K. Gately, and U. Gubler. 1996. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93:14002-14007.
327. H2-like switch in candidiasis: new perspectives for therapy. Trends Microbiol. 3:237-240.
328. Radolf, J. D., L. L. Arndt, D. R. Akins, L. L. Curetty, M. E. Levi, Y. Shen, L. S. Davis, and M. V. Norgard. 1995. Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytes/macrophages. J. Immunol. 154:2866-2877.
329. Reed, S. G. 1988. In vivo administration of recombinant IFN-γ induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infection. J. Immunol. 140: 4342-4347.
330. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151-177.
331. + T cells during initiation of infection. J. Exp. Med. 179:447-456.
332. Remington, J. S., R. McLeod, and G. Desmonts. 1994. Toxoplasmosis, p. 140-267. In J. S. Remington, and J. O. Klein (ed.), Infectious diseases of the fetus and newborn infant, 4th ed. The W. B. Saunders Co., Philadelphia, Pa.
333. Rex, J. H., J. E. Bennett, J. I. Gallin, H. L. Malech, E. S. DeCarlo, and D. A. Melnick. 1991. In vivo interferon-γ therapy augments the in vitro ability of chronic granulomatous disease neutrophils to damage Aspergillus hyphae. J. Infect. Dis. 163:849-852.
334. Robinson, D. S., S. Ying, I. K. Taylor, A. Wangoo, D. M. Mitchell, A. B. Kay, Q. Hamid, and R. J. Shaw. 1994. Evidence for a Th1-like bronchoalveolar T-cell subset and predominance of interferon-gamma gene activation in pulmonary tuberculosis. Am. J. Respir. Crit. Care Med. 149:989-993.
335. Rogers, H. W., K. C. F. Sheehan, L. M. Brunt, S. K. Dower, E. R. Unanue, and R. D. Schrieber. 1992. Interleukin-1 participates in the development of anti-Listeria responses in both normal and SCID mice. Proc. Natl. Acad. Sci. USA 89:1011-1015.
336. Rogge, L., L. Barberis-Maino, M. Biffi, N. Passini, D. H. Presky, U. Gubler, and F. Sinigaglia. 1997. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:825-831.
337. H2 subsets: doubt no more. Immunol. Today 12:256-257.
338. Romagnani, S. 1992. Induction of Th1 and Th2 responses: a key role for the "natural" immune response? Immunol. Today 13:379-383.
339. Romagnani, S. 1994. Regulation of the development of type 2 T helper cells in allergy. Curr. Opin. Immunol. 6:838-846.
340. Romani, L., F. Bistoni, A. Mencacci, E. Cenci, R. Spaccapelo, and P. Puccetti. 1995. IL12 in Candida albicans infections. Res. Immunol. 146: 532-538.
341. Romani, L., F. Bistoni, and P. Puccetti. Initiation of T helper cell immunity to Candida albicans by IL-12: the role of neutrophils. Chem. Immunol., in press.
342. Romani, L., E. Cenci, A. Mencacci, F. Bistoni, and P. Puccetti. 1995. T helper cell dichotomy to Candida albicans: implications for pathology, therapy, and vaccine design. Immunol. Res. 14:148-162.
343. + subset expression in murine candidiasis. Infect. Immun. 60:4950-4952.
344. Romani, L., and D. H. Howard. 1995. Mechanisms of resistance to fungal infections. Curr. Opin. Immunol. 7:517-523.
345. + T helper subset selection in mice with candidiasis. J. Immunol. 158:2356-2362.
346. Romani, L., A. Mencacci, E. Cenci, P. Puccetti, and F. Bistoni. 1997. Neutrophils and the adaptive immune response to Candida albicans. Res. Immunol. 147:512-518.
347. Romani, L., A. Mencacci, E. Cenci, R. Spaccapelo, G. Del Sero, I. Nicoletti, G. Trinchieri, F. Bistoni, and P. Puccetti. 1997. Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice. J. Immunol. 158:5349-5356.
348. + T helper cell 1 development in interleukin-6-deficient mice infected with Candida albicans. J. Exp. Med. 183:1345-1355.
349. Romani, L., A. Mencacci, L. Tonnetti, R. Spaccapelo, E. Cenci, P. Puccetti, S. F. Wolf, and F. Bistoni. 1994. IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis. J. Immunol. 152:5167-5175.
350. Romani, L., A. Mencacci, L. Tonnetti, R. Spaccapelo, E. Cenci, S. Wolf, P. Puccetti, and F. Bistoni. 1994. Interleukin-12 but not interferon-γ production correlates with induction of T helper type-1 phenotype in murine candidiasis. Eur. J. Immunol. 24:909-915.
351. Romani, L., P. Puccetti, and F. Bistoni. 1996. Biological role of Th cell subsets in candidiasis. Chem. Immunol. 63:115-137.
352. Rothe, H., B. Hartmann, P. Geerlings, and H. Kolb. 1996. Interleukin-12 gene expression of macrophages is regulated by nitric oxide. Biochem. Biophys. Res. Commun. 224:159-163.
353. Rudin, W., H. P. Eugster, G. Bordmann, J. Bonato, M. Muller, M. Yamage, and B. Ryffel. 1997. Resistance to cerebral malaria in tumor necrosis factor α/β-deficient mice is associated with a reduction of intercellular adhesion molecule-1 up-regulation and T helper type 1 response. Am. J. Pathol. 150:257-266.
354. Ryffel, B. 1997. Interleukin-12: role of interferon-γ in IL-12 adverse effects. Clin. Immunol. Immunopathol. 83:18-20.
355. Salgame, P., J. S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R. L. Modlin, and B. R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 245:279-282.
356. Saunders, B. M., Y. Zhan, and C. Cheers. 1995. Endogenous interleukin-12 is involved in resistance of mice to Mycobacterium avium complex infection. Infect. Immun. 63:4011-4015.
357. + T cell subsets and induces early resistance to Leishmania major in mice. J. Exp. Med. 178: 567-577.
358. Scharton-Kersten, T., L. C. C. Afonso, M. Wysocka, G. Trinchieri, and P. Scott. 1995. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154:5320-5330.
359. Scharton-Kersten, T. M., E. Y. Denkers, R. T. Gazzinelli, and A. Sher. 1995. Role of IL12 in induction of cell-mediated immunity to Toxoplasma gondii. Res. Immunol. 146:539-545.
360. Scharton-Kersten, T. M., and P. Scott. 1995. The role of the innate immune response in Th1 cell development following Leishmania major infection. J. Leukocyte Biol. 57:515-522.
361. Scharton-Kersten, T. M., T. A. Wynn, E. Y. Denkers, S. Bala, E. Grunvald, S. Heiny, R. T. Gazzinelli, and A. Sher. 1996. In the absence of endogenous IFN-γ, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J. Immunol. 157:4045-4054.
362. Schijns, V. E. C. J., B. L. Haagmans, and M. C. Horzinek. 1995. IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-γ-receptor-deficient mice. J. Immunol. 155:2525-2532.
363. Schijns, V. E. C. J., B. L. Haagmans, E. O. Rijke, S. Huang, M. Aguet, and M. C. Horzinek. 1994. Interferon-γ receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses. J. Immunol. 153:2029-2037.
364. Schijns, V. E. C. J., C. M. H. Wierda, M. von Hoeji, and M. C. Horzinek. 1996. Exacerbated viral hepatitis in IFN-γ receptor-deficient mice is not suppressed by IL-12. J. Immunol. 157:815-821.
365. Schlaak, J., E. Hermann, M. Ringhoffer, P. Probst, H. Gallati, K. H. Meyer zum Büschenfelde, and B. Fleischer. 1992. Predominance of Th1-type T cells in synovial fluid with Yersinia-induced reactive arthritis. Eur. J. Immunol. 22:2771-2776.
366. + T cells. Eur. J. Immunol. 24:343-347.
367. Schoenhaut, D. S., A. O. Chua, A. G. Wolitzky, P. M. Quinn, C. M. Dwyer, W. McComas, P. C. Familletti, M. K. Gately, and U. Gubler. 1992. Cloning and expression of murine IL-12. J. Immunol. 148:3433-3440.
368. Scott, B., R. Liblau, S. Degermann, L. A. Marconi, L. Ogata, A. J. Canton, H. O. McDevitt, and D. Lo. 1994. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1:73-83.
369. Scott, P. 1993. IL-12: initiation cytokine for cell-mediated immunity. Science 260:496-497.
370. Scott, P. 1996. Th cell development and regulation in experimental cutaneous leishmaniasis. Chem. Immunol. 63:98-114.
371. Scott, P., and S. H. E. Kaufmann. 1991. The role of T-cell subsets and cytokines in the regulation of infection. Immunol. Today 12:346-348.
372. Sedegah, M., F. Finkelman, and S. L. Hoffman. 1994. Interleukin 12 induction of interferon γ-dependent protection against malaria. Proc. Natl. Acad. Sci. USA 91:10700-10702.
373. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188-10192.
374. Seder, R. A., B. L. Kelsall, and D. Janovic. 1996. Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease. J. Immunol. 157:2745-2748.
375. + T cells. Annu. Rev. Immunol. 12:635-673.
376. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091-1098.
377. Seiler, K. P., and J. J. Weiss. 1996. Immunity to Lyme disease: protection, pathology, and persistence. Curr. Opin. Immunol. 8:503-509.
378. Sher, A., and R. L. Coffman. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10:385-409.
379. Sher, A., R. L. Coffman, S. Heiny, and A. W. Cheever. 1990. Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fail to affect immunity against Schistosoma mansoni in the mouse. J. Immunol. 145:3911-3920.
380. Sher, A., R. T. Gazzinelli, I. P. Oswald, M. Clerici, M. Kullberg, E. J. Pearce, J. A. Berzofsky, T. R. Mosmann, S. L. James, H. C. Morse, and G. M. Shearer. 1992. Role of T-cell derived cytokines in the down-regulation of immune responses in parasitic and retroviral infection. Immunol. Rev. 127:183-204.
381. Sher, A., I. P. Oswald, S. Heiny, and R. T. Gazzinelli. 1993. Toxoplasma gondii induces a T-independent IFN-γ response in NK cells which requires both adherent accessory cells and TNF-α. J. Immunol. 150:3982-3989.
382. Sieburth, D., E. W. Jabs, J. A. Warrington, X. Li, J. Lasota, S. LaForgia, K. Kelleher, K. Huebner, J. J. Wasmuth, and S. F. Wolf. 1992. Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics 14:59-62.
383. Sieling, P. A., X.-H. Wang, M. K. Gately, J. L. Oliveros, T. McHugh, P. F. Barnes, S. F. Wolf, L. Golkar, M. Vamamura, Y. Yogi, K. Uyemura, T. H. Rea, and R. L. Modlin. 1994. IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J. Immunol. 153:3639-3647.
384. Silva, J. S., P. J. Morrissey, K. H. Grabstein, K. M. Mohler, D. Anderson, and S. G. Reed. 1992. Interleukin 10 and IFN-γ regulation of experimental Trypanosoma cruzi infection. J. Exp. Med. 175:169-174.
385. Silva, J. S., D. Twardzik, and S. G. Reed. 1991. Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor-beta. J. Exp. Med. 174:539-545.
386. Sirianni, M. C., I. J. Ansotegui, F. Aiuti, and H. Wigzell. 1995. Natural killer cell stimulatory (NKSF)/IL-12 and cytolytic activities of PBL/NK cells from human immunodeficiency virus type-1 infected patients. Scand. J. Immunol. 40:83-86.
387. + T cells of primed humans. Immunology 76:584-592.
388. Skamene, E., P. Gros, A. Forget, P. A. L. Kongshavn, C. St. Charles, and B. A. Taylor. 1982. Genetic regulation of resistance to intracellular pathogens. Nature 297:506-509.
389. Skeen, M. J., M. A. Miller, T. M. Shinnick, and H. K. Ziegler. 1996. Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. J. Immunol. 156:1196-1206.
390. Skeen, M. J., and H. K. Ziegler. 1995. Activation of γδ T cells for production of IFN-γ is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12. J. Immunol. 154:5832-5841.
391. Skeiky, Y. A. W., J. A. Guderian, D. R. Benson, O. Bacelar, E. M. Carvalho, M. Kubin, R. Badaro, G. Trinchieri, and S. G. Reed. 1995. A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12. J. Exp. Med. 181:1527-1537.
392. Smith, T. J., L. A. Ducharme, and J. H. Weis. 1994. Preferential expression of interleukin-12 or interleukin-4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin-3. Eur. J. Immunol. 24:822-826.
393. Smythies, L. E., P. S. Coulson, and R. A. Wilson. 1992. Monoclonal antibody to IFN-γ modifies pulmonary inflammatory responses and abrogates immunity to Schistosoma mansoni in mice vaccinated with attenuated cercariae. J. Immunol. 149:3654-3658.
394. Snidjers, A., C. M. Hilkens, T. C. van der Pouw Kraan, M. Engel, L. A. Aarden, and M. L. Kapsenberg. 1996. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J. Immunol. 156:1207-1212.
395. Song, F., G. Matsuzaki, M. Mitsuyama, and K. Nomoto. 1996. Differential effects of viable and killed bacteria on IL-12 expression of macrophages. J. Immunol. 156:2979-2984.
396. Spaccapelo, R., L. Romani, L. Tonnetti, E. Cenci, A. Mencacci, G. Del Sero, R. Tognellini, S. Reed, P. Puccetti, and F. Bistoni. 1995. TGF-β is important in determining the in vivo patterns of susceptibility or resistance in mice infected with Candida albicans. J. Immunol. 155:1349-1360.
397. Stahl, N., and G. D. Yancopoulos. 1993. The alphas, betas and kinases of cytokine receptor complexes. Cell 74:587-590.
398. Stern, A. S., F. J. Podlaski, J. D. Hulmes, Y. E. Pan, P. M. Quinn, A. G. Wolitzky, P. C. Familletti, D. L. Stremio, T. Truitt, R. Chizzonite, and M. K. Gately. 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 87:6808-6812.
399. Stevens, D. A. 1995. Coccidioides immitis, p. 2365-2375. In G. L. Mandell, J. E. Bennett, and R. Dolin (ed.), Principles and practice of infectious disease, 4th ed. Churchill Livingstone. Inc., New York, N.Y.
400. Stevens, M. G., G. W. Pugh, and L. B. Tabatabai. 1992. Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice. Infect. Immun. 60:4407-4409.
401. Stevenson, M. M., M. F. Tam, S. F. Wolf, and A. Sher. 1995. IL-12-induced protection against blood-stage Plasmodium chabaudi AS requires IFN-γ and TNF-α and occurs via a nitric oxide-dependent mechanism. J. Immunol. 155:2545-2556.
402. + T cells. Int. Immunol. 8:877-883.
403. Swain, S. L. 1993. IL-4 dictates T-cell differentiation. Res. Immunol. 144: 567-651.
404. Swain, S. L., L. M. Bradley, M. Croft, S. Tonkonogy, G. Atkins, A. D. Weinberg, D. D. Duncan, S. M. Hedrick, R. W. Dutton, and G. Huston. 1991. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol. Rev. 123:115-144.
405. Sypek, J. P., C. L. Chung, S. E. H. Mayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis. Interleukin 12 initiates a protective Th1 immune response. J. Exp. Med. 177:1797-1802.
406. Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1997. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817-824.
407. Szabo, S. J., N. G. Jacobson, A. S. Dighe, U. Gubler, and K. M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2:665-675.
408. Takenaka, H., S. Maruo, N. Yamamoto, M. Wysocka, S. Ono, M. Kobayashi, H. Yagita, K. Okumura, T. Hamaoka, G. Trinchieri, and H. Fujiwara. 1997. Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4. J. Leukocyte Biol. 61:80-87.
409. Tang, Y. W., and B. S. Graham. 1995. Interleukin-12 treatment during immunization elicits a T helper cell type 1-like immune response in mice challenged with respiratory syncytial virus and improves vaccine immunogenicity. J. Infect. Dis 172:734-738.
410. Taoufik, Y., O. Lantz, C. Wallon, A. Charles, E. Dussaix, and J. F. Delfraissy. 1997. Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood 89:2842-2848.
411. Taylor, A. P., and H. W. Murray. 1997. Intracellular antimicrobial activity in the absence of interferon-γ: effect of interleukin-12 in experimental visceral leishmaniasis in interferon-γ gene-disrupted mice. J. Exp. Med. 185:1231-1239.
412. Teixeira, H. C., M. E. Munk, and S. H. E. Kaufmann. 1995. Frequencies of IFN-γ and IL-4 producing cells during Mycobacterium bovis BCG infection in two genetically susceptible mouse strains: role of α/β T cells and NK1.1 cells. Immunol. Lett. 46:15-19.
413. Thierfelder, W. E., J. M. van Deursen, K. Yamamoto, R. A. Tripp, S. R. Sarawar, R. T. Carson, M. Y. Sangster, D. A. Vignali, P. C. Doherty, G. C. Grosveld, and J. N. Ihle. 1996. Requirement for Stat4 in interleukin 12-mediated responses of natural killer and T cells. Nature 382:171-174.
414. Tite, J. P., G. Dougan, and S. N. Chatfield. 1991. The involvement of tumor necrosis factor in immunity to Salmonella infection. J. Immunol. 147:3161-3164.
415. Tone, Y., S. A. Thompson, J. M. Babik, K. F. Nolan, M. Tone, C. Raven, and H. Waldmann. 1996. Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes. Eur. J. Immunol. 26:1222-1227.
416. H1 cells. Immunol. Today 14:335-338.
417. Trinchieri, G. 1995. Interleukin-12: a pro-inflammatory cytokine with immunoregulatory functions that bridges innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:252-276.
418. Trinchieri, G. 1996. Role of interleukin-12 in human Th1 response. Chem. Immunol. 63:14-29.
419. Trinchieri, G. 1997. Function and clinical use of interleukin-12. Curr. Opin. Hematol. 4:59-66.
420. Trinchieri, G., and F. Gerosa. 1996. Immunoregulation of interleukin-12. J. Leukocyte Biol. 59:505-511.
421. Trinchieri, G., and P. Scott. 1994. The role of interleukin 12 in the immune response, disease and therapy. Immunol. Today 15:460-463.
422. Trinchieri, G., and P. Scott. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions. Res. Immunol. 146:423-431.
423. Tripp, C. S., M. K. Gately, J. Hakimi, P. Ling, and E. R. Unanue. 1994. Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-γ. J. Immunol. 152:1883-1887.
424. Tripp, C. S., O. Kanagawa, and E. R. Unanue. 1995. Secondary response to Listeria infection requires IFN-γ but is partially independent of IL-12. J. Immunol. 155:3427-3432.
425. Tripp, C. S., and E. R. Unanue. 1995. Macrophage production of IL12 is a critical link between the innate and specific immune responses to Listeria. Res. Immunol. 146:515-519.
426. Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency with listeriosis and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725-3729.
427. Uehara, S., Y. Hitoshi, F. Numata, M. Makino, M. Howard, T. Mizuochi, and K. Takatsu. 1994. An IFN-γ-dependent pathway plays a critical role in the pathogenesis of murine immunodeficiency syndrome induced by LP-BM5 murine leukemia virus. Int. Immunol. 6:1937-1947.
428. Uherova, P., E. Connick, S. MaWhinney, R. Schlichtemeier, R. T. Schooley, and D. R. Kuritzkes. 1996. In vitro effect of interleukin-12 on antigen-specific lymphocyte proliferative responses from persons infected with human immunodeficiency virus type 1. J. Infect. Dis. 174:483-489.
429. Ungar, B. L. P., J. A. Burris, C. A. Quinn, and F. D. Finkelman. 1990. New mouse models for chronic Cryptosporidium infection in immunodeficient hosts. Infect. Immun. 58:961-969.
430. Ungar, B. L. P., T. C. Kao, J. A. Burris, and F. D. Finkelman. 1991. Cryptosporidium infection in an adult mouse model: independent roles for IFN-γ and CD4 T lymphocytes in protective immunity. J. Immunol. 147: 1014-1022.
431. Urban, J., K. Madden, A. Svetic, A. Cheever, P. Trotta, W. Gause, I. Katona, and F. Finkelman. 1992. The importance of Th2 cytokines in protective immunity to nematodes. Immunol. Rev. 127:205-210.
432. Urban, J. F., Jr., R. Fayer, S.-J. Chen, W. C. Gause, M. K. Gately, and F. D. Finkelman. 1996. IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum. J. Immunol. 156:263-268.
433. 2 is a potent inhibitor of human interleukin 12 production. J. Exp. Med. 181:775-779.
434. Vezzio, N., M. Sarfati, L. P. Yang, C. E. Demeure, and G. Delespesse. 1996. Human Th2-like cell clones induce IL-12 production by dendritic cells and may express several cytokine profiles. Int. Immunol. 8:1963-1970.
435. Vieira, L. Q., B. D. Hondowicz, L. C. C. Afonso, M. Wysocka, G. Trinchieri, and P. Scott. 1994. Infection with Leishmania major induces interleukin-12 production in vivo. Immunol. Lett. 40:157-161.
436. Voest, E. E., B. M. Kenyon, G. A. Truitt, M. S. O'Reilly, R. J. D'Amato, and J. Folkman. 1995. Interleukin 12 inhibits angiogenesis in vivo. J. Natl. Cancer Inst. 87:581-586.
437. Vogel, L. A., L. C. Showe, T. L. Lester, R. M. McNutt, V. H. Van Cleave, and D. W. Metzger. 1996. Direct binding of IL-12 to human and murine B lymphocytes. Int. Immunol. 8:1955-1962.
438. Wagner, R. D., H. Steinberg, H. Brown, and C. J. Czuprynski. 1994. Recombinant interleukin-12 enhances resistance of mice to Listeria monocytogenes infection. Microb. Pathog. 17:175-186.
439. Walsh, T. J., J. Hiemenz, and P. A. Pizzo. 1994. Evolving risk factors for invasive fungal infections: All neutropenic patients are not the same. Clin. Infect. Dis. 18:793-798.
440. Wang, B., C. Biron, J. She, K. Higgins, M.-J. Sunshine, E. Lacy, N. Lonberg, and C. Terhorst. 1994. A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3ε gene. Proc. Natl. Acad. Sci. USA 91:9402-9406.
441. + effector cells default to the Th2 pathway in interferon-γ-deficient mice infected with Leishmania major. J. Exp. Med. 179:1367-1371.
442. Wang, Z.-E., S. Zheng, D. B. Corry, D. K. Dalton, R. A. Seder, S. L. Reiner, and R. M. Locksley. 1994. Interferon γ-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Proc. Natl. Acad. Sci. USA 91:12932-12936.
443. Wolf, S. F., J. Bliss, K. Stokes, and J. Sypek. 1995. Activity of IL12 as adjuvant in promoting Th1 and Th2 recall responses. Res. Immunol. 146: 486-493.
444. Wolf, S. F., P. A. Temple, M. Kobayashi, D. Young, M. Dicig, L. Lowe, R. Dzialo, L. Fitz, C. Ferenz, R. M. Hewick, K. Kelleher, S. Hermann, S. C. Clark, L. Azzoni, S. H. Chan, G. Trinchieri, and B. Perussia. 1991. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146:3074-3081.
445. Wu, C.-Y., C. E. Demeure, M. Gately, F. Podlaski, H. Yssel, M. Kiniwa, and G. Delespesse. 1994. In vitro maturation of human neonatal CD4 T lymphocytes. J. Immunol. 152:1141-1153.
446. Wu, C.-Y., R. R. Warrier, D. M. Carvajal, A. O. Chua, L. J. Minetti, R. Chizzonite, P. K. A. Mongini, A. S. Stern, U. Gubler, D. H. Presky, and M. K. Gately. 1996. Biological function and distribution of human interleukin-12 receptor β chain. Eur. J. Immunol. 26:345-350.
447. Wu, C. Y., R. R. Warrier, X. Wang, D. H. Presky, and M. K. Gately. 1997. Regulation of interleukin-12 receptor β1 chain expression and interleukin-12 binding by human peripheral blood mononuclear cells. Eur. J. Immunol. 27:147-154.
448. Wu-Hsieh, B. A., and D. H. Howard. 1987. Inhibition of the intracellular growth of Histoplasma capsulatum by recombinant murine gamma interferon. Infect. Immun. 55:1014-1016.
449. Wynn, T. A., A. W. Cheever, D. Jankovic, R. W. Poindexter, P. Caspar, F. A. Lewis, and A. Sher. 1995. An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature (London) 376:594-597.
450. Wynn, T. A., I. Eltoum, I. P. Oswald, A. W. Cheever, and A. Sher. 1994. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J. Exp. Med. 179:1551-1561.
451. Wynn, T. A., D. Jankovic, S. Hieny, A. W. Cheever, and A. Sher. 1995. IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia. J. Immunol. 154:4701-4709.
452. Wynn, T. A., D. Jankovic, S. Hieny, K. Zioncheck, P. Jardieu, A. W. Cheever, and A. Sher. 1995. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ. J. Immunol. 154:3999-4009.
453. Wynn, T. A., A. Reynolds, S. James, A. W. Cheever, P. Caspar, S. Heiny, D. Jankovic, M. Strand, and A. Sher. 1996. IL-12 enhances vaccine-induced immunity to schistosomes augmenting both humoral and cell-mediated immune responses against the parasite. J. Immunol. 157:4068-4078.
454. Wynn, T. A., and A. Sher. 1995. IL12 as an adjuvant for vaccines designed to prevent infection and immunopathology by schistosomes. Res. Immunol. 146:582-589.
455. Wysocka, M., M. Kubin, L. Q. Vieira, L. Ozmen, G. Garotta, P. Scott, and G. Trinchieri. 1995. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:672-676.
456. Yamashita, T., and D. L. Boros. 1992. IL-4 influences IL-2 production and granulomatous inflammation in murine Schistosoma mansoni. J. Immunol. 149:3659-3664.
457. Yang, D. M., N. Fairweather, L. L. Button, W. R. McMaster, L. P. Kahl, and F. Y. Liew. 1990. Oral Salmonella typhimurium (AroA-) vaccine expressing a major leishmanial surface protein (gp63) preferentially induces T helper 1 cells and protective immunity against leishmaniasis. J. Immunol. 145: 2281-2285.
458. Yang, L., J. H. Weis, E. Eichwald, C. P. Kolbert, D. H. Persing, and J. J. Weis. 1994. Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues. Infect. Immun. 62:492-500.
459. Yang, Y., G. Trinchieri, and J. M. Wilson. 1995. Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nat. Med. 1:890-893.
460. Yap, G. S., P. Jacobs, and M. M. Stevenson. 1994. Th cell regulation of host resistance to blood-stage Plasmodium chabaudi AS. Res. Immunol. 145: 419-422.
461. Yoshida, A., Y. Koide, M. Uchijima, and T. O. Yoshida. 1995. Dissection of strain difference in acquired protective immunity against Mycobacterium bovis Calmette-Guérin bacillus (BCG). Macrophages regulate the susceptibility through cytokine network and the induction of nitric oxide synthase. J. Immunol. 155:2057-2066.
462. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285-1295.
463. Yssel, H., M.-C. Shanafelt, C. Soderberg, P. V. Schneider, J. Anzola, and G. Peltz. 1991. Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis. J. Exp Med. 174:593-601.
464. + T cells express Th1-like cytokine mRNA and protein following in vitro stimulation with heat-inactivated Brucella abortus. Infect. Immun. 63:2720-2728.
465. Zaitseva, M., H. Golding, J. Manischewitz, D. Webb, and B. Golding. 1996. Brucella abortus as a potential vaccine candidate: induction of interleukin-12 secretion and enhanced B7.1 and B7.2 and intracellular adhesion molecule 1 surface expression in elutriated human monocytes stimulated by heat-inactivated B. abortus. Infect. Immun. 64:3109-3117.
466. Zhan, Y., and C. Cheers. 1993. Endogenous gamma interferon mediates resistance to Brucella abortus infection. Infect. Immun. 61:4899-4901.
467. Zhan, Y., and C. Cheers. 1995. Endogenous interleukin-12 is involved in resistance to Brucella abortus infection. Infect. Immun. 63:1387-1390.
468. Zhan, Y., Z. Liu, and C. Cheers. 1996. Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms. Infect. Immun. 64:2782-2786.
469. Zhang, M., M. K. Gately, E. Wang, S. F. Wolf, S. Lu, R. L. Modlin, and P. F. Barnes. 1994. Interleukin-12 at the site of disease in tuberculosis. J. Clin. Invest. 93:1733-1739.
470. Zhang, M., J. Gong, D. V. Iyer, B. E. Jones, R. L. Modlin, and P. F. Barnes. 1994. T-cell cytokine responses in persons with tuberculosis and human immunodeficiency virus infection. J. Clin. Invest. 94:2435-2442.
471. Zhang, M., Y. Lin, D. V. Iyer, J. Gong, J. S. Ahrams, and P. F. Barnes. 1995. T-cell cytokine responses in human infection with Mycobacterium tuberculosis. Infect. Immun. 63:3231-3234.
472. Zhou, P., M. C. Sieve, J. Bennett, K. J. Kwon-Chung, R. P. Tewari, R. T. Gazzinelli, A. Sher, and R. A. Seder. 1995. IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ. J. Immunol. 155:785-795.
473. Zhou, P., M. C. Sieve, R. P. Tewari, and R. A. Seder. 1997. Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum. Infect. Immun. 65:936-942.
474. Zitvogel, L., and M. T. Lotze. 1995. Role of interleukin-12 (IL12) as an anti-tumour agent: experimental biology and clinical application. Res. Immunol. 146:628-638.
475. Zou, J., D. H. Presky, C. Y. Wu, and U. Gubler. 1997. Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits β1 and β2 and JAK kinases. J. Biol. Chem. 272:6073-6077.
476. Zou, J. J., D. S. Schoenhaut, D. M. Carvajal, R. R. Warrier, D. H. Presky, M. K. Gately, and U. Gubler. 1995. Structure-function analysis of the p35 subunit of mouse interleukin 12. J. Biol. Chem. 270:5864-5871.