IL-12 is essential for resistance against Yersinia enterocolitica by triggering IFN-γ production in NK cells and CD4+ T cells

Journal of Immunology

Volumn 156, Issue 4, 1996, Pages 1458-1468

  Bohn, Erwin ^a   Autenrieth, Ingo B ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; MESSENGER RNA; RECOMBINANT INTERLEUKIN 12;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; FEMALE; GRAM NEGATIVE INFECTION; HOST RESISTANCE; INFECTION RESISTANCE; INTERFERON PRODUCTION; MACROPHAGE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; YERSINIA ENTEROCOLITICA;

ANIMALS; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; DNA PRIMERS; FEMALE; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; KILLER CELLS, NATURAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PEYER'S PATCHES; SPLEEN; YERSINIA ENTEROCOLITICA; YERSINIA INFECTIONS;

EID: 0030058618     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Cornelis, G , Y Laroche, G. Balligand, M. P. Sory, and G. Wauters. 1987. Yersinia enterocolitica, a primary model for bacterial invasiveness. Rev Infect Dis. 9:64
2. Cover, T. L., and R C. Aber. 1989. Yersinia enterocolitica. N. Engl. J. Med. 321:16
3. Heesemann, J., K Gaede, and I. B Autenrieth 1993. Experimental Yersinia enterocolitica infection in rodents: a model for human yersiniosis. APMIS 101. 417.
4. Bouza, E., A Dominguez, M. Meseguer, L. Buzon, D. Boixeda, M. J. Revillo, L de Rafael, and J Martinez Beltran 1980. Yersinia enterocolitica septicemia. Am J. Clin Pathol. 74:404
5. Rabson, A. R., A. F. Hallett, and H. J. Koornhof. 1975. Generalized Yersinia enterocolitica infection. J. Infect Dis 131:447.
6. Autenrieth, I. B , P Hantschmann, B. Heymer, and J. Heesemann 1993. Immunohistological characterization of the cellular immune response against Yersinia enterocolitica in mice: evidence for the involvement of T lymphocytes. Immunobiology 187:1.
7. Autenrieth, I. B , A. Tingle, A Reske Kunz, and J. Heesemann. 1992. T lymphocytes mediate protection against Yersinia enterocolitica in mice: characterization of murine T-cell clones specific for Y enterocolitica Infect Immun. 60. 1140.
8. Autenrieth, I. B., M. Beer, P. Hantschmann, S. Preger, U Vogel, B. Heymer, and J. Heesemann. 1993. The cellular immune response against Yersinia enterocolitica in different inbred strains of mice, evidence for an important role of T lymphocytes Int. J. Med. Microbiol. Virol. Parasitol Infect. Dis. 278:383.
9. Autenrieth, I. B., U. Vogel, S. Preger, B. Heymer, and J. Heesemann. 1993. Experimental Yersinia enterocolitica infection in euthymic and T-cell-deficient athymic nude C57BL/6 mice: comparison of time course, histomorphology, and immune response Infect. Immun. 61:2585
10. Autenrieth, I. B., and J. Heesemann. 1992 In vivo neutralization of tumor necrosis factor alpha and interferon-gamma abrogates resistance to Yersinia enterocolitica in mice. Med. Microbiol Immunol. 181.333.
11. Autenrieth, I. B., M. Beer, E. Bohn, S H E Kaufmann, and J. Heesemann 1994. Immune responses to Yersinia enterocolitica in susceptible BALB/c and resistant C57BL/6 mice: an essential role for gamma Interferon. Infect. Immun. 62.2590.
12. Hancock, G. E., R. W. Schaedler, and T T. MacDonald. 1986. Yersinia enterocolitica infection in resistant and susceptible strains of mice. Infect. Immun. 53: 26.
13. Hancock, G. E., R. W. Schaedler, and T T MacDonald. 1988 Multigenic control of resistance to Yersinia enterocolitica in inbred strains of mice Infect Immun. 56:532.
14. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchien. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
15. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M Kubin, M Aste, S. H Chan, M. Kobayashi, D Young, E Nickbarg, R. Chizzonice, S F. Wolf, and G Trinchieri. 1992 Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells J. Exp. Med 176:1387.
16. Schoenhaut, D S., A O. Chua, A G. Wolitzky, P M. Quinn, C. M. Dwyer, W. McComas, P. C. Familletti, M. K. Gately, and U. Gubler. 1992. Cloning and expression of murine IL-12. J Immunol. 148:3433
17. Brunda, M J. 1994. Interleukin-12 J. Leukocyte Biol. 55:280.
18. Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interteukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist Proc. Natl Acad. Sci USA 90:3725.
19. Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts [see comments] Proc. Natl. Acad Sci. USA 90:6115.
20. D'Andrea, A , M. Aste Amezaga, N M Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells J. Exp. Med. 178:1041.
21. + T cells through IL-12 produced by Listeria-induced macrophages [see comments]. Science 260:547.
22. + T cells Eur. J Immunol. 24.343
23. + T cells requires the coordinate action of interleukin-12 and interferon-gamma and is inhibited by transforming growth factor-beta. Eur. J. Immunol. 24:793
24. Chehimi, J , and G. Trinchieri. 1994. Interleukin-12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency. J. Clin. Immunol. 14:149.
25. Tripp, C. S., M. K. Gately, J. Hakimi, P. Ling, and E. R. Unanue. 1994. Neutralization of IL-12 decreases resistance to Listeria in SCID and C B-17 mice. Reversal by IFN-gamma. J. Immunol. 152:1883.
26. Heinzel, F. P., D. S. Schoenhaut, R. M Rerko, L. E. Rosser, and M K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505.
27. Sypek, J. P., C. L. Chung, S. E. Mayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response J. Exp Med. 177:1797.
28. Goding, J. W. 1986. Monoclonal Antibodies: Principle and Practice, 2nd Ed Academic Press, London, p. 262.
29. Heinzel, F. P , R M. Rerko, P. Ling, J. Hakimi, and D. S. Schoenhaut. 1994. Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect Immun 62:4244.
30. Autenrieth, I B. A , E. Bohn, J. H. Ewald, and J Heesemann. 1995. Deferoxamine B but not deferoxamine G1 inhibits cytokine production in murine bone marrow macrophages J. Infect. Dis. 172:490.
31. Fischer, H G., S. Frosch, K. Reske, and A. B Reske Kunz. 1988. Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function. J. Immunol. 141:3882.
32. Bohn, E , J Heesemann, S. Ehlers, and I. B. Autenrieth. 1994. Early gamma interferon mRNA expression is associated with resistance of mice against Yersinia enterocolitica. Infect. Immun. 62:3027.
33. Gazzinelli, R. T , M. Wysocka, S. Hayashi, E. Y. Denkers, S. Hieny, P. Caspar, G. Trinchien, and A. Sher. 1994 Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasina gondu. J Immunol 153:2533
34. Kagnoff, M. F. 1993. Immunology of the intestinal tract Gastroenterology 105. 1275.
35. Grutzkau, A , C. Hanski, H. Hahn, and E O Riecken 1990. Involvement of M cells in the bacterial invasion of Peyer's patches: a common mechanism shared by Yersinia enterocolitica and other enteroinvasive bacteria. Gut 31:1011.
36. Autenrieth, I. B , and R Firsching. 1996. Penetration of M-cells and destruction of Peyer's patches by Yersinia enterocolitica an ultrastructural and histological study J Med. Microbiol. 44:1.
37. Cooper, A. M , A. D. Roberts, E. R. Rhoades, J. E. Callahan, D M. Getzy, and I M. Orme. 1995. The role of interleukin-12 in acquired immunity to Mycobacterium Tuberculosis infection. Immunology 84:423.
38. Flynn, J L., M M Goldstein, K. J. Triebold, J. Sypek, S. Wolf, and B. R. Bloom. 1995. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection J. Immunol 155 2515.
39. Orange, J. S., S. F Wolf, and C. A. Biron. 1994. Effects of IL-12 on the response and susceptibility to experimental viral infections, J. Immunol. 152:1253.
40. Gately, M. K., R R. Warrier, S. Honasoge, D. M. Carvajal, D A Faherty, S. E. Connaughton, T. D. Anderson, U. Sarmiento, B. R Hubbard, and M. Murphy. 1994 Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo. Int. Immunol. 6:157.
41. Ozmen, L., M. Pericin, J Hakimi, R A Chizzonite, M Wysocka, G. Trinchien, M. Gately, and G. Garotta 1994. Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction. J. Exp Med. 180:907
42. Ling, P , M. K. Gately, U. Gubler, A. S. Stern, P. Lin, K. Hollfelder, C. Su, Y. C. Pan, and J. Hakimi 1995. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J. Immunol 154:116.
43. Gillessen, S., D. Carvajal, P. Ling, F. J. Podlaski, D. L. Stremlo, P. C. Familletti, U. Gubler, D. H. Presky, A. S. Stern, and M. K. Gately. 1995. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 25: 200.
44. Mattner, F., S. Fischer, S. Guckes, S. Jin, H. Kanlen, E. Schmitt, E. Rude, and T. Germann. 1993. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 23:2202.
45. Bette, M., S C Jin, T. Germann, M. K. Schafer, E. Weihe, E. Rude, and B. Fleischer. 1994. Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ. Eur. J. Immunol. 24:2435.
46. Romani, L., A. Mencacci, L. Tonnetti, R. Spaccapelo, E. Cenci, S. Wolf, P Puccetti, and F. Bistoni. 1994. Interleukin-12 but not interferon-gamma production correlates with induction of T helper type-1 phenotype in murine candidiasis Eur. J. Immunol. 24:909.
47. Morris, S. C., K. B Madden, J J. Adarnovicz, W. C. Gause, B. R. Hubbard, M K Gately, and F. D. Finkelman. 1994. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J. Immunol 152:1047.
48. Hunter, C. A., L. Bermudez, H. Beernink, W. Waegell, and J. S. Remington. 1995 Transforming growth factor-beta inhibits interleukin-12-induced production of interferon-gamma by natural killer cells: a role for transforming growth factor-beta in the regulation of T cell-independent resistence to Toxoplasma gondii. Eur. J. Immunol. 25:994.
49. Flesch, I. E., J. H. Hess, S Huang, M. Aguet, S. Rotche. H. Bluethmann, and S. H Kaufmann. 1995 Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis, factor alpha. J. Exp. Med. 181:1615.
50. Germann, T., M. K. Gately, D. S. Schoenhaut, M Lohoff, F. Mattner, S Fischer, S. C. Jin, E. Schmitt, and E. Rude. 1993. Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells. Eur. J. Immunol. 23:1762.
51. Staats, H. F., R. J. Jackson, M. Marinaro, I. Takahashi, H. Kiyono, and J R. McGhee. 1994. Mucosal immunity to infection with implications for vaccine development Curr. Opin. Immunol. 6:572.
52. Carter, P. B., and F. M. Collins. 1974. Experimental Yersinia enterocolitica infection in mice kinetics of growth. Infect. Immun. 9:851
53. Carter, P. B. 1975. Pathogenecity of Yersinia enterocolitica for mice Infect. Immun. 11:164
54. Carter, P. B. 1975. Animal model of human disease, Yersinia enteritis. Animal model: oral Yersinia enterocolitica infection of mice. Am. J. Pathol. 81:703.