Priming with IFN-γ Restores Deficient IL-12 Production by Peripheral Blood Mononuclear Cells from HIV-Seropositive Donors

Journal of Immunology

Volumn 158, Issue 1, 1997, Pages 459-463

  Harrison, Thomas S ^a   Levitz, Stuart M ^a  

^a BOSTON MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; BIOSYNTHESIS; DRUG EFFECT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNIZATION; IMMUNOLOGY; METABOLISM; MONONUCLEAR CELL;

ACQUIRED IMMUNODEFICIENCY SYNDROME; HIV SEROPOSITIVITY; HUMANS; IMMUNIZATION; INTERFERON TYPE II; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR;

EID: 0030641331     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Fauci, A. S. 1993. Muitifactorial nature of human immunodeficiency virus disease: implications for therapy. Science 262:1011.
2. Clerici, M., F. T. Hakim, D. J. Venzon, S. Blatt, C. W. Hendrix, T. A. Wynn, and G. M. Shearer. 1993. Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. J. Clin. Invest. 91:759.
3. Maggi, E., M. Mazzetti, A. Ravina, F. Annunziato, M. de Carli, M. P. Piccinni, R. Manetti, M. Carbonari, A. M. Pesce, G. del Prete, and S. Romagnani. 1994. Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and THO cells. Science 265:244.
4. Trinchieri, G. 1994. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008.
5. Hendrzak, J. A., and M. J. Brunda. 1995. Biology of disease. Interleukin-12: biologic activity, therapeutic utility, and role in disease. Lab. Invent. 72:619.
6. Chehimi, J., S. E. Starr, I. Frank, A. D'Andrea, X. Ma, R. R. MacGregor, J. Sennelier, and G. Trinchieri. 1994. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J. Exp. Med. 179:1361.
7. Clerici, M., D. R. Lucey, J. A. Berzofsky, L. A. Pinto, T. A. Wynn, S. P. Blatt, M. J. Dolan, C. W. Hendrix, S. F. Wolf, and G. M. Shearer. 1993. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 262:1721.
8. Zhang, M., J. Gong, D. V. Iyer, B. E. Jones, R. L. Modlin, and P. F. Barnes. 1994. T cell cytokine responses in persons with tuberculosis and human immunodeficiency virus infection. J. Clin. Invest. 94:2435.
9. Harrison, T. S., and S. M. Levitz. 1996. Role of IL-12 in PBMC responses to fungi in persons with and without HIV infection. J. Immunol. 156:4492.
10. Kubin, M., J. M. Chow, and O. Trinchieri. 1994. Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood 83:1847.
11. Hayes, M. P., J. H. Wang, and M. A. Norcross. 1995. Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blond 86:646.
12. Flesch, I. E., J. H. Hess, S. Huang, M. Aguet, J. Rothe, H. Bluethmann, and S. H. Kaufmann. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha. J. Exp. Med 181:1615.
13. Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocyte cells. J. Exp. Med. 183:147.
14. Graziosi, C., G. Pantaleo, K. R. Gantt, J. P. Fortin, J. F. Demarest, O. J. Cohen, R. P. Sekaly, and A. S. Fauci. 1994. Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science 265:248.
15. Murray, H. W., B. Y. Rubin, H. Masur, and R. B. Roberts. 1984. Impaired production of lymphokines and immune gamma interferon in the acquired immunodeficiency syndrome. N. Engl. J. Med. 310:883.
16. Murray, H. W., J. K. Hillman, B. Y. Rubin, C. D. Kelly, J. L. Jacobs, L. W. Tyler, D. M. Donelly, S. M. Carriero, J. H. Godbold, and R. B. Roberts. 1985. Patients at risk for AIDS-related opportunistic infections: clinical manifestations and impaired gamma interferon production. N. Engl. J. Med. 313:1504.
17. Gazzinelli, R. T., S. Bala, R. Stevens, M. Baseler, L. Wahl, J. Kovacs, and A. Sher. 1995. HIV infection suppresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokines. J. Immunol. 155:1565.
18. Levitz, S. M., A. Tabuni, H. Kornfeld, C. C. Reardon, and D. T. Golenbock. 1994. Production of tumor necrosis factor-alpha in human leukocytes stimulated by Cryptococcus neoformans. Infect. Immun. 62:1975.
19. Treseler, C. B., R. T. Maziarz, and S. M. Levitz. 1992. Biological activity of interleukin-2 bound to Candida albicans. Infect. Immun. 60:183.
20. Levitz, S. M., A. Tabuni, S.-H. Nong, and D. T. Golenbock. 1996. Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans. Candida albicans, and lipopolysaccharide. Infect. Immun. 64:945.
21. Chougnet, C., T. A. Wynn, M. Clerici, A. L. Landay, H. A. Kessler, J. Rusnak, G. P. Melcher, A. Sher, and G. M. Shearer. 1996. Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus. J. Infect. Dis. 174:46.
22. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon y production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041.
23. Chomarat, P., M-C. Rissoan, J. Banchereau, and P. Miossec. 1993. Interferon γ inhibits interleukin 10 production by monocytes. J. Exp. Med. 177:523.
24. Trinchieri, G. 1995. Interleukin-12 and interferon-gamma. Do they always go together? Am. J. Pathol. 147:1534.
25. Chehimi, J., S. E. Starr, I. Frank, M. Rengaraju, S. J. Jackson, C. Lianes, M. Kobayashi, B. Perussia, D. Young, E. Nickbarg, S. F. Wolf, and G. Trinchieri. 1992. Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients. J. Exp. Med. 175:789.
26. Wright, S. C., A. Jewett, R. Mitsuyasu, and B. Bonavida. 1988. Spontaneous cytotoxicity and tumor necrosis factor production by peripheral blood monocytes from AIDS patients. J. Immunol. 141:99.
27. Breen, E. C., A. R. Rezai, K. Nakajima, G. N. Beall, R. T. Mitsuyasu, T. Hirano, T. Kishimoto, and O. Martinez-Maza. 1990. Infection with HIV is associated with elevated IL-6 levels and production. J. Immunol. 144:480.
28. Lathey, J. L., S. Kanangat, B. T. Rouse, J. M. Agosti, and S. A. Spector. 1994. Dysregulation of cytokine expression in monocytes from HIV-positive individuals. J. Leukocyte Biol. 56:347.
29. Bagasra, O., S. P. Hauptman, H. W. Lischner, M. Sachs, and R. J. Pomerantz. 1992. Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction. N. Engl. J. Med. 326:1385.
30. Lewis, D. E., M. Minshall, N. P. Wray, S. W. Paddock, L. C. Smith, and M. M. Crane. 1990. Confocal microscopic detection of human immunodeficiency virus RNA-producing cells. J. Infect. Dis. 162:1373.
31. CIerici, M., T. A. Wynn, J. A. Berzofsky, S. P. Blatt, C. W. Hendrix, A. Sher, R. L. Coffman, and G. M. Shearer. 1994. Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J. Clin. Invest. 93:768.
32. Lane, H. C., R. T. Davey, Jr., S. A. Sherwin, H. Masur, A. H. Rook, J. F. Manischewitz, G. V. Quinnan, P. D. Smith, M. E. Easter, and A. S. Fauci. 1989. A phase I trial of recombinant human interferon-gamma in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome (AIDS). J. Clin. Immunol. 9:351.
33. Heagy, W., J. Groopman, J. Schindler, and R. Finberg. 1990. Use of IFN-gamma in patients with AIDS. J. Acquired Immune Defic. Syndr. 3:584.