IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum

Journal of Immunology

Volumn 156, Issue 1, 1996, Pages 263-268

  Urban Jr , Joseph F ^a,d   Fayer, Ronald ^a   Chen, Shen Jue ^b   Gause, William C ^b   Gately, Maurice K ^c   Finkelman, Fred D ^b  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c HOFFMANN LA ROCHE INC   (United States)

^d AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; MESSENGER RNA; RECOMBINANT INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; GENE EXPRESSION; IMMUNOCOMPETENCE; INFECTION PREVENTION; INOCULATION; INTERFERON PRODUCTION; INTESTINE EPITHELIUM CELL; MOUSE; NEWBORN; NONHUMAN; OOCYST; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SPOROZOITE; SUBCUTANEOUS DRUG ADMINISTRATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANIMALS, NEWBORN; COCCIDIOSTATS; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; INTERFERON TYPE II; INTERLEUKIN-12; MICE; MICE, INBRED BALB C; MICE, SCID; SEVERE COMBINED IMMUNODEFICIENCY;

EID: 0030063209     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Fayer, R., and B L. P. Ungar. 1986. Cryptosporidium spp. and cryptosporidiosis. Microbiol. Rev. 50:458.
2. Fayer, R., C. A. Speer, and J. P Dubey. 1990. General biology of Cryptosporidium. In Cryptosporidiosis of Man and Animals. J. P. Dubey, C. A. Speer, and R. Fayer, eds CRC Press, Inc., Boca Raton, FL, p. 1.
3. Tzipori, S., W. Rand, J. Griffiths, G Widmer, and J Crabb. 1994. Evaluation of an animal model system for Cryptosporidiosis: therapeutic efficacy of paromomycin and hyperimmune bovine colostrum-immunoglobulin. Clin. Diagn. Lab. Immunol. 1:450.
4. Ungar, B. L. P., J. A. Burris, C A. Quinn, and F. D. Finkelman. 1990. New mouse models for chronic Cryptospordium infection in immunodeficient hosts. Infect Immun. 58:961.
5. Ungar, B. L. P., T. C. Kao, J. A. Burris, and F. D Finkelman. 1991. Cryptosporidium infection in an adult mouse model: independent roles for IFN-gamma and CD4 T lymphocytes in protective immunity. J. Immunol 147:1014.
6. Chen, W., J. A. Harp, and A. G. Harmsen. 1993. Requirements for CD4-positive cells and gamma interferon m resolution of established Cryptosporidium parvum infection in mice. Infect. Immun. 61:5932.
7. Harp, J. A., and W. M. Whitmire. 1991. Cryptosporidium parvum infection in mice: inability of lymphoid cells or culture supernatants to transfer protection from resistant adults to susceptible infants. J. Parasitol 77:170.
8. Manetti, R., P. Parronchi, M. G. Giudizi, M P Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 (IL-12)) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199.
9. + T-cells to enhance priming for IFN-gamma production and diminishes IL-4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
10. + T cells through IL-12-produced Listeria-induced macrophages. Science 260:547
11. Chan, S. H., B. Perussia, J. W Gupta, M. Kobayashi, M. Pospisil, H. A. Young, S. F. Wolf, D. Young, S. C. Clark, and G. Trinchieri. 1991. Induction of interferon-gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp Med. 173:869.
12. Kilani, R. T., and L. Sekla. 1987 Purification of Cryptosporidium oocysts and sporozoites by cesium chloride and Percoll gradients. Am J. Trop. Med. Hyg. 36:505.
13. Gately, M. K., R. R. Warrier, S. Honasoge, D. M. Carvajal, D. A. Faherty, S. E. Connaughton, T D. Anderson, U Sarmiento, B. R. Hubbard, and M. Murphy. 1994 Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo. Int. Immunol. 6:157.
14. Finkelman, F. D., I M. Katona, T. R Mossman, and R. L. Coffman. 1988. IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses. J. Immunol. 140:1022.
15. Tripp, C. S., M. K. Gately, J. Hakimik, P Ling, and E. R. Unanue. 1994. Neutralization of IL-12 decreases resistance to Listeria m SCID and C.B-17 mice: reversal by IFN-gamma. J. Immunol. 152:1883
16. Fayer, R., and W. Ellis. 1993. Glycoside antibiotics alone and combined with tetracyclines for prophylaxis of experimental cryptosporidiosis in neonatal BALB/c mice. J. Parasitol. 79:553.
17. Svetic, A., D. B. Madden, X. di Zhou, P. Lu, I. M. Katona, F. D. Finkelman, J F. Urban, Jr., and W. C. Gause. 1993. A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3. J. Immunol. 150:3434.
18. Morris, S. C., K. B. Madden, J J Adamovicz, W C, Gause, B R. Hubbard, M. K. Gately, and F. D. Finkelman. 1994. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J. Immunol. 152:1047
19. Gazzinelli, R. T., S. Hieny, T. A Wynn, S. Wolf, and A Sher. 1993. Interleukin-12 is required for the T-lymphocyte-independent induction of interferon-gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts Proc Natl Acad. Sci. USA 90:6115.
20. Urban, J F., Jr., K B Madden, A. Svetic, A. Cheever, P P Trotta, W. C. Gause, I. M. Katona, and F D. Finkelman. 1992 The importance of Th2 cytokines in protective immunity to nematodes. Immunol Rev 127:205.
21. Sedegah, M , F. D. Finkelman, and S L. Hoffman. 1994 Interleukin-12 induction of interferon-gamma-dependent protection against malaria. Proc. Natl. Acad Sci. USA 91:10700.
22. Colgan, S. P., C. A. Parkos, J B. Matthews, L. D'Andrea, C. S. Awtrey, A. H Lichtman, C. Delp, and J. L. Madara. 1994. Interferon-gamma induces a cell surface phenotype switch on T84 intestinal epithelial cells. Am J. Physiol. 267: 402.
23. Fayer, R., and S Baron. 1971. Activity of interferon and an inducer against development of Euneria tenella in cell culture. J. Protozool. 17(Suppl):12.
24. Rose, M. E., D. Wakelin, and P Hesketh 1989. Gamma interferon controls Eimeria vermiformis primary infection in BALB/c mice. Infect. Immun. 7:1599
25. Leitch, G. J., and Q. He. 1994. Arginine-derived nitric oxide reduces fecal oocyst shedding in nude mice infected with Cryptosporidium parvum. Infect Immun 62:5173.
26. James, S. L., and J. A. Glaven 1989. Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. J. Immunol. 143:4208
27. Fitchenbaum, C. J., D. J Ritchie, and W G. Powderly. 1993. Use of paromomycin for treatment of cryptosporidiosis in patients with AIDS. Clin. Infect. Dis 16:298.
28. Ungar, B L. P , D J. Ward, R. Fayer, and C. A Quinn. 1990. Cessation of Cryptosproidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum Gastroenterology 98 486.
29. Nabors, G. S., L. C C Afonso, J P. Farrell, and P. Scott. 1995. Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin-12 and Penstostam. Proc. Natl. Acad. Sci. USA 92:3142.
30. Clemons, K. V., E. Brummer, and D. A. Stevens. 1994. Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and in synergy with conventional antifungal therapy in experimental cryptococcosis. Antimicrob. Agents Chemother. 38:460.
31. Scharton-Kersten, T , and P Scott. 1995 The role of the innate immune response in Th1 development following Leishmania major infection. J. Leukocyte Biol. 57:515.
32. Harp, J. A., D. B. Woodmansee, and H. W. Moon. 1990. Resistance of calves to Cryptosporidium parvum. effects of age and previous exposure. Infect Immun. 58:2237