Characterization of early IL-12, IFN-αβ, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection

Journal of Immunology

Volumn 156, Issue 12, 1996, Pages 4746-4756

  Orange, Jordan S ^a   Biron, Christine A ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; INTERLEUKIN 12; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ARTICLE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; IMMUNOSTIMULATION; INFECTION RESISTANCE; INTERFERON PRODUCTION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS INHIBITION;

ANIMALS; CYTOMEGALOVIRUS INFECTIONS; CYTOTOXICITY, IMMUNOLOGIC; DRUG ADMINISTRATION SCHEDULE; HERPESVIRIDAE INFECTIONS; IMMUNITY, CELLULAR; INTERFERON TYPE I; INTERLEUKIN-12; KILLER CELLS, NATURAL; MALE; MICE; MICE, INBRED C57BL; MICE, NUDE; MICE, SCID; MUROMEGALOVIRUS; T-LYMPHOCYTES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029929032     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Reynolds, R. P., R. J. Rahija, D. I. Schenkman, and C. B. Richter. 1993. Experimental murine cytomegalovirus infection in severe combined immunodeficient mice. Lab. Anim. Sci. 43:291.
2. Messerle, M., G. M. Keil, K. Schneider, and U. H. Koszinowski. 1992. Characterization of the murine cytomegalovirus genes encoding the major DNA binding protein and the ICP18.5 homolog. Virology 191:355.
3. Smith, M. A., and D. J. Brennessel. 1994. Cytomegalovirus. Infect. Dis. Clin. North Am. 8:427.
4. Martinotti, M. G., M. Gariglio, F. Cofano, G. Cavallo, and S. Landolfo. 1990. The role of interferons in the resistance to murine cytomegalovirus. Microbiologica 13:305.
5. Gribaudo, G., S. Ravaglia, A. Caliendo, R. Cavallo, M. Gariglio, M. G. Martinotti, and S. Landolfo. 1993. Interferons inhibit onset of murine cytomegalovirus immediate-early gene transcription. Virology 197:303.
6. Martinotti, M. G., G. Gribaudo, M. Gariglio, A. Caliendo, D. Lembo, A. Angeretti, R. Cavallo, and S. Landolfo. 1993. Effect of interferon-α on immediate early gene expression of murine cytomegalovirus. J. Interferon Res. 13:105.
7. Schut, R. L., G. Gekker, S. Hu, C. C. Chao, C. Pomeroy, M. C. Jordan, and P. K. Peterson. 1994. Cytomegalovirus replication in murine microglial cell cultures: suppression of permissive infection by interferon-γ. J. Infect. Dis. 169:1092.
8. Lucin, P., S. Jonjic, M. Messerle, B. Polic, H. Hengel, and U. H. Koszinowski. 1994. Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor. J. Gen. Virol. 75:101.
9. Van Der Meer, J. W. M., R. H. Rubin, M. Pasternack, D. N. Medearis, P. Lynch, and C. A. Dinarello. 1989. The in vivo and in vitro effects of interleukin-1 and tumor necrosis factor on murine cytomegalovirus infection. Biotherapy 1:227.
10. Grundy (Chalmer), J. E., J. Trapman, J. E. Allan, G. R. Shellam, and C. J. M. Melier. 1982. Evidence for a protective role of interferon in resistance to murine cytomegalovirus and its control by non-H-2-linked genes. Infect. Immun. 37:143.
11. Chong, K. T., I. Gresser, and C. A. Mims. 1983. Interferon as a defense mechanism in mouse cytomegalovirus infection. J. Gen. Virol. 64:461.
12. Lucin, P., I. Pavic, B. Polic, S. Jonjic, and U. H. Koszinowski. 1992. Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands. J. Virol. 66:1977.
13. Orange, J. S., B. Wang, C. Terhorst, and C. A. Biron. 1995. Requirement for natural killer cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J. Exp. Med 182:1045.
14. Pavic, I., B. Polic, I. Crnkovic, P. Lucin, S. Jonjic, and U. H. Koszinowski. 1993. Participation of endogenous tumour necrosis factor α in host resistance to cytomegalovirus infection. J. Gen. Virol. 74:2215.
15. Gidlund, M., A. Orn, H. Wigzell, A. Senik, and I. Gresser. 1978. Enhanced NK cell activity in mice injected with interferon and interferon inducers. Nature 273: 759.
16. Bukowski, J. F., B. A. Woda, and R. M. Welsh. 1984. Pathogenesis of murine cytomegalovirus infection in natural killer cell-depleted mice. J. Virol. 52:119.
17. Welsh, R. M., J. O. Brubaker, M. Vargas-Cortes, and C. L. O'Donnell. 1991. Natural killer (NK) cell response to virus infections in mice with severe combined immunodeficiency: the stimulation of NK cells and the NK cell-dependent control of virus infections occur independently of T and B cell function. J. Exp. Med. 173:1053.
18. Biron, C. A., and R. M. Welsh. 1982. Blastogenesis of natural killer cells during viral infection in vivo. J. Immunol. 129:2788.
19. Biron, C. A., G. Sonnenfeld, and R. M. Welsh. 1984. Interferon induces natural killer cell blastogenesis in vivo. J. Leukocyte Biol. 35:31.
20. Kasaian, M. T., and C. A. Biron. 1990. Cyclosporin A inhibition of interleukin 2 gene expression, but not natural killer cell proliferation, after interferon induction in vivo. J. Exp. Med. 171:745.
21. Ishikawa, R., and C. A. Biron. 1993. IFN induction and associated changes in splenic leukocyte distribution. J. Immunol. 150:3713.
22. Biron, C. A., H. C. Su, and J. S. Orange. 1996. Function and regulation of natural killer cells during viral infections: characterization of responses in vivo. Methods: Suppl. Methods Enzymol. 9:In press.
23. Biron, C. A., and J. S. Orange. 1995. IL-12 in acute viral infectious disease. Res. Immunol. 146:590.
24. Orange, J. S., and C. A. Biron. 1996. An absolute and restricted requirement for interleukin-12 in natural killer (NK) cell interferon-γ production and antiviral defense: studies of NK and T cell responses in contrasting viral infections. J. Immunol. 156:1138.
25. Wang, B., C. Biron, J. She, K. Higgins, M.-J. Sunshine, E. Lacy, N. Lonberg, and C. Terhorst. 1994. A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3ε gene. Proc. Natl. Acad. Sci. USA 91:9402.
26. Walsh, C. M., M. Matloubian, C.-C. Liu, R. Ueda, C. G. Kurahara, J. L. Christense, M. T. F. Huang, J. D.-E. Young, R. Ahmed, and W. R. Clark. 1994. Immune function in mice lacking the perform gene. Proc. Natl. Acad. Sci. USA 91:10854.
27. Kagi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K. J. Olsen, E. R. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31.
28. Wysocka, M., M. Kubin, L. Q. Vieira, L. Ozmen, G. Garotta, P. Scott, and G. Trinchieri. 1995. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:672.
29. Gresser, I., M. G. Tovey, M.-T. Bandu, C. Maury, and D. Broty-Boye. 1976. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. J. Exp. Med. 144:1305.
30. Suitters, A. J., R. Foulkes, S. M. Opal, J. E. Palardy, J. S. Emtage, M. Rolfe, S. Stephens, A. Morgan, A. R. Holt, L. C. Chaplin, N. E. Shaw, A. M. Nesbitt, and M. W. Bodmer. 1994. Differential effect of isotype on efficacy of anti-tumor necrosis factor αa chimeric antibodies in experimental septic shock. J. Exp. Med. 179:849.
31. Williams, J. G., G. J. Jurkovich, G. B. Hahnel, and R. V. Maier. 1992. Macrophage priming by interferon gamma: a selective process with potentially harmful effects. J. Leukocyte Biol. 52:579.
32. Orange, J. S., T. P. Salazar-Mather, S. M. Opal, R. L. Spencer, A. H. Miller, B. S. McEwen, and C. A. Biron. 1995. Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids. J. Exp. Med. 181:901.
33. 2-microglobulin-deficient mice. J. Immunol. 155:5674.
34. Biron, C. A., H. A. Young, and M. T. Kasaian. 1990. Interleukin 2-induced proliferation of murine natural killer cells in vivo. J. Exp. Med. 171:173.
35. Selgrade, M. J. K., and J. E. Osborn. 1974. Role of macrophages in resistance to murine cytomegalovirus. Infect. Immun. 10:1383.
36. Heise, M. T., and H. W. I. Virgin. 1995. The T-cell-independent role of gamma interferon and tumor necrosis factor alpha in macrophage activation during murine cytomegalovirus and herpes simplex virus infections. J. Virol. 69:904.
37. + NK cells. J. Immunol. 148:2429.
38. + natural killer cells stimulated with imerleukin-2, interleukin-7 and interleukin-12. Eur. J. Immunol. 23:1831.
39. Chan, S. H., M. Kobayashi, D. Santoli, B. Perussia, and G. Trinchieri. 1992. Mechanisms of IFN-γ induction by natural killer cell stimulatory factor (NKSF/IL-12). J. Immunol. 148:92.
40. Chan, S. H., B. Perussia, J. W. Gupta, M. Kobayashi, M. Pospisil, H. A. Young, S. F. Wolf, D. Young, S. C. Clark, and G. Trinchieri. 1991. Induction of interferon γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173:869.
41. Kubin, M., J. M. Chow, and G. Trinchieri. 1994. Differential regulation of interleukin-12 (IL-12), tumor necrosis factor α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood 83: 1847.
42. Skeiky, A. W., J. A. Guderian, D. R. Benson, O. Bacelar, E. M. Carvalho, M. Kubin, R. Badaro, G. Trinchieri, and S. G. Reed. 1995. A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12. J. Exp. Med. 181:1527.
43. Chensue, S. W., J. H. Ruth, K. Warmington, P. Lincoln, and S. L. Kunkel. 1995. In vivo regulation of macrophage IL-12 production during type 1 and type 2 cytokine-mediated granuloma formation. J. Immunol. 155:3546.
44. Flesch, I. E. A., J. H. Hess, S. Huang, M. Aguet, J. Rothe, H. Bluethmann, and S. H. E. Kaufmann. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α. J. Exp. Med. 181:1615.
45. Scharton-Kersten, T., L. C. C. Afonso, M. Wysocka, G. Trinchieri, and P. Scott. 1995. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154:5320.
46. Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725.
47. Gazzineli, R. T., S. Hieny, T. Wynn, S. Wolf, and A. Sher. 1993. IL-12 is required for T-cell independent induction of IFN-γ by an intracellular parasite and induces resistance in T-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115.
48. Hunter, C. A., C. S. Subauste, V. H. Van Cleave, and J. S. Remington. 1994. Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SClD mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infect. Immun. 62:2818.
49. Ando, K., L. G. Guidotti, A. Cerny, T. Ishidawa, and F. V. Chisari. 1994. CTL access to tissue antigen is restricted in vivo. J. Immunol. 153:482.
50. Guidotti, L. G., K. Ando, M. V. Hobbs, T. Ishidawa, L. Runkel, R. D. Schreiber, and F. V. Chisari. 1994. Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc. Natl. Acad. Sci. USA 91:3764.