IL-12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans

Clinical and Experimental Immunology

Volumn 104, Issue 2, 1996, Pages 208-214

  Kawakami, K ^a   Tohyama, M ^a   Xie, Q ^a   Saito, A ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Dissemination; IFN ; IL 12; Pulmonary cryptococcosis

Indexed keywords

GAMMA INTERFERON; MESSENGER RNA; RECOMBINANT INTERLEUKIN 12;

ANIMAL EXPERIMENT; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; FEMALE; HOST RESISTANCE; INTRAPERITONEAL DRUG ADMINISTRATION; MENINGITIS; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL;

EID: 0029981459     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.14723.x     Document Type: Article

References (35)

1. D'Andrea A, Rengaraju M, Valiante NM et al. Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J Exp Med 1992; 176;1387-98.
2. Chan SH, Perussia B, Gupta JW et al. Induction of IFN-γ production by NK cell stimulatory factor (NKSF): characterization of the responder cells and synergy with other inducers. J Exp Med 1991; 173:869-79.
3. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995; 13:251-76.
4. + T cells occurs through macrophage production of IL-12. Science 1993; 260:547-9.
5. + T cells to enhance priming for IFN-γ production and diminishes IL-4 inhibition of such priming. Proc Natl Acad Sci USA 1993; 90:10188-92.
6. Gazzinelli RT, Wysocka M, Hayashi S et al. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol 1994; 153:2533-43.
7. Heinzel FP, Schoenhaut DS, Rerko RM, Rosser LE, Gately MK. Recombinant interleukin 12 cures mice infected with Leishmania major. J Exp Med 1993; 177:1505-9.
8. Romani L, Mencacci A, Tonnetti L et al. IL-12 is both required and prognostic in viva for T helper type I differentiation in murine candidiasis. J Immunol 1994; 152:5167-75.
9. Tripp CS, Gately MK, Hakimi J, Ling P, Unanue ER. Neutralization of IL-12 decreases resistance to Listeria in SCID and CB-17 mice. J Immunol 1994; 152:1883-7.
10. Stevens DA. Fungal infections in AIDS patients. Br J Clin Practice 1990; 44(Suppl. 1):11-22.
11. Lim TS, Murphy JW. Transfer of immunity to cryptococcosis by T-enriched splenic lymphocytes from Cryptococcus neoformans-sensitized mice. Infect Immun 1980; 30:5-11.
12. + T cells. J Exp Med 1991; 173:755-8.
13. +) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans. J Immunol 1990; 1144:1472-7.
14. Kawakami K, Kohno S, Kadota J et al. T cell-dependent activation of macrophages and enhancement of their phagocytic activity in the lungs of mice inoculated with heat-killed Cryptococcus neoformans: involvement of IFN-γ and its protective effect against cryptococcal infection. Microbiol Immunol 1995; 39:135-43.
15. Salkowski CA, Balish E. A monoclonal antibody to gamma interferon blocks augmentation of natural killer cell activity induced during systemic cryptococcosis. Infect Immun 1991; 59:486-93.
16. Clemons KV, Brummer E, Stevens DA. Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis. Antimicrob Agents Chemother 1994; 38:460-4.
17. Kozel TR. Cryptococcosis. In: Murphy JW, Friedman H, Bendinelli M, eds. Fungal infection and immune responses. New York: Plenum Press, 1993:277-302.
18. Brummer E, Stevens D. Anticryptococcal activity of macrophages: role of mouse strain, C5, contact, and L-arginine. Cell Immunol 1994; 157:1-10.
19. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156-9.
20. Montgomery RA, Dallman MJ. Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction. J Immunol 1991; 147:554-60.
21. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170:2081-95.
22. Peleman R, Wu J, Fargeas C, Delespesse G. Recombinant interleukin 4 suppresses the production of interferon γ by human mononuclear cells. J Exp Med 1989; 170:1751-6.
23. Sher A, Gazzinelli RT, Oswald IP et al. Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunol Rev 1992; 127:183-204.
24. Bretscher PA, Wei G, Menon JN, Bielefeldt-Ohmann H. Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science 1992; 257:539-42.
25. Burstein HJ, Abbas AK. In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen. J Exp Med 1993; 177:457-63.
26. Nabors GS, Afonso LCC, Farrell JP, Scott P. Switch from a type 2 to a type I T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. Proc Natl Acad Sci USA 1995; 92:3142-6.
27. Rabinowich H, Herberman RB, Whiteside TL. Differential effects of IL-12 and IL-12 on expression and function of cellular adhesion molecules of purified human natural killer cells. Cell Immunol 1993; 152:481-98.
28. Sica A, Wang JM, Colotta et al. Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor. J Immunol 1990; 144:3034-8.
29. Springer TA. Adhesion receptors of the immune system. Nature 1990; 346:425-34.
30. Strieter RM, Kunkel SL, Showell HJ, Marks RM. Endothelial cell gene expression of a neutrophil chemotactic factor by TNF, IL-1 and LPS. Science 1989; 243:1467-9.
31. Green SJ, Turpin JA, Nacy CA. Cytotoxic effector activities of macrophages. In: Rich RR, Fleisher TA, Schwanz BD, Shearer WT, Strober W, eds. Clinical immunology: principles and practice. St Louis: Mosby-Year Book, Inc., 1996:290-8.
32. Yoshimura T, Matsushima K, Tanaka S, Robinson EA, Appella E, Oppenheim JJ, Leonard EJ. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci USA 1987; 84:9233-7.
33. Colotta F, Borre A, Wang JM et al. Expression of a monocyte chemotactic cytokine by human mononuclear phagocytes. J Immunol 1991; 148:760-5.
34. Vecchiarelli A, Retini C, Pietrella D, Monari C, Tascini C, Beccari T, Kozel TR. Downregulation by cryptococcal polysaccharide of tumor necrosis factor alpha and interleukin-1β secretion from human monocytes. Infect Immun 1995; 63:2919-23.
35. Ramilo O, Saez-Llorens Z, Mertsola J et al. Tumor necrosis factor α/cached in and interleukin β initiate meningeal inflammation. J Exp Med 1990; 172:497-507.