Interleukin-12 restores interferon-γ production and cytotoxic responses in visceral leishmaniasis

Journal of Infectious Diseases

Volumn 173, Issue 6, 1996, Pages 1515-1518

  Bacellar, Olivia ^b   Brodskyn, Claudia ^b   Guerreiro, Jaqueline ^b   Barral Netto, Manoel ^b   Costa, Carlos Henrique ^b   Coffman, Robert L ^b   Johnson, Warren D ^b   Carvalho, Edgar M ^a  

^a FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12;

ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEISHMANIA; LYMPHOCYTE PROLIFERATION; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE; VISCERAL LEISHMANIASIS;

EID: 0029840157     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/173.6.1515     Document Type: Article

References (15)

1. Reiner NE, Ng W, Ma T, McMaster WR. Kinetics of Interferon binding and induction of major histocompatibility complex class II mRNA in Leishmania-infected macrophages. Proc Natl Acad Sci USA 1988; 85: 4330-4.
2. Ghalib HW, Whittle JA, Kubin M, et al. IL-12 enhances Thl-type responses in human Leishmania donovani infections. J Immunol 1995; 154:4623-9.
3. Carvalho EM, Badaró R, Reed SG, Jones TC, Johnson Jr WD. Absence of gamma interferon and interleukin-2 production during active visceral leishmaniasis. J Clin Invest 1985; 76:2066-9.
4. Harms G, Pedrosa C, Omena S, Feldmeier H, Zwingenberger K. Natural killer cell activity in visceral leishmaniasis. Trans R Soc Trop Med Hyg 1991; 85:54-5.
5. Ghalib HW, Piuvezam MR, Skeiky YA, et al. Interleukin-10 production correlates with pathology in human Leishmania donovani infections. J Clin Invest 1993;92:324-9.
6. Carvalho EM, Barrai A, Pedral-Sampaio D, et al. Immunologic markers of clinical evolution in children recently infected with Leishmania donovani chagasi. J Infect Dis 1992; 165:535-40.
7. Carvalho EM, Bacellar O, Brownell C, Régis T, Coffman RL, Reed SG. Restoration of IFN-γ production and lymphocyte proliferation in visceral leishmaniasis. J Immunol 1994; 152:5949-56.
8. Carvalho EM, Bacellar O, Reed S, Barrai A, Rocha H. Visceral leishmaniasis: a disease associated with inability of lymphocytes to activate macro-phages to kill leishmania. Braz J Med Biol Res 1988;21:85-92.
9. Chehimi J, Starr SE, Frank I, et al. Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus - infected patients. J Exp Med 1992; 175:789-96.
10. Manetti R, Parronchi P, Guidizi MG, et al. Natural killer cell stimulatory factor (interleukin-12 [IL-12]) induces T helper type 1 (Thl)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 1993; 177:1199-204.
11. + T cells in resistance to cutaneous leishmaniasis in immunized mice. J Immunol 1989; 142: 2052-6.
12. Salcedo TW, Azzoni L, Wolf SF, Perussia B. Modulation of perform and granzyme messenger RNA expression in human natural killer cells. J Immunol 1993; 151:2511-20.
13. D' Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G. Interleukin-10 (IL-10) inhibits human lymphocyte interferon-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993;178:1041-8.
14. Murray HW, Harisprashad J. Interleukin-12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis. J Exp Med 1995; 181:387-91.
15. Badaró R, Johnson, WD. The role of interferon-γ in the treatment of visceral and diffuse cutaneous leishmaniasis. J Infect Dis 1993; 167(suppl):S13-7.