IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response

Journal of Immunology

Volumn 156, Issue 3, 1996, Pages 887-894

  Bliss, Judy ^a   Van Cleave, Victor ^a   Murray, Kristin ^a   Wiencis, Anna ^a   Ketchum, Mara ^a   Maylor, Richard ^a   Haire, Teresa ^a   Resmini, Christine ^a   Abbas, Abul K ^b   Wolf, Stanley F ^a  

^a PFIZER INC   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; KEYHOLE LIMPET HEMOCYANIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE EXPRESSION; HELPER CELL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOASSAY; INTERFERON PRODUCTION; MEMORY CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLEEN CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODY SPECIFICITY; FEMALE; HEMOCYANIN; IMMUNOGLOBULIN G; IMMUNOLOGIC MEMORY; INTERLEUKIN-12; INTERLEUKIN-4; LYMPH NODES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLLUSCA; SPLEEN; TH1 CELLS; TH2 CELLS; TRINITROBENZENES;

EID: 9044227258     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Afonso, L. C. C., T M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of IL-12 in a vaccine against Leishmania major. Science 263:235.
2. Noguchi, Y , E. C Richards, Y.-T. Chen, and L. J. Old 1995. Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma Proc. Natl. Acad. Sci. USA 92:2219.
3. Finkelman, F. D., J. Holmes, I. M. Katona, J. F. J. Urban, M. P. Beckmann, L. S. Park, K. A. Schooley, R. L. Coffman, T. R. Mosmann, and W. E Paul. 1990 Lymphokine control of in vivo immunoglobulin isotype selection Annu. Rev. Immunol. 8:303.
4. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
5. + T cells to enhance priming for interferon γ production and diminishes interleukin-4 inhibition of such priming. Proc Natl. Acad Sci USA 1990:10188.
6. McKnight, A. J., G. J. Zimmer, I. Fogelman, S F. Wolf, and A. K. Abbas. 1994. Effects of IL-12 on helper T cell-dependent immune responses in vivo. J. Immunol. 152:2172.
7. Sypek, J. P., C. L. Chung, S. E. H. Mayor, J M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F Wolf, and R G. Schaub. 1993 Resolution of cutaneous leishmaniasis: interleukin-12 initiates a protective T helper type 1 immune response J. Exp. Med. 177:1797.
8. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant IL12 cures mice infected with Leishmania major. J. Exp. Med 177:1505.
9. Perez, V. L., J. A Lederer, A. H Lichtman, and A. K. Abbas. 1995. Stability of Th1 and Th2 populations. Int. Immunol. 7:869.
10. Swain, S. L., A D. Weinberg, M. English, and G. Huston. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145:3796.
11. Germann, T., M. Bongartz, H. Dlugonska, H. Hess, E. Schmitt, L. Kolbe, E. Kolsch, F. J. Podlaski, M. K. Gately, and E. Rude. 1995. Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo. Eur. J. Immunol. 25:823.
12. Finkelman, F. D., K B. Madden, A. W. Cheever, I. M Katona, S. C. Morris, M. K. Gately, B. R. Hubbard, W. C Cause, and J. F. Urban, Jr. 1994 Effects of interleukin-12 on immune responses and host protection in mice infected with intestinal nematode parasites. J Exp. Med. 179:1563
13. Bradley, L. M., M. Croft, and S. L. Swain. 1993. T-cell memory: new perspectives. Immunol. Today 14:197.
14. Swain, S. L. 1994. Generation and in vivo persistence of polarized Th1 and Th2 memory. Immunity 1:543.
15. Szabo, S. J., N. G. Jacobson, A. S. Dighe, U. Gubler, and K. M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2:665.
16. Wynn, T. A., D Jankovic, S. Hieny, A. W. Cheever, and A Sher. 1995. IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice while decreasing Th2 cytokine expression, IgE production, and tissue eosinophiha. J. Immunol. 154:4701.
17. Burstein, H. J., R. I. Tepper, P. Leder, and A. K. Abbas 1991. Humoral immune functions in IL-4 transgenic mice. J. Immunol. 147:2950.
18. Gately, M. K., R R. Warrier, S. Honasoge, D. M. Carvajal, D. A. Gaherty, S. E. Connaughton, T. D. Anderson, U. Sarmiento, B. R. Hubbard, and M. Murphy. 1994. Administration of recombinant EL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo. Int. Immunol. 1:157.
19. Gately, M. K., and R. Chizzonite. 1993. Measurement of human and mouse interleukin 12. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. John Wiley & Sons, New York, pp. 6.16.3-6.16.8.
20. Hu-Li, J., J. Ohara, C. Watson, W. Tsang, and W. E. Paul. 1989. Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S). J. Immunol. 142:800.
21. Burstein, H. J., and A K. Abbas. 1993. In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen. J Exp. Med. 177.457.
22. Bradley, L. M., D. D. Duncan, K. Yoshimoto, and S. L. Swain. 1993. Memory effectors: a potent, IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen. J. Immunol. 150:3119.
23. Manetti, R., F. Gerosa, M. G. Giudici, R Biagiotti, P. Parronchi, M-P Piccinni, S. Sampognaro, E Maggi, S. Romagnani, and G. Trinchieri. 1994 IL12 induces stable pruning for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J Exp. Med. 179:1273
24. + T cells. Eur. J Immunol. 24:343.
25. Jeannin, P., Y. Delneste, P. Life, J.-F. Gauchat, D. Kaiserlian, and J.-Y. Bounegoy. 1995. Interleukin-12 increases interleukin-4 production by established human Th0 and Th2-like T cell clones. Eur. J. Immunol. 25:2247.
26. Wynn, T. A , D Jankovic, S Hieny, K. Zioncheck, P. Jardieu, A. W. Cheever, and A. Sher 1995. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ. J. Immunol. 154:3999.
27. Wu, C. Y., C. E Demeure, M. Gately, F. Podlaski, H Yssel, M, Kiniwa, and G. Delespesse. 1994. In vitro maturation of human neonatal CD4 T lymphocytes. J. Immunol 152:1141.
28. Laskay, T., A. Diefenbach, M. Rollinghoff, and W Solbach. 1995. Early parasite containment is decisive for resistance to Leishmania major infection. Eur. J. Immunol 25:2220.
29. Scott, P. 1991. IFN-γ modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol. 147:3149.
30. Trinchieri, G. 1994. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008
31. Kubin, M., M. Kamoun, and G. Trinchieri 1994. IL12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J Exp. Med 180:211.