Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus

Journal of Infectious Diseases

Volumn 174, Issue 1, 1996, Pages 46-53

  Chougnet, Claire ^a   Wynn, Thomas A ^b   Clerici, Mario ^b   Landay, Alan L ^b   Kessler, Harold A ^b   Rusnak, Janice ^b   Melcher, Gregory P ^b   Sher, Alan ^b   Shearer, Gene M ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; MESSENGER RNA;

ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREGULATION; MACROPHAGE; MAJOR CLINICAL STUDY; MONOCYTE; PRIORITY JOURNAL;

EID: 0030055867     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/174.1.46     Document Type: Article

References (19)

1. Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1994;84:4008-27.
2. D'Andrea A, Rengaraju M, Valiante NM, et al. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 1992;176:1387-98.
3. Stern AS, Podlaski FJ, Hulmes JD, et al. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci USA 1990;87: 6808-12.
4. Clerici M, Shearer GM. A TH1 - TH2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993;14:107-11.
5. Clerici M, Wynn TA, Berzofsky JA, et al. Role of interleukin-10 in T cell helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest 1994;93:768-75.
6. Clerici M, Lucey DR, Berzofsky JA, et al. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 1993;262:1721-4.
7. Clerici M, Sarin A, Coffman RL, et al. Type I/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis. Proc Natl Acad Sci USA 1994;91:11811-5.
8. Radrizzani M, Accomero P, Amidei A, et al. IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation. Cell Immunol 1995;161:14-21.
9. Chehimi J, Starr SE, Frank I, et al. Impaired IL-12 production in human immunodeficiency virus-infected patients. J Exp Med 1994;179:1361-6.
10. Denis, M, Ghadirian E. Dysregulation of interleukin-8, interleukin-10, and interleukin-12 release by alveolar macrophages from HIV type 1-infected subjects. AIDS Res Hum Retroviruses 1994;10:1619-27.
11. Gazzinelli RT, Bala S, Stevens R, et al. HIV infection suppresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokines. J Immunol 1995;155:1565-74.
12. Clerici M, Hakim FT, Venzon DJ, et al. Changes in interleukin-2 and interleukin-4 production in asymptomatic HIV-seropositive individuals. J Clin Invest 1993;91:759-65.
13. Karp CL, El-Safi SH, Wynn TA, et al. In vivo cytokine profiles in patients with kala-azar. Marked elevations of both IL-10 and IFN-γ. J Clin Invest 1993;91:1644-8.
14. Foli A, Saville MW, Baseler MW, Yarchoan R. Effects of the Th1 and Th2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication. Blood 1995;85:2114-23.
15. Wahl SM, McCartney FN, Hunt DA, Smith PD, Wahl LM, Katona IM. Monocyte interleukin-2 receptor/gene expression and interleukin-2 augmentation of microbicidal activity. J Immunol 1987;139:1342-7.
16. Emilie R, Fior R, Crevon MC, Maillot MC, Boue F, Galanaud P. Cytokines from lymphoid organs of HIV-infected patients: production and role in the immune disequilibrium of the disease. Res Immunol 1994;145:595-602.
17. Masood R, Lunardi-Iskandar Y, Moudgil T, et al. IL-10 inhibits HIV-1 replication and is induced by Tat. Biochem Biophys Res Commun 1994; 202:374-83.
18. Murphy TL, Cleveland MG, Kulesza P, Magram J, Murphy KM. Regulation of interleukin-12 p40 expression through an NF-kappa B half-site. Mol Cell Biol 1995;15:5258-67.
19. Shu U, Kiniwa M, Wu CY, et al. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur J Immunol 1995;25:1125-8.