Multiple host defense defects in failure of C57BL/6 ep/ep (pale ear) mice to resolve visceral Leishmania donovani infection

Infection and Immunity

Volumn 64, Issue 1, 1996, Pages 161-166

  Murray, Henry W ^a   Hariprashad, June ^a   Mcdermott, David F ^a,b   Stoeckle, Mark Y ^a  

^a Department of Obstetrics Gynecology   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMONY; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GRANULOMATOUS INFLAMMATION; HELPER CELL; HOST RESISTANCE; IMMUNE DEFICIENCY; LEISHMANIA DONOVANI; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VISCERAL LEISHMANIASIS;

EID: 0030048115     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.1.161-166.1996     Document Type: Article

References (28)

1. Afonso, L., and P. Scott. 1993. Immune response associated with susceptibility of C57BL/10 mice to Leishmania amazonensis. Infect. Immun. 61:2952-2959.
2. Brown, J. A., E. K. Novak, and R. T. Swank. 1985. Effects of ammonia on processing and secretion of precursor and mature lysosomal enzyme from macrophages of normal and pale ear mice: evidence for two distinct pathways. J. Cell Biol. 100:1894-1904.
3. Cervia, J., H. Rosen, and H. W. Murray. 1993. Effector role of blood monocytes in experimental visceral leishmaniasis. Infect. Immun 61:1330-1333.
4. Change, K.-P., and D. M. Dwyer. 1978. Leishminia donovani: hamster macrophage interactions in vitro: cell entry, intracellular survival, and multiplication of amastigotes. J. Exp. Med. 147:515-528.
5. Chatelain, R., K. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol 148:1182-1187.
6. - T cell subsets in vivo. Immunol. Rev. 123:190-207.
7. Crocker, P. R., J. M. Blackwell, and D. J. Bradley. 1984 Expression of the natural resistance gene Lsh in resident liver macrophages. Infect. Immun. 43:1033-1040.
8. Freedman, V. H., M. Meisler, D. Lepay, W. A. Scott, and S. C. Silverstein. 1984. Failure to elicit activated macrophages in light and pale car mutant mice after treatment with BCG Fed. Proc. 43:1800. (Abstract.)
9. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of Interferon-γ or interleukin-4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T cell subsets J. Exp. Med. 169:59-72.
10. + lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl. Acad Sci. USA 88:7011-7015.
11. Howard, M., and A. O'Garra. 1992. Biological properties of interleukin-10. immunol. Today 13:198-200.
12. Miralles, G. D., M. Y. Stoeckle, D. F. McDerraott, F. D. Finkelman, and H. W. Murray. 1994. Induction of Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis. Infect. Immun 62:1058-1063.
13. Morris, L., A. Troutt, A. Kelson, E. Handman, and T. Aebischer. 1993. Interleukin-4 but not gamma interferon production correlates with seventy of murine cutaneous leishmaniasis. Infect. Immun. 61:3459-3465.
14. Murray, H. W. 1990. Effect of continuous administration of interferon-γ in experimental visceral leishmaniasis. J. Infect Dis. 161:992-994.
15. Murray, H. W., J. S. Cervia, J. Hariprashad, A. P. Taylor, M. Y. Stoeckle, and H. Hochman. 1995. Effect of granulocyte-macrophage colony-stimulating factor in experimental visceral leishmaniasis. J. Clin. Invest 95:1183-1189.
16. Murray, H. W., and J. Hariprashad. 1995 Interleukin-12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis. J Exp. Med. 181:387-391.
17. Murray, H. W., J. Hariprashad, B. Aguero, T. Arakawa, and H. Yeganegi. 1995. Intracellular antimicrobial response of the T cell-deficient host to cytokine therapy effect of interferon-γ in experimental visceral leishmaniasis in nude mice. J. Infect. Dis 171:1309-1313.
18. Murray, H. W., J. Hariprashad, and R. Fictl. 1993 Treatment of experimental visceral leishmaniasis in a T-cell-deficient host: response to amphotericin B and pentamidine Antimicrob. Agents Chemother. 37:1504-1505.
19. Murray, H. W., G. D. Miralles, M. Y. Stoeckle, and D. F. McDermott. 1993. Role and effect of interleukin-2 in experimental visceral leishmaniasis. J Immunol. 151:929-934.
20. Murray, H. W., L. Oca, A. M. Granger, and R. D. Schreiber. 1989. Successful response to chemotherapy in experimental visceral leishmaniasis: requirement for T cells and effect of lymphokines. J. Clin Invest. 83:1253-1255
21. Murray, H. W., J. J. Stern, K. Welte, B. Y. Rubin, S. M. Carriero, and C. F. Nathan. 1987. Experimental visceral leishmaniasis: production of interleukin-2 and interferon-γ, tissue immune reactions, and response to treatment with interleukin-2 and interferon-γ. J. Immunol. 138:2290-2290.
22. Orn, A., E. M. Hakansson, M. Gidlund, U. Ramstedt, I. Axberg, and L. G. Lundin. 1982. Pigment mutations in the mouse which also affect lysosomal functions lead to suppressed natural killer cell activity. Scand. J. Immunol. 15:305-310.
23. + cells during initiation of infection. J. Exp. Med. 179:447-456.
24. Sadick, M. D., F. P. Heinzel, B. J. Holaday, R. T. Pu, R. S. Dawkins, and R. M. Locksley. 1990 Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody: evidence for a T cell-dependent, interferon-γ-independent mechanism. J. Exp Med. 171:115-127
25. Squires, K. E., M. Kirsch, S. C. Silverstein, A. Acosta, J. J. McElrath, and H. W. Murray. 1990. Defect in the tissue immune response: experimental visceral leishmaniasis in euthymic C57B1/6 ep/ep mice. Infect. Immun 58:3893-3898.
26. Squires, K. E., R. D. Schreiber, M. J. McElrath, B. Y. Rubin, S. L. Anderson, and H. W. Murray. 1989. Experimental visceral leishmaniasis: role of endogenous IFN-γ in host defense and tissue granulomatous response. J. Immunol. 143:4244-4249.
27. + cells in experimental visceral leishmaniasis. J. Immunol. 140:3971-3975.
28. Tumang, M., C. Keogh, L. Moldawer, D. Helfgott, J. Hariprashad, and H. W. Murray. 1994. Role and effect of TNF-α in experimental visceral leishmaniasis. J Immunol. 153:768-772.