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Volumn 8, Issue 4, 1996, Pages 503-509

Immunity to Lyme disease: Protection, pathology and persistence

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL IMMUNITY; BORRELIA BURGDORFERI; IMMUNE RESPONSE; LYME DISEASE; PATHOLOGY; PERSISTENT INFECTION; REVIEW;

EID: 0030218954     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80038-0     Document Type: Article
Times cited : (52)

References (93)
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    • of outstanding interest. Screening of a B. burgdorferi library with infected mouse sera identified a novel protein, p21, expressed only in infected mice and not on cultured spirochetes. This provides further evidence for surface antigen modulation of B. burgdorferi during infection of the mammalian host.
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    • of special interest. A B. burgdorferi expression library was screened with serum from an infected monkey. BmpA and bmpD gene products reacted with infected monkey sera but were not expressed by cultured spirochetes, providing more evidence for antigenic modulation.
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    • of special interest. A novel gene, pG, is described which is expressed by B. burgdorferi during infection in vivo, but not found on cultured organisms. pG shows highest sequence similarity to OspF. Mice receiving immune sera raised against recombinant pG had delayed arthritis development upon infection. This is further evidence for antigenic modulation in vivo.
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    • Wallich, R.1    Brenner, C.2    Kramer, M.D.3    Simon, M.M.4
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    • Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue
    • of special interest. This study provides evidence for the expression of an OspF homologue by B. burgdorferi in infected animals but not in cultured organisms, and provides more evidence for surface antigen modulation.
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    • of special interest. Antigenic switching was directly demonstrated by fluorescent antibody staining of freshly recovered B. burgdorferi from infected mice. The infecting culture expressed only OspA whereas by 30 days post-infection spirochetes recovered from the peritoneum expressed only OspC.
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    • of special interest. B. burgdorferi was reisolated from mouse skin at the fifth zoonotic cycle and compared with the cultured parent strain. Analysis with monoclonal antibodies showed differential expression of a subset of antigens between parent and reisolate, providing more evidence for surface antigen modulation while in the mammal or tick.
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