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1
-
-
0029183795
-
Lyme disease
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of outstanding interest. An excellent on the epidemiology and clinical aspects of Lyme disease.
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Nocton JJ, Steere AC. Lyme disease. of outstanding interest Adv Int Med. 40:1995;69-117 An excellent on the epidemiology and clinical aspects of Lyme disease.
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(1995)
Adv Int Med
, vol.40
, pp. 69-117
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-
Nocton, J.J.1
Steere, A.C.2
-
2
-
-
0028057617
-
Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis
-
Nocton JJ, Dressler F, Rutledge BJ, Rys PN, Persing DH, Steere AC. Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis. N Engl J Med. 330:1994;229-234.
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N Engl J Med
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-
Nocton, J.J.1
Dressler, F.2
Rutledge, B.J.3
Rys, P.N.4
Persing, D.H.5
Steere, A.C.6
-
3
-
-
0027733804
-
Chronic Lyme borreliosis in the laboratory mouse
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Barthold SW, De Souza MS, Janotka JL, Smith AL, Persing DH. Chronic Lyme borreliosis in the laboratory mouse. Am J Pathol. 143:1993;959-971.
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Am J Pathol
, vol.143
, pp. 959-971
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Barthold, S.W.1
De Souza, M.S.2
Janotka, J.L.3
Smith, A.L.4
Persing, D.H.5
-
4
-
-
0028082025
-
Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues
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Yang L, Weis JH, Eichwald E, Kolbert CP, Persing DH, Weis JJ. Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues. Infect Immun. 62:1994;492-500.
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Infect Immun
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, pp. 492-500
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Yang, L.1
Weis, J.H.2
Eichwald, E.3
Kolbert, C.P.4
Persing, D.H.5
Weis, J.J.6
-
5
-
-
0027495494
-
Passive immunizing activity of sera from mice infected with Borrelia burgdorferi
-
Barthold SW, Bockenstedt LK. Passive immunizing activity of sera from mice infected with Borrelia burgdorferi. Infect Immun. 61:1993;4696-4702.
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(1993)
Infect Immun
, vol.61
, pp. 4696-4702
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-
Barthold, S.W.1
Bockenstedt, L.K.2
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6
-
-
0028363415
-
Protection against Borrelia burgdorferi infection in scid mice is conferred by presensitized spleen cells and partially by B but not T cells alone
-
Schaible UE, Wallich R, Kramer MD, Nerz G, Stehle T, Museteanu C, Simon MM. Protection against Borrelia burgdorferi infection in scid mice is conferred by presensitized spleen cells and partially by B but not T cells alone. Int Immunol. 6:1994;671-681.
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(1994)
Int Immunol
, vol.6
, pp. 671-681
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-
Schaible, U.E.1
Wallich, R.2
Kramer, M.D.3
Nerz, G.4
Stehle, T.5
Museteanu, C.6
Simon, M.M.7
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7
-
-
0029656118
-
Evolution of the serologic response to Borrelia burgdorferi in treated patients with culture-confirmed erythema migrans
-
of outstanding interest. Serially collected sera from 46 patients infected with B. burgdorferi were assessed for IgM and IgG responses.
-
Augero-Rosenfeld ME, Nowakowski J, Bittker S, Cooper D, Nadelman RB, Wormser GP. Evolution of the serologic response to Borrelia burgdorferi in treated patients with culture-confirmed erythema migrans. of outstanding interest J Clin Microbiol. 34:1996;1-9 Serially collected sera from 46 patients infected with B. burgdorferi were assessed for IgM and IgG responses.
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(1996)
J Clin Microbiol
, vol.34
, pp. 1-9
-
-
Augero-Rosenfeld, M.E.1
Nowakowski, J.2
Bittker, S.3
Cooper, D.4
Nadelman, R.B.5
Wormser, G.P.6
-
8
-
-
0026721358
-
Selection of an escape variant of Borrelia burgdorferi by use of bactericidal monoclonal antibodies to OspB
-
Coleman JL, Rogers RC, Benach JL. Selection of an escape variant of Borrelia burgdorferi by use of bactericidal monoclonal antibodies to OspB. Infect Immun. 60:1992;3098-3104.
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Infect Immun
, vol.60
, pp. 3098-3104
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Coleman, J.L.1
Rogers, R.C.2
Benach, J.L.3
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9
-
-
0026761405
-
Antibody-resistant mutants of Borrelia burgdorferi: In vitro selection and characterization
-
Sadziene A, Rosa PA, Thompson PA, Hogan DM, Barbour AG. Antibody-resistant mutants of Borrelia burgdorferi: in vitro selection and characterization. J Exp Med. 176:1992;799-809.
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(1992)
J Exp Med
, vol.176
, pp. 799-809
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-
Sadziene, A.1
Rosa, P.A.2
Thompson, P.A.3
Hogan, D.M.4
Barbour, A.G.5
-
10
-
-
0025202254
-
Protection of mice against the Lyme disease agent by immunizing with recombinant OspA
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Fikrig E, Barthold SW, Kantor FS, Flavell RA. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science. 250:1990;553-555.
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(1990)
Science
, vol.250
, pp. 553-555
-
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Fikrig, E.1
Barthold, S.W.2
Kantor, F.S.3
Flavell, R.A.4
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11
-
-
0026764138
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Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice
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Fikrig E, Telford SR III, Barthold SW, Kantor FS, Spielman A, Flavell RA. Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proc Natl Acad Sci USA. 89:1992;5418-5421.
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(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 5418-5421
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-
Fikrig, E.1
Telford S.R. III2
Barthold, S.W.3
Kantor, F.S.4
Spielman, A.5
Flavell, R.A.6
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12
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-
0001983997
-
Lyme borreliosis in the laboratory mouse
-
Barthold SW. Lyme borreliosis in the laboratory mouse. J Spirochetal Tick-borne Dis. 3:1996;22-44.
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(1996)
J Spirochetal Tick-borne Dis
, vol.3
, pp. 22-44
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-
Barthold, S.W.1
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13
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0028903299
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The Lyme disease vaccine candidate outer surface protein A (OspA) in a formulation compatible with human use protects mice against natural tick transmission of B. burgdorferi
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Golde WT, Burkot TR, Piesman J, Dolan MC, Capiau C, Hauser P, Dequesne G, Lobet Y. The Lyme disease vaccine candidate outer surface protein A (OspA) in a formulation compatible with human use protects mice against natural tick transmission of B. burgdorferi. Vaccine. 13:1995;435-441.
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(1995)
Vaccine
, vol.13
, pp. 435-441
-
-
Golde, W.T.1
Burkot, T.R.2
Piesman, J.3
Dolan, M.C.4
Capiau, C.5
Hauser, P.6
Dequesne, G.7
Lobet, Y.8
-
14
-
-
0029053627
-
Abilities of OspA proteins from different seroprotective groups of Borrelia burgdorferi to protect hamsters from infection
-
of outstanding interest. Recombinant OspA protein was produced from B. burgdorferi sensu stricto, and from the related B. burgdorferi sensu lato strains (B. afzelli and B. garinii). OspA induced protective immunity was not found to extend to isolates from heterologous species.
-
Lovrich SD, Callister SM, DuChateau BK, Lim LCL, Winfrey J, Day SP, Schell RF. Abilities of OspA proteins from different seroprotective groups of Borrelia burgdorferi to protect hamsters from infection. of outstanding interest Infect Immun. 63:1995;2113-2119 Recombinant OspA protein was produced from B. burgdorferi sensu stricto, and from the related B. burgdorferi sensu lato strains (B. afzelli and B. garinii). OspA induced protective immunity was not found to extend to isolates from heterologous species.
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(1995)
Infect Immun
, vol.63
, pp. 2113-2119
-
-
Lovrich, S.D.1
Callister, S.M.2
DuChateau, B.K.3
Lim, L.C.L.4
Winfrey, J.5
Day, S.P.6
Schell, R.F.7
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15
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0028904558
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Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis
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Dunne M, Al-Ramadi BK, Barthold SW, Flavell RA, Fiknig E. Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis. Infect Immun. 63:1995;1611-1614.
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(1995)
Infect Immun
, vol.63
, pp. 1611-1614
-
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Dunne, M.1
Al-Ramadi, B.K.2
Barthold, S.W.3
Flavell, R.A.4
Fiknig, E.5
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16
-
-
0027254484
-
Protective immunity elicited by recombinant Bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: A candidate Lyme disease vaccine
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Stover CK, Bansal GP, Hanson MS, Burlein JE, Palaszynski SR, Young JF, Koenig S, Young DB, Sadziene A, Barbour AG. Protective immunity elicited by recombinant Bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: a candidate Lyme disease vaccine. J Exp Med. 178:1993;197-209.
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(1993)
J Exp Med
, vol.178
, pp. 197-209
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Stover, C.K.1
Bansal, G.P.2
Hanson, M.S.3
Burlein, J.E.4
Palaszynski, S.R.5
Young, J.F.6
Koenig, S.7
Young, D.B.8
Sadziene, A.9
Barbour, A.G.10
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17
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0025949089
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Recombinant outer surface protein A from Borrelia burgdorferi induces antibodies protective against spirochetal infection in mice
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Simon MM, Schaible UU, Kramer MD, Eckerskom C, Museteanu C, Muller-Hermelink HK, Wallich R. Recombinant outer surface protein A from Borrelia burgdorferi induces antibodies protective against spirochetal infection in mice. J Infect Dis. 164:1991;123-132.
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(1991)
J Infect Dis
, vol.164
, pp. 123-132
-
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Simon, M.M.1
Schaible, U.U.2
Kramer, M.D.3
Eckerskom, C.4
Museteanu, C.5
Muller-Hermelink, H.K.6
Wallich, R.7
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18
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0028787662
-
Safety and immunogenicity of an outer surface protein A vaccine in subjects with previous Lyme disease
-
of special interest. This study demonstrates the safety of the OspA vaccine, even in individuals previously exposed to B. burgdorferi.
-
Schoen RT, Meurice F, Brunet CM, Cretella S, Krause DS, Craft JE, Fikrig E. Safety and immunogenicity of an outer surface protein A vaccine in subjects with previous Lyme disease. of special interest J Infect Dis. 172:1995;1324-1329 This study demonstrates the safety of the OspA vaccine, even in individuals previously exposed to B. burgdorferi.
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(1995)
J Infect Dis
, vol.172
, pp. 1324-1329
-
-
Schoen, R.T.1
Meurice, F.2
Brunet, C.M.3
Cretella, S.4
Krause, D.S.5
Craft, J.E.6
Fikrig, E.7
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19
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0028236921
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Safety and immunogenicity of a recombinant outer surface protein A Lyme vaccine
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Keller D, Koster FT, Marks DH, Hosbach P, Erdile LF, Mays JP. Safety and immunogenicity of a recombinant outer surface protein A Lyme vaccine. JAMA. 271:1994;1764-1768.
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(1994)
JAMA
, vol.271
, pp. 1764-1768
-
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Keller, D.1
Koster, F.T.2
Marks, D.H.3
Hosbach, P.4
Erdile, L.F.5
Mays, J.P.6
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20
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0028966088
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Vaccination against Lyme disease caused by diverse Borrelia burgdorferi
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Fikrig E, Telford SR III, Wallich R, Chen M, Lobet Y, Matuschka FR, Kimsley RB, Kantor FS, Barthold SW, Spielman A, Flavell RA. Vaccination against Lyme disease caused by diverse Borrelia burgdorferi. J Exp Med. 181:1995;215-221.
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(1995)
J Exp Med
, vol.181
, pp. 215-221
-
-
Fikrig, E.1
Telford S.R. III2
Wallich, R.3
Chen, M.4
Lobet, Y.5
Matuschka, F.R.6
Kimsley, R.B.7
Kantor, F.S.8
Barthold, S.W.9
Spielman, A.10
Flavell, R.A.11
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21
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0029160257
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Incomplete protection of hamsters vaccinated with unlipidated OspA from Borrelia burgdorferi infection is associated with low levels of antibody to an epitope defined by mAb LA-2
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Johnson BJB, Sviat SL, Happ CM, Dunn JJ, Frantz JC, Mayer LW, Piesman J. Incomplete protection of hamsters vaccinated with unlipidated OspA from Borrelia burgdorferi infection is associated with low levels of antibody to an epitope defined by mAb LA-2. Vaccine. 13:1995;1086-1094.
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(1995)
Vaccine
, vol.13
, pp. 1086-1094
-
-
Johnson, B.J.B.1
Sviat, S.L.2
Happ, C.M.3
Dunn, J.J.4
Frantz, J.C.5
Mayer, L.W.6
Piesman, J.7
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22
-
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0030025949
-
Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine
-
of outstanding interest. This study shows the loss of OspA on the spirochete within the tick as it takes the blood meal. It also demonstrates that antibodies to OspA work within the vector only during a limited portion of the tick's blood meal.
-
De Silva AM, Telford SR III, Brunet LR, Barthold SW, Fikrig E. Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. of outstanding interest J Exp Med. 183:1996;271-275 This study shows the loss of OspA on the spirochete within the tick as it takes the blood meal. It also demonstrates that antibodies to OspA work within the vector only during a limited portion of the tick's blood meal.
-
(1996)
J Exp Med
, vol.183
, pp. 271-275
-
-
De Silva, A.M.1
Telford S.R. III2
Brunet, L.R.3
Barthold, S.W.4
Fikrig, E.5
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23
-
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0028331281
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Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83 kilodalton antigen
-
Probert WS, LeFebvre RB. Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83 kilodalton antigen. Infect Immun. 62:1994;1920-1926.
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(1994)
Infect Immun
, vol.62
, pp. 1920-1926
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Probert, W.S.1
LeFebvre, R.B.2
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24
-
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0028281946
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Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice
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Nguyen T-PK, Lam TT, Barthold SW, Telford SR, Flavell RA, Fikrig E. Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice. Infect Immun. 62:1994;2079-2084.
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(1994)
Infect Immun
, vol.62
, pp. 2079-2084
-
-
Nguyen T-PK1
Lam, T.T.2
Barthold, S.W.3
Telford, S.R.4
Flavell, R.A.5
Fikrig, E.6
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25
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0029036568
-
Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi
-
of outstanding interest. Mice were immunized with OspA, then challenged with cultured organisms or organisms present in skin grafted from an infected mouse. Immunized mice challenged with transplants were susceptible to infection, developing carditis and joint inflammation as well. This study shows that spirochetes alter their surface antigens while in the mouse host.
-
Barthold SW, Fikrig E, Bockenstedt LK, Persing DH. Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. of outstanding interest Infect Immun. 63:1995;2255-2261 Mice were immunized with OspA, then challenged with cultured organisms or organisms present in skin grafted from an infected mouse. Immunized mice challenged with transplants were susceptible to infection, developing carditis and joint inflammation as well. This study shows that spirochetes alter their surface antigens while in the mouse host.
-
(1995)
Infect Immun
, vol.63
, pp. 2255-2261
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Barthold, S.W.1
Fikrig, E.2
Bockenstedt, L.K.3
Persing, D.H.4
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26
-
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0027448628
-
Protective immunity is induced by a Borrelia burgdorferi mutant that lacks OspA and OspB
-
Hughes CAN, Engstrom SM, Coleman LA, Kodner CB, Johnson RC. Protective immunity is induced by a Borrelia burgdorferi mutant that lacks OspA and OspB. Infect Immun. 61:1993;5115-5122.
-
(1993)
Infect Immun
, vol.61
, pp. 5115-5122
-
-
Hughes, C.A.N.1
Engstrom, S.M.2
Coleman, L.A.3
Kodner, C.B.4
Johnson, R.C.5
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27
-
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0029898730
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A flagella-less mutant of Borrelia burgdorferi as a live attenuated vaccine in the murine model of Lyme disease
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Sadziene A, Thompson PA, Barbour AG. A flagella-less mutant of Borrelia burgdorferi as a live attenuated vaccine in the murine model of Lyme disease. J Infect Dis. 173:1996;1184-1193.
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(1996)
J Infect Dis
, vol.173
, pp. 1184-1193
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Sadziene, A.1
Thompson, P.A.2
Barbour, A.G.3
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28
-
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0028098176
-
Variability of a bacterial surface protein and disease expression in a possible mouse model of systemic Lyme borreliosis
-
Cadavid D, Thomas DD, Crawley R, Barbour AG. Variability of a bacterial surface protein and disease expression in a possible mouse model of systemic Lyme borreliosis. J Exp Med. 179:1994;631-642.
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(1994)
J Exp Med
, vol.179
, pp. 631-642
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-
Cadavid, D.1
Thomas, D.D.2
Crawley, R.3
Barbour, A.G.4
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29
-
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0027207678
-
OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection
-
Fikrig E, Barthold SW, Flavell RA. OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection. Infect Immun. 61:1993;2553-2557.
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(1993)
Infect Immun
, vol.61
, pp. 2553-2557
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Fikrig, E.1
Barthold, S.W.2
Flavell, R.A.3
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30
-
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0028926240
-
Induction of an outer surface protein on Borrelia burgdorferi during tick feeding
-
of outstanding interest. A change in surface Osp expression from OspA to OspC was observed when cultured B. burgdorferi were shifted from 25° to 37°C. In the tick, it took both a temperature shift and blood meal to alter spirochete protein expression. This study shows that B. burgdorferi alteration in Osp expression occurs within the tick vector.
-
Schwan TG, Piesman J, Golde WT, Dolan MC, Rosa PA. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. of outstanding interest Proc Natl Acad Sci USA. 92:1995;2909-2913 A change in surface Osp expression from OspA to OspC was observed when cultured B. burgdorferi were shifted from 25° to 37°C. In the tick, it took both a temperature shift and blood meal to alter spirochete protein expression. This study shows that B. burgdorferi alteration in Osp expression occurs within the tick vector.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 2909-2913
-
-
Schwan, T.G.1
Piesman, J.2
Golde, W.T.3
Dolan, M.C.4
Rosa, P.A.5
-
31
-
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0027934212
-
Quantitation of the Borrelia burgdorferi outer surface protein A in lxodes scapularis: Fluctuations during the tick life cycle, doubling times, and loss while feeding
-
Burkot TR, Piesman J, Wirtz RA. Quantitation of the Borrelia burgdorferi outer surface protein A in lxodes scapularis: fluctuations during the tick life cycle, doubling times, and loss while feeding. J Infect Dis. 170:1994;883-889.
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(1994)
J Infect Dis
, vol.170
, pp. 883-889
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Burkot, T.R.1
Piesman, J.2
Wirtz, R.A.3
-
32
-
-
0028828202
-
Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi
-
of outstanding interest. B. burgdorferi were cultured at 23° and 35°C with expression of OspE and OspF occurring only at the higher temperature. This study shows that ability of B. burgdorferi to alter its surface antigen expression depending on its environment.
-
Stevenson B, Schwan TG, Rosa PA. Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi. of outstanding interest Infect Immun. 63:1995;4535-4539 B. burgdorferi were cultured at 23° and 35°C with expression of OspE and OspF occurring only at the higher temperature. This study shows that ability of B. burgdorferi to alter its surface antigen expression depending on its environment.
-
(1995)
Infect Immun
, vol.63
, pp. 4535-4539
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-
Stevenson, B.1
Schwan, T.G.2
Rosa, P.A.3
-
33
-
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0028335843
-
A 9.0 kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: Evidence for expression only during infection
-
Champion CI, Blanco DR, Skare JT, Haake DA, Giladi M, Foley D, Miller JN, Lovett MA. A 9.0 kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: evidence for expression only during infection. Infect Immun. 62:1994;2653-2661.
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(1994)
Infect Immun
, vol.62
, pp. 2653-2661
-
-
Champion, C.I.1
Blanco, D.R.2
Skare, J.T.3
Haake, D.A.4
Giladi, M.5
Foley, D.6
Miller, J.N.7
Lovett, M.A.8
-
34
-
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0029050627
-
Borrelia burgdorferi genes selectively expressed in the infected host
-
of outstanding interest. Screening of a B. burgdorferi library with infected mouse sera identified a novel protein, p21, expressed only in infected mice and not on cultured spirochetes. This provides further evidence for surface antigen modulation of B. burgdorferi during infection of the mammalian host.
-
Suk K, Das S, Sun W, Jwang B, Barthold SW, Flavell RA, Fikrig E. Borrelia burgdorferi genes selectively expressed in the infected host. of outstanding interest Proc Natl Acad Sci USA. 92:1995;4269-4273 Screening of a B. burgdorferi library with infected mouse sera identified a novel protein, p21, expressed only in infected mice and not on cultured spirochetes. This provides further evidence for surface antigen modulation of B. burgdorferi during infection of the mammalian host.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 4269-4273
-
-
Suk, K.1
Das, S.2
Sun, W.3
Jwang, B.4
Barthold, S.W.5
Flavell, R.A.6
Fikrig, E.7
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35
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0030002056
-
Molecular characterization, genomic arrangement, and expression of bmpD, a new member of the bmp class of genes encoding membrane proteins of Borrelia burgdorferi
-
of special interest. A B. burgdorferi expression library was screened with serum from an infected monkey. BmpA and bmpD gene products reacted with infected monkey sera but were not expressed by cultured spirochetes, providing more evidence for antigenic modulation.
-
Ramamoorthy R, Povinelli L, Philipp MT. Molecular characterization, genomic arrangement, and expression of bmpD, a new member of the bmp class of genes encoding membrane proteins of Borrelia burgdorferi. of special interest Infect Immun. 64:1996;1259-1264 A B. burgdorferi expression library was screened with serum from an infected monkey. BmpA and bmpD gene products reacted with infected monkey sera but were not expressed by cultured spirochetes, providing more evidence for antigenic modulation.
-
(1996)
Infect Immun
, vol.64
, pp. 1259-1264
-
-
Ramamoorthy, R.1
Povinelli, L.2
Philipp, M.T.3
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36
-
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0029122852
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Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo
-
of special interest. A novel gene, pG, is described which is expressed by B. burgdorferi during infection in vivo, but not found on cultured organisms. pG shows highest sequence similarity to OspF. Mice receiving immune sera raised against recombinant pG had delayed arthritis development upon infection. This is further evidence for antigenic modulation in vivo.
-
Wallich R, Brenner C, Kramer MD, Simon MM. Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo. of special interest Infect Immun. 63:1995;3327-3335 A novel gene, pG, is described which is expressed by B. burgdorferi during infection in vivo, but not found on cultured organisms. pG shows highest sequence similarity to OspF. Mice receiving immune sera raised against recombinant pG had delayed arthritis development upon infection. This is further evidence for antigenic modulation in vivo.
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Infect Immun
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Wallich, R.1
Brenner, C.2
Kramer, M.D.3
Simon, M.M.4
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37
-
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0029597816
-
Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue
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of special interest. This study provides evidence for the expression of an OspF homologue by B. burgdorferi in infected animals but not in cultured organisms, and provides more evidence for surface antigen modulation.
-
Akins DR, Porcella SF, Popova TG, Shevchenko D, Baker SI, Li M, Norgard MV, Radolf JD. Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue. of special interest Mol Microbiol. 18:1995;507-520 This study provides evidence for the expression of an OspF homologue by B. burgdorferi in infected animals but not in cultured organisms, and provides more evidence for surface antigen modulation.
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Mol Microbiol
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Akins, D.R.1
Porcella, S.F.2
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Baker, S.I.5
Li, M.6
Norgard, M.V.7
Radolf, J.D.8
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38
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0030048119
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Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: Exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease
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of special interest. Antigenic switching was directly demonstrated by fluorescent antibody staining of freshly recovered B. burgdorferi from infected mice. The infecting culture expressed only OspA whereas by 30 days post-infection spirochetes recovered from the peritoneum expressed only OspC.
-
Montgomery RM, Malawista SE, Feen KJM, Bockenstedt LK. Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. of special interest J Exp Med. 183:1996;261-269 Antigenic switching was directly demonstrated by fluorescent antibody staining of freshly recovered B. burgdorferi from infected mice. The infecting culture expressed only OspA whereas by 30 days post-infection spirochetes recovered from the peritoneum expressed only OspC.
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Montgomery, R.M.1
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Feen, K.J.M.3
Bockenstedt, L.K.4
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39
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0028845228
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Variation in antigenicity and infectivity of derivatives of Borrelia burgdorferi, strain B31, maintained in the natural zoonotic cycle compared with maintenance in culture
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of special interest. B. burgdorferi was reisolated from mouse skin at the fifth zoonotic cycle and compared with the cultured parent strain. Analysis with monoclonal antibodies showed differential expression of a subset of antigens between parent and reisolate, providing more evidence for surface antigen modulation while in the mammal or tick.
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Golde WT, Dolan MC. Variation in antigenicity and infectivity of derivatives of Borrelia burgdorferi, strain B31, maintained in the natural zoonotic cycle compared with maintenance in culture. of special interest Infect Immun. 63:1995;4795-4801 B. burgdorferi was reisolated from mouse skin at the fifth zoonotic cycle and compared with the cultured parent strain. Analysis with monoclonal antibodies showed differential expression of a subset of antigens between parent and reisolate, providing more evidence for surface antigen modulation while in the mammal or tick.
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Golde, W.T.1
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40
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Stevenson B, Bockenstedt LK, Barthold SW. Expression and gene sequence of outer surface protein C of Borrelia burgdorferi reisolated from chronically infected mice. Infect Immun. 62:1994;3568-3571.
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Stevenson, B.1
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41
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Persing DH, Mathiesen D, Podzorski D, Barthold SW. Genetic stability of Borrelia burgdorferi recovered from chronically infected immunocompetent mice. Infect Immun. 62:1994;3521-3527.
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Persing, D.H.1
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43
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Margolis, N.1
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Weiss, J.J.1
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Radolf, J.D.1
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46
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Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide by the cytokine-inducible pathway
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Ma Y, Seiler KP, Tai KF, Yang L, Woods M, Weiss JJ. Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide by the cytokine-inducible pathway. Infect Immun. 62:1994;3663-3671.
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Ma, Y.1
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47
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Ma Y, Weiss JJ. Borrelia burgdorferi outer surface lipoproteins OspA and OspB possess B-cell mitogenic and cytokine-stimulatory properties. Infect Immun. 61:1993;3843-3853.
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Ma, Y.1
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48
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0025943274
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Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis
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Radolf, J.D.1
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49
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Honarvar N, Schaible UE, Galanos C, Wallich R, Simon MM. A 14 000 MW lipoprotein and a glycolipid-like structure of Borrelia burgdorferi induce proliferation and immunoglobulin production in mouse B cells at high frequencies. Immunology. 82:1994;389-396.
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Honarvar, N.1
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Whitmire, W.M.1
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51
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of special interest. Injection of synthetic lipopeptides based on the structure of OspA and OspB induced inflammatory infiltration into dermal tissue characteristic of the skin lesions of Lyme disease and syphilis.
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Norgard MV, Riley BS, Richardson JA, Radolf JD. Dermal inflammation elicited by synthetic analogs of Treponema pallidum and Borrelia burgdorferi lipoproteins. of special interest Infect Immun. 63:1995;1507-1515 Injection of synthetic lipopeptides based on the structure of OspA and OspB induced inflammatory infiltration into dermal tissue characteristic of the skin lesions of Lyme disease and syphilis.
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Norgard, M.V.1
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52
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53
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Tatro, J.B.1
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56
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Kenefick KB, Lim LCL, Alder JD, Schmitz FL, Czurprynski CJ, Schell RF. Induction of interleukin-1 release by high and low passage isolates of Borrelia burgdorferi. J Infect Dis. 167:1993;1086-1092.
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Kenefick, K.B.1
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Schell, R.F.6
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58
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0026713722
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Live Borrelia burgdorferi preferentially activate interleukin-1β gene expression and protein synthesis over the interleukin-1 receptor antagonist
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59
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Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver
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Schaible UE, Gay S, Museteanu C, Kramer MD, Zimmer G, Eichmann K, Museteanu U, Simon MM. Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver. Am J Pathol. 137:1990;811-820.
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Barthold, S.W.1
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61
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of special interest. This study shows that mice with the beige mutation develop Lyme arthritis when infected with B. burgdorferi, whereas the congenic C57/BL6 parent strain does not. This study demonstrates that the granule defect in neutrophils in the beige mice is primarily involved in the development of the pathology, presumably by allowing expansion of spirochetes in vivo.
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Barthold, S.W.1
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of special interest. The prevalence of T-cell lines directed to OspA from patients with treatment-resistant Lyme arthritis was further characterized by peptide mapping. Dominant epitopes of OspA were recognized by patients' T cells, suggesting the existence of an arthritogenic epitope.
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of outstanding interest. This study shows that although infection with B. burgdorferi induces nitric oxide production in the mouse, nitric oxide is not involved in host resistance or in arthritis development. This study supports the idea that B. burgdorferi is not intracellular during an essential part of its life within the mammal.
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