-
1
-
-
0028970060
-
Interleukin-12: A pro-inflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptative immunity
-
Trinchieri, G. (1995) Interleukin-12: a pro-inflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptative immunity, Ann. Rev. Immunol. 13, 252-276
-
(1995)
Ann. Rev. Immunol.
, vol.13
, pp. 252-276
-
-
Trinchieri, G.1
-
2
-
-
0009595788
-
62nd Forum in Immunology: Immunoregulation by interleukin-12
-
Trinchieri, G. and Scott, P. (1995) 62nd Forum in Immunology: immunoregulation by interleukin-12, Res. Immunol. 146, 419-656
-
(1995)
Res. Immunol.
, vol.146
, pp. 419-656
-
-
Trinchieri, G.1
Scott, P.2
-
3
-
-
0029099391
-
Effects of IL-12 on immune responses to microbial infections: A key mediator in regulating disease outcome
-
Biron, C.A. and Gazzinelli, R.T. (1995) Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr. Opin. Immunol. 7, 485-496
-
(1995)
Curr. Opin. Immunol.
, vol.7
, pp. 485-496
-
-
Biron, C.A.1
Gazzinelli, R.T.2
-
4
-
-
0024467154
-
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
-
Kobayashi, M. et al. (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes, J. Exp. Med. 170, 827-846
-
(1989)
J. Exp. Med.
, vol.170
, pp. 827-846
-
-
Kobayashi, M.1
-
5
-
-
0025875022
-
Cloning of cDNA for natural killer stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
-
Wolf, S. et al. (1991) Cloning of cDNA for natural killer stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146, 3074-3081
-
(1991)
J. Immunol.
, vol.146
, pp. 3074-3081
-
-
Wolf, S.1
-
6
-
-
0026701132
-
Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells
-
D'Andrea, A. et al. (1992) Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J. Exp. Med., 176, 1387-1398
-
(1992)
J. Exp. Med.
, vol.176
, pp. 1387-1398
-
-
D'Andrea, A.1
-
7
-
-
0027264849
-
Interleukin 12 is required for the T-lymphocyte independent induction of interferon-γ by an intracellular parasite and induces resistance in T-cell-deficient hosts
-
Gazzinelli, R.T. et al. (1993) Interleukin 12 is required for the T-lymphocyte independent induction of interferon-γ by an intracellular parasite and induces resistance in T-cell-deficient hosts, Proc. Natl Acad. Sci. USA 90, 6115-6119
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 6115-6119
-
-
Gazzinelli, R.T.1
-
8
-
-
0028262475
-
Impaired interleukin 12 production in human immuno-deficiency virus-infected patients
-
Chehimi, J. et al. (1994) Impaired interleukin 12 production in human immuno-deficiency virus-infected patients, J. Exp. Med. 179, 1361-1366
-
(1994)
J. Exp. Med.
, vol.179
, pp. 1361-1366
-
-
Chehimi, J.1
-
9
-
-
0028158318
-
+ T cells during initiation of infection
-
+ T cells during initiation of infection, J. Exp. Med. 179, 447-456
-
(1994)
J. Exp. Med.
, vol.179
, pp. 447-456
-
-
Reiner, S.L.1
-
10
-
-
0030021084
-
Leishmania promastigotes selectively inhibit IL-12 induction in bone-marrow derived macrophages from susceptible and resistant mice
-
Carrera, L. et al. (1996) Leishmania promastigotes selectively inhibit IL-12 induction in bone-marrow derived macrophages from susceptible and resistant mice, J. Exp. Med. 183, 515-526
-
(1996)
J. Exp. Med.
, vol.183
, pp. 515-526
-
-
Carrera, L.1
-
11
-
-
0029946887
-
Biochemical characterization and protein kinase C dependency of monokine inducing activities in Toxoplasma gondii
-
in press
-
Grunvald, E. et al. Biochemical characterization and protein kinase C dependency of monokine inducing activities in Toxoplasma gondii. Infect. Immun. (in press)
-
Infect. Immun.
-
-
Grunvald, E.1
-
12
-
-
0028176574
-
IFN-γ induces IL-12 mRNA expression by a murine macrophage cell line, J774
-
Yoshida, A., Koide, Y., Uchijima, M. and Yoshida, T.O. (1994) IFN-γ induces IL-12 mRNA expression by a murine macrophage cell line, J774, Biochem. Biophys. Res. Commun. 198, 857-861
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.198
, pp. 857-861
-
-
Yoshida, A.1
Koide, Y.2
Uchijima, M.3
Yoshida, T.O.4
-
13
-
-
0030064148
-
The interleukin 12 p40 gene promoter is primed by IFN-γ in monocytic cells
-
Ma, X. et al. (1996) The interleukin 12 p40 gene promoter is primed by IFN-γ in monocytic cells, J. Exp. Med. 183, 147-157
-
(1996)
J. Exp. Med.
, vol.183
, pp. 147-157
-
-
Ma, X.1
-
14
-
-
0028209541
-
Neutralization of IL-12 decreases resistance to Listeria in SCID and CB-17 mice, reversal by IFN-γ
-
Tripp, C.S. et al. (1994) Neutralization of IL-12 decreases resistance to Listeria in SCID and CB-17 mice, reversal by IFN-γ. J. Immunol. 152, 1883-1887
-
(1994)
J. Immunol.
, vol.152
, pp. 1883-1887
-
-
Tripp, C.S.1
-
15
-
-
0027939611
-
Parasite induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii
-
Gazzinelli, R.T. et al. (1994) Parasite induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii, J. Immunol. 153, 2533-2543
-
(1994)
J. Immunol.
, vol.153
, pp. 2533-2543
-
-
Gazzinelli, R.T.1
-
16
-
-
0027491655
-
+ T cells to enhance priming for IFN-γ and diminishes IL-4 inhibition of such priming
-
+ T cells to enhance priming for IFN-γ and diminishes IL-4 inhibition of such priming, Proc. Natl Acad. Sci. USA 90, 10188-10192
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 10188-10192
-
-
Seder, R.A.1
Gazzinelli, A.2
Paul, W.E.3
-
17
-
-
0029156730
-
Secondary response to Listeria infection requires IFN-γ but is partially independent of IL-12
-
Tripp, C.S., Kanagawa, O. and Unanue, E.R. (1995) Secondary response to Listeria infection requires IFN-γ but is partially independent of IL-12, J. Immunol. 155, 3427-3432
-
(1995)
J. Immunol.
, vol.155
, pp. 3427-3432
-
-
Tripp, C.S.1
Kanagawa, O.2
Unanue, E.R.3
-
18
-
-
0027743305
-
Restoration of HIV-specific cell-mediated immune responses by interleukin 12 in vitro
-
Clerici, M. et al. (1993) Restoration of HIV-specific cell-mediated immune responses by interleukin 12 in vitro, Science 262, 1721-1724
-
(1993)
Science
, vol.262
, pp. 1721-1724
-
-
Clerici, M.1
-
19
-
-
0028071922
-
In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS)
-
Gazzinelli, R.T., Giese, N.A. and Morse, H.C., III (1994) In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS), J. Exp. Med. 180, 2199-2208
-
(1994)
J. Exp. Med.
, vol.180
, pp. 2199-2208
-
-
Gazzinelli, R.T.1
Giese, N.A.2
Morse III, H.C.3
-
20
-
-
0028266819
-
Effects of IL-12 on the response and susceptibility to experimental viral infections
-
Orange, CA, Wolf, S.F. and Biron, C.A. (1994) Effects of IL-12 on the response and susceptibility to experimental viral infections. J. Immunol. 152, 1253-1264
-
(1994)
J. Immunol.
, vol.152
, pp. 1253-1264
-
-
Orange, C.A.1
Wolf, S.F.2
Biron, C.A.3
-
21
-
-
0029021419
-
IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-γ-receptor deficient mice
-
Virgil, E., Schijns, C.J., Haagmans, B.L. and Horzinek, M.C. (1995) IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-γ-receptor deficient mice. J. Immunol. 155, 2525-2532
-
(1995)
J. Immunol.
, vol.155
, pp. 2525-2532
-
-
Virgil, E.1
Schijns, C.J.2
Haagmans, B.L.3
Horzinek, M.C.4
-
22
-
-
0028863450
-
IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system
-
Bi. Z. et al. (1995) IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system. J. Immunol. 155, 5684-5689
-
(1995)
J. Immunol.
, vol.155
, pp. 5684-5689
-
-
Bi, Z.1
-
24
-
-
0029078676
-
IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection
-
Flynn, J.L. et al. (1995) IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J. Immunol. 155, 2515-2524
-
(1995)
J. Immunol.
, vol.155
, pp. 2515-2524
-
-
Flynn, J.L.1
-
25
-
-
0028077508
-
IL-12 regulates T helper 1 cytokine responses in human infectious disease
-
Sieling, P.A. et al. (1994) IL-12 regulates T helper 1 cytokine responses in human infectious disease. J. Immunol. 153, 3639-3647
-
(1994)
J. Immunol.
, vol.153
, pp. 3639-3647
-
-
Sieling, P.A.1
-
26
-
-
0028987562
-
Interleukin 12 is required for IFN-γ production and lethality in lipopolysaccharide-induced shock in mice
-
Wyzocka, M. et al. (1995) Interleukin 12 is required for IFN-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25, 672-676
-
(1995)
Eur. J. Immunol.
, vol.25
, pp. 672-676
-
-
Wyzocka, M.1
-
27
-
-
0028062795
-
IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis
-
Romani, L. et al. (1994) IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis. J. Immunol. 153, 5167-5175
-
(1994)
J. Immunol.
, vol.153
, pp. 5167-5175
-
-
Romani, L.1
-
28
-
-
0029079391
-
IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ
-
Zhou, P. et al. (1995) IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ, J. Immunol. 155, 785-795
-
(1995)
J. Immunol.
, vol.155
, pp. 785-795
-
-
Zhou, P.1
-
29
-
-
0028208833
-
Cytokine treatment of central nervous system infection: Efficacy of IL-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis
-
Clemons, K.V., Brummer, E. and Stevens, D.A. (1994) Cytokine treatment of central nervous system infection: efficacy of IL-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis, Antimicrob. Agents Chemother, 38, 460-464
-
(1994)
Antimicrob. Agents Chemother
, vol.38
, pp. 460-464
-
-
Clemons, K.V.1
Brummer, E.2
Stevens, D.A.3
-
30
-
-
0027309318
-
Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective type 1 immune response
-
Sypeck, T. et al. (1993) Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective type 1 immune response. J. Exp. Med. 177, 1797-1802
-
(1993)
J. Exp. Med.
, vol.177
, pp. 1797-1802
-
-
Sypeck, T.1
-
31
-
-
0027528795
-
Recombinant interleukin 12 cures mice infected with Leishmania major
-
Heinzel, F. et al. (1993) Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med., 177, 1505-1509
-
(1993)
J. Exp. Med.
, vol.177
, pp. 1505-1509
-
-
Heinzel, F.1
-
32
-
-
0028049247
-
The adjuvant effect of interleukin 12 in a vaccine against Leishmania major
-
Afonso, L.C. et al. (1994) The adjuvant effect of interleukin 12 in a vaccine against Leishmania major. Science 263, 235-237
-
(1994)
Science
, vol.263
, pp. 235-237
-
-
Afonso, L.C.1
-
33
-
-
0028934155
-
A switch from a Th2 to Th1 type response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and pentostam
-
Nabora, G.S., Afonso, L.C.C., Farrell, J.P. and Scott, P. (1995) A switch from a Th2 to Th1 type response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and pentostam. Proc. Natl Acad. Sci. USA 92, 3142-3146
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 3142-3146
-
-
Nabora, G.S.1
Afonso, L.C.C.2
Farrell, J.P.3
Scott, P.4
-
34
-
-
0028950126
-
Interleukin 12 is effective treatment for an established systemic intracellular infection: Experimental visceral leishmaniasis
-
Murray, H.W. and Hariprashad, J. (1995) Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis, J. Exp. Med. 181, 387-391
-
(1995)
J. Exp. Med.
, vol.181
, pp. 387-391
-
-
Murray, H.W.1
Hariprashad, J.2
-
35
-
-
0029045806
-
IL-12-induced protection against blood-stage Plasmodium chaubaudi requires IFN-γ and TNF-α and occurs via nitric oxide-dependent mechanism
-
Stevenson, M.M., Tam, M.F., Wolf, S.F. and Sher, A. (1995) IL-12-induced protection against blood-stage Plasmodium chaubaudi requires IFN-γ and TNF-α and occurs via nitric oxide-dependent mechanism. J. Immunol. 155, 2545-2556
-
(1995)
J. Immunol.
, vol.155
, pp. 2545-2556
-
-
Stevenson, M.M.1
Tam, M.F.2
Wolf, S.F.3
Sher, A.4
-
36
-
-
0028037226
-
Interleukin 12: Induction of IFN-γ dependent protection against malaria
-
Sedegah, M. Finkelman, F. and Hoffman, S.L. (1994) Interleukin 12: induction of IFN-γ dependent protection against malaria. Proc. Natl Acad. Sci. USA 91, 10700-10702
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 10700-10702
-
-
Sedegah, M.1
Finkelman, F.2
Hoffman, S.L.3
-
37
-
-
0030063209
-
IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum
-
Urban, J.F et al. (1996) IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum, J. Immunol. 156, 263-268
-
(1996)
J. Immunol.
, vol.156
, pp. 263-268
-
-
Urban, J.F.1
-
38
-
-
33749410394
-
IL-12 mediates resistance to Trypanosoma cruzi infection in susceptible mice and is produced by normal murine macrophages cultured with live trypomastigotes
-
Aliberti, J.C.S. et al. (1995) IL-12 mediates resistance to Trypanosoma cruzi infection in susceptible mice and is produced by normal murine macrophages cultured with live trypomastigotes, Mem. Inst. Oswaldo Cruz 90 (Suppl. I), 172
-
(1995)
Mem. Inst. Oswaldo Cruz
, vol.90
, Issue.1 SUPPL.
, pp. 172
-
-
Aliberti, J.C.S.1
-
39
-
-
0029142790
-
An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection
-
Wynn, T.A. et al. (1995) An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature 376, 594-596
-
(1995)
Nature
, vol.376
, pp. 594-596
-
-
Wynn, T.A.1
-
40
-
-
0028096083
-
Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo
-
Gately, M.K. et al. (1994) Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo. Int. Immunol. 6, 157-167
-
(1994)
Int. Immunol.
, vol.6
, pp. 157-167
-
-
Gately, M.K.1
-
41
-
-
0027692154
-
Multifactorial nature of human immunodeficiency virus disease: Implications for therapy
-
Fauci, A.S. (1993) Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science 262, 1011-1018
-
(1993)
Science
, vol.262
, pp. 1011-1018
-
-
Fauci, A.S.1
|