Biological role of th cell subsets in candidiasis

Chemical Immunology

Volumn 63, Issue , 1996, Pages 115-137

  Romani, Luigina ^a   Puccetti, Paolo ^b   Bistoni, Francesco ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CANDIDA; CANDIDIASIS; EXPERIMENTAL ANIMAL; EXPERIMENTAL HOST; HELPER CELL; IMMUNE RESPONSE; PRIORITY JOURNAL; REVIEW; SCHISTOSOMA MANSONI;

ANIMALS; CANDIDIASIS; HUMANS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0029879015     PISSN: 10150145     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (124)

1. Ashman RB, Papadimitriou JM: What's new in the mechanisms of host resistance to Candida albicans infection? Pathol Res Pract 1990;186:527-534.
2. Calderone R, Sturtevant J: Macrophage interactions with Candida. Immunol Ser 1994;60:505-515.
3. Brummer E, Morrison GJ, Stevens DA: Recombinant and natural gamma-interferon activation of macrophages in vitro: Different dose requirements for induction of killing activity against phagocytizable and nonphagocytizable fungi. Infect Immun 1985;49:724-730.
4. Djeu JY: Cytokines and anti-fungal immunity. Adv Exp Med Biol 1992;319:217-223.
5. Cutler JE: Putative virulence factors of Candida albicans. Annu Rev Microbiol 1991;45:187-218.
6. Ghannoum MA, Abu-Elteen KH: Pathogenicity determinants of Candida Mycoses 1990;33:265-282.
7. Francis P, Walsh TJ: Current approaches to the management of fungal infections in cancer patients. Part 1. Oncology 1992;6:81-92.
8. Odds FC: Candida and candidosis, ed 2. London, Baillière-Tindall, 1988, pp 124-152.
9. Klein RS, Harris CA, Small CB, Moll B, Lesser M, Friedland GH: Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. N Engl J Med 1984;311:354-358.
10. Nelson RD, Shibata N, Podzorski RP, Herron MJ: Candida mannan: Chemistry, suppression of cell-mediated immunity, and possible mechanisms of action Clin Microbiol Rev 1991;4:1-19.
11. Garner RE, Childress Am, Human LG, Domer JE: Characterization of Candida albicans mannan-induced, mannan-specific delayed hypersensitivity suppressor cells. Infect Immun 1990;58:2613-2620.
12. Savolainen J, Koivikko A, Kalimo K, Nieminen E, Viander M: IgE, IgA and IgG antibodies and delayed skin responses towards Candida albicans antigens in atopics with and without saprophytic growth. Clin Exp Allergy 1990;20:549-554.
13. Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F: An increased level of specific IgG4 antibodies against Candida albicans in patients with bronchial asthma. J Asthma 1992;29:343-348
14. Witkin SS, Jeremias J, Ledger WJ: Vaginal eosinophils and IgE antibodies to Candida albicans in women with recurrent vaginitis. J Med Vet Mycol 1989;27:57-58.
15. Ishiguro A, Homma M, Toni S, Tanaka K: Identification of Candida albicans antigens reactive with immunoglobulin E antibody of human sera. Infect Immun 1992;60:1550-1557.
16. Regulez P, Garcia Fernandez JF, Moragues MD, Schneider J, Quindos G, Ponton J: Detection of anti-Candida albicans IgE antibodies in vaginal washes from patients with acute vulvovaginal candidiasis. Gynecol Obstet Invest 1994;37:110-114.
17. Mathews RC: Candida albicans HSP 90: Link between protective and autoimmunity. J Med Microbiol 1992;36:367-370.
18. Romagnani S: Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994;12:227-257.
19. Ashman RB. Murine candidiasis: Cell-mediated immune responses correlate directly with susceptibility and resistance to infection. Immunol Cell Biol 1990;60:15-20.
20. Cantorna MT, Balish E: Mucosal and systemic candidiasis in congenitally immunodeficient mice. Infect Immun 1990;58:1093-1100.
21. Coker LA, Mercadal CM, Rouse BT, Moore RN: Differential effects of CD4+ and CD8+ cells in acute, systemic murine candidosis. J Leukoc Biol 1992;51:305-306
22. Sieck TG, Moors MA, Buckley HR, Blank KJ: Protection against murine disseminated candidiasis mediated by a Candida albicans-specific T-cell line. Infect Immun 1993;61:3540-3543.
23. Bistom F, Vecchiarelli A, Cenci E, Puccetti P, Marconi P, Cassone A: Evidence for macrophage-mediated protection against lethal Candida albicans infection. Infect Immun 1986;51.668-674.
24. Bistoni F, Verducci G, Perito S, Vecchiarelli A, Puccetti P, Marconi P, Cassone A: Immunomodulation by a low-virulence, agerminative variant of Candida albicans: Further evidence for macrophage activation as one of the effector mechanisms of nonspecific anti-infectious protection. J Med Vet Mycol 1988;26:285-299.
25. Vecchiarelli A, Cenci E, Puliti M, Blasi E, Puccetti P, Cassone A, Bistoni F: Protective immunity induced by low-virulence Candida albicans: Cytokine production in the development of the anti-infectious state. Cell Immunol 1989.124:334-344.
26. Cenci E, Bartocci A, Puccetti P, Mocci S, Stanley ER, Bistoni F: Macrophage colony-stimulating factor in murine candidiasis: Serum and tissue levels during infection and protective effect of exogenous administration. Infect Immun 1991;59:868-872.
27. Mosmann TR, Coffman RL: Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol 1989;46.111-147.
28. Romani L, Cenci E, Mencacci E, Spaccapelo R, Grohmann U, Puccetti P, Bistoni F: Gamma Interferon modifies CD4+ subset expression in murine candidiasis. Infect Immun 1992;60:4950-4952.
29. Romani L, Mencacci A, Cenci E, Mosci P, Vitellozzi G, Grohmann U, Puccetti P, Bistoni F: Course of primary candidiasis in T-cell depleted mice infected with attenuated variant cells. J Infect Dis 1992;166:1384-1392.
30. Cenci E, Romani L, Vecchiarelli A, Puccetti P, Bistoni F: Role of L3T4+ lymphocytes in protective immunity to systemic Candida albicans infection in mice. Infect Immun 1989;57:3581-3587.
31. Cenci E, Romani L, Vecchiarelli A, Puccetti P, Bistoni F: T cell subsets and IFN-γ production in resistance to systemic candidosis in immunized mice J Immunol 1990;144:4333-4339.
32. Romani L, Mocci S, Cenci E, Rossi R, Puccetti P, Bistoni F: Candida albicans-specific Lyt-2+ lymphocytes with cytolytic activity. Eur J Immunol 1991;21:1567-1570.
33. Romani L, Mocci S, Bietta C, Lanfaloni L, Puccetti P, Bistoni F: Th1 and Th2 cytokine secretion patterns in murine candidiasis: Association of Th1 responses with acquired resistance. Infect Immun 1991;59:4647-4654.
34. Cantorna MT, Balish E: Role of CD4+ lymphocytes in resistance to mucosal candidiasis. Infect Immun 1991,59:2447-2455.
35. Bistoni F, Cenci E, Mencacci A, Schiaffella E, Mosci P, Puccetti P, Romani L Mucosal and systemic T helper cell function after intragastric colonization of adult mice with Candida albicans J Infect Dis 1993;168:1449-1457.
36. Fidel PL Jr, Lynch ME, Sobel JD. Candida-specific cell-mediated immunity is demonstrable in mice with experimental vaginal candidiasis. Infect Immun 1993,61:1990-1995.
37. Fidel PL Jr, Lynch ME, Sobel JD: Candida-specific Th1-type responsiveness in mice with experimental vaginal candidiasis Infect Immun 1993;61:4202-4207.
38. Ausiello CM, Urbani F, Gessani S, Spagnoli GC, Gomez M, Cassone A: Cytokine gene expression in human peripheral blood mononuclear cells stimulated by mannoprotein constituents from Candida albicans. Infect Immun 1993.61:4105-4111.
39. Domer JE: Intragastric colonization of infant mice with Candida albicans induces systemic immunity demonstrable upon challenge as adults. J Infect Dis 1988.157:950-958.
40. Marodi L, Schreiber S, Anderson DC, MacDermott RP, Korchak HM, Johnston RB Jr: Enhancement of macrophage candidacidal activity by interferon-γ. Increased phagocytosis, killing and calcium signal mediated by a decreased number of mannose receptors J Clin Invest 1993;91:2596-2601.
41. Roilides E, Uhlig K, Venzon D, Pizzo PA, Walsh TJ: Neutrophil oxidative burst in response to blastoconidia and pseudohyphae of Candida albicans Augmentation by granulocyte colony-stimulating factor and interferon-γ. J Infect Dis 1992;166:668-673.
42. Stevenhagen A, Van Furth R: Interferon-γ activates the oxidative killing of Candida albicans by human granulocytes. Clin Exp Immunol 1993;91:170-175.
43. Djeu JY, Liu JH, Wei S, Rui H, Pearson CA, Leonard MJ, Blanchard DK: Function associated with IL-2 receptor-beta on human neutrophils. Mechanism of activation of antifungal activity against Candida albicans by IL-2. J Immunol 1993;150:960-970.
44. Beno DW, Matthews HL: Growth inhibition of Candida albicans by IL-2-activated splenocytes. Infect Immun 1992;60:853-863.
45. Treseler CB, Maziarz RT, Levitz SM: Biological activity of interleukin-2 bound to Candida albicans. Infect Immun 1992;60:183-188.
46. Pericle F, Liu JH, Diaz JI, Blanchard DK, Wei S, Forni G, Djeu JY: Interleukin-2 prevention of apoptosis in human neutrophils. Eur J Immunol 1994;24:440-444.
47. Romani L, Mocci S, Cenci E, Mencacci A, Sbaraglia G, Puccetti P, Bistoni F: Antigen-specific cytolysis of infected cells in murine candidiasis. Eur J Epidemiol 1992;8:368-376.
48. 2 enhances and gamma interferon inhibits germ tube formation in Candida albicans Infect Immun 1990;58:260-262
49. Ibrahim AS, Filler SG, Ghannoum MA, Edwards JE Jr. Interferon-γ protects endothehal cells from damage by Candida albicans. J Infect Dis 1993;167:1467-1470.
50. Qian Q, Jutila MA, Van Rooijen N, Cutler JE: Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis. J Immunol 1994;152:5000-5008.
51. Kullberg BJ, Van't Wout JW, Hoogstralen C, Van Furth R: Recombinant interferon-γ enhances resistance to acute disseminated Candida albicans infection in mice. J Infect Dis 1993;168:436-443.
52. Sher A, Coffman RL: Regulation of immunity to parasites by T cells and T cell-derived cytokines. Ann Rev Immunol 1992;10:385-409.
53. Lombardi G, DI Massimo AM, del Gallo F, Vismara D, Piccolella E, Pugliese O, Colizzi V: Mechanism of action of an antigen non-specific inhibitory factor produced by human T cells stimulated by MPPS and PPD. Cell Immunol 1986;98 434-443.
54. Lombardi G, Vismara D, Piccolella E, Colizzi V, Asherson GL: A non-specific inhibitory factor produced by Candida albicans activated T cells impairs cell proliferation by inhibiting interleukin-1 production. Clin Exp Immunol 1985;60:303-310.
55. Romani L, Mencacci A, Cenci E, Spaccapelo R, Mosci P, Puccetti P, Bistoni F: CD4+ subset expression in murine candidiasis: Th responses correlate directly with genetically determined susceptibility or vaccine-induced resistance. J Immunol 1993; 150-925-931.
56. Swain SL: IL-4 dictates T-cell differentiation. Res Immunol 1993;144:616-620.
57. Cenci E, Romani L, Mencacci A, Spaccapelo R, Schiaffella E, Puccetti P, Bistoni F: Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans Eur J Immunol 1993;23:1034-1038.
58. Powrie F, Menon S, Coffman RL: Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo Eur J Immunol 1993;23:3043-3049.
59. Terada N, Konno A, Shirotory K, Fujisawa T, Atsuta J, Ichimi R, Kikuchi Y, Takaki S, Takatsu K, Togawa K: Mechanism of eosinophil infiltration in the patient with subcutaneous angioblastic lymphoid hyperplasia with eosinophilia (Kimura's disease). Mechanism of eosinophil chemotaxis mediated by candida antigen and IL-5 Int Arch Allergy 1994,104:18-20.
60. Romani L, Mencacci A, Grohmann U, Mocci S, Mosci P, Puccetti P, Bistoni F: Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis. J Exp Med 1992;176:19-25
61. Romani L, Puccetti P, Mencacci A, Cenci E, Spaccapelo R, Tonnetti L, Grohmann U, Bistoni F: Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. J Immunol 1994;152:3514-3521.
62. Sadick MD, Heinzel FP, Holaday BJ, Pu RT, Dawkins RS, Locksley RM: Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody: Evidence for a T cell-dependent, interferon gamma-independent mechanism. J Exp Med 1990;171:115-127.
63. Chatelain R, Varkila K, Coffman RL: IL-4 induces a Th2 response in Leishmania major-infected mice. J Immunol 1993;61:4105-4111.
64. Puccetti P, Mencacci A, Cenci E, Spaccapelo R, Mosci P, Enssle K-H, Romani L, Bistoni F: Cure of murine candidiasis by recombinant soluble interleukin-4 receptor. J Infect Dis 1994;169: 1325-1331.
65. Fidel PL, Lynch ME, Redonondolopez V, Sobel JD, Robinson R: Systemic cell-mediated immune reactivity in women with recurrent vulvovaginal candidiasis. J Infect Dis 1993;168:1458-1465.
66. Torosantucci A, Bromuro C, Gomez MJ, Ausiello CM, Urbani F, Cassone A: Identification of a 65-kDa mannoprotein as a main target of human cell-mediated immune response to Candida albicans. J Infect Dis 1993;168:427-435.
67. De Bernardis F, Molinari A, Boccanera M, Stringaro A, Robert R, Senet JM, Arancia G, Cassone A: Modulation of cell surface-associated antigen expression in experimental candidal vaginitis. Infect Immun 1994;62:509-519.
68. Romani L, Puccetti P, Mencacci A, Spaccapelo R, Cenci E, Tonnetti L, Bistoni F: Tolerance to staphylococcal enterotoxin B initiates Th1 cell differentiation in mice infected with Candida albicans. Infect Immun 1994;62:4047-4053
69. Blasi E, Pitzurra L, Puliti M, Lanfrancone L, Bistoni F: Early differential molecular response of a macrophage cell line to yeast and hyphal forms of Candida albicans. Infect Immun 1992;60 832-837.
70. Allendoerfer R, Magee DM, Smith JG, Bonewald L, Graybill JR: Induction of tumor necrosis factor-α in murine Candida albicans infection. J Infect Dis 1993.167.1168-1172.
71. Ashman RB, Bolitho EM: Strain differences in the severity of lesions in murine systemic candidiasis correlate with the production of functional gamma Interferon by Candida-activated lymphocytes in vitro. Lymphokine Cytokine Res 1993;12:471-476.
72. Kaufmann SHE, Reddehase MJ: Infection of phagocytic cells. Curr Opin Immunol 1989;2:43-49.
73. Stein M, Keshav S, Harris N, Gordon S: Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation J Exp Med 1992;176:287-292.
74. Liew FY, Li Y, Severn A, Millott S, Schmidt J, Salter M, Moncada S: A possible novel pathway of regulation by murine Th2 cells of a Th1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages. Eur J Immunol 1991;21:2489-2494.
75. Bogdan C, Vodovotz Y, Nathan C: Macrophage deactivation by interleukin 10. J Exp Med 1991; 174:1549-1555.
76. Oswald IP, Wynn TA, Sher A, James SL: Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor α required as a cofactor for interferon γ-induced activation. Proc Natl Acad Sci USA 1992;89.8676-8680.
77. Louie A, Baltch AL, Smith RP, Franke MA, Ritz WA, Singh JK, Gordon MA: Tumor necrosis factor alpha has a protective role in a murine model of systemic candidiasis. Infect Immun 1994; 62 2761-2772.
78. Steinshamn S, Waage A: Tumor necrosis factor and interleukin-6 in Candida albicans infection in normal and granulocytopenic mice. Infect Immun 1992;60:4003-4008
79. Djeu JY, Blanchard DK, Halkias D, Friedman H: Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: Activation by interferon-gamma and tumor necrosis factor. J Immunol 1986;137:2980-2984.
80. Kullberg BJ, Vogels MTE, van der Meer JWM: Immunomodulators in bacterial and fungal infections. Clin Immunother 1994,1:43-55.
81. Walsh TJ, Van Cutsem J, Polak AM, Graybill JR: Immunomodulation and antifungal therapy of experimental invasive candidiasis J Med Vet Mycol 1992;30(S1):225-240.
82. Liew FY: Induction, regulation and function of T-cell subsets in leishmaniasis. Chem Immunol 1992;54:117-135.
83. Reed SG, Scott P: T-cell and cytokine responses in leishmaniasis. Curr Opin Immunol 1993;5: 524-531.
84. Seder RA, Paul WE: Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 1994;12:635-673
85. Liew FY, Li Y, Moss D, Parkinson C, Roger MV, Moncada S: Resistance to Letshmania major infection correlates with the induction of nitric synthase in macrophages. Eur J Immunol 1991;21:3009-3014
86. Romani L, Mencacci A, Tonnetti L, Spaccapelo R, Cenci E, Wolf S, Puccetti P, Bistoni F. Interleukin-12 but not interferon-γ production correlates with induction of T helper type-1 phenotype in murine candidiasis. Eur J Immunol 1994;24:909-915.
87. Garner RE, Kuruganti U, Czarniecki CW, Chiu HH, Domer JE. In vivo immune responses to Candida albicans modified by treatment with recombinant gamma interferon. Infect Immun 1989; 57:1800-1808.
88. Romani L, Mencacci A, Tonnetti L, Spaccapelo R, Cenci E, Puccetti P, Wolf SF, Bistoni F: IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis J Immunol 1994;152:5167-5175.
89. Romani L, Mencacci A, Cenci E, Spaccapelo R, Schiaffella E, Tonnetti L, Puccetti P, Bistoni F: Natural killer cells do not play a dominant role in CD4+ subset differentiation in Candida albicans-infected mice. Infect Immun 1993;61:3769-3774.
90. Kohler J, Heumann D, Garotta G, LeRoy D, Bailat S, Barras C, Baumgartner J-D, Glauser MP: IFN-γ involvement in the severity of gram-negative infections in mice. J Immunol 1993;151:916-921.
91. Seder RA, Gazzinelli R, Sher A, Paul WE: Interleukin 12 acts directly on CD4+ cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci USA 1993;90:10188-10192.
92. Scott, P: IL-12: initiation cytokine for cell-mediated immunity. Science 1993;260:496-497.
93. Chan SH, Perussia B, Gupta JW, Kobayashi M, Pospisil M, Young HA, Wolf SF, Young D, Clark SC, Trinchieri G: Induction of IFN-γ production by NK cell stimulatory factor (NKSF): characterization of the responder cells and synergy with other inducers. J Exp Med 1991;173: 869-879.
94. Heinzel FP, Rerko RM, Ling P, Hakimi J, Schoenhaut DS: Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon Infect Immun 1994;62:4244-4249.
95. Biron CA Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr Opin Immunol 1994;6:530-538.
96. Romagnani S: Induction of Th1 and Th2 responses: a key role for the 'natural' immune response? Immunol Today 1992;13:379-383.
97. Bradley LM, Duncan DD, Yoshimoto K, Swain SL: Memory effectors: A potent. IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen. J Immunol 1993; 150:3119-3130
98. Reiner SL, Locksley RM. Lessons from Leishmania: A model for investigations of CD4+ subset differentiation. Infect Agents Dis 1992;1:33-42.
99. Gollob K.J. Coffman RL: A minority subpopulation of CD4+ T cells directs the development of naive CD4+ T cells into IL-4 secreting cells. J Immunol 1994;152:5180-5188.
100. Zimmermann S, Becker-Perez I, Beuscher H-U, Kroczek RA, Röllinghoff M, Solbach W: Leishmania major parasites share an epitope with the murine CD3-T cell receptor complex. Eur J Immunol 1994;24:503-507
101. Sher A, Gazzmelli RT, Oswald IP, Clerici M, Kullberg M, Pearce EJ, Berzofsky JA, Mosmann TR, James SL, Morse HC III: Role of T-cell derived cytokines in the downregulation of immune response in parasitic and retroviral infection. Immunol Rev 1992;127:183-204
102. Mosier DE: Consequences of secondary or co-infections for immunity. Curr Opin Immunol 1944; 6:539-544.
103. Rabinovitch A: Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes 1994;43:613-621.
104. Lacour M: Acute infections in atopic dermatitis, a clue for a pathogenetic role of a Th1/Th2 imbalance? Dermatology 1994;188:255-257.
105. Savolainen J, Lammintausta K, Kahmo IC, Viander M: Candida albicans and atopic dermatitis. Clin Exp Allergy 1993;23.332-339.
106. Nagy F, Szenasi Z, Szollosy E, Kiss I, Varro V Determination and kinetics of antibody response to Candida albicans in ulcerative colitis. Hepatogastroenterology 1989;36:182-184.
107. Mencacci A, Romani L, Mosci P, Cenci E, Tonnetti L, Vecchiarelli A, Bistoni F: Low-dose streptozotocin-induced diabetes in mice. II. Susceptibility to Candida albicans infection correlates with the induction of a biased Th2-like antifungal response. Cell Immunol 1993;150:36-44.
108. Cassone A, Palma C, Djeu JY, Aiuti F, Quinti I: Anticandidal activity and interleukin-1β and interleukin-6 production by polymorphonuclear leukocytes are preserved in subjects with AIDS. J Clin Microbiol 1993.31:354-357
109. Imam N, Carpenter CJ, Mayer KH, Fisher A, Stein M, Dauforth SB. Hierarchical pattern of mucosal Candida infection in HIV-seropositive women. Am J Med 1990;89:142-146.
110. Coogan MM, Sweet SP, Challacombe SJ: Immunoglobulin A (IgA), IgA1. and IgA2 antibodies to Candida albicans in whole and parotid saliva in immunodeficiency virus infection and AIDS. Infect Immun 1994;62:892-896.
111. McCarthy GM: Host factors associated with HIV-related oral candidiasis: A review Oral Surg Oral Med Oral Pathol 1992;73:181-186.
112. Pantaleo G, Graziosi ,. Fauci AS: The immuaopathogenesis of human immunodeficiency virus infection. N Engl J Med 1993;328:327-335.
113. Mosmann T: Cytokine patterns during the progression to AIDS Science 1994;265:193-194.
114. Clerici M, Shearer GM: A Th1 to Th2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993;14:107-111.
115. Romagnani S, Maggi E: Th1 versus Th2 responses in AIDS. Curr Opin Immunol 1994;4:616-622.
116. Graziosi C, Pantaleo G, Gantt KR, Fortin J-P, Demarest JF, Cohen OJ, Sékaly RP, Fauci AS: Lack of evidence for the dichotomy of Th1 and Th2 predominance in HIV-infected individuals Science 1994,265:248-252.
117. Clerici M, Lucey DR, Berzofsky JA, Pinto LA, Wynn TA, Blatt SP, Dolan MJ, Hendrix CW, Wolf SF, Shearer GM. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro Science 1993;262.1721-1724.
118. Cole GT, Saha K, Seshan KR, Lynn KT, Franco M, Wong PKY. Retrovirus-induced immunodeficiency in mice exacerbates gastrointestinal candidiasis. Infect Immun 1992;60:4168-4178.
119. Yamamoto Y, Specter S, Friedman H: Lipopolysaccharide restores anti-Candida albicans growth inhibition activity of polymorphonuclear neutrophils from retrovirus-immunosuppressed mice. Infect Immun 1993;61-2216-2219.
120. Rigg D. Miller MM, Metzger WJ: Recurrent allergic vulvovagiintis: Treatment with Candida albicans allergen immunotherapy, Am J Obstet Gynecol 1990;162:332-336.
121. Pedersen M, Permin H, Norn S, Skov PS: Determination of immunoglobulins responsible for histamine release induced by microbial antigens in AIDS patients. Allergy 1989;44:460-466.
122. Kalo-Klein A, Witkin SS: Candida albicans. Cellular immune system interactions during different stages of the menstrual cycle. Am J Obstet Gynecol 1989;161:1132-1136.
123. Fidel PL Jr, Sobel JD: The role of cell-mediated immunity in candidiasis Trends Microbiol 1994; 2:202-206.
124. Sheffer AL. Allergen-specific immunotherapy: A role for T-cell Anergy. Ann Allergy 1993;71: 327-329.