Immunoregulation by interleukin-12

Journal of Leukocyte Biology

Volumn 59, Issue 4, 1996, Pages 505-511

  Trinchieri, Giorgio ^a   Gerosa, Franca ^a,b  

^a WISTAR INSTITUTE   (United States)

^b POLICLINICO BORGO ROMA   (Italy)

Author keywords

Interferon ; Phagocytes; Th1 cells

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; NITROUS OXIDE;

ANTIGEN PRESENTING CELL; HELPER CELL; HUMAN; IMMUNOREGULATION; NATURAL KILLER CELL; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW;

EID: 0029973242     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.59.4.505     Document Type: Review

References (51)

1. Kobayashi, M., Fitz, L., Ryan, M., Hewick, R. M., Clark, S. C., Chan, S., Loudon, R., Sherman, F., Perussia, B., Trinchieri, G. (1989) Identification and purification of Natural Killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170, 827-846.
2. Stern, A. S., Podlaski, F. J., Hulmes, J. D., Pan, Y. E., Quinn, P. M., Wolitzky, A. G., Familletti, P. C., Stremlo, D. L., Truitt, T., Chizzonite, R., Gately, M. K. (1990) Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 87, 6808-6812.
3. Wolf, S. F., Temple, P. A., Kobayashi, M., Young, D., Dicig, M., Lowe, L., Dzialo, R., Fitz, L., Ferenz, C., Hewick, R. M., Kelleher, K., Herrmann, S. H., Clark, S. C., Azzoni, L., Chan, S. H., Trinchieri, G., Perussia, B. (1991) Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and Natural Killer cells. J. Immunol. 146, 3074-3081.
4. Gubler, U., Chua, A. O., Schoenhaut, D. S., Dwyer, C. M., McComas, W., Motyka, R., Nabavi, N., Wolitzky, A. G., Quinn, P. M., Familletti, P. C., Gately, M. K. (1991) Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 88, 4143-4147.
5. Schoenhaut, D. S., Chua, A. O., Wolitzky, A. G., Quinn, P. M., Dwyer, C. M., McComas, W., Familletti, P. C., Gately, M. K., Gubler, U. (1992) Cloning and expression of murine IL-12. J. Immunol. 148, 3433-3440.
6. Sieburth, D., Jabs, E. W., Warrington, J. A., Li, X., Lasota, J., LaForgia, S., Kelleher, K., Huebner, K., Wasmuth, J. J., Wolf, S. F. (1992) Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics 14, 59-62.
7. D'Andrea, A., Rengaraju, M., Valiante, N. M., Chehimi, J., Kubin, M., Aste-Amezaga, M., Chan, S. H., Kobayashi, M., Young, D., Nickbarg, E., Chizzonite, R., Wolf, S. F., Trinchieri, G. (1992) Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J. Exp. Med. 176, 1387-1398.
8. Kubin, M., Chow, J. M., Trinchieri, G. (1994) Differential regulation of interleukin-12 (IL-12), tumor necrosis factor-α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood 83, 1847-1855.
9. Merberg, D. M., Wolf, S. F., Clark, S. C. (1992) Sequence similarity between NKSF and the IL-6/G-CSF family. Immunol. Today 13, 77-78.
10. Gearing, D. P., Cosman, D. (1991) Homology of the p40 subunit of Natural Killer cell Stimulatory Factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell 66, 9-10.
11. Chua, A. O., Chizzonite, R., Desai, B. B., Truitt, T. P., Nunes, P., Minetti, L. J., Warrier, R. R., Presky, D. H., Levine, S. F., Gately, M. K., Gubler, U. (1994) Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. J. Immunol. 153, 128-136.
12. Presky, D. H., Gubler, U., Chizzonite, R. A., Gately, M. K. (1995) IL-12 receptors and receptor antagonists. Res. Immunol. in press.
13. Cassatella, M. A., Meda, L., Gasperini, S., D'Andrea, A., Ma, X., Trinchieri, G. (1995) Interleukin-12 production by human polymorphonuclear leukocytes. Eur. J. Immunol. 25, 1-5.
14. + T cells. J. Immunol. 154, 5071-5079.
15. Tripp, C. S., Wolf, S. F., Unanue, E. R. (1993) Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90, 3725-3729.
16. Gazzinelli, R. T., Wysocka, M., Hayashi, S., Deukers, E. Y., Hieny, S., Caspar, P., Trinchieri, G., Sher, A. (1994) Parasite induced IL-12 stimulates early TFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153, 2533-2543.
17. Vieira, L. Q., Hondowicz, B. D., Afonso, L. C. C., Wysocka, M., Trinchieri, G., Scott, P. (1994) Infection with Leishmania major induces interleukin-12 production in vivo. Immunol. Lett. 40, 157-161.
18. Hyjek, E., Lischner, H. W., Hyslop, T., Bartkowiak, J., Kubin, M., Trinchieri, C., Kozbor, D. (1995) Cytokine patterns during progression to AIDS in children with perinatal HIV infection. J. Immunol. 155, 4060-4071.
19. D'Andrea, A., Aste-Amezaga, M., Valiante, N. M., Ma, X., Kubin, M., Trinchieri, G. (1993) Interleukin-10 inhibits human lymphocyte IFN-γ production by suppressing natural killer cell stimulatory factor/interleukin-12 synthesis in accessory cells. J. Exp. Med. 178, 1041-1048.
20. Mattner, F., Fischer, S., Guckes, S., Jin, S., Kaulen, H., Schmitt, E., Rüde, E., Germann, T. (1993) The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 23, 2202-2208.
21. Ling, P., Gately, M. K., Gubler, U., Stern, A. S., Lin, P., Hollfelder, K., Su, C., Pan, Y. C., Hakimi, J. (1995) Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J. Immunol. 154, 116-127.
22. Chua, A. O., Wilkinson, V. L., Presky, D. H., Gubler, U. (1995) Cloning and characterization of a mouse IL-12 receptor-β component. J. Immunol. 155, 4286-4294.
23. Ma, X., Chow, J. M., Gri, G., Carra, G., Gerosa, F., Wolf, S. F., Dzialo, R., Trinchieri, G. (1995) The interleukin-12 p40 gene promoter is primed by interferon-γ in monocytic cells. J. Exp. Med., in press.
24. Murphy, K. M., Szabo, S. J., Cleveland, M. G., Jacobson, N. G., Gubler, U., Magram, J., Murphy, T. L. (1995) Regulation of the IL-12 p40 gene and IL-12 receptor signaling pathway in T cell development. IL-12 in infection, prospects for prophylactic and therapeutic intervention, Bethesda, MD, May 15-17 (meeting abstract).
25. Murphy, E. E., Terres, G., Macatonia, S. E., Hsieh, C., Mattson, J., Lanier, L., Wysocka, M., Trinchieri, G., Murphy, K., O'Garra, A. (1994) B7 and IL-12 cooperate for proliferation and IFN-γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180, 223-231.
26. Hayes, M. P., Wang, J., Norcross, M. A. (1995) Regulation of interleukin-12 expression in human monocytes: selective priming by IFN-γ of LPS-inducible p35 and p40 genes. Blood 86, 646-650.
27. Gately, M. K., Wolitzky, A. G., Quinn, P. M., Chizzonite, R. (1992) Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell. Immunol. 143, 127-142.
28. Chan, S. H., Perussia, B., Gupta, J. W., Kobayashi, M., Pospísil, M., Young, H. A., Wolf, S. F., Young, D., Clark, S. C., Trinchieri, G. (1991) Induction of IFN-γ production by NK cell stimulatory factor (NKSF): Characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173, 869-879.
29. Chan, S. H., Kobayashi, M., Santoli, D., Perussia, B., Trinchieri, G. (1992) Mechanisms of IFN-γ induction by natural killer cell stimulatory factor (NKSF/IL-12): Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2. J. Immunol. 148, 92-98.
30. Perussia, B., Chan, S., D'Andrea, A., Tsuji, K., Santoli, D., Pospisil, M., Young, D., Wolf, S., Trinchieri, G. (1992) Natural killer cell stimulatory factor or IL-12 has differential effects on the proliferation of TCRαβ+,TCRγδ+ T lymphocytes and NK cells. J. Immunol. 149, 3495-3502.
31. Chehimi, J., Valiante, N. M., D'Andrea, A., Rengaraju, M., Rosado, Z., Kobayashi, M., Perussia, B., Wolf, S., Starr, S. E., Trinchieri, G. (1993) Enhancing effect of natural killer cell stimulatory factor (NKSF/IL-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells. Eur. J. Immunol. 23, 1826-1830.
32. Jacobsen, S. E., Veiby, O. P., Smeland, E. B. (1993) Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells. J. Exp. Med. 178, 413-418.
33. Bellone, G., Trinchieri, G. (1994) Dual stimulatory and inhibitory effect of NK cell stimulatory factor/IL-12 on human hematopoiesis. J. Immunol. 153, 930-937.
34. Eng, V. M., Car, B. D., Schnyder, B., Lorenz, M., Lugli, S., Aguet, M., Anderson, T. D., Ryffel, B., Quesniaux, V. F. J. (1995) The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo. J. Exp. Med. 181, 1893-1898.
35. Wysocka, M., Kuban, M., Vieira, L. Q., Ozmen, L., Garotta, G., Scott, P., Trinchieri, G. (1995) Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25, 672-676.
36. + T cells during initiation of infection. J. Exp. Med. 179, 447-456.
37. Flesch, I. E. A., Hess, J. H., Huang, S., Aguet, M., Rothe, J., Bluethmann, H., Kaufmann, S. H. E. (1995) Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α. J. Exp. Med. 181, 1615-1621.
38. Biron, C. A., Orange, J. S. (1995) IL-12 in acute viral infectious disease. Res. Immunol., in press.
39. D'Andrea, A., Ma, X., Aste-Amezaga, M., Paganin, C., Trinchieri, G. (1995) Stimulatory and inhibitory effects of IL-4 and IL-13 on production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and TNF-α production. J. Exp. Med. 181, 537-546.
40. Kubin, M., Kamoun, M., Trinchieri, G. (1994) Interleukin-12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180, 211-222.
41. Manetti, R., Parronchi, P., Giudizi, M. G., Piccinni, M-P., Maggi, E., Trinchieri, G., Rumagnani, S. (1993) Natural killer cell stimulatory factor (NKSF/IL-12) induces Th1-type specific immune responses and inhibits the development of IL-4 producing Th cells. J. Exp. Med. 177, 1199-1204.
42. Manetti, R., Gerosa, F., Giudizi, M. G., Biagiotti, R., Parronchi, P., Piccinni, M., Sampognaro, S., Maggi, E., Romagnani, S., Trinchieri, G. (1994) Interleukin-12 induces stable priming for interferon-γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J. Exp. Med. 179, 1273-1283.
43. + T cells occurs through macrophage production of IL-12. Science 260, 547-549.
44. Heinzel, F. P., Schoenhaut, D. S., Rerko, R. M., Rosser, L. E., Gately, M. K. (1993) Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177, 1505-1509.
45. H1 cells. Immunol. Today 14, 335-338.
46. Nabors, G. S., Afonso, L. C., Farrell, J. P., Scott, P. (1995) Switch from a type 2 to a type 1T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. Proc. Natl. Acad. Sci. USA 92, 3142-3146.
47. Afonso, L. C. C., Scharton, T. M., Vieira, L. Q., Wysocka, M., Trinchieri, G., Scott, P. (1994) The adjuvant effect of interleukin-12 in a vaccine against Leishmama major. Science 263, 235-237.
48. + T cells activated in a T helper type 2-like response in vivo. Eur. J. Immunol. 25, 1168-1175.
49. Kelso, A. (1995) Th1 and Th2 subsets: paradigms lost? Immunol. Today 16, 374-379.
50. - lymphocyte subpopulation. J. Immunol. 154, 4294-4301.
51. Picker, L. J., Singh, M. K., Zdraveski, Z., Treer, J. R., Waldrop, S. L., Bergstresser, P. R., Maino, V. C. (1995) Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood 86, 1408-1419.