Type 1 and Type 2: A fundamental dichotomy for all T-cell subsets

Current Opinion in Immunology

Volumn 8, Issue 3, 1996, Pages 336-342

  Carter, Laura L ^a   Dutton, Richard W ^a  

^a TRUDEAU INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CYTOKINE; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

REVIEW; T LYMPHOCYTE SUBPOPULATION;

EID: 0030175602     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80122-1     Document Type: Article

References (73)

1. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 7:1989;145-173.
2. + T cells. of special interest Annu Rev Immunol. 12:1994;635-673 A key review of the properties of T helper subsets and the factors that control their development.
3. Swain SL, Croft M, Dubey C, Haynes L, Rogers P, Zhang X, Bradley LM. From naive to memory T cells. Immunol Rev. 1996;. in press.
4. Sher A, Coffman RL. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu Rev Immunol. 10:1992;385-409.
5. Reiner SL, Locksley RM. The regulation of immunity to Leishmania major. of special interest Annu Rev Immunol. 13:1995;151-177 An excellent review of the role of Th subsets in determining resistance and susceptibility to disease.
6. Romagnani S. Lymphokine production by human T cells in disease states. of special interest Annu Rev Immunol. 12:1994;227-257 A comprehensive review of human T cell subsets in disease.
7. Modlin RL, Nutman TB. Type 2 cytokines and negative immune regulation in human infections. of special interest Curr Opin Immunol. 5:1993;511-517 Review of effects of Type 2 responses in human disease.
8. Clerici M, Shearer GM. The Th1-Th2 hypothesis of HIV infection: new insights. Immunol Today. 15:1994;575-581.
9. Reiner SL, Seder RA. T helper cell differentiation in immune response. of special interest Curr Opin Immunol. 7:1995;360-366 Recent review of the role of T helper cells in directing the immune response.
10. + T lymphocytes. J Immunol. 129:1982;1076-1079.
11. Glasebrook AL, Kelso A, MacDonald HR. Cytolytic T lymphocyte clones that proliferate autonomously to specific alloantigenic stimulation. II. Relationship of the Lyt-2 molecular complex to cytolytic activity, proliferation, and lymphokine secretion. J Immunol. 130:1983;1545-1551.
12. Andrus L, Granelli-Piperno A, Reich E. Cytotoxic T cells both produce and respond to interleukin 2. J Exp Med. 159:1984;647-652.
13. + cytolytic clones. Eur J Immunol. 14:1984;1066-1069.
14. + T cell clones. J Immunol. 141:1988;849-855.
15. + and their role in the generation of antigen-specific cytotoxic T cells. Eur J Immunol. 21:1991;1863-1871.
16. + T cell clones secrete the Th1 pattern of cytokines. J Immunol. 144:1990;1744-1752.
17. Widmer MB, Acres RB, Sassenfeld HM, Grabstein KH. Regulation of cytolytic cell populations from human peripheral blood by B cell stimulatory factor 1 (interleukin 4). J Exp Med. 166:1987;1447-1455.
18. Pfeifer JD, McKenzie DT, Swain SL, Dutton RW. B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors. J Exp Med. 166:1987;1464-1470.
19. + T cells can be primed in vitro to produce IL-4. J Immunol. 148:1992;1652-1656.
20. Erard F, Wild MT, Garcia-Sanz JA, Le Gros G. Switch of CD8 T cells to noncytolytic CD8-CD4- cells that make TH2 cytokines and help B cells. Science. 260:1993;1802-1805.
21. + T cells.
22. Manetti R, Gerosa F, Giudizi MG, Biagiotti R, Parronchi P, Piccinni MP, Sampognaro S, Maggi E, Romagnani S, Trinchieri G, et al. Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones. J Exp Med. 179:1994;1273-1283.
23. Chouaib S, Chehimi J, Bani L, Genetet N, Tursz T, Gay F, Trinchieri G, Mami-Chouaib F. Interleukin 12 induces the differentiation of major histocompatibility complex class I-primed cytotoxic T-lymphocyte precursors into allospecific cytotoxic effectors. Proc Natl Acad Sci USA. 91:1994;12659-12663.
24. + T cells and the mechanisms involved.
25. + T-cell subsets, including an analysis of polarization stability of clones.
26. + T cells mediating cognate help.
27. + populations in the rat.
28. Byun DG, Demeure CE, Yang LP, Shu U, Ishihara H, Vezzio N, Gately MK, Delespesse G. In vitro maturation of neonatal human CD8 T lymphocytes into IL-4 and IL-5-producing cells. of special interest J Immunol. 153:1994;4862-4871 Describes in vitro polarization of T cell subsets from human umbilical cord blood.
29. Biron CA. Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr Opin Immunol. 6:1994;530-538.
30. + and CD8 T cell clones. Science. 254:1991;279-282.
31. Anderson GP, Coyle AJ. TH2 and 'TH2-like' cells in allergy and asthma: pharmacological perspectives. Trends Pharmacol Sci. 15:1994;324-332.
32. + T cells in allergic reactions.
33. + T cells.
34. Chehimi J, Starr SE, Frank I, D'Andrea A, Ma X, MacGregor RR, Sennelier J, Trinchieri G. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J Exp Med. 179:1994;1361-1366.
35. Barcellini W, Rizzardi GP, Borghi MO, Fain C, Lazzarin A, Meroni PL. TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients. AIDS. 8:1994;757-762.
36. Navikas V, Link J, Wahren B, Persson C, Link H. Increased levels of interferon-gamma (IFN-gamma), IL-4 and transforming growth factor-beta (TGF-beta) mRNA expressing blood mononuclear cells in human HIV infection. Clin Exp Immunol. 96:1994;59-63.
37. + T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection. J Exp Med. 180:1994;489-495.
38. + cell response against human immunodeficiency virus: implications for long-term survival. Proc Natl Acad Sci USA. 92:1995;11135-11139.
39. Clerici M, Sarin A, Coffman RL, Wynn TA, Blatt SP, Hendrix CW, Wolf SF, Shearer GM, Henkart PA. Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis. Proc Natl Acad Sci USA. 91:1994;11811-11815.
40. + T cells. Science. 270:1995;1811-1815.
41. + T cells that secrete IFN-gamma and IL-5. J Immunol. 145:1990;68-77.
42. + memory T cells secrete T helper type 1 and type 2 cytokines and provide help for immunoglobulin secretion. Eur J Immunol. 24:1994;3087-3092.
43. + T cells of Th1 and Th2 type in salivary gland-associated tissues. Eur J Immunol. 24:1994;2653-2658.
44. Weiner HL, Friedman A, Miller A, Khoury SJ, al-Sabbagh A, Santos L, Sayegh M, Nussenblatt RB, Trentham DE, Hafler DA. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol. 12:1994;809-837.
45. + donor T cells fail to induce experimental acute graft-versus-host disease. of outstanding interest J Immunol. 155:1995;585-593 Discusses the role of T cell subsets in GVH responses.
46. + and anti-CD8 monoclonal antibodies on the development of experimental systemic lupus erythematosus in mice. Cellular Immunology. 167:1996;30-37.
47. Kikutani H, Makino S. The murine autoimmune diabetes model: NOD and related strains. Adv Immunol. 51:1992;285-322.
48. Von Herrath MG, Dockter J, Oldstone MB. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity. 1:1994;231-242.
49. + T cells in vivo.
50. Ferrick DA, Schrenzel MD, Mulvania T, Hsieh B, Ferlin WG, Lepper H. Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. of outstanding interest Nature. 373:1995;255-257 A ground-breaking paper describing the generation in vivo of Type 1 and Type 2 γδ T cells, as assessed by intracellular cytokine staining.
51. Hsieh B, Schrenzel MD, Mulvania T, Lepper HD, DiMolfetto-Landon L, Ferrick DA. In vivo cytokine production in murine listeriosis. J Immunol. 156:1996;232-237.
52. Subauste CS, Chung JY, Do D, Koniaris AH, Hunter CA, Montoya JG, Porcelli S, Remington JS. Preferential activation and expansion of human peripheral blood γδ T cells in response to Toxoplasma gondii in vitro and their cytokine production and cytotoxic activity against T. gondii-infected cells. J Clin Invest. 96:1995;610-619.
53. + T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response. J Immunol. 155:1995;45-57.
54. + T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J Exp Med. 182:1995;1579-1584.
55. + T cells. J Immunol. 154:1995;1684-1690.
56. Del Prete G, De Carli M, D'Elios MM, Daniel KC, Almerigogna F, Alderson M, Smith CA, Thomas E, Romagnani S. CD30-mediated signaling promotes the development of human T helper type 2-like T cells. J Exp Med. 182:1995;1655-1661.
57. Bowen MA, Lee RK, Miragliotta G, Nam SY, Podack ER. Structure and expression of murine CD30 and its role in cytokine production. J Immunol. 156:1996;442-449.
58. Biron CA, Gazzinelli RT. Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. of special interest Curr Opin Immunol. 7:1995;485-496 Discusses the possibilities of manipulating subset responses in therapy.
59. Bendelac A. Mouse NK1+ T cells. Curr Opin Immunol. 7:1995;367-374.
60. Porcelli SA, Modlin RL. CD1 and the expanding universe of T cell antigens. J Immunol. 155:1995;3709-3710.
61. + T cells in the generation of Type 2 responses is suggested.
62. Swain SL. Generation and in vivo persistence of polarized Th1 and Th2 memory cells. Immunity. 1:1994;543-552.
63. Mocci S, Coffman RL. Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4. J Immunol. 154:1995;3779-3787.
64. Bradley LM, Yoshimoto K, Swain SL. The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J Immunol. 155:1995;1713-1724.
65. Szabo SJ, Jacobson NG, Dighe AS, Gubler U, Murphy KM. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. of special interest Immunity. 2:1995;665-675 A first description of the molecular mechanisms involved in Type 1/Type 2 subset differentiation.
66. Croft M, Swain SL. Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. J Immunol. 154:1995;4269-4282.
67. Kelso A. Th1 and Th2 subsets: paradigms lost? of outstanding interest Immunol Today. 16:1995;374-379 Raises a caveat to the otherwise exuberant embrace of the Type 1/Type 2 paradigm.
68. + T cells and clones activated in vivo and in vitro. Immunol Rev. 123:1991;85-114.
69. Street NE, Schumacher JH, Fong TA, Bass H, Fiorentino DF, Leverah JA, Mosmann TR. Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells. J Immunol. 144:1990;1629-1639.
70. Bucy RP, Panoskaltsis-Mortari A, Huang GQ, Li J, Karr L, Ross M, Russell JH, Murphy KM, Weaver CT. Heterogeneity of single cell cytokine gene expression in clonal T cell populations. J Exp Med. 180:1994;1251-1262.
71. Assenmacher M, Schmitz J, Radbruch A. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-gamma and in interleukin-4-expressing cells. Eur J Immunol. 24:1994;1097-1101.
72. +CD27-lymphocyte subpopulation. J Immunol. 154:1995;4294-4301.
73. + cells but also reveals existence of intermediate patterns.