CD4+ T-helper-cell responses in mice with low-level Candida albicans infection

Infection and Immunity

Volumn 64, Issue 12, 1996, Pages 4907-4914

  Mencacci, Antonella ^a   Spaccapelo, Roberta ^a   Del Sero, Giuseppe ^a   Enssle, Karl Heinz ^b   Cassone, Antonio ^c   Bistoni, Francesco ^a   Romani, Luigina ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c Behringwerke AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CONTROLLED STUDY; FEMALE; HELPER CELL; INFECTION CONTROL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0029849196     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.12.4907-4914.1996     Document Type: Article

References (46)

1. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54-60.
2. Ashman, R. B., E. M. Bolitho, and A. Fulurija, 1995. Cytokine mRNA in brain tissue from mice that show strain-dependent differences in the severity of lesions induced by systemic infection wilh Candida albicans yeast. J. Infect. Dis. 172:823-830.
3. Bancroft, A. J., K. J. Else, and R. K. Grencis. 1995. Low-level infection with Trichuris muris significantly affects the polarization of the CD4 response. Eur. J. Immunol. 24:3113-3118.
4. + effector T cells in vivo: immunization results in a transient population of Mel-14 , CD45RB helper cells that secrete interlcukin 2 (IL-2). IL-3, IL-4 and Interferon γ J. Exp. Med. 174: 547-559.
5. Bradley, M. L., D. D. Duncan, K. Yoshimoto, and S. Swain. 1993. Memory effectors: a potent, IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen. J. Immunol. 150:3119-3130.
6. Bretscher, B. A., G. Wu, N. Menon, and H. Ohmann. 1992. Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science 257:539-542.
7. Brookes, B., K. Chapman, J. Lawry, A. Meager, and R. C. Rees, 1990. Suppression of lymphokine-activated killer (LAK) cell induction mediated by imerleukin-4 and transforming growth factor-alpha and Interferon-gamma, and measurement of their endogenous production. Clin. Exp. Immunol, 82:583-589.
8. Bucy, R. P., A. Panoskaltsis-Mortari, J. G.-Q. Huang, J. Li. L. Karr, M. Ross, J. H. Russel, K. M. Murphy, and C. T. Weaver. 1994. Heterogeneity of single cell cytokine gene expression in clonal T cell populations. J. Exp. Med. 180:1251-1262.
9. Burstein, H. J., and A. K. Abbas. 1993. In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen. J. Exp. Med, 177:457-463.
10. Carballido, J. M., N. Carballido-Perrig, G. Terres, C. H. Heusser, and K. Blaser, 1992. Bee venom phospholipase A2 specific T cell clones from human allergic and non-allergic individuals: cytokine patterns change in response to the antigen concentration. Eur. J. Immunol. 22:1357-1363.
11. Cenci, E., A. Mencacci, R. Spaccapelo, L. Tonnetti, P. Mosel, K.-H. Enssle, L. Romani, and F. Bistoni. 1995. T helper cell type I (Th l)- and Th2-like responses are present in mice with gastric candidiasis hut protective immunity is associated with Th l development. J. Infect. Dis. 171:1279-1288.
12. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
13. + T cells. J. Exp. Med. 182:1591-1596.
14. Critchfield, J. M., M. K. Racke, J. C. Zuniga-Pflucker, C. S. Raine, J. Goverman, and M. J. Lenardo. 1994. T cell depletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263:1139-1143.
15. D'Andrea, A., X. Ma, M. Aste-Amezaga, C. Paganin, and G. Trinchieri. 1995. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor a production. J. Exp. Med. 181:537-546.
16. Ebina, N., D. Gallardo, H. Shau, and S. H. Golub. 1990. IL-1 and IL-4 as reciprocal regulators of IL-2 induced lymphocyte cytotoxicity. Br. J. Cancer 62:619-623.
17. Essery, G., M. Feldmann, and J. R. Lamb. 1988. lnterleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes. Immunology 64:413-417.
18. Gallagher, G., K. Wilcox, and F. Al-Azzawi. 1988. Interleukin-3 and interlcukin-4 each strongly inhibit the induction and function of human LAK cells. Clin, Exp. Immunol. 74:166-170.
19. Grossman, Z., and W. E. Paul. 1992. Adoptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses. Proc, Natl. Acad. Sci. USA 89:10365-10369.
20. Heinzel, F. P., R. M. Rerko, F. Hatam, and R. M. Locksley. 1991 IL-2 is necessary for the progression of Ieishmaniasis in susceptible murine host. J. Immunol. 150:3924-3931.
21. + T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J. Exp. Med. 182:1579-1584.
22. Lezama-Davila, C. M., D. M. Williams, G. Gailagher, and J. Alexander. 1992. Cytokine control of Leishmania infection in the BALB/c mouse: enhancement and inhibition of parasite growth by local administration of IL-2 or IL-4 is species and time dependent. Parasite Immunol. 14:37-48.
23. Mencacel, A., A. Torosantucci, R. Spaccapelo, L. Romani, F. Bistoni, and A. Cassone. 1994. A mannoprotein constituent of Candida albicans that elicits different levels of delayed-type hypersensitivity, cytokine production, and anticandidal protection in mice. Infect. Immun. 62:5353-5.160.
24. Nabors, G. S., L. C. Afonso, J. P. Farrel, and P. Scott. 1995. Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. Proc. Natl. Acad. Sci. USA 92:3142-3146.
25. Orme, M., A. D. Roberts, J. P. Griffin, and J. S. Abrams. 1993. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J. Immunol. 151:510-525.
26. Parish, C. R. 1972. The relationship between humoral and cell-mediated immunity. Transplant. Rev. 13:35-65.
27. + T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med. 179:589-600.
28. Puccetti, P., A. Mencacci, E. Cenci, R. Spaccapelo, P. Mosci, K.-H. Enssle, L. Romanl, and F. Bistoni. 1994. Cure of murine candidiasis by recombinant soluble interleukin-4 receptor. J. Infect. Dis. 169:1325-1331.
29. Puccetti, P., L. Romani, and F. Bistoni, 1995. A Thl-Th2-like switch in candidiasis: new perspectives for therapy. Trends Microbiol. 3:237-240.
30. + subset expression in murine candidiasis. Infect. Immun. 60:4950-4952.
31. Romani, L., and D. H. Howard. 1995. Mechanisms of resistance to fungal infections. Curr. Opin, Immunol. 7:517-523.
32. Romani, L. A. Mencacci, E. Cenci, P. Mosci, G. Vitellozzi, U. Grohmann, P. Puccetti, and F. Bistoni. 1992. Course of primary candidiasis in T-cell depleted mice infected with attenuated variant cells. J. Infect. Dis. 166:1384-1392.
33. + subset expression in murine candidiasis. Th responses correlate directly with genetically determined susceptibility or vaccine-induced resistance. J. Immunol. 150:925-931.
34. Romani, L., A. Mencacci, U. Grohmann, S. Mocci, P. Mosci, P. Puccetti, and F. Bistoni. 1992. Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis. J. Exp. Med. 176:19-25.
35. Romani, L., A. Mencacci, L. Tonnetti, R. Spaccapelo, E. Cencl, P. Puccetti, S. F. Wolf, and F. Bistoni. 1994. IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis, J. Immunol. 152: 5167-5175.
36. Romani, L. A. Mencacci, L. Tonnetti, R. Spaccapelo, E. Cenci, S. Wolf, P. Puccetti, and F. Bistoni. 1994. lnterleukin-12 but not interferon-γ production correlates with induction of T helper type-1 phenolype in murine candidiasis, Eur. J. Immunol. 24:909-915.
37. Romanl, L., S. Mocci, C. Bletta, L. Lanfoloni, P. Puccelti, and F. Bistoni. 1991. Thl and Th2 cytokine secretion patterns in murine candidiasis: association of Thl responses with acquired resistance. Infect. Immun. 59:4647-4654.
38. Romanl, L., P. Puccetti, and F. Bistoni. 1996. Biological role of helper T-cell subsets in candidiasis. Chem. Immunol. 63:115-137.
39. Romanl, L., P. Puccetti, A. Mencacci, E. Cenci, R. Spaccapelo, L. Tonnetti, U. Grohmann, and F. Bistoni. 1994. Neutralization of 1L-10 upregulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. J. Immunol. 152:3514-3521.
40. Saiki, R. K., S. Scharf, F. Faloona, K. B. Mullis, G. T. Horn, H. A. Erlich, and N. Arnheim. 1985. Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230:1350-1354.
41. Schurmans, S., C. H. Heusser, H.-Y. Qin. J. Merino, and P. H. Lambert. 1990. In vivo effects of anti-lL-4 monoclonal antibody on neonatal induction of tolerance and on an associated autoimmune syndrome. J. Immunol. 145: 2465-2473.
42. + T cells from allergic individuals is modulated by antigen concentration and antigen presenting cell type. J. Exp. Med, 181:1081-1089.
43. + T cells, Annu. Rev. Immunol. 12:635-673.
44. Spaccapelo, R., L. Romani, L. Tonnetti, E. Cenci, A. Mencacci, G. Del Sero, R. Tognellini, S. G. Reed, P. Fuccetti, and F. Bistoni. 1995. TGF-β is important in determining the in vivo patterns of susceptibility or resistance in mice infected with Candida albicans. J. Immunol. 155:1349-1369.
45. Tonnetti, L. R. Spaccapelo, E. Cenci, A. Mencacci, P. Puccelti, R. L. Coff- man, F. Bistoni, and L. Romani. 1995. lnterleukin-4 and -10 exacerbate candidiasis in mice. Eur. J. Immunol. 25:1559-1565.
46. Wang, Z.-E., S. Zheng, D. B. Carry, D. K. Dalton. R. A. Seder, S. L. Reiner, and R. M. Locksley. 1994. Interferon γ-independent effects of interleukin 12 administered during acute or established infection due to Lieshmania major, Proc. Natl. Acad. Sci. USA 91:12932-12936.