Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: Requirement of gamma interferon for IL-12 secretion

Journal of Virology

Volumn 70, Issue 6, 1996, Pages 4121-4124

  Fantuzzi, Laura ^a   Gessani, Sandra ^a   Borghi, Paola ^a   Varano, Barbara ^a   Conti, Lucia ^a   Puddu, Patrizia ^a   Belardelli, Filippo ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLYCOPROTEIN GP 120; INTERLEUKIN 12;

ANTIVIRAL ACTIVITY; ARTICLE; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; VIRUS CELL INTERACTION;

EID: 0029970931     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.6.4121-4124.1996     Document Type: Article

References (21)

1. Borghi, P., L. Fantuzzi, B. Varano, S. Gessani, P. Puddu, L. Conti, M. R. Capobianchi, F. Ameglio, and F. Belardelli. 1995. Induction of interleukin-10 by human immunodeficiency virus type 1 and its gp120 protein in human monocytes/macrophages. J. Virol. 69:1284-1287.
2. Chehimi, J., S. E. Stair, I. Frank, A. D'Andrea, X. Ma, R. R. MacGregor, J. Sennelier, and G. Trinchieri. 1994. Impaired interleukin-12 production in human immunodeficiency virus-infected patients. J. Exp. Med. 179:1361-1366.
3. Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rytter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299.
4. Clerici, M., D. R. Lucey, J. A. Berzofsky, L. A. Pinto, T. A. Wynn, S. P. Blatt, M. J. Dolan, C. X. Hendrix, S. F. Wolf, and G. M. Shearer. 1993. Restoration of HIV-1 specific cell-mediated immune responses by interleukin-12 in vitro. Science 262:1721-1724.
5. H2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14:107-111.
6. Denis, M., and E. Ghadirian. 1994. Dysregulation of interleukin 8, interleukin 10, and interleukin 12 release by alveolar macrophages from HIV type 1-infected subjects. AIDS Res. Hum. Retroviruses 10:1619-1627.
7. Fauci, A. S. 1988. The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. Science 239:617-622.
8. Flesch, I. E. A., J. H. Hess, S. Huang, M. Aguet, J. Rothem, H. Bluethmann, and S. H. E. Kaufmann. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon-γ and tumor necrosis factor α. J. Exp. Med. 181:1615-1621.
9. Gately, M. K., A. G. Wolitzky, P. M. Quinn, and R. Chizzonite. 1992. Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell. Immunol. 143:127-142.
10. Gessani, S., P. Puddu, B. Varano, P. Borghi, L. Conti, L. Fantuzzi, and F. Belardelli. 1994. Induction of beta interferon by human immunodeficiency virus type 1 and its gp120 protein in human monocytes/macrophages: role of beta interferon in restriction of virus replication. J. Virol. 68:1983-1986.
11. Gessani, S., U. Testa, B. Varano, P. Di Marzio, P. Borghi, L. Conti, T. Barberi, E. Tritarelli, R. Martucci, D. Seripa, C. Peschle, and F. Belardelli. 1993. Enhanced production of LPS-induced cytokines during differentiation of human monocytes to macrophages. Role of LPS receptors. J. Immunol. 151:1-9.
12. Hayes, M. P., J. H. Wang, and M. A. Norcross. 1995. Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-γ of lipopolysaccharide-inducible p35 and p40 genes. Blood 86:646-650.
13. Jacobsen, H., J. Mestan, S. Mittnacht, and C. W. Dieffenbach. 1989. β-Interferon subtype 1 induction by tumor necrosis factor. Mol. Cell. Biol. 9:3037-3042.
14. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF) cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827-845.
15. Kubin, M., J. M. Chow, and G. Trinchieri. 1994. Differential regulation of interleukin-12 (1L-12), tumor necrosis factor α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood 83:1847-1855.
16. Levy, J. A. 1993. Pathogenesis of human immunodeficiency virus infection. Microbiol. Rev. 57:183-289.
17. Meltzer, M. S., M. Nakamura, B. D. Hansen, J. A. Turpin, D. C. Kalter, and H. E. Gendelman. 1990. Macrophages as susceptible targets for HIV-infection, persistent viral reservoirs in tissue and key immunoregulatory cells that control levels of virus replication and extent of disease. AIDS Res. Hum. Retroviruses 6:967-971.
18. Murray, H. W., B. V. Rubin, H. Masur, and R. B. Roberts. 1984. Impaired production of lymphokines and immune (gamma) interferon in the acquired immunodeficiency syndrome. N. Engl. J. Med. 310:883-889.
19. Schmitt, E., P. Hoehn, C. Huels, S. Goedert, N. Palm, E. Rude, and T. Germann. 1994. T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor-β. Eur. J. Immunol. 24:793-798.
20. H1 cells. Immunol. Today 14:335-337.
21. Wolf, S. F., D. Sieburth, and J. Sypek. 1994. Interleukin 12: a key modulator of immune function: Stem Cells 12:154-168.