Interferon-γ differentially regulates interleukin-12 and interleukin- 10 production in leprosy

Journal of Clinical Investigation

Volumn 99, Issue 2, 1997, Pages 336-341

  Libraty, Daniel H ^a   Airan, Lisa E ^a   Uyemura, Koichi ^a   Jullien, Denis ^a   Spellberg, Brad ^a   Rea, Thomas H ^b   Modlin, Robert L ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cytokine; immunity; infection; monocytes; mycobacteria

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; NEUTRALIZING ANTIBODY; RECOMBINANT INTERLEUKIN 10; RECOMBINANT INTERLEUKIN 12;

ARTICLE; CELL INTERACTION; CELL PROLIFERATION; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HELPER CELL; HUMAN; IMMUNE RESPONSE; LEPROMATOUS LEPROSY; MYCOBACTERIUM LEPRAE; NATURAL KILLER CELL; PRIORITY JOURNAL; STATISTICAL ANALYSIS; TUBERCULOID LEPROSY;

EID: 0031020203     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119162     Document Type: Article

References (33)

1. Heinzel, F.P., M.D. Sadick, B.J. Holaday, R.L. Coffman, and R.M. Locksley. 1989. Reciprocal expression of interferon gamma or inlerleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59.
2. Yamamura, M., K. Uyemura, R.J. Deans, K. Weinberg, T.H. Rea, B.R. Bloom, and R.L. Modlin. 1991. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science (Wash. DC). 254:277-279.
3. Salgame, P., J.S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R.L. Modlin, and B.R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science (Wash. DC). 254:279-282.
4. D'Andrea, A., M. Rengaraju, N.M. Valiante, J. Chehimi, M. Kubin, M. Aste, S.H. Chan, M. Kobayashi, D. Young, E. Nickbarg, et al. 1992. Production of natural killer cell stimulatory cell factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387-1398.
5. Hsieh, C., S.E. Macatonia, C.S. Tripp, S.F. Wolf, A. O'Garra, and K.M. Murphy. 1993. Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science (Wash. DC). 260:547-549.
6. Gazzinelli, R.T., M. Wysocka, S. Hayashi, E.Y. Deukers, S. Hieny, P. Caspar, G. Trinchieri, and A. Sher. 1994. Parasite induced IL-12 stimulates early IFN-gamma synthesis and resistance during infection with Toxoplasma gondii. J. Immunol. 153:2533-2543.
7. Heinzel, P.P., D.S. Schoenhaut, R.M. Rerko, L.E. Rosser, and M.K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505-1509.
8. Fiorentino, D.F., M.W. Bond, and T.R. Mosmann. 1989. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp. Med. 170:2081-2095.
9. de Waal Malefyt, R., J. Abrams, B. Bennett, C.G. Figdor, and J.E. De Vries. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1209-1220.
10. Ridley, D.S., and W.H. Jopling. 1966. Classification of leprosy according to immunity. A five-group system. Int. J. Lepr. 34:255-273.
11. Sieling, P.A., X.-H. Wang, M.K. Gately, J.L. Oliveros, T. McHugh, P.F. Barnes, S.F. Wolf, L. Golkar, M. Yamamura, Y. Yogi, et al. 1994. IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J. Immunol. 153:3639-3647.
12. Chomarat, P., M.C. Rissoan, J. Banchereau, and P. Miossec. 1993. Interferon gamma inhibits interleukin 10 production by monocytes. J. Exp. Med. 177:523-527.
13. Donnelly, R.P., S.L. Freeman, and M.P. Hayes. 1995. Inhibition of IL-10 expression by IFN-γ up-regulates transcription of TNF-a in human monocytes. J. Immunol. 155:1420-1427.
14. Roach, T.I.A., C.H. Barton, D. Chatterjee, F.Y. Liew, and J.M. Black-well. 1995. Opposing effects of interferon-gamma on iNOS and interleukin-10 expression in lipopolysaccharide- and mycobacterial lipoarabinomannan-stimulated macrophages. Immunology. 85:106-113.
15. Skeen, M.J., M.A. Miller, T.M. Shinnick, and H.K. Ziegler. 1996. Regulation of murine macrophage IL-12 production: activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. J. Immunol. 156:1196-1206.
16. Kubin, M., J.M. Chow, and G. Trinchieri. 1994. Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-I beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood. 83:1847-1855.
17. Sieling, P.A., J.S. Abrams, M. Yamamura, P. Salgame, B.R. Bloom, T.H. Rea, and R.L. Modlin. 1993. Immunosuppressive roles for interleukin-10 and interleukin-4 in human infection: in vitro modulation of T cell responses in leprosy. J. Immunol 150:5501-5510.
18. Nathan, C.F., G. Kaplan, W.R. Levis, A. Nusrat, M.D. Witmer, S.A. Sherwin, C.K. Job, C.R. Horowitz, R.M. Steinman, and Z.A. Cohn. 1986. Local and systemic effects of intradermal recombinant interferon-gamma in patients with lepromatous leprosy. N. Engl. J. Med. 315:6-15.
19. Murphy, T.L., M.G. Cleveland, P. Kulesza, J. Magram, and K.M. Murphy. 1995. Regulation of interleukin 12 p40 expression through an NF-kappa B half-site. Mol Cell Biol. 15:5258-5267.
20. Ma, X., J.M. Chow, G. Gri, G. Carra, F. Gerosa, S.F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J. Exp. Med. 183:147-157.
21. Marshall, J.D., H. Secrist, R.H. DeKruyff, S.F. Wolf, and D.T. Umetsu. 1995. IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes. J. Immunol. 155:111-117.
22. Meyaard, L., E. Hovenkamp, S.A. Otto, and F. Miedema. 1996. IL-12-induced IL-10 production by human T Cells as a negative feedback for IL-12-induced immune responses. J. Immunol. 156:2776-2782.
23. Jeannin, P., Y. Delneste, M. Seveso, P. Life, and J.Y. Bonnefoy. 1996. IL-12 synergizes with IL-2 and other stimuli in inducing IL-IO production by human T Cells. J. Immunol 156:3159-3165.
24. Flesch, I.E.A., J.H. Hess, S. Huang, M. Aguet, J. Rothe, H. Bluethmann, and S.H.E. Kaufmann. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor α. J. Exp. Med. 181:1615-1621.
25. Modlin, R.L., F.M. Hofman, C.R. Taylor, and T.H. Rea. 1983. T lymphocyte subsets in the skin lesions of patients with leprosy. J. Am. Acad. Dermatol. 8:182-189.
26. Modlin, R.L., C. Pirmez, F.M. Hofman, V. Torigian, K. Uyemura, T.H. Rea, B.R. Bloom, and M.B. Brenner. 1989. Lymphocytes bearing antigen-specific gamma/delta T-cell receptors in human infectious disease lesions. Nature (Land.). 339:544-548.
27. Tanaka, Y., C.T. Morita, E. Nieves, M.B. Brenner, and B.R. Bloom. 1995. Natural and synthetic nonpeptide antigens recognized by human gamma/ delta T cells. Nature (Land.). 375:155-158.
28. Constant, P., F. Davodeau, M. Peyrat, Y. Poquet, G. Puzo, M. Bonneville, and J. Fournie. 1994. Stimulation of human gamma delta T cells by non-peptidic mycobacterial ligands. Science (Wash. DC). 264:267-270.
29. Barnes, P.F., C.L. Grisso, J.S. Abrams, H. Band, T.H. Rea, and R.L. Modlin. 1992. Gamma/delta T-lymphocytes in human tuberculosis. J. Infect. Dis. 165:506-512.
30. Chehimi, J., S.E. Starr, I. Frank, A. D'Andrea, X. Ma, R.R. MacGregor, J. Sennelier, and G. Trinchieri. 1994. Impaired IL-12 production in human immunodeficiency virus-infected patients. J. Exp. Med. 179:1361-1366.
31. Chougnet, C., M. Clerici, and G.M. Shearer. 1995. Roles of IL12 in HIV disease/AIDS. Res. Immunol 146:615-619.
32. Clerici, M., T.A. Wynn, J.A. Berzofsky, S.P. Blatt, C.W. Hendrix, A. Sher, R.L. Coffman, and G.M. Shearer. 1994. Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J. Clin. Invest. 93:768-775.
33. Ghalib, H.W., J.A. Whittle, M. Kubin, F.A. Hashim, A.M. EI-Hassan, K.H. Grabstein, G. Trinchieri, and S.G. Reed. 1995. IL-12 enhances Thl-type responses in human Leishmunia donovani infections. J. Immunol 154:4623-4629.