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Volumn 11, Issue 1, 2018, Pages

Lessons learned from the blockade of immune checkpoints in cancer immunotherapy Ahmed Tarhini; Timothy Burns; Rahul Parikh; Guarvel Goel; Annie im

Author keywords

Cancer immunotherapy; Combination immunotherapy; Immune checkpoint blockade; Resistance mechanism; Tumor microenvironment

Indexed keywords

IMMUNOLOGICAL ANTINEOPLASTIC AGENT;

EID: 85042599208     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-018-0578-4     Document Type: Review
Times cited : (270)

References (241)
  • 1
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • 1:CAS:528:DC%2BD1MXhsFeqsbw%3D 19197294 2828349
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9(3):162-74.
    • (2009) Nat Rev Immunol , vol.9 , Issue.3 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 2
    • 84941655113 scopus 로고    scopus 로고
    • Cancer immunotherapy: Harnessing the immune system to battle cancer
    • 26325031 4588312
    • Yang Y. Cancer immunotherapy: harnessing the immune system to battle cancer. J Clin Invest. 2015;125(9):3335-7.
    • (2015) J Clin Invest , vol.125 , Issue.9 , pp. 3335-3337
    • Yang, Y.1
  • 3
    • 85016510938 scopus 로고    scopus 로고
    • Harnessing the immunotherapy revolution for the treatment of childhood cancers
    • 1:CAS:528:DC%2BC2sXlsVCisrw%3D 28366678
    • Majzner RG, Heitzeneder S, Mackall CL. Harnessing the immunotherapy revolution for the treatment of childhood cancers. Cancer Cell. 2017;31(4):476-85.
    • (2017) Cancer Cell , vol.31 , Issue.4 , pp. 476-485
    • Majzner, R.G.1    Heitzeneder, S.2    Mackall, C.L.3
  • 4
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • 1:CAS:528:DC%2BC38XksVegtrw%3D 22437870 4856023
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12(4):252-64.
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 5
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • 1:CAS:528:DC%2BC2MXls1Wmurg%3D 25838373
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science. 2015;348(6230):56-61.
    • (2015) Science , vol.348 , Issue.6230 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 6
    • 85035343267 scopus 로고    scopus 로고
    • De-novo and acquired resistance to immune checkpoint targeting
    • 29208439
    • Syn NL, Teng MWL, Mok TSK, Soo RA. De-novo and acquired resistance to immune checkpoint targeting. Lancet Oncol. 2017;18(12):e731-41.
    • (2017) Lancet Oncol , vol.18 , Issue.12 , pp. e731-e741
    • Syn, N.L.1    Teng, M.W.L.2    Mok, T.S.K.3    Soo, R.A.4
  • 7
    • 85004140713 scopus 로고    scopus 로고
    • Emerging therapeutic agents for lung cancer
    • 27938382 5148871 1:CAS:528:DC%2BC1cXhsVylsbg%3D
    • Dholaria B, Hammond W, Shreders A, Lou Y. Emerging therapeutic agents for lung cancer. J Hematol Oncol. 2016;9(1):138.
    • (2016) J Hematol Oncol , vol.9 , Issue.1 , pp. 138
    • Dholaria, B.1    Hammond, W.2    Shreders, A.3    Lou, Y.4
  • 8
    • 0014941813 scopus 로고
    • A theory of self-nonself discrimination
    • 1:CAS:528:DyaE3MXit1Gl 4194660
    • Bretscher P, Cohn M. A theory of self-nonself discrimination. Science. 1970;169(3950):1042-9.
    • (1970) Science , vol.169 , Issue.3950 , pp. 1042-1049
    • Bretscher, P.1    Cohn, M.2
  • 9
    • 0017603174 scopus 로고
    • A simple conservative explanation of the H-2 restriction of interactions between lymphocytes
    • 1:STN:280:DyaE2s7ltVGgtg%3D%3D 300494
    • Cunningham AJ, Lafferty KJ. A simple conservative explanation of the H-2 restriction of interactions between lymphocytes. Scand J Immunol. 1977;6(1-2):1-6.
    • (1977) Scand J Immunol , vol.6 , Issue.1-2 , pp. 1-6
    • Cunningham, A.J.1    Lafferty, K.J.2
  • 10
    • 0016705018 scopus 로고
    • A new analysis of allogeneic interactions
    • 1:STN:280:DyaE2M3gsVKntg%3D%3D 238498
    • Lafferty KJ, Cunningham AJ. A new analysis of allogeneic interactions. Aust J Exp Biol Med Sci. 1975;53(1):27-42.
    • (1975) Aust J Exp Biol Med Sci , vol.53 , Issue.1 , pp. 27-42
    • Lafferty, K.J.1    Cunningham, A.J.2
  • 11
    • 84966738229 scopus 로고    scopus 로고
    • Coinhibitory pathways in the B7-CD28 ligand-receptor family
    • 1:CAS:528:DC%2BC28XotFars7o%3D 27192563 4905708
    • Schildberg FA, Klein SR, Freeman GJ, Sharpe AH. Coinhibitory pathways in the B7-CD28 ligand-receptor family. Immunity. 2016;44(5):955-72.
    • (2016) Immunity , vol.44 , Issue.5 , pp. 955-972
    • Schildberg, F.A.1    Klein, S.R.2    Freeman, G.J.3    Sharpe, A.H.4
  • 12
    • 84906846048 scopus 로고    scopus 로고
    • Emerging co-signaling networks in T cell immune regulation
    • 24198743 3817299
    • Jung K, Choi I. Emerging co-signaling networks in T cell immune regulation. Immune Netw. 2013;13(5):184-93.
    • (2013) Immune Netw , vol.13 , Issue.5 , pp. 184-193
    • Jung, K.1    Choi, I.2
  • 14
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • 1:CAS:528:DC%2BD1MXps1enu7w%3D 19581407 2722174
    • Peggs KS, Quezada SA, Chambers CA, Korman AJ, Allison JP. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med. 2009;206(8):1717-25.
    • (2009) J Exp Med , vol.206 , Issue.8 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 16
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and co-inhibition
    • 23470321 3786574 1:CAS:528:DC%2BC3sXjsFCgtLc%3D
    • Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol. 2013;13(4):227-42.
    • (2013) Nat Rev Immunol , vol.13 , Issue.4 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 17
    • 84959529731 scopus 로고    scopus 로고
    • PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations
    • 1:CAS:528:DC%2BC2sXltFemsQ%3D%3D
    • Zou W, Wolchok JD, Chen L. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations. Sci Transl Med. 2016;8(328):328rv324.
    • (2016) Sci Transl Med , vol.8 , Issue.328 , pp. 328rv324
    • Zou, W.1    Wolchok, J.D.2    Chen, L.3
  • 18
    • 84926528302 scopus 로고    scopus 로고
    • Overcoming T cell exhaustion in infection and cancer
    • 1:CAS:528:DC%2BC2MXjvFCjsLo%3D 25797516 4393798
    • Pauken KE, Wherry EJ. Overcoming T cell exhaustion in infection and cancer. Trends Immunol. 2015;36(4):265-76.
    • (2015) Trends Immunol , vol.36 , Issue.4 , pp. 265-276
    • Pauken, K.E.1    Wherry, E.J.2
  • 19
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • 1:CAS:528:DC%2BD1MXhs1WlsbrP 20008522 2806460
    • Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 2009;206(13):3015-29.
    • (2009) J Exp Med , vol.206 , Issue.13 , pp. 3015-3029
    • Francisco, L.M.1    Salinas, V.H.2    Brown, K.E.3    Vanguri, V.K.4    Freeman, G.J.5    Kuchroo, V.K.6    Sharpe, A.H.7
  • 22
    • 85036569976 scopus 로고    scopus 로고
    • Recent development in clinical applications of PD-1 and PD-L1 antibodies for cancer immunotherapy
    • 29195503 5712158
    • Liu B, Song Y, Liu D. Recent development in clinical applications of PD-1 and PD-L1 antibodies for cancer immunotherapy. J Hematol Oncol. 2017;10(1):174.
    • (2017) J Hematol Oncol , vol.10 , Issue.1 , pp. 174
    • Liu, B.1    Song, Y.2    Liu, D.3
  • 23
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: Toward combination strategies with curative potential
    • 1:CAS:528:DC%2BC2MXmsVWqsbc%3D 25860605
    • Sharma P, Allison JP. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell. 2015;161(2):205-14.
    • (2015) Cell , vol.161 , Issue.2 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 32
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
    • 1:CAS:528:DC%2BC3MXjs1Cgtbs%3D 21436444
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science. 2011;331(6024):1565-70.
    • (2011) Science , vol.331 , Issue.6024 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 33
    • 33748987908 scopus 로고    scopus 로고
    • Cancer despite immunosurveillance: Immunoselection and immunosubversion
    • 1:CAS:528:DC%2BD28XhtVSgurnM 16977338
    • Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol. 2006;6(10):715-27.
    • (2006) Nat Rev Immunol , vol.6 , Issue.10 , pp. 715-727
    • Zitvogel, L.1    Tesniere, A.2    Kroemer, G.3
  • 34
    • 0036852241 scopus 로고    scopus 로고
    • Cancer immunoediting: From immunosurveillance to tumor escape
    • 1:CAS:528:DC%2BD38Xot1Chs70%3D 12407406
    • Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol. 2002;3(11):991-8.
    • (2002) Nat Immunol , vol.3 , Issue.11 , pp. 991-998
    • Dunn, G.P.1    Bruce, A.T.2    Ikeda, H.3    Old, L.J.4    Schreiber, R.D.5
  • 35
    • 85019445283 scopus 로고    scopus 로고
    • Utility of PD-L1 immunohistochemistry assays for predicting PD-1/PD-L1 inhibitor response
    • 28331612 5353958
    • Diggs LP, Hsueh EC. Utility of PD-L1 immunohistochemistry assays for predicting PD-1/PD-L1 inhibitor response. Biomark Res. 2017;5:12.
    • (2017) Biomark Res , vol.5 , pp. 12
    • Diggs, L.P.1    Hsueh, E.C.2
  • 36
    • 84962431681 scopus 로고    scopus 로고
    • Case report: Mismatch repair proficiency and microsatellite stability in gastric cancer may not predict programmed death-1 blockade resistance
    • 27012666 4806434
    • Chen KH, Yuan CT, Tseng LH, Shun CT, Yeh KH. Case report: mismatch repair proficiency and microsatellite stability in gastric cancer may not predict programmed death-1 blockade resistance. J Hematol Oncol. 2016;9:29.
    • (2016) J Hematol Oncol , vol.9 , pp. 29
    • Chen, K.H.1    Yuan, C.T.2    Tseng, L.H.3    Shun, C.T.4    Yeh, K.H.5
  • 37
    • 84971280558 scopus 로고    scopus 로고
    • Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy
    • 27234522 4884396 1:CAS:528:DC%2BC2sXnsVChsb0%3D
    • Ma W, Gilligan BM, Yuan J, Li T. Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy. J Hematol Oncol. 2016;9(1):47.
    • (2016) J Hematol Oncol , vol.9 , Issue.1 , pp. 47
    • Ma, W.1    Gilligan, B.M.2    Yuan, J.3    Li, T.4
  • 38
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • 1:CAS:528:DC%2BC38Xkt1ykt7w%3D 22439926
    • Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012;21(3):309-22.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 39
    • 85016548232 scopus 로고    scopus 로고
    • Elements of cancer immunity and the cancer-immune set point
    • 1:CAS:528:DC%2BC2sXht1Oksr8%3D 28102259
    • Chen DS, Mellman I. Elements of cancer immunity and the cancer-immune set point. Nature. 2017;541(7637):321-30.
    • (2017) Nature , vol.541 , Issue.7637 , pp. 321-330
    • Chen, D.S.1    Mellman, I.2
  • 40
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: The cancer-immunity cycle
    • 23890059 1:CAS:528:DC%2BC3sXhtFOhs7vL
    • Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39(1):1-10.
    • (2013) Immunity , vol.39 , Issue.1 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 41
    • 84928771999 scopus 로고    scopus 로고
    • T cell exclusion, immune privilege, and the tumor microenvironment
    • 1:CAS:528:DC%2BC2MXls1Wmu74%3D 25838376
    • Joyce JA, Fearon DT. T cell exclusion, immune privilege, and the tumor microenvironment. Science. 2015;348(6230):74-80.
    • (2015) Science , vol.348 , Issue.6230 , pp. 74-80
    • Joyce, J.A.1    Fearon, D.T.2
  • 42
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • 1:CAS:528:DC%2BD38XntlCksL8%3D 12218188 129438
    • Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 2002;99(19):12293-7.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.19 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 46
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • 1:CAS:528:DC%2BC38XhsVaksLjK
    • Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, Chen S, Klein AP, Pardoll DM, Topalian SL, Chen L. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med. 2012;4(127):127ra137.
    • (2012) Sci Transl Med , vol.4 , Issue.127 , pp. 127ra137
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3    Xu, H.4    Sharma, R.5    McMiller, T.L.6    Chen, S.7    Klein, A.P.8    Pardoll, D.M.9    Topalian, S.L.10    Chen, L.11
  • 47
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells
    • 23986400 4136707 1:CAS:528:DC%2BC3sXhsFSqt77L
    • Spranger S, Spaapen RM, Zha Y, Williams J, Meng Y, Ha TT, Gajewski TF. Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. Sci Transl Med. 2013;5(200):200ra116.
    • (2013) Sci Transl Med , vol.5 , Issue.200 , pp. 200ra116
    • Spranger, S.1    Spaapen, R.M.2    Zha, Y.3    Williams, J.4    Meng, Y.5    Ha, T.T.6    Gajewski, T.F.7
  • 50
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    • 1:CAS:528:DC%2BD2MXjt1Ohsbk%3D 15780990
    • Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 2005;22(3):329-41.
    • (2005) Immunity , vol.22 , Issue.3 , pp. 329-341
    • Fontenot, J.D.1    Rasmussen, J.P.2    Williams, L.M.3    Dooley, J.L.4    Farr, A.G.5    Rudensky, A.Y.6
  • 51
    • 84874608992 scopus 로고    scopus 로고
    • Control of inflammation by integration of environmental cues by regulatory T cells
    • 1:CAS:528:DC%2BC3sXjvVyhs7c%3D 23454755 3582113
    • Chaudhry A, Rudensky AY. Control of inflammation by integration of environmental cues by regulatory T cells. J Clin Invest. 2013;123(3):939-44.
    • (2013) J Clin Invest , vol.123 , Issue.3 , pp. 939-944
    • Chaudhry, A.1    Rudensky, A.Y.2
  • 52
    • 84860507700 scopus 로고    scopus 로고
    • T-regulatory cells: Key players in tumor immune escape and angiogenesis
    • 1:CAS:528:DC%2BC38Xmt1yms7c%3D 22549946 3342842
    • Facciabene A, Motz GT, Coukos G. T-regulatory cells: key players in tumor immune escape and angiogenesis. Cancer Res. 2012;72(9):2162-71.
    • (2012) Cancer Res , vol.72 , Issue.9 , pp. 2162-2171
    • Facciabene, A.1    Motz, G.T.2    Coukos, G.3
  • 54
    • 84855338629 scopus 로고    scopus 로고
    • Regulatory T cells in melanoma: The final hurdle towards effective immunotherapy?
    • 1:CAS:528:DC%2BC38XkslSluw%3D%3D 22225723
    • Jacobs JF, Nierkens S, Figdor CG, de Vries IJ, Adema GJ. Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy? Lancet Oncol. 2012;13(1):e32-42.
    • (2012) Lancet Oncol , vol.13 , Issue.1 , pp. e32-e42
    • Jacobs, J.F.1    Nierkens, S.2    Figdor, C.G.3    De Vries, I.J.4    Adema, G.J.5
  • 56
    • 68249152608 scopus 로고    scopus 로고
    • Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo
    • 1:CAS:528:DC%2BD1MXpsFOgu7w%3D 19604493 3039716
    • Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity. 2009;31(1):145-57.
    • (2009) Immunity , vol.31 , Issue.1 , pp. 145-157
    • Tinoco, R.1    Alcalde, V.2    Yang, Y.3    Sauer, K.4    Zuniga, E.I.5
  • 57
    • 58149484842 scopus 로고    scopus 로고
    • IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection
    • 1:CAS:528:DC%2BD1MXhtleitA%3D%3D 19075244 2629263
    • Brooks DG, Ha SJ, Elsaesser H, Sharpe AH, Freeman GJ, Oldstone MB. IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection. Proc Natl Acad Sci U S A. 2008;105(51):20428-33.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.51 , pp. 20428-20433
    • Brooks, D.G.1    Ha, S.J.2    Elsaesser, H.3    Sharpe, A.H.4    Freeman, G.J.5    Oldstone, M.B.6
  • 58
  • 60
    • 77949425341 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance to tumors
    • 19763889
    • Cao X. Regulatory T cells and immune tolerance to tumors. Immunol Res. 2010;46(1-3):79-93.
    • (2010) Immunol Res , vol.46 , Issue.1-3 , pp. 79-93
    • Cao, X.1
  • 62
    • 85006789449 scopus 로고    scopus 로고
    • Regulatory T cells in cancer immunotherapy
    • 1:CAS:528:DC%2BC28XitFCmtr7M 27995907
    • Tanaka A, Sakaguchi S. Regulatory T cells in cancer immunotherapy. Cell Res. 2017;27(1):109-18.
    • (2017) Cell Res , vol.27 , Issue.1 , pp. 109-118
    • Tanaka, A.1    Sakaguchi, S.2
  • 65
    • 33745851479 scopus 로고    scopus 로고
    • CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
    • 1:CAS:528:DC%2BD28XmvV2lurw%3D 16778987 1479425
    • Quezada SA, Peggs KS, Curran MA, Allison JP. CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J Clin Invest. 2006;116(7):1935-45.
    • (2006) J Clin Invest , vol.116 , Issue.7 , pp. 1935-1945
    • Quezada, S.A.1    Peggs, K.S.2    Curran, M.A.3    Allison, J.P.4
  • 69
    • 0032533478 scopus 로고    scopus 로고
    • Apoptotic death of CD8+ T lymphocytes after immunization: Induction of a suppressive population of mac-1+/gr-1+ cells
    • 1:CAS:528:DyaK1cXnsVOrtb0%3D 9820504 2239007
    • Bronte V, Wang M, Overwijk WW, Surman DR, Pericle F, Rosenberg SA, Restifo NP. Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of mac-1+/gr-1+ cells. J Immunol. 1998;161(10):5313-20.
    • (1998) J Immunol , vol.161 , Issue.10 , pp. 5313-5320
    • Bronte, V.1    Wang, M.2    Overwijk, W.W.3    Surman, D.R.4    Pericle, F.5    Rosenberg, S.A.6    Restifo, N.P.7
  • 70
    • 84884556145 scopus 로고    scopus 로고
    • History of myeloid-derived suppressor cells
    • 1:CAS:528:DC%2BC3sXhsV2jsbfL 24060865 4358792
    • Talmadge JE, Gabrilovich DI. History of myeloid-derived suppressor cells. Nat Rev Cancer. 2013;13(10):739-52.
    • (2013) Nat Rev Cancer , vol.13 , Issue.10 , pp. 739-752
    • Talmadge, J.E.1    Gabrilovich, D.I.2
  • 71
    • 5444225991 scopus 로고    scopus 로고
    • Expansion of myeloid immune suppressor gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    • 1:CAS:528:DC%2BD2cXpsF2rtLo%3D 15488763
    • Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, Matrisian LM, Carbone DP, Lin PC. Expansion of myeloid immune suppressor gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell. 2004;6(4):409-21.
    • (2004) Cancer Cell , vol.6 , Issue.4 , pp. 409-421
    • Yang, L.1    DeBusk, L.M.2    Fukuda, K.3    Fingleton, B.4    Green-Jarvis, B.5    Shyr, Y.6    Matrisian, L.M.7    Carbone, D.P.8    Lin, P.C.9
  • 75
    • 84869791457 scopus 로고    scopus 로고
    • Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma
    • 1:CAS:528:DC%2BC38Xhs12gt73J 23100512 3505990
    • Kodumudi KN, Weber A, Sarnaik AA, Pilon-Thomas S. Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma. J Immunol. 2012;189(11):5147-54.
    • (2012) J Immunol , vol.189 , Issue.11 , pp. 5147-5154
    • Kodumudi, K.N.1    Weber, A.2    Sarnaik, A.A.3    Pilon-Thomas, S.4
  • 76
    • 84900839768 scopus 로고    scopus 로고
    • Cancer vaccines in the world of immune suppressive monocytes (CD14(+)HLA-DR(lo/neg) cells): The gateway to improved responses
    • 24772111 3983500 1:CAS:528:DC%2BC2MXht1enurnL
    • Laborde RR, Lin Y, Gustafson MP, Bulur PA, Dietz AB. Cancer vaccines in the world of immune suppressive monocytes (CD14(+)HLA-DR(lo/neg) cells): the gateway to improved responses. Front Immunol. 2014;5:147.
    • (2014) Front Immunol , vol.5 , pp. 147
    • Laborde, R.R.1    Lin, Y.2    Gustafson, M.P.3    Bulur, P.A.4    Dietz, A.B.5
  • 79
    • 85016111488 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells
    • 1:CAS:528:DC%2BC2sXhs1Wltw%3D%3D 28052991 5426480
    • Gabrilovich DI. Myeloid-derived suppressor cells. Cancer Immunol Res. 2017;5(1):3-8.
    • (2017) Cancer Immunol Res , vol.5 , Issue.1 , pp. 3-8
    • Gabrilovich, D.I.1
  • 82
    • 34548686289 scopus 로고    scopus 로고
    • Apoptosis signaling pathways and lymphocyte homeostasis
    • 1:CAS:528:DC%2BD2sXhtVeis77M 17576411
    • Xu G, Shi Y. Apoptosis signaling pathways and lymphocyte homeostasis. Cell Res. 2007;17(9):759-71.
    • (2007) Cell Res , vol.17 , Issue.9 , pp. 759-771
    • Xu, G.1    Shi, Y.2
  • 84
    • 84916208655 scopus 로고    scopus 로고
    • Adams EJ: γδ T cell surveillance via CD1 molecules
    • 1:CAS:528:DC%2BC2cXhs1ShtrvJ 25283967 4383740
    • Luoma AM, Castro CD. Adams EJ: γδ T cell surveillance via CD1 molecules. Trends Immunol. 2014;35(12):613-21.
    • (2014) Trends Immunol , vol.35 , Issue.12 , pp. 613-621
    • Luoma, A.M.1    Castro, C.D.2
  • 85
    • 84886944509 scopus 로고    scopus 로고
    • Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity
    • 23802074 3661159
    • Kabelitz D, Kalyan S, Oberg HH, Wesch D. Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity. Oncoimmunology. 2013;2(3):e23304.
    • (2013) Oncoimmunology , vol.2 , Issue.3 , pp. e23304
    • Kabelitz, D.1    Kalyan, S.2    Oberg, H.H.3    Wesch, D.4
  • 86
    • 85024091630 scopus 로고    scopus 로고
    • Yan J: γδ T cells: Unexpected regulators of cancer development and progression
    • 28780933
    • Fleming C, Morrissey S, Cai Y. Yan J: γδ T cells: unexpected regulators of cancer development and progression. Trends Cancer. 2017;3(8):561-70.
    • (2017) Trends Cancer , vol.3 , Issue.8 , pp. 561-570
    • Fleming, C.1    Morrissey, S.2    Cai, Y.3
  • 91
    • 84994144900 scopus 로고    scopus 로고
    • Tumour-associated mesenchymal stem/stromal cells: Emerging therapeutic targets
    • 1:CAS:528:DC%2BC28XhslynsLrE 27811929
    • Shi Y, Du L, Lin L, Wang Y. Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets. Nat Rev Drug Discov. 2017;16(1):35-52.
    • (2017) Nat Rev Drug Discov , vol.16 , Issue.1 , pp. 35-52
    • Shi, Y.1    Du, L.2    Lin, L.3    Wang, Y.4
  • 92
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    • 1:CAS:528:DC%2BD1MXhtlyjs7vL 19741157
    • Solinas G, Germano G, Mantovani A, Allavena P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol. 2009;86(5):1065-73.
    • (2009) J Leukoc Biol , vol.86 , Issue.5 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3    Allavena, P.4
  • 93
    • 84910040336 scopus 로고    scopus 로고
    • Molecular pathways: Myeloid complicity in cancer
    • 1:CAS:528:DC%2BC2cXhslKgu7fM 25047706 4269607
    • Stromnes IM, Greenberg PD, Hingorani SR. Molecular pathways: myeloid complicity in cancer. Clin Cancer Res. 2014;20(20):5157-70.
    • (2014) Clin Cancer Res , vol.20 , Issue.20 , pp. 5157-5170
    • Stromnes, I.M.1    Greenberg, P.D.2    Hingorani, S.R.3
  • 94
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
    • 1:CAS:528:DC%2BC3cXhtFyhtrrL 20856220
    • Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol. 2010;11(10):889-96.
    • (2010) Nat Immunol , vol.11 , Issue.10 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 95
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • 1:CAS:528:DC%2BD38XotVKktrc%3D 12401408
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002;23(11):549-55.
    • (2002) Trends Immunol , vol.23 , Issue.11 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 96
    • 84875253893 scopus 로고    scopus 로고
    • Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer
    • 1:CAS:528:DC%2BC3sXit1ylurk%3D 23348699
    • Tang X. Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer. Cancer Lett. 2013;332(1):3-10.
    • (2013) Cancer Lett , vol.332 , Issue.1 , pp. 3-10
    • Tang, X.1
  • 97
    • 67449110979 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    • 1:CAS:528:DC%2BD1MXntFGmu7k%3D 19451266 2715058
    • Kuang DM, Zhao Q, Peng C, Xu J, Zhang JP, Wu C, Zheng L. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med. 2009;206(6):1327-37.
    • (2009) J Exp Med , vol.206 , Issue.6 , pp. 1327-1337
    • Kuang, D.M.1    Zhao, Q.2    Peng, C.3    Xu, J.4    Zhang, J.P.5    Wu, C.6    Zheng, L.7
  • 101
    • 84907484156 scopus 로고    scopus 로고
    • CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models
    • 1:CAS:528:DC%2BC2cXhsFChtbjO 25082815 4182950
    • Zhu Y, Knolhoff BL, Meyer MA, Nywening TM, West BL, Luo J, Wang-Gillam A, Goedegebuure SP, Linehan DC, DeNardo DG. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res. 2014;74(18):5057-69.
    • (2014) Cancer Res , vol.74 , Issue.18 , pp. 5057-5069
    • Zhu, Y.1    Knolhoff, B.L.2    Meyer, M.A.3    Nywening, T.M.4    West, B.L.5    Luo, J.6    Wang-Gillam, A.7    Goedegebuure, S.P.8    Linehan, D.C.9    DeNardo, D.G.10
  • 102
    • 84936953099 scopus 로고    scopus 로고
    • Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
    • 1:CAS:528:DC%2BC2MXhtFaitrrL 25970248
    • Spranger S, Bao R, Gajewski TF. Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity. Nature. 2015;523(7559):231-5.
    • (2015) Nature , vol.523 , Issue.7559 , pp. 231-235
    • Spranger, S.1    Bao, R.2    Gajewski, T.F.3
  • 104
    • 84860217431 scopus 로고    scopus 로고
    • The functions and regulation of the PTEN tumour suppressor
    • 1:CAS:528:DC%2BC38XkvFSrurg%3D 22473468
    • Song MS, Salmena L, Pandolfi PP. The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol. 2012;13(5):283-96.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.5 , pp. 283-296
    • Song, M.S.1    Salmena, L.2    Pandolfi, P.P.3
  • 107
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • 1:CAS:528:DyaK2cXktlalsL4%3D 8197455
    • Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 1994;264(5164):1415-21.
    • (1994) Science , vol.264 , Issue.5164 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 108
    • 0030889207 scopus 로고    scopus 로고
    • The IFN gamma receptor: A paradigm for cytokine receptor signaling
    • 1:CAS:528:DyaK2sXisVCmt7c%3D 9143700
    • Bach EA, Aguet M, Schreiber RD. The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu Rev Immunol. 1997;15:563-91.
    • (1997) Annu Rev Immunol , vol.15 , pp. 563-591
    • Bach, E.A.1    Aguet, M.2    Schreiber, R.D.3
  • 110
    • 17144365840 scopus 로고    scopus 로고
    • IFN unresponsiveness in LNCaP cells due to the lack of JAK1 gene expression
    • 1:CAS:528:DC%2BD2MXjt1yrtr0%3D 15833880
    • Dunn GP, Sheehan KC, Old LJ, Schreiber RD. IFN unresponsiveness in LNCaP cells due to the lack of JAK1 gene expression. Cancer Res. 2005;65(8):3447-53.
    • (2005) Cancer Res , vol.65 , Issue.8 , pp. 3447-3453
    • Dunn, G.P.1    Sheehan, K.C.2    Old, L.J.3    Schreiber, R.D.4
  • 114
    • 84885670616 scopus 로고    scopus 로고
    • Fueling immunity: Insights into metabolism and lymphocyte function
    • 24115444 4486656 1:CAS:528:DC%2BC3sXhsFyns73L
    • Pearce EL, Poffenberger MC, Chang CH, Jones RG. Fueling immunity: insights into metabolism and lymphocyte function. Science. 2013;342(6155):1242454.
    • (2013) Science , vol.342 , Issue.6155 , pp. 1242454
    • Pearce, E.L.1    Poffenberger, M.C.2    Chang, C.H.3    Jones, R.G.4
  • 115
    • 85018769485 scopus 로고    scopus 로고
    • Metabolic instruction of immunity
    • 1:CAS:528:DC%2BC2sXnt1CmsLc%3D 28475890
    • Buck MD, Sowell RT, Kaech SM, Pearce EL. Metabolic instruction of immunity. Cell. 2017;169(4):570-86.
    • (2017) Cell , vol.169 , Issue.4 , pp. 570-586
    • Buck, M.D.1    Sowell, R.T.2    Kaech, S.M.3    Pearce, E.L.4
  • 116
    • 84947591002 scopus 로고    scopus 로고
    • T cell metabolism drives immunity
    • 1:CAS:528:DC%2BC2MXhsVyhsb7L 26261266 4548052
    • Buck MD, O'Sullivan D, Pearce EL. T cell metabolism drives immunity. J Exp Med. 2015;212(9):1345-60.
    • (2015) J Exp Med , vol.212 , Issue.9 , pp. 1345-1360
    • Buck, M.D.1    O'Sullivan, D.2    Pearce, E.L.3
  • 117
    • 84960399221 scopus 로고    scopus 로고
    • Immunometabolism governs dendritic cell and macrophage function
    • 26694970 4710204 1:CAS:528:DC%2BC28Xot1Whsro%3D
    • O'Neill LA, Pearce EJ. Immunometabolism governs dendritic cell and macrophage function. J Exp Med. 2016;213(1):15-23.
    • (2016) J Exp Med , vol.213 , Issue.1 , pp. 15-23
    • O'Neill, L.A.1    Pearce, E.J.2
  • 122
    • 85021169322 scopus 로고    scopus 로고
    • Glutaminolysis: A Hallmark of cancer metabolism
    • 1:CAS:528:DC%2BC2sXksVCqsLo%3D 28301735
    • Yang L, Venneti S, Nagrath D. Glutaminolysis: a Hallmark of cancer metabolism. Annu Rev Biomed Eng. 2017;19:163-94.
    • (2017) Annu Rev Biomed Eng , vol.19 , pp. 163-194
    • Yang, L.1    Venneti, S.2    Nagrath, D.3
  • 123
    • 84982993825 scopus 로고    scopus 로고
    • From Krebs to clinic: Glutamine metabolism to cancer therapy
    • 1:CAS:528:DC%2BC28Xht12jurbI 27492215 5484415
    • Altman BJ, Stine ZE, Dang CV. From Krebs to clinic: glutamine metabolism to cancer therapy. Nat Rev Cancer. 2016;16(10):619-34.
    • (2016) Nat Rev Cancer , vol.16 , Issue.10 , pp. 619-634
    • Altman, B.J.1    Stine, Z.E.2    Dang, C.V.3
  • 126
    • 84940890382 scopus 로고    scopus 로고
    • Big opportunities for small molecules in immuno-oncology
    • 1:CAS:528:DC%2BC2MXht1KiurvE 26228631
    • Adams JL, Smothers J, Srinivasan R, Hoos A. Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov. 2015;14(9):603-22.
    • (2015) Nat Rev Drug Discov , vol.14 , Issue.9 , pp. 603-622
    • Adams, J.L.1    Smothers, J.2    Srinivasan, R.3    Hoos, A.4
  • 128
    • 84937837169 scopus 로고    scopus 로고
    • Molecular and cellular insights into T cell exhaustion
    • 1:CAS:528:DC%2BC2MXht1ensLvE 26205583 4889009
    • Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 2015;15(8):486-99.
    • (2015) Nat Rev Immunol , vol.15 , Issue.8 , pp. 486-499
    • Wherry, E.J.1    Kurachi, M.2
  • 131
    • 84912111808 scopus 로고    scopus 로고
    • The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection
    • 1:CAS:528:DC%2BC2cXhvFart7%2FM 25464856 4270830
    • Staron MM, Gray SM, Marshall HD, Parish IA, Chen JH, Perry CJ, Cui G, Li MO, Kaech SM. The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection. Immunity. 2014;41(5):802-14.
    • (2014) Immunity , vol.41 , Issue.5 , pp. 802-814
    • Staron, M.M.1    Gray, S.M.2    Marshall, H.D.3    Parish, I.A.4    Chen, J.H.5    Perry, C.J.6    Cui, G.7    Li, M.O.8    Kaech, S.M.9
  • 134
    • 84938350452 scopus 로고    scopus 로고
    • Combination cancer immunotherapy and new immunomodulatory targets
    • 1:CAS:528:DC%2BC2MXht1KiurrJ 26228759
    • Mahoney KM, Rennert PD, Freeman GJ. Combination cancer immunotherapy and new immunomodulatory targets. Nat Rev Drug Discov. 2015;14(8):561-84.
    • (2015) Nat Rev Drug Discov , vol.14 , Issue.8 , pp. 561-584
    • Mahoney, K.M.1    Rennert, P.D.2    Freeman, G.J.3
  • 136
    • 85029354547 scopus 로고    scopus 로고
    • Monitoring immune-checkpoint blockade: Response evaluation and biomarker development
    • 1:CAS:528:DC%2BC2sXhtVOjtL3K 28653677
    • Nishino M, Ramaiya NH, Hatabu H, Hodi FS. Monitoring immune-checkpoint blockade: response evaluation and biomarker development. Nat Rev Clin Oncol. 2017;14(11):655-68.
    • (2017) Nat Rev Clin Oncol , vol.14 , Issue.11 , pp. 655-668
    • Nishino, M.1    Ramaiya, N.H.2    Hatabu, H.3    Hodi, F.S.4
  • 139
    • 84977161108 scopus 로고    scopus 로고
    • Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment
    • 24829760 4019906
    • Spranger S, Koblish HK, Horton B, Scherle PA, Newton R, Gajewski TF. Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment. J Immunother Cancer. 2014;2:3.
    • (2014) J Immunother Cancer , vol.2 , pp. 3
    • Spranger, S.1    Koblish, H.K.2    Horton, B.3    Scherle, P.A.4    Newton, R.5    Gajewski, T.F.6
  • 143
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: A common denominator approach to cancer therapy
    • 1:CAS:528:DC%2BC2MXmtVaku7k%3D 25858804 4400238
    • Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell. 2015;27(4):450-61.
    • (2015) Cancer Cell , vol.27 , Issue.4 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 146
    • 0035855872 scopus 로고    scopus 로고
    • Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
    • 1:CAS:528:DC%2BD3MXntVOqtrk%3D 11557981 3900321
    • Diefenbach A, Jensen ER, Jamieson AM, Raulet DH. Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature. 2001;413(6852):165-71.
    • (2001) Nature , vol.413 , Issue.6852 , pp. 165-171
    • Diefenbach, A.1    Jensen, E.R.2    Jamieson, A.M.3    Raulet, D.H.4
  • 150
    • 84940367107 scopus 로고    scopus 로고
    • Combined immune checkpoint blockade
    • 1:CAS:528:DC%2BC2MXhsV2mur3F 26320068
    • Drake CG. Combined immune checkpoint blockade. Semin Oncol. 2015;42(4):656-62.
    • (2015) Semin Oncol , vol.42 , Issue.4 , pp. 656-662
    • Drake, C.G.1
  • 152
    • 45749134564 scopus 로고    scopus 로고
    • The anticancer immune response: Indispensable for therapeutic success?
    • 1:CAS:528:DC%2BD1cXntVCmtr8%3D 18523649 2396905
    • Zitvogel L, Apetoh L, Ghiringhelli F, Andre F, Tesniere A, Kroemer G. The anticancer immune response: indispensable for therapeutic success? J Clin Invest. 2008;118(6):1991-2001.
    • (2008) J Clin Invest , vol.118 , Issue.6 , pp. 1991-2001
    • Zitvogel, L.1    Apetoh, L.2    Ghiringhelli, F.3    Andre, F.4    Tesniere, A.5    Kroemer, G.6
  • 153
    • 84991619059 scopus 로고    scopus 로고
    • Immunogenic cell death in cancer and infectious disease
    • 1:CAS:528:DC%2BC28Xhs1ygtrjJ 27748397
    • Galluzzi L, Buque A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol. 2017;17(2):97-111.
    • (2017) Nat Rev Immunol , vol.17 , Issue.2 , pp. 97-111
    • Galluzzi, L.1    Buque, A.2    Kepp, O.3    Zitvogel, L.4    Kroemer, G.5
  • 154
    • 85023169455 scopus 로고    scopus 로고
    • Chemotherapeutic agent-mediated elimination of myeloid-derived suppressor cells
    • 28811975
    • Wang Z, Till B, Gao Q. Chemotherapeutic agent-mediated elimination of myeloid-derived suppressor cells. Oncoimmunology. 2017;6(7):e1331807.
    • (2017) Oncoimmunology , vol.6 , Issue.7 , pp. e1331807
    • Wang, Z.1    Till, B.2    Gao, Q.3
  • 155
    • 84863924314 scopus 로고    scopus 로고
    • Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: A current perspective
    • 1:CAS:528:DC%2BC38XhtVeltb%2FP 22761338 3399042
    • Le DT, Jaffee EM. Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective. Cancer Res. 2012;72(14):3439-44.
    • (2012) Cancer Res , vol.72 , Issue.14 , pp. 3439-3444
    • Le, D.T.1    Jaffee, E.M.2
  • 156
    • 77951086882 scopus 로고    scopus 로고
    • 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity
    • 1:CAS:528:DC%2BC3cXkslShsLk%3D 20388795
    • Vincent J, Mignot G, Chalmin F, Ladoire S, Bruchard M, Chevriaux A, Martin F, Apetoh L, Rebe C, Ghiringhelli F. 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity. Cancer Res. 2010;70(8):3052-61.
    • (2010) Cancer Res , vol.70 , Issue.8 , pp. 3052-3061
    • Vincent, J.1    Mignot, G.2    Chalmin, F.3    Ladoire, S.4    Bruchard, M.5    Chevriaux, A.6    Martin, F.7    Apetoh, L.8    Rebe, C.9    Ghiringhelli, F.10
  • 157
    • 25144466458 scopus 로고    scopus 로고
    • Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • 1:CAS:528:DC%2BD2MXhtVShsb3O 16166452
    • Suzuki E, Kapoor V, Jassar AS, Kaiser LR, Albelda SM. Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res. 2005;11(18):6713-21.
    • (2005) Clin Cancer Res , vol.11 , Issue.18 , pp. 6713-6721
    • Suzuki, E.1    Kapoor, V.2    Jassar, A.S.3    Kaiser, L.R.4    Albelda, S.M.5
  • 158
    • 84874232680 scopus 로고    scopus 로고
    • Antitumor effect of paclitaxel is mediated by inhibition of myeloid-derived suppressor cells and chronic inflammation in the spontaneous melanoma model
    • 1:CAS:528:DC%2BC3sXislOltrY%3D 23359505 3578135
    • Sevko A, Michels T, Vrohlings M, Umansky L, Beckhove P, Kato M, Shurin GV, Shurin MR, Umansky V. Antitumor effect of paclitaxel is mediated by inhibition of myeloid-derived suppressor cells and chronic inflammation in the spontaneous melanoma model. J Immunol. 2013;190(5):2464-71.
    • (2013) J Immunol , vol.190 , Issue.5 , pp. 2464-2471
    • Sevko, A.1    Michels, T.2    Vrohlings, M.3    Umansky, L.4    Beckhove, P.5    Kato, M.6    Shurin, G.V.7    Shurin, M.R.8    Umansky, V.9
  • 160
    • 80053353709 scopus 로고    scopus 로고
    • Prerequisites for the antitumor vaccine-like effect of chemotherapy and radiotherapy
    • 1:CAS:528:DC%2BC3MXhsVWjsL%2FJ 21952286
    • Hannani D, Sistigu A, Kepp O, Galluzzi L, Kroemer G, Zitvogel L. Prerequisites for the antitumor vaccine-like effect of chemotherapy and radiotherapy. Cancer J. 2011;17(5):351-8.
    • (2011) Cancer J , vol.17 , Issue.5 , pp. 351-358
    • Hannani, D.1    Sistigu, A.2    Kepp, O.3    Galluzzi, L.4    Kroemer, G.5    Zitvogel, L.6
  • 162
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
    • 1:CAS:528:DC%2BC38XhtVynsbvP 22547592
    • Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Neal J, Lu H, Cuillerot JM, Reck M. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol. 2012;30(17):2046-54.
    • (2012) J Clin Oncol , vol.30 , Issue.17 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6    Sebastian, M.7    Neal, J.8    Lu, H.9    Cuillerot, J.M.10    Reck, M.11
  • 163
    • 84983489005 scopus 로고    scopus 로고
    • Role of local radiation therapy in cancer immunotherapy
    • 26270858
    • Demaria S, Golden EB, Formenti SC. Role of local radiation therapy in cancer immunotherapy. JAMA Oncol. 2015;1(9):1325-32.
    • (2015) JAMA Oncol , vol.1 , Issue.9 , pp. 1325-1332
    • Demaria, S.1    Golden, E.B.2    Formenti, S.C.3
  • 165
    • 85003053854 scopus 로고    scopus 로고
    • An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer
    • 24563870 3930458
    • Golden EB, Demaria S, Schiff PB, Chachoua A, Formenti SC. An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res. 2013;1(6):365-72.
    • (2013) Cancer Immunol Res , vol.1 , Issue.6 , pp. 365-372
    • Golden, E.B.1    Demaria, S.2    Schiff, P.B.3    Chachoua, A.4    Formenti, S.C.5
  • 167
    • 84880508629 scopus 로고    scopus 로고
    • Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: Results from an open-label, multicenter phase I/II study
    • 1:STN:280:DC%2BC3srgt1Cmtg%3D%3D 23535954 3707423
    • Slovin SF, Higano CS, Hamid O, Tejwani S, Harzstark A, Alumkal JJ, Scher HI, Chin K, Gagnier P, McHenry MB, Beer TM. Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study. Ann Oncol. 2013;24(7):1813-21.
    • (2013) Ann Oncol , vol.24 , Issue.7 , pp. 1813-1821
    • Slovin, S.F.1    Higano, C.S.2    Hamid, O.3    Tejwani, S.4    Harzstark, A.5    Alumkal, J.J.6    Scher, H.I.7    Chin, K.8    Gagnier, P.9    McHenry, M.B.10    Beer, T.M.11
  • 169
    • 84877051042 scopus 로고    scopus 로고
    • Combining cancer immunotherapy and targeted therapy
    • 1:CAS:528:DC%2BC3sXlt1ejtb4%3D 23561594 3672064
    • Ribas A, Wolchok JD. Combining cancer immunotherapy and targeted therapy. Curr Opin Immunol. 2013;25(2):291-6.
    • (2013) Curr Opin Immunol , vol.25 , Issue.2 , pp. 291-296
    • Ribas, A.1    Wolchok, J.D.2
  • 177
    • 84883008576 scopus 로고    scopus 로고
    • BRAF inhibition improves tumor recognition by the immune system: Potential implications for combinatorial therapies against melanoma involving adoptive T-cell transfer
    • 23264894 3525603
    • Donia M, Fagone P, Nicoletti F, Andersen RS, Hogdall E, Straten PT, Andersen MH, Svane IM. BRAF inhibition improves tumor recognition by the immune system: potential implications for combinatorial therapies against melanoma involving adoptive T-cell transfer. Oncoimmunology. 2012;1(9):1476-83.
    • (2012) Oncoimmunology , vol.1 , Issue.9 , pp. 1476-1483
    • Donia, M.1    Fagone, P.2    Nicoletti, F.3    Andersen, R.S.4    Hogdall, E.5    Straten, P.T.6    Andersen, M.H.7    Svane, I.M.8
  • 178
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of vemurafenib and ipilimumab
    • 1:CAS:528:DC%2BC3sXls1aktbg%3D 23550685
    • Ribas A, Hodi FS, Callahan M, Konto C, Wolchok J. Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med. 2013;368(14):1365-6.
    • (2013) N Engl J Med , vol.368 , Issue.14 , pp. 1365-1366
    • Ribas, A.1    Hodi, F.S.2    Callahan, M.3    Konto, C.4    Wolchok, J.5
  • 181
    • 84880757177 scopus 로고    scopus 로고
    • Deciphering and reversing tumor immune suppression
    • 1:CAS:528:DC%2BC3sXhtFOht7%2FE 23890064 3782392
    • Motz GT, Coukos G. Deciphering and reversing tumor immune suppression. Immunity. 2013;39(1):61-73.
    • (2013) Immunity , vol.39 , Issue.1 , pp. 61-73
    • Motz, G.T.1    Coukos, G.2
  • 182
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • 1:CAS:528:DC%2BC3MXmvVegurs%3D 21629292
    • Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov. 2011;10(6):417-27.
    • (2011) Nat Rev Drug Discov , vol.10 , Issue.6 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 192
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • 1:CAS:528:DyaK1MXntlGlu7w%3D 10537366
    • Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin Cancer Res. 1999;5(10):2963-70.
    • (1999) Clin Cancer Res , vol.5 , Issue.10 , pp. 2963-2970
    • Gabrilovich, D.I.1    Ishida, T.2    Nadaf, S.3    Ohm, J.E.4    Carbone, D.P.5
  • 193
    • 84955300805 scopus 로고    scopus 로고
    • CTLA-4 blockade synergizes therapeutically with PARP inhibition in BRCA1-deficient ovarian cancer
    • 1:CAS:528:DC%2BC2MXhvVajsbvK 26138335 4984269
    • Higuchi T, Flies DB, Marjon NA, Mantia-Smaldone G, Ronner L, Gimotty PA, Adams SF. CTLA-4 blockade synergizes therapeutically with PARP inhibition in BRCA1-deficient ovarian cancer. Cancer Immunol Res. 2015;3(11):1257-68.
    • (2015) Cancer Immunol Res , vol.3 , Issue.11 , pp. 1257-1268
    • Higuchi, T.1    Flies, D.B.2    Marjon, N.A.3    Mantia-Smaldone, G.4    Ronner, L.5    Gimotty, P.A.6    Adams, S.F.7
  • 195
    • 85012023606 scopus 로고    scopus 로고
    • The principles of engineering immune cells to treat cancer
    • 1:CAS:528:DC%2BC2sXis1ygtLs%3D 28187291 5553442
    • Lim WA, June CH. The principles of engineering immune cells to treat cancer. Cell. 2017;168(4):724-40.
    • (2017) Cell , vol.168 , Issue.4 , pp. 724-740
    • Lim, W.A.1    June, C.H.2
  • 196
    • 85019723531 scopus 로고    scopus 로고
    • Therapeutic T cell engineering
    • 1:CAS:528:DC%2BC2sXosVansrc%3D 28541315 5632949
    • Sadelain M, Riviere I, Riddell S. Therapeutic T cell engineering. Nature. 2017;545(7655):423-31.
    • (2017) Nature , vol.545 , Issue.7655 , pp. 423-431
    • Sadelain, M.1    Riviere, I.2    Riddell, S.3
  • 197
    • 84979268324 scopus 로고    scopus 로고
    • Chimeric antigen receptors modified T-cells for cancer therapy
    • 26819347 4948566 1:CAS:528:DC%2BC1cXivFOku78%3D
    • Dai H, Wang Y, Lu X, Han W. Chimeric antigen receptors modified T-cells for cancer therapy. J Natl Cancer Inst. 2016;108(7):djv439.
    • (2016) J Natl Cancer Inst , vol.108 , Issue.7 , pp. djv439
    • Dai, H.1    Wang, Y.2    Lu, X.3    Han, W.4
  • 198
    • 85014216230 scopus 로고    scopus 로고
    • New development in CAR-T cell therapy
    • 28222796 5320663
    • Wang Z, Wu Z, Liu Y, Han W. New development in CAR-T cell therapy. J Hematol Oncol. 2017;10(1):53.
    • (2017) J Hematol Oncol , vol.10 , Issue.1 , pp. 53
    • Wang, Z.1    Wu, Z.2    Liu, Y.3    Han, W.4
  • 200
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • 1:CAS:528:DC%2BC3MXhtV2lu7nP 21830940 3387277
    • Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med. 2011;365(8):725-33.
    • (2011) N Engl J Med , vol.365 , Issue.8 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 201
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • 1:CAS:528:DC%2BC3MXjsFeqtrk%3D 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 202
    • 85021453088 scopus 로고    scopus 로고
    • Hallmarks of response to immune checkpoint blockade
    • 28524159 5520201
    • Cogdill AP, Andrews MC, Wargo JA. Hallmarks of response to immune checkpoint blockade. Br J Cancer. 2017;117(1):1-7.
    • (2017) Br J Cancer , vol.117 , Issue.1 , pp. 1-7
    • Cogdill, A.P.1    Andrews, M.C.2    Wargo, J.A.3
  • 203
    • 84867544962 scopus 로고    scopus 로고
    • PD-1 blockade enhances T-cell migration to tumors by elevating IFN-gamma inducible chemokines
    • 1:CAS:528:DC%2BC38XhsFWrs77I 22915761 3476734
    • Peng W, Liu C, Xu C, Lou Y, Chen J, Yang Y, Yagita H, Overwijk WW, Lizee G, Radvanyi L, Hwu P. PD-1 blockade enhances T-cell migration to tumors by elevating IFN-gamma inducible chemokines. Cancer Res. 2012;72(20):5209-18.
    • (2012) Cancer Res , vol.72 , Issue.20 , pp. 5209-5218
    • Peng, W.1    Liu, C.2    Xu, C.3    Lou, Y.4    Chen, J.5    Yang, Y.6    Yagita, H.7    Overwijk, W.W.8    Lizee, G.9    Radvanyi, L.10    Hwu, P.11
  • 204
    • 84922718852 scopus 로고    scopus 로고
    • Ctla-4 blockade plus adoptive T-cell transfer promotes optimal melanoma immunity in mice
    • 1:CAS:528:DC%2BC2MXisF2guro%3D 25658614 4321765
    • Mahvi DA, Meyers JV, Tatar AJ, Contreras A, Suresh M, Leverson GE, Sen S, Cho CS. Ctla-4 blockade plus adoptive T-cell transfer promotes optimal melanoma immunity in mice. J Immunother. 2015;38(2):54-61.
    • (2015) J Immunother , vol.38 , Issue.2 , pp. 54-61
    • Mahvi, D.A.1    Meyers, J.V.2    Tatar, A.J.3    Contreras, A.4    Suresh, M.5    Leverson, G.E.6    Sen, S.7    Cho, C.S.8
  • 206
    • 85017522496 scopus 로고    scopus 로고
    • Influence of ipilimumab on expanded tumour derived T cells from patients with metastatic melanoma
    • 28423678 5432318
    • Bjoern J, Lyngaa R, Andersen R, Rosenkrantz LH, Hadrup SR, Donia M, Svane IM. Influence of ipilimumab on expanded tumour derived T cells from patients with metastatic melanoma. Oncotarget. 2017;8(16):27062-74.
    • (2017) Oncotarget , vol.8 , Issue.16 , pp. 27062-27074
    • Bjoern, J.1    Lyngaa, R.2    Andersen, R.3    Rosenkrantz, L.H.4    Hadrup, S.R.5    Donia, M.6    Svane, I.M.7
  • 207
    • 84861224393 scopus 로고    scopus 로고
    • Tumor PD-L1 co-stimulates primary human CD8(+) cytotoxic T cells modified to express a PD1:CD28 chimeric receptor
    • 1:CAS:528:DC%2BC38XlsVaitr8%3D 22503210
    • Prosser ME, Brown CE, Shami AF, Forman SJ, Jensen MC. Tumor PD-L1 co-stimulates primary human CD8(+) cytotoxic T cells modified to express a PD1:CD28 chimeric receptor. Mol Immunol. 2012;51(3-4):263-72.
    • (2012) Mol Immunol , vol.51 , Issue.3-4 , pp. 263-272
    • Prosser, M.E.1    Brown, C.E.2    Shami, A.F.3    Forman, S.J.4    Jensen, M.C.5
  • 209
    • 85018387101 scopus 로고    scopus 로고
    • Multiplex genome editing to generate universal CAR T cells resistant to PD1 inhibition
    • 1:CAS:528:DC%2BC2sXmvFegsrc%3D 27815355
    • Ren J, Liu X, Fang C, Jiang S, June CH, Zhao Y. Multiplex genome editing to generate universal CAR T cells resistant to PD1 inhibition. Clin Cancer Res. 2017;23(9):2255-66.
    • (2017) Clin Cancer Res , vol.23 , Issue.9 , pp. 2255-2266
    • Ren, J.1    Liu, X.2    Fang, C.3    Jiang, S.4    June, C.H.5    Zhao, Y.6
  • 210
    • 84973640899 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model
    • 27145284 5085160
    • Suarez ER, Chang de K, Sun J, Sui J, Freeman GJ, Signoretti S, Zhu Q, Marasco WA. Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model. Oncotarget. 2016;7(23):34341-55.
    • (2016) Oncotarget , vol.7 , Issue.23 , pp. 34341-34355
    • Suarez, E.R.1    De, C.K.2    Sun, J.3    Sui, J.4    Freeman, G.J.5    Signoretti, S.6    Zhu, Q.7    Marasco, W.A.8
  • 211
    • 77957830553 scopus 로고    scopus 로고
    • Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice
    • 1:CAS:528:DC%2BC3cXht1Ggtb7L 20890046 2947221
    • Stromnes IM, Blattman JN, Tan X, Jeevanjee S, Gu H, Greenberg PD. Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice. J Clin Invest. 2010;120(10):3722-34.
    • (2010) J Clin Invest , vol.120 , Issue.10 , pp. 3722-3734
    • Stromnes, I.M.1    Blattman, J.N.2    Tan, X.3    Jeevanjee, S.4    Gu, H.5    Greenberg, P.D.6
  • 213
    • 84858759305 scopus 로고    scopus 로고
    • Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
    • 1:CAS:528:DC%2BC38XmvV2rsLg%3D 22354001 3359735
    • Pegram HJ, Lee JC, Hayman EG, Imperato GH, Tedder TF, Sadelain M, Brentjens RJ. Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood. 2012;119(18):4133-41.
    • (2012) Blood , vol.119 , Issue.18 , pp. 4133-4141
    • Pegram, H.J.1    Lee, J.C.2    Hayman, E.G.3    Imperato, G.H.4    Tedder, T.F.5    Sadelain, M.6    Brentjens, R.J.7
  • 215
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • 1:CAS:528:DC%2BD38XksFOmsrw%3D 12042769
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002;3(6):415-28.
    • (2002) Nat Rev Genet , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 216
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • 1:CAS:528:DC%2BD2sXivVGktbk%3D 17339880
    • Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet. 2007;8(4):286-98.
    • (2007) Nat Rev Genet , vol.8 , Issue.4 , pp. 286-298
    • Esteller, M.1
  • 217
    • 0035839057 scopus 로고    scopus 로고
    • The role of DNA methylation in mammalian epigenetics
    • 1:CAS:528:DC%2BD3MXmtVWlsbY%3D 11498573
    • Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science. 2001;293(5532):1068-70.
    • (2001) Science , vol.293 , Issue.5532 , pp. 1068-1070
    • Jones, P.A.1    Takai, D.2
  • 218
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • 1:CAS:528:DC%2BD2sXis12ju7Y%3D 17320507
    • Kouzarides T. Chromatin modifications and their function. Cell. 2007;128(4):693-705.
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 221
    • 84983294422 scopus 로고    scopus 로고
    • HDAC inhibitors with PD-1 blockade: A promising strategy for treatment of multiple cancer types?
    • 1:CAS:528:DC%2BC28XhtlCisr3I 27410519
    • Beg AA, Gray JE. HDAC inhibitors with PD-1 blockade: a promising strategy for treatment of multiple cancer types? Epigenomics. 2016;8(8):1015-7.
    • (2016) Epigenomics , vol.8 , Issue.8 , pp. 1015-1017
    • Beg, A.A.1    Gray, J.E.2
  • 223
    • 84962189576 scopus 로고    scopus 로고
    • HDAC inhibition upregulates PD-1 ligands in melanoma and augments immunotherapy with PD-1 blockade
    • 1:CAS:528:DC%2BC2MXhvF2lu7zO 26297712 4674300
    • Woods DM, Sodre AL, Villagra A, Sarnaik A, Sotomayor EM, Weber J. HDAC inhibition upregulates PD-1 ligands in melanoma and augments immunotherapy with PD-1 blockade. Cancer Immunol Res. 2015;3(12):1375-85.
    • (2015) Cancer Immunol Res , vol.3 , Issue.12 , pp. 1375-1385
    • Woods, D.M.1    Sodre, A.L.2    Villagra, A.3    Sarnaik, A.4    Sotomayor, E.M.5    Weber, J.6
  • 225
    • 84962018342 scopus 로고    scopus 로고
    • Decitabine enhances lymphocyte migration and function and synergizes with CTLA-4 blockade in a murine ovarian cancer model
    • 1:CAS:528:DC%2BC2MXhsFartL7F 26056145
    • Wang L, Amoozgar Z, Huang J, Saleh MH, Xing D, Orsulic S, Goldberg MS. Decitabine enhances lymphocyte migration and function and synergizes with CTLA-4 blockade in a murine ovarian cancer model. Cancer Immunol Res. 2015;3(9):1030-41.
    • (2015) Cancer Immunol Res , vol.3 , Issue.9 , pp. 1030-1041
    • Wang, L.1    Amoozgar, Z.2    Huang, J.3    Saleh, M.H.4    Xing, D.5    Orsulic, S.6    Goldberg, M.S.7
  • 228
    • 85019207258 scopus 로고    scopus 로고
    • Epigenetics and immunotherapy: The current state of play
    • 1:CAS:528:DC%2BC2sXns1ymtr0%3D 28511092
    • Dunn J, Rao S. Epigenetics and immunotherapy: the current state of play. Mol Immunol. 2017;87:227-39.
    • (2017) Mol Immunol , vol.87 , pp. 227-239
    • Dunn, J.1    Rao, S.2
  • 230
    • 84926475466 scopus 로고    scopus 로고
    • Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: Clinical significance and progress to date
    • 1:CAS:528:DC%2BC2MXlvFSju7c%3D 25418875
    • Mould DP, McGonagle AE, Wiseman DH, Williams EL, Jordan AM. Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date. Med Res Rev. 2015;35(3):586-618.
    • (2015) Med Res Rev , vol.35 , Issue.3 , pp. 586-618
    • Mould, D.P.1    McGonagle, A.E.2    Wiseman, D.H.3    Williams, E.L.4    Jordan, A.M.5
  • 231
    • 84962788254 scopus 로고    scopus 로고
    • Microbiome and anticancer immunosurveillance
    • 1:CAS:528:DC%2BC28Xlslers7Y%3D 27058662
    • Zitvogel L, Ayyoub M, Routy B, Kroemer G. Microbiome and anticancer immunosurveillance. Cell. 2016;165(2):276-87.
    • (2016) Cell , vol.165 , Issue.2 , pp. 276-287
    • Zitvogel, L.1    Ayyoub, M.2    Routy, B.3    Kroemer, G.4
  • 232
    • 84905858666 scopus 로고    scopus 로고
    • Systematic review: The role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis - Current evidence and potential clinical applications
    • 1:STN:280:DC%2BC2cbjvVGltw%3D%3D 25040088
    • Touchefeu Y, Montassier E, Nieman K, Gastinne T, Potel G, Bruley des Varannes S, Le Vacon F, de La Cochetiere MF. Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis - current evidence and potential clinical applications. Aliment Pharmacol Ther. 2014;40(5):409-21.
    • (2014) Aliment Pharmacol Ther , vol.40 , Issue.5 , pp. 409-421
    • Touchefeu, Y.1    Montassier, E.2    Nieman, K.3    Gastinne, T.4    Potel, G.5    Bruley Des Varannes, S.6    Le Vacon, F.7    De La Cochetiere, M.F.8
  • 238
    • 84864052441 scopus 로고    scopus 로고
    • Management of immune-related adverse events and kinetics of response with ipilimumab
    • 1:CAS:528:DC%2BC38Xht1ygsr%2FK 22614989
    • Weber JS, Kahler KC, Hauschild A. Management of immune-related adverse events and kinetics of response with ipilimumab. J Clin Oncol. 2012;30(21):2691-7.
    • (2012) J Clin Oncol , vol.30 , Issue.21 , pp. 2691-2697
    • Weber, J.S.1    Kahler, K.C.2    Hauschild, A.3


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