메뉴 건너뛰기




Volumn 108, Issue 7, 2016, Pages

Chimeric antigen receptors modified T-cells for cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC ANTIGEN RECEPTOR; CD19 ANTIGEN; CYTOKINE; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84979268324     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djv439     Document Type: Review
Times cited : (238)

References (162)
  • 1
    • 0033092413 scopus 로고    scopus 로고
    • A commotion in the blood: Life, death, and the immune system
    • Soderqvist T, Stillwell C. A commotion in the blood: Life, death, and the immune system. J Hist Biol. 1999;32(1):205-215.
    • (1999) J Hist Biol. , vol.32 , Issue.1 , pp. 205-215
    • Soderqvist, T.1    Stillwell, C.2
  • 2
    • 0141688283 scopus 로고    scopus 로고
    • Adoptive-cell-transfer therapy for the treatment of patients with cancer
    • Dudley ME, Rosenberg SA. Adoptive-cell-transfer therapy for the treatment of patients with cancer. Nat Rev Cancer. 2003;3(9):666-675.
    • (2003) Nat Rev Cancer. , vol.3 , Issue.9 , pp. 666-675
    • Dudley, M.E.1    Rosenberg, S.A.2
  • 3
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • Rosenberg SA, Yang JC, Sherry RM, et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res. 2011;17(13):4550-4557.
    • (2011) Clin Cancer Res. , vol.17 , Issue.13 , pp. 4550-4557
    • Rosenberg, S.A.1    Yang, J.C.2    Sherry, R.M.3
  • 4
    • 55549145071 scopus 로고    scopus 로고
    • Virus-specific T-cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
    • Pule MA, Savoldo B, Myers GD, et al. Virus-specific T-cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med. 2008;14(11):1264-1270.
    • (2008) Nat Med. , vol.14 , Issue.11 , pp. 1264-1270
    • Pule, M.A.1    Savoldo, B.2    Myers, G.D.3
  • 5
    • 80051775476 scopus 로고    scopus 로고
    • T-cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • Kalos M, Levine BL, Porter DL, et al. T-cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia. Science Transl Med. 2011;3(95):95ra73.
    • (2011) Science Transl Med. , vol.3 , Issue.95 , pp. 95ra73
    • Kalos, M.1    Levine, B.L.2    Porter, D.L.3
  • 6
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T-cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, et al. Chimeric antigen receptor-modified T-cells in chronic lymphoid leukemia. N Engl J Med. 2011;365(8):725-733.
    • (2011) N Engl J Med. , vol.365 , Issue.8 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3
  • 7
    • 84876005284 scopus 로고    scopus 로고
    • CD19-targeted T-cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
    • Brentjens RJ, Davila ML, Riviere I, et al. CD19-targeted T-cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med. 2013;5(177):177ra38.
    • (2013) Sci Transl Med. , vol.5 , Issue.177 , pp. 177ra38
    • Brentjens, R.J.1    Davila, M.L.2    Riviere, I.3
  • 8
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T-cells for acute lymphoid leukemia
    • Grupp SA, Kalos M, Barrett D, et al. Chimeric antigen receptor-modified T-cells for acute lymphoid leukemia. N Engl J Med. 2013;368(16):1509-1518.
    • (2013) N Engl J Med. , vol.368 , Issue.16 , pp. 1509-1518
    • Grupp, S.A.1    Kalos, M.2    Barrett, D.3
  • 9
    • 84908073316 scopus 로고    scopus 로고
    • Chimeric antigen receptor T-cells for sustained remissions in leukemia
    • Maude SL, Frey N, Shaw PA, et al. Chimeric antigen receptor T-cells for sustained remissions in leukemia. N Engl J Med. 2014;371(16):1507-1517.
    • (2014) N Engl J Med. , vol.371 , Issue.16 , pp. 1507-1517
    • Maude, S.L.1    Frey, N.2    Shaw, P.A.3
  • 10
    • 84923019006 scopus 로고    scopus 로고
    • T-cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial
    • Lee DW, Kochenderfer JN, Stetler-Stevenson M, et al. T-cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet. 2015;385(9967):517-528.
    • (2015) Lancet. , vol.385 , Issue.9967 , pp. 517-528
    • Lee, D.W.1    Kochenderfer, J.N.2    Stetler-Stevenson, M.3
  • 11
    • 84940881287 scopus 로고    scopus 로고
    • Chimeric antigen receptor T-cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
    • Porter DL, Hwang WT, Frey NV, et al. Chimeric antigen receptor T-cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Sci Transl Med. 2015;7(303):303ra139.
    • (2015) Sci Transl Med. , vol.7 , Issue.303 , pp. 303ra139
    • Porter, D.L.1    Hwang, W.T.2    Frey, N.V.3
  • 12
    • 84933513655 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 (HER2) -specific chimeric antigen receptor-modified t-cells for the immunotherapy of HER2-positive sarcoma
    • Ahmed N, Brawley VS, Hegde M, et al. Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T-cells for the Immunotherapy of HER2-Positive Sarcoma. J Clin Oncol. 2015;33(15):1688-1696.
    • (2015) J Clin Oncol. , vol.33 , Issue.15 , pp. 1688-1696
    • Ahmed, N.1    Brawley, V.S.2    Hegde, M.3
  • 13
    • 0035251532 scopus 로고    scopus 로고
    • Functional expression of chimeric receptor genes in human T-cells
    • Eshhar Z, Waks T, Bendavid A, et al. Functional expression of chimeric receptor genes in human T-cells. J Immunol Methods. 2001;248(1-2):67-76.
    • (2001) J Immunol Methods. , vol.248 , Issue.1-2 , pp. 67-76
    • Eshhar, Z.1    Waks, T.2    Bendavid, A.3
  • 14
    • 84862272378 scopus 로고    scopus 로고
    • Towards curative cancer immunotherapy: Overcoming posttherapy tumor escape
    • Zhou G, Levitsky H. Towards curative cancer immunotherapy: overcoming posttherapy tumor escape. Clin Dev Immunol. 2012;2012:124187.
    • (2012) Clin Dev Immunol. , vol.2012 , pp. 124187
    • Zhou, G.1    Levitsky, H.2
  • 15
    • 33947285535 scopus 로고    scopus 로고
    • Immunoediting sculpts tumor epitopes during immunotherapy
    • Singh R, Paterson Y. Immunoediting sculpts tumor epitopes during immunotherapy. Cancer Res. 2007;67(5):1887-1892.
    • (2007) Cancer Res. , vol.67 , Issue.5 , pp. 1887-1892
    • Singh, R.1    Paterson, Y.2
  • 16
    • 68049118980 scopus 로고    scopus 로고
    • Loss of mismatched HLA in leukemia after stem-cell transplantation
    • Vago L, Perna SK, Zanussi M, et al. Loss of mismatched HLA in leukemia after stem-cell transplantation. N Engl J Med. 2009;361(5):478-488.
    • (2009) N Engl J Med. , vol.361 , Issue.5 , pp. 478-488
    • Vago, L.1    Perna, S.K.2    Zanussi, M.3
  • 17
    • 0030777395 scopus 로고    scopus 로고
    • T-cell targeting of TAG72+ tumor cells by a chimeric receptor with antibody-like specificity for a carbohydrate epitope
    • Hombach A, Heuser C, Sircar R, et al. T-cell targeting of TAG72+ tumor cells by a chimeric receptor with antibody-like specificity for a carbohydrate epitope. Gastroenterology. 1997;113(4):1163-1170.
    • (1997) Gastroenterology. , vol.113 , Issue.4 , pp. 1163-1170
    • Hombach, A.1    Heuser, C.2    Sircar, R.3
  • 18
    • 30044442768 scopus 로고    scopus 로고
    • Adoptive transfer of T-cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Yexpressing tumors in mice
    • Westwood JA, Smyth MJ, Teng MW, et al. Adoptive transfer of T-cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Yexpressing tumors in mice. Proc Natl Acad Sci U S A. 2005;102(52):19051-19056.
    • (2005) Proc Natl Acad Sci U S A. , vol.102 , Issue.52 , pp. 19051-19056
    • Westwood, J.A.1    Smyth, M.J.2    Teng, M.W.3
  • 19
    • 0035888244 scopus 로고    scopus 로고
    • Targeting of G(D2)-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes
    • Rossig C, Bollard CM, Nuchtern JG, et al. Targeting of G(D2)-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes. Int J Cancer. 2001;94(2):228-236.
    • (2001) Int J Cancer. , vol.94 , Issue.2 , pp. 228-236
    • Rossig, C.1    Bollard, C.M.2    Nuchtern, J.G.3
  • 20
    • 82955207691 scopus 로고    scopus 로고
    • Antitumor activity and long-term fate of chimeric antigen receptor-positive T-cells in patients with neuroblastoma
    • Louis CU, Savoldo B, Dotti G, et al. Antitumor activity and long-term fate of chimeric antigen receptor-positive T-cells in patients with neuroblastoma. Blood. 2011;118(23):6050-6056.
    • (2011) Blood. , vol.118 , Issue.23 , pp. 6050-6056
    • Louis, C.U.1    Savoldo, B.2    Dotti, G.3
  • 21
    • 0035226813 scopus 로고    scopus 로고
    • A novel strategy in the elimination of disseminated melanoma cells: Chimeric receptors endow T-cells with tumor specificity
    • Abken H, Hombach A, Heuser C, et al. A novel strategy in the elimination of disseminated melanoma cells: chimeric receptors endow T-cells with tumor specificity. Recent Results Cancer Res. 2001;158:249-264.
    • (2001) Recent Results Cancer Res. , vol.158 , pp. 249-264
    • Abken, H.1    Hombach, A.2    Heuser, C.3
  • 22
    • 44449162630 scopus 로고    scopus 로고
    • Retargeting of human T-cells to tumorassociated MUC1: The evolution of a chimeric antigen receptor
    • Wilkie S, Picco G, Foster J, et al. Retargeting of human T-cells to tumorassociated MUC1: the evolution of a chimeric antigen receptor. J Immunol. 2008;180(7):4901-4909.
    • (2008) J Immunol. , vol.180 , Issue.7 , pp. 4901-4909
    • Wilkie, S.1    Picco, G.2    Foster, J.3
  • 23
    • 77954712252 scopus 로고    scopus 로고
    • Successful eradication of established peritoneal ovarian tumors in SCID-Beige mice following adoptive transfer of T-cells genetically targeted to the MUC16 antigen
    • Chekmasova AA, Rao TD, Nikhamin Y, et al. Successful eradication of established peritoneal ovarian tumors in SCID-Beige mice following adoptive transfer of T-cells genetically targeted to the MUC16 antigen. Clin Cancer Res. 2010;16(14):3594-3606.
    • (2010) Clin Cancer Res. , vol.16 , Issue.14 , pp. 3594-3606
    • Chekmasova, A.A.1    Rao, T.D.2    Nikhamin, Y.3
  • 24
    • 84887471195 scopus 로고    scopus 로고
    • Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T-cells in glioblastoma
    • Hegde M, Corder A, Chow KK, et al. Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T-cells in glioblastoma. Mol Ther. 2013;21(11):2087-2101.
    • (2013) Mol Ther. , vol.21 , Issue.11 , pp. 2087-2101
    • Hegde, M.1    Corder, A.2    Chow, K.K.3
  • 25
    • 84859383718 scopus 로고    scopus 로고
    • A universal strategy for adoptive immunotherapy of cancer through use of a novel T-cell antigen receptor
    • Urbanska K, Lanitis E, Poussin M, et al. A universal strategy for adoptive immunotherapy of cancer through use of a novel T-cell antigen receptor. Cancer Res. 2012;72(7):1844-1852.
    • (2012) Cancer Res. , vol.72 , Issue.7 , pp. 1844-1852
    • Urbanska, K.1    Lanitis, E.2    Poussin, M.3
  • 26
    • 84870309981 scopus 로고    scopus 로고
    • Redirecting gene-modified T-cells toward various cancer types using tagged antibodies
    • Tamada K, Geng D, Sakoda Y, et al. Redirecting gene-modified T-cells toward various cancer types using tagged antibodies. Clin Cancer Res. 2012;18(23):6436-6445.
    • (2012) Clin Cancer Res. , vol.18 , Issue.23 , pp. 6436-6445
    • Tamada, K.1    Geng, D.2    Sakoda, Y.3
  • 27
    • 84880259439 scopus 로고    scopus 로고
    • TanCAR: A novel bispecific chimeric antigen receptor for cancer immunotherapy
    • Grada Z, Hegde M, Byrd T, et al. TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy. Mol Ther Nucleic Acids. 2013;2:e105.
    • (2013) Mol Ther Nucleic Acids. , vol.2 , pp. e105
    • Grada, Z.1    Hegde, M.2    Byrd, T.3
  • 28
    • 0028879071 scopus 로고
    • A spacer region between the single chain antibodyand the CD3 zeta-chain domain of chimeric T-cell receptor components is required for efficient ligand binding and signaling activity
    • Moritz D, Groner B. A spacer region between the single chain antibodyand the CD3 zeta-chain domain of chimeric T-cell receptor components is required for efficient ligand binding and signaling activity. Gene Ther. 1995;2(8):539-546.
    • (1995) Gene Ther. , vol.2 , Issue.8 , pp. 539-546
    • Moritz, D.1    Groner, B.2
  • 29
    • 77957980319 scopus 로고    scopus 로고
    • Adoptive immunotherapy with genetically engineered T-cells: Modification of the IgG1 Fc 'spacer' domain in the extracellular moiety of chimeric antigen receptors avoids 'off-target' activation and unintended initiation of an innate immune response
    • Hombach A, Hombach AA, Abken H. Adoptive immunotherapy with genetically engineered T-cells: modification of the IgG1 Fc 'spacer' domain in the extracellular moiety of chimeric antigen receptors avoids 'off-target' activation and unintended initiation of an innate immune response. Gene Ther. 2010;17(10):1206-1213.
    • (2010) Gene Ther. , vol.17 , Issue.10 , pp. 1206-1213
    • Hombach, A.1    Hombach, A.A.2    Abken, H.3
  • 30
    • 0024377117 scopus 로고
    • Adoptive immunotherapy with interleukin- 2 (IL-2) results in diminished IL-2 production by stimulated peripheral blood lymphocytes
    • Kradin R, Kurnick J, Gifford J, et al. Adoptive immunotherapy with interleukin- 2 (IL-2) results in diminished IL-2 production by stimulated peripheral blood lymphocytes. J Clin Immunol. 1989;9(5):378-385.
    • (1989) J Clin Immunol. , vol.9 , Issue.5 , pp. 378-385
    • Kradin, R.1    Kurnick, J.2    Gifford, J.3
  • 31
    • 45549093089 scopus 로고    scopus 로고
    • Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane
    • James SE, Greenberg PD, Jensen MC, et al. Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane. J Immunol. 2008;180(10):7028-7038.
    • (2008) J Immunol. , vol.180 , Issue.10 , pp. 7028-7038
    • James, S.E.1    Greenberg, P.D.2    Jensen, M.C.3
  • 32
    • 84874027123 scopus 로고    scopus 로고
    • Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
    • Haso W, Lee DW, Shah NN, et al. Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood. 2013;121(7):1165-1174.
    • (2013) Blood. , vol.121 , Issue.7 , pp. 1165-1174
    • Haso, W.1    Lee, D.W.2    Shah, N.N.3
  • 33
    • 20944439742 scopus 로고    scopus 로고
    • The role of extracellular spacer regions in the optimal design of chimeric immune receptors: Evaluation of four different scFvs and antigens
    • Guest RD, Hawkins RE, Kirillova N, et al. The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens. J Immunother. 2005;28(3):203-211.
    • (2005) J Immunother. , vol.28 , Issue.3 , pp. 203-211
    • Guest, R.D.1    Hawkins, R.E.2    Kirillova, N.3
  • 34
    • 80053130680 scopus 로고    scopus 로고
    • New insights into the T-cell synapse from single molecule techniques
    • Dustin ML, Depoil D. New insights into the T-cell synapse from single molecule techniques. Nat Rev Immunol. 2011;11(10):672-684.
    • (2011) Nat Rev Immunol. , vol.11 , Issue.10 , pp. 672-684
    • Dustin, M.L.1    Depoil, D.2
  • 35
    • 10844296758 scopus 로고    scopus 로고
    • Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T-cells
    • Kahlon KS, Brown C, Cooper LJ, et al. Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T-cells. Cancer Res. 2004;64(24):9160-9166.
    • (2004) Cancer Res. , vol.64 , Issue.24 , pp. 9160-9166
    • Kahlon, K.S.1    Brown, C.2    Cooper, L.J.3
  • 36
    • 70350726110 scopus 로고    scopus 로고
    • Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T-cells and increased antileukemic efficacy in vivo
    • Milone MC, Fish JD, Carpenito C, et al. Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T-cells and increased antileukemic efficacy in vivo. Mol Ther. 2009;17(8):1453-1464.
    • (2009) Mol Ther. , vol.17 , Issue.8 , pp. 1453-1464
    • Milone, M.C.1    Fish, J.D.2    Carpenito, C.3
  • 37
    • 84886944957 scopus 로고    scopus 로고
    • OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4(+) T-cells
    • Hombach AA, Heiders J, Foppe M, et al. OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4(+) T-cells. Oncoimmunology. 2012;1(4):458-466.
    • (2012) Oncoimmunology. , vol.1 , Issue.4 , pp. 458-466
    • Hombach, A.A.1    Heiders, J.2    Foppe, M.3
  • 38
    • 79959914449 scopus 로고    scopus 로고
    • In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T-cells is enhanced by costimulatory signaling through CD137 (4-1BB)
    • Song DG, Ye Q, Carpenito C, et al. In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T-cells is enhanced by costimulatory signaling through CD137 (4-1BB). Cancer Res. 2011;71(13):4617-4627.
    • (2011) Cancer Res. , vol.71 , Issue.13 , pp. 4617-4627
    • Song, D.G.1    Ye, Q.2    Carpenito, C.3
  • 39
    • 74949124101 scopus 로고    scopus 로고
    • 4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T-cells against B-cell malignancies
    • Tammana S, Huang X, Wong M, et al. 4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T-cells against B-cell malignancies. Hum Gene Ther. 2010;21(1):75-86.
    • (2010) Hum Gene Ther. , vol.21 , Issue.1 , pp. 75-86
    • Tammana, S.1    Huang, X.2    Wong, M.3
  • 40
    • 27744566329 scopus 로고    scopus 로고
    • A chimeric T-cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T-cells
    • Pule MA, Straathof KC, Dotti G, et al. A chimeric T-cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T-cells. Mol Ther. 2005;12(5):933-941.
    • (2005) Mol Ther. , vol.12 , Issue.5 , pp. 933-941
    • Pule, M.A.1    Straathof, K.C.2    Dotti, G.3
  • 41
    • 0026064305 scopus 로고
    • The cytoplasmic domain of the T-cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways
    • Irving BA, Weiss A. The cytoplasmic domain of the T-cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways. Cell. 1991;64(5):891-901.
    • (1991) Cell. , vol.64 , Issue.5 , pp. 891-901
    • Irving, B.A.1    Weiss, A.2
  • 42
    • 0025998529 scopus 로고
    • T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins
    • Letourneur F, Klausner RD. T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins. Proc Natl Acad Sci U S A. 1991;88(20):8905-8909.
    • (1991) Proc Natl Acad Sci U S A. , vol.88 , Issue.20 , pp. 8905-8909
    • Letourneur, F.1    Klausner, R.D.2
  • 43
    • 0026537801 scopus 로고
    • Sequence requirements for induction of cytolysis by the T-cell antigen/Fc receptor zeta chain
    • Romeo C, Amiot M, Seed B. Sequence requirements for induction of cytolysis by the T-cell antigen/Fc receptor zeta chain. Cell. 1992;68(5):889-897.
    • (1992) Cell. , vol.68 , Issue.5 , pp. 889-897
    • Romeo, C.1    Amiot, M.2    Seed, B.3
  • 44
    • 3042551216 scopus 로고    scopus 로고
    • Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
    • Imai C, Mihara K, Andreansky M, et al. Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia. 2004;18(4):676-684.
    • (2004) Leukemia. , vol.18 , Issue.4 , pp. 676-684
    • Imai, C.1    Mihara, K.2    Andreansky, M.3
  • 45
    • 0036137615 scopus 로고    scopus 로고
    • Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta /CD28 receptor
    • Maher J, Brentjens RJ, Gunset G, et al. Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta /CD28 receptor. Nat Biotechnol. 2002;20(1):70-75.
    • (2002) Nat Biotechnol. , vol.20 , Issue.1 , pp. 70-75
    • Maher, J.1    Brentjens, R.J.2    Gunset, G.3
  • 46
    • 33845294816 scopus 로고    scopus 로고
    • CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T-cells
    • Kowolik CM, Topp MS, Gonzalez S, et al. CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T-cells. Cancer Res. 2006;66(22):10995-11004.
    • (2006) Cancer Res. , vol.66 , Issue.22 , pp. 10995-11004
    • Kowolik, C.M.1    Topp, M.S.2    Gonzalez, S.3
  • 47
    • 0347994955 scopus 로고    scopus 로고
    • Activation of resting human primary T-cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain
    • Finney HM, Akbar AN, Lawson AD. Activation of resting human primary T-cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol. 2004;172(1):104-113.
    • (2004) J Immunol. , vol.172 , Issue.1 , pp. 104-113
    • Finney, H.M.1    Akbar, A.N.2    Lawson, A.D.3
  • 48
    • 84856071702 scopus 로고    scopus 로고
    • CD27 costimulation augments the survival and antitumor activity of redirected human T-cells in vivo
    • Song DG, Ye Q, Poussin M, et al. CD27 costimulation augments the survival and antitumor activity of redirected human T-cells in vivo. Blood. 2012;119(3):696-706.
    • (2012) Blood. , vol.119 , Issue.3 , pp. 696-706
    • Song, D.G.1    Ye, Q.2    Poussin, M.3
  • 49
    • 79958097537 scopus 로고    scopus 로고
    • 2B4 (CD244) signaling via chimeric receptors costimulates tumor-antigen specific proliferation and in vitro expansion of human T-cells
    • Altvater B, Landmeier S, Pscherer S, et al. 2B4 (CD244) signaling via chimeric receptors costimulates tumor-antigen specific proliferation and in vitro expansion of human T-cells. Cancer Immunol Immunother. 2009;58(12):1991-2001.
    • (2009) Cancer Immunol Immunother. , vol.58 , Issue.12 , pp. 1991-2001
    • Altvater, B.1    Landmeier, S.2    Pscherer, S.3
  • 50
    • 84930765209 scopus 로고    scopus 로고
    • 4-1BB costimulation ameliorates T-cell exhaustion induced by tonic signaling of chimeric antigen receptors
    • Long AH, Haso WM, Shern JF, et al. 4-1BB costimulation ameliorates T-cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nat Med. 2015;21(6):581-590.
    • (2015) Nat Med. , vol.21 , Issue.6 , pp. 581-590
    • Long, A.H.1    Haso, W.M.2    Shern, J.F.3
  • 51
    • 76349087378 scopus 로고    scopus 로고
    • Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/ Bcl-XL activation and CD8+ T-cell-mediated tumor eradication
    • Zhong XS, Matsushita M, Plotkin J, et al. Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/ Bcl-XL activation and CD8+ T-cell-mediated tumor eradication. Mol Ther. 2010;18(2):413-420.
    • (2010) Mol Ther. , vol.18 , Issue.2 , pp. 413-420
    • Zhong, X.S.1    Matsushita, M.2    Plotkin, J.3
  • 52
    • 78649977194 scopus 로고    scopus 로고
    • Tumor ablation by gene-modified T-cells in the absence of autoimmunity
    • Wang LX, Westwood JA, Moeller M, et al. Tumor ablation by gene-modified T-cells in the absence of autoimmunity. Cancer Res. 2010;70(23):9591-9598.
    • (2010) Cancer Res. , vol.70 , Issue.23 , pp. 9591-9598
    • Wang, L.X.1    Westwood, J.A.2    Moeller, M.3
  • 53
    • 62549097817 scopus 로고    scopus 로고
    • Control of large, established tumor xenografts with genetically retargeted human T-cells containing CD28 and CD137 domains
    • Carpenito C, Milone MC, Hassan R, et al. Control of large, established tumor xenografts with genetically retargeted human T-cells containing CD28 and CD137 domains. Proc Natl Acad Sci U S A. 2009;106(9):3360-3365.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , Issue.9 , pp. 3360-3365
    • Carpenito, C.1    Milone, M.C.2    Hassan, R.3
  • 54
    • 80052257433 scopus 로고    scopus 로고
    • IL-12 release by engineered T-cells expressing chimeric antigen receptors can effectively Muster an antigen- independent macrophage response on tumor cells that have shut down tumor antigen expression
    • Chmielewski M, Kopecky C, Hombach AA, et al. IL-12 release by engineered T-cells expressing chimeric antigen receptors can effectively Muster an antigen- independent macrophage response on tumor cells that have shut down tumor antigen expression. Cancer Res. 2011;71(17):5697-5706.
    • (2011) Cancer Res. , vol.71 , Issue.17 , pp. 5697-5706
    • Chmielewski, M.1    Kopecky, C.2    Hombach, A.A.3
  • 55
    • 84858759305 scopus 로고    scopus 로고
    • Tumor-targeted T-cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
    • Pegram HJ, Lee JC, Hayman EG, et al. Tumor-targeted T-cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood. 2012;119(18):4133-4141.
    • (2012) Blood. , vol.119 , Issue.18 , pp. 4133-4141
    • Pegram, H.J.1    Lee, J.C.2    Hayman, E.G.3
  • 56
    • 77954590000 scopus 로고    scopus 로고
    • Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/ leukemia effects and safety
    • Hoyos V, Savoldo B, Quintarelli C, et al. Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/ leukemia effects and safety. Leukemia. 2010;24(6):1160-1170.
    • (2010) Leukemia. , vol.24 , Issue.6 , pp. 1160-1170
    • Hoyos, V.1    Savoldo, B.2    Quintarelli, C.3
  • 57
    • 84944034504 scopus 로고    scopus 로고
    • Structural design of engineered costimulation determines tumor rejection kinetics and persistence of CAR T-cells
    • Zhao Z, Condomines M, van der Stegen SJ, et al. Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T-cells. Cancer Cell. 2015;28(4):415-428.
    • (2015) Cancer Cell. , vol.28 , Issue.4 , pp. 415-428
    • Zhao, Z.1    Condomines, M.2    Van Der Stegen, S.J.3
  • 58
    • 84927070775 scopus 로고    scopus 로고
    • Enhancing antitumor efficacy of chimeric antigen receptor T-cells through constitutive CD40L expression
    • Curran KJ, Seinstra BA, Nikhamin Y, et al. Enhancing antitumor efficacy of chimeric antigen receptor T-cells through constitutive CD40L expression. Mol Ther. 2015;23(4):769-778.
    • (2015) Mol Ther. , vol.23 , Issue.4 , pp. 769-778
    • Curran, K.J.1    Seinstra, B.A.2    Nikhamin, Y.3
  • 59
    • 0037441593 scopus 로고    scopus 로고
    • T-cell clones can be rendered specific for CD19: Toward the selective augmentation of the graft-versus-B-lineage leukemia effect
    • Cooper LJ, Topp MS, Serrano LM, et al. T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B-lineage leukemia effect. Blood. 2003;101(4):1637-1644.
    • (2003) Blood. , vol.101 , Issue.4 , pp. 1637-1644
    • Cooper, L.J.1    Topp, M.S.2    Serrano, L.M.3
  • 60
    • 0033655529 scopus 로고    scopus 로고
    • Human T lymphocyte genetic modification with naked DNA
    • Jensen MC, Clarke P, Tan G, et al. Human T lymphocyte genetic modification with naked DNA. Mol Ther. 2000;1(1):49-55.
    • (2000) Mol Ther. , vol.1 , Issue.1 , pp. 49-55
    • Jensen, M.C.1    Clarke, P.2    Tan, G.3
  • 61
    • 22444431606 scopus 로고    scopus 로고
    • Mammalian mutagenesis using a highly mobile somatic sleeping beauty transposon system
    • Dupuy AJ, Akagi K, Largaespada DA, et al. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature. 2005;436(7048):221-226.
    • (2005) Nature. , vol.436 , Issue.7048 , pp. 221-226
    • Dupuy, A.J.1    Akagi, K.2    Largaespada, D.A.3
  • 62
    • 30444432097 scopus 로고    scopus 로고
    • Stable gene transfer and expression in human primary T-cells by the sleeping beauty transposon system
    • Huang X, Wilber AC, Bao L, et al. Stable gene transfer and expression in human primary T-cells by the Sleeping Beauty transposon system. Blood. 2006;107(2):483-491.
    • (2006) Blood. , vol.107 , Issue.2 , pp. 483-491
    • Huang, X.1    Wilber, A.C.2    Bao, L.3
  • 63
    • 80052575522 scopus 로고    scopus 로고
    • The hyperactive sleeping beauty transposase SB100X improves the genetic modification of T-cells to express a chimeric antigen receptor
    • Jin Z, Maiti S, Huls H, et al. The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T-cells to express a chimeric antigen receptor. Gene Ther. 2011;18(9):849-856.
    • (2011) Gene Ther. , vol.18 , Issue.9 , pp. 849-856
    • Jin, Z.1    Maiti, S.2    Huls, H.3
  • 64
    • 84873987094 scopus 로고    scopus 로고
    • Sleeping beauty system to redirect T-cell specificity for human applications
    • Maiti SN, Huls H, Singh H, et al. Sleeping beauty system to redirect T-cell specificity for human applications. J Immunother. 2013;36(2):112-123.
    • (2013) J Immunother. , vol.36 , Issue.2 , pp. 112-123
    • Maiti, S.N.1    Huls, H.2    Singh, H.3
  • 65
    • 42349088534 scopus 로고    scopus 로고
    • Redirecting specificity of T-cell populations for CD19 using the sleeping beauty system
    • Singh H, Manuri PR, Olivares S, et al. Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system. Cancer Res. 2008;68(8):2961-2971.
    • (2008) Cancer Res. , vol.68 , Issue.8 , pp. 2961-2971
    • Singh, H.1    Manuri, P.R.2    Olivares, S.3
  • 66
    • 77950953208 scopus 로고    scopus 로고
    • PiggyBac transposon/transposase system to generate CD19-specific T-cells for the treatment of B-lineage malignancies
    • Manuri PV, Wilson MH, Maiti SN, et al. piggyBac transposon/transposase system to generate CD19-specific T-cells for the treatment of B-lineage malignancies. Hum Gene Ther. 2010;21(4):427-437.
    • (2010) Hum Gene Ther. , vol.21 , Issue.4 , pp. 427-437
    • Manuri, P.V.1    Wilson, M.H.2    Maiti, S.N.3
  • 67
    • 70349696650 scopus 로고    scopus 로고
    • Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes
    • Nakazawa Y, Huye LE, Dotti G, et al. Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes. J Immunother. 2009;32(8):826-836.
    • (2009) J Immunother. , vol.32 , Issue.8 , pp. 826-836
    • Nakazawa, Y.1    Huye, L.E.2    Dotti, G.3
  • 68
    • 28844442400 scopus 로고    scopus 로고
    • High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation
    • Zhao Y, Zheng Z, Cohen CJ, et al. High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation. Mol Ther. 2006;13(1):151-159.
    • (2006) Mol Ther. , vol.13 , Issue.1 , pp. 151-159
    • Zhao, Y.1    Zheng, Z.2    Cohen, C.J.3
  • 69
    • 67349284360 scopus 로고    scopus 로고
    • Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T-cells for use in the adoptive immunotherapy of cancer
    • Birkholz K, Hombach A, Krug C, et al. Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T-cells for use in the adoptive immunotherapy of cancer. Gene Ther. 2009;16(5):596-604.
    • (2009) Gene Ther. , vol.16 , Issue.5 , pp. 596-604
    • Birkholz, K.1    Hombach, A.2    Krug, C.3
  • 70
    • 84942908170 scopus 로고    scopus 로고
    • Bioactivity and safety of IL13Ralpha2- redirected chimeric antigen receptor CD8+ T-cells in patients with recurrent glioblastoma
    • In press
    • Brown CE, Badie B, Barish ME, et al. Bioactivity and Safety of IL13Ralpha2- Redirected Chimeric Antigen Receptor CD8+ T-cells in Patients with Recurrent Glioblastoma. Clin Cancer Res. 2015; In press.
    • (2015) Clin Cancer Res.
    • Brown, C.E.1    Badie, B.2    Barish, M.E.3
  • 71
    • 33947265424 scopus 로고    scopus 로고
    • Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
    • Park JR, Digiusto DL, Slovak M, et al. Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Mol Ther. 2007;15(4):825-833.
    • (2007) Mol Ther. , vol.15 , Issue.4 , pp. 825-833
    • Park, J.R.1    Digiusto, D.L.2    Slovak, M.3
  • 72
    • 84867746760 scopus 로고    scopus 로고
    • Genetic modification of lymphocytes by retrovirus-based vectors
    • Suerth JD, Schambach A, Baum C. Genetic modification of lymphocytes by retrovirus-based vectors. Curr Opin Immunol. 2012;24(5):598-608.
    • (2012) Curr Opin Immunol. , vol.24 , Issue.5 , pp. 598-608
    • Suerth, J.D.1    Schambach, A.2    Baum, C.3
  • 73
    • 70349438847 scopus 로고    scopus 로고
    • Engineering lymphocyte subsets: Tools, trials and tribulations
    • June CH, Blazar BR, Riley JL. Engineering lymphocyte subsets: tools, trials and tribulations. Nat Rev Immunol. 2009;9(10):704-716.
    • (2009) Nat Rev Immunol. , vol.9 , Issue.10 , pp. 704-716
    • June, C.H.1    Blazar, B.R.2    Riley, J.L.3
  • 74
    • 69949164575 scopus 로고    scopus 로고
    • Cell-intrinsic and vectorrelated properties cooperate to determine the incidence and consequences of insertional mutagenesis
    • Kustikova OS, Schiedlmeier B, Brugman MH, et al. Cell-intrinsic and vectorrelated properties cooperate to determine the incidence and consequences of insertional mutagenesis. Mol Ther. 2009;17(9):1537-1547.
    • (2009) Mol Ther. , vol.17 , Issue.9 , pp. 1537-1547
    • Kustikova, O.S.1    Schiedlmeier, B.2    Brugman, M.H.3
  • 75
    • 84856622896 scopus 로고    scopus 로고
    • Hematopoietic stem cell engineering at a crossroads
    • Riviere I, Dunbar CE, Sadelain M. Hematopoietic stem cell engineering at a crossroads. Blood. 2012;119(5):1107-1116.
    • (2012) Blood. , vol.119 , Issue.5 , pp. 1107-1116
    • Riviere, I.1    Dunbar, C.E.2    Sadelain, M.3
  • 76
    • 55249087037 scopus 로고    scopus 로고
    • Resistance of mature T-cells to oncogene transformation
    • Newrzela S, Cornils K, Li Z, et al. Resistance of mature T-cells to oncogene transformation. Blood. 2008;112(6):2278-2286.
    • (2008) Blood. , vol.112 , Issue.6 , pp. 2278-2286
    • Newrzela, S.1    Cornils, K.2    Li, Z.3
  • 77
    • 31944440000 scopus 로고    scopus 로고
    • Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T-cells
    • Recchia A, Bonini C, Magnani Z, et al. Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T-cells. Proc Natl Acad Sci U S A. 2006;103(5):1457-1462.
    • (2006) Proc Natl Acad Sci U S A. , vol.103 , Issue.5 , pp. 1457-1462
    • Recchia, A.1    Bonini, C.2    Magnani, Z.3
  • 78
    • 77649221824 scopus 로고    scopus 로고
    • Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients
    • Heslop HE, Slobod KS, Pule MA, et al. Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients. Blood. 2010;115(5):925-935.
    • (2010) Blood. , vol.115 , Issue.5 , pp. 925-935
    • Heslop, H.E.1    Slobod, K.S.2    Pule, M.A.3
  • 79
    • 84860718270 scopus 로고    scopus 로고
    • Decade-long safety and function of retroviral-modified chimeric antigen receptor T-cells
    • Scholler J, Brady TL, Binder-Scholl G, et al. Decade-long safety and function of retroviral-modified chimeric antigen receptor T-cells. Sci Transl Med. 2012;4(132):132ra53.
    • (2012) Sci Transl Med. , vol.4 , Issue.132 , pp. 132ra53
    • Scholler, J.1    Brady, T.L.2    Binder-Scholl, G.3
  • 80
    • 80455179612 scopus 로고    scopus 로고
    • Safety and persistence of adoptively transferred autologous CD19-targeted T-cells in patients with relapsed or chemotherapy refractory B-cell leukemias
    • Brentjens RJ, Riviere I, Park JH, et al. Safety and persistence of adoptively transferred autologous CD19-targeted T-cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood. 2011;118(18):4817-4828.
    • (2011) Blood. , vol.118 , Issue.18 , pp. 4817-4828
    • Brentjens, R.J.1    Riviere, I.2    Park, J.H.3
  • 81
    • 79955517235 scopus 로고    scopus 로고
    • CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T-cells in lymphoma patients
    • Savoldo B, Ramos CA, Liu E, et al. CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T-cells in lymphoma patients. J Clin Invest. 2011;121(5):1822-1826.
    • (2011) J Clin Invest. , vol.121 , Issue.5 , pp. 1822-1826
    • Savoldo, B.1    Ramos, C.A.2    Liu, E.3
  • 82
    • 77955510549 scopus 로고    scopus 로고
    • Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/ CD19-specific chimeric antigen receptor redirected T-cells in humans
    • Jensen MC, Popplewell L, Cooper LJ, et al. Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/ CD19-specific chimeric antigen receptor redirected T-cells in humans. Biol Blood Marrow Transplant. 2010;16(9):1245-1256.
    • (2010) Biol Blood Marrow Transplant. , vol.16 , Issue.9 , pp. 1245-1256
    • Jensen, M.C.1    Popplewell, L.2    Cooper, L.J.3
  • 83
    • 68449088813 scopus 로고    scopus 로고
    • Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor
    • Kochenderfer JN, Feldman SA, Zhao Y, et al. Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor. J Immunother. 2009;32(7):689-702.
    • (2009) J Immunother. , vol.32 , Issue.7 , pp. 689-702
    • Kochenderfer, J.N.1    Feldman, S.A.2    Zhao, Y.3
  • 84
    • 84923118622 scopus 로고    scopus 로고
    • Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T-cells expressing an anti-CD19 chimeric antigen receptor
    • Kochenderfer JN, Dudley ME, Kassim SH, et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T-cells expressing an anti-CD19 chimeric antigen receptor. J Clin Oncol. 2015;33(6):540-549.
    • (2015) J Clin Oncol. , vol.33 , Issue.6 , pp. 540-549
    • Kochenderfer, J.N.1    Dudley, M.E.2    Kassim, S.H.3
  • 85
    • 84890827981 scopus 로고    scopus 로고
    • Donor-derived CD19- targeted T-cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
    • Kochenderfer JN, Dudley ME, Carpenter RO, et al. Donor-derived CD19- targeted T-cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. Blood. 2013;122(25):4129-4139.
    • (2013) Blood. , vol.122 , Issue.25 , pp. 4129-4139
    • Kochenderfer, J.N.1    Dudley, M.E.2    Carpenter, R.O.3
  • 86
    • 84887821770 scopus 로고    scopus 로고
    • Infusion of donor-derived CD19- redirected virus-specific T-cells for B-cell malignancies relapsed after allogeneic stem cell transplant: A phase 1 study
    • Cruz CR, Micklethwaite KP, Savoldo B, et al. Infusion of donor-derived CD19- redirected virus-specific T-cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study. Blood. 2013;122(17):2965-2973.
    • (2013) Blood. , vol.122 , Issue.17 , pp. 2965-2973
    • Cruz, C.R.1    Micklethwaite, K.P.2    Savoldo, B.3
  • 87
    • 55949125601 scopus 로고    scopus 로고
    • Adoptive cell therapy for patients with metastatic melanoma: Evaluation of intensive myeloablative chemoradiation preparative regimens
    • Dudley ME, Yang JC, Sherry R, et al. Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J Clin Oncol. 2008;26(32):5233-5239.
    • (2008) J Clin Oncol. , vol.26 , Issue.32 , pp. 5233-5239
    • Dudley, M.E.1    Yang, J.C.2    Sherry, R.3
  • 88
    • 33746102229 scopus 로고    scopus 로고
    • Comparison of common gamma-chain cytokines, interleukin-2, interleukin-7, and interleukin-15 for the in vitro generation of human tumor-reactive T lymphocytes for adoptive cell transfer therapy
    • Liu S, Riley J, Rosenberg S, et al. Comparison of common gamma-chain cytokines, interleukin-2, interleukin-7, and interleukin-15 for the in vitro generation of human tumor-reactive T lymphocytes for adoptive cell transfer therapy. J Immunother. 2006;29(3):284-293.
    • (2006) J Immunother. , vol.29 , Issue.3 , pp. 284-293
    • Liu, S.1    Riley, J.2    Rosenberg, S.3
  • 89
    • 67649876115 scopus 로고    scopus 로고
    • New insights into the regulation of T-cells by gamma(c) family cytokines
    • Rochman Y, Spolski R, Leonard WJ. New insights into the regulation of T-cells by gamma(c) family cytokines. Nat Rev Immunol. 2009;9(7):480-490.
    • (2009) Nat Rev Immunol. , vol.9 , Issue.7 , pp. 480-490
    • Rochman, Y.1    Spolski, R.2    Leonard, W.J.3
  • 90
    • 84902590274 scopus 로고    scopus 로고
    • Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T-cells and are preserved by IL-7 and IL-15
    • Xu Y, Zhang M, Ramos CA, et al. Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T-cells and are preserved by IL-7 and IL-15. Blood. 2014;123(24):3750-3759.
    • (2014) Blood. , vol.123 , Issue.24 , pp. 3750-3759
    • Xu, Y.1    Zhang, M.2    Ramos, C.A.3
  • 91
    • 84877666359 scopus 로고    scopus 로고
    • How do CARs work': Early insights from recent clinical studies targeting CD19
    • Davila ML, Brentjens R, Wang X, et al. How do CARs work': Early insights from recent clinical studies targeting CD19. Oncoimmunology. 2012;1(9):1577-1583.
    • (2012) Oncoimmunology. , vol.1 , Issue.9 , pp. 1577-1583
    • Davila, M.L.1    Brentjens, R.2    Wang, X.3
  • 92
    • 84899631361 scopus 로고    scopus 로고
    • Antibody-modified T-cells: CARs take the front seat for hematologic malignancies
    • Maus MV, Grupp SA, Porter DL, et al. Antibody-modified T-cells: CARs take the front seat for hematologic malignancies. Blood. 2014;123(17):2625-2635.
    • (2014) Blood. , vol.123 , Issue.17 , pp. 2625-2635
    • Maus, M.V.1    Grupp, S.A.2    Porter, D.L.3
  • 93
    • 0030483542 scopus 로고    scopus 로고
    • Identification of the earliest B lineage stage in mouse bone marrow
    • Li YS, Wasserman R, Hayakawa K, et al. Identification of the earliest B lineage stage in mouse bone marrow. Immunity. 1996;5(6):527-535.
    • (1996) Immunity. , vol.5 , Issue.6 , pp. 527-535
    • Li, Y.S.1    Wasserman, R.2    Hayakawa, K.3
  • 94
    • 0027275497 scopus 로고
    • The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
    • Li YS, Hayakawa K, Hardy RR. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med. 1993;178(3):951-960.
    • (1993) J Exp Med. , vol.178 , Issue.3 , pp. 951-960
    • Li, Y.S.1    Hayakawa, K.2    Hardy, R.R.3
  • 95
    • 34848842554 scopus 로고    scopus 로고
    • Genetically targeted T-cells eradicate systemic acute lymphoblastic leukemia xenografts
    • Brentjens RJ, Santos E, Nikhamin Y, et al. Genetically targeted T-cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin Cancer Res. 2007;13(18 Pt 1):5426-5435.
    • (2007) Clin Cancer Res. , vol.13 , Issue.18 , pp. 5426-5435
    • Brentjens, R.J.1    Santos, E.2    Nikhamin, Y.3
  • 96
    • 84933510694 scopus 로고    scopus 로고
    • CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia
    • Maude SL, Teachey DT, Porter DL, et al. CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Blood. 2015;125(26):4017-4023.
    • (2015) Blood. , vol.125 , Issue.26 , pp. 4017-4023
    • Maude, S.L.1    Teachey, D.T.2    Porter, D.L.3
  • 97
    • 84863337890 scopus 로고    scopus 로고
    • B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T-cells
    • Kochenderfer JN, Dudley ME, Feldman SA, et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T-cells. Blood. 2012;119(12):2709-2720.
    • (2012) Blood. , vol.119 , Issue.12 , pp. 2709-2720
    • Kochenderfer, J.N.1    Dudley, M.E.2    Feldman, S.A.3
  • 98
    • 84896335556 scopus 로고    scopus 로고
    • Efficacy and toxicity management of 19-28z CAR T-cell therapy in B cell acute lymphoblastic leukemia
    • Davila ML, Riviere I, Wang X, et al. Efficacy and toxicity management of 19-28z CAR T-cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med. 2014;6(224):224ra25.
    • (2014) Sci Transl Med. , vol.6 , Issue.224 , pp. 224ra25
    • Davila, M.L.1    Riviere, I.2    Wang, X.3
  • 99
    • 84941758827 scopus 로고    scopus 로고
    • Tolerance and efficacy of autologous or donorderived T-cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia
    • Dai H, Zhang W, Li X, et al. Tolerance and efficacy of autologous or donorderived T-cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia. OncoImmunology. 2015;4(11):e1027469.
    • (2015) OncoImmunology. , vol.4 , Issue.11 , pp. e1027469
    • Dai, H.1    Zhang, W.2    Li, X.3
  • 100
    • 84908299844 scopus 로고    scopus 로고
    • Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T-cells
    • Wang Y, Zhang WY, Han QW, et al. Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T-cells. Clin Immunol. 2014;155(2):160-175.
    • (2014) Clin Immunol. , vol.155 , Issue.2 , pp. 160-175
    • Wang, Y.1    Zhang, W.Y.2    Han, Q.W.3
  • 101
    • 84860333968 scopus 로고    scopus 로고
    • CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: Pilot clinical trial results
    • Till BG, Jensen MC, Wang J, et al. CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results. Blood. 2012;119(17):3940-3950.
    • (2012) Blood. , vol.119 , Issue.17 , pp. 3940-3950
    • Till, B.G.1    Jensen, M.C.2    Wang, J.3
  • 102
    • 84887419384 scopus 로고    scopus 로고
    • Persistence and efficacy of second generation CAR T-cell against the LeY antigen in acute myeloid leukemia
    • Ritchie DS, Neeson PJ, Khot A, et al. Persistence and efficacy of second generation CAR T-cell against the LeY antigen in acute myeloid leukemia. Mol Ther. 2013;21(11):2122-2129.
    • (2013) Mol Ther. , vol.21 , Issue.11 , pp. 2122-2129
    • Ritchie, D.S.1    Neeson, P.J.2    Khot, A.3
  • 103
    • 84920693049 scopus 로고    scopus 로고
    • Treatment of CD33-directed chimeric antigen receptor-modified T-cells in one patient with relapsed and refractory acute myeloid leukemia
    • Wang QS, Wang Y, Lv HY, et al. Treatment of CD33-directed chimeric antigen receptor-modified T-cells in one patient with relapsed and refractory acute myeloid leukemia. Mol Ther. 2015;23(1):184-191.
    • (2015) Mol Ther. , vol.23 , Issue.1 , pp. 184-191
    • Wang, Q.S.1    Wang, Y.2    Lv, H.Y.3
  • 104
    • 84941312389 scopus 로고    scopus 로고
    • Chimeric antigen receptor T-cells against CD19 for multiple myeloma
    • Garfall AL, Maus MV, Hwang WT, et al. Chimeric Antigen Receptor T-cells against CD19 for Multiple Myeloma. N Engl J Med. 2015;373(11):1040-1047.
    • (2015) N Engl J Med. , vol.373 , Issue.11 , pp. 1040-1047
    • Garfall, A.L.1    Maus, M.V.2    Hwang, W.T.3
  • 105
    • 84933178008 scopus 로고    scopus 로고
    • Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T
    • Burga RA, Thorn M, Point GR, et al. Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T. Cancer Immunol Immunother. 2015;64(7):817-829.
    • (2015) Cancer Immunol Immunother. , vol.64 , Issue.7 , pp. 817-829
    • Burga, R.A.1    Thorn, M.2    Point, G.R.3
  • 106
    • 84942910678 scopus 로고    scopus 로고
    • Phase i hepatic immunotherapy for metastases study of intra-arterial chimeric antigen receptor-modified t-cell therapy for CEA+ liver metastases
    • Katz SC, Burga RA, McCormack E, et al. Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor-Modified T-cell Therapy for CEA+ Liver Metastases. Clin Cancer Res. 2015;21(14):3149-3159.
    • (2015) Clin Cancer Res. , vol.21 , Issue.14 , pp. 3149-3159
    • Katz, S.C.1    Burga, R.A.2    McCormack, E.3
  • 107
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T-cells transduced with a chimeric antigen receptor recognizing ERBB2
    • Morgan RA, Yang JC, Kitano M, et al. Case report of a serious adverse event following the administration of T-cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther. 2010;18(4):843-851.
    • (2010) Mol Ther. , vol.18 , Issue.4 , pp. 843-851
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3
  • 108
    • 84878605813 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T-cells: Clinical evaluation and management of on-target toxicity
    • Lamers CH, Sleijfer S, van Steenbergen S, et al. Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T-cells: clinical evaluation and management of on-target toxicity. Mol Ther. 2013;21(4):904-912.
    • (2013) Mol Ther. , vol.21 , Issue.4 , pp. 904-912
    • Lamers, C.H.1    Sleijfer, S.2    Van Steenbergen, S.3
  • 109
    • 34848818523 scopus 로고    scopus 로고
    • Gene-modified T-cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo
    • Lamers CH, Langeveld SC, Groot-van Ruijven CM, et al. Gene-modified T-cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo. Cancer Immunol Immunother. 2007;56(12):1875-1883.
    • (2007) Cancer Immunol Immunother. , vol.56 , Issue.12 , pp. 1875-1883
    • Lamers, C.H.1    Langeveld, S.C.2    Groot-Van Ruijven, C.M.3
  • 110
    • 33646440024 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: First clinical experience
    • Lamers CH, Sleijfer S, Vulto AG, et al. Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol. 2006;24(13):e20-e22.
    • (2006) J Clin Oncol. , vol.24 , Issue.13 , pp. e20-e22
    • Lamers, C.H.1    Sleijfer, S.2    Vulto, A.G.3
  • 111
    • 33750699642 scopus 로고    scopus 로고
    • A phase i study on adoptive immunotherapy using gene-modified T-cells for ovarian cancer
    • Kershaw MH, Westwood JA, Parker LL, et al. A phase I study on adoptive immunotherapy using gene-modified T-cells for ovarian cancer. Clin Cancer Res. 2006;12(20 Pt 1):6106-6115.
    • (2006) Clin Cancer Res. , vol.12 , Issue.20 , pp. 6106-6115
    • Kershaw, M.H.1    Westwood, J.A.2    Parker, L.L.3
  • 112
    • 84874286123 scopus 로고    scopus 로고
    • CARs in chronic lymphocytic leukemia - ready to drive
    • Hosing C, Kebriaei P, Wierda W, et al. CARs in chronic lymphocytic leukemia - ready to drive. Curr Hematol Malig Rep. 2013;8(1):60-70.
    • (2013) Curr Hematol Malig Rep. , vol.8 , Issue.1 , pp. 60-70
    • Hosing, C.1    Kebriaei, P.2    Wierda, W.3
  • 113
    • 84879384673 scopus 로고    scopus 로고
    • Novel cellular therapies for leukemia: CAR-modified T-cells targeted to the CD19 antigen
    • Brentjens RJ, Curran KJ. Novel cellular therapies for leukemia: CAR-modified T-cells targeted to the CD19 antigen. Hematology Am Soc Hematol Educ Program. 2012;2012:143-151.
    • (2012) Hematology Am Soc Hematol Educ Program. , vol.2012 , pp. 143-151
    • Brentjens, R.J.1    Curran, K.J.2
  • 114
    • 84897568616 scopus 로고    scopus 로고
    • Managing cytokine release syndrome associated with novel T-cell-engaging therapies
    • Maude SL, Barrett D, Teachey DT, et al. Managing cytokine release syndrome associated with novel T-cell-engaging therapies. Cancer J. 2014;20(2):119-122.
    • (2014) Cancer J. , vol.20 , Issue.2 , pp. 119-122
    • Maude, S.L.1    Barrett, D.2    Teachey, D.T.3
  • 115
    • 78549253550 scopus 로고    scopus 로고
    • Multiple injections of electroporated autologous T-cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor
    • Zhao Y, Moon E, Carpenito C, et al. Multiple injections of electroporated autologous T-cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor. Cancer Res. 2010;70(22):9053-9061.
    • (2010) Cancer Res. , vol.70 , Issue.22 , pp. 9053-9061
    • Zhao, Y.1    Moon, E.2    Carpenito, C.3
  • 116
    • 65349157330 scopus 로고    scopus 로고
    • Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): A non-randomised phase I-II study
    • Ciceri F, Bonini C, Stanghellini MT, et al. Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study. Lancet Oncol. 2009;10(5):489-500.
    • (2009) Lancet Oncol. , vol.10 , Issue.5 , pp. 489-500
    • Ciceri, F.1    Bonini, C.2    Stanghellini, M.T.3
  • 117
    • 80455162464 scopus 로고    scopus 로고
    • Inducible apoptosis as a safety switch for adoptive cell therapy
    • Di Stasi A, Tey SK, Dotti G, et al. Inducible apoptosis as a safety switch for adoptive cell therapy. N Engl J Med. 2011;365(18):1673-1683.
    • (2011) N Engl J Med. , vol.365 , Issue.18 , pp. 1673-1683
    • Di Stasi, A.1    Tey, S.K.2    Dotti, G.3
  • 118
    • 84890207337 scopus 로고    scopus 로고
    • T-cells expressing chimeric antigen receptors can cause anaphylaxis in humans
    • Maus MV, Haas AR, Beatty GL, et al. T-cells expressing chimeric antigen receptors can cause anaphylaxis in humans. Cancer Immunol Res. 2013;1:26-31.
    • (2013) Cancer Immunol Res. , vol.1 , pp. 26-31
    • Maus, M.V.1    Haas, A.R.2    Beatty, G.L.3
  • 119
    • 0037441766 scopus 로고    scopus 로고
    • Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation
    • Marktel S, Magnani Z, Ciceri F, et al. Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation. Blood. 2003;101(4):1290-1298.
    • (2003) Blood. , vol.101 , Issue.4 , pp. 1290-1298
    • Marktel, S.1    Magnani, Z.2    Ciceri, F.3
  • 120
    • 33644750264 scopus 로고    scopus 로고
    • Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T-cells after allogeneic hematopoietic cell transplantation
    • Berger C, Flowers ME, Warren EH, et al. Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T-cells after allogeneic hematopoietic cell transplantation. Blood. 2006;107(6):2294-2302.
    • (2006) Blood. , vol.107 , Issue.6 , pp. 2294-2302
    • Berger, C.1    Flowers, M.E.2    Warren, E.H.3
  • 121
    • 34249748406 scopus 로고    scopus 로고
    • The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies
    • Traversari C, Marktel S, Magnani Z, et al. The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies. Blood. 2007;109(11):4708-4715.
    • (2007) Blood. , vol.109 , Issue.11 , pp. 4708-4715
    • Traversari, C.1    Marktel, S.2    Magnani, Z.3
  • 122
    • 84940742884 scopus 로고    scopus 로고
    • A fully human chimeric antigen receptor with potent activity against cancer cells but reduced risk for off-tumor toxicity
    • Song DG, Ye Q, Poussin M, et al. A fully human chimeric antigen receptor with potent activity against cancer cells but reduced risk for off-tumor toxicity. Oncotarget. 2015;6(25):21533-21546.
    • (2015) Oncotarget. , vol.6 , Issue.25 , pp. 21533-21546
    • Song, D.G.1    Ye, Q.2    Poussin, M.3
  • 123
    • 80051589534 scopus 로고    scopus 로고
    • A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells
    • Wang X, Chang WC, Wong CW, et al. A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells. Blood. 2011;118(5):1255-1263.
    • (2011) Blood. , vol.118 , Issue.5 , pp. 1255-1263
    • Wang, X.1    Chang, W.C.2    Wong, C.W.3
  • 124
    • 84872196489 scopus 로고    scopus 로고
    • Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T-cells
    • Kloss CC, Condomines M, Cartellieri M, et al. Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T-cells. Nat Biotechnol. 2013;31(1):71-75.
    • (2013) Nat Biotechnol. , vol.31 , Issue.1 , pp. 71-75
    • Kloss, C.C.1    Condomines, M.2    Cartellieri, M.3
  • 125
    • 84891708419 scopus 로고    scopus 로고
    • PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses
    • Fedorov VD, Themeli M, Sadelain M. PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses. Sci Transl Med. 2013;5(215):215ra172.
    • (2013) Sci Transl Med. , vol.5 , Issue.215 , pp. 215ra172
    • Fedorov, V.D.1    Themeli, M.2    Sadelain, M.3
  • 126
    • 84942907010 scopus 로고    scopus 로고
    • Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent antitumor activity
    • Caruso HG, Hurton LV, Najjar A, et al. Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity. Cancer Res. 2015;75(17):3505-3518.
    • (2015) Cancer Res. , vol.75 , Issue.17 , pp. 3505-3518
    • Caruso, H.G.1    Hurton, L.V.2    Najjar, A.3
  • 127
    • 84942885584 scopus 로고    scopus 로고
    • Affinity-tuned ErbB2 or EGFR chimeric antigen receptor t-cells exhibit an increased therapeutic index against tumors in mice
    • Liu X, Jiang S, Fang C, et al. Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T-cells Exhibit an Increased Therapeutic Index against Tumors in Mice. Cancer Res. 2015;75(17):3596-3607.
    • (2015) Cancer Res. , vol.75 , Issue.17 , pp. 3596-3607
    • Liu, X.1    Jiang, S.2    Fang, C.3
  • 128
    • 67650638846 scopus 로고    scopus 로고
    • T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model
    • Di Stasi A, De Angelis B, Rooney CM, et al. T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model. Blood. 2009;113(25):6392-6402.
    • (2009) Blood. , vol.113 , Issue.25 , pp. 6392-6402
    • Di Stasi, A.1    De Angelis, B.2    Rooney, C.M.3
  • 129
    • 84863680262 scopus 로고    scopus 로고
    • Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease
    • Reshef R, Luger SM, Hexner EO, et al. Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease. N Engl J Med. 2012;367(2):135-145.
    • (2012) N Engl J Med. , vol.367 , Issue.2 , pp. 135-145
    • Reshef, R.1    Luger, S.M.2    Hexner, E.O.3
  • 130
    • 84880730689 scopus 로고    scopus 로고
    • Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T-cells in myeloma and melanoma
    • Linette GP, Stadtmauer EA, Maus MV, et al. Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T-cells in myeloma and melanoma. Blood. 2013;122(6):863-871.
    • (2013) Blood. , vol.122 , Issue.6 , pp. 863-871
    • Linette, G.P.1    Stadtmauer, E.A.2    Maus, M.V.3
  • 131
    • 84883866836 scopus 로고    scopus 로고
    • Identification of a titin-derived HLAA1- presented peptide as a cross-reactive target for engineered MAGE A3-directed T-cells
    • Cameron BJ, Gerry AB, Dukes J, et al. Identification of a Titin-derived HLAA1- presented peptide as a cross-reactive target for engineered MAGE A3-directed T-cells. Sci Transl Med. 2013;5(197):197ra103.
    • (2013) Sci Transl Med. , vol.5 , Issue.197 , pp. 197ra103
    • Cameron, B.J.1    Gerry, A.B.2    Dukes, J.3
  • 132
    • 77958063691 scopus 로고    scopus 로고
    • Enhanced tumor trafficking of GD2 chimeric antigen receptor T-cells by expression of the chemokine receptor CCR2b
    • Craddock JA, Lu A, Bear A, et al. Enhanced tumor trafficking of GD2 chimeric antigen receptor T-cells by expression of the chemokine receptor CCR2b. J Immunother. 2010;33(8):780-788.
    • (2010) J Immunother. , vol.33 , Issue.8 , pp. 780-788
    • Craddock, J.A.1    Lu, A.2    Bear, A.3
  • 133
    • 84863230570 scopus 로고    scopus 로고
    • Local delivery of interleukin-12 using T-cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice
    • Chinnasamy D, Yu Z, Kerkar SP, et al. Local delivery of interleukin-12 using T-cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice. Clin Cancer Res. 2012;18(6):1672-1683.
    • (2012) Clin Cancer Res. , vol.18 , Issue.6 , pp. 1672-1683
    • Chinnasamy, D.1    Yu, Z.2    Kerkar, S.P.3
  • 134
    • 84937758074 scopus 로고    scopus 로고
    • Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
    • Caruana I, Savoldo B, Hoyos V, et al. Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes. Nat Med. 2015;21(5):524-529.
    • (2015) Nat Med. , vol.21 , Issue.5 , pp. 524-529
    • Caruana, I.1    Savoldo, B.2    Hoyos, V.3
  • 135
    • 38049000452 scopus 로고    scopus 로고
    • Endothelin B receptor mediates the endothelial barrier to T-cell homing to tumors and disables immune therapy
    • Buckanovich RJ, Facciabene A, Kim S, et al. Endothelin B receptor mediates the endothelial barrier to T-cell homing to tumors and disables immune therapy. Nat Med. 2008;14(1):28-36.
    • (2008) Nat Med. , vol.14 , Issue.1 , pp. 28-36
    • Buckanovich, R.J.1    Facciabene, A.2    Kim, S.3
  • 136
    • 0036494443 scopus 로고    scopus 로고
    • Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication
    • Ganss R, Ryschich E, Klar E, et al. Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication. Cancer Res. 2002;62(5):1462-1470.
    • (2002) Cancer Res. , vol.62 , Issue.5 , pp. 1462-1470
    • Ganss, R.1    Ryschich, E.2    Klar, E.3
  • 137
    • 84862490985 scopus 로고    scopus 로고
    • Levels of peripheral CD4(+)FoxP3(+) regulatory T-cells are negatively associated with clinical response to adoptive immunotherapy of human cancer
    • Yao X, Ahmadzadeh M, Lu YC, et al. Levels of peripheral CD4(+)FoxP3(+) regulatory T-cells are negatively associated with clinical response to adoptive immunotherapy of human cancer. Blood. 2012;119(24):5688-5696.
    • (2012) Blood. , vol.119 , Issue.24 , pp. 5688-5696
    • Yao, X.1    Ahmadzadeh, M.2    Lu, Y.C.3
  • 138
    • 25844484607 scopus 로고    scopus 로고
    • Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T-cells
    • Gattinoni L, Finkelstein SE, Klebanoff CA, et al. Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T-cells. J Exp Med. 2005;202(7):907-912.
    • (2005) J Exp Med. , vol.202 , Issue.7 , pp. 907-912
    • Gattinoni, L.1    Finkelstein, S.E.2    Klebanoff, C.A.3
  • 139
    • 38149117105 scopus 로고    scopus 로고
    • Adoptive transfer of effector CD8+ T-cells derived from central memory cells establishes persistent T-cell memory in primates
    • Berger C, Jensen MC, Lansdorp PM, et al. Adoptive transfer of effector CD8+ T-cells derived from central memory cells establishes persistent T-cell memory in primates. J Clin Invest. 2008;118(1):294-305.
    • (2008) J Clin Invest. , vol.118 , Issue.1 , pp. 294-305
    • Berger, C.1    Jensen, M.C.2    Lansdorp, P.M.3
  • 140
    • 70350458112 scopus 로고    scopus 로고
    • Adoptively transferred effector cells derived from naive rather than central memory CD8+ T-cells mediate superior antitumor immunity
    • Hinrichs CS, Borman ZA, Cassard L, et al. Adoptively transferred effector cells derived from naive rather than central memory CD8+ T-cells mediate superior antitumor immunity. Proc Natl Acad Sci U S A. 2009;106(41):17469-17474.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , Issue.41 , pp. 17469-17474
    • Hinrichs, C.S.1    Borman, Z.A.2    Cassard, L.3
  • 141
    • 84868221578 scopus 로고    scopus 로고
    • Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T-cells manufactured at clinical scale
    • Wang X, Naranjo A, Brown CE, et al. Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T-cells manufactured at clinical scale. J Immunother. 2012;35(9):689-701.
    • (2012) J Immunother. , vol.35 , Issue.9 , pp. 689-701
    • Wang, X.1    Naranjo, A.2    Brown, C.E.3
  • 142
    • 84904394259 scopus 로고    scopus 로고
    • Serial transfer of single-cellderived immunocompetence reveals stemness of CD8(+) central memory T-cells
    • Graef P, Buchholz VR, Stemberger C, et al. Serial transfer of single-cellderived immunocompetence reveals stemness of CD8(+) central memory T-cells. Immunity. 2014;41(1):116-126.
    • (2014) Immunity. , vol.41 , Issue.1 , pp. 116-126
    • Graef, P.1    Buchholz, V.R.2    Stemberger, C.3
  • 143
    • 67650465237 scopus 로고    scopus 로고
    • Wnt signaling arrests effector T-cell differentiation and generates CD8+ memory stem cells
    • Gattinoni L, Zhong XS, Palmer DC, et al. Wnt signaling arrests effector T-cell differentiation and generates CD8+ memory stem cells. Nat Med. 2009;15(7):808-813.
    • (2009) Nat Med. , vol.15 , Issue.7 , pp. 808-813
    • Gattinoni, L.1    Zhong, X.S.2    Palmer, D.C.3
  • 144
    • 84922544653 scopus 로고    scopus 로고
    • IL-12-secreting CD19-targeted cord blood-derived T-cells for the immunotherapy of B-cell acute lymphoblastic leukemia
    • Pegram HJ, Purdon TJ, van Leeuwen DG, et al. IL-12-secreting CD19-targeted cord blood-derived T-cells for the immunotherapy of B-cell acute lymphoblastic leukemia. Leukemia. 2015;29(2):415-422.
    • (2015) Leukemia. , vol.29 , Issue.2 , pp. 415-422
    • Pegram, H.J.1    Purdon, T.J.2    Van Leeuwen, D.G.3
  • 145
    • 84872790689 scopus 로고    scopus 로고
    • Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy
    • Liao W, Lin JX, Leonard WJ. Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity. 2013;38(1):13-25.
    • (2013) Immunity. , vol.38 , Issue.1 , pp. 13-25
    • Liao, W.1    Lin, J.X.2    Leonard, W.J.3
  • 146
    • 84862496486 scopus 로고    scopus 로고
    • A foundation for universal T-cell based immunotherapy: T-cells engineered to express a CD19-specific chimericantigen- receptor and eliminate expression of endogenous TCR
    • Torikai H, Reik A, Liu PQ, et al. A foundation for universal T-cell based immunotherapy: T-cells engineered to express a CD19-specific chimericantigen- receptor and eliminate expression of endogenous TCR. Blood. 2012;119(24):5697-5705.
    • (2012) Blood. , vol.119 , Issue.24 , pp. 5697-5705
    • Torikai, H.1    Reik, A.2    Liu, P.Q.3
  • 147
    • 84942903938 scopus 로고    scopus 로고
    • Multiplex genome-edited t-cell manufacturing platform for "off-The-shelf" adoptive t-cell immunotherapies
    • Poirot L, Philip B, Schiffer-Mannioui C, et al. Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies. Cancer Res. 2015;75(18):3853-3864.
    • (2015) Cancer Res. , vol.75 , Issue.18 , pp. 3853-3864
    • Poirot, L.1    Philip, B.2    Schiffer-Mannioui, C.3
  • 148
    • 55249117972 scopus 로고    scopus 로고
    • Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor
    • Foster AE, Dotti G, Lu A, et al. Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor. J Immunother. 2008;31(5):500-505.
    • (2008) J Immunother. , vol.31 , Issue.5 , pp. 500-505
    • Foster, A.E.1    Dotti, G.2    Lu, A.3
  • 149
    • 79952755728 scopus 로고    scopus 로고
    • Cancer immunotherapy using a bispecific NK receptor fusion protein that engages both T-cells and tumor cells
    • Zhang T, Sentman CL. Cancer immunotherapy using a bispecific NK receptor fusion protein that engages both T-cells and tumor cells. Cancer Res. 2011;71(6):2066-2076.
    • (2011) Cancer Res. , vol.71 , Issue.6 , pp. 2066-2076
    • Zhang, T.1    Sentman, C.L.2
  • 150
    • 84874285199 scopus 로고    scopus 로고
    • Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T-cells
    • Zhang T, Sentman CL. Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T-cells. J Immunol. 2013;190(5):2455-2463.
    • (2013) J Immunol. , vol.190 , Issue.5 , pp. 2455-2463
    • Zhang, T.1    Sentman, C.L.2
  • 151
    • 73349123470 scopus 로고    scopus 로고
    • Chimeric NKG2D expressing T-cells eliminate immunosuppression and activate immunity within the ovarian tumor microenvironment
    • Barber A, Rynda A, Sentman CL. Chimeric NKG2D expressing T-cells eliminate immunosuppression and activate immunity within the ovarian tumor microenvironment. J Immunol. 2009;183(11):6939-6947.
    • (2009) J Immunol. , vol.183 , Issue.11 , pp. 6939-6947
    • Barber, A.1    Rynda, A.2    Sentman, C.L.3
  • 152
    • 84938368102 scopus 로고    scopus 로고
    • Tumor-targeted human t-cells expressing CD28-based chimeric antigen receptors circumvent CTLA-4 inhibition
    • Condomines M, Arnason J, Benjamin R, et al. Tumor-Targeted Human T-cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition. PLoS One. 2015;10(6):e0130518.
    • (2015) PLoS One. , vol.10 , Issue.6 , pp. e0130518
    • Condomines, M.1    Arnason, J.2    Benjamin, R.3
  • 153
    • 20444425695 scopus 로고    scopus 로고
    • Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis
    • Dotti G, Savoldo B, Pule M, et al. Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis. Blood. 2005;105(12):4677-4684.
    • (2005) Blood. , vol.105 , Issue.12 , pp. 4677-4684
    • Dotti, G.1    Savoldo, B.2    Pule, M.3
  • 154
    • 85047696817 scopus 로고    scopus 로고
    • Retroviral transduction of human peripheral blood lymphocytes with Bcl-X(L) promotes in vitro lymphocyte survival in pro-apoptotic conditions
    • Eaton D, Gilham DE, O'Neill A, et al. Retroviral transduction of human peripheral blood lymphocytes with Bcl-X(L) promotes in vitro lymphocyte survival in pro-apoptotic conditions. Gene Ther. 2002;9(8):527-535.
    • (2002) Gene Ther. , vol.9 , Issue.8 , pp. 527-535
    • Eaton, D.1    Gilham, D.E.2    O'Neill, A.3
  • 155
    • 84938983902 scopus 로고    scopus 로고
    • Identification and selective expansion of functionally superior T-cells expressing chimeric antigen receptors
    • Chang ZL, Silver PA, Chen YY. Identification and selective expansion of functionally superior T-cells expressing chimeric antigen receptors. J Transl Med. 2015;13:161.
    • (2015) J Transl Med. , vol.13 , pp. 161
    • Chang, Z.L.1    Silver, P.A.2    Chen, Y.Y.3
  • 156
    • 84904609350 scopus 로고    scopus 로고
    • Blockade of PD-1 immunosuppression boosts CAR T-cell therapy
    • John LB, Kershaw MH, Darcy PK. Blockade of PD-1 immunosuppression boosts CAR T-cell therapy. Oncoimmunology. 2013;2(10):e26286.
    • (2013) Oncoimmunology. , vol.2 , Issue.10 , pp. e26286
    • John, L.B.1    Kershaw, M.H.2    Darcy, P.K.3
  • 157
    • 84886397930 scopus 로고    scopus 로고
    • Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T-cells
    • John LB, Devaud C, Duong CP, et al. Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T-cells. Clin Cancer Res. 2013;19(20):5636-5646.
    • (2013) Clin Cancer Res. , vol.19 , Issue.20 , pp. 5636-5646
    • John, L.B.1    Devaud, C.2    Duong, C.P.3
  • 158
    • 84861224393 scopus 로고    scopus 로고
    • Tumor PD-L1 co-stimulates primary human CD8(+) cytotoxic T-cells modified to express a PD1:CD28 chimeric receptor
    • Prosser ME, Brown CE, Shami AF, et al. Tumor PD-L1 co-stimulates primary human CD8(+) cytotoxic T-cells modified to express a PD1:CD28 chimeric receptor. Mol Immunol. 2012;51(3-4):263-272.
    • (2012) Mol Immunol. , vol.51 , Issue.3-4 , pp. 263-272
    • Prosser, M.E.1    Brown, C.E.2    Shami, A.F.3
  • 159
    • 84935012050 scopus 로고    scopus 로고
    • Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T-cells and is downregulated by lymphodepleting drugs
    • Ninomiya S, Narala N, Huye L, et al. Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T-cells and is downregulated by lymphodepleting drugs. Blood. 2015;125(25):3905-3916.
    • (2015) Blood. , vol.125 , Issue.25 , pp. 3905-3916
    • Ninomiya, S.1    Narala, N.2    Huye, L.3
  • 160
    • 84890214448 scopus 로고    scopus 로고
    • CAR T-cells: Driving the road from the laboratory to the clinic
    • Cheadle EJ, Gornall H, Baldan V, et al. CAR T-cells: driving the road from the laboratory to the clinic. Immunol Rev. 2014;257(1):91-106.
    • (2014) Immunol Rev. , vol.257 , Issue.1 , pp. 91-106
    • Cheadle, E.J.1    Gornall, H.2    Baldan, V.3
  • 161
    • 50549096284 scopus 로고    scopus 로고
    • Adoptive immunotherapy for indolent non-hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T-cells
    • Till BG, Jensen MC, Wang J, et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T-cells. Blood. 2008;112(6):2261-2271.
    • (2008) Blood. , vol.112 , Issue.6 , pp. 2261-2271
    • Till, B.G.1    Jensen, M.C.2    Wang, J.3
  • 162
    • 78549278144 scopus 로고    scopus 로고
    • Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T-cells genetically engineered to recognize CD19
    • Kochenderfer JN, Wilson WH, Janik JE, et al. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T-cells genetically engineered to recognize CD19. Blood. 2010;116(20):4099-4102.
    • (2010) Blood. , vol.116 , Issue.20 , pp. 4099-4102
    • Kochenderfer, J.N.1    Wilson, W.H.2    Janik, J.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.