메뉴 건너뛰기




Volumn 10, Issue 1, 2017, Pages

New development in CAR-T cell therapy

Author keywords

Adoptive cell therapy; Cancer treatment; CAR T; Chimeric antigen receptor; Engineered T cells

Indexed keywords

CD123 ANTIGEN; CD19 ANTIGEN; CHIMERIC ANTIGEN RECEPTOR; CYCLOPHOSPHAMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ETOPOSIDE; FLUDARABINE; MUCIN 1; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 85014216230     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-017-0423-1     Document Type: Review
Times cited : (305)

References (94)
  • 1
    • 38449095735 scopus 로고    scopus 로고
    • The T-body approach: Redirecting T cells with antibody specificity
    • 1:CAS:528:DC%2BD1cXhslSjtbo%3D
    • Eshhar Z. The T-body approach: redirecting T cells with antibody specificity. Handb Exp Pharmacol. 2008;181:329-42.
    • (2008) Handb Exp Pharmacol , vol.181 , pp. 329-342
    • Eshhar, Z.1
  • 2
    • 84862838257 scopus 로고    scopus 로고
    • Chimeric antigen receptors for T cell immunotherapy: Current understanding and future directions
    • 1:CAS:528:DC%2BC38XptFCitL4%3D 22262649 4697438
    • Curran KJ, Pegram HJ, Brentjens RJ. Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions. J Gene Med. 2012;14(6):405-15.
    • (2012) J Gene Med , vol.14 , Issue.6 , pp. 405-415
    • Curran, K.J.1    Pegram, H.J.2    Brentjens, R.J.3
  • 3
    • 84979268324 scopus 로고    scopus 로고
    • Chimeric antigen receptors modified T-cells for cancer therapy
    • Dai H, Wang Y, Lu X, Han W. Chimeric antigen receptors modified T-cells for cancer therapy. J Natl Cancer Inst. 2016;108(7):djv439.
    • (2016) J Natl Cancer Inst , vol.108 , Issue.7 , pp. djv439
    • Dai, H.1    Wang, Y.2    Lu, X.3    Han, W.4
  • 4
    • 0027471898 scopus 로고
    • Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
    • 1:CAS:528:DyaK3sXitVCkurY%3D 8421711 45737
    • Eshhar Z, Waks T, Gross G, Schindler DG. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci U S A. 1993;90(2):720-4.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , Issue.2 , pp. 720-724
    • Eshhar, Z.1    Waks, T.2    Gross, G.3    Schindler, D.G.4
  • 9
    • 84988805188 scopus 로고    scopus 로고
    • Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified T cells
    • 27605551
    • Turtle CJ, Hanafi LA, Berger C, Hudecek M, Pender B, Robinson E, Hawkins R, Chaney C, Cherian S, Chen X, et al. Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified T cells. Sci Transl Med. 2016;8(355):355ra116.
    • (2016) Sci Transl Med , vol.8 , Issue.355 , pp. 355ra116
    • Turtle, C.J.1    Hanafi, L.A.2    Berger, C.3    Hudecek, M.4    Pender, B.5    Robinson, E.6    Hawkins, R.7    Chaney, C.8    Cherian, S.9    Chen, X.10
  • 10
    • 84923118622 scopus 로고    scopus 로고
    • Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor
    • 1:CAS:528:DC%2BC2MXktlCntr4%3D 25154820
    • Kochenderfer JN, Dudley ME, Kassim SH, Somerville RP, Carpenter RO, Stetler-Stevenson M, Yang JC, Phan GQ, Hughes MS, Sherry RM, et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. J Clin Oncol. 2015;33(6):540-9.
    • (2015) J Clin Oncol , vol.33 , Issue.6 , pp. 540-549
    • Kochenderfer, J.N.1    Dudley, M.E.2    Kassim, S.H.3    Somerville, R.P.4    Carpenter, R.O.5    Stetler-Stevenson, M.6    Yang, J.C.7    Phan, G.Q.8    Hughes, M.S.9    Sherry, R.M.10
  • 11
    • 80051775476 scopus 로고    scopus 로고
    • T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • 1:CAS:528:DC%2BC3MXhtFOisL3N 21832238 3393096
    • Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, June CH. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med. 2011;3(95):95ra73.
    • (2011) Sci Transl Med , vol.3 , Issue.95 , pp. 95ra73
    • Kalos, M.1    Levine, B.L.2    Porter, D.L.3    Katz, S.4    Grupp, S.A.5    Bagg, A.6    June, C.H.7
  • 12
    • 84975172606 scopus 로고    scopus 로고
    • Durable remissions in children with relapsed/refractory ALL treated with T cells engineered with a CD19-targeted chimeric antigen receptor (CTL019)
    • Grupp SA, Maude SL, Shaw PA, Aplenc R, Barrett DM, Callahan C, Lacey SF, Levine BL, Melenhorst JJ, Motley L, et al. Durable remissions in children with relapsed/refractory ALL treated with T cells engineered with a CD19-targeted chimeric antigen receptor (CTL019). Blood. 2015;126(23):681.
    • (2015) Blood , vol.126 , Issue.23 , pp. 681
    • Grupp, S.A.1    Maude, S.L.2    Shaw, P.A.3    Aplenc, R.4    Barrett, D.M.5    Callahan, C.6    Lacey, S.F.7    Levine, B.L.8    Melenhorst, J.J.9    Motley, L.10
  • 13
    • 84997241574 scopus 로고    scopus 로고
    • Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia
    • 27887660 5124292
    • Cai B, Guo M, Wang Y, Zhang Y, Yang J, Guo Y, Dai H, Yu C, Sun Q, Qiao J, et al. Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia. J Hematol Oncol. 2016;9(1):131.
    • (2016) J Hematol Oncol , vol.9 , Issue.1 , pp. 131
    • Cai, B.1    Guo, M.2    Wang, Y.3    Zhang, Y.4    Yang, J.5    Guo, Y.6    Dai, H.7    Yu, C.8    Sun, Q.9    Qiao, J.10
  • 14
    • 85007206434 scopus 로고    scopus 로고
    • Treatment of CD20-directed chimeric antigen receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: An early phase IIa trial report
    • Zhang W-y, Wang Y, Guo Y-l, Dai H, Yang Q-m, Zhang Y-j, Zhang Y, Chen M-x, Wang C-m, Feng K-c, et al. Treatment of CD20-directed chimeric antigen receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an early phase IIa trial report. Signal Transduction TargetTher. 2016;1:16002.
    • (2016) Signal Transduction TargetTher , vol.1 , pp. 16002
    • Zhang, W.-Y.1    Wang, Y.2    Guo, Y.-L.3    Dai, H.4    Yang, Q.-M.5    Zhang, Y.-J.6    Zhang, Y.7    Chen, M.-X.8    Wang, C.-M.9    Feng, K.-C.10
  • 15
    • 85014625466 scopus 로고    scopus 로고
    • Autologous T Cells expressing CD30 chimeric antigen receptors for relapsed or refractory Hodgkin lymphoma: An open-label phase i trial
    • Wang CM, Wu ZQ, Wang Y, Guo YL, Dai HR, Wang XH, Li X, Zhang YJ, Zhang WY, Chen MX, et al. Autologous T Cells expressing CD30 chimeric antigen receptors for relapsed or refractory Hodgkin lymphoma: an open-label phase I trial. Clin Cancer Res. 2016. doi: 10.1158/1078-0432.CCR-16-1365.
    • (2016) Clin Cancer Res
    • Wang, C.M.1    Wu, Z.Q.2    Wang, Y.3    Guo, Y.L.4    Dai, H.R.5    Wang, X.H.6    Li, X.7    Zhang, Y.J.8    Zhang, W.Y.9    Chen, M.X.10
  • 16
    • 84960326834 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer
    • 1:CAS:528:DC%2BC28XksVygsb4%3D 26968708
    • Feng K, Guo Y, Dai H, Wang Y, Li X, Jia H, Han W. Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer. Sci China Life Sci. 2016;59(5):468-79.
    • (2016) Sci China Life Sci , vol.59 , Issue.5 , pp. 468-479
    • Feng, K.1    Guo, Y.2    Dai, H.3    Wang, Y.4    Li, X.5    Jia, H.6    Han, W.7
  • 20
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • 1:CAS:528:DC%2BC3cXitlaitb4%3D 20179677 2862534
    • Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, Rosenberg SA. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther. 2010;18(4):843-51.
    • (2010) Mol Ther , vol.18 , Issue.4 , pp. 843-851
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3    Dudley, M.E.4    Laurencot, C.M.5    Rosenberg, S.A.6
  • 21
    • 84933513655 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 (HER2) - Specific chimeric antigen receptor-modified T cells for the immunotherapy of HER2-positive sarcoma
    • 1:CAS:528:DC%2BC2MXhtFCnurfK 25800760 4429176
    • Ahmed N, Brawley VS, Hegde M, Robertson C, Ghazi A, Gerken C, Liu E, Dakhova O, Ashoori A, Corder A, et al. Human epidermal growth factor receptor 2 (HER2) - specific chimeric antigen receptor-modified T cells for the immunotherapy of HER2-positive sarcoma. J Clin Oncol. 2015;33(15):1688-96.
    • (2015) J Clin Oncol , vol.33 , Issue.15 , pp. 1688-1696
    • Ahmed, N.1    Brawley, V.S.2    Hegde, M.3    Robertson, C.4    Ghazi, A.5    Gerken, C.6    Liu, E.7    Dakhova, O.8    Ashoori, A.9    Corder, A.10
  • 22
    • 84942910678 scopus 로고    scopus 로고
    • Phase i hepatic immunotherapy for metastases study of intra-arterial chimeric antigen receptor-modified T-cell therapy for CEA+ liver metastases
    • 1:CAS:528:DC%2BC2MXht1SrsLrJ 25850950 4506253
    • Katz SC, Burga RA, McCormack E, Wang LJ, Mooring W, Point GR, Khare PD, Thorn M, Ma Q, Stainken BF, et al. Phase I hepatic immunotherapy for metastases study of intra-arterial chimeric antigen receptor-modified T-cell therapy for CEA+ liver metastases. Clin Cancer Res. 2015;21(14):3149-59.
    • (2015) Clin Cancer Res , vol.21 , Issue.14 , pp. 3149-3159
    • Katz, S.C.1    Burga, R.A.2    McCormack, E.3    Wang, L.J.4    Mooring, W.5    Point, G.R.6    Khare, P.D.7    Thorn, M.8    Ma, Q.9    Stainken, B.F.10
  • 25
    • 84966287066 scopus 로고    scopus 로고
    • Safety and response of incorporating CD19 chimeric antigen receptor T cell therapy in typical salvage regimens for children and young adults with acute lymphoblastic leukemia
    • Lee DW, Stetler-Stevenson M, Yuan CM, Fry TJ, Shah NN, Delbrook C, Yates B, Zhang H, Zhang L, Kochenderfer JN, et al. Safety and response of incorporating CD19 chimeric antigen receptor T cell therapy in typical salvage regimens for children and young adults with acute lymphoblastic leukemia. Blood. 2015;126(23):684.
    • (2015) Blood , vol.126 , Issue.23 , pp. 684
    • Lee, D.W.1    Stetler-Stevenson, M.2    Yuan, C.M.3    Fry, T.J.4    Shah, N.N.5    Delbrook, C.6    Yates, B.7    Zhang, H.8    Zhang, L.9    Kochenderfer, J.N.10
  • 27
    • 84931061879 scopus 로고    scopus 로고
    • CAR therapy for hematological cancers: Can success seen in the treatment of B-cell acute lymphoblastic leukemia be applied to other hematological malignancies?
    • 1:CAS:528:DC%2BC2MXpvV2ruro%3D 26065479 5238709
    • Pegram HJ, Smith EL, Rafiq S, Brentjens RJ. CAR therapy for hematological cancers: can success seen in the treatment of B-cell acute lymphoblastic leukemia be applied to other hematological malignancies? Immunotherapy. 2015;7(5):545-61.
    • (2015) Immunotherapy , vol.7 , Issue.5 , pp. 545-561
    • Pegram, H.J.1    Smith, E.L.2    Rafiq, S.3    Brentjens, R.J.4
  • 30
    • 84978953652 scopus 로고    scopus 로고
    • CD19 negative relapse in B-ALL treated with blinatumomab therapy: Avoiding the trap
    • Yannakou CK, Came N, Bajel AR, Juneja S. CD19 negative relapse in B-ALL treated with blinatumomab therapy: avoiding the trap. Blood. 2015;126:4983.
    • (2015) Blood , vol.126 , pp. 4983
    • Yannakou, C.K.1    Came, N.2    Bajel, A.R.3    Juneja, S.4
  • 31
    • 84950989868 scopus 로고    scopus 로고
    • Bispecific antibodies and their applications
    • 26692321 4687327
    • Fan G, Wang Z, Hao M, Li J. Bispecific antibodies and their applications. J Hematol Oncol. 2015;8:130.
    • (2015) J Hematol Oncol , vol.8 , pp. 130
    • Fan, G.1    Wang, Z.2    Hao, M.3    Li, J.4
  • 32
    • 84943302629 scopus 로고    scopus 로고
    • Increase of PD-L1 expressing B-precursor ALL cells in a patient resistant to the CD19/CD3-bispecific T cell engager antibody blinatumomab
    • 26449653 4599591
    • Kohnke T, Krupka C, Tischer J, Knosel T, Subklewe M. Increase of PD-L1 expressing B-precursor ALL cells in a patient resistant to the CD19/CD3-bispecific T cell engager antibody blinatumomab. J Hematol Oncol. 2015;8:111.
    • (2015) J Hematol Oncol , vol.8 , pp. 111
    • Kohnke, T.1    Krupka, C.2    Tischer, J.3    Knosel, T.4    Subklewe, M.5
  • 33
    • 84942853133 scopus 로고    scopus 로고
    • Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells
    • 26444983 4596481
    • Fan D, Li W, Yang Y, Zhang X, Zhang Q, Yan Y, Yang M, Wang J, Xiong D. Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells. J Hematol Oncol. 2015;8:108.
    • (2015) J Hematol Oncol , vol.8 , pp. 108
    • Fan, D.1    Li, W.2    Yang, Y.3    Zhang, X.4    Zhang, Q.5    Yan, Y.6    Yang, M.7    Wang, J.8    Xiong, D.9
  • 34
    • 85006220566 scopus 로고    scopus 로고
    • Complete remission after single agent blinatumomab in a patient with pre-B acute lymphoid leukemia relapsed and refractory to three prior regimens: HyperCVAD, high dose cytarabine mitoxantrone and CLAG
    • 27468365
    • Linder K, Gandhiraj D, Hanmantgad M, Seiter K, Liu D. Complete remission after single agent blinatumomab in a patient with pre-B acute lymphoid leukemia relapsed and refractory to three prior regimens: hyperCVAD, high dose cytarabine mitoxantrone and CLAG. Exp Hematol Oncol. 2015;5:20.
    • (2015) Exp Hematol Oncol , vol.5 , pp. 20
    • Linder, K.1    Gandhiraj, D.2    Hanmantgad, M.3    Seiter, K.4    Liu, D.5
  • 35
    • 84938628792 scopus 로고    scopus 로고
    • Blinatumomab: A bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia
    • 26337639 4558758
    • Wu J, Fu J, Zhang M, Liu D. Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia. J Hematol Oncol. 2015;8:104.
    • (2015) J Hematol Oncol , vol.8 , pp. 104
    • Wu, J.1    Fu, J.2    Zhang, M.3    Liu, D.4
  • 36
    • 84991501323 scopus 로고    scopus 로고
    • Catch me if you can: Leukemia escape after CD19-directed T cell immunotherapies
    • 1:CAS:528:DC%2BC28Xhs1Gnu7vL 27761200 5061074
    • Ruella M, Maus MV. Catch me if you can: leukemia escape after CD19-directed T cell immunotherapies. Comput Struct Biotechnol J. 2016;14:357-62.
    • (2016) Comput Struct Biotechnol J , vol.14 , pp. 357-362
    • Ruella, M.1    Maus, M.V.2
  • 37
    • 84920693049 scopus 로고    scopus 로고
    • Treatment of CD33-directed chimeric antigen receptor-modified T cells in one patient with relapsed and refractory acute myeloid leukemia
    • 1:CAS:528:DC%2BC2cXhsFyks7%2FE 25174587
    • Wang QS, Wang Y, Lv HY, Han QW, Fan H, Guo B, Wang LL, Han WD. Treatment of CD33-directed chimeric antigen receptor-modified T cells in one patient with relapsed and refractory acute myeloid leukemia. Mol Ther. 2015;23(1):184-91.
    • (2015) Mol Ther , vol.23 , Issue.1 , pp. 184-191
    • Wang, Q.S.1    Wang, Y.2    Lv, H.Y.3    Han, Q.W.4    Fan, H.5    Guo, B.6    Wang, L.L.7    Han, W.D.8
  • 38
    • 84887471195 scopus 로고    scopus 로고
    • Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma
    • 1:CAS:528:DC%2BC3sXhs1ClsL7J 3831041
    • Hegde M, Corder A, Chow KK, Mukherjee M, Ashoori A, Kew Y, Zhang YJ, Baskin DS, Merchant FA, Brawley VS, et al. Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma. Mol Ther. 2013;21(11):2087-101.
    • (2013) Mol Ther , vol.21 , Issue.11 , pp. 2087-2101
    • Hegde, M.1    Corder, A.2    Chow, K.K.3    Mukherjee, M.4    Ashoori, A.5    Kew, Y.6    Zhang, Y.J.7    Baskin, D.S.8    Merchant, F.A.9    Brawley, V.S.10
  • 40
    • 84991821871 scopus 로고    scopus 로고
    • Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
    • Perna F, Sadelain M. Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy. Transl Cancer Res. 2016;5(S2):S221-5.
    • (2016) Transl Cancer Res , vol.5 , Issue.S2 , pp. S221-S225
    • Perna, F.1    Sadelain, M.2
  • 41
    • 84971641150 scopus 로고    scopus 로고
    • Acquisition of a CD19 negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T cell therapy
    • 1:CAS:528:DC%2BC28Xhs1ent7vN 26907630
    • Gardner R, Wu D, Cherian S, Fang M, Hanafi LA, Finney O, Smithers H, Jensen MC, Riddell SR, Maloney DG, et al. Acquisition of a CD19 negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T cell therapy. Blood. 2016;127(20):2406-10.
    • (2016) Blood , vol.127 , Issue.20 , pp. 2406-2410
    • Gardner, R.1    Wu, D.2    Cherian, S.3    Fang, M.4    Hanafi, L.A.5    Finney, O.6    Smithers, H.7    Jensen, M.C.8    Riddell, S.R.9    Maloney, D.G.10
  • 42
    • 84979901487 scopus 로고    scopus 로고
    • CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
    • 1:CAS:528:DC%2BC28Xht12nsL3F 27460500 4974466
    • Jacoby E, Nguyen SM, Fountaine TJ, Welp K, Gryder B, Qin H, Yang Y, Chien CD, Seif AE, Lei H, et al. CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity. Nat Commun. 2016;7:12320.
    • (2016) Nat Commun , vol.7 , pp. 12320
    • Jacoby, E.1    Nguyen, S.M.2    Fountaine, T.J.3    Welp, K.4    Gryder, B.5    Qin, H.6    Yang, Y.7    Chien, C.D.8    Seif, A.E.9    Lei, H.10
  • 44
    • 84976597911 scopus 로고    scopus 로고
    • T cells expressing CD19/CD20 bi-specific chimeric antigen receptors prevent antigen escape by malignant B cells
    • Zah E, Lin MY, Silva-Benedict A, Jensen MC, Chen YY. T cells expressing CD19/CD20 bi-specific chimeric antigen receptors prevent antigen escape by malignant B cells. Cancer Immunol Res. 2016. doi: 10.1158/2326-6066.CIR-15-0231.
    • (2016) Cancer Immunol Res
    • Zah, E.1    Lin, M.Y.2    Silva-Benedict, A.3    Jensen, M.C.4    Chen, Y.Y.5
  • 47
    • 85014189415 scopus 로고    scopus 로고
    • Tales of antigen evasion from CAR therapy
    • 1:CAS:528:DC%2BC28XptVersLk%3D 27252092
    • Sadelain M. Tales of antigen evasion from CAR therapy. Cancer Immunol Res. 2016;4(6):473.
    • (2016) Cancer Immunol Res , vol.4 , Issue.6 , pp. 473
    • Sadelain, M.1
  • 48
    • 84926456239 scopus 로고    scopus 로고
    • AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells
    • 25879549 4389834
    • Fan D, Li Z, Zhang X, Yang Y, Yuan X, Zhang X, Yang M, Zhang Y, Xiong D. AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells. J Hematol Oncol. 2015;8:18.
    • (2015) J Hematol Oncol , vol.8 , pp. 18
    • Fan, D.1    Li, Z.2    Zhang, X.3    Yang, Y.4    Yuan, X.5    Zhang, X.6    Yang, M.7    Zhang, Y.8    Xiong, D.9
  • 49
    • 85008425546 scopus 로고    scopus 로고
    • Cocktail treatment with EGFR-specific and CD133-specific chimeric antigen receptor-modified T cells in a patient with advanced cholangiocarcinoma
    • 28057014 5217546
    • Feng KC, Guo YL, Liu Y, Dai HR, Wang Y, Lv HY, Huang JH, Yang QM, Han WD. Cocktail treatment with EGFR-specific and CD133-specific chimeric antigen receptor-modified T cells in a patient with advanced cholangiocarcinoma. J Hematol Oncol. 2017;10(1):4.
    • (2017) J Hematol Oncol , vol.10 , Issue.1 , pp. 4
    • Feng, K.C.1    Guo, Y.L.2    Liu, Y.3    Dai, H.R.4    Wang, Y.5    Lv, H.Y.6    Huang, J.H.7    Yang, Q.M.8    Han, W.D.9
  • 51
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • 1:CAS:528:DC%2BD3MXot1ahs7c%3D 11689955
    • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001;414(6859):105-11.
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 53
    • 84960172841 scopus 로고    scopus 로고
    • Overcoming antigen escape with CAR T-cell therapy
    • 1:CAS:528:DC%2BC2MXhvF2ltb7I 26637657
    • Jackson HJ, Brentjens RJ. Overcoming antigen escape with CAR T-cell therapy. Cancer Discov. 2015;5(12):1238-40.
    • (2015) Cancer Discov , vol.5 , Issue.12 , pp. 1238-1240
    • Jackson, H.J.1    Brentjens, R.J.2
  • 54
    • 0037302519 scopus 로고    scopus 로고
    • Determinant spreading and tumor responses after peptide-based cancer immunotherapy
    • 1:CAS:528:DC%2BD3sXltVGqsA%3D%3D 12547500
    • Ribas A, Timmerman JM, Butterfield LH, Economou JS. Determinant spreading and tumor responses after peptide-based cancer immunotherapy. Trends Immunol. 2003;24(2):58-61.
    • (2003) Trends Immunol , vol.24 , Issue.2 , pp. 58-61
    • Ribas, A.1    Timmerman, J.M.2    Butterfield, L.H.3    Economou, J.S.4
  • 55
    • 84976287948 scopus 로고    scopus 로고
    • Implications of minimal residual disease negative complete remission (MRD-CR) and allogeneic stem cell transplant on safety and clinical outcome of CD19-targeted 19-28z CAR modified T cells in adult patients with relapsed, refractory B-cell ALL
    • Park JH, Riviere I, Wang X, Bernal Y, Purdon T, Halton E, Wang Y, Curran KJ, Sauter CS, Sadelain M, et al. Implications of minimal residual disease negative complete remission (MRD-CR) and allogeneic stem cell transplant on safety and clinical outcome of CD19-targeted 19-28z CAR modified T cells in adult patients with relapsed, refractory B-cell ALL. Blood. 2015;126(23):682.
    • (2015) Blood , vol.126 , Issue.23 , pp. 682
    • Park, J.H.1    Riviere, I.2    Wang, X.3    Bernal, Y.4    Purdon, T.5    Halton, E.6    Wang, Y.7    Curran, K.J.8    Sauter, C.S.9    Sadelain, M.10
  • 56
    • 51349139499 scopus 로고    scopus 로고
    • EGF receptor variant III as a target antigen for tumor immunotherapy
    • 18767947
    • Li G, Wong AJ. EGF receptor variant III as a target antigen for tumor immunotherapy. Expert Rev Vaccines. 2008;7(7):977-85.
    • (2008) Expert Rev Vaccines , vol.7 , Issue.7 , pp. 977-985
    • Li, G.1    Wong, A.J.2
  • 59
    • 84859068537 scopus 로고    scopus 로고
    • T-cell-receptor-like antibodies - Generation, function and applications
    • 22361332
    • Dahan R, Reiter Y. T-cell-receptor-like antibodies - generation, function and applications. Expert Rev Mol Med. 2012;14:e6.
    • (2012) Expert Rev Mol Med , vol.14 , pp. e6
    • Dahan, R.1    Reiter, Y.2
  • 61
    • 84976581044 scopus 로고    scopus 로고
    • A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells
    • 1:CAS:528:DC%2BC28Xos1Wms7o%3D 27265873
    • Ma Q, Garber HR, Lu S, He H, Tallis E, Ding X, Sergeeva A, Wood MS, Dotti G, Salvado B, et al. A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells. Cytotherapy. 2016;18(8):985-94.
    • (2016) Cytotherapy , vol.18 , Issue.8 , pp. 985-994
    • Ma, Q.1    Garber, H.R.2    Lu, S.3    He, H.4    Tallis, E.5    Ding, X.6    Sergeeva, A.7    Wood, M.S.8    Dotti, G.9    Salvado, B.10
  • 62
    • 84891786837 scopus 로고    scopus 로고
    • Anti-melanoma activity of T cells redirected with a TCR-like chimeric antigen receptor
    • 24389689 3880964
    • Zhang G, Wang L, Cui H, Wang X, Zhang G, Ma J, Han H, He W, Wang W, Zhao Y, et al. Anti-melanoma activity of T cells redirected with a TCR-like chimeric antigen receptor. Sci Rep. 2014;4:3571.
    • (2014) Sci Rep , vol.4 , pp. 3571
    • Zhang, G.1    Wang, L.2    Cui, H.3    Wang, X.4    Zhang, G.5    Ma, J.6    Han, H.7    He, W.8    Wang, W.9    Zhao, Y.10
  • 63
    • 84954168391 scopus 로고    scopus 로고
    • Therapeutic potential of T cell chimeric antigen receptors (CARs) in cancer treatment: Counteracting off-tumor toxicities for safe CAR T cell therapy
    • 1:CAS:528:DC%2BC28Xks1SrsA%3D%3D 26738472
    • Gross G, Eshhar Z. Therapeutic potential of T cell chimeric antigen receptors (CARs) in cancer treatment: counteracting off-tumor toxicities for safe CAR T cell therapy. Annu Rev Pharmacol Toxicol. 2016;56:59-83.
    • (2016) Annu Rev Pharmacol Toxicol , vol.56 , pp. 59-83
    • Gross, G.1    Eshhar, Z.2
  • 65
    • 84872196489 scopus 로고    scopus 로고
    • Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
    • 1:CAS:528:DC%2BC38XhvVersr%2FM 23242161
    • Kloss CC, Condomines M, Cartellieri M, Bachmann M, Sadelain M. Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells. Nat Biotechnol. 2013;31(1):71-5.
    • (2013) Nat Biotechnol , vol.31 , Issue.1 , pp. 71-75
    • Kloss, C.C.1    Condomines, M.2    Cartellieri, M.3    Bachmann, M.4    Sadelain, M.5
  • 66
    • 84872189029 scopus 로고    scopus 로고
    • Double or nothing on cancer immunotherapy
    • 1:CAS:528:DC%2BC3sXkvF2jtA%3D%3D 23302931
    • Hanada K, Restifo NP. Double or nothing on cancer immunotherapy. Nat Biotechnol. 2013;31(1):33-4.
    • (2013) Nat Biotechnol , vol.31 , Issue.1 , pp. 33-34
    • Hanada, K.1    Restifo, N.P.2
  • 67
    • 84958230998 scopus 로고    scopus 로고
    • Engineering customized cell sensing and response behaviors using synthetic notch receptors
    • 1:CAS:528:DC%2BC28Xhs12gt70%3D 26830878 4752866
    • Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. Engineering customized cell sensing and response behaviors using synthetic notch receptors. Cell. 2016;164(4):780-91.
    • (2016) Cell , vol.164 , Issue.4 , pp. 780-791
    • Morsut, L.1    Roybal, K.T.2    Xiong, X.3    Gordley, R.M.4    Coyle, S.M.5    Thomson, M.6    Lim, W.A.7
  • 68
    • 84958214384 scopus 로고    scopus 로고
    • Precision tumor recognition by T cells with combinatorial antigen-sensing circuits
    • 1:CAS:528:DC%2BC28Xhs12gt78%3D 26830879 4752902
    • Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. Precision tumor recognition by T cells with combinatorial antigen-sensing circuits. Cell. 2016;164(4):770-9.
    • (2016) Cell , vol.164 , Issue.4 , pp. 770-779
    • Roybal, K.T.1    Rupp, L.J.2    Morsut, L.3    Walker, W.J.4    McNally, K.A.5    Park, J.S.6    Lim, W.A.7
  • 69
    • 84963613108 scopus 로고    scopus 로고
    • Receptor combinations hone T-cell therapy
    • 1:CAS:528:DC%2BC28Xlsl2hurY%3D 27054992
    • Blankenstein T. Receptor combinations hone T-cell therapy. Nat Biotechnol. 2016;34(4):389-91.
    • (2016) Nat Biotechnol , vol.34 , Issue.4 , pp. 389-391
    • Blankenstein, T.1
  • 70
    • 84891708419 scopus 로고    scopus 로고
    • PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses
    • 24337479 4238416
    • Fedorov VD, Themeli M, Sadelain M. PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses. Sci Transl Med. 2013;5(215):215ra172.
    • (2013) Sci Transl Med , vol.5 , Issue.215 , pp. 215ra172
    • Fedorov, V.D.1    Themeli, M.2    Sadelain, M.3
  • 73
    • 10344265510 scopus 로고    scopus 로고
    • T cell activation by antibody-like immunoreceptors: Increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity
    • 1:CAS:528:DC%2BD2cXhtVCqurjI 15585893
    • Chmielewski M, Hombach A, Heuser C, Adams GP, Abken H. T cell activation by antibody-like immunoreceptors: increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity. J Immunol. 2004;173(12):7647-53.
    • (2004) J Immunol , vol.173 , Issue.12 , pp. 7647-7653
    • Chmielewski, M.1    Hombach, A.2    Heuser, C.3    Adams, G.P.4    Abken, H.5
  • 74
    • 84942907010 scopus 로고    scopus 로고
    • Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent antitumor activity
    • 1:CAS:528:DC%2BC2MXhsVWqtLnK 26330164 4624228
    • Caruso HG, Hurton LV, Najjar A, Rushworth D, Ang S, Olivares S, Mi T, Switzer K, Singh H, Huls H, et al. Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent antitumor activity. Cancer Res. 2015;75(17):3505-18.
    • (2015) Cancer Res , vol.75 , Issue.17 , pp. 3505-3518
    • Caruso, H.G.1    Hurton, L.V.2    Najjar, A.3    Rushworth, D.4    Ang, S.5    Olivares, S.6    Mi, T.7    Switzer, K.8    Singh, H.9    Huls, H.10
  • 75
    • 84942885584 scopus 로고    scopus 로고
    • Affinity-tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index against tumors in mice
    • 1:CAS:528:DC%2BC2MXhsVWqtLbP 26330166 4560113
    • Liu X, Jiang S, Fang C, Yang S, Olalere D, Pequignot EC, Cogdill AP, Li N, Ramones M, Granda B, et al. Affinity-tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index against tumors in mice. Cancer Res. 2015;75(17):3596-607.
    • (2015) Cancer Res , vol.75 , Issue.17 , pp. 3596-3607
    • Liu, X.1    Jiang, S.2    Fang, C.3    Yang, S.4    Olalere, D.5    Pequignot, E.C.6    Cogdill, A.P.7    Li, N.8    Ramones, M.9    Granda, B.10
  • 76
    • 84958744448 scopus 로고    scopus 로고
    • Adoptive T cell therapies: A comparison of T cell receptors and chimeric antigen receptors
    • 1:CAS:528:DC%2BC2MXhvFems7bE 26705086
    • Harris DT, Kranz DM. Adoptive T cell therapies: a comparison of T cell receptors and chimeric antigen receptors. Trends Pharmacol Sci. 2016;37(3):220-30.
    • (2016) Trends Pharmacol Sci , vol.37 , Issue.3 , pp. 220-230
    • Harris, D.T.1    Kranz, D.M.2
  • 79
    • 84954236800 scopus 로고    scopus 로고
    • Prospects for gene-engineered T cell immunotherapy for solid cancers
    • 1:CAS:528:DC%2BC28XjvFOltQ%3D%3D 26735408
    • Klebanoff CA, Rosenberg SA, Restifo NP. Prospects for gene-engineered T cell immunotherapy for solid cancers. Nat Med. 2016;22(1):26-36.
    • (2016) Nat Med , vol.22 , Issue.1 , pp. 26-36
    • Klebanoff, C.A.1    Rosenberg, S.A.2    Restifo, N.P.3
  • 80
    • 84924750926 scopus 로고    scopus 로고
    • Going viral: Chimeric antigen receptor T-cell therapy for hematological malignancies
    • 1:CAS:528:DC%2BC2cXitFSnsrzL 25510272
    • Gill S, June CH. Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies. Immunol Rev. 2015;263(1):68-89.
    • (2015) Immunol Rev , vol.263 , Issue.1 , pp. 68-89
    • Gill, S.1    June, C.H.2
  • 81
    • 78549253550 scopus 로고    scopus 로고
    • Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor
    • 1:CAS:528:DC%2BC3cXhsVWmsL3F 20926399 2982929
    • Zhao Y, Moon E, Carpenito C, Paulos CM, Liu X, Brennan AL, Chew A, Carroll RG, Scholler J, Levine BL, et al. Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor. Cancer Res. 2010;70(22):9053-61.
    • (2010) Cancer Res , vol.70 , Issue.22 , pp. 9053-9061
    • Zhao, Y.1    Moon, E.2    Carpenito, C.3    Paulos, C.M.4    Liu, X.5    Brennan, A.L.6    Chew, A.7    Carroll, R.G.8    Scholler, J.9    Levine, B.L.10
  • 83
    • 85014138271 scopus 로고    scopus 로고
    • Abstract CT105: Safety and feasibility of chimeric antigen receptor modified T cells directed against mesothelin (CART-meso) in patients with mesothelin expressing cancers
    • Tanyi JL, Haas AR, Beatty GL, Morgan MA, Stashwick CJ, O'Hara MH, Porter DL, Maus MV, Levine BL, Lacey SF, et al. Abstract CT105: Safety and feasibility of chimeric antigen receptor modified T cells directed against mesothelin (CART-meso) in patients with mesothelin expressing cancers. Cancer Res. 2015;75(15 Supplement):CT105.
    • (2015) Cancer Res , vol.75 , Issue.15 , pp. CT105
    • Tanyi, J.L.1    Haas, A.R.2    Beatty, G.L.3    Morgan, M.A.4    Stashwick, C.J.5    O'Hara, M.H.6    Porter, D.L.7    Maus, M.V.8    Levine, B.L.9    Lacey, S.F.10
  • 84
    • 84954059507 scopus 로고    scopus 로고
    • Design of chimeric antigen receptors with integrated controllable transient functions
    • 1:CAS:528:DC%2BC28XnsFKrsQ%3D%3D 26750734 4707440
    • Juillerat A, Marechal A, Filhol JM, Valton J, Duclert A, Poirot L, Duchateau P. Design of chimeric antigen receptors with integrated controllable transient functions. Sci Rep. 2016;6:18950.
    • (2016) Sci Rep , vol.6 , pp. 18950
    • Juillerat, A.1    Marechal, A.2    Filhol, J.M.3    Valton, J.4    Duclert, A.5    Poirot, L.6    Duchateau, P.7
  • 85
    • 84945217637 scopus 로고    scopus 로고
    • Remote control of therapeutic T cells through a small molecule-gated chimeric receptor
    • 26405231 4721629
    • Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science. 2015;350(6258):aab4077.
    • (2015) Science , vol.350 , Issue.6258 , pp. aab4077
    • Wu, C.Y.1    Roybal, K.T.2    Puchner, E.M.3    Onuffer, J.4    Lim, W.A.5
  • 89
    • 84943398830 scopus 로고    scopus 로고
    • Retargeted human avidin-CAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging
    • 26124178 4695148
    • Liu K, Liu X, Peng Z, Sun H, Zhang M, Zhang J, Liu S, Hao L, Lu G, Zheng K, et al. Retargeted human avidin-CAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging. Oncotarget. 2015;6(27):23735-47.
    • (2015) Oncotarget , vol.6 , Issue.27 , pp. 23735-23747
    • Liu, K.1    Liu, X.2    Peng, Z.3    Sun, H.4    Zhang, M.5    Zhang, J.6    Liu, S.7    Hao, L.8    Lu, G.9    Zheng, K.10
  • 91
    • 84926433030 scopus 로고    scopus 로고
    • Improving the safety of cell therapy products by suicide gene transfer
    • 25505885 4245885
    • Jones BS, Lamb LS, Goldman F, Di Stasi A. Improving the safety of cell therapy products by suicide gene transfer. Front Pharmacol. 2014;5:254.
    • (2014) Front Pharmacol , vol.5 , pp. 254
    • Jones, B.S.1    Lamb, L.S.2    Goldman, F.3    Di Stasi, A.4
  • 94
    • 80051589534 scopus 로고    scopus 로고
    • A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells
    • 1:CAS:528:DC%2BC3MXhtVCnurjN 21653320 3152493
    • Wang X, Chang WC, Wong CW, Colcher D, Sherman M, Ostberg JR, Forman SJ, Riddell SR, Jensen MC. A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells. Blood. 2011;118(5):1255-63.
    • (2011) Blood , vol.118 , Issue.5 , pp. 1255-1263
    • Wang, X.1    Chang, W.C.2    Wong, C.W.3    Colcher, D.4    Sherman, M.5    Ostberg, J.R.6    Forman, S.J.7    Riddell, S.R.8    Jensen, M.C.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.