메뉴 건너뛰기




Volumn 8, Issue 1, 2017, Pages

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; FAS LIGAND; TAMOXIFEN; CANCER VACCINE; FAS PROTEIN, MOUSE; FASL PROTEIN, MOUSE; FASLG PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6;

EID: 85034071655     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-00784-1     Document Type: Article
Times cited : (182)

References (55)
  • 1
    • 84894559188 scopus 로고    scopus 로고
    • Tumour antigens recognized by T lymphocytes: At the core of cancer immunotherapy
    • Coulie, P. G., Van den Eynde, B. J., van der Bruggen, P. & Boon, T. Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy. Nat. Rev. Cancer 14, 135-146 (2014).
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 135-146
    • Coulie, P.G.1    Van Den Eynde, B.J.2    Van Der Bruggen, P.3    Boon, T.4
  • 2
    • 33645518844 scopus 로고    scopus 로고
    • An inducible mouse model of melanoma expressing a defined tumor antigen
    • Huijbers, I. J. et al. An inducible mouse model of melanoma expressing a defined tumor antigen. Cancer Res. 66, 3278-3286 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 3278-3286
    • Huijbers, I.J.1
  • 3
    • 84869239093 scopus 로고    scopus 로고
    • Epithelial-mesenchymal-transition-like and TGFbeta pathways associated with autochthonous inflammatory melanoma development in mice
    • Wehbe, M. et al. Epithelial-mesenchymal-transition-like and TGFbeta pathways associated with autochthonous inflammatory melanoma development in mice. PLoS ONE 7, e49419 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e49419
    • Wehbe, M.1
  • 4
    • 77951708030 scopus 로고    scopus 로고
    • Tumor-initiated inflammation overrides protective adaptive immunity in an induced melanoma model in mice
    • Soudja, S. M. et al. Tumor-initiated inflammation overrides protective adaptive immunity in an induced melanoma model in mice. Cancer Res. 70, 3515-3525 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 3515-3525
    • Soudja, S.M.1
  • 5
    • 84961221351 scopus 로고    scopus 로고
    • Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
    • Hugo, W. et al. Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma. Cell 165, 35-44 (2016).
    • (2016) Cell , vol.165 , pp. 35-44
    • Hugo, W.1
  • 6
    • 34249782279 scopus 로고    scopus 로고
    • Comparative prime-boost vaccinations using Semliki Forest virus, adenovirus, and ALVAC vectors demonstrate differences in the generation of a protective central memory CTL response against the P815 tumor
    • Naslund, T. I. et al. Comparative prime-boost vaccinations using Semliki Forest virus, adenovirus, and ALVAC vectors demonstrate differences in the generation of a protective central memory CTL response against the P815 tumor. J. Immunol. 178, 6761-6769 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 6761-6769
    • Naslund, T.I.1
  • 7
    • 0024316157 scopus 로고
    • Structure of the gene coding for tum-transplantation antigen P91A A peptide encoded by the mutated exon is recognized with Ld by cytolytic T cells
    • Lurquin, C. et al. Structure of the gene coding for tum-transplantation antigen P91A. A peptide encoded by the mutated exon is recognized with Ld by cytolytic T cells. Cell 58, 293-303 (1989).
    • (1989) Cell , vol.58 , pp. 293-303
    • Lurquin, C.1
  • 8
    • 46949109577 scopus 로고    scopus 로고
    • Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness
    • Willimsky, G. et al. Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness. J. Exp. Med. 205, 1687-1700 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 1687-1700
    • Willimsky, G.1
  • 9
    • 24344436369 scopus 로고    scopus 로고
    • Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance
    • Willimsky, G. & Blankenstein, T. Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance. Nature 437, 141-146 (2005).
    • (2005) Nature , vol.437 , pp. 141-146
    • Willimsky, G.1    Blankenstein, T.2
  • 10
    • 1842423787 scopus 로고    scopus 로고
    • Thymocyte-intrinsic genetic factors influence CD8 T cell lineage commitment and affect selection of a tumor-reactive TCR
    • Shanker, A. et al. Thymocyte-intrinsic genetic factors influence CD8 T cell lineage commitment and affect selection of a tumor-reactive TCR. J. Immunol. 172, 5069-5077 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 5069-5077
    • Shanker, A.1
  • 11
    • 37549018148 scopus 로고    scopus 로고
    • Use of a fluorescently labeled poly-caspase inhibitor for in vivo detection of apoptosis related to vascular-targeting agent arsenic trioxide for cancer therapy
    • Griffin, R. J. et al. Use of a fluorescently labeled poly-caspase inhibitor for in vivo detection of apoptosis related to vascular-targeting agent arsenic trioxide for cancer therapy. Technol. Cancer Res. Treat. 6, 651-654 (2007).
    • (2007) Technol. Cancer Res. Treat. , vol.6 , pp. 651-654
    • Griffin, R.J.1
  • 12
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells
    • Spranger, S. et al. Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. Sci. Transl. Med. 5, 200ra116 (2013).
    • (2013) Sci. Transl. Med. , vol.5 , pp. 200ra116
    • Spranger, S.1
  • 13
    • 84858007569 scopus 로고    scopus 로고
    • Interferon-gamma-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway
    • Chen, J. et al. Interferon-gamma-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway. Immunobiology 217, 385-393 (2012).
    • (2012) Immunobiology , vol.217 , pp. 385-393
    • Chen, J.1
  • 14
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll, D. M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12, 252-264 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 15
    • 84962034404 scopus 로고    scopus 로고
    • Tumoral immune resistance mediated by enzymes that degrade tryptophan
    • van Baren, N. & Van den Eynde, B. J. Tumoral immune resistance mediated by enzymes that degrade tryptophan. Cancer Immunol. Res. 3, 978-985 (2015).
    • (2015) Cancer Immunol. Res. , vol.3 , pp. 978-985
    • Van Baren, N.1    Van Den Eynde, B.J.2
  • 17
    • 0032125574 scopus 로고    scopus 로고
    • IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: Requirement of STAT1 protein for upregulation of Fas and FasL expression
    • Xu, X., Fu, X. Y., Plate, J. & Chong, A. S. IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for upregulation of Fas and FasL expression. Cancer Res. 58, 2832-2837 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 2832-2837
    • Xu, X.1    Fu, X.Y.2    Plate, J.3    Chong, A.S.4
  • 18
    • 84942693817 scopus 로고    scopus 로고
    • Blocking tumor necrosis factor alpha enhances CD8 T-celldependent immunity in experimental melanoma
    • Bertrand, F. et al. Blocking tumor necrosis factor alpha enhances CD8 T-celldependent immunity in experimental melanoma. Cancer Res. 75, 2619-2628 (2015).
    • (2015) Cancer Res. , vol.75 , pp. 2619-2628
    • Bertrand, F.1
  • 20
    • 78649586268 scopus 로고    scopus 로고
    • The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity
    • Youn, J. I. & Gabrilovich, D. I. The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity. Eur. J. Immunol. 40, 2969-2975 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , pp. 2969-2975
    • Youn, J.I.1    Gabrilovich, D.I.2
  • 21
    • 84937519151 scopus 로고    scopus 로고
    • CCL2 promotes colorectal carcinogenesis by enhancing polymorphonuclear myeloid-derived suppressor cell population and function
    • Chun, E. et al. CCL2 promotes colorectal carcinogenesis by enhancing polymorphonuclear myeloid-derived suppressor cell population and function. Cell Rep. 12, 244-257 (2015).
    • (2015) Cell Rep. , vol.12 , pp. 244-257
    • Chun, E.1
  • 22
    • 60549088732 scopus 로고    scopus 로고
    • Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
    • Rodriguez, P. C. et al. Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res. 69, 1553-1560 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 1553-1560
    • Rodriguez, P.C.1
  • 23
    • 84855301911 scopus 로고    scopus 로고
    • Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice
    • Youn, J. I., Collazo, M., Shalova, I. N., Biswas, S. K. & Gabrilovich, D. I. Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. J. Leukoc. Biol. 91, 167-181 (2012).
    • (2012) J. Leukoc. Biol. , vol.91 , pp. 167-181
    • Youn, J.I.1    Collazo, M.2    Shalova, I.N.3    Biswas, S.K.4    Gabrilovich, D.I.5
  • 25
    • 84866762166 scopus 로고    scopus 로고
    • The pros and cons of chemokines in tumor immunology
    • Viola, A., Sarukhan, A., Bronte, V. & Molon, B. The pros and cons of chemokines in tumor immunology. Trends Immunol. 33, 496-504 (2012).
    • (2012) Trends Immunol. , vol.33 , pp. 496-504
    • Viola, A.1    Sarukhan, A.2    Bronte, V.3    Molon, B.4
  • 26
    • 84959542771 scopus 로고    scopus 로고
    • The nature of myeloidderived suppressor cells in the tumor microenvironment
    • Kumar, V., Patel, S., Tcyganov, E. & Gabrilovich, D. I. The nature of myeloidderived suppressor cells in the tumor microenvironment. Trends Immunol. 37, 208-220 (2016).
    • (2016) Trends Immunol. , vol.37 , pp. 208-220
    • Kumar, V.1    Patel, S.2    Tcyganov, E.3    Gabrilovich, D.I.4
  • 27
    • 85027923251 scopus 로고    scopus 로고
    • Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer
    • Youn, J. I. et al. Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Nat. Immunol. 14, 211-220 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 211-220
    • Youn, J.I.1
  • 28
    • 0032777102 scopus 로고    scopus 로고
    • Cell death induced by the Fas/Fas ligand pathway and its role in pathology
    • Waring, P. & Mullbacher, A. Cell death induced by the Fas/Fas ligand pathway and its role in pathology. Immunol. Cell Biol. 77, 312-317 (1999).
    • (1999) Immunol. Cell Biol. , vol.77 , pp. 312-317
    • Waring, P.1    Mullbacher, A.2
  • 29
    • 0036215202 scopus 로고    scopus 로고
    • Activation-induced cell death: The controversial role of fas and fas ligand in immune privilege and tumour counterattack
    • Maher, S., Toomey, D., Condron, C. & Bouchier-Hayes, D. Activation-induced cell death: the controversial role of fas and fas ligand in immune privilege and tumour counterattack. Immunol. Cell Biol. 80, 131-137 (2002).
    • (2002) Immunol. Cell Biol. , vol.80 , pp. 131-137
    • Maher, S.1    Toomey, D.2    Condron, C.3    Bouchier-Hayes, D.4
  • 30
    • 0025159229 scopus 로고
    • Lymphocytic infiltration in uveal malignant melanoma
    • de la Cruz, P. O. Jr., Specht, C. S. & McLean, I. W. Lymphocytic infiltration in uveal malignant melanoma. Cancer 65, 112-115 (1990).
    • (1990) Cancer , vol.65 , pp. 112-115
    • DeLa Cruz, P.O.1    Specht, C.S.2    McLean, I.W.3
  • 32
    • 33745320149 scopus 로고    scopus 로고
    • Mononuclear cell infiltration in clear-cell renal cell carcinoma independently predicts patient survival
    • Webster, W. S. et al. Mononuclear cell infiltration in clear-cell renal cell carcinoma independently predicts patient survival. Cancer 107, 46-53 (2006).
    • (2006) Cancer , vol.107 , pp. 46-53
    • Webster, W.S.1
  • 33
    • 10544232277 scopus 로고    scopus 로고
    • Melanoma cell expression of Fas (Apo-1/CD95) ligand: Implications for tumor immune escape
    • Hahne, M. et al. Melanoma cell expression of Fas (Apo-1/CD95) ligand: implications for tumor immune escape. Science 274, 1363-1366 (1996).
    • (1996) Science , vol.274 , pp. 1363-1366
    • Hahne, M.1
  • 34
    • 0031042972 scopus 로고    scopus 로고
    • Antitumor effect of locally produced CD95 ligand
    • Seino, K., Kayagaki, N., Okumura, K. & Yagita, H. Antitumor effect of locally produced CD95 ligand. Nat. Med. 3, 165-170 (1997).
    • (1997) Nat. Med. , vol.3 , pp. 165-170
    • Seino, K.1    Kayagaki, N.2    Okumura, K.3    Yagita, H.4
  • 35
    • 0031472398 scopus 로고    scopus 로고
    • Gene transfer of Fas ligand induces tumor regression in vivo
    • Arai, H.,Gordon,D.,Nabel, E.G.&Nabel, G. J.Gene transfer of Fas ligand induces tumor regression in vivo. Proc. Natl Acad. Sci. USA 94, 13862-13867 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 13862-13867
    • Arai, H.1    Gordon, D.2    Nabel, E.G.3    Nabel, G.J.4
  • 36
    • 0034080750 scopus 로고    scopus 로고
    • Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape
    • Restifo, N. P. Not so Fas: re-evaluating the mechanisms of immune privilege and tumor escape. Nat. Med. 6, 493-495 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 493-495
    • Restifo, N.P.1
  • 37
    • 0028909197 scopus 로고
    • Fas ligand mediates activation-induced cell death in human T lymphocytes
    • Alderson, M. R. et al. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181, 71-77 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 71-77
    • Alderson, M.R.1
  • 38
    • 70349694386 scopus 로고    scopus 로고
    • Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
    • LA, O. R. et al. Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature 461, 659-663 (2009).
    • (2009) Nature , vol.461 , pp. 659-663
    • La, O.R.1
  • 39
    • 27544457676 scopus 로고    scopus 로고
    • Addressing the "Fas counterattack" controversy: Blocking fas ligand expression suppresses tumor immune evasion of colon cancer in vivo
    • Ryan, A. E., Shanahan, F., O'Connell, J. & Houston, A. M. Addressing the "Fas counterattack" controversy: blocking fas ligand expression suppresses tumor immune evasion of colon cancer in vivo. Cancer Res. 65, 9817-9823 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 9817-9823
    • Ryan, A.E.1    Shanahan, F.2    O'Connell, J.3    Houston, A.M.4
  • 40
    • 84902124970 scopus 로고    scopus 로고
    • Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors
    • Motz, G. T. et al. Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors. Nat. Med. 20, 607-615 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 607-615
    • Motz, G.T.1
  • 41
    • 84956642934 scopus 로고    scopus 로고
    • Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy
    • Klebanoff, C. A. et al. Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy. J. Clin. Invest. 126, 318-334 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 318-334
    • Klebanoff, C.A.1
  • 42
    • 0036779576 scopus 로고    scopus 로고
    • Functional significance of the perforin/granzyme cell death pathway
    • Trapani, J. A. & Smyth, M. J. Functional significance of the perforin/granzyme cell death pathway. Nat. Rev. Immunol. 2, 735-747 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 735-747
    • Trapani, J.A.1    Smyth, M.J.2
  • 43
    • 84873472673 scopus 로고    scopus 로고
    • Fas expression by tumor stroma is required for cancer eradication
    • Listopad, J. J. et al. Fas expression by tumor stroma is required for cancer eradication. Proc. Natl Acad. Sci. USA 110, 2276-2281 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 2276-2281
    • Listopad, J.J.1
  • 44
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A. & Nagata, S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317 (1992).
    • (1992) Nature , vol.356 , pp. 314-317
    • Watanabe-Fukunaga, R.1    Brannan, C.I.2    Copeland, N.G.3    Jenkins, N.A.4    Nagata, S.5
  • 45
    • 0028485743 scopus 로고
    • The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice
    • Singer, G. G. & Abbas, A. K. The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1, 365-371 (1994).
    • (1994) Immunity , vol.1 , pp. 365-371
    • Singer, G.G.1    Abbas, A.K.2
  • 46
    • 0028980902 scopus 로고
    • Fas and Fas ligand: Lpr and gld mutations
    • Nagata, S. & Suda, T. Fas and Fas ligand: lpr and gld mutations. Immunol. Today 16, 39-43 (1995).
    • (1995) Immunol. Today , vol.16 , pp. 39-43
    • Nagata, S.1    Suda, T.2
  • 47
    • 0021350056 scopus 로고
    • A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice
    • Roths, J. B., Murphy, E. D. & Eicher, E. M. A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice. J. Exp. Med. 159, 1-20 (1984).
    • (1984) J. Exp. Med. , vol.159 , pp. 1-20
    • Roths, J.B.1    Murphy, E.D.2    Eicher, E.M.3
  • 48
    • 0020546609 scopus 로고
    • Escape of mouse mastocytoma P815 after nearly complete rejection is due to antigen-loss variants rather than immunosuppression
    • Uyttenhove, C., Maryanski, J. & Boon, T. Escape of mouse mastocytoma P815 after nearly complete rejection is due to antigen-loss variants rather than immunosuppression. J. Exp. Med. 157, 1040-1052 (1983).
    • (1983) J. Exp. Med. , vol.157 , pp. 1040-1052
    • Uyttenhove, C.1    Maryanski, J.2    Boon, T.3
  • 49
    • 0026784914 scopus 로고
    • Mouse tumor rejection antigens P815A and P815B: Two epitopes carried by a single peptide
    • Lethé, B., Van den Eynde, B., Van Pel, A., Corradin, G. & Boon, T. Mouse tumor rejection antigens P815A and P815B: two epitopes carried by a single peptide. Eur. J. Immunol. 22, 2283-2288 (1992).
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2283-2288
    • Lethé, B.1    Van Den Eynde, B.2    Van Pel, A.3    Corradin, G.4    Boon, T.5
  • 50
    • 0029009835 scopus 로고
    • Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine anti-tumor cytolytic T lymphocytes in vitro
    • Gajewski, T. F., Renauld, J.-C., Van Pel, A. & Boon, T. Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine anti-tumor cytolytic T lymphocytes in vitro. J. Immunol. 154, 5637-5648 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 5637-5648
    • Gajewski, T.F.1    Renauld, J.-C.2    Van Pel, A.3    Boon, T.4
  • 51
    • 0031767121 scopus 로고    scopus 로고
    • The shared tumor-specific antigen encoded by mouse gene P1A is a target not only for cytolytic T lymphocytes but also for tumor rejection
    • Brändle, D. et al. The shared tumor-specific antigen encoded by mouse gene P1A is a target not only for cytolytic T lymphocytes but also for tumor rejection. Eur. J. Immunol. 28, 4010-4019 (1998).
    • (1998) Eur. J. Immunol. , vol.28 , pp. 4010-4019
    • Brändle, D.1
  • 52
    • 84954387067 scopus 로고    scopus 로고
    • Non-clinical safety evaluation of repeated intramuscular administration of the AS15 immunostimulant combined with various antigens in rabbits and cynomolgus monkeys
    • Garcon, N. et al. Non-clinical safety evaluation of repeated intramuscular administration of the AS15 immunostimulant combined with various antigens in rabbits and cynomolgus monkeys. J. Appl. Toxicol. 36, 238-256 (2016).
    • (2016) J. Appl. Toxicol. , vol.36 , pp. 238-256
    • Garcon, N.1
  • 53
    • 0037105414 scopus 로고    scopus 로고
    • TNF-mediated toxicity after massive induction of specific CD8+T cells following immunization of mice with a tumor-specific peptide
    • Bilsborough, J. et al. TNF-mediated toxicity after massive induction of specific CD8+T cells following immunization of mice with a tumor-specific peptide. J. Immunol. 169, 3053-3060 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 3053-3060
    • Bilsborough, J.1
  • 54
    • 84855370170 scopus 로고    scopus 로고
    • Minimal tolerance to a tumor antigen encoded by a cancergermline gene
    • Huijbers, I. J. et al. Minimal tolerance to a tumor antigen encoded by a cancergermline gene. J. Immunol. 188, 111-121 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 111-121
    • Huijbers, I.J.1
  • 55
    • 0025764841 scopus 로고
    • The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice
    • Van den Eynde, B. The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice. Journal of Experimental Medicine 173, 1373-1384 (1991)
    • (1991) Journal of Experimental Medicine , vol.173 , pp. 1373-1384
    • Van Den Eynde, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.