Paradoxical activation of T cells via augmented ERK signaling mediated by a RAF inhibitor

Cancer immunology research

Volumn 2, Issue 1, 2014, Pages 70-79

  Callahan, Margaret K ^a   Masters, Gregg ^a   Pratilas, Christine A ^a   Ariyan, Charlotte ^a   Katz, Jessica ^a   Kitano, Shigehisa ^a   Russell, Valerie ^a   Gordon, Ruth A nn ^a   Vyas, Shachi ^a   Yuan, Jianda ^a   Gupta, Ashok ^a   Wigginton, Jon M ^a   Rosen, Neal ^a   Merghoub, Taha ^a   Jure Kunkel, Maria ^a   Wolchok, Jedd D ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

BRAF; CTLA 4; immunotherapy; Melanoma; RAF inhibitors; T cell

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; CARBAMIC ACID DERIVATIVE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; EPITOPE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR; RAF PROTEIN; XL 281;

ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; DRUG SCREENING; FEMALE; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; BENZIMIDAZOLES; CARBAMATES; CELL LINE; CTLA-4 ANTIGEN; EPITOPES, T-LYMPHOCYTE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; LYMPHOCYTE ACTIVATION; MAP KINASE SIGNALING SYSTEM; MICE; PROTEIN KINASE INHIBITORS; RAF KINASES; T-LYMPHOCYTE SUBSETS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84902596389     PISSN: None     EISSN: 23266074     Source Type: Journal    
DOI: 10.1158/2326-6066.CIR-13-0160     Document Type: Article

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