Human peripheral γ;δ; T cells possess regulatory potential

Immunology

Volumn 128, Issue 4, 2009, Pages 580-588

  Kühl, Anja A ^a,b   Pawlowski, Nina N ^a,b   Grollich, Katja ^a,b   Blessenohl, Maike ^c   Westermann, Jürgen ^c   Zeitz, Martin ^a   Loddenkemper, Christoph ^b,d   Hoffmann, Jörg C ^a,b  

^a Med Klinik I   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c IMMATICS BIOTECHNOLOGIES GMBH   (Germany)

^d UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Anergy; Cytokines; Regulatory T cells; Suppression; Transforming growth factor

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; LATENCY ASSOCIATED PEPTIDE; MESSENGER RNA; THYMIDINE DERIVATIVE; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; AUTACOID; CYTOKINE; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ISOLATION; CELL LEVEL; CELL MATURATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GAMMA DELTA T LYMPHOCYTE; GENE EXPRESSION PROFILING; GROWTH INHIBITION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; IN VITRO STUDY; MALE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CELL CULTURE; CLONAL ANERGY; COCULTURE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; REGULATORY T LYMPHOCYTE;

CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; CLONAL ANERGY; COCULTURE TECHNIQUES; CYTOKINES; HUMANS; INFLAMMATION MEDIATORS; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 70449344594     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03162.x     Document Type: Article

References (41)

1. Kaufmann SH, Blum C, Yamamoto S. Crosstalk between αβ T cells and γδ T cells in vivo: activation of αβ T-cell responses after γδ T-cell modulation with the monoclonal antibody GL3. Proc Natl Acad Sci USA 1993 90 : 9620 9624.
2. Pennington DJ, Silva-Santos B, Shires J et al. The inter-relatedness and interdependence of mouse T cell receptor γδ + and αβ + cells. Nat Immunol 2003 4 : 991 998.
3. Roberts SJ, Smith AL, West AB, Wen L, Findly RC, Owen MJ, Hayday AC. T-cell αβ + and γδ + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc Natl Acad Sci USA 1996 93 : 11774 11779.
4. King DP, Hyde DM, Jackson KA et al. Cutting edge: protective response to pulmonary injury requires γδ T lymphocytes. J Immunol 1999 162 : 5033 5036.
5. Hoffmann JC, Peters K, Henschke S, Herrmann B, Pfister K, Westermann J, Zeitz M. Role of T lymphocytes in rat 2,4,6-trinitrobenzene sulphonic acid (TNBS) induced colitis: increased mortality after γδ T cell depletion and no effect of alphabeta T cell depletion. Gut 2001 48 : 489 495.
6. Chen Y, Chou K, Fuchs E, Havran WL, Boismenu R. Protection of the intestinal mucosa by intraepithelial γδ T cells. Proc Natl Acad Sci USA 2002 99 : 14338 14343.
7. Kühl AA, Loddenkemper C, Westermann J, Hoffmann JC. Role of γδ T cells in inflammatory bowel disease. Pathobiology 2002 70 : 150 155.
8. Tsuchiya T, Fukuda S, Hamada H, Nakamura A, Kohama Y, Ishikawa H, Tsujikawa K, Yamamoto H. Role of γδ T cells in the inflammatory response of experimental colitis mice. J Immunol 2003 171 : 5507 5513.
9. Inagaki-Ohara K, Chinen T, Matsuzaki G et al. Mucosal T cells bearing TCR γδ play a protective role in intestinal inflammation. J Immunol 2004 173 : 1390 1398.
10. Harrison LC, Dempsey-Collier M, Kramer DR, Takahashi K. Aerosol insulin induces regulatory CD8 γδ T cells that prevent murine insulin-dependent diabetes. J Exp Med 1996 184 : 2167 2174.
11. Locke NR, Stankovic S, Funda DP, Harrison LC. TCR γδ intraepithelial lymphocytes are required for self-tolerance. J Immunol 2006 176 : 6553 6559.
12. Gao Y, Yang W, Pan M, Scully E, Girardi M, Augenlicht LH, Craft J, Yin Z. γδ T cells provide an early source of interferon gamma in tumor immunity. J Exp Med 2003 198 : 433 442.
13. Girardi M, Glusac E, Filler RB, Roberts SJ, Propperova I, Lewis J, Tigelaar RE, Hayday AC. The distinct contributions of murine T cell receptor (TCR) γδ + and TCR αβ + T cells to different stages of chemically induced skin cancer. J Exp Med 2003 198 : 747 755.
14. Haas W, Pereira P, Tonegawa S. γδ cells. Annu Rev Immunol 1993 11 : 637 685.
15. Boismenu R, Havran WL. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 1994 266 : 1253 1255.
16. Havran WL. A role for epithelial γδ T cells in tissue repair. Immunol Res 2000 3 : 63 9.
17. Havran WL, Jameson JM, Witherden DA. Epithelial cells and their neighbors. III. Interactions between intraepithelial lymphocytes and neighboring epithelial cells. Am J Physiol Gastrointest Liver Physiol 2005 289 : G627 30.
18. Komori HK, Meehan TF, Havran WL. Epithelial and mucosal γδ T cells. Curr Opin Immunol 2006 18 : 534 538.
19. Kuhl AA, Pawlowski NN, Grollich K, Loddenkemper C, Zeitz M, Hoffmann JC. Aggravation of intestinal inflammation by depletion-deficiency of γδ T cells in different types of IBD animal models. J Leukoc Biol 2007 81 : 168 175.
20. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001 25 : 402 408.
21. Deusch K, Luling F, Reich K, Classen M, Wagner H, Pfeffer K. A major fraction of human intraepithelial lymphocytes simultaneously expresses the γδ T cell receptor, the CD8 accessory molecule and preferentially uses the Vδ1 gene segment. Eur J Immunol 1991 21 : 1053 1059.
22. + suppressor T cells: more questions than answers. Nat Rev Immunol 2002 2 : 389 400.
23. + regulatory T cells. J Immunol 2004 172 : 5986 5993.
24. (high) T cells in inflammatory bowel disease. Gastroenterology 2005 128 : 1868 1878.
25. + T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001 193 : 1285 1294.
26. + regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]. J Exp Med 2002 196 : 247 253.
27. + intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J Clin Invest 2008 118 : 281 293.
28. Peng G, Wang HY, Peng W, Kiniwa Y, Seo KH, Wang RF. Tumor-infiltrating γδ T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway. Immunity 2007 27 : 334 348.
29. + natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006 212 : 8 27.
30. + T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3. J Immunol 2006 177 : 7820 7832.
31. + regulatory T cells. J Immunol 2006 177 : 7634 7644. (Pubitemid 44846278)
32. Wu H, Knight JF, Alexander SI. Regulatory gamma delta T cells in Heymann nephritis express an invariant Vγ6-Vδ1 with a canonical CDR3 sequence. Eur J Immunol 2004 34 : 2322 2330.
33. Hahm KB, Im YH, Parks TW, Park SH, Markowitz S, Jung HY, Green J, Kim SJ. Loss of transforming growth factor β signalling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 2001 49 : 190 198.
34. Beck PL, Rosenberg IM, Xavier RJ, Koh T, Wong JF, Podolsky DK. Transforming growth factor-β mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am J Pathol 2003 162 : 597 608.
35. Mammen JM, Matthews JB. Mucosal repair in the gastrointestinal tract. Crit Care Med 2003 8 (Suppl S532 7.
36. Dignass AU. Mechanisms and modulation of intestinal epithelial repair. Inflamm Bowel Dis 2001 7 : 68 77.
37. Babyatsky MW, Rossiter G, Podolsky DK. Expression of transforming growth factors α and β in colonic mucosa in inflammatory bowel disease. Gastroenterology 1996 110 : 975 984.
38. Thompson JS, Saxena SK, Sharp JG. Regulation of intestinal regeneration: new insights. Microsc Res Tech 2000 51 : 129 137.
39. Fuss IJ, Boirivant M, Lacy B, Strober W. The interrelated roles of TGF-γδ and IL-10 in the regulation of experimental colitis. J Immunol 2002 168 : 900 908.
40. Lopez RD. Human γδ-T cells in adoptive immunotherapy of malignant and infectious diseases. Immunol Res 2002 3 : 207 221.
41. Ferrarini M, Ferrero E, Dagna L, Poggi A, Zocchi MR. Human γδ T cells: a nonredundant system in the immune-surveillance against cancer. Trends Immunol 2002 23 : 14 8.