Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model

Oncotarget

Volumn 7, Issue 23, 2016, Pages 34341-34355

  Suarez, Eloah Rabello ^a,b,c   Chang, De Kuan ^a,b   Sun, Jiusong ^a,b   Sui, Jianhua ^d   Freeman, Gordon J ^a,b   Signoretti, Sabina ^e   Zhu, Quan ^a,b   Marasco, Wayne A ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c FACULDADE DE MEDICINA DO ABC   (Brazil)

^d NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Carbonic anhydrase IX; Chimeric antigen receptor; Immune checkpoint inhibitor; Interleukin 21; T cell exhaustion

Indexed keywords

CARBONATE DEHYDRATASE IX; GAMMA INTERFERON; GRANZYME B; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G4 ANTIBODY; INTERLEUKIN 2; KI 67 ANTIGEN; LENTIVIRUS VECTOR; PROGRAMMED DEATH 1 LIGAND 1; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; ANTIBODY; CARBONATE DEHYDRATASE; CD274 PROTEIN, HUMAN; GRANZYME; GZMB PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; MKI67 PROTEIN, MOUSE; TUMOR ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY SECRETING CELL; ARTICLE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CD8+ T LYMPHOCYTE; CELL ENGINEERING; CELL KILLING; CELL THERAPY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; NORMAL HUMAN; PROTEIN EXPRESSION; THERAPY EFFECT; TUMOR VOLUME; UPREGULATION; ANIMAL; BIOSYNTHESIS; CHIMERA; DISEASE MODEL; HEK293 CELL LINE; IMMUNOLOGY; IMMUNOTHERAPY; KIDNEY TUMOR; LYMPHOCYTE SUBPOPULATION; METABOLISM; PROCEDURES; RENAL CELL CARCINOMA; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CELL LINE;

ANIMALS; ANTIBODIES; ANTIGENS, NEOPLASM; B7-H1 ANTIGEN; CARBONIC ANHYDRASES; CARCINOMA, RENAL CELL; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CHIMERA; DISEASE MODELS, ANIMAL; GRANZYMES; HEK293 CELLS; HUMANS; IMMUNOTHERAPY; KI-67 ANTIGEN; KIDNEY NEOPLASMS; KILLER CELLS, NATURAL; LYMPHOCYTE SUBSETS; LYMPHOCYTES, TUMOR-INFILTRATING; MICE; RECEPTORS, ANTIGEN, T-CELL;

EID: 84973640899     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.9114     Document Type: Article

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