Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

Journal of Experimental Medicine

Volumn 211, Issue 9, 2014, Pages 1905-1918

  Penaloza MacMaster, Pablo ^a   Kamphorst, Alice O ^a   Wieland, Andreas ^a   Araki, Koichi ^a   Iyer, Smita S ^a   West, Erin E ^a   O'Mara, Leigh ^a   Yang, Shu ^a,b   Konieczny, Bogumila T ^a   Sharpe, Arlene H ^c   Freeman, Gordon J ^c   Rudensky, Alexander Y ^d,e   Ahmed, Rafi ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Central South University   (China)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; PROGRAMMED DEATH 1 RECEPTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARENAVIRUS INFECTION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; EXHAUSTION; IMMUNOMODULATION; INFECTION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; LYMPHOCYTOTOXICITY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PERSISTENT INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T CELL DEPLETION; T CELL EXHAUSTION; T LYMPHOCYTE ACTIVATION; UPREGULATION; VIRAL CLEARANCE; VIRUS IMMUNITY; VIRUS LOAD;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; DENDRITIC CELLS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROGRAMMED CELL DEATH 1 RECEPTOR; T-LYMPHOCYTES, REGULATORY; UP-REGULATION;

EID: 84906536054     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20132577     Document Type: Article

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