메뉴 건너뛰기




Volumn 14, Issue 8, 2015, Pages 561-584

Combination cancer immunotherapy and new immunomodulatory targets

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ATEZOLIZUMAB; B RAF KINASE INHIBITOR; B7 ANTIGEN; BEVACIZUMAB; CD134 ANTIGEN; CD137 ANTIGEN; CD27 ANTIGEN; CD40 ANTIGEN; DABRAFENIB; DACARBAZINE; DEATH RECEPTOR 3; DURVALUMAB; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; HERPESVIRUS ENTRY MEDIATOR; IMMUNOGLOBULIN; IPILIMUMAB; NIVOLUMAB; PAZOPANIB; PF 05082566; PROTEIN LAG3; RITUXIMAB; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN; SUNITINIB; TRAMETINIB; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG; URELUMAB; VASCULOTROPIN RECEPTOR; VEMURAFENIB; CD274 PROTEIN, HUMAN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR;

EID: 84938350452     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4591     Document Type: Review
Times cited : (1068)

References (270)
  • 1
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
    • Schreiber, R. D., Old, L. J. & Smyth, M. J. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331, 1565- 1570 (2011).
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 2
    • 84990011361 scopus 로고    scopus 로고
    • HLA-binding properties of tumor neoepitopes in humans
    • Fritsch, E. F. et al. HLA-binding properties of tumor neoepitopes in humans. Cancer Immunol. Res. 2, 522-529 (2014).
    • (2014) Cancer Immunol. Res , vol.2 , pp. 522-529
    • Fritsch, E.F.1
  • 3
    • 84920921528 scopus 로고    scopus 로고
    • Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
    • Gubin, M. M. et al. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515, 577-581 (2014).
    • (2014) Nature , vol.515 , pp. 577-581
    • Gubin, M.M.1
  • 4
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD 1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman, G. J. et al. Engagement of the PD 1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027-1034 (2000).
    • (2000) J. Exp. Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1
  • 5
    • 57849168934 scopus 로고    scopus 로고
    • Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    • Blackburn, S. D. et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 10, 29-37 (2009).
    • (2009) Nat. Immunol , vol.10 , pp. 29-37
    • Blackburn, S.D.1
  • 6
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi, F. S. et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010).
    • (2010) N. Engl. J. Med , vol.363 , pp. 711-723
    • Hodi, F.S.1
  • 7
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti PD L1) treatment leads to clinical activity in metastatic bladder cancer
    • Powles, T. et al. MPDL3280A (anti PD L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 515, 558-562 (2014).
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1
  • 8
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti PD 1) in melanoma
    • Hamid, O. et al. Safety and tumor responses with lambrolizumab (anti PD 1) in melanoma. N. Engl. J. Med. 369, 134-144 (2013).
    • (2013) N. Engl. J. Med , vol.369 , pp. 134-144
    • Hamid, O.1
  • 9
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death 1 (MDX 1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer, J. R. et al. Phase I study of single-agent anti-programmed death 1 (MDX 1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28, 3167-3175 (2010).
    • (2010) J. Clin. Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1
  • 10
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti PD L1 antibody MPDL3280A in cancer patients
    • Herbst, R. S. et al. Predictive correlates of response to the anti PD L1 antibody MPDL3280A in cancer patients. Nature 515, 563-567 (2014).
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1
  • 11
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • Garon, E. B. et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N. Engl. J. Med. 372, 2018-2028 (2015).
    • (2015) N. Engl. J. Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1
  • 12
    • 84932628341 scopus 로고    scopus 로고
    • PD 1 blockade in tumors with mismatch-repair deficiency
    • Le, D. T. et al. PD 1 blockade in tumors with mismatch-repair deficiency. N. Engl. J. Med. http://dx.doi. org/10.1056/nejmoa1500596 (2015).
    • (2015) N. Engl. J. Med
    • Le, D.T.1
  • 13
    • 84929481481 scopus 로고    scopus 로고
    • Pembrolizumab versus ipilimumab in advanced melanoma
    • Robert, C. et al. Pembrolizumab versus ipilimumab in advanced melanoma. N. Engl. J. Med. http://dx.doi. org/10.1056/nejmoa1503093 (2015).
    • (2015) N. Engl. J. Med
    • Robert, C.1
  • 14
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin, J. et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N. Engl. J. Med. http://dx.doi.org/10.1056/nejmoa1504030 (2015).
    • (2015) N. Engl. J. Med
    • Larkin, J.1
  • 15
    • 84928917822 scopus 로고    scopus 로고
    • Pooled analysis of long-term survival data from Phase II and Phase III trials of ipilimumab in unresectable or metastatic melanoma
    • Schadendorf, D. et al. Pooled analysis of long-term survival data from Phase II and Phase III trials of ipilimumab in unresectable or metastatic melanoma. J. Clin. Oncol. 33, 1889-1894 (2015).
    • (2015) J. Clin. Oncol , vol.33 , pp. 1889-1894
    • Schadendorf, D.1
  • 16
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok, J. D. et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369, 122-133 (2013).
    • (2013) N. Engl. J. Med , vol.369 , pp. 122-133
    • Wolchok, J.D.1
  • 17
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
    • Postow, M. A. et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N. Engl. J. Med. 372, 2006-2017 (2015).
    • (2015) N. Engl. J. Med , vol.372 , pp. 2006-2017
    • Postow, M.A.1
  • 18
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
    • Jenkins, M. K. & Schwartz, R. H. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165, 302-319 (1987).
    • (1987) J. Exp. Med , vol.165 , pp. 302-319
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 19
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a phase 1 trial of the anti CD28 monoclonal antibody TGN1412
    • Suntharalingam, G. et al. Cytokine storm in a phase 1 trial of the anti CD28 monoclonal antibody TGN1412. N. Engl. J. Med. 355, 1018-1028 (2006).
    • (2006) N. Engl. J. Med , vol.355 , pp. 1018-1028
    • Suntharalingam, G.1
  • 20
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (anti PD 1; BMS 936558, ONO 4538) and ipilimumab in first-line NSCLC: Interim phase i results
    • Suppl
    • Antonia, S. J. et al. Nivolumab (anti PD 1; BMS 936558, ONO 4538) and ipilimumab in first-line NSCLC: interim phase I results. J. Clin. Oncol. 32 Suppl., 8023 (2014).
    • (2014) J. Clin. Oncol , vol.32 , Issue.8023
    • Antonia, S.J.1
  • 21
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (anti PD 1; BMS 936558, ONO 4538) in combination with platinum-based doublet chemotherapy (PT DC) in advanced non-small cell lung cancer (NSCLC
    • Suppl
    • Antonia, S. J. et al. Nivolumab (anti PD 1; BMS 936558, ONO 4538) in combination with platinum-based doublet chemotherapy (PT DC) in advanced non-small cell lung cancer (NSCLC). J. Clin. Oncol. 32 Suppl., 8113 (2014).
    • (2014) J. Clin. Oncol , vol.32 , Issue.8113
    • Antonia, S.J.1
  • 22
    • 84914176528 scopus 로고    scopus 로고
    • Nivolumab (anti PD 1; BMS 936558, ONO 4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC
    • Suppl
    • Amin, A. et al. Nivolumab (anti PD 1; BMS 936558, ONO 4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. 32 Suppl., 5010 (2014).
    • (2014) J. Clin. Oncol , vol.32 , Issue.5010
    • Amin, A.1
  • 23
    • 84914148032 scopus 로고    scopus 로고
    • Phase i study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC
    • Suppl.
    • Hammers, H. et al. Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. 32 Suppl., 4504 (2014).
    • (2014) J. Clin. Oncol , vol.32 , Issue.4504
    • Hammers, H.1
  • 24
    • 84880277245 scopus 로고    scopus 로고
    • Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD L1 antibody in patients with locally advanced or metastatic melanoma (mM
    • Suppl.
    • Hamid, O. S. et al. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD L1 antibody in patients with locally advanced or metastatic melanoma (mM). J. Clin. Oncol. 31 Suppl., 9010 (2013).
    • (2013) J. Clin. Oncol , vol.31 , Issue.9010
    • Hamid, O.S.1
  • 25
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • Postow, M. A. et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N. Engl. J. Med. 366, 925-931 (2012).
    • (2012) N. Engl. J. Med , vol.366 , pp. 925-931
    • Postow, M.A.1
  • 26
    • 84938309673 scopus 로고    scopus 로고
    • Phase Ib study of MEDI4736, a programmed cell death ligand 1 (PD L1) antibody, in combination with tremelimumab, a cytotoxic T lymphocyte-associated protein 4 (CTLA 4) antibody, in patients (pts) with advanced NSCLC
    • Suppl.
    • Antonia, S. et al. Phase Ib study of MEDI4736, a programmed cell death ligand 1 (PD L1) antibody, in combination with tremelimumab, a cytotoxic T lymphocyte-associated protein 4 (CTLA 4) antibody, in patients (pts) with advanced NSCLC. J. Clin. Oncol. 33 Suppl., 3014 (2015
    • (2015) J. Clin. Oncol , vol.33 , Issue.3014
    • Antonia, S.1
  • 27
    • 27144496045 scopus 로고    scopus 로고
    • CTLA 4 and PD 1 receptors inhibit T cell activation by distinct mechanisms
    • Parry, R. V. et al. CTLA 4 and PD 1 receptors inhibit T cell activation by distinct mechanisms. Mol. Cell. Biol. 25, 9543-9553 (2005).
    • (2005) Mol. Cell. Biol , vol.25 , pp. 9543-9553
    • Parry, R.V.1
  • 28
    • 84886583217 scopus 로고    scopus 로고
    • Activity of anti PD 1 in murine tumor models: Role of host PD L1 and synergistic effect of anti PD 1 and anti-CTLA 4
    • Suppl.
    • Korman, A. et al. Activity of anti PD 1 in murine tumor models: role of "host" PD L1 and synergistic effect of anti PD 1 and anti-CTLA 4. J. Immunol. 178 Suppl., S82 (2007).
    • (2007) J. Immunol , vol.178 , pp. S82
    • Korman, A.1
  • 29
    • 84855940380 scopus 로고    scopus 로고
    • A new therapeutic strategy for malaria: Targeting T cell exhaustion
    • Freeman, G. J. & Sharpe, A. H. A new therapeutic strategy for malaria: targeting T cell exhaustion. Nat. Immunol. 13, 113-115 (2012).
    • (2012) Nat. Immunol , vol.13 , pp. 113-115
    • Freeman, G.J.1    Sharpe, A.H.2
  • 30
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • Robert, C. et al. Nivolumab in previously untreated melanoma without BRAF mutation. N. Engl. J. Med. 372, 320-330 (2015).
    • (2015) N. Engl. J. Med , vol.372 , pp. 320-330
    • Robert, C.1
  • 31
    • 84907486895 scopus 로고    scopus 로고
    • Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD L1 blockade
    • Dovedi, S. J. et al. Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD L1 blockade. Cancer Res. 74, 5458-5468 (2014).
    • (2014) Cancer Res , vol.74 , pp. 5458-5468
    • Dovedi, S.J.1
  • 33
    • 84903814426 scopus 로고    scopus 로고
    • Pharmacodynamic effect of ipilimumab on absolute lymphocyte count (ALC) and association with overall survival in patients with advanced melanoma
    • Suppl.
    • Postow, M. A. et al. Pharmacodynamic effect of ipilimumab on absolute lymphocyte count (ALC) and association with overall survival in patients with advanced melanoma. J. Clin. Oncol. 31 Suppl., 9052 (2013).
    • (2013) J. Clin. Oncol , vol.31 , Issue.9052
    • Postow, M.A.1
  • 34
    • 84863924314 scopus 로고    scopus 로고
    • Regulatory T cell modulation using cyclophosphamide in vaccine approaches: A current perspective
    • Le, D. T. & Jaffee, E. M. Regulatory T cell modulation using cyclophosphamide in vaccine approaches: a current perspective. Cancer Res. 72, 3439-3444 (2012).
    • (2012) Cancer Res , vol.72 , pp. 3439-3444
    • Le, D.T.1    Jaffee, E.M.2
  • 35
    • 77951086882 scopus 로고    scopus 로고
    • 5 Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity
    • Vincent, J. et al. 5 Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity. Cancer Res. 70, 3052-3061 (2010).
    • (2010) Cancer Res , vol.70 , pp. 3052-3061
    • Vincent, J.1
  • 36
    • 84874232680 scopus 로고    scopus 로고
    • Antitumor effect of paclitaxel is mediated by inhibition of myeloid-derived suppressor cells and chronic inflammation in the spontaneous melanoma model
    • Sevko, A. et al. Antitumor effect of paclitaxel is mediated by inhibition of myeloid-derived suppressor cells and chronic inflammation in the spontaneous melanoma model. J. Immunol. 190, 2464-2471 (2013).
    • (2013) J. Immunol , vol.190 , pp. 2464-2471
    • Sevko, A.1
  • 37
    • 80053353709 scopus 로고    scopus 로고
    • Prerequisites for the antitumor vaccine-like effect of chemotherapy and radiotherapy
    • Hannani, D. et al. Prerequisites for the antitumor vaccine-like effect of chemotherapy and radiotherapy. Cancer J. 17, 351-358 (2011).
    • (2011) Cancer J. , vol.17 , pp. 351-358
    • Hannani, D.1
  • 38
    • 84905994658 scopus 로고    scopus 로고
    • Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
    • Kim, K. et al. Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells. Proc. Natl Acad. Sci. USA 111, 11774-11779 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 11774-11779
    • Kim, K.1
  • 39
    • 0023038364 scopus 로고
    • Effect of corticosteroid on the antitumor activity of lymphokine-activated killer cells and interleukin 2 in mice
    • Papa, M. Z., Vetto, J. T., Ettinghausen, S. E., Mule, J. J. & Rosenberg, S. A. Effect of corticosteroid on the antitumor activity of lymphokine-activated killer cells and interleukin 2 in mice. Cancer Res. 46, 5618-5623 (1986).
    • (1986) Cancer Res , vol.46 , pp. 5618-5623
    • Papa, M.Z.1    Vetto, J.T.2    Ettinghausen, S.E.3    Mule, J.J.4    Rosenberg, S.A.5
  • 40
    • 0025250697 scopus 로고
    • Inhibition of interleukin 2 induced tumor necrosis factor release by dexamethasone: Prevention of an acquired neutrophil chemotaxis defect and differential suppression of interleukin 2 associated side effects
    • Mier, J. W. et al. Inhibition of interleukin 2 induced tumor necrosis factor release by dexamethasone: prevention of an acquired neutrophil chemotaxis defect and differential suppression of interleukin 2 associated side effects. Blood 76, 1933-1940 (1990).
    • (1990) Blood , vol.76 , pp. 1933-1940
    • Mier, J.W.1
  • 41
    • 0023134875 scopus 로고
    • Reduction of toxicity of interleukin 2 and lymphokine-activated killer cells in humans by the administration of corticosteroids
    • Vetto, J. T., Papa, M. Z., Lotze, M. T., Chang, A. E. & Rosenberg, S. A. Reduction of toxicity of interleukin 2 and lymphokine-activated killer cells in humans by the administration of corticosteroids. J. Clin. Oncol. 5, 496-503 (1987).
    • (1987) J. Clin. Oncol , vol.5 , pp. 496-503
    • Vetto, J.T.1    Papa, M.Z.2    Lotze, M.T.3    Chang, A.E.4    Rosenberg, S.A.5
  • 42
    • 84933554760 scopus 로고    scopus 로고
    • Efficacy and safety results from a Phase III trial of nivolumab (NIVO) alone or combined with ipilimumab (IPI) versus IPI alone in treatment-naive patients (pts) with advanced melanoma (MEL) (CheckMate 067
    • Suppl., LBA1
    • Wolchok, J. et al. Efficacy and safety results from a Phase III trial of nivolumab (NIVO) alone or combined with ipilimumab (IPI) versus IPI alone in treatment-naive patients (pts) with advanced melanoma (MEL) (CheckMate 067). J. Clin. Oncol. 33 Suppl., LBA1 (2015).
    • (2015) J. Clin. Oncol , vol.33
    • Wolchok, J.1
  • 43
    • 84883008576 scopus 로고    scopus 로고
    • BRAF inhibition improves tumor recognition by the immune system: Potential implications for combinatorial therapies against melanoma involving adoptive T cell transfer
    • Donia, M. et al. BRAF inhibition improves tumor recognition by the immune system: potential implications for combinatorial therapies against melanoma involving adoptive T cell transfer. Oncoimmunology 1, 1476-1483 (2012).
    • (2012) Oncoimmunology , vol.1 , pp. 1476-1483
    • Donia, M.1
  • 44
    • 84874872137 scopus 로고    scopus 로고
    • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma
    • Frederick, D. T. et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin. Cancer Res. 19, 1225-1231 (2013).
    • (2013) Clin. Cancer Res , vol.19 , pp. 1225-1231
    • Frederick, D.T.1
  • 45
    • 84873336707 scopus 로고    scopus 로고
    • The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD L1 expression that is reversible by MEK and PI3K inhibition
    • Jiang, X., Zhou, J., Giobbie-Hurder, A., Wargo, J. & Hodi, F. S. The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD L1 expression that is reversible by MEK and PI3K inhibition. Clin. Cancer Res. 19, 598-609 (2013).
    • (2013) Clin. Cancer Res , vol.19 , pp. 598-609
    • Jiang, X.1    Zhou, J.2    Giobbie-Hurder, A.3    Wargo, J.4    Hodi, F.S.5
  • 46
    • 84964313375 scopus 로고    scopus 로고
    • Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade
    • Cooper, Z. A. et al. Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade. Cancer Immunol. Res. 2, 643- 654 (2014).
    • (2014) Cancer Immunol. Res , vol.2 , pp. 643-654
    • Cooper, Z.A.1
  • 47
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of vemurafenib and ipilimumab
    • Ribas, A., Hodi, F. S., Callahan, M., Konto, C. & Wolchok, J. Hepatotoxicity with combination of vemurafenib and ipilimumab. N. Engl. J. Med. 368, 1365-1366 (2013).
    • (2013) N. Engl. J. Med , vol.368 , pp. 1365-1366
    • Ribas, A.1    Hodi, F.S.2    Callahan, M.3    Konto, C.4    Wolchok, J.5
  • 48
    • 84936821507 scopus 로고    scopus 로고
    • Phase i study combining anti PD L1 (MEDI4736) with BRAF (dabrafenib) and/or MEK (trametinib) inhibitors in advanced melanoma
    • Suppl.
    • Ribas, A. et al. Phase I study combining anti PD L1 (MEDI4736) with BRAF (dabrafenib) and/or MEK (trametinib) inhibitors in advanced melanoma. J. Clin. Oncol. 33 Suppl., 3003 (2015).
    • (2015) J. Clin. Oncol , vol.33 , Issue.3003
    • Ribas, A.1
  • 49
    • 84884556145 scopus 로고    scopus 로고
    • History of myeloid-derived suppressor cells
    • Talmadge, J. E. & Gabrilovich, D. I. History of myeloid-derived suppressor cells. Nat. Rev. Cancer 13, 739-752 (2013).
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 739-752
    • Talmadge, J.E.1    Gabrilovich, D.I.2
  • 50
    • 79958052123 scopus 로고    scopus 로고
    • MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy
    • Finke, J. et al. MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy. Int. Immunopharmacol. 11, 856-861 (2011).
    • (2011) Int. Immunopharmacol , vol.11 , pp. 856-861
    • Finke, J.1
  • 51
    • 77958072683 scopus 로고    scopus 로고
    • Renal cancer resistance to antiangiogenic therapy is delayed by restoration of angiostatic signaling
    • Bhatt, R. S. et al. Renal cancer resistance to antiangiogenic therapy is delayed by restoration of angiostatic signaling. Mol. Cancer Ther. 9, 2793-2802 (2010).
    • (2010) Mol. Cancer Ther , vol.9 , pp. 2793-2802
    • Bhatt, R.S.1
  • 52
    • 0034548821 scopus 로고    scopus 로고
    • Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non- Hodgkin lymphoma: A single-institution study of 200 patients
    • Salven, P., Orpana, A., Teerenhovi, L. & Joensuu, H. Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non- Hodgkin lymphoma: a single-institution study of 200 patients. Blood 96, 3712-3718 (2000).
    • (2000) Blood , vol.96 , pp. 3712-3718
    • Salven, P.1    Orpana, A.2    Teerenhovi, L.3    Joensuu, H.4
  • 53
    • 84893792927 scopus 로고    scopus 로고
    • Serum VEGF level is associated with the outcome of patients with hepatocellular carcinoma: A meta-analysis
    • Zhan, P., Qian, Q. & Yu, L. K. Serum VEGF level is associated with the outcome of patients with hepatocellular carcinoma: a meta-analysis. Hepatobiliary Surg. Nutr. 2, 209-215 (2013).
    • (2013) Hepatobiliary Surg. Nutr , vol.2 , pp. 209-215
    • Zhan, P.1    Qian, Q.2    Yu, L.K.3
  • 54
    • 84996525854 scopus 로고    scopus 로고
    • Pretreatment serum VEGF is associated with clinical response and overall survival in advanced melanoma patients treated with ipilimumab
    • Yuan, J. et al. Pretreatment serum VEGF is associated with clinical response and overall survival in advanced melanoma patients treated with ipilimumab. Cancer Immunol. Res. 2, 127-132 (2014).
    • (2014) Cancer Immunol. Res , vol.2 , pp. 127-132
    • Yuan, J.1
  • 55
    • 0034984740 scopus 로고    scopus 로고
    • VEGF as a mediator of tumor-associated immunodeficiency
    • Ohm, J. E. & Carbone, D. P. VEGF as a mediator of tumor-associated immunodeficiency. Immunol. Res. 23, 263-272 (2001).
    • (2001) Immunol. Res , vol.23 , pp. 263-272
    • Ohm, J.E.1    Carbone, D.P.2
  • 56
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • Gabrilovich, D. I., Ishida, T., Nadaf, S., Ohm, J. E. & Carbone, D. P. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin. Cancer Res. 5, 2963-2970 (1999).
    • (1999) Clin. Cancer Res , vol.5 , pp. 2963-2970
    • Gabrilovich, D.I.1    Ishida, T.2    Nadaf, S.3    Ohm, J.E.4    Carbone, D.P.5
  • 57
    • 84938313517 scopus 로고    scopus 로고
    • Safety and efficacy of MPDL3280A (anti PDL1) in combination with bevacizumab (bev) and/or chemotherapy (chemo) in patients (pts) with locally advanced or metastatic solid tumors
    • Lieu, C. et al. Safety and efficacy of MPDL3280A (anti PDL1) in combination with bevacizumab (bev) and/or chemotherapy (chemo) in patients (pts) with locally advanced or metastatic solid tumors. Ann. Oncol. 25 (Suppl. 4): iv361-iv372 (2014).
    • (2014) Ann. Oncol , vol.25 , pp. iv361-iv372
    • Lieu, C.1
  • 58
    • 33745063095 scopus 로고    scopus 로고
    • The role of neuropilins in cancer
    • Ellis, L. M. The role of neuropilins in cancer. Mol. Cancer Ther. 5, 1099-1107 (2006).
    • (2006) Mol. Cancer Ther , vol.5 , pp. 1099-1107
    • Ellis, L.M.1
  • 60
    • 84867899675 scopus 로고    scopus 로고
    • T cells: Neuropilin 1 - Distinguishing TReg cell subsets
    • Papatriantafyllou, M. T cells: neuropilin 1 - distinguishing TReg cell subsets. Nat. Rev. Immunol. 12, 746 (2012).
    • (2012) Nat. Rev. Immunol , vol.12 , Issue.746
    • Papatriantafyllou, M.1
  • 62
    • 84904569660 scopus 로고    scopus 로고
    • A Phase i study of the human monoclonal anti NRP1 antibody MNRP1685A in patients with advanced solid tumors
    • Weekes, C. D. et al. A Phase I study of the human monoclonal anti NRP1 antibody MNRP1685A in patients with advanced solid tumors. Invest. New Drugs 32, 653-660 (2014).
    • (2014) Invest. New Drugs , vol.32 , pp. 653-660
    • Weekes, C.D.1
  • 63
    • 84900798650 scopus 로고    scopus 로고
    • Phase Ib study evaluating MNRP1685A, a fully human anti NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors
    • Patnaik, A. et al. Phase Ib study evaluating MNRP1685A, a fully human anti NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors. Cancer Chemother. Pharmacol. 73, 951-960 (2014).
    • (2014) Cancer Chemother. Pharmacol , vol.73 , pp. 951-960
    • Patnaik, A.1
  • 64
    • 84884206864 scopus 로고    scopus 로고
    • Stability and function of regulatory T cells is maintained by a neuropilin 1 semaphorin 4a axis
    • Delgoffe, G. M. et al. Stability and function of regulatory T cells is maintained by a neuropilin 1 semaphorin 4a axis. Nature 501, 252-256 (2013).
    • (2013) Nature , vol.501 , pp. 252-256
    • Delgoffe, G.M.1
  • 65
    • 1942453342 scopus 로고    scopus 로고
    • Historical review: Cytokines as therapeutics and targets of therapeutics
    • Vilcek, J. & Feldmann, M. Historical review: cytokines as therapeutics and targets of therapeutics. Trends Pharmacol. Sci. 25, 201-209 (2004).
    • (2004) Trends Pharmacol. Sci , vol.25 , pp. 201-209
    • Vilcek, J.1    Feldmann, M.2
  • 66
    • 84977100956 scopus 로고    scopus 로고
    • Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy
    • Schaer, D. A., Hirschhorn-Cymerman, D. & Wolchok, J. D. Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy. J. Immunother. Cancer 2, 7 (2014).
    • (2014) J. Immunother. Cancer , vol.2 , Issue.7
    • Schaer, D.A.1    Hirschhorn-Cymerman, D.2    Wolchok, J.D.3
  • 67
    • 0036604470 scopus 로고    scopus 로고
    • Immune responses in 4 1BB (CD137)-deficient mice
    • Kwon, B. S. et al. Immune responses in 4 1BB (CD137)-deficient mice. J. Immunol. 168, 5483-5490 (2002).
    • (2002) J. Immunol , vol.168 , pp. 5483-5490
    • Kwon, B.S.1
  • 68
    • 84938336437 scopus 로고    scopus 로고
    • Biomarker characterization using mass cytometry in a phase 1 trial of urelumab (BMS 663513) in subjects with advanced solid tumors and relapsed/refractory B cell non-Hodgkin lymphoma
    • Suppl.
    • Chester, C. et al. Biomarker characterization using mass cytometry in a phase 1 trial of urelumab (BMS 663513) in subjects with advanced solid tumors and relapsed/refractory B cell non-Hodgkin lymphoma. J. Clin. Oncol. 32 Suppl., 3017 (2014).
    • (2014) J. Clin. Oncol , vol.32 , Issue.3017
    • Chester, C.1
  • 69
    • 84861310650 scopus 로고    scopus 로고
    • Targeted therapy for metastatic melanoma: From bench to bedside
    • Hwu, W. Targeted therapy for metastatic melanoma: from bench to bedside. HemOnc Today [online], http://www.healio.com/hematology-oncology/melanoma-skin-cancer/news/print/hemonc-today/%7B77e71a11- 1fd1-4193-a2f7-7c50c6121c1f%7D/targeted-therapy-for-metastatic-melanoma-from-bench-to-bedside (2010).
    • (2010) HemOnc Today [Online]
    • Hwu, W.1
  • 70
    • 84923303086 scopus 로고    scopus 로고
    • A phase 1 study of PF 05082566 (anti 4 1BB) in patients with advanced cancer
    • Suppl.
    • Segal, N. H. et al. A phase 1 study of PF 05082566 (anti 4 1BB) in patients with advanced cancer. J. Clin. Oncol. 32 Suppl., 3007 (2014).
    • (2014) J. Clin. Oncol , vol.32 , Issue.3007
    • Segal, N.H.1
  • 71
    • 84938353999 scopus 로고    scopus 로고
    • A phase i study of PF 05082566 (anti 4 1BB) + rituximab in patients with CD20+ NHL
    • Suppl.
    • Gopal, A. et al. A phase I study of PF 05082566 (anti 4 1BB) + rituximab in patients with CD20+ NHL. J. Clin. Oncol. 33 Suppl., 3004 (2015).
    • (2015) J. Clin. Oncol , vol.33 , Issue.3004
    • Gopal, A.1
  • 72
    • 84902137525 scopus 로고    scopus 로고
    • Targeting CD137 enhances the efficacy of cetuximab
    • Kohrt, H. E. et al. Targeting CD137 enhances the efficacy of cetuximab. J. Clin. Invest. 124, 2668-2682 (2014).
    • (2014) J. Clin. Invest , vol.124 , pp. 2668-2682
    • Kohrt, H.E.1
  • 73
    • 84892164928 scopus 로고    scopus 로고
    • CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor
    • Ye, Q. et al. CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor. Clin. Cancer Res. 20, 44-55 (2014).
    • (2014) Clin. Cancer Res , vol.20 , pp. 44-55
    • Ye, Q.1
  • 74
    • 84904038862 scopus 로고    scopus 로고
    • OX40 engagement depletes intratumoral Tregs via activating Fc?Rs, leading to antitumor efficacy
    • Bulliard, Y. et al. OX40 engagement depletes intratumoral Tregs via activating Fc?Rs, leading to antitumor efficacy. Immunol. Cell Biol. 92, 475-480 (2014).
    • (2014) Immunol. Cell Biol , vol.92 , pp. 475-480
    • Bulliard, Y.1
  • 75
    • 84897854198 scopus 로고    scopus 로고
    • PD 1 blockade and OX40 triggering synergistically protects against tumor growth in a murine model of ovarian cancer
    • Guo, Z. et al. PD 1 blockade and OX40 triggering synergistically protects against tumor growth in a murine model of ovarian cancer. PLoS ONE 9, e89350 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e89350
    • Guo, Z.1
  • 76
    • 84883853182 scopus 로고    scopus 로고
    • Combined TIM 3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancer
    • Guo, Z. et al. Combined TIM 3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancer. J. Transl. Med. 11, 215 (2013).
    • (2013) J. Transl. Med , vol.11 , Issue.215
    • Guo, Z.1
  • 77
    • 84886945019 scopus 로고    scopus 로고
    • Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co stimulation
    • Adler, A. J. & Vella, A. T. Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co stimulation. Oncoimmunology 2, e22837 (2013).
    • (2013) Oncoimmunology , vol.2 , pp. e22837
    • Adler, A.J.1    Vella, A.T.2
  • 78
    • 84893199565 scopus 로고    scopus 로고
    • Combinatorial PD 1 blockade and CD137 activation has therapeutic efficacy in murine cancer models and synergizes with cisplatin
    • Wei, H. et al. Combinatorial PD 1 blockade and CD137 activation has therapeutic efficacy in murine cancer models and synergizes with cisplatin. PLoS ONE 8, e84927 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e84927
    • Wei, H.1
  • 79
    • 84938305824 scopus 로고    scopus 로고
    • Phase I/II clinical trial of anti OX40, radiation and cyclophosphamide in patients with prostate cancer: Immunological analysis
    • Kovacsovics-Bankowski, M. et al. Phase I/II clinical trial of anti OX40, radiation and cyclophosphamide in patients with prostate cancer: immunological analysis. J. Immunother. Cancer 1, 255 (2013).
    • (2013) J. Immunother. Cancer , vol.1 , Issue.255
    • Kovacsovics-Bankowski, M.1
  • 80
    • 84891275907 scopus 로고    scopus 로고
    • OX40 is a potent immune-stimulating target in late-stage cancer patients
    • Curti, B. D. et al. OX40 is a potent immune-stimulating target in late-stage cancer patients. Cancer Res. 73, 7189-7198 (2013).
    • (2013) Cancer Res , vol.73 , pp. 7189-7198
    • Curti, B.D.1
  • 81
    • 77955279163 scopus 로고    scopus 로고
    • Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation
    • Cohen, A. D. et al. Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation. PLoS ONE 5, e10436 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e10436
    • Cohen, A.D.1
  • 82
    • 84893683548 scopus 로고    scopus 로고
    • Combined PD 1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs
    • Lu, L. et al. Combined PD 1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs. J. Transl. Med. 12, 36 (2014).
    • (2014) J. Transl. Med , vol.12 , Issue.36
    • Lu, L.1
  • 83
    • 41049095846 scopus 로고    scopus 로고
    • CD70 as a therapeutic target in human malignancies
    • Grewal, I. S. CD70 as a therapeutic target in human malignancies. Expert Opin. Ther. Targets 12, 341-351 (2008).
    • (2008) Expert Opin. Ther. Targets , vol.12 , pp. 341-351
    • Grewal, I.S.1
  • 84
    • 84923302520 scopus 로고    scopus 로고
    • Phase i evaluation of an agonist anti CD27 human antibody (CDX 1127) in patients with advanced hematologic malignancies
    • Suppl.
    • Ansell, S. M. et al. Phase I evaluation of an agonist anti CD27 human antibody (CDX 1127) in patients with advanced hematologic malignancies. J. Clin. Oncol. 32 Suppl., 3034 (2014).
    • (2014) J. Clin. Oncol , vol.32 , Issue.3034
    • Ansell, S.M.1
  • 85
    • 84923304533 scopus 로고    scopus 로고
    • Immunologic activity of an activating anti CD27 antibody (CDX 1127) in patients (pts) with solid tumors
    • Suppl.
    • Infante, J. R. et al. Immunologic activity of an activating anti CD27 antibody (CDX 1127) in patients (pts) with solid tumors. J. Clin. Oncol. 32 Suppl., 3027 (2014).
    • (2014) J. Clin. Oncol , vol.32 , Issue.3027
    • Infante, J.R.1
  • 86
    • 84864739127 scopus 로고    scopus 로고
    • The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T cell immunity
    • Twohig, J. P. et al. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T cell immunity. FASEB J. 26, 3575-3586 (2012).
    • (2012) FASEB J. , vol.26 , pp. 3575-3586
    • Twohig, J.P.1
  • 87
    • 33744944082 scopus 로고    scopus 로고
    • Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human
    • Bossen, C. et al. Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J. Biol. Chem. 281, 13964-13971 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 13964-13971
    • Bossen, C.1
  • 88
    • 46749097474 scopus 로고    scopus 로고
    • The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases
    • Meylan, F. et al. The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 29, 79-89 (2008).
    • (2008) Immunity , vol.29 , pp. 79-89
    • Meylan, F.1
  • 89
    • 80052145580 scopus 로고    scopus 로고
    • Triggering of TNFRSF25 promotes CD8+ T cell responses and anti-tumor immunity
    • Slebioda, T. J. et al. Triggering of TNFRSF25 promotes CD8+ T cell responses and anti-tumor immunity. Eur. J. Immunol. 41, 2606-2611 (2011).
    • (2011) Eur. J. Immunol , vol.41 , pp. 2606-2611
    • Slebioda, T.J.1
  • 90
    • 84891495940 scopus 로고    scopus 로고
    • Immunobiology of TNFSF15 and TNFRSF25
    • Schreiber, T. H. & Podack, E. R. Immunobiology of TNFSF15 and TNFRSF25. Immunol. Res. 57, 3-11 (2013).
    • (2013) Immunol. Res , vol.57 , pp. 3-11
    • Schreiber, T.H.1    Podack, E.R.2
  • 91
    • 84866544121 scopus 로고    scopus 로고
    • T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination
    • Schreiber, T. H., Wolf, D., Bodero, M., Gonzalez, L. & Podack, E. R. T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination. J. Immunol. 189, 3311-3318 (2012).
    • (2012) J. Immunol , vol.189 , pp. 3311-3318
    • Schreiber, T.H.1    Wolf, D.2    Bodero, M.3    Gonzalez, L.4    Podack, E.R.5
  • 92
  • 93
    • 84951178450 scopus 로고    scopus 로고
    • Combination of agonistic CD40 monoclonal antibody CP 870 893 and anti-CTLA 4 antibody tremelimumab in patients with metastatic melanoma
    • Bajor, D. et al. Combination of agonistic CD40 monoclonal antibody CP 870, 893 and anti-CTLA 4 antibody tremelimumab in patients with metastatic melanoma. American Association for Cancer Research Annual Meeting [online], http://www.abstractsonline. com/Plan/ViewAbstract.aspx?mID=3682& sKey= b6e2d928-3a12-44b7-9f8a-3a69ffde9741& cKey= b51efb80-7710-4f0e-949b-623213c6ff47& mKey =19573a54-ae8f-4e00-9c23-bd6d62268424 (2015).
    • (2015) American Association for Cancer Research Annual Meeting [Online]
    • Bajor, D.1
  • 94
    • 84938356701 scopus 로고    scopus 로고
    • Induced PD L1 expression mediates acquired resistance to agonistic anti CD40 treatment
    • Zippelius, A., Schreiner, J., Herzig, P. & Muller, P. Induced PD L1 expression mediates acquired resistance to agonistic anti CD40 treatment. Cancer Immunol. Res. 3, 236-244 (2015).
    • (2015) Cancer Immunol. Res , vol.3 , pp. 236-244
    • Zippelius, A.1    Schreiner, J.2    Herzig, P.3    Muller, P.4
  • 95
    • 84930711218 scopus 로고    scopus 로고
    • Systemic agonistic anti CD40 treatment of tumor-bearing mice modulates hepatic myeloid-suppressive cells and causes immune-mediated liver damage
    • Medina-Echeverz, J. et al. Systemic agonistic anti CD40 treatment of tumor-bearing mice modulates hepatic myeloid-suppressive cells and causes immune-mediated liver damage. Cancer Immunol. Res. 3, 557-566 (2015).
    • (2015) Cancer Immunol. Res , vol.3 , pp. 557-566
    • Medina-Echeverz, J.1
  • 96
    • 38349149016 scopus 로고    scopus 로고
    • CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator
    • Cai, G. et al. CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator. Nat. Immunol. 9, 176-185 (2008).
    • (2008) Nat. Immunol , vol.9 , pp. 176-185
    • Cai, G.1
  • 97
    • 74949125667 scopus 로고    scopus 로고
    • BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination
    • Derre, L. et al. BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J. Clin. Invest. 120, 157- 167 (2010).
    • (2010) J. Clin. Invest , vol.120 , pp. 157-167
    • Derre, L.1
  • 98
    • 84876481083 scopus 로고    scopus 로고
    • Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity
    • Pasero, C. & Olive, D. Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity. Immunol. Lett. 151, 71-75 (2013).
    • (2013) Immunol. Lett , vol.151 , pp. 71-75
    • Pasero, C.1    Olive, D.2
  • 99
    • 0037810670 scopus 로고    scopus 로고
    • BTLA is a lymphocyte inhibitory receptor with similarities to CTLA 4 and PD 1
    • Watanabe, N. et al. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA 4 and PD 1. Nat. Immunol. 4, 670-679 (2003).
    • (2003) Nat. Immunol , vol.4 , pp. 670-679
    • Watanabe, N.1
  • 100
    • 5644263642 scopus 로고    scopus 로고
    • Role of LAG 3 in regulatory T cells
    • Huang, C. T. et al. Role of LAG 3 in regulatory T cells. Immunity 21, 503-513 (2004).
    • (2004) Immunity , vol.21 , pp. 503-513
    • Huang, C.T.1
  • 101
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG 3 and PD 1 synergistically regulate T cell function to promote tumoral immune escape
    • Woo, S. R. et al. Immune inhibitory molecules LAG 3 and PD 1 synergistically regulate T cell function to promote tumoral immune escape. Cancer Res. 72, 917-927 (2012).
    • (2012) Cancer Res , vol.72 , pp. 917-927
    • Woo, S.R.1
  • 102
    • 77952343328 scopus 로고    scopus 로고
    • Tumor-infiltrating NY ESO 1 specific CD8+ T cells are negatively regulated by LAG 3 and PD 1 in human ovarian cancer
    • Matsuzaki, J. et al. Tumor-infiltrating NY ESO 1 specific CD8+ T cells are negatively regulated by LAG 3 and PD 1 in human ovarian cancer. Proc. Natl Acad. Sci. USA 107, 7875-7880 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 7875-7880
    • Matsuzaki, J.1
  • 103
    • 84879085032 scopus 로고    scopus 로고
    • A Phase i study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinoma
    • Wang-Gillam, A. et al. A Phase I study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinoma. Invest. New Drugs 31, 707-713 (2013).
    • (2013) Invest. New Drugs , vol.31 , pp. 707-713
    • Wang-Gillam, A.1
  • 104
    • 77955487541 scopus 로고    scopus 로고
    • First-line chemoimmunotherapy in metastatic breast carcinoma: Combination of paclitaxel and IMP321 (LAG 3Ig) enhances immune responses and antitumor activity
    • Brignone, C. et al. First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG 3Ig) enhances immune responses and antitumor activity. J. Transl. Med. 8, 71 (2010).
    • (2010) J. Transl. Med , vol.8 , Issue.71
    • Brignone, C.1
  • 105
    • 70349669259 scopus 로고    scopus 로고
    • A phase i pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma
    • Brignone, C., Escudier, B., Grygar, C., Marcu, M. & Triebel, F. A phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma. Clin. Cancer Res. 15, 6225-6231 (2009).
    • (2009) Clin. Cancer Res , vol.15 , pp. 6225-6231
    • Brignone, C.1    Escudier, B.2    Grygar, C.3    Marcu, M.4    Triebel, F.5
  • 106
    • 0035204919 scopus 로고    scopus 로고
    • Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
    • McIntire, J. J. et al. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat. Immunol. 2, 1109-1116 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 1109-1116
    • McIntire, J.J.1
  • 107
    • 77951673268 scopus 로고    scopus 로고
    • TIM genes: A family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
    • Freeman, G. J., Casasnovas, J. M., Umetsu, D. T. & DeKruyff, R. H. TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol. Rev. 235, 172-189 (2010).
    • (2010) Immunol. Rev , vol.235 , pp. 172-189
    • Freeman, G.J.1    Casasnovas, J.M.2    Umetsu, D.T.3    DeKruyff, R.H.4
  • 108
    • 77957059176 scopus 로고    scopus 로고
    • Cooperation of Tim 3 and PD 1 in CD8 T cell exhaustion during chronic viral infection
    • Jin, H. T. et al. Cooperation of Tim 3 and PD 1 in CD8 T cell exhaustion during chronic viral infection. Proc. Natl Acad. Sci. USA 107, 14733-14738 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 14733-14738
    • Jin, H.T.1
  • 109
    • 77957744369 scopus 로고    scopus 로고
    • Targeting Tim 3 and PD 1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    • Sakuishi, K. et al. Targeting Tim 3 and PD 1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J. Exp. Med. 207, 2187-2194 (2010).
    • (2010) J. Exp. Med , vol.207 , pp. 2187-2194
    • Sakuishi, K.1
  • 110
    • 30044434075 scopus 로고    scopus 로고
    • The Tim 3 ligand galectin 9 negatively regulates T helper type 1 immunity
    • Zhu, C. et al. The Tim 3 ligand galectin 9 negatively regulates T helper type 1 immunity. Nat. Immunol. 6, 1245-1252 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 1245-1252
    • Zhu, C.1
  • 111
    • 84921449533 scopus 로고    scopus 로고
    • CEACAM1 regulates TIM 3 mediated tolerance and exhaustion
    • Huang, Y. H. et al. CEACAM1 regulates TIM 3 mediated tolerance and exhaustion. Nature 517, 386-390 (2015).
    • (2015) Nature , vol.517 , pp. 386-390
    • Huang, Y.H.1
  • 112
    • 77949900365 scopus 로고    scopus 로고
    • T cell/transmembrane Ig and mucin 3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells
    • DeKruyff, R. H. et al. T cell/transmembrane, Ig, and mucin 3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells. J. Immunol. 184, 1918-1930 (2010).
    • (2010) J. Immunol , vol.184 , pp. 1918-1930
    • DeKruyff, R.H.1
  • 114
    • 84903771223 scopus 로고    scopus 로고
    • Galectin 9 controls the therapeutic activity of 4 1BB targeting antibodies
    • Madireddi, S. et al. Galectin 9 controls the therapeutic activity of 4 1BB targeting antibodies. J. Exp. Med. 211, 1433-1448 (2014).
    • (2014) J. Exp. Med , vol.211 , pp. 1433-1448
    • Madireddi, S.1
  • 115
    • 84859192882 scopus 로고    scopus 로고
    • Tim 3 is an inducible human natural killer cell receptor that enhances interferon ? Production in response to galectin 9.
    • Gleason, M. K. et al. Tim 3 is an inducible human natural killer cell receptor that enhances interferon ? production in response to galectin 9. Blood 119, 3064-3072 (2012).
    • (2012) Blood , vol.119 , pp. 3064-3072
    • Gleason, M.K.1
  • 117
    • 84897566999 scopus 로고    scopus 로고
    • Interactions between Siglec 7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance
    • Jandus, C. et al. Interactions between Siglec 7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance. J. Clin. Invest. 124, 1810-1820 (2014).
    • (2014) J. Clin. Invest , vol.124 , pp. 1810-1820
    • Jandus, C.1
  • 118
    • 84907588573 scopus 로고    scopus 로고
    • Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer
    • Laubli, H. et al. Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer. Proc. Natl Acad. Sci. USA 111, 14211-14216 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 14211-14216
    • Laubli, H.1
  • 119
    • 84872001426 scopus 로고    scopus 로고
    • The interaction between Siglec 15 and tumor-associated sialyl Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12 Syk pathway
    • Takamiya, R., Ohtsubo, K., Takamatsu, S., Taniguchi, N. & Angata, T. The interaction between Siglec 15 and tumor-associated sialyl Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12 Syk pathway. Glycobiology 23, 178-187 (2013).
    • (2013) Glycobiology , vol.23 , pp. 178-187
    • Takamiya, R.1    Ohtsubo, K.2    Takamatsu, S.3    Taniguchi, N.4    Angata, T.5
  • 120
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll, D. M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12, 252-264 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 121
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co stimulation and co inhibition
    • Chen, L. & Flies, D. B. Molecular mechanisms of T cell co stimulation and co inhibition. Nat. Rev. Immunol. 13, 227-242 (2013).
    • (2013) Nat. Rev. Immunol , vol.13 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 122
    • 84878990597 scopus 로고    scopus 로고
    • HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T cell function
    • Zhao, R. et al. HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T cell function. Proc. Natl Acad. Sci. USA 110, 9879-9884 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 9879-9884
    • Zhao, R.1
  • 123
    • 65349104572 scopus 로고    scopus 로고
    • Mechanisms of costimulation
    • Sharpe, A. H. Mechanisms of costimulation. Immunol. Rev. 229, 5-11 (2009).
    • (2009) Immunol. Rev , vol.229 , pp. 5-11
    • Sharpe, A.H.1
  • 125
    • 85003055100 scopus 로고    scopus 로고
    • Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti- CTLA 4 therapy
    • Ng Tang, D. et al. Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti- CTLA 4 therapy. Cancer Immunol. Res. 1, 229-234 (2013).
    • (2013) Cancer Immunol. Res , vol.1 , pp. 229-234
    • Ng Tang, D.1
  • 126
    • 84897940775 scopus 로고    scopus 로고
    • Engagement of the ICOS pathway markedly enhances efficacy of CTLA 4 blockade in cancer immunotherapy
    • Fan, X., Quezada, S. A., Sepulveda, M. A., Sharma, P. & Allison, J. P. Engagement of the ICOS pathway markedly enhances efficacy of CTLA 4 blockade in cancer immunotherapy. J. Exp. Med. 211, 715-725 (2014).
    • (2014) J. Exp. Med , vol.211 , pp. 715-725
    • Fan, X.1    Quezada, S.A.2    Sepulveda, M.A.3    Sharma, P.4    Allison, J.P.5
  • 127
    • 84893690007 scopus 로고    scopus 로고
    • Functional clustering of immunoglobulin superfamily proteins with protein-protein interaction information calibrated hidden Markov model sequence profiles
    • Yap, E. H., Rosche, T., Almo, S. & Fiser, A. Functional clustering of immunoglobulin superfamily proteins with protein-protein interaction information calibrated hidden Markov model sequence profiles. J. Mol. Biol. 426, 945-961 (2014).
    • (2014) J. Mol. Biol , vol.426 , pp. 945-961
    • Yap, E.H.1    Rosche, T.2    Almo, S.3    Fiser, A.4
  • 128
    • 84897429090 scopus 로고    scopus 로고
    • VISTA regulates the development of protective antitumor immunity
    • Le Mercier, I. et al. VISTA regulates the development of protective antitumor immunity. Cancer Res. 74, 1933-1944 (2014).
    • (2014) Cancer Res , vol.74 , pp. 1933-1944
    • Le Mercier, I.1
  • 129
    • 84938317531 scopus 로고    scopus 로고
    • Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein
    • Janakiram, M. et al. Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein. Clin. Cancer Res. 21, 2359-2366 (2015).
    • (2015) Clin. Cancer Res , vol.21 , pp. 2359-2366
    • Janakiram, M.1
  • 130
    • 84879668353 scopus 로고    scopus 로고
    • B7 H5 costimulates human T cells via CD28H
    • Zhu, Y. et al. B7 H5 costimulates human T cells via CD28H. Nat. Commun. 4, 2043 (2013).
    • (2013) Nat. Commun , vol.4 , Issue.2043
    • Zhu, Y.1
  • 131
    • 33744914590 scopus 로고    scopus 로고
    • A butyrophilin-like molecule that functions to inhibit T cell activation
    • Nguyen, T., Liu, X. K., Zhang, Y. & Dong, C. BTNL2, a butyrophilin-like molecule that functions to inhibit T cell activation. J. Immunol. 176, 7354-7360 (2006).
    • (2006) J. Immunol , vol.176 , pp. 7354-7360
    • Nguyen, T.1    Liu, X.K.2    Zhang, Y.3    Btnl, D.C.4
  • 132
    • 20144388906 scopus 로고    scopus 로고
    • Sarcoidosis is associated with a truncating splice site mutation in BTNL2
    • Valentonyte, R. et al. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat. Genet. 37, 357-364 (2005).
    • (2005) Nat. Genet , vol.37 , pp. 357-364
    • Valentonyte, R.1
  • 133
    • 84904971095 scopus 로고    scopus 로고
    • Immune modulation by butyrophilins
    • Arnett, H. A. & Viney, J. L. Immune modulation by butyrophilins. Nat. Rev. Immunol. 14, 559-569 (2014).
    • (2014) Nat. Rev. Immunol , vol.14 , pp. 559-569
    • Arnett, H.A.1    Viney, J.L.2
  • 134
    • 84884150338 scopus 로고    scopus 로고
    • Germline missense variants in the BTNL2 gene are associated with prostate cancer susceptibility
    • Fitzgerald, L. M. et al. Germline missense variants in the BTNL2 gene are associated with prostate cancer susceptibility. Cancer Epidemiol. Biomarkers Prev. 22, 1520-1528 (2013).
    • (2013) Cancer Epidemiol. Biomarkers Prev , vol.22 , pp. 1520-1528
    • Fitzgerald, L.M.1
  • 135
    • 84938371758 scopus 로고    scopus 로고
    • A genome-wide association study suggests evidence of variants at 6p21.32 associated with marginal zone lymphoma
    • Vijai, J. et al. A genome-wide association study suggests evidence of variants at 6p21.32 associated with marginal zone lymphoma. Cancer Res. 74 (Suppl. 19), 5071 (2014).
    • (2014) Cancer Res , vol.74 , pp. 5071
    • Vijai, J.1
  • 138
    • 84898969025 scopus 로고    scopus 로고
    • DNAM 1 control of natural killer cells functions through nectin and nectin-like proteins
    • de Andrade, L. F., Smyth, M. J. & Martinet, L. DNAM 1 control of natural killer cells functions through nectin and nectin-like proteins. Immunol. Cell Biol. 92, 237-244 (2014).
    • (2014) Immunol. Cell Biol , vol.92 , pp. 237-244
    • De Andrade, L.F.1    Smyth, M.J.2    Martinet, L.3
  • 139
    • 85014399840 scopus 로고    scopus 로고
    • Mechanisms of TIGIT-driven immune suppression in cancer
    • Sema Kurtulus, S. et al. Mechanisms of TIGIT-driven immune suppression in cancer. J. Immunother. Cancer 2 (Suppl. 3), O13 (2014).
    • (2014) J. Immunother. Cancer , vol.2 , pp. O13
    • Sema Kurtulus, S.1
  • 140
    • 84929000784 scopus 로고    scopus 로고
    • TIGIT and PD 1 impair tumor antigen-specific CD8+ T cells in melanoma patients
    • Chauvin, J. M. et al. TIGIT and PD 1 impair tumor antigen-specific CD8+ T cells in melanoma patients. J. Clin. Invest. 125, 2046-2058 (2015).
    • (2015) J. Clin. Invest , vol.125 , pp. 2046-2058
    • Chauvin, J.M.1
  • 141
    • 84919494669 scopus 로고    scopus 로고
    • The immunoreceptor TIGIT regulates antitumor and antiviral CD8+ T cell effector function
    • Johnston, R. J. et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8+ T cell effector function. Cancer Cell 26, 923-937 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 923-937
    • Johnston, R.J.1
  • 142
    • 84929001442 scopus 로고    scopus 로고
    • Immunosurveillance and therapy of multiple myeloma are CD226 dependent
    • Guillerey, C. et al. Immunosurveillance and therapy of multiple myeloma are CD226 dependent. J. Clin. Invest. 125, 2077-2089 (2015).
    • (2015) J. Clin. Invest , vol.125 , pp. 2077-2089
    • Guillerey, C.1
  • 143
    • 84930092220 scopus 로고    scopus 로고
    • Analysis of loss of function variants and 20 risk factor phenotypes in 8, 554 individuals identifies loci influencing chronic disease
    • Li, A. H. et al. Analysis of loss of function variants and 20 risk factor phenotypes in 8, 554 individuals identifies loci influencing chronic disease. Nat. Genet. 47, 640-642 (2015).
    • (2015) Nat. Genet , vol.47 , pp. 640-642
    • Li, A.H.1
  • 144
    • 44949125431 scopus 로고    scopus 로고
    • Correlation between NK function and response to trastuzumab in metastatic breast cancer patients
    • Beano, A. et al. Correlation between NK function and response to trastuzumab in metastatic breast cancer patients. J. Transl. Med. 6, 25 (2008).
    • (2008) J. Transl. Med , vol.6 , pp. 25
    • Beano, A.1
  • 145
    • 84869856060 scopus 로고    scopus 로고
    • A Phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission
    • Vey, N. et al. A Phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission. Blood 120, 4317-4323 (2012).
    • (2012) Blood , vol.120 , pp. 4317-4323
    • Vey, N.1
  • 146
    • 0142197631 scopus 로고    scopus 로고
    • Roles of the NKG2D immunoreceptor and its ligands
    • Raulet, D. H. Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 3, 781-790 (2003).
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 781-790
    • Raulet, D.H.1
  • 148
    • 84864914363 scopus 로고    scopus 로고
    • Hematological malignancies escape from NK cell innate immune surveillance: Mechanisms and therapeutic implications
    • Farnault, L., Sanchez, C., Baier, C., Le Treut, T. & Costello, R. T. Hematological malignancies escape from NK cell innate immune surveillance: mechanisms and therapeutic implications. Clin. Dev. Immunol. 2012, 421702 (2012).
    • (2012) Clin. Dev. Immunol
    • Farnault, L.1    Sanchez, C.2    Baier, C.3    Le Treut, T.4    Costello, R.T.5
  • 149
    • 84929049924 scopus 로고    scopus 로고
    • Targeting MICA with therapeutic antibodies for the treatment of cancer (Poster)
    • Bonnafous, C. et al. Targeting MICA with therapeutic antibodies for the treatment of cancer (Poster). J. Immunother. Cancer 1 (Suppl. 1), P41 (2013).
    • (2013) J. Immunother. Cancer , vol.1 , Issue.SUPPL1 , pp. P41
    • Bonnafous, C.1
  • 150
    • 1642473189 scopus 로고    scopus 로고
    • The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA e through mostly shared but partly distinct sets of HLA e residues
    • Wada, H., Matsumoto, N., Maenaka, K., Suzuki, K. & Yamamoto, K. The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA E through mostly shared but partly distinct sets of HLA E residues. Eur. J. Immunol. 34, 81-90 (2004).
    • (2004) Eur. J. Immunol , vol.34 , pp. 81-90
    • Wada, H.1    Matsumoto, N.2    Maenaka, K.3    Suzuki, K.4    Yamamoto, K.5
  • 151
    • 84897944609 scopus 로고    scopus 로고
    • Cancer-induced alterations of NK mediated target recognition: Current and investigational pharmacological strategies aiming at restoring NK mediated anti-tumor activity
    • Chretien, A. S. et al. Cancer-induced alterations of NK mediated target recognition: current and investigational pharmacological strategies aiming at restoring NK mediated anti-tumor activity. Front. Immunol. 5, 122 (2014).
    • (2014) Front. Immunol , vol.5 , Issue.122
    • Chretien, A.S.1
  • 152
    • 77952102491 scopus 로고    scopus 로고
    • HLA G and immune evasion in cancer cells
    • Sheu, J. & Shih, le-M. HLA G and immune evasion in cancer cells. J. Formos Med. Assoc. 109, 248-257 (2010).
    • (2010) J. Formos Med. Assoc , vol.109 , pp. 248-257
    • Sheu, J.1    Shihle-M2
  • 153
    • 84900331990 scopus 로고    scopus 로고
    • Some basic aspects of HLA G biology
    • Alegre, E. et al. Some basic aspects of HLA G biology. J. Immunol. Res. 2014, 657625 (2014).
    • (2014) J. Immunol. Res , pp. 657625
    • Alegre, E.1
  • 154
    • 84861707985 scopus 로고    scopus 로고
    • The immunosuppressive molecule HLA-G and its clinical implications
    • González, A. et al. The immunosuppressive molecule HLA-G and its clinical implications. Crit. Rev. Clin. Lab Sci. 49, 63-84 (2012).
    • (2012) Crit. Rev. Clin. Lab Sci , vol.49 , pp. 63-84
    • González, A.1
  • 155
    • 31544451600 scopus 로고    scopus 로고
    • 2B4 (CD244), NTB A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells
    • Stark, S. & Watzl, C. 2B4 (CD244), NTB A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells. Int. Immunol. 18, 241-247 (2006).
    • (2006) Int. Immunol , vol.18 , pp. 241-247
    • Stark, S.1    Watzl, C.2
  • 156
    • 0027220087 scopus 로고
    • Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes
    • Valiante, N. M. & Trinchieri, G. Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes. J. Exp. Med. 178, 1397-1406 (1993).
    • (1993) J. Exp. Med , vol.178 , pp. 1397-1406
    • Valiante, N.M.1    Trinchieri, G.2
  • 157
    • 34247595404 scopus 로고    scopus 로고
    • Prospects for the use of NK cells in immunotherapy of human cancer
    • Ljunggren, H. G. & Malmberg, K. J. Prospects for the use of NK cells in immunotherapy of human cancer. Nat. Rev. Immunol. 7, 329-339 (2007).
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 329-339
    • Ljunggren, H.G.1    Malmberg, K.J.2
  • 158
    • 84860852600 scopus 로고    scopus 로고
    • Blocking IDO activity to enhance anti-tumor immunity
    • Munn, D. H. Blocking IDO activity to enhance anti-tumor immunity. Front. Biosci. (Elite Ed) 4, 734-745 (2012).
    • (2012) Front. Biosci. (Elite Ed) , vol.4 , pp. 734-745
    • Munn, D.H.1
  • 159
    • 84920081022 scopus 로고    scopus 로고
    • Preliminary results from a phase 1/2 study of INCB024360 combined with ipilimumab (ipi) in patients (pts) with melanoma
    • Suppl
    • Gibney, G. T. et al. Preliminary results from a phase 1/2 study of INCB024360 combined with ipilimumab (ipi) in patients (pts) with melanoma. J. Clin. Oncol. 32 Suppl., 3010 (2014).
    • (2014) J. Clin. Oncol , vol.32 , Issue.3010
    • Gibney, G.T.1
  • 160
    • 84908005764 scopus 로고    scopus 로고
    • A first in man phase i trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors
    • Soliman, H. H. et al. A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors. Oncotarget 5, 8136-8146 (2014).
    • (2014) Oncotarget , vol.5 , pp. 8136-8146
    • Soliman, H.H.1
  • 163
    • 75949103899 scopus 로고    scopus 로고
    • Integrin-TGF-β crosstalk in fibrosis, cancer and wound healing
    • Margadant, C. & Sonnenberg, A. Integrin-TGF-β crosstalk in fibrosis, cancer and wound healing. EMBO Rep. 11, 97-105 (2010).
    • (2010) EMBO Rep , vol.11 , pp. 97-105
    • Margadant, C.1    Sonnenberg, A.2
  • 164
    • 84899071195 scopus 로고    scopus 로고
    • Defining a therapeutic window for the novel TGF-β inhibitor LY2157299 monohydrate based on a pharmacokinetic/pharmacodynamic model
    • Gueorguieva, I. et al. Defining a therapeutic window for the novel TGF-β inhibitor LY2157299 monohydrate based on a pharmacokinetic/pharmacodynamic model. Br. J. Clin. Pharmacol. 77, 796-807 (2014).
    • (2014) Br. J. Clin. Pharmacol , vol.77 , pp. 796-807
    • Gueorguieva, I.1
  • 165
    • 84874607100 scopus 로고    scopus 로고
    • TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer
    • Bhola, N. E. et al. TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer. J. Clin. Invest. 123, 1348-1358 (2013).
    • (2013) J. Clin. Invest , vol.123 , pp. 1348-1358
    • Bhola, N.E.1
  • 166
    • 84869211657 scopus 로고    scopus 로고
    • Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy
    • Bedi, A. et al. Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy. Mol. Cancer Ther. 11, 2429-2439 (2012).
    • (2012) Mol. Cancer Ther , vol.11 , pp. 2429-2439
    • Bedi, A.1
  • 167
    • 84918767156 scopus 로고    scopus 로고
    • Combinatorial TGF β signaling blockade and anti-CTLA 4 antibody immunotherapy in a murine BRAFV600E PTEN-/- transgenic model of melanoma
    • Suppl
    • Hanks, B. A., Holtzhausen, A., Evans, K., Heid, M. & Blobe, G. C. Combinatorial TGF β signaling blockade and anti-CTLA 4 antibody immunotherapy in a murine BRAFV600E PTEN-/- transgenic model of melanoma. J. Clin. Oncol. 32 Suppl., 3011 (2014).
    • (2014) J. Clin. Oncol , vol.32 , Issue.3011
    • Hanks, B.A.1    Holtzhausen, A.2    Evans, K.3    Heid, M.4    Blobe, G.C.5
  • 168
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson, W. R. & Hay, M. P. Targeting hypoxia in cancer therapy. Nat. Rev. Cancer 11, 393-410 (2011).
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 169
    • 33748357735 scopus 로고    scopus 로고
    • A2A adenosine receptor protects tumors from antitumor T cells
    • Ohta, A. et al. A2A adenosine receptor protects tumors from antitumor T cells. Proc. Natl Acad. Sci. USA 103, 13132-13137 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 13132-13137
    • Ohta, A.1
  • 170
    • 84918545478 scopus 로고    scopus 로고
    • Adenosine A2A receptors intrinsically regulate CD8+ T cells in the tumor microenvironment
    • Cekic, C. & Linden, J. Adenosine A2A receptors intrinsically regulate CD8+ T cells in the tumor microenvironment. Cancer Res. 74, 7239-7249 (2014).
    • (2014) Cancer Res , vol.74 , pp. 7239-7249
    • Cekic, C.1    Linden, J.2
  • 171
    • 84927511762 scopus 로고    scopus 로고
    • Towards next generation adenosine A2A receptor antagonists
    • Jones, G. B. & Yuan, G. Towards next generation adenosine A2A receptor antagonists. Curr. Med. Chem. 21, 3918-3935 (2014).
    • (2014) Curr. Med. Chem , vol.21 , pp. 3918-3935
    • Jones, G.B.1    Yuan, G.2
  • 172
    • 41949083203 scopus 로고    scopus 로고
    • Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade
    • Yegutkin, G. G. Nucleotide- and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade. Biochim. Biophys. Acta 1783, 673-694 (2008).
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 673-694
    • Yegutkin, G.G.1
  • 173
    • 77951234655 scopus 로고    scopus 로고
    • Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells
    • Mandapathil, M. et al. Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells. J. Biol. Chem. 285, 7176-7186 (2010).
    • (2010) J. Biol. Chem , vol.285 , pp. 7176-7186
    • Mandapathil, M.1
  • 174
    • 84913604670 scopus 로고    scopus 로고
    • Adenosine limits the therapeutic effectiveness of anti CTLA4 mAb in a mouse melanoma model
    • Iannone, R., Miele, L., Maiolino, P., Pinto, A. & Morello, S. Adenosine limits the therapeutic effectiveness of anti CTLA4 mAb in a mouse melanoma model. Am. J. Cancer Res. 4, 172-181 (2014).
    • (2014) Am. J. Cancer Res , vol.4 , pp. 172-181
    • Iannone, R.1    Miele, L.2    Maiolino, P.3    Pinto, A.4    Morello, S.5
  • 175
    • 84886432843 scopus 로고    scopus 로고
    • Targeting CD73 enhances the antitumor activity of anti PD 1 and anti-CTLA 4 mAbs
    • Allard, B., Pommey, S., Smyth, M. J. & Stagg, J. Targeting CD73 enhances the antitumor activity of anti PD 1 and anti-CTLA 4 mAbs. Clin. Cancer Res. 19, 5626-5635 (2013).
    • (2013) Clin. Cancer Res , vol.19 , pp. 5626-5635
    • Allard, B.1    Pommey, S.2    Smyth, M.J.3    Stagg, J.4
  • 176
    • 84929008590 scopus 로고    scopus 로고
    • Immunological mechanisms of the antitumor effects of supplemental oxygenation
    • Hatfield, S. M. et al. Immunological mechanisms of the antitumor effects of supplemental oxygenation. Sci. Transl. Med. 7, 277ra30 (2015).
    • (2015) Sci. Transl. Med , vol.7 , pp. 277ra30
    • Hatfield, S.M.1
  • 177
    • 84918577973 scopus 로고    scopus 로고
    • Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment
    • Cekic, C., Day, Y. J., Sag, D. & Linden, J. Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment. Cancer Res. 74, 7250-7259 (2014).
    • (2014) Cancer Res , vol.74 , pp. 7250-7259
    • Cekic, C.1    Day, Y.J.2    Sag, D.3    Linden, J.4
  • 178
    • 84899084303 scopus 로고    scopus 로고
    • Targeting the adenosine A2b receptor in the tumor microenvironment overcomes local immunosuppression by myeloid-derived suppressor cells
    • Morello, S. & Miele, L. Targeting the adenosine A2b receptor in the tumor microenvironment overcomes local immunosuppression by myeloid-derived suppressor cells. OncoImmunology 3, e27989 (2014).
    • (2014) OncoImmunology , vol.3 , pp. e27989
    • Morello, S.1    Miele, L.2
  • 179
    • 40249106427 scopus 로고    scopus 로고
    • Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review
    • Hoskin, D. W., Mader, J. S., Furlong, S. J., Conrad, D. M. & Blay, J. Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review). Int. J. Oncol. 32, 527-535 (2008).
    • (2008) Int. J. Oncol , vol.32 , pp. 527-535
    • Hoskin, D.W.1    Mader, J.S.2    Furlong, S.J.3    Conrad, D.M.4    Blay, J.5
  • 180
    • 84863991235 scopus 로고    scopus 로고
    • Myeloid suppressor cell depletion augments antitumor activity in lung cancer
    • Srivastava, M. K. et al. Myeloid suppressor cell depletion augments antitumor activity in lung cancer. PLoS ONE 7, e40677 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e40677
    • Srivastava, M.K.1
  • 181
    • 84890281217 scopus 로고    scopus 로고
    • Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti PD L1 immunotherapy in pancreatic cancer
    • Feig, C. et al. Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti PD L1 immunotherapy in pancreatic cancer. Proc. Natl Acad. Sci. USA 110, 20212-20217 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 20212-20217
    • Feig, C.1
  • 182
    • 33749576772 scopus 로고    scopus 로고
    • Plasma protein β 2 glycoprotein 1 mediates interaction between the anti-tumor monoclonal antibody 3G4 and anionic phospholipids on endothelial cells
    • Luster, T. A. et al. Plasma protein β 2 glycoprotein 1 mediates interaction between the anti-tumor monoclonal antibody 3G4 and anionic phospholipids on endothelial cells. J. Biol. Chem. 281, 29863-29871 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 29863-29871
    • Luster, T.A.1
  • 183
    • 84938338794 scopus 로고    scopus 로고
    • Randomized, blinded, placebo-controlled phase II trial of docetaxel and bavituximab as second-line therapy in locally advanced or metastatic non-squamous non-small cell lung cancer
    • Suppl
    • Shtivelband, M. et al. Randomized, blinded, placebo-controlled phase II trial of docetaxel and bavituximab as second-line therapy in locally advanced or metastatic non-squamous non-small cell lung cancer. J. Clin. Oncol. 31 Suppl., 8095 (2013).
    • (2013) J. Clin. Oncol , vol.31 , Issue.8095
    • Shtivelband, M.1
  • 184
    • 84938361723 scopus 로고    scopus 로고
    • Antibody-mediated blockade of phosphatidylserine enhances the antitumor activity of targeted therapy and immune checkpoint inhibitors by affecting myeloid and lymphocyte populations in the tumor microenvironment
    • Cancer
    • Yopp, A. et al. Antibody-mediated blockade of phosphatidylserine enhances the antitumor activity of targeted therapy and immune checkpoint inhibitors by affecting myeloid and lymphocyte populations in the tumor microenvironment. J. Immunother. Cancer 2 (Suppl. 3), P266 (2014).
    • (2014) J. Immunother. , vol.2 , pp. P266
    • Yopp, A.1
  • 185
    • 84938395024 scopus 로고    scopus 로고
    • Antibody-mediated phosphatidylserine blockade significantly enhances the efficacy of downstream immune checkpoint inhibition in K1735 mouse melanoma
    • Huang, X. et al. Antibody-mediated phosphatidylserine blockade significantly enhances the efficacy of downstream immune checkpoint inhibition in K1735 mouse melanoma. J. Immunother. Cancer 2 (Suppl. 3), P205 (2014).
    • (2014) J. Immunother. Cancer , vol.2 , pp. P205
    • Huang, X.1
  • 186
    • 84906903314 scopus 로고    scopus 로고
    • Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): A multicentre, double-blind, randomised phase 3 trial
    • Garon, E. B. et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial. Lancet 384, 665-673 (2014).
    • (2014) Lancet , vol.384 , pp. 665-673
    • Garon, E.B.1
  • 187
    • 84879733796 scopus 로고    scopus 로고
    • Anti CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T cell response
    • Tseng, D. et al. Anti CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T cell response. Proc. Natl Acad. Sci. USA 110, 11103-11108 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 11103-11108
    • Tseng, D.1
  • 188
    • 84879797224 scopus 로고    scopus 로고
    • Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies
    • Weiskopf, K. et al. Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science 341, 88-91 (2013).
    • (2013) Science , vol.341 , pp. 88-91
    • Weiskopf, K.1
  • 189
    • 67650646082 scopus 로고    scopus 로고
    • CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
    • Jaiswal, S. et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 138, 271-285 (2009).
    • (2009) Cell , vol.138 , pp. 271-285
    • Jaiswal, S.1
  • 190
    • 77956150056 scopus 로고    scopus 로고
    • Anti CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma
    • Chao, M. P. et al. Anti CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell 142, 699-713 (2010).
    • (2010) Cell , vol.142 , pp. 699-713
    • Chao, M.P.1
  • 191
    • 85047692172 scopus 로고    scopus 로고
    • Therapeutic vaccines for cancer: An overview of clinical trials
    • Melero, I. et al. Therapeutic vaccines for cancer: an overview of clinical trials. Nat. Rev. Clin. Oncol. 11, 509-524 (2014).
    • (2014) Nat. Rev. Clin. Oncol , vol.11 , pp. 509-524
    • Melero, I.1
  • 192
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7 h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • Taube, J. M. et al. Colocalization of inflammatory response with B7 h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci. Transl. Med. 4, 127ra37 (2012).
    • (2012) Sci. Transl. Med , vol.4 , pp. 127ra37
    • Taube, J.M.1
  • 193
    • 0022515473 scopus 로고
    • Lymphocytic infiltration and survival in rectal cancer
    • Jass, J. R. Lymphocytic infiltration and survival in rectal cancer. J. Clin. Pathol. 39, 585-589 (1986).
    • (1986) J. Clin. Pathol , vol.39 , pp. 585-589
    • Jass, J.R.1
  • 196
    • 84866852663 scopus 로고    scopus 로고
    • Cancer classification using the Immunoscore: A worldwide task force
    • Galon, J. et al. Cancer classification using the Immunoscore: a worldwide task force. J. Transl. Med. 10, 205 (2012).
    • (2012) J. Transl. Med , vol.10 , Issue.205
    • Galon, J.1
  • 197
    • 84877076923 scopus 로고    scopus 로고
    • From the immune contexture to the Immunoscore: The role of prognostic and predictive immune markers in cancer
    • Angell, H. & Galon, J. From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer. Curr. Opin. Immunol. 25, 261-267 (2013).
    • (2013) Curr. Opin. Immunol , vol.25 , pp. 261-267
    • Angell, H.1    Galon, J.2
  • 198
    • 84868277668 scopus 로고    scopus 로고
    • 12 chemokine gene signature identifies lymph node-like structures in melanoma: Potential for patient selection for immunotherapy?
    • Messina, J. L. et al. 12 chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy?. Sci. Rep. 2, 765 (2012).
    • (2012) Sci Rep , vol.2 , Issue.765
    • Messina, J.L.1
  • 199
    • 10344220548 scopus 로고    scopus 로고
    • Costimulatory B7 H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target
    • Thompson, R. H. et al. Costimulatory B7 H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target. Proc. Natl Acad. Sci. USA 101, 17174-17179 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 17174-17179
    • Thompson, R.H.1
  • 200
    • 84938350053 scopus 로고    scopus 로고
    • Orchestration and prognostic significance of immune checkpoints in the microenvironment of primary and metastatic renal cell cancer
    • Giraldo, N. A. et al. Orchestration and prognostic significance of immune checkpoints in the microenvironment of primary and metastatic renal cell cancer. Clin. Cancer Res. http://dx.doi. org/10.1158/1078-0432.CCR-14-2926 (2015).
    • (2015) Clin. Cancer Res
    • Giraldo, N.A.1
  • 201
    • 84920956732 scopus 로고    scopus 로고
    • PD 1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh, P. C. et al. PD 1 blockade induces responses by inhibiting adaptive immune resistance. Nature 515, 568-571 (2014).
    • (2014) Nature , vol.515 , pp. 568-571
    • Tumeh, P.C.1
  • 202
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter, D. L., Levine, B. L., Kalos, M., Bagg, A. & June, C. H. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N. Engl. J.Med. 365, 725-733 (2011).
    • (2011) N. Engl. J.Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 203
    • 84886397930 scopus 로고    scopus 로고
    • Anti PD 1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells
    • John, L. B. et al. Anti PD 1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells. Clin. Cancer Res. 19, 5636-5646 (2013).
    • (2013) Clin. Cancer Res , vol.19 , pp. 5636-5646
    • John, L.B.1
  • 204
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • Wolchok, J. D. et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin. Cancer Res. 15, 7412-7420 (2009).
    • (2009) Clin. Cancer Res , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1
  • 205
    • 0021079551 scopus 로고
    • Vitiligo in patients with metastatic melanoma: A good prognostic sign
    • Nordlund, J. J. et al. Vitiligo in patients with metastatic melanoma: a good prognostic sign. J. Am. Acad. Dermatol. 9, 689-696 (1983).
    • (1983) J. Am. Acad. Dermatol , vol.9 , pp. 689-696
    • Nordlund, J.J.1
  • 206
    • 0023262933 scopus 로고
    • Prognostic significance of hypopigmentation in malignant melanoma
    • Bystryn, J. C., Rigel, D., Friedman, R. J. & Kopf, A. Prognostic significance of hypopigmentation in malignant melanoma. Arch. Dermatol. 123, 1053-1055 (1987).
    • (1987) Arch. Dermatol , vol.123 , pp. 1053-1055
    • Bystryn, J.C.1    Rigel, D.2    Friedman, R.J.3    Kopf, A.4
  • 207
    • 0025641296 scopus 로고
    • Primary hypothyroidism associated with interleukin 2 and interferon α 2 therapy of melanoma and renal carcinoma
    • Scalzo, S. et al. Primary hypothyroidism associated with interleukin 2 and interferon α 2 therapy of melanoma and renal carcinoma. Eur. J. Cancer 26, 1152-1156 (1990).
    • (1990) Eur. J. Cancer , vol.26 , pp. 1152-1156
    • Scalzo, S.1
  • 208
    • 0028205754 scopus 로고
    • Antiphospholipid syndrome associated with immunotherapy for patients with melanoma
    • Becker, J. C., Winkler, B., Klingert, S. & Brocker, E. B. Antiphospholipid syndrome associated with immunotherapy for patients with melanoma. Cancer 73, 1621-1624 (1994).
    • (1994) Cancer , vol.73 , pp. 1621-1624
    • Becker, J.C.1    Winkler, B.2    Klingert, S.3    Brocker, E.B.4
  • 209
    • 0030008301 scopus 로고    scopus 로고
    • Vitiligo in patients with melanoma: Normal tissue antigens can be targets for cancer immunotherapy
    • Rosenberg, S. A. & White, D. E. Vitiligo in patients with melanoma: normal tissue antigens can be targets for cancer immunotherapy. J. Immunother. Emphasis Tumor Immunol. 19, 81-84 (1996).
    • (1996) J. Immunother. Emphasis Tumor Immunol , vol.19 , pp. 81-84
    • Rosenberg, S.A.1    White, D.E.2
  • 210
    • 0023888654 scopus 로고
    • Hypothyroidism after treatment with interleukin 2 and lymphokine-activated killer cells
    • Atkins, M. B. et al. Hypothyroidism after treatment with interleukin 2 and lymphokine-activated killer cells. N. Engl. J. Med. 318, 1557-1563 (1988).
    • (1988) N. Engl. J. Med , vol.318 , pp. 1557-1563
    • Atkins, M.B.1
  • 211
    • 24944459890 scopus 로고    scopus 로고
    • Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T lymphocyte antigen 4
    • Attia, P. et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T lymphocyte antigen 4. J. Clin. Oncol. 23, 6043-6053 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 6043-6053
    • Attia, P.1
  • 212
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman, P. B. et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N. Engl. J. Med. 364, 2507-2516 (2011).
    • (2011) N. Engl. J. Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1
  • 213
    • 33744792341 scopus 로고    scopus 로고
    • Enterocolitis in patients with cancer after antibody blockade of cytotoxic T lymphocyte-associated antigen 4
    • Beck, K. E. et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T lymphocyte-associated antigen 4. J. Clin. Oncol. 24, 2283-2289 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 2283-2289
    • Beck, K.E.1
  • 215
    • 0034194329 scopus 로고    scopus 로고
    • Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA 4 blockade
    • Hurwitz, A. A. et al. Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA 4 blockade. Cancer Res. 60, 2444-2448 (2000).
    • (2000) Cancer Res , vol.60 , pp. 2444-2448
    • Hurwitz, A.A.1
  • 216
    • 84908664534 scopus 로고    scopus 로고
    • Ipilimumab plus sargramostim versus ipilimumab alone for treatment of metastatic melanoma: A randomized clinical trial
    • Hodi, F. S. et al. Ipilimumab plus sargramostim versus ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial. JAMA 312, 1744-1753 (2014).
    • (2014) JAMA , vol.312 , pp. 1744-1753
    • Hodi, F.S.1
  • 217
    • 34447121852 scopus 로고    scopus 로고
    • MFG E8 mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM CSF
    • Jinushi, M. et al. MFG E8 mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM CSF. J. Clin. Invest. 117, 1902-1913 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 1902-1913
    • Jinushi, M.1
  • 218
    • 79551717184 scopus 로고    scopus 로고
    • Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma
    • Rini, B. I. et al. Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma. Cancer 117, 758- 767 (2011).
    • (2011) Cancer , vol.117 , pp. 758-767
    • Rini, B.I.1
  • 219
    • 27844458057 scopus 로고    scopus 로고
    • Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: A phase I/II study
    • Maker, A. V. et al. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann. Surg. Oncol. 12, 1005-1016 (2005).
    • (2005) Ann. Surg. Oncol , vol.12 , pp. 1005-1016
    • Maker, A.V.1
  • 220
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert, C. et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364, 2517-2526 (2011).
    • (2011) N. Engl. J. Med , vol.364 , pp. 2517-2526
    • Robert, C.1
  • 221
    • 84977126665 scopus 로고    scopus 로고
    • The role of Fc gamma receptors in the activity of immunomodulatory antibodies for cancer
    • Stewart, R. et al. The role of Fc gamma receptors in the activity of immunomodulatory antibodies for cancer. J. Immunother. Cancer 2, 29 (2014).
    • (2014) J. Immunother. Cancer , vol.2 , Issue.29
    • Stewart, R.1
  • 222
    • 84938333423 scopus 로고    scopus 로고
    • Phase i study of RG7155, a novel anti-CSF1R antibody, in patients with advanced/metastatic solid tumors
    • Suppl.; abstr
    • Gomez-Roca, C. A. et al. Phase I study of RG7155, a novel anti-CSF1R antibody, in patients with advanced/metastatic solid tumors. J. Clin. Oncol. 33 (Suppl.; abstr.), 3005 (2015).
    • (2015) J. Clin. Oncol , vol.33 , Issue.3005
    • Gomez-Roca, C.A.1
  • 223
    • 84884271914 scopus 로고    scopus 로고
    • Fc dependent depletion of tumor-infiltrating regulatory T cells co defines the efficacy of anti-CTLA 4 therapy against melanoma
    • Simpson, T. R. et al. Fc dependent depletion of tumor-infiltrating regulatory T cells co defines the efficacy of anti-CTLA 4 therapy against melanoma. J. Exp. Med. 210, 1695-1710 (2013).
    • (2013) J. Exp. Med , vol.210 , pp. 1695-1710
    • Simpson, T.R.1
  • 224
    • 84878936788 scopus 로고    scopus 로고
    • Anti-CTLA 4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
    • Selby, M. J. et al. Anti-CTLA 4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Cancer Immunol. Res. 1, 32-42 (2013).
    • (2013) Cancer Immunol. Res , vol.1 , pp. 32-42
    • Selby, M.J.1
  • 225
    • 84925373898 scopus 로고    scopus 로고
    • Prognostic and predictive markers for the new immunotherapies
    • Mahoney, K. M. & Atkins, M. B. Prognostic and predictive markers for the new immunotherapies. Oncology (Williston Park) 28 (Suppl. 3), 39-48 (2014).
    • (2014) Oncology (Williston Park) , vol.28 , pp. 39-48
    • Mahoney, K.M.1    Atkins, M.B.2
  • 226
    • 78049370405 scopus 로고    scopus 로고
    • Integrative analysis reveals selective 9p24.1 amplification, increased PD 1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B cell lymphoma
    • Green, M. R. et al. Integrative analysis reveals selective 9p24.1 amplification, increased PD 1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B cell lymphoma. Blood 116, 3268-3277 (2010).
    • (2010) Blood , vol.116 , pp. 3268-3277
    • Green, M.R.1
  • 227
    • 84925221855 scopus 로고    scopus 로고
    • PD 1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
    • Ansell, S. M. et al. PD 1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N. Engl. J. Med. 372, 311-319 (2015).
    • (2015) N. Engl. J. Med , vol.372 , pp. 311-319
    • Ansell, S.M.1
  • 228
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD 1 PD 1 ligands, and other features of the tumor immune microenvironment with response to anti PD 1 therapy
    • Taube, J. M. et al. Association of PD 1, PD 1 ligands, and other features of the tumor immune microenvironment with response to anti PD 1 therapy. Clin. Cancer Res. 20, 5064-5074 (2014).
    • (2014) Clin. Cancer Res , vol.20 , pp. 5064-5074
    • Taube, J.M.1
  • 229
    • 84931424042 scopus 로고    scopus 로고
    • Phase III, randomized trial (CheckMate 057) of nivolumab (NIVO) versus docetaxel (DOC) in advanced non-squamous cell (non SQ) non-small cell lung cancer (NSCLC
    • Suppl
    • Paz-Ares, L. et al. Phase III, randomized trial (CheckMate 057) of nivolumab (NIVO) versus docetaxel (DOC) in advanced non-squamous cell (non SQ) non-small cell lung cancer (NSCLC). J. Clin. Oncol. 33 Suppl., LBA109 (2015).
    • (2015) J. Clin. Oncol , vol.33 , pp. LBA109
    • Paz-Ares, L.1
  • 230
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • Brahmer, J. et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N. Engl. J. Med. http://dx.doi.org/10.1056/NEJMoa1504627 (2015).
    • (2015) N. Engl. J. Med
    • Brahmer, J.1
  • 231
    • 84947704341 scopus 로고    scopus 로고
    • CEA-targeted engineered IL2: Clinical confirmation of tumor targeting and evidence of intra-tumoral immune activation
    • Suppl.
    • Schellens, J. et al. CEA-targeted engineered IL2: clinical confirmation of tumor targeting and evidence of intra-tumoral immune activation. J. Clin. Oncol. 33 Suppl., 3016 (2015).
    • (2015) J. Clin. Oncol , vol.33 , Issue.3016
    • Schellens, J.1
  • 232
    • 84886421073 scopus 로고    scopus 로고
    • Antagonist antibodies to PD 1 and B7 H1 (PD L1) in the treatment of advanced human cancer-response
    • Sznol, M. & Chen, L. Antagonist antibodies to PD 1 and B7 H1 (PD L1) in the treatment of advanced human cancer-response. Clin. Cancer Res. 19, 5542 (2013).
    • (2013) Clin. Cancer Res , vol.19 , Issue.5542
    • Sznol, M.1    Chen, L.2
  • 233
    • 84907501256 scopus 로고    scopus 로고
    • Programmed death-ligand 1 (PD L1) expression in various tumor types
    • Grosso, J. et al. Programmed death-ligand 1 (PD L1) expression in various tumor types. J. Immunother. Cancer 1 (Suppl 1), P53 (2013).
    • (2013) J. Immunother. Cancer , vol.1 , Issue.SUPPL1 , pp. P53
    • Grosso, J.1
  • 234
    • 0037307930 scopus 로고    scopus 로고
    • Blockade of programmed death 1 ligands on dendritic cells enhances T cell activation and cytokine production
    • Brown, J. A. et al. Blockade of programmed death 1 ligands on dendritic cells enhances T cell activation and cytokine production. J. Immunol. 170, 1257-1266 (2003).
    • (2003) J. Immunol , vol.170 , pp. 1257-1266
    • Brown, J.A.1
  • 235
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7 H1 promotes T cell apoptosis: A potential mechanism of immune evasion
    • Dong, H. et al. Tumor-associated B7 H1 promotes T cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8, 793-800 (2002).
    • (2002) Nat. Med , vol.8 , pp. 793-800
    • Dong, H.1
  • 236
    • 20244384862 scopus 로고    scopus 로고
    • Clinical significance of programmed death 1 ligand 1 and programmed death 1 ligand 2 expression in human esophageal cancer
    • Ohigashi, Y. et al. Clinical significance of programmed death 1 ligand 1 and programmed death 1 ligand 2 expression in human esophageal cancer. Clin. Cancer Res. 11, 2947-2953 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 2947-2953
    • Ohigashi, Y.1
  • 237
    • 34247532726 scopus 로고    scopus 로고
    • Clinical significance and therapeutic potential of the programmed death 1 ligand/programmed death 1 pathway in human pancreatic cancer
    • Nomi, T. et al. Clinical significance and therapeutic potential of the programmed death 1 ligand/programmed death 1 pathway in human pancreatic cancer. Clin. Cancer Res. 13, 2151-2157 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 2151-2157
    • Nomi, T.1
  • 238
    • 33847611968 scopus 로고    scopus 로고
    • Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
    • Hamanishi, J. et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc. Natl Acad. Sci. USA 104, 3360-3365 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 3360-3365
    • Hamanishi, J.1
  • 239
    • 61549122071 scopus 로고    scopus 로고
    • Overexpression of PD L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma
    • Gao, Q. et al. Overexpression of PD L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin. Cancer Res. 15, 971-979 (2009).
    • (2009) Clin. Cancer Res , vol.15 , pp. 971-979
    • Gao, Q.1
  • 240
    • 5844264920 scopus 로고    scopus 로고
    • PD L2 is a second ligand for PD 1 and inhibits T cell activation
    • Latchman, Y. et al. PD L2 is a second ligand for PD 1 and inhibits T cell activation. Nat. Immunol. 2, 261-268 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 261-268
    • Latchman, Y.1
  • 241
    • 84914695751 scopus 로고    scopus 로고
    • Expression of programmed cell death 1 ligand 2 (PD L2) is a distinguishing feature of primary mediastinal (thymic) large B cell lymphoma and associated with PDCD1LG2 copy gain
    • Shi, M. et al. Expression of programmed cell death 1 ligand 2 (PD L2) is a distinguishing feature of primary mediastinal (thymic) large B cell lymphoma and associated with PDCD1LG2 copy gain. Am. J. Surg. Pathol. 38, 1715-1723 (2014).
    • (2014) Am. J. Surg. Pathol , vol.38 , pp. 1715-1723
    • Shi, M.1
  • 242
    • 33745605153 scopus 로고    scopus 로고
    • B7 H3 and B7 H4 expression in non-small-cell lung cancer
    • Sun, Y. et al. B7 H3 and B7 H4 expression in non-small-cell lung cancer. Lung Cancer 53, 143-151 (2006).
    • (2006) Lung Cancer , vol.53 , pp. 143-151
    • Sun, Y.1
  • 243
    • 33644689145 scopus 로고    scopus 로고
    • Relationship between co stimulatory molecule B7 H3 expression and gastric carcinoma histology and prognosis
    • Wu, C. P. et al. Relationship between co stimulatory molecule B7 H3 expression and gastric carcinoma histology and prognosis. World J. Gastroenterol. 12, 457-459 (2006).
    • (2006) World J. Gastroenterol , vol.12 , pp. 457-459
    • Wu, C.P.1
  • 244
    • 52649160243 scopus 로고    scopus 로고
    • Tumor cell and tumor vasculature expression of B7 H3 predict survival in clear cell renal cell carcinoma
    • Crispen, P. L. et al. Tumor cell and tumor vasculature expression of B7 H3 predict survival in clear cell renal cell carcinoma. Clin. Cancer Res. 14, 5150-5157 (2008).
    • (2008) Clin. Cancer Res , vol.14 , pp. 5150-5157
    • Crispen, P.L.1
  • 245
    • 74549182599 scopus 로고    scopus 로고
    • Expression of the costimulatory molecule B7 H3 is associated with prolonged survival in human pancreatic cancer
    • Loos, M. et al. Expression of the costimulatory molecule B7 H3 is associated with prolonged survival in human pancreatic cancer. BMC Cancer 9, 463 (2009).
    • (2009) BMC Cancer , vol.9 , pp. 463
    • Loos, M.1
  • 246
    • 77953229339 scopus 로고    scopus 로고
    • Clinical significance and regulation of the costimulatory molecule B7 H3 in human colorectal carcinoma
    • Sun, J. et al. Clinical significance and regulation of the costimulatory molecule B7 H3 in human colorectal carcinoma. Cancer Immunol. Immunother. 59, 1163- 1171 (2010).
    • (2010) Cancer Immunol. Immunother , vol.59 , pp. 1163-1171
    • Sun, J.1
  • 247
    • 77955172320 scopus 로고    scopus 로고
    • Tumor associated endothelial expression of B7 H3 predicts survival in ovarian carcinomas
    • Zang, X. et al. Tumor associated endothelial expression of B7 H3 predicts survival in ovarian carcinomas. Mod. Pathol. 23, 1104-1112 (2010).
    • (2010) Mod. Pathol , vol.23 , pp. 1104-1112
    • Zang, X.1
  • 248
    • 34548046956 scopus 로고    scopus 로고
    • B7 H3 ligand expression by prostate cancer: A novel marker of prognosis and potential target for therapy
    • Roth, T. J. et al. B7 H3 ligand expression by prostate cancer: a novel marker of prognosis and potential target for therapy. Cancer Res. 67, 7893-7900 (2007).
    • (2007) Cancer Res , vol.67 , pp. 7893-7900
    • Roth, T.J.1
  • 249
    • 51049096135 scopus 로고    scopus 로고
    • T cell coregulatory molecule expression in urothelial cell carcinoma: Clinicopathologic correlations and association with survival
    • Boorjian, S. A. et al. T cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival. Clin. Cancer Res. 14, 4800-4808 (2008).
    • (2008) Clin. Cancer Res , vol.14 , pp. 4800-4808
    • Boorjian, S.A.1
  • 250
    • 16344391363 scopus 로고    scopus 로고
    • B7 H4 is highly expressed in ductal and lobular breast cancer
    • Tringler, B. et al. B7 H4 is highly expressed in ductal and lobular breast cancer. Clin. Cancer Res. 11, 1842-1848 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 1842-1848
    • Tringler, B.1
  • 251
    • 33745886516 scopus 로고    scopus 로고
    • B7 H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival
    • Krambeck, A. E. et al. B7 H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. Proc. Natl Acad. Sci. USA 103, 10391-10396 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 10391-10396
    • Krambeck, A.E.1
  • 252
    • 33645853780 scopus 로고    scopus 로고
    • B7 H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
    • Kryczek, I. et al. B7 H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J. Exp. Med. 203, 871-881 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 871-881
    • Kryczek, I.1
  • 253
    • 32944472874 scopus 로고    scopus 로고
    • B7 H4 is a novel membrane-bound protein and a candidate serum and tissue biomarker for ovarian cancer
    • Simon, I. et al. B7 H4 is a novel membrane-bound protein and a candidate serum and tissue biomarker for ovarian cancer. Cancer Res. 66, 1570-1575 (2006).
    • (2006) Cancer Res , vol.66 , pp. 1570-1575
    • Simon, I.1
  • 254
    • 29144453266 scopus 로고    scopus 로고
    • B7 H4 overexpression in ovarian tumors
    • Tringler, B. et al. B7 H4 overexpression in ovarian tumors. Gynecol. Oncol. 100, 44-52 (2006).
    • (2006) Gynecol. Oncol , vol.100 , pp. 44-52
    • Tringler, B.1
  • 255
    • 79959708884 scopus 로고    scopus 로고
    • B7 H4 expression associates with cancer progression and predicts patient's survival in human esophageal squamous cell carcinoma
    • Chen, L. J. et al. B7 H4 expression associates with cancer progression and predicts patient's survival in human esophageal squamous cell carcinoma. Cancer Immunol. Immunother. 60, 1047-1055 (2011).
    • (2011) Cancer Immunol. Immunother , vol.60 , pp. 1047-1055
    • Chen, L.J.1
  • 256
    • 80052261930 scopus 로고    scopus 로고
    • Clinical significance of the B7 H4 coregulatory molecule as a novel prognostic marker in gastric cancer
    • Arigami, T. et al. Clinical significance of the B7 H4 coregulatory molecule as a novel prognostic marker in gastric cancer. World J. Surg. 35, 2051-2057 (2011).
    • (2011) World J. Surg , vol.35 , pp. 2051-2057
    • Arigami, T.1
  • 257
    • 77958067744 scopus 로고    scopus 로고
    • Tumor expression of B7 H4 predicts poor survival of patients suffering from gastric cancer
    • Jiang, J. et al. Tumor expression of B7 H4 predicts poor survival of patients suffering from gastric cancer. Cancer Immunol. Immunother. 59, 1707-1714 (2010).
    • (2010) Cancer Immunol. Immunother , vol.59 , pp. 1707-1714
    • Jiang, J.1
  • 259
    • 45549085243 scopus 로고    scopus 로고
    • Detection of B7 H4 and p53 in pancreatic cancer: Potential role as a cytological diagnostic adjunct
    • Awadallah, N. S. et al. Detection of B7 H4 and p53 in pancreatic cancer: potential role as a cytological diagnostic adjunct. Pancreas 36, 200-206 (2008).
    • (2008) Pancreas , vol.36 , pp. 200-206
    • Awadallah, N.S.1
  • 260
    • 79956027063 scopus 로고    scopus 로고
    • B7 H4 expression in human melanoma: Its association with patients' survival and antitumor immune response
    • Quandt, D., Fiedler, E., Boettcher, D., Marsch, W. & Seliger, B. B7 H4 expression in human melanoma: its association with patients' survival and antitumor immune response. Clin. Cancer Res. 17, 3100-3111 (2011).
    • (2011) Clin. Cancer Res , vol.17 , pp. 3100-3111
    • Quandt, D.1    Fiedler, E.2    Boettcher, D.3    Marsch, W.4    Seliger, B.5
  • 261
    • 84907435684 scopus 로고    scopus 로고
    • Galectin expression profiling identifies galectin 1 and galectin 9d5 as prognostic factors in stage I/II non-small cell lung cancer
    • Schulkens, I. A. et al. Galectin expression profiling identifies galectin 1 and galectin 9d5 as prognostic factors in stage I/II non-small cell lung cancer. PLoS ONE 9, e107988 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e107988
    • Schulkens, I.A.1
  • 262
    • 0035017215 scopus 로고    scopus 로고
    • Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT PCR and its implications for diagnostic and therapeutic procedures
    • Lahm, H. et al. Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT PCR and its implications for diagnostic and therapeutic procedures. J. Cancer Res. Clin. Oncol. 127, 375-386 (2001).
    • (2001) J. Cancer Res. Clin. Oncol , vol.127 , pp. 375-386
    • Lahm, H.1
  • 263
    • 0026172015 scopus 로고
    • Lactose-binding lectin expression in human colorectal carcinomas
    • Lotan, R. et al. Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression. Carbohydr. Res. 213, 47-57 (1991).
    • (1991) Relation to Tumor Progression. Carbohydr. Res , vol.213 , pp. 47-57
    • Lotan, R.1
  • 264
    • 0036835054 scopus 로고    scopus 로고
    • Increased expression of galectin 3 in primary gastric cancer and the metastatic lymph nodes
    • Miyazaki, J. et al. Increased expression of galectin 3 in primary gastric cancer and the metastatic lymph nodes. Oncol. Rep. 9, 1307-1312 (2002).
    • (2002) Oncol. Rep , vol.9 , pp. 1307-1312
    • Miyazaki, J.1
  • 265
    • 0024267631 scopus 로고
    • Ki 1 (CD30) antigen is regularly expressed by tumor cells of embryonal carcinoma
    • Pallesen, G. & Hamilton-Dutoit, S. J. Ki 1 (CD30) antigen is regularly expressed by tumor cells of embryonal carcinoma. Am. J. Pathol. 133, 446-450 (1988).
    • (1988) Am. J. Pathol , vol.133 , pp. 446-450
    • Pallesen, G.1    Hamilton-Dutoit, S.J.2
  • 266
    • 84864290155 scopus 로고    scopus 로고
    • CD70 expression patterns in renal cell carcinoma
    • Jilaveanu, L. B. et al. CD70 expression patterns in renal cell carcinoma. Hum. Pathol. 43, 1394-1399 (2012).
    • (2012) Hum. Pathol , vol.43 , pp. 1394-1399
    • Jilaveanu, L.B.1
  • 267
    • 34948875291 scopus 로고    scopus 로고
    • CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25 T cells
    • Yang, Z. Z., Novak, A. J., Ziesmer, S. C., Witzig, T. E. & Ansell, S. M. CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25 T cells. Blood 110, 2537-2544 (2007).
    • (2007) Blood , vol.110 , pp. 2537-2544
    • Yang, Z.Z.1    Novak, A.J.2    Ziesmer, S.C.3    Witzig, T.E.4    Ansell, S.M.5
  • 268
    • 0344444313 scopus 로고    scopus 로고
    • Expression of the B7 related molecule ICOSL by human glioma cells in vitro and in vivo
    • Schreiner, B. et al. Expression of the B7 related molecule ICOSL by human glioma cells in vitro and in vivo. Glia 44, 296-301 (2003).
    • (2003) Glia , vol.44 , pp. 296-301
    • Schreiner, B.1
  • 269
    • 78649941232 scopus 로고    scopus 로고
    • Melanoma cells express ICOS ligand to promote the activation and expansion of T regulatory cells
    • Martin-Orozco, N. et al. Melanoma cells express ICOS ligand to promote the activation and expansion of T regulatory cells. Cancer Res. 70, 9581-9590 (2010).
    • (2010) Cancer Res , vol.70 , pp. 9581-9590
    • Martin-Orozco, N.1
  • 270
    • 13144299338 scopus 로고    scopus 로고
    • CD155/PVR plays a key role in cell motility during tumor cell invasion and migration
    • Sloan, K. E. et al. CD155/PVR plays a key role in cell motility during tumor cell invasion and migration. BMC Cancer 4, 73 (2004)
    • (2004) BMC Cancer , vol.4 , pp. 73
    • Sloan, K.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.