메뉴 건너뛰기




Volumn 84, Issue 9-10, 2018, Pages 568-583

Aspalathin from Rooibos (Aspalathus linearis): A Bioactive C -glucosyl Dihydrochalcone with Potential to Target the Metabolic Syndrome

Author keywords

aspalathin; Aspalathus linearis; bioavailability; Fabaceae; herb drug interactions; metabolic syndrome; molecular mechanism; oxidative stress

Indexed keywords

ASPALATHIN; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; ANTIOXIDANT; CHALCONE DERIVATIVE; DIHYDROCHALCONE;

EID: 85041588772     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0044-100622     Document Type: Review
Times cited : (64)

References (168)
  • 1
    • 0000577250 scopus 로고
    • Phlorhizin glucosuria
    • McKee F. Hawkins B. Phlorhizin glucosuria. Physiol Rev: 1945; 25 255 280
    • (1945) Physiol Rev , vol.25 , pp. 255-280
    • McKee, F.1    Hawkins, B.2
  • 2
    • 0001829799 scopus 로고
    • Geissman T. ed. The Chemistry of flavonoid Compounds London, UK Pergamon Press
    • Swain T. Economic Importance of flavonoid Compounds: Foodstuffs. In: Geissman T. ed. The Chemistry of flavonoid Compounds. London, UK Pergamon Press: 1962; 513 552
    • (1962) Economic Importance of Flavonoid Compounds: Foodstuffs , pp. 513-552
    • Swain, T.1
  • 3
    • 58149357463 scopus 로고    scopus 로고
    • Sodium-glucose co-transporter-2 inhibitors: An emerging new class of oral antidiabetic drug
    • Idris I. Donnelly R. Sodium-glucose co-transporter-2 inhibitors: an emerging new class of oral antidiabetic drug. Diabetes Obes Metab: 2009; 11 79 88
    • (2009) Diabetes Obes Metab , vol.11 , pp. 79-88
    • Idris, I.1    Donnelly, R.2
  • 4
    • 85010644658 scopus 로고    scopus 로고
    • Targeting type 2 diabetes with C -glucosyl dihydrochalcones as selective sodium glucose co-transporter 2 (SGLT2) inhibitors: Synthesis and biological evaluation
    • Jesus A. R. Vila-Viçosa D. Machuqueiro M. Marques A. P. Dore T. M. Rauter A. P. Targeting type 2 diabetes with C -glucosyl dihydrochalcones as selective sodium glucose co-transporter 2 (SGLT2) inhibitors: synthesis and biological evaluation. J Med Chem: 2017; 60 568 579
    • (2017) J Med Chem , vol.60 , pp. 568-579
    • Jesus, A.R.1    Vila-Viçosa, D.2    Machuqueiro, M.3    Marques, A.P.4    Dore, T.M.5    Rauter, A.P.6
  • 5
    • 85017460512 scopus 로고    scopus 로고
    • Natural products as lead compounds for sodium glucose cotransporter (SGLT) inhibitors
    • Blaschek W. Natural products as lead compounds for sodium glucose cotransporter (SGLT) inhibitors. Planta Med: 2017; 83 985 993
    • (2017) Planta Med , vol.83 , pp. 985-993
    • Blaschek, W.1
  • 6
    • 84955187389 scopus 로고    scopus 로고
    • In silico modeling of aspalathin and nothofagin against SGLT2
    • Liu W. Wang H. Meng F. In silico modeling of aspalathin and nothofagin against SGLT2. J Theor Comput Chem: 2015; 14 1550056
    • (2015) J Theor Comput Chem , vol.14 , pp. 1550056
    • Liu, W.1    Wang, H.2    Meng, F.3
  • 8
    • 85048916114 scopus 로고    scopus 로고
    • Accessed September 13, 2017
    • Chemspider CSID: 9457391. Available at. http://www.chemspider.com/Chemical-Structure9457391.html Accessed September 13, 2017
    • Chemspider CSID: 9457391
  • 9
    • 0007793672 scopus 로고
    • Aspalathin: A novel C -glycosylflavonoid from Aspalathus linearis
    • Koeppen B. H. Roux D. G. Aspalathin: a novel C -glycosylflavonoid from Aspalathus linearis. Tetrahedron Lett: 1965; 39 3497 3503
    • (1965) Tetrahedron Lett , vol.39 , pp. 3497-3503
    • Koeppen, B.H.1    Roux, D.G.2
  • 11
    • 44149111085 scopus 로고    scopus 로고
    • Transport of aspalathin, a rooibos tea flavonoid, across the skin and intestinal epithelium
    • Huang M. Du Plessis J. Du Preez J. Hamman J. Viljoen A. Transport of aspalathin, a rooibos tea flavonoid, across the skin and intestinal epithelium. Phyther Res: 2008; 22 699 704
    • (2008) Phyther Res , vol.22 , pp. 699-704
    • Huang, M.1    Du Plessis, J.2    Du Preez, J.3    Hamman, J.4    Viljoen, A.5
  • 13
    • 0000041472 scopus 로고
    • Revision of the genus Aspalathus. II. the species with ericoid and pinoid leaflets. 7. Subgenus Nortieria. with remarks on rooibos tea cultivation
    • Dahlgren R. Revision of the genus Aspalathus. II. The species with ericoid and pinoid leaflets. 7. Subgenus Nortieria. With remarks on rooibos tea cultivation. Bot Not: 1968; 121 165 208
    • (1968) Bot Not , vol.121 , pp. 165-208
    • Dahlgren, R.1
  • 14
    • 0038611972 scopus 로고
    • Crotalarieae (Aspalathus)
    • Dahlgren R. Crotalarieae (Aspalathus). Flora South Africa: 1988; 16 84 90
    • (1988) Flora South Africa , vol.16 , pp. 84-90
    • Dahlgren, R.1
  • 15
    • 85035794358 scopus 로고    scopus 로고
    • Analysis of phenolic compounds in rooibos tea (Aspalathus linearis) with a comparison of flavonoid-based compounds in natural populations of plants from different regions
    • Stander M. Van Wyk B. Taylor M. JC. Long H. S. Analysis of phenolic compounds in rooibos tea (Aspalathus linearis) with a comparison of flavonoid-based compounds in natural populations of plants from different regions. J Agric Food Chem: 2017; 65 10270 10281
    • (2017) J Agric Food Chem , vol.65 , pp. 10270-10281
    • Stander, M.1    Van Wyk, B.2    Taylor, M.J.3    Long, H.S.4
  • 16
    • 85008219785 scopus 로고    scopus 로고
    • The history and ethnobotany of Cape herbal teas
    • Van Wyk B. E. Gorelik B. The history and ethnobotany of Cape herbal teas. South African J Bot: 2017; 110 18 38
    • (2017) South African J Bot , vol.110 , pp. 18-38
    • Van Wyk, B.E.1    Gorelik, B.2
  • 17
    • 71349084986 scopus 로고    scopus 로고
    • Distribution, quantitative morphological variation and preliminary molecular analysis of different growth forms of wild rooibos (Aspalathus linearis) in the northern Cederberg and on the Bokkeveld Plateau
    • Malgas R. R. Potts A. J. Oettlé N. M. Koelle B. Todd S. W. Verboom G. A. Hoffman M. T. Distribution, quantitative morphological variation and preliminary molecular analysis of different growth forms of wild rooibos (Aspalathus linearis) in the northern Cederberg and on the Bokkeveld Plateau. South African J Bot: 2010; 76 72 81
    • (2010) South African J Bot , vol.76 , pp. 72-81
    • Malgas, R.R.1    Potts, A.J.2    Oettlé, N.M.3    Koelle, B.4    Todd, S.W.5    Verboom, G.A.6    Hoffman, M.T.7
  • 18
    • 79955469784 scopus 로고    scopus 로고
    • Ecotypes of wild rooibos (Aspalathus linearis (Burm. F) Dahlg., Fabaceae) are ecologically distinct
    • Hawkins H. J. Malgas R. Biénabe E. Ecotypes of wild rooibos (Aspalathus linearis (Burm. F) Dahlg., Fabaceae) are ecologically distinct. South African J Bot: 2011; 77 360 370
    • (2011) South African J Bot , vol.77 , pp. 360-370
    • Hawkins, H.J.1    Malgas, R.2    Biénabe, E.3
  • 20
    • 33845481833 scopus 로고    scopus 로고
    • Production and quality aspects of rooibos tea and related products. A review
    • Joubert E. Schulz H. Production and quality aspects of rooibos tea and related products. A review. J Appl Bot Food Qual: 2006; 80 138 144
    • (2006) J Appl Bot Food Qual , vol.80 , pp. 138-144
    • Joubert, E.1    Schulz, H.2
  • 21
    • 84867009097 scopus 로고    scopus 로고
    • Occurrence and sensory perception of Z -2-(β -D-glucopyranosyloxy)-3-phenylpropenoic acid in rooibos (Aspalathus linearis)
    • Joubert E. De Beer D. Malherbe C. J. Muller N. Bonnet S. L. Van der Westhuizen J. H. Ferreira D. Occurrence and sensory perception of Z -2-(β -D-glucopyranosyloxy)-3-phenylpropenoic acid in rooibos (Aspalathus linearis). Food Chem: 2013; 136 1078 1085
    • (2013) Food Chem , vol.136 , pp. 1078-1085
    • Joubert, E.1    De Beer, D.2    Malherbe, C.J.3    Muller, N.4    Bonnet, S.L.5    Van Dar Westhuizen, J.H.6    Ferreira, D.7
  • 22
    • 81255160750 scopus 로고    scopus 로고
    • Rooibos (Aspalathus linearis) beyond the farm gate: From herbal tea to potential phytopharmaceutical
    • Joubert E. De Beer D. Rooibos (Aspalathus linearis) beyond the farm gate: From herbal tea to potential phytopharmaceutical. South African J Bot: 2011; 77 869 886
    • (2011) South African J Bot , vol.77 , pp. 869-886
    • Joubert, E.1    De Beer, D.2
  • 23
    • 84863396521 scopus 로고    scopus 로고
    • Sensory characterization of rooibos tea and the development of a rooibos sensory wheel and lexicon
    • Koch I. S. Muller M. Joubert E. Van der Rijst M. Næs T. Sensory characterization of rooibos tea and the development of a rooibos sensory wheel and lexicon. Food Res Int: 2012; 46 217 228
    • (2012) Food Res Int , vol.46 , pp. 217-228
    • Koch, I.S.1    Muller, M.2    Joubert, E.3    Van Dar Rijst, M.4
  • 24
    • 84994128795 scopus 로고    scopus 로고
    • Sensory profile of rooibos originating from the Western and Northern Cape governed by production year and development of rooibos aroma wheel
    • Jolley B. Van der Rijst M. Joubert E. Muller M. Sensory profile of rooibos originating from the Western and Northern Cape governed by production year and development of rooibos aroma wheel. South African J Bot: 2017; 110 161 166
    • (2017) South African J Bot , vol.110 , pp. 161-166
    • Jolley, B.1    Van Dar Rijst, M.2    Joubert, E.3    Muller, M.4
  • 25
    • 84959906140 scopus 로고    scopus 로고
    • Production of dihydrochalcone-rich green rooibos (Aspalathus linearis) extract taking into account seasonal and batch-to-batch variation in phenolic composition of plant material
    • De Beer D. Miller N. Joubert E. Production of dihydrochalcone-rich green rooibos (Aspalathus linearis) extract taking into account seasonal and batch-to-batch variation in phenolic composition of plant material. South African J Bot: 2017; 110 138 143
    • (2017) South African J Bot , vol.110 , pp. 138-143
    • De Beer, D.1    Miller, N.2    Joubert, E.3
  • 26
    • 84863992380 scopus 로고    scopus 로고
    • Phenolic content and antioxidant activity of rooibos food ingredient extracts
    • Joubert E. De Beer D. Phenolic content and antioxidant activity of rooibos food ingredient extracts. J Food Compos Anal: 2012; 27 45 51
    • (2012) J Food Compos Anal , vol.27 , pp. 45-51
    • Joubert, E.1    De Beer, D.2
  • 27
    • 84997684101 scopus 로고    scopus 로고
    • Identification of broad-based sensory attributes driving consumer preference of ready-to-drink rooibos iced tea with increased aspalathin content
    • Viljoen M. Muller M. De Beer D. Joubert E. Identification of broad-based sensory attributes driving consumer preference of ready-to-drink rooibos iced tea with increased aspalathin content. South African J Bot: 2017; 110 177 183
    • (2017) South African J Bot , vol.110 , pp. 177-183
    • Viljoen, M.1    Muller, M.2    De Beer, D.3    Joubert, E.4
  • 28
    • 85014121892 scopus 로고    scopus 로고
    • Potential of rooibos, its major C -glucosyl flavonoids and Z -2-(β -D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention of metabolic syndrome
    • Muller C. JF. Malherbe C. J. Chellan N. Yagasaki K. Miura Y. Joubert E. Potential of rooibos, its major C -glucosyl flavonoids and Z -2-(β -D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention of metabolic syndrome. Crit Rev Food Sci Nutr: 2018; 58 227 246
    • (2018) Crit Rev Food Sci Nutr , vol.58 , pp. 227-246
    • Muller, C.J.1    Malherbe, C.J.2    Chellan, N.3    Yagasaki, K.4    Miura, Y.5    Joubert, E.6
  • 29
    • 84866431357 scopus 로고    scopus 로고
    • Variation in phenolic content and antioxidant activity of fermented rooibos herbal tea infusions: Role of production season and quality grade
    • Joubert E. Beelders T. De Beer D. Malherbe C. J. De Villiers A. Sigge G. O. Variation in phenolic content and antioxidant activity of fermented rooibos herbal tea infusions: role of production season and quality grade. J Agric Food Chem: 2012; 60 9171 9179
    • (2012) J Agric Food Chem , vol.60 , pp. 9171-9179
    • Joubert, E.1    Beelders, T.2    De Beer, D.3    Malherbe, C.J.4    De Villiers, A.5    Sigge, G.O.6
  • 30
    • 84922781289 scopus 로고    scopus 로고
    • Isolation of aspalathin and nothofagin from rooibos (Aspalathus linearis) using high-performance countercurrent chromatography: Sample loading and compound stability considerations
    • De Beer D. Malherbe C. J. Beelders T. Willenburg E. L. Brand D. J. Joubert E. Isolation of aspalathin and nothofagin from rooibos (Aspalathus linearis) using high-performance countercurrent chromatography: sample loading and compound stability considerations. J Chromatogr A: 2015; 1381 29 36
    • (2015) J Chromatogr A , vol.1381 , pp. 29-36
    • De Beer, D.1    Malherbe, C.J.2    Beelders, T.3    Willenburg, E.L.4    Brand, D.J.5    Joubert, E.6
  • 31
    • 0029914342 scopus 로고    scopus 로고
    • HPLC quantification of the dihydrochalcones, aspalathin and nothofagin in rooibos tea (Aspalathus linearis) as affected by processing
    • Joubert E. HPLC quantification of the dihydrochalcones, aspalathin and nothofagin in rooibos tea (Aspalathus linearis) as affected by processing. Food Chem: 1996; 55 403 411
    • (1996) Food Chem , vol.55 , pp. 403-411
    • Joubert, E.1
  • 32
    • 0037174458 scopus 로고    scopus 로고
    • Quantitative characterization of flavonoid compounds in rooibos tea (Aspalathus linearis) by LC-UV/DAD
    • Bramati L. Minoggio M. Gardana C. Simonetti P. Mauri P. Pietta P. Quantitative characterization of flavonoid compounds in rooibos tea (Aspalathus linearis) by LC-UV/DAD. J Agric Food Chem: 2002; 50 5513 5519
    • (2002) J Agric Food Chem , vol.50 , pp. 5513-5519
    • Bramati, L.1    Minoggio, M.2    Gardana, C.3    Simonetti, P.4    Mauri, P.5    Pietta, P.6
  • 33
    • 79955618009 scopus 로고    scopus 로고
    • Bioavailability and antioxidant potential of rooibos flavonoids in humans following the consumption of different rooibos formulations
    • Breiter T. Laue C. Kressel G. Gröll S. Engelhardt U. H. Hahn A. Bioavailability and antioxidant potential of rooibos flavonoids in humans following the consumption of different rooibos formulations. Food Chem: 2011; 128 338 347
    • (2011) Food Chem , vol.128 , pp. 338-347
    • Breiter, T.1    Laue, C.2    Kressel, G.3    Gröll, S.4    Engelhardt, U.H.5    Hahn, A.6
  • 34
    • 84355165233 scopus 로고    scopus 로고
    • Kinetic optimisation of the reversed phase liquid chromatographic separation of rooibos tea (Aspalathus linearis) phenolics on conventional high performance liquid chromatographic instrumentation
    • Beelders T. Sigge G. O. Joubert E. De Beer D. De Villiers A. Kinetic optimisation of the reversed phase liquid chromatographic separation of rooibos tea (Aspalathus linearis) phenolics on conventional high performance liquid chromatographic instrumentation. J Chromatogr A: 2012; 1219 128 139
    • (2012) J Chromatogr A , vol.1219 , pp. 128-139
    • Beelders, T.1    Sigge, G.O.2    Joubert, E.3    De Beer, D.4    De Villiers, A.5
  • 35
    • 1242297266 scopus 로고    scopus 로고
    • Quantification of quality parameters for reliable evaluation of green rooibos (Aspalathus linearis)
    • Schulz H. Joubert E. Schütze W. Quantification of quality parameters for reliable evaluation of green rooibos (Aspalathus linearis). Eur Food Res Technol: 2003; 216 539 543
    • (2003) Eur Food Res Technol , vol.216 , pp. 539-543
    • Schulz, H.1    Joubert, E.2    Schütze, W.3
  • 36
    • 68249108404 scopus 로고    scopus 로고
    • Bioavailability of C -linked dihydrochalcone and flavanone glucosides in humans following ingestion of unfermented and fermented rooibos teas
    • Stalmach A. Mullen W. Pecorari M. Serafini M. Crozier A. Bioavailability of C -linked dihydrochalcone and flavanone glucosides in humans following ingestion of unfermented and fermented rooibos teas. J Agric Food Chem: 2009; 57 7104 7111
    • (2009) J Agric Food Chem , vol.57 , pp. 7104-7111
    • Stalmach, A.1    Mullen, W.2    Pecorari, M.3    Serafini, M.4    Crozier, A.5
  • 37
    • 85000796441 scopus 로고    scopus 로고
    • Improved HPLC method for rooibos phenolics targeting changes due to fermentation
    • Walters N. A. De Villiers A. Joubert E. De Beer D. Improved HPLC method for rooibos phenolics targeting changes due to fermentation. J Food Compos Anal: 2017; 55 20 29
    • (2017) J Food Compos Anal , vol.55 , pp. 20-29
    • Walters, N.A.1    De Villiers, A.2    Joubert, E.3    De Beer, D.4
  • 38
    • 27944473041 scopus 로고    scopus 로고
    • Mass spectrometric identification and quantification of glycosyl flavonoids, including dihydrochalcones with neutral loss scan mode
    • Kazuno S. Yanagida M. Shindo N. Murayama K. Mass spectrometric identification and quantification of glycosyl flavonoids, including dihydrochalcones with neutral loss scan mode. Anal Biochem: 2005; 347 182 192
    • (2005) Anal Biochem , vol.347 , pp. 182-192
    • Kazuno, S.1    Yanagida, M.2    Shindo, N.3    Murayama, K.4
  • 39
    • 85015818788 scopus 로고    scopus 로고
    • Evaluation of capillary electrophoresis for the analysis of rooibos and honeybush tea phenolics
    • Arries W. J. Tredoux A. G. De Beer D. Joubert E. De Villiers A. Evaluation of capillary electrophoresis for the analysis of rooibos and honeybush tea phenolics. Electrophoresis: 2017; 38 897 905
    • (2017) Electrophoresis , vol.38 , pp. 897-905
    • Arries, W.J.1    Tredoux, A.G.2    De Beer, D.3    Joubert, E.4    De Villiers, A.5
  • 42
    • 0013914269 scopus 로고
    • C -glycosylflavonoids. the chemistry of aspalathin
    • Koeppen B. H. Roux D. G. C -glycosylflavonoids. The chemistry of aspalathin. Biochem J: 1966; 99 604 609
    • (1966) Biochem J , vol.99 , pp. 604-609
    • Koeppen, B.H.1    Roux, D.G.2
  • 44
    • 0034692456 scopus 로고    scopus 로고
    • (S)- and (R)-eriodictyol-6- C - β -D-glucopyranoside, novel keys to the fermentation of rooibos (Aspalathus linearis)
    • Marais C. Van Rensburg W. J. Ferreira D. Steenkamp J. A. (S)- and (R)-eriodictyol-6- C - β -D-glucopyranoside, novel keys to the fermentation of rooibos (Aspalathus linearis). Phytochemistry: 2000; 55 43 49
    • (2000) Phytochemistry , vol.55 , pp. 43-49
    • Marais, C.1    Van Rensburg, W.J.2    Ferreira, D.3    Steenkamp, J.A.4
  • 45
    • 44349088984 scopus 로고    scopus 로고
    • Characterization of phenolic compounds in rooibos tea
    • Krafczyk N. Glomb M. A. Characterization of phenolic compounds in rooibos tea. J Agric Food Chem: 2008; 56 3368 3376
    • (2008) J Agric Food Chem , vol.56 , pp. 3368-3376
    • Krafczyk, N.1    Glomb, M.A.2
  • 46
    • 68249098662 scopus 로고    scopus 로고
    • Oxidation of the dihydrochalcone aspalathin leads to dimerization
    • Krafczyk N. Heinrich T. Porzel A. Glomb M. A. Oxidation of the dihydrochalcone aspalathin leads to dimerization. J Agric Food Chem: 2009; 57 6838 6843
    • (2009) J Agric Food Chem , vol.57 , pp. 6838-6843
    • Krafczyk, N.1    Heinrich, T.2    Porzel, A.3    Glomb, M.A.4
  • 47
    • 84861440860 scopus 로고    scopus 로고
    • Chemistry of color formation during rooibos fermentation
    • Heinrich T. Willenberg I. Glomb M. A. Chemistry of color formation during rooibos fermentation. J Agric Food Chem: 2012; 60 5221 5228
    • (2012) J Agric Food Chem , vol.60 , pp. 5221-5228
    • Heinrich, T.1    Willenberg, I.2    Glomb, M.A.3
  • 48
    • 66149140507 scopus 로고    scopus 로고
    • Effect of heat on aspalathin, iso-orientin, and orientin contents and color of fermented rooibos (Aspalathus linearis) iced tea
    • Joubert E. Viljoen M. De Beer D. Manley M. Effect of heat on aspalathin, iso-orientin, and orientin contents and color of fermented rooibos (Aspalathus linearis) iced tea. J Agric Food Chem: 2009; 57 4204 4211
    • (2009) J Agric Food Chem , vol.57 , pp. 4204-4211
    • Joubert, E.1    Viljoen, M.2    De Beer, D.3    Manley, M.4
  • 50
    • 53449094758 scopus 로고    scopus 로고
    • South African herbal teas: Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides - A review
    • Joubert E. Gelderblom W. CA. Louw A. De Beer D. South African herbal teas: Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides - a review. J Ethnopharmacol: 2008; 119 376 412
    • (2008) J Ethnopharmacol , vol.119 , pp. 376-412
    • Joubert, E.1    Gelderblom, W.C.2    Louw, A.3    De Beer, D.4
  • 51
    • 78649636886 scopus 로고    scopus 로고
    • Basic biochemical mechanisms behind the health benefits of polyphenols
    • Fraga C. G. Galleano M. Verstraeten S. V. Oteiza P. I. Basic biochemical mechanisms behind the health benefits of polyphenols. Mol Aspects Med: 2010; 31 435 445
    • (2010) Mol Aspects Med , vol.31 , pp. 435-445
    • Fraga, C.G.1    Galleano, M.2    Verstraeten, S.V.3    Oteiza, P.I.4
  • 52
    • 1242322418 scopus 로고    scopus 로고
    • Superoxide anion and α,α -diphenyl- β -picrylhydrazyl radical scavenging capacity of rooibos (Aspalathus linearis) aqueous extracts, crude phenolic fractions, tannin and flavonoids
    • Joubert E. Winterton P. Britz T. J. Ferreira D. Superoxide anion and α,α -diphenyl- β -picrylhydrazyl radical scavenging capacity of rooibos (Aspalathus linearis) aqueous extracts, crude phenolic fractions, tannin and flavonoids. Food Res Int: 2004; 37 133 138
    • (2004) Food Res Int , vol.37 , pp. 133-138
    • Joubert, E.1    Winterton, P.2    Britz, T.J.3    Ferreira, D.4
  • 53
    • 30544447922 scopus 로고    scopus 로고
    • Antioxidant and pro-oxidant activities of aqueous extracts and crude polyphenolic fractions of rooibos (Aspalathus linearis)
    • Joubert E. Winterton P. Britz T. J. Gelderblom W. CA. Antioxidant and pro-oxidant activities of aqueous extracts and crude polyphenolic fractions of rooibos (Aspalathus linearis). J Agric Food Chem: 2005; 53 10260 10267
    • (2005) J Agric Food Chem , vol.53 , pp. 10260-10267
    • Joubert, E.1    Winterton, P.2    Britz, T.J.3    Gelderblom, W.C.4
  • 54
    • 68249084032 scopus 로고    scopus 로고
    • Antioxidant activity of the dihydrochalcones aspalathin and nothofagin and their corresponding flavones in relation to other rooibos (Aspalathus linearis) flavonoids, epigallocatechin gallate, and Trolox
    • Snijman P. W. Joubert E. Ferreira D. Li X. C. Ding Y. Green I. R. Gelderblom W. CA. Antioxidant activity of the dihydrochalcones aspalathin and nothofagin and their corresponding flavones in relation to other rooibos (Aspalathus linearis) flavonoids, epigallocatechin gallate, and Trolox. J Agric Food Chem: 2009; 57 6678 6684
    • (2009) J Agric Food Chem , vol.57 , pp. 6678-6684
    • Snijman, P.W.1    Joubert, E.2    Ferreira, D.3    Li, X.C.4    Ding, Y.5    Green, I.R.6    Gelderblom, W.C.7
  • 55
    • 0000956196 scopus 로고    scopus 로고
    • Comparison of the antioxidant activity of aspalathin with that of other plant phenols of rooibos tea (Aspalathus linearis), α -tocopherol, BHT, and BHA
    • Von Gadow A. Joubert E. Hansmann C. F. Comparison of the antioxidant activity of aspalathin with that of other plant phenols of rooibos tea (Aspalathus linearis), α -tocopherol, BHT, and BHA. J Agric Food Chem: 1997; 45 632 638
    • (1997) J Agric Food Chem , vol.45 , pp. 632-638
    • Von Gadow, A.1    Joubert, E.2    Hansmann, C.F.3
  • 56
    • 67649083956 scopus 로고    scopus 로고
    • Structure-antioxidant relationship of flavonoids from fermented rooibos
    • Krafczyk N. Woyand F. Glomb M. A. Structure-antioxidant relationship of flavonoids from fermented rooibos. Mol Nutr Food Res: 2009; 53 635 642
    • (2009) Mol Nutr Food Res , vol.53 , pp. 635-642
    • Krafczyk, N.1    Woyand, F.2    Glomb, M.A.3
  • 58
    • 84992374804 scopus 로고    scopus 로고
    • Anti-inflammatory effects of Aspalathus linearis and Cyclopia spp. Extracts in a UVB/keratinocyte (HaCaT) model utilising interleukin-1 α accumulation as biomarker
    • Magcwebeba T. Swart P. Swanevelder S. Joubert E. Gelderblom W. Anti-inflammatory effects of Aspalathus linearis and Cyclopia spp. extracts in a UVB/keratinocyte (HaCaT) model utilising interleukin-1 α accumulation as biomarker. Molecules: 2016; 21 E1323
    • (2016) Molecules , vol.21 , pp. E1323
    • Magcwebeba, T.1    Swart, P.2    Swanevelder, S.3    Joubert, E.4    Gelderblom, W.5
  • 59
    • 0036306766 scopus 로고    scopus 로고
    • The antioxidant activity of phloretin: The disclosure of a new antioxidant pharmacophore in flavonoids
    • Rezk B. M. Van der Vijgh W. JF. Bast A. The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids. Biochem Biophys Res Commun: 2002; 295 9 13
    • (2002) Biochem Biophys Res Commun , vol.295 , pp. 9-13
    • Rezk, B.M.1    Van Dar Vijgh, W.J.2    Bast, A.3
  • 60
    • 77950240519 scopus 로고    scopus 로고
    • Concise total syntheses of aspalathin and nothofagin
    • Yepremyan A. Salehani B. Minehan T. G. Concise total syntheses of aspalathin and nothofagin. Org Lett: 2010; 12 1580 1583
    • (2010) Org Lett , vol.12 , pp. 1580-1583
    • Yepremyan, A.1    Salehani, B.2    Minehan, T.G.3
  • 63
    • 85010471684 scopus 로고    scopus 로고
    • The concise synthesis and biological evaluation of C -glycosyl chalcone analogues inspired by the natural product aspalathin
    • Zhang T. Fang Z. The concise synthesis and biological evaluation of C -glycosyl chalcone analogues inspired by the natural product aspalathin. RSC Adv: 2017; 7 3021 3024
    • (2017) RSC Adv , vol.7 , pp. 3021-3024
    • Zhang, T.1    Fang, Z.2
  • 64
    • 84895115352 scopus 로고    scopus 로고
    • Leloir glycosyltransferases and natural product glycosylation: Biocatalytic synthesis of the C -glucoside nothofagin, a major antioxidant of redbush herbal tea
    • Bungaruang L. Gutmann A. Nidetzky B. Leloir glycosyltransferases and natural product glycosylation: Biocatalytic synthesis of the C -glucoside nothofagin, a major antioxidant of redbush herbal tea. Adv Synth Catal: 2013; 355 2757 2763
    • (2013) Adv Synth Catal , vol.355 , pp. 2757-2763
    • Bungaruang, L.1    Gutmann, A.2    Nidetzky, B.3
  • 65
    • 84956783882 scopus 로고    scopus 로고
    • β -Cyclodextrin improves solubility and enzymatic C -glucosylation of the flavonoid phloretin
    • Bungaruang L. Gutmann A. Nidetzky B. β -Cyclodextrin improves solubility and enzymatic C -glucosylation of the flavonoid phloretin. Adv Synth Catal: 2016; 358 486 493
    • (2016) Adv Synth Catal , vol.358 , pp. 486-493
    • Bungaruang, L.1    Gutmann, A.2    Nidetzky, B.3
  • 66
    • 85009935517 scopus 로고    scopus 로고
    • Metabolic engineering of Saccharomyces cerevisiae for de novo production of dihydrochalcones with known antioxidant, antidiabetic, and sweet tasting properties
    • Eichenberger M. Lehka B. J. Folly C. Fischer D. Martens S. Simón E. Naesby M. Metabolic engineering of Saccharomyces cerevisiae for de novo production of dihydrochalcones with known antioxidant, antidiabetic, and sweet tasting properties. Metab Eng: 2017; 39 80 89
    • (2017) Metab Eng , vol.39 , pp. 80-89
    • Eichenberger, M.1    Lehka, B.J.2    Folly, C.3    Fischer, D.4    Martens, S.5    Simón, E.6    Naesby, M.7
  • 67
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski C. A. Lombardo F. Dominy B. W. Feeney P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev: 1997; 23 3 25
    • (1997) Adv Drug Deliv Rev , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 68
    • 0037523454 scopus 로고    scopus 로고
    • Profiling drug-like properties in discovery research
    • Di L. Kerns E. H. Profiling drug-like properties in discovery research. Curr Opin Chem Biol: 2003; 7 402 408
    • (2003) Curr Opin Chem Biol , vol.7 , pp. 402-408
    • Di, L.1    Kerns, E.H.2
  • 69
    • 0037030653 scopus 로고    scopus 로고
    • Molecular properties that influence the oral bioavailability of drug candidates
    • Veber D. F. Johnson S. R. Cheng H. Y. Smith B. R. Ward K. W. Kopple K. D. Molecular properties that influence the oral bioavailability of drug candidates. J Med Chem: 2002; 45 2615 2623
    • (2002) J Med Chem , vol.45 , pp. 2615-2623
    • Veber, D.F.1    Johnson, S.R.2    Cheng, H.Y.3    Smith, B.R.4    Ward, K.W.5    Kopple, K.D.6
  • 70
    • 84971514027 scopus 로고    scopus 로고
    • The occurrence, fate and biological activities of C -glycosyl flavonoids in the human diet
    • Courts F. L. Williamson G. The occurrence, fate and biological activities of C -glycosyl flavonoids in the human diet. Crit Rev Food Sci Nutr: 2015; 10 1352 1367
    • (2015) Crit Rev Food Sci Nutr , vol.10 , pp. 1352-1367
    • Courts, F.L.1    Williamson, G.2
  • 71
    • 77249093563 scopus 로고    scopus 로고
    • In vitro hepatic biotransformation of aspalathin and nothofagin, dihydrochalcones of rooibos (Aspalathus linearis), and assessment of metabolite antioxidant activity
    • Van der Merwe J. D. Joubert E. Manley M. De Beer D. Malherbe C. J. Gelderblom W. CA. In vitro hepatic biotransformation of aspalathin and nothofagin, dihydrochalcones of rooibos (Aspalathus linearis), and assessment of metabolite antioxidant activity. J Agric Food Chem: 2010; 58 2214 2220
    • (2010) J Agric Food Chem , vol.58 , pp. 2214-2220
    • Van Dar Merwe, J.D.1    Joubert, E.2    Manley, M.3    De Beer, D.4    Malherbe, C.J.5    Gelderblom, W.C.6
  • 72
    • 70349634169 scopus 로고    scopus 로고
    • The C -glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans
    • Courts F. L. Williamson G. The C -glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans. Mol Nutr Food Res: 2009; 53 1104 1111
    • (2009) Mol Nutr Food Res , vol.53 , pp. 1104-1111
    • Courts, F.L.1    Williamson, G.2
  • 73
    • 53449087260 scopus 로고    scopus 로고
    • Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C -glycoside
    • Kreuz S. Joubert E. Waldmann K. H. Ternes W. Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C -glycoside. Nutr Res: 2008; 28 690 701
    • (2008) Nutr Res , vol.28 , pp. 690-701
    • Kreuz, S.1    Joubert, E.2    Waldmann, K.H.3    Ternes, W.4
  • 74
    • 84944275874 scopus 로고    scopus 로고
    • Review on the use of cell cultures to study metabolism, transport, and accumulation of flavonoids: From mono-cultures to co-culture systems
    • Gonzales G. B. Van Camp J. Vissenaekens H. Raes K. Smagghe G. Grootaert C. Review on the use of cell cultures to study metabolism, transport, and accumulation of flavonoids: from mono-cultures to co-culture systems. Compr Rev Food Sci Food Saf: 2015; 14 741 754
    • (2015) Compr Rev Food Sci Food Saf , vol.14 , pp. 741-754
    • Gonzales, G.B.1    Van Camp, J.2    Vissenaekens, H.3    Raes, K.4    Smagghe, G.5    Grootaert, C.6
  • 75
    • 79551480499 scopus 로고    scopus 로고
    • Deglycosylation of puerarin and other aromatic C -glucosides by a newly isolated human intestinal bacterium
    • Braune A. Blaut M. Deglycosylation of puerarin and other aromatic C -glucosides by a newly isolated human intestinal bacterium. Environ Microbiol: 2011; 13 482 494
    • (2011) Environ Microbiol , vol.13 , pp. 482-494
    • Braune, A.1    Blaut, M.2
  • 76
    • 24944554453 scopus 로고    scopus 로고
    • Isolation of a human intestinal bacterium that transforms mangiferin to norathyriol and inducibility of the enzyme that cleaves a C -glucosyl bond
    • Sanugul K. Akao T. Li Y. Kakiuchi N. Nakamura N. Hattori M. Isolation of a human intestinal bacterium that transforms mangiferin to norathyriol and inducibility of the enzyme that cleaves a C -glucosyl bond. Biol Pharm Bull: 2005; 28 1672 1678
    • (2005) Biol Pharm Bull , vol.28 , pp. 1672-1678
    • Sanugul, K.1    Akao, T.2    Li, Y.3    Kakiuchi, N.4    Nakamura, N.5    Hattori, M.6
  • 77
    • 78650849540 scopus 로고    scopus 로고
    • The C -glucosyl bond of puerarin was cleaved hydrolytically by a human intestinal bacterium strain PUE to yield its aglycone daidzein and an intact glucose
    • Nakamura K. Nishihata T. Jin J. S. Ma C. M. Komatsu K. Iwashima M. Hattori M. The C -glucosyl bond of puerarin was cleaved hydrolytically by a human intestinal bacterium strain PUE to yield its aglycone daidzein and an intact glucose. Chem Pharm Bull: 2011; 59 23 27
    • (2011) Chem Pharm Bull , vol.59 , pp. 23-27
    • Nakamura, K.1    Nishihata, T.2    Jin, J.S.3    Ma, C.M.4    Komatsu, K.5    Iwashima, M.6    Hattori, M.7
  • 78
    • 84868613767 scopus 로고    scopus 로고
    • Intestinal bacterium Eubacterium cellulosolvens deglycosylates flavonoid C - And O -glucosides
    • Braune A. Blaut M. Intestinal bacterium Eubacterium cellulosolvens deglycosylates flavonoid C - and O -glucosides. Appl Environ Microbiol: 2012; 78 8151 8153
    • (2012) Appl Environ Microbiol , vol.78 , pp. 8151-8153
    • Braune, A.1    Blaut, M.2
  • 79
    • 85048920417 scopus 로고    scopus 로고
    • World health statistics 2012. World Health Organization Accessed September 25, 2017
    • World Health Organization World health statistics 2012. World Health Organization. Available at. http://apps.who.int/iris/bitstream/10665/44844/1/9789241564441-eng.pdf?ua=1 Accessed September 25, 2017
  • 80
    • 0842277242 scopus 로고    scopus 로고
    • Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition
    • Grundy S. M. Brewer H. B. Cleeman J. I. Smith S. C. Lenfant C. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation: 2004; 109 433 438
    • (2004) Circulation , vol.109 , pp. 433-438
    • Grundy, S.M.1    Brewer, H.B.2    Cleeman, J.I.3    Smith, S.C.4    Lenfant, C.5
  • 81
    • 85021855537 scopus 로고    scopus 로고
    • Health effects of overweight and obesity in 195 countries over 25 years
    • GBD 2015 Obesity Collaborators Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med: 2017; 377 13 27
    • (2017) N Engl J Med , vol.377 , pp. 13-27
  • 82
    • 85048903819 scopus 로고    scopus 로고
    • IDF diabetes atlas, 7th Edition. International Diabetes Federation Accessed September 25, 2017
    • International Diabetes Federation IDF diabetes atlas, 7th Edition. International Diabetes Federation. Available at. https://www.idf.org/e-library/epidemiology-research/diabetes-atlas/13-diabetes-atlas-seventh-edition.html Accessed September 25, 2017
  • 83
    • 84884193035 scopus 로고    scopus 로고
    • Beta cell dysfunction and insulin resistance
    • Cerf M. E. Beta cell dysfunction and insulin resistance. Front Endocrinol: 2013; 4 37
    • (2013) Front Endocrinol , vol.4 , pp. 37
    • Cerf, M.E.1
  • 84
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: A metabolic pathway to chronic liver disease
    • Bugianesi E. McCullough A. J. Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology: 2005; 42 987 1000
    • (2005) Hepatology , vol.42 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 85
    • 77955362775 scopus 로고    scopus 로고
    • Chronic inflammation in obesity and the metabolic syndrome
    • Monteiro R. Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm: 2010; 2010 289645
    • (2010) Mediators Inflamm , vol.2010 , pp. 289645
    • Monteiro, R.1    Azevedo, I.2
  • 86
    • 4544249734 scopus 로고    scopus 로고
    • Metabolic syndrome: Dietary interventions
    • Aude Y. W. Mego P. Mehta J. L. Metabolic syndrome: dietary interventions. Curr Opin Cardiol: 2004; 19 473 479
    • (2004) Curr Opin Cardiol , vol.19 , pp. 473-479
    • Aude, Y.W.1    Mego, P.2    Mehta, J.L.3
  • 91
    • 85014050634 scopus 로고    scopus 로고
    • The transcription profile unveils the cardioprotective effect of aspalathin against lipid toxicity in an in vitro H9c2 model
    • Johnson R. Dludla P. Muller C. Huisamen B. Essop M. Louw J. The transcription profile unveils the cardioprotective effect of aspalathin against lipid toxicity in an in vitro H9c2 model. Molecules: 2017; 22 E219
    • (2017) Molecules , vol.22 , pp. E219
    • Johnson, R.1    Dludla, P.2    Muller, C.3    Huisamen, B.4    Essop, M.5    Louw, J.6
  • 92
    • 84941710120 scopus 로고    scopus 로고
    • Aspalathin improves glucose and lipid metabolism in 3T3-L1 adipocytes exposed to palmitate
    • Mazibuko S. E. Joubert E. Johnson R. Louw J. Opoku A. R. Muller C. JF. Aspalathin improves glucose and lipid metabolism in 3T3-L1 adipocytes exposed to palmitate. Mol Nutr Food Res: 2015; 59 2199 2208
    • (2015) Mol Nutr Food Res , vol.59 , pp. 2199-2208
    • Mazibuko, S.E.1    Joubert, E.2    Johnson, R.3    Louw, J.4    Opoku, A.R.5    Muller, C.J.6
  • 94
    • 84879435168 scopus 로고    scopus 로고
    • Metabolic syndrome and insulin resistance: Underlying causes and modification by exercise training
    • Roberts C. K. Hevener A. L. Barnard R. J. Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Compr Physiol: 2013; 3 1 58
    • (2013) Compr Physiol , vol.3 , pp. 1-58
    • Roberts, C.K.1    Hevener, A.L.2    Barnard, R.J.3
  • 96
    • 12944250922 scopus 로고    scopus 로고
    • Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
    • Fang X. Yu S. X. Lu Y. Bast R. C. Woodgett J. R. Mills G. B. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A: 2000; 97 11960 11965
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 11960-11965
    • Fang, X.1    Yu, S.X.2    Lu, Y.3    Bast, R.C.4    Woodgett, J.R.5    Mills, G.B.6
  • 97
    • 0035914388 scopus 로고    scopus 로고
    • Akt1/PKB α is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
    • Cho H. Thorvaldsen J. L. Chu Q. Feng F. Birnbaum M. J. Akt1/PKB α is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem: 2001; 276 38349 38352
    • (2001) J Biol Chem , vol.276 , pp. 38349-38352
    • Cho, H.1    Thorvaldsen, J.L.2    Chu, Q.3    Feng, F.4    Birnbaum, M.J.5
  • 99
    • 33947596679 scopus 로고    scopus 로고
    • The GLUT4 glucose transporter
    • Huang S. Czech M. P. The GLUT4 glucose transporter. Cell Metab: 2007; 5 237 252
    • (2007) Cell Metab , vol.5 , pp. 237-252
    • Huang, S.1    Czech, M.P.2
  • 100
    • 84874993428 scopus 로고    scopus 로고
    • AMPK and exercise: Glucose uptake and insulin sensitivity
    • ONeill H. M. AMPK and exercise: glucose uptake and insulin sensitivity. Diabetes Metab J: 2013; 37 1 21
    • (2013) Diabetes Metab J , vol.37 , pp. 1-21
    • Oneill, H.M.1
  • 101
    • 84978708804 scopus 로고    scopus 로고
    • AMPK activators: Mechanisms of action and physiological activities
    • Kim J. Yang G. Kim Y. Kim J. Ha J. AMPK activators: mechanisms of action and physiological activities. Exp Mol Med: 2016; 48 e224
    • (2016) Exp Mol Med , vol.48 , pp. e224
    • Kim, J.1    Yang, G.2    Kim, Y.3    Kim, J.4    Ha, J.5
  • 102
    • 84962693099 scopus 로고    scopus 로고
    • Aspalathin, a dihydrochalcone C -glucoside, protects H9c2 cardiomyocytes against high glucose induced shifts in substrate preference and apoptosis
    • Johnson R. Dludla P. Joubert E. February F. Mazibuko S. Ghoor S. Muller C. Louw J. Aspalathin, a dihydrochalcone C -glucoside, protects H9c2 cardiomyocytes against high glucose induced shifts in substrate preference and apoptosis. Mol Nutr Food Res: 2016; 60 922 934
    • (2016) Mol Nutr Food Res , vol.60 , pp. 922-934
    • Johnson, R.1    Dludla, P.2    Joubert, E.3    February, F.4    Mazibuko, S.5    Ghoor, S.6    Muller, C.7    Louw, J.8
  • 104
    • 33745204925 scopus 로고    scopus 로고
    • AMPK alterations in cardiac physiology and pathology: Enemy or ally?
    • Dyck J. RB. Lopaschuk G. D. AMPK alterations in cardiac physiology and pathology: enemy or ally? J Physiol: 2006; 574 95 112
    • (2006) J Physiol , vol.574 , pp. 95-112
    • Dyck, J.R.1    Lopaschuk, G.D.2
  • 105
    • 66349099340 scopus 로고    scopus 로고
    • Fatty acid metabolism: Target for metabolic syndrome
    • Wakil S. J. Abu-Elheiga L. A. Fatty acid metabolism: target for metabolic syndrome. J Lipid Res: 2009; 50 S138 S143
    • (2009) J Lipid Res , vol.50 , pp. S138-S143
    • Wakil, S.J.1    Abu-Elheiga, L.A.2
  • 106
    • 34250616386 scopus 로고    scopus 로고
    • Fatty acid metabolism in adipose tissue, muscle and liver in health and disease
    • Frayn K. N. Arner P. Yki-Jarvinen H. Fatty acid metabolism in adipose tissue, muscle and liver in health and disease. Essays Biochem: 2006; 42 89 103
    • (2006) Essays Biochem , vol.42 , pp. 89-103
    • Frayn, K.N.1    Arner, P.2    Yki-Jarvinen, H.3
  • 108
    • 56249108377 scopus 로고    scopus 로고
    • Intracellular lipid accumulation in liver and muscle and the insulin resistance syndrome
    • Lara-Castro C. Garvey W. T. Intracellular lipid accumulation in liver and muscle and the insulin resistance syndrome. Endocrinol Metab Clin North Am: 2008; 37 841 856
    • (2008) Endocrinol Metab Clin North Am , vol.37 , pp. 841-856
    • Lara-Castro, C.1    Garvey, W.T.2
  • 109
    • 84893060758 scopus 로고    scopus 로고
    • Fatty acid metabolism, energy expenditure and insulin resistance in muscle
    • Turner N. Cooney G. J. Kraegen E. W. Bruce C. R. Fatty acid metabolism, energy expenditure and insulin resistance in muscle. J Endocrinol: 2014; 220 T61 T79
    • (2014) J Endocrinol , vol.220 , pp. T61-T79
    • Turner, N.1    Cooney, G.J.2    Kraegen, E.W.3    Bruce, C.R.4
  • 110
    • 78349297565 scopus 로고    scopus 로고
    • Oxidative stress and diabetic complications
    • Giacco F. Brownlee M. Oxidative stress and diabetic complications. Circ Res: 2010; 107 1058 1070
    • (2010) Circ Res , vol.107 , pp. 1058-1070
    • Giacco, F.1    Brownlee, M.2
  • 111
    • 65049089113 scopus 로고    scopus 로고
    • Regulation of glutathione synthesis
    • Lu S. C. Regulation of glutathione synthesis. Mol Aspects Med: 2009; 30 42 59
    • (2009) Mol Aspects Med , vol.30 , pp. 42-59
    • Lu, S.C.1
  • 112
    • 57849121240 scopus 로고    scopus 로고
    • Free radicals, antioxidants in disease and health
    • Pham-Huy L. He H. Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci: 2008; 4 89 96
    • (2008) Int J Biomed Sci , vol.4 , pp. 89-96
    • Pham-Huy, L.1    He, H.2    Pham-Huy, C.3
  • 113
    • 23244451614 scopus 로고    scopus 로고
    • The role of oxidative stress in diabetic complications
    • Niedowicz D. M. Daleke D. L. The role of oxidative stress in diabetic complications. Cell Biochem Biophys: 2005; 43 289 330
    • (2005) Cell Biochem Biophys , vol.43 , pp. 289-330
    • Niedowicz, D.M.1    Daleke, D.L.2
  • 114
    • 84959018825 scopus 로고    scopus 로고
    • Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies
    • Rani V. Deep G. Singh R. K. Palle K. Yadav U. CS. Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. Life Sci: 2016; 148 183 193
    • (2016) Life Sci , vol.148 , pp. 183-193
    • Rani, V.1    Deep, G.2    Singh, R.K.3    Palle, K.4    Yadav, U.C.5
  • 116
    • 11244318176 scopus 로고    scopus 로고
    • Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels
    • Yesilbursa D. Serdar Z. Serdar A. Sarac M. Coskun S. Jale C. Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels. Int J Obes: 2005; 29 142 145
    • (2005) Int J Obes , vol.29 , pp. 142-145
    • Yesilbursa, D.1    Serdar, Z.2    Serdar, A.3    Sarac, M.4    Coskun, S.5    Jale, C.6
  • 117
    • 85048915797 scopus 로고    scopus 로고
    • The role of malondialdehyde and glutathione in metabolic syndromes complications
    • Avci E. Avci G. A. Cevher S. C. The role of malondialdehyde and glutathione in metabolic syndromes complications. J Biotechnol: 2017; 256 S32
    • (2017) J Biotechnol , vol.256 , pp. S32
    • Avci, E.1    Avci, G.A.2    Cevher, S.C.3
  • 119
    • 84907999343 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein and total antioxidant capacity in type-2 diabetic and impaired glucose tolerance Saudi men
    • Nour Eldin E. E. Almarzouki A. Assiri A. Elsheikh O. Mohamed B. E. Babakr A. Oxidized low density lipoprotein and total antioxidant capacity in type-2 diabetic and impaired glucose tolerance Saudi men. Diabetol Metab Syndr: 2014; 6 94
    • (2014) Diabetol Metab Syndr , vol.6 , pp. 94
    • Nour Eldin, E.E.1    Almarzouki, A.2    Assiri, A.3    Elsheikh, O.4    Mohamed, B.E.5    Babakr, A.6
  • 120
    • 84884193931 scopus 로고    scopus 로고
    • Mechanisms of obesity-induced inflammation and insulin resistance: Insights into the emerging role of nutritional strategies
    • McArdle M. A. Finucane O. M. Connaughton R. M. McMorrow A. M. Roche H. M. Mechanisms of obesity-induced inflammation and insulin resistance: Insights into the emerging role of nutritional strategies. Front Endocrinol: 2013; 4 52
    • (2013) Front Endocrinol , vol.4 , pp. 52
    • McArdle, M.A.1    Finucane, O.M.2    Connaughton, R.M.3    McMorrow, A.M.4    Roche, H.M.5
  • 121
    • 84872271216 scopus 로고    scopus 로고
    • Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: A need for screening tools to target interventions
    • DeBoer M. D. Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: a need for screening tools to target interventions. Nutrition: 2013; 29 379 386
    • (2013) Nutrition , vol.29 , pp. 379-386
    • Deboer, M.D.1
  • 122
    • 84928243640 scopus 로고    scopus 로고
    • Impaired adipose tissue expandability and lipogenic capacities as ones of the main causes of metabolic disorders
    • Moreno-Indias I. Tinahones F. J. Impaired adipose tissue expandability and lipogenic capacities as ones of the main causes of metabolic disorders. J Diabetes Res: 2015; 2015 970375
    • (2015) J Diabetes Res , vol.2015 , pp. 970375
    • Moreno-Indias, I.1    Tinahones, F.J.2
  • 123
    • 84898638844 scopus 로고    scopus 로고
    • Obesity and its metabolic complications: The role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease
    • Jung U. Choi M. S. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci: 2014; 15 6184 6223
    • (2014) Int J Mol Sci , vol.15 , pp. 6184-6223
    • Jung, U.1    Choi, M.S.2
  • 124
    • 84880974817 scopus 로고    scopus 로고
    • Adipokines mediate inflammation and insulin resistance
    • Kwon H. Pessin J. E. Adipokines mediate inflammation and insulin resistance. Front Endocrinol: 2013; 4 71
    • (2013) Front Endocrinol , vol.4 , pp. 71
    • Kwon, H.1    Pessin, J.E.2
  • 125
    • 44849116310 scopus 로고    scopus 로고
    • The perfect storm: Obesity, adipocyte dysfunction, and metabolic consequences
    • De Ferranti S. Mozaffarian D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem: 2008; 54 945 955
    • (2008) Clin Chem , vol.54 , pp. 945-955
    • De Ferranti, S.1    Mozaffarian, D.2
  • 126
    • 85042858042 scopus 로고    scopus 로고
    • Adiponectin and its hydrolase-activated receptors
    • Sharma A. Holland W. Adiponectin and its hydrolase-activated receptors. J Nat Sci: 2017; 3 e396
    • (2017) J Nat Sci , vol.3 , pp. e396
    • Sharma, A.1    Holland, W.2
  • 127
    • 84982740442 scopus 로고    scopus 로고
    • Adiponectin, TNF- α and inflammatory cytokines and risk of type 2 diabetes: A systematic review and meta-analysis
    • Liu C. Feng X. Li Q. Wang Y. Li Q. Hua M. Adiponectin, TNF- α and inflammatory cytokines and risk of type 2 diabetes: A systematic review and meta-analysis. Cytokine: 2016; 86 100 109
    • (2016) Cytokine , vol.86 , pp. 100-109
    • Liu, C.1    Feng, X.2    Li, Q.3    Wang, Y.4    Li, Q.5    Hua, M.6
  • 128
    • 34147126829 scopus 로고    scopus 로고
    • The role of TNF- α in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk
    • Popa C. Netea M. G. van Riel P. L. van der Meer J. WM. Stalenhoef A. FH. The role of TNF- α in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res: 2007; 48 751 762
    • (2007) J Lipid Res , vol.48 , pp. 751-762
    • Popa, C.1    Netea, M.G.2    Van Riel, P.L.3    Van Dar Meer, J.W.4    Stalenhoef, A.F.5
  • 129
    • 84908306827 scopus 로고    scopus 로고
    • Role of adiponectin in metabolic and cardiovascular disease
    • Lee S. Kwak H. B. Role of adiponectin in metabolic and cardiovascular disease. J Exerc Rehabil: 2014; 10 54 59
    • (2014) J Exerc Rehabil , vol.10 , pp. 54-59
    • Lee, S.1    Kwak, H.B.2
  • 131
    • 77949442621 scopus 로고    scopus 로고
    • Kollias G. Sfikakis P. edis TNF Pathophysiology. Molecular and cellular Mechanisms Basel, Switzerland Karger
    • Tzanavari T. Giannogonas P. Karalis K. P. TNF- α and Obesity. In: Kollias G. Sfikakis P. edis TNF Pathophysiology. Molecular and cellular Mechanisms. Basel, Switzerland Karger: 2010; 145 156
    • (2010) TNF- α and Obesity , pp. 145-156
    • Tzanavari, T.1    Giannogonas, P.2    Karalis, K.P.3
  • 133
    • 84900872494 scopus 로고    scopus 로고
    • Adipose tissue in obesity-related inflammation and insulin resistance: Cells, cytokines, and chemokines
    • Makki K. Froguel P. Wolowczuk I. Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. ISRN Inflamm: 2013; 2013 139239
    • (2013) ISRN Inflamm , vol.2013 , pp. 139239
    • Makki, K.1    Froguel, P.2    Wolowczuk, I.3
  • 134
    • 84957812743 scopus 로고    scopus 로고
    • The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
    • Buzzetti E. Pinzani M. Tsochatzis E. A. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism: 2016; 65 1038 1048
    • (2016) Metabolism , vol.65 , pp. 1038-1048
    • Buzzetti, E.1    Pinzani, M.2    Tsochatzis, E.A.3
  • 135
    • 0036079637 scopus 로고    scopus 로고
    • Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity
    • Diraison F. Dusserre E. Vidal H. Sothier M. Beylot M. Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity. Am J Physiol Endocrinol Metab: 2002; 282 E46 E51
    • (2002) Am J Physiol Endocrinol Metab , vol.282 , pp. E46-E51
    • Diraison, F.1    Dusserre, E.2    Vidal, H.3    Sothier, M.4    Beylot, M.5
  • 137
    • 0032494169 scopus 로고    scopus 로고
    • Endothelial cell E- and P-selectin and vascular cell adhesion molecule-1 function as signaling receptors
    • Lorenzon P. Vecile E. Nardon E. Ferrero E. Harlan J. M. Tedesco F. Dobrina A. Endothelial cell E- and P-selectin and vascular cell adhesion molecule-1 function as signaling receptors. J Cell Biol: 1998; 142 1381 1391
    • (1998) J Cell Biol , vol.142 , pp. 1381-1391
    • Lorenzon, P.1    Vecile, E.2    Nardon, E.3    Ferrero, E.4    Harlan, J.M.5    Tedesco, F.6    Dobrina, A.7
  • 138
    • 84963594659 scopus 로고    scopus 로고
    • Effects of dietary polyphenols on metabolic syndrome features in humans: A systematic review
    • Amiot M. J. Riva C. Vinet A. Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review. Obes Rev: 2016; 17 573 586
    • (2016) Obes Rev , vol.17 , pp. 573-586
    • Amiot, M.J.1    Riva, C.2    Vinet, A.3
  • 139
    • 64449086955 scopus 로고    scopus 로고
    • Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice
    • Kawano A. Nakamura H. Hata S. Minakawa M. Miura Y. Yagasaki K. Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice. Phytomedicine: 2009; 16 437 443
    • (2009) Phytomedicine , vol.16 , pp. 437-443
    • Kawano, A.1    Nakamura, H.2    Hata, S.3    Minakawa, M.4    Miura, Y.5    Yagasaki, K.6
  • 140
    • 84870428902 scopus 로고    scopus 로고
    • Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential
    • Muller C. JF. Joubert E. De Beer D. Sanderson M. Malherbe C. J. Fey S. J. Louw J. Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential. Phytomedicine: 2012; 20 32 39
    • (2012) Phytomedicine , vol.20 , pp. 32-39
    • Muller, C.J.1    Joubert, E.2    De Beer, D.3    Sanderson, M.4    Malherbe, C.J.5    Fey, S.J.6    Louw, J.7
  • 141
    • 84943591652 scopus 로고    scopus 로고
    • Green rooibos extract from Aspalathus linearis, and its component, aspalathin, suppress elevation of blood glucose levels in mice and inhibit α -amylase and α -glucosidase activities in vitro
    • Mikami N. Tsujimura J. Sato A. Narasada A. Shigeta M. Kato M. Hata S. Hitomi E. Green rooibos extract from Aspalathus linearis, and its component, aspalathin, suppress elevation of blood glucose levels in mice and inhibit α -amylase and α -glucosidase activities in vitro. Food Sci Technol Res: 2015; 21 231 240
    • (2015) Food Sci Technol Res , vol.21 , pp. 231-240
    • Mikami, N.1    Tsujimura, J.2    Sato, A.3    Narasada, A.4    Shigeta, M.5    Kato, M.6    Hata, S.7    Hitomi, E.8
  • 142
    • 84879885429 scopus 로고    scopus 로고
    • Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis)
    • Mazibuko S. E. Muller C. JF. Joubert E. De Beer D. Johnson R. Opoku A. R. Louw J. Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis). Phytomedicine: 2013; 20 813 819
    • (2013) Phytomedicine , vol.20 , pp. 813-819
    • Mazibuko, S.E.1    Muller, C.J.2    Joubert, E.3    De Beer, D.4    Johnson, R.5    Opoku, A.R.6    Louw, J.7
  • 143
    • 84891836160 scopus 로고    scopus 로고
    • Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice
    • Son M. J. Minakawa M. Miura Y. Yagasaki K. Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice. Eur J Nutr: 2013; 52 1607 1619
    • (2013) Eur J Nutr , vol.52 , pp. 1607-1619
    • Son, M.J.1    Minakawa, M.2    Miura, Y.3    Yagasaki, K.4
  • 144
    • 85027019631 scopus 로고    scopus 로고
    • Myocardial glucose clearance by aspalathin treatment in young, mature, and obese insulin-resistant rats
    • Smit S. Johnson R. Van Vuuren M. Huisamen B. Myocardial glucose clearance by aspalathin treatment in young, mature, and obese insulin-resistant rats. Planta Med: 2018; 84 75 83
    • (2018) Planta Med , vol.84 , pp. 75-83
    • Smit, S.1    Johnson, R.2    Van Vuuren, M.3    Huisamen, B.4
  • 145
    • 85030766226 scopus 로고    scopus 로고
    • Aspalathin reverts doxorubicin-induced cardiotoxicity through ncreased autophagy and decreased expression of p53/mTOR/p62 Signaling
    • Johnson R. Shabalala S. Louw J. Kappo A. Muller C. Aspalathin reverts doxorubicin-induced cardiotoxicity through ncreased autophagy and decreased expression of p53/mTOR/p62 Signaling. Molecules: 2017; 22 E1589
    • (2017) Molecules , vol.22 , pp. E1589
    • Johnson, R.1    Shabalala, S.2    Louw, J.3    Kappo, A.4    Muller, C.5
  • 146
    • 85022215298 scopus 로고    scopus 로고
    • The effect of aspalathin on levels of sugar and lipids in streptozotocin-induced diabetic and normal rats
    • Najafian M. Najafian B. Najafian Z. The effect of aspalathin on levels of sugar and lipids in streptozotocin-induced diabetic and normal rats. Zahedan J Res Med Sci: 2016; 18 e4963
    • (2016) Zahedan J Res Med Sci , vol.18 , pp. e4963
    • Najafian, M.1    Najafian, B.2    Najafian, Z.3
  • 147
    • 84954348452 scopus 로고    scopus 로고
    • Short-term and sub-chronic dietary exposure to aspalathin-enriched green rooibos (Aspalathus linearis) extract affects rat liver function and antioxidant status
    • Van der Merwe J. De Beer D. Joubert E. Gelderblom W. Short-term and sub-chronic dietary exposure to aspalathin-enriched green rooibos (Aspalathus linearis) extract affects rat liver function and antioxidant status. Molecules: 2015; 20 22674 22690
    • (2015) Molecules , vol.20 , pp. 22674-22690
    • Van Dar Merwe, J.1    De Beer, D.2    Joubert, E.3    Gelderblom, W.4
  • 149
    • 85006713335 scopus 로고    scopus 로고
    • Krill oil supplementation improves dyslipidemia and lowers body weight in mice fed a high-fat diet through activation of AMP-activated protein kinase
    • Yang G. Lee J. Lee S. Kwak D. Choe W. Kang I. Kim S. S. Ha J. Krill oil supplementation improves dyslipidemia and lowers body weight in mice fed a high-fat diet through activation of AMP-activated protein kinase. J Med Food: 2016; 19 1120 1129
    • (2016) J Med Food , vol.19 , pp. 1120-1129
    • Yang, G.1    Lee, J.2    Lee, S.3    Kwak, D.4    Choe, W.5    Kang, I.6    Kim, S.S.7    Ha, J.8
  • 150
    • 84971497663 scopus 로고    scopus 로고
    • Regulation of AMP-activated protein kinase by natural and synthetic activators
    • Hardie D. G. Regulation of AMP-activated protein kinase by natural and synthetic activators. Acta Pharm Sin B: 2016; 6 1 19
    • (2016) Acta Pharm Sin B , vol.6 , pp. 1-19
    • Hardie, D.G.1
  • 151
    • 84979529782 scopus 로고    scopus 로고
    • Erratum: Short-term and sub-chronic dietary exposure to aspalathin-enriched green rooibos (Aspalathus linearis) extract affects rat liver function and antioxidant status
    • Van der Merwe J. D. De Beer D. Joubert E. Gelderblom W. CA. Erratum: Short-term and sub-chronic dietary exposure to aspalathin-enriched green rooibos (Aspalathus linearis) extract affects rat liver function and antioxidant status. Molecules: 2016; 21 E907
    • (2016) Molecules , vol.21 , pp. E907
    • Van Dar Merwe, J.D.1    De Beer, D.2    Joubert, E.3    Gelderblom, W.C.4
  • 152
    • 84873729069 scopus 로고    scopus 로고
    • Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans
    • Chen W. Sudji I. R. Wang E. Joubert E. Van Wyk B. E. Wink M. Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans. Phytomedicine: 2013; 20 380 386
    • (2013) Phytomedicine , vol.20 , pp. 380-386
    • Chen, W.1    Sudji, I.R.2    Wang, E.3    Joubert, E.4    Van Wyk, B.E.5    Wink, M.6
  • 153
    • 84890230260 scopus 로고    scopus 로고
    • Xanthine oxidase inhibitory activity and hypouricemic effect of aspalathin from unfermented rooibos
    • Kondo M. Hirano Y. Nishio M. Furuya Y. Nakamura H. Watanabe T. Xanthine oxidase inhibitory activity and hypouricemic effect of aspalathin from unfermented rooibos. J Food Sci: 2013; 78 H1935 H1939
    • (2013) J Food Sci , vol.78 , pp. H1935-H1939
    • Kondo, M.1    Hirano, Y.2    Nishio, M.3    Furuya, Y.4    Nakamura, H.5    Watanabe, T.6
  • 154
    • 85048911924 scopus 로고    scopus 로고
    • Green rooibos extract improves plasma lipid profile and oxidative status in diabetic non-human primates
    • Orlando P. Chellan N. Muller C. Louw J. Chapman C. Joubert E. Tiano L. Green rooibos extract improves plasma lipid profile and oxidative status in diabetic non-human primates. Free Radic Biol Med: 2017; 108 S96 S97
    • (2017) Free Radic Biol Med , vol.108 , pp. S96-S97
    • Orlando, P.1    Chellan, N.2    Muller, C.3    Louw, J.4    Chapman, C.5    Joubert, E.6    Tiano, L.7
  • 155
    • 78650679662 scopus 로고    scopus 로고
    • Effects of rooibos (Aspalathus linearis) on oxidative stress and biochemical parameters in adults at risk for cardiovascular disease
    • Marnewick J. L. Rautenbach F. Venter I. Neethling H. Blackhurst D. M. Wolmarans P. Macharia M. Effects of rooibos (Aspalathus linearis) on oxidative stress and biochemical parameters in adults at risk for cardiovascular disease. J Ethnopharmacol: 2011; 133 46 52
    • (2011) J Ethnopharmacol , vol.133 , pp. 46-52
    • Marnewick, J.L.1    Rautenbach, F.2    Venter, I.3    Neethling, H.4    Blackhurst, D.M.5    Wolmarans, P.6    Macharia, M.7
  • 156
    • 84930868252 scopus 로고    scopus 로고
    • Antithrombotic activities of aspalathin and nothofagin via inhibiting platelet aggregation and FIIa/FXa
    • Ku S. K. Lee W. Kang M. Bae J. S. Antithrombotic activities of aspalathin and nothofagin via inhibiting platelet aggregation and FIIa/FXa. Arch Pharm Res: 2015; 38 1080 1089
    • (2015) Arch Pharm Res , vol.38 , pp. 1080-1089
    • Ku, S.K.1    Lee, W.2    Kang, M.3    Bae, J.S.4
  • 157
    • 84925489663 scopus 로고    scopus 로고
    • Aspalathin and nothofagin from rooibos (Aspalathus linearis) inhibits high glucose-induced inflammation in vitro and in vivo
    • Ku S. K. Kwak S. Kim Y. Bae J. S. Aspalathin and nothofagin from rooibos (Aspalathus linearis) inhibits high glucose-induced inflammation in vitro and in vivo. Inflammation: 2015; 38 445 455
    • (2015) Inflammation , vol.38 , pp. 445-455
    • Ku, S.K.1    Kwak, S.2    Kim, Y.3    Bae, J.S.4
  • 158
    • 84940377464 scopus 로고    scopus 로고
    • Ameliorative effect of aspalathin and nothofagin from rooibos (Aspalathus linearis) on HMGB1-induced septic responses in vitro and in vivo
    • Lee W. Kim K. M. Bae J. S. Ameliorative effect of aspalathin and nothofagin from rooibos (Aspalathus linearis) on HMGB1-induced septic responses in vitro and in vivo. Am J Chin Med: 2015; 43 991 1012
    • (2015) Am J Chin Med , vol.43 , pp. 991-1012
    • Lee, W.1    Kim, K.M.2    Bae, J.S.3
  • 159
    • 0031973176 scopus 로고    scopus 로고
    • Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvement of different pathological processes
    • Kurosawa S. Stearns-Kurosawa D. Carson C. DAngelo A. Della Valle P. Esmon C. Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes. Blood: 1998; 91 725 728
    • (1998) Blood , vol.91 , pp. 725-728
    • Kurosawa, S.1    Stearns-Kurosawa, D.2    Carson, C.3    Dangelo, A.4    Della Valle, P.5    Esmon, C.6
  • 161
    • 84898057712 scopus 로고    scopus 로고
    • The cardioprotective effect of an aqueous extract of fermented rooibos (Aspalathus linearis) on cultured cardiomyocytes derived from diabetic rats
    • Dludla P. V. Muller C. JF. Louw J. Joubert E. Salie R. Opoku A. R. Johnson R. The cardioprotective effect of an aqueous extract of fermented rooibos (Aspalathus linearis) on cultured cardiomyocytes derived from diabetic rats. Phytomedicine: 2014; 21 595 601
    • (2014) Phytomedicine , vol.21 , pp. 595-601
    • Dludla, P.V.1    Muller, C.J.2    Louw, J.3    Joubert, E.4    Salie, R.5    Opoku, A.R.6    Johnson, R.7
  • 162
    • 84937252261 scopus 로고    scopus 로고
    • Anti-inflammatory effects of aspalathin and nothofagin from rooibos (Aspalathus linearis) in vitro and in vivo
    • Lee W. Bae J. S. Anti-inflammatory effects of aspalathin and nothofagin from rooibos (Aspalathus linearis) in vitro and in vivo. Inflammation: 2015; 38 1502 1516
    • (2015) Inflammation , vol.38 , pp. 1502-1516
    • Lee, W.1    Bae, J.S.2
  • 163
    • 84920475662 scopus 로고    scopus 로고
    • Aspalathin and nothofagin from rooibos (Aspalathus linearis) inhibit endothelial protein C receptor shedding in vitro and in vivo
    • Kwak S. Han M. S. Bae J. S. Aspalathin and nothofagin from rooibos (Aspalathus linearis) inhibit endothelial protein C receptor shedding in vitro and in vivo. Fitoterapia: 2015; 100 179 186
    • (2015) Fitoterapia , vol.100 , pp. 179-186
    • Kwak, S.1    Han, M.S.2    Bae, J.S.3
  • 164
    • 0034620261 scopus 로고    scopus 로고
    • Herb-drug interactions
    • Fugh-Berman A. Herb-drug interactions. Lancet: 2000; 355 134 138
    • (2000) Lancet , vol.355 , pp. 134-138
    • Fugh-Berman, A.1
  • 165
  • 166
    • 84926681081 scopus 로고    scopus 로고
    • Tea not tincture: Hepatotoxicity associated with rooibos herbal tea
    • Engels M. Wang C. Matoso A. Maidan E. Wands J. Tea not tincture: hepatotoxicity associated with rooibos herbal tea. ACG Case Reports J: 2013; 1 58 60
    • (2013) ACG Case Reports J , vol.1 , pp. 58-60
    • Engels, M.1    Wang, C.2    Matoso, A.3    Maidan, E.4    Wands, J.5
  • 167
    • 85048919630 scopus 로고    scopus 로고
    • Rooibos herbal tea linked to hepatotoxicity and severe hypercholesterolemia
    • Zacharia C. C. Whitlatch H. Rooibos herbal tea linked to hepatotoxicity and severe hypercholesterolemia. Endocrinol Rev: 2013; 34 SUN-730
    • (2013) Endocrinol Rev , vol.34 , pp. SUN-730
    • Zacharia, C.C.1    Whitlatch, H.2
  • 168
    • 84997497931 scopus 로고    scopus 로고
    • Inhibitory interactions of Aspalathus linearis (rooibos) extracts and compounds, aspalathin and Z -2-(β -D-glucopyranosyloxy)-3-phenylpropenoic acid, on cytochromes metabolizing hypoglycemic and hypolipidemic drugs
    • Patel O. Muller C. Joubert E. Louw J. Rosenkranz B. Awortwe C. Inhibitory interactions of Aspalathus linearis (rooibos) extracts and compounds, aspalathin and Z -2-(β -D-glucopyranosyloxy)-3-phenylpropenoic acid, on cytochromes metabolizing hypoglycemic and hypolipidemic drugs. Molecules: 2016; 21 E1515
    • (2016) Molecules , vol.21 , pp. E1515
    • Patel, O.1    Muller, C.2    Joubert, E.3    Louw, J.4    Rosenkranz, B.5    Awortwe, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.