Metabolic engineering of Saccharomyces cerevisiae for de novo production of dihydrochalcones with known antioxidant, antidiabetic, and sweet tasting properties

Metabolic Engineering

Volumn 39, Issue , 2017, Pages 80-89

  Eichenberger, Michael ^a,b   Lehka, Beata Joanna ^c,d   Folly, Christophe ^a   Fischer, David ^a   Martens, Stefan ^e   Simón, Ernesto ^a   Naesby, Michael ^a  

^a EVOLVA SA   (Switzerland)

^b DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^c Evolva Biotech A S   (Denmark)

^d ROSKILDE UNIVERSITY   (Denmark)

^e RESEARCH AND INNOVATION CENTRE   (Italy)

Author keywords

Dihydrochalcone; Double bond reductase; Naringin dihydrochalcone; Nothofagin; Phlorizin; Saccharomyces cerevisiae

Indexed keywords

ANTIOXIDANTS; BIOCHEMISTRY; BIOSYNTHESIS; BYPRODUCTS; ENZYMES; FLAVONOIDS; METABOLIC ENGINEERING; METABOLITES; MOLECULES; SUBSTRATES;

ANTIOXIDANT MOLECULES; DE NOVO PRODUCTION; DIHYDROCHALCONE; DOUBLE BONDS; NOTHOFAGIN; PHLORIZIN; PLANT SECONDARY METABOLITES; SUBSTRATE SPECIFICITY;

YEAST;

2,4 DIENOYL COENZYME A REDUCTASE (NADPH); 3 HYDROXYPHLORETIN; ANTIDIABETIC AGENT; ANTIOXIDANT; AURANTIIN; CHALCONE DERIVATIVE; CHALCONE SYNTHASE; CINNAMIC ACID; COENZYME A; CYTOCHROME P450 REDUCTASE; DIHYDROCHALCONE DERIVATIVE; NARINGENIN; NARINGIN DIHYDROCHALCONE; NOTHOFAGIN; PARA COUMARIC ACID; PARA COUMAROYL COENZYME A; PARA DIHYDROCOUMAROYL COENZYME A; PHLORETIN; PHLORIZIN; PINOCEMBRINE; POLYPHENOL DERIVATIVE; SWEETENING AGENT; UNCLASSIFIED DRUG; DIHYDROCHALCONE; SACCHAROMYCES CEREVISIAE PROTEIN;

ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BARLEY; BIOSYNTHESIS; CONTROLLED STUDY; DRUG SCREENING; DRUG SPECIFICITY; DRUG SYNTHESIS; GENE OVEREXPRESSION; HETEROLOGOUS EXPRESSION; METABOLIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SWEETNESS; GENETIC ENHANCEMENT; METABOLISM; PHYSIOLOGY; PROCEDURES;

ANTIOXIDANTS; BIOSYNTHETIC PATHWAYS; CHALCONES; GENETIC ENHANCEMENT; HYPOGLYCEMIC AGENTS; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SWEETENING AGENTS;

EID: 85009935517     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.10.019     Document Type: Article

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