Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity

American Journal of Physiology - Endocrinology and Metabolism

Volumn 282, Issue 1 45-1, 2002, Pages

  Diraison, Frédérique ^a   Dusserre, Eric ^a   Vidal, Hubert ^a   Sothier, Monique ^b   Beylot, Michel ^a  

^a INSERM   (France)

^b EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

Fatty acid synthase; Lipids; Messenger ribonucleic acid; Stable isotope; Sterol regulatory element binding protein 1c

Indexed keywords

CHOLESTEROL; FATTY ACID SYNTHASE; INSULIN; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ADIPOSE TISSUE; ADULT; ARTICLE; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY RESOURCE; FEMALE; GENE EXPRESSION; HUMAN; INSULIN BLOOD LEVEL; LIPID STORAGE; LIPOGENESIS; LIVER METABOLISM; MALE; OBESITY; PRIORITY JOURNAL; PROTEIN DETERMINATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT;

EID: 0036079637     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2002.282.1.e46     Document Type: Article

References (44)

1. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man
2. The use of reverse transcription competitive polymerase chain reaction to investigate the in vivo regulation of gene expression in small tissue samples
3. Obese gene expression alters the ability of 30A5 prreadipocytes to respond to lipogenic hormones
4. Influence of human obesity on the metabolic fate of dietary long and medium-chain triacylglycerols
5. Carbohydrate storage in man: Speculations and some quantitative considerations
6. Genetics of human obesity: Research direction
7. Leptin has acute effects on glucose and lipid metabolism in both lean and gold thioglucose-obese mice
8. Insulin increases fatty acid synthase gene transcription in human adipocytes
9. Role of human liver lipogenesis and reesterification in triglycerides in triglycerides secretion and in FFA reesterification
10. In vivo determination of plasma cholesterol and fatty acids synthesis with deuterated water: Determination of the average number of deuterium incorporated
11. Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: Use of simple gas chromatography mass spectrometry techniques
12. Cytokines induce catabolic effects in cultured adipocytes by multiple mechanism
13. Quantification of menstrual and diurnal periodocities in rates of cholesterol and fat synthesis in humans
14. Regulation of gene expression by glucose
15. A simple method for the isolation and purification of total lipids from animal tissues
16. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
17. ADD1/SREBP- 1c is required in the activation of hepatic lipogenic gene expression by glucose
18. Glucose stimulation of lipogenic enzyme gene expression in cultured white adipose tissue
19. Regulation of lipogenic enzyme gene expression by nutrients and hormones
20. Genetic regulation of fatty acid synthetase expression in adipose tissue: Overtranscription of the gene in genetically obese rats
21. Regulation of cholesterol biosynthesis by diet in humans
22. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
23. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss and relationship to lipoprotein lipase
24. Synthesis and antitumor activity of an inhibitor of fatty acid synthase
25. Hormone-sensitive lipase expression and activity in relation to lipolysis in human fat cells
26. Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function
27. Decreased expression and function of adipocyte hormone-sensitive lipase in sub-cutaneous fat cells of obese subjects
28. Loss of regulation of lipogenesis in the Zucher diabetic (ZDF) rat
29. Depot-specific differences in adipose tissue gene expression in lean and obese subjects
30. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
31. Different sterol regulatory element binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase
32. Uptake of glucose carbon in muscle glycogen and adipose tissue triglycerides in vivo in humans
33. Glucose uptake in human adipose tissue
34. Arachidonic acid inhibits lipogenic gene expression in 3T3-L 1 adipocytes through a prostanoid pathway
35. Arachidonic acid and PGE 2 regulation of hepatic lipogenic gene expression
36. Sterol response element binding protein 1c is involved in the polyunsaturated fatty acid suppression of hepatic S14 gene transcription
37. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol
38. Insulin increases lipogenic enzyme activity in human adipocytes in primary cultures
39. The expression of adipogenic genes is decreased in obesity and diabetes mellitus
40. Leptin specific patterns of gene expression in white adipose tissue
41. Comparative study of the lipogenic potential of human and rat adipose tissue
42. Relative expansion of extracellular fluid in obese vs nonobese women
43. Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y and Sp1-binding sites
44. Assay of low deuterium enrichment of water by isotopic exchange with [U-13C]acetone and gas chromatography mass spectrometry