Effects of dietary polyphenols on metabolic syndrome features in humans: A systematic review

Obesity Reviews

Volumn 17, Issue 7, 2016, Pages 573-586

  Amiot, M J ^a,b,c   Riva, C ^d   Vinet, A ^d  

^a CEMAGREF   (France)

^b INSERM   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d UNIVERSITY OF AVIGNON   (France)

Author keywords

Blood pressure; Dyslipidemia; Insulin resistance; Weight management

Indexed keywords

ANTHOCYANIN; GLUCOSE; HESPERIDIN; ISOFLAVONE DERIVATIVE; LIPID; POLYPHENOL; QUERCETIN; RESVERATROL; ANTIOXIDANT; GLUCOSE BLOOD LEVEL; INSULIN;

ARTICLE; BERRY; BLOOD PRESSURE REGULATION; BODY MASS; CACAO; CINNAMON; CITRUS; DIASTOLIC BLOOD PRESSURE; DIETARY INTAKE; DYSLIPIDEMIA; ENDOTHELIAL DYSFUNCTION; GLUCOSE BLOOD LEVEL; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LIPID METABOLISM; MEDITERRANEAN DIET; METABOLIC SYNDROME X; NONHUMAN; OBESITY; OXIDATIVE STRESS; SYSTEMATIC REVIEW; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE; BLOOD; BLOOD PRESSURE; DIET; DIETARY SUPPLEMENT; DRUG EFFECTS; METABOLISM; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ANTIOXIDANTS; BLOOD GLUCOSE; BLOOD PRESSURE; DIET; DIETARY SUPPLEMENTS; HUMANS; INSULIN; INSULIN RESISTANCE; METABOLIC SYNDROME X; POLYPHENOLS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84963594659     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/obr.12409     Document Type: Article

References (94)

1. Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 2008; 28: 629-636.
2. Ervin RB. Prevalence of metabolic syndrome among adults 20years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003-2006. Natl Health Stat Report 2009; 5: 1-7.
3. Elks CM, Francis J. Central adiposity, systemic inflammation, and the metabolic syndrome. Curr Hypertens Rep 2010; 12: 99-104.
4. Eckel RH, Alberti KGMM, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2010; 375: 181-183.
5. Macready AL, George TW, Chong MF et al. Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease-FLAVURS: a randomized controlled trial. Am J Clin Nutr 2014; 99: 479-489.
6. Lichtenstein AH, Carson JS, Johnson RK et al. Food-intake patterns assessed by using front-of-pack labeling program criteria associated with better diet quality and lower cardiometabolic risk. Am J Clin Nutr 2014; 99: 454-462.
7. Babio N, Bulló M, Salas-Salvadó J. Mediterranean diet and metabolic syndrome: the evidence. Public Health Nutr 2009; 12: 1607-1617.
8. Esposito K, Marfella R, Ciotola M et al. Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA 2004; 292: 1440-1446.
9. Martínez-González MA, Salas-Salvadó J, Estruch R et al. Benefits of the Mediterranean diet: insights from the PREDIMED study. Prog Cardiovasc Dis 2015; 58: 50-60.
10. Arts ICW, Hollman PCH. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005; 81: 317S-325S.
11. Hooper L, Kroon PA, Rimm EB et al. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2008; 88: 38-50.
12. Hollman PCH, Geelen A, Kromhout D. Dietary flavonol intake may lower stroke risk in men and women. J Nutr 2010; 140: 600-604.
13. Arab L, Liu W, Elashoff D. Green and black tea consumption and risk of stroke: a meta-analysis. Stroke 2009; 40: 1786-1792.
14. Jing Y, Han G, Hu Y, Bi Y, Li L, Zhu D. Tea consumption and risk of type 2 diabetes: a meta-analysis of cohort studies. J Gen Intern Med 2009; 24: 557-562.
15. Cherniack EP. Polyphenols: planting the seeds of treatment for the metabolic syndrome. Nutrition 2011; 27: 617-623.
16. Kassi E, Pervanidou P, Kaltsas G, Chrousos G. Metabolic syndrome: definitions and controversies. BMC Med 2011; 9: 48.
17. Alberti KGMM, Eckel RH, Grundy SM et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009; 120: 1640-1645.
18. Pérez-Jiménez J, Fezeu L, Touvier M et al. Dietary intake of 337 polyphenols in French adults. Am J Clin Nutr 2011; 93: 1220-1228.
19. Zamora-Ros R, Knaze V, Rothwell JA et al. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur J Nutr 2015.
20. Annuzzi G, Bozzetto L, Costabile G et al. Diets naturally rich in polyphenols improve fasting and postprandial dyslipidemia and reduce oxidative stress: a randomized controlled trial. Am J Clin Nutr 2014; 99: 463-471.
21. Nagao T, Komine Y, Soga S et al. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr 2005; 81: 122-129.
22. Basu A, Sanchez K, Leyva MJ et al. Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome. J Am Coll Nutr 2010; 29: 31-40.
23. Basu A, Du M, Sanchez K et al. Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome. Nutrition 2011; 27: 206-213.
24. Chu S-L, Fu H, Yang J-X et al. A randomized double-blind placebo-controlled study of Pu'er tea extract on the regulation of metabolic syndrome. Chin J Integr Med 2011; 17: 492-498.
25. Vieira Senger AE, Schwanke CHA, Gomes I, Valle Gottlieb MG. Effect of green tea (Camellia sinensis) consumption on the components of metabolic syndrome in elderly. J Nutr Health Aging 2012; 16: 738-742.
26. Suliburska J, Bogdanski P, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients. Biol Trace Elem Res 2012; 149: 315-322.
27. Belcaro G, Ledda A, Hu S, Cesarone MR, Feragalli B, Dugall M. Greenselect Phytosome for borderline metabolic syndrome. Evid Based Complement Alternat Med 2013; 2013: 1-7.
28. Yang T-Y, Chou JI, Ueng K-C et al. Weight reduction effect of Puerh tea in male patients with metabolic syndrome. Phytother Res 2014; 28: 1096-1101.
29. Maki KC, Reeves MS, Farmer M et al. Green tea catechin consumption enhances exercise-induced abdominal fat loss in overweight and obese adults. J Nutr 2009; 139: 264-270.
30. Yang T-Y, Chou J-I, Ueng K-C et al. Weight reduction effect of Puerh tea in male patients with metabolic syndrome. Phytother Res 2014; 28: 1096-1101.
31. Davison K, Coates AM, Buckley JD, Howe PRC. Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects. Int J Obes (Lond) 2008; 32: 1289-1296.
32. Berry NM, Davison K, Coates AM, Buckley JD, Howe PRC. Impact of cocoa flavanol consumption on blood pressure responsiveness to exercise. Br J Nutr 2010; 103: 1480-1484.
33. Davison G, Callister R, Williamson G, Cooper KA, Gleeson M. The effect of acute pre-exercise dark chocolate consumption on plasma antioxidant status, oxidative stress and immunoendocrine responses to prolonged exercise. Eur J Nutr 2012; 51: 69-79.
34. D'Anna R, Santamaria A, Cannata ML et al. Effects of a new flavonoid and Myo-inositol supplement on some biomarkers of cardiovascular risk in postmenopausal women: a randomized trial. Int J Endocrinol 2014; 2014: 653561.
35. Broncel M, Kozirog M, Duchnowicz P, Koter-Michalak M, Sikora J, Chojnowska-Jezierska J. Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome. Med Sci Monit 2010; 16: CR28-34.
36. Lehtonen H-M, Suomela J-P, Tahvonen R et al. Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women. Eur J Clin Nutr 2011; 65: 394-401.
37. Stull AJ, Cash KC, Johnson WD, Champagne CM, Cefalu WT. Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women. J Nutr 2010; 140: 1764-1768.
38. Barona J, Blesso CN, Andersen CJ, Park Y, Lee J, Fernandez ML. Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients 2012; 4: 1945-1957.
39. Basu A, Rhone M, Lyons TJ. Berries: emerging impact on cardiovascular health. Nutr Rev 2010; 68: 168-177.
40. Brat P, George S, Bellamy A et al. Daily polyphenol intake in France from fruit and vegetables. J Nutr 2006; 136: 2368-2373.
41. Egert S, Boesch-Saadatmandi C, Wolffram S, Rimbach G, Müller MJ. Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. J Nutr 2010; 140: 278-284.
42. Buchholz T, Melzig M. Polyphenolic Compounds as Pancreatic Lipase Inhibitors. Planta Med 2015; 81: 771-783.
43. Baselga-Escudero L, Pascual-Serrano A, Ribas-Latre A et al. Long-term supplementation with a low dose of proanthocyanidins normalized liver miR-33a and miR-122 levels in high-fat diet-induced obese rats. Nutr Res 2015; 35: 337-345.
44. Rottiers V, Näär AM. MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol 2012; 13: 239-250.
45. Hanhineva K, Törrönen R, Bondia-Pons I et al. Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci 2010; 11: 1365-1402.
46. Mursu J, Virtanen JK, Tuomainen T-P, Nurmi T, Voutilainen S. Intake of fruit, berries, and vegetables and risk of type 2 diabetes in Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr 2014; 99: 328-333.
47. Andriantsitohaina R, Auger C, Chataigneau T et al. Molecular mechanisms of the cardiovascular protective effects of polyphenols. Br J Nutr 2012; 108: 1532-1549.
48. Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda T. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metab Clin Exp 2009; 58: 1743-1746.
49. Chiva-Blanch G, Badimon L, Estruch R. Latest evidence of the effects of the Mediterranean diet in prevention of cardiovascular disease. Curr Atheroscler Rep 2014; 16: 446.
50. Walther G, Obert P, Dutheil F et al. Metabolic syndrome individuals with and without type 2 diabetes mellitus present generalized vascular dysfunction: cross-sectional study. Arterioscler Thromb Vasc Biol 2015; 35(4): 1022-1029.
51. Barona J, Aristizabal JC, Blesso CN, Volek JS, Fernandez ML. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr 2012; 142: 1626-1632.
52. Mulero J, Bernabé J, Cerdá B et al. Variations on cardiovascular risk factors in metabolic syndrome after consume of a citrus-based juice. Clin Nutr 2012; 31: 372-377.
53. Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, Anderson RA. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr 2006; 3: 45-53.
54. Askari F, Rashidkhani B, Hekmatdoost A. Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients. Nutr Res 2014; 34: 143-148.
55. Allison DB, Gadbury G, Schwartz LG et al. A novel soy-based meal replacement formula for weight loss among obese individuals: a randomized controlled clinical trial. Eur J Clin Nutr 2003; 57: 514-522.
56. Usui T, Tochiya M, Sasaki Y et al. Effects of natural S-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status. Clin Endocrinol (Oxf) 2013; 78: 365-372.
57. Romualdi D, Costantini B, Campagna G, Lanzone A, Guido M. Is there a role for soy isoflavones in the therapeutic approach to polycystic ovary syndrome? Results from a pilot study. Fertil Steril 2008; 90: 1826-1833.
58. Egert S, Bosy-Westphal A, Seiberl J et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr 2009; 102: 1065-1074.
59. Rizza S, Muniyappa R, Iantorno M et al. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab 2011; 96: E782-792.
60. Brown AL, Lane J, Coverly J et al. Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br J Nutr 2009; 101: 886-894.
61. Fujitaka K, Otani H, Jo F et al. Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment. Nutr Res 2011; 31: 842-847.
62. Dash S, Xiao C, Morgantini C, Szeto L, Lewis GF. High-dose resveratrol treatment for 2weeks inhibits intestinal and hepatic lipoprotein production in overweight/obese men. Arterioscler Thromb Vasc Biol 2013; 33: 2895-2901.
63. Méndez-del Villar M, González-Ortiz M, Martínez-Abundis E, Pérez-Rubio KG, Lizárraga-Valdez R. Effect of resveratrol administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Metab Syndr Relat Disord 2014; 12: 497-501.
64. Van der Made SM, Plat J, Mensink RP. Resveratrol does not influence metabolic risk markers related to cardiovascular health in overweight and slightly obese subjects: a randomized, placebo-controlled crossover trial. PLoS One 2015; 10: e0118393.
65. Most J, Goossens GH, Jocken JWE, Blaak EE. Short-term supplementation with a specific combination of dietary polyphenols increases energy expenditure and alters substrate metabolism in overweight subjects. Int J Obes (Lond) 2014; 38: 698-706.
66. Phenol-explorer. Database on polyphenol content in foods (http://phenol-explorer.eu)
67. Larsson SC. Coffee, Tea, and Cocoa and Risk of Stroke. Stroke 2014; 45: 309-314.
68. Brown AL, Lane J, Coverly J et al. Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br J Nutr 2009; 101: 886-894.
69. Legeay S, Rodier M, Fillon L, Faure S, Clere N. Epigallocatechin gallate: a review of its beneficial properties to prevent metabolic syndrome. Nutrients 2015; 7: 5443-5468.
70. Dulloo AG, Duret C, Rohrer D et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 1999; 70(6): 1040-5.
71. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord 2000; 24(2): 252-8.
72. Lin J-K, Lin-Shiau S-Y. Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols. Mol Nutr Food Res 2006; 50: 211-217.
73. Yang CS, Zhang J, Zhang L, Huang J, Wang Y. Mechanisms of body weight reduction and metabolic syndrome alleviation by tea. Mol Nutr Food Res 2016; 60: 160-174.
74. Basu A, Fu DX, Wilkinson M et al. Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome. Nutr Res 2010; 30: 462-469.
75. Basu A, Betts NM, Ortiz J, Simmons B, Wu M, Lyons TJ. Low-energy cranberry juice decreases lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome. Nutr Res 2011; 31: 190-196.
76. Li Z, Hong K, Saltsman P et al. Long-term efficacy of soy-based meal replacements vs an individualized diet plan in obese type II DM patients: relative effects on weight loss, metabolic parameters, and C-reactive protein. Eur J Clin Nutr 2005; 59: 411-418.
77. Anderson JW, Fuller J, Patterson K, Blair R, Tabor A. Soy compared to casein meal replacement shakes with energy-restricted diets for obese women: randomized controlled trial. Metab Clin Exp 2007; 56: 280-288.
78. Naaz A, Yellayi S, Zakroczymski MA et al. The soy isoflavone genistein decreases adipose deposition in mice. Endocrinology 2003; 144: 3315-3320.
79. Setchell KDR, Cole SJ. Method of defining equol-producer status and its frequency among vegetarians. J Nutr 2006; 136: 2188-2193.
80. Konings E, Timmers S, Boekschoten MV et al. The effects of 30days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men. Int J Obes (Lond) 2014; 38: 470-473.
81. Moreno-Luna R, Muñoz-Hernandez R, Miranda ML et al. Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. Am J Hypertens 2012; 25: 1299-1304.
82. Petrone AB, Gaziano JM, Djoussé L. Effects of dark chocolate and cocoa products on endothelial function: a meta-analysis. Current Nutrition Reports 2013; 2: 267-273.
83. Cook NR, Cohen J, Hebert PR, Taylor JO, Hennekens CH. Implications of small reductions in diastolic blood pressure for primary prevention. Arch Intern Med 1995; 155: 701-709.
84. Van der Made SM, Plat J, Mensink RP. Resveratrol does not influence metabolic risk markers related to cardiovascular health in overweight and slightly obese subjects: a randomized, placebo-controlled crossover trial. PLoS One 2015; 10: e0118393.
85. Fisher NDL, Hughes M, Gerhard-Herman M, Hollenberg NK. Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens 2003; 21: 2281-2286.
86. Medina-Remón A, Tresserra-Rimbau A, Pons A et al. Effects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial. Nutr Metab Cardiovasc Dis 2015; 25: 60-67.
87. Di Renzo L, Rizzo M, Sarlo F et al. Effects of dark chocolate in a population of normal weight obese women: a pilot study. Eur Rev Med Pharmacol Sci 2013; 17: 2257-2266.
88. Edmands WM, Ferrari P, Rothwell JA et al. Polyphenol metabolome in human urine and its association with intake of polyphenol-rich foods across European countries. Am J Clin Nutr 2015; 102(4): 905-13.
89. Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: an integrative view. Cell 2012; 148: 1258-1270.
90. Tuohy KM, Fava F, Viola R. "The way to a man's heart is through his gut microbiota"-dietary pro- and prebiotics for the management of cardiovascular risk. Proc Nutr Soc 2014; 73: 172-185.
91. Etxeberria U, Fernández-Quintela A, Milagro FI, Aguirre L, Martínez JA, Portillo MP. Impact of polyphenols and polyphenol-rich dietary sources on gut microbiota composition. J Agric Food Chem 2013; 61: 9517-9533.
92. Cardona F, Andrés-Lacueva C, Tulipani S, Tinahones FJ, Queipo-Ortuño MI. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem 2013; 24: 1415-1422.
93. Laparra JM, Sanz Y. Interactions of gut microbiota with functional food components and nutraceuticals. Pharmacol Res 2010; 61: 219-225.
94. Espley RV, Butts CA, Laing WA et al. Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice. J Nutr 2014; 144: 146-154.