메뉴 건너뛰기




Volumn 22, Issue 4, 2017, Pages

Intestinal transport characteristics & metabolism of C-glucosyl dihydrochalcone, aspalathin

Author keywords

Aspalathin; Bioavailability; Caco 2; Metabolism; Transport

Indexed keywords

ASPALATHIN; CHALCONE DERIVATIVE; PLANT EXTRACT;

EID: 85017037390     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules22040554     Document Type: Article
Times cited : (12)

References (50)
  • 1
    • 81255160750 scopus 로고    scopus 로고
    • Rooibos (Aspalathus linearis) beyond the farm gate: From herbal tea to potential phytopharmaceutical
    • CrossRef
    • Joubert, E.; De Beer, D. Rooibos (Aspalathus linearis) beyond the farm gate: From herbal tea to potential phytopharmaceutical. S. Afr. J. Bot. 2011, 77, 869-886. [CrossRef].
    • (2011) S. Afr. J. Bot , vol.77 , pp. 869-886
    • Joubert, E.1    De Beer, D.2
  • 2
    • 85016961829 scopus 로고    scopus 로고
    • Potential of rooibos, its major C-glucosyl flavonoids and Z-2-(D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention of metabolic syndrome
    • CrossRef PubMed
    • Muller, C.J.F.; Malherbe, C.J.; Chellan, N.; Yagasaki, K.; Miura, Y.; Joubert, E. Potential of rooibos, its major C-glucosyl flavonoids and Z-2-(D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention of metabolic syndrome. Crit. Rev. Food Sci. Nutr. 2016. [CrossRef] [PubMed].
    • (2016) Crit. Rev. Food Sci. Nutr
    • Muller, C.J.F.1    Malherbe, C.J.2    Chellan, N.3    Yagasaki, K.4    Miura, Y.5    Joubert, E.6
  • 3
    • 70349634169 scopus 로고    scopus 로고
    • The C-glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans
    • CrossRef PubMed
    • Courts, F.L.; Williamson, G. The C-glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans. Mol. Nutr. Food Res. 2009, 53, 1104-1111. [CrossRef] [PubMed].
    • (2009) Mol. Nutr. Food Res , vol.53 , pp. 1104-1111
    • Courts, F.L.1    Williamson, G.2
  • 4
    • 68249108404 scopus 로고    scopus 로고
    • Bioavailability of C-linked dihydrochalcone and flavanone glucosides in humans following ingestion of unfermented and fermented rooibos teas
    • CrossRef PubMed
    • Stalmach, A.; Mullen, W.; Pecorari, M.; Serafini, M.; Crozier, A. Bioavailability of C-linked dihydrochalcone and flavanone glucosides in humans following ingestion of unfermented and fermented rooibos teas. J. Agric. Food Chem. 2009, 57, 7104-7111. [CrossRef] [PubMed].
    • (2009) J. Agric. Food Chem , vol.57 , pp. 7104-7111
    • Stalmach, A.1    Mullen, W.2    Pecorari, M.3    Serafini, M.4    Crozier, A.5
  • 5
    • 79955618009 scopus 로고    scopus 로고
    • Bioavailability and antioxidant potential of rooibos flavonoids in humans following the consumption of different rooibos formulation
    • s., [CrossRef] [PubMed
    • Breiter, T.; Laue, C.; Kressel, G.; Gröll, S.; Engelhardt, U.H.; Hahn, A. Bioavailability and antioxidant potential of rooibos flavonoids in humans following the consumption of different rooibos formulations. Food Chem. 2011, 128, 338-347. [CrossRef] [PubMed].
    • (2011) Food Chem , vol.128 , pp. 338-347
    • Breiter, T.1    Laue, C.2    Kressel, G.3    Gröll, S.4    Engelhardt, U.H.5    Hahn, A.6
  • 6
    • 4344559467 scopus 로고    scopus 로고
    • The glucose transporter families SGLT and GLUT: Molecular basis of normal and aberrant function
    • CrossRef PubMed
    • Scheepers, A.; Joost, H.G.; Schurmann, A. The glucose transporter families SGLT and GLUT: Molecular basis of normal and aberrant function. J. Parenter. Enter. Nutr. 2004, 28, 364-371. [CrossRef] [PubMed].
    • (2004) J. Parenter. Enter. Nutr. , vol.28 , pp. 364-371
    • Scheepers, A.1    Joost, H.G.2    Schurmann, A.3
  • 8
    • 84955187389 scopus 로고    scopus 로고
    • In silico modeling of aspalathin and nothofagin against SGLT2
    • CrossRef
    • Liu, W.; Wang, H.; Meng, F. In silico modeling of aspalathin and nothofagin against SGLT2. J. Theor. Comput. Chem. 2015, 14, 1550056. [CrossRef].
    • (2015) J. Theor. Comput. Chem , vol.14 , pp. 1550056
    • Liu, W.1    Wang, H.2    Meng, F.3
  • 9
    • 75449091856 scopus 로고    scopus 로고
    • Apple trees to sodium glucose co-Transporter inhibitors: A review of SGLT2 inhibition
    • CrossRef
    • White, J.R. Apple trees to sodium glucose co-Transporter inhibitors: A review of SGLT2 inhibition. Clin. Diabetes 2010, 28, 5-10. [CrossRef].
    • (2010) Clin. Diabetes , vol.28 , pp. 5-10
    • White, J.R.1
  • 10
    • 85013827723 scopus 로고    scopus 로고
    • The occurrence, fate and biological activities of C-glycosyl flavonoids in the human diet
    • CrossRef PubMed
    • Courts, F.L.; Williamson, G. The occurrence, fate and biological activities of C-glycosyl flavonoids in the human diet. Crit. Rev. Food Sci. Nutr. 2013, 8398, 37-41. [CrossRef] [PubMed].
    • (2013) Crit. Rev. Food Sci. Nutr. , vol.8398 , pp. 37-41
    • Courts, F.L.1    Williamson, G.2
  • 11
    • 64449086955 scopus 로고    scopus 로고
    • Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice
    • CrossRef PubMed
    • Kawano, A.; Nakamura, H.; Hata, S.; Minakawa, M.; Miura, Y.; Yagasaki, K. Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice. Phytomedicine 2009, 16, 437-443. [CrossRef] [PubMed].
    • (2009) Phytomedicine , vol.16 , pp. 437-443
    • Kawano, A.1    Nakamura, H.2    Hata, S.3    Minakawa, M.4    Miura, Y.5    Yagasaki, K.6
  • 12
    • 84891836160 scopus 로고    scopus 로고
    • Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice
    • CrossRef
    • Son, M.J.; Minakawa, M.; Miura, Y.; Yagasaki, K. Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice. Eur. J. Nutr. 2013, 52, 1607-1619. [CrossRef].
    • (2013) Eur. J. Nutr , vol.52 , pp. 1607-1619
    • Son, M.J.1    Minakawa, M.2    Miura, Y.3    Yagasaki, K.4
  • 13
    • 65549103408 scopus 로고    scopus 로고
    • Predicting pharmacokinetics of drugs using physiologically based modeling-Application to food effects
    • CrossRef PubMed
    • Parrott, N.; Lukacova, V.; Fraczkiewicz, G.; Bolger, M.B. Predicting pharmacokinetics of drugs using physiologically based modeling-Application to food effects. AAPS J. 2009, 11, 45-53. [CrossRef] [PubMed].
    • (2009) AAPS J. , vol.11 , pp. 45-53
    • Parrott, N.1    Lukacova, V.2    Fraczkiewicz, G.3    Bolger, M.B.4
  • 14
    • 27944473041 scopus 로고    scopus 로고
    • Mass spectrometric identification and quantification of glycosyl flavonoids, including dihydrochalcones with neutral loss scan mode
    • CrossRef PubMed
    • Kazuno, S.; Yanagida, M.; Shindo, N.; Murayama, K. Mass spectrometric identification and quantification of glycosyl flavonoids, including dihydrochalcones with neutral loss scan mode. Anal. Biochem. 2005, 347, 182-192. [CrossRef] [PubMed].
    • (2005) Anal. Biochem , vol.347 , pp. 182-192
    • Kazuno, S.1    Yanagida, M.2    Shindo, N.3    Murayama, K.4
  • 15
    • 68249097567 scopus 로고    scopus 로고
    • Phenolic contribution of South African herbal teas to a healthy diet
    • PubMed
    • Joubert, E.; Gelderblom, W.C.A.; De Beer, D. Phenolic contribution of South African herbal teas to a healthy diet. Nat. Prod. Commun. 2009, 4, 701-718. [PubMed].
    • (2009) Nat. Prod. Commun , vol.4 , pp. 701-718
    • Joubert, E.1    Gelderblom, W.C.A.2    De Beer, D.3
  • 16
    • 84946478501 scopus 로고    scopus 로고
    • Predicting clearance mechanism in drug discovery: Extended Clearance Classification System (ECCS)
    • CrossRef PubMed
    • Varma, M.V.; Steyn, S.J.; Allerton, C.; El-Kattan, A.F. Predicting clearance mechanism in drug discovery: Extended Clearance Classification System (ECCS). Pharm. Res. 2015, 32, 3785-3802. [CrossRef] [PubMed].
    • (2015) Pharm. Res. , vol.32 , pp. 3785-3802
    • Varma, M.V.1    Steyn, S.J.2    Allerton, C.3    El-Kattan, A.F.4
  • 17
    • 79551480499 scopus 로고    scopus 로고
    • Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium
    • CrossRef PubMed
    • Braune, A.; Blaut, M. Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium. Environ. Microbiol. 2011, 13, 482-494. [CrossRef] [PubMed].
    • (2011) Environ. Microbiol , vol.13 , pp. 482-494
    • Braune, A.1    Blaut, M.2
  • 18
    • 84870428902 scopus 로고    scopus 로고
    • Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential
    • CrossRef PubMed
    • Muller, C.J.F.; Joubert, E.; De Beer, D.; Sanderson, M.; Malherbe, C.J.; Fey, S.J.; Louw, J. Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential. Phytomedicine 2012, 20, 32-39. [CrossRef] [PubMed].
    • (2012) Phytomedicine , vol.20 , pp. 32-39
    • Muller, C.J.F.1    Joubert, E.2    De Beer, D.3    Sanderson, M.4    Malherbe, C.J.5    Fey, S.J.6    Louw, J.7
  • 20
    • 53449087260 scopus 로고    scopus 로고
    • Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside
    • CrossRef PubMed
    • Kreuz, S.; Joubert, E.; Waldmann, K.H.; Ternes, W. Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside. Nutr. Res. 2008, 28, 690-701. [CrossRef] [PubMed].
    • (2008) Nutr. Res. , vol.28 , pp. 690-701
    • Kreuz, S.1    Joubert, E.2    Waldmann, K.H.3    Ternes, W.4
  • 21
    • 77249093563 scopus 로고    scopus 로고
    • In vitro hepatic biotransformation of aspalathin and nothofagin, dihydrochalcones of rooibos (Aspalathus linearis), and assessment of metabolite antioxidant activity
    • CrossRef PubMed
    • Van der Merwe, J.D.; Joubert, E.; Manley, M.; De Beer, D.; Malherbe, C.J.; Gelderblom, W.C.A. In vitro hepatic biotransformation of aspalathin and nothofagin, dihydrochalcones of rooibos (Aspalathus linearis), and assessment of metabolite antioxidant activity. J. Agric. Food Chem. 2010, 58, 2214-2220. [CrossRef] [PubMed].
    • (2010) J. Agric. Food Chem , vol.58 , pp. 2214-2220
    • Van Der Merwe, J.D.1    Joubert, E.2    Manley, M.3    De Beer, D.4    Malherbe, C.J.5    Gelderblom, W.C.A.6
  • 24
    • 78649674647 scopus 로고    scopus 로고
    • Application of method suitability for drug permeability classification
    • CrossRef PubMed
    • Volpe, D.A. Application of method suitability for drug permeability classification. AAPS J. 2010, 12, 670-678. [CrossRef] [PubMed].
    • (2010) AAPS J. , vol.12 , pp. 670-678
    • Volpe, D.A.1
  • 25
    • 84871436009 scopus 로고    scopus 로고
    • Paracellular drug absorption enhancement through tight junction modulation
    • CrossRef PubMed
    • Lemmer, H.J.R.; Hamman, J.H. Paracellular drug absorption enhancement through tight junction modulation. Expert Opin. Drug Deliv. 2013, 10, 103-114. [CrossRef] [PubMed].
    • (2013) Expert Opin. Drug Deliv , vol.10 , pp. 103-114
    • Lemmer, H.J.R.1    Hamman, J.H.2
  • 26
    • 0032410164 scopus 로고    scopus 로고
    • Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors
    • CrossRef PubMed
    • Van de Waterbeemd, H.; Camenisch, G.; Folkers, G.; Chretien, J.R.; Raevsky, O.A. Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors. J. Drug Target. 1998, 6, 151-165. [CrossRef] [PubMed].
    • (1998) J. Drug Target , vol.6 , pp. 151-165
    • Van De Waterbeemd, H.1    Camenisch, G.2    Folkers, G.3    Chretien, J.R.4    Raevsky, O.A.5
  • 27
    • 0032190504 scopus 로고    scopus 로고
    • Shapes of membrane permeability-lipophilicity curves: Extension of theoretical models with an aqueous pore pathway
    • CrossRef
    • Camenisch, G.; Folkers, G.; Van de Waterbeemd, H. Shapes of membrane permeability-lipophilicity curves: Extension of theoretical models with an aqueous pore pathway. Eur. J. Pharm. Sci. 1998, 6, 321-329. [CrossRef].
    • (1998) Eur. J. Pharm. Sci , vol.6 , pp. 321-329
    • Camenisch, G.1    Folkers, G.2    Van De Waterbeemd, H.3
  • 29
    • 84933673955 scopus 로고    scopus 로고
    • Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease
    • CrossRef PubMed
    • Lerner, A.; Matthias, T. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Autoimmun. Rev. 2015, 14, 479-489. [CrossRef] [PubMed].
    • (2015) Autoimmun. Rev , vol.14 , pp. 479-489
    • Lerner, A.1    Matthias, T.2
  • 30
    • 0035320037 scopus 로고    scopus 로고
    • Multifunctional strands in tight junctions
    • CrossRef PubMed
    • Tsukita, S.; Furuse, M.; Itoh, M. Multifunctional strands in tight junctions. Nat. Rev. Mol. Cell Biol. 2001, 2, 285-293. [CrossRef] [PubMed].
    • (2001) Nat. Rev. Mol. Cell Biol , vol.2 , pp. 285-293
    • Tsukita, S.1    Furuse, M.2    Itoh, M.3
  • 31
    • 0027744129 scopus 로고
    • Occludin: A novel integral membrane protein localizing at tight junctions
    • CrossRef PubMed
    • Furuse, M.; Hirase, T.; Itoh, M.; Nagafuchi, A.; Yonemura, S.; Tsukita, S.; Tsukita, S. Occludin: A novel integral membrane protein localizing at tight junctions. J. Cell Biol. 1993, 123, 1777-1788. [CrossRef] [PubMed].
    • (1993) J. Cell Biol. , vol.123 , pp. 1777-1788
    • Furuse, M.1    Hirase, T.2    Itoh, M.3    Nagafuchi, A.4    Yonemura, S.5    Tsukita, S.6    Tsukita, S.7
  • 32
    • 0033582334 scopus 로고    scopus 로고
    • Claudin multigene family encoding four-Transmembrane domain protein components of tight junction strands
    • CrossRef PubMed
    • Morita, K.; Furuse, M.; Fujimoto, K.; Tsukita, S. Claudin multigene family encoding four-Transmembrane domain protein components of tight junction strands. Proc. Natl. Acad. Sci. USA 1999, 96, 511-516. [CrossRef] [PubMed].
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 511-516
    • Morita, K.1    Furuse, M.2    Fujimoto, K.3    Tsukita, S.4
  • 33
    • 15744362477 scopus 로고    scopus 로고
    • Junctional adhesion molecule 1 regulates epithelial cell morphology through effects on beta1 integrins and Rap1 activity
    • CrossRef PubMed
    • Mandell, K.J.; Babbin, B.A.; Nusrat, A.; Parkos, C.A. Junctional adhesion molecule 1 regulates epithelial cell morphology through effects on beta1 integrins and Rap1 activity. J. Biol. Chem. 2005, 280, 11665-11674. [CrossRef] [PubMed].
    • (2005) J. Biol. Chem. , vol.280 , pp. 11665-11674
    • Mandell, K.J.1    Babbin, B.A.2    Nusrat, A.3    Parkos, C.A.4
  • 34
    • 29144533473 scopus 로고    scopus 로고
    • Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
    • CrossRef PubMed
    • Ikenouchi, J.; Furuse, M.; Furuse, K.; Sasaki, H.; Tsukita, S.; Tsukita, S. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J. Cell Biol. 2005, 171, 939-945. [CrossRef] [PubMed].
    • (2005) J. Cell Biol. , vol.171 , pp. 939-945
    • Ikenouchi, J.1    Furuse, M.2    Furuse, K.3    Sasaki, H.4    Tsukita, S.5    Tsukita, S.6
  • 35
    • 84878340773 scopus 로고    scopus 로고
    • Nanoparticle-induced tight-junction opening for the transport of an anti-Angiogenic sulfated polysaccharide across Caco-2 cell monolayers
    • CrossRef PubMed
    • Yu, S.H.; Tang, D.W.; Hsieh, H.Y.;Wu, W.S.; Lin, B.X.; Chuang, E.Y.; Sung, H.W.; Mi, F.L. Nanoparticle-induced tight-junction opening for the transport of an anti-Angiogenic sulfated polysaccharide across Caco-2 cell monolayers. Acta Biomater. 2013, 9, 7449-7459. [CrossRef] [PubMed].
    • (2013) Acta Biomater , vol.9 , pp. 7449-7459
    • Yu, S.H.1    Tang, D.W.2    Hsieh, H.Y.3    Wu, W.S.4    Lin, B.X.5    Chuang, E.Y.6    Sung, H.W.7    Mi, F.L.8
  • 37
    • 44149111085 scopus 로고    scopus 로고
    • Transport of aspalathin, a rooibos tea flavonoid, across the skin and intestinal epithelium
    • CrossRef PubMed
    • Huang, M.; Du Plessis, J.; Du Preez, J.; Hamman, J.; Viljoen, A. Transport of aspalathin, a rooibos tea flavonoid, across the skin and intestinal epithelium. Phyther. Res. 2008, 22, 699-704. [CrossRef] [PubMed].
    • (2008) Phyther. Res , vol.22 , pp. 699-704
    • Huang, M.1    Du Plessis, J.2    Du Preez, J.3    Hamman, J.4    Viljoen, A.5
  • 38
    • 84978219606 scopus 로고    scopus 로고
    • In vitro study of UGT metabolism and permeability of orientin and isoorientin, two active flavonoid C-glycosides
    • CrossRef PubMed
    • Shi, J.; Zhu, L.; Li, Y.; Zheng, H.; Yu, J.; Lu, L.; Liu, Z. In vitro study of UGT metabolism and permeability of orientin and isoorientin, two active flavonoid C-glycosides. Drug Metab. Lett. 2016, 10, 101-110. [CrossRef] [PubMed].
    • (2016) Drug Metab. Lett , vol.10 , pp. 101-110
    • Shi, J.1    Zhu, L.2    Li, Y.3    Zheng, H.4    Yu, J.5    Lu, L.6    Liu, Z.7
  • 39
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • CrossRef PubMed
    • Hotamisligil, G.S. Inflammation and metabolic disorders. Nature 2006, 444, 860-867. [CrossRef] [PubMed].
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 40
    • 84937252261 scopus 로고    scopus 로고
    • Anti-inflammatory effects of aspalathin and nothofagin from rooibos (Aspalathus linearis) in vitro and in vivo
    • CrossRef PubMed
    • Lee, W.; Bae, J.S. Anti-inflammatory effects of aspalathin and nothofagin from rooibos (Aspalathus linearis) in vitro and in vivo. Inflammation 2015, 38, 1502-1516. [CrossRef] [PubMed].
    • (2015) Inflammation , vol.38 , pp. 1502-1516
    • Lee, W.1    Bae, J.S.2
  • 42
    • 84922781289 scopus 로고    scopus 로고
    • Isolation of aspalathin and nothofagin from rooibos (Aspalathus linearis) using high-performance countercurrent chromatography: Sample loading and compound stability considerations
    • CrossRef PubMed
    • De Beer, D.; Malherbe, C.J.; Beelders, T.; Willenburg, E.L.; Brand, D.J.; Joubert, E. Isolation of aspalathin and nothofagin from rooibos (Aspalathus linearis) using high-performance countercurrent chromatography: Sample loading and compound stability considerations. J. Chromatogr. A 2015, 1381, 29-36. [CrossRef] [PubMed].
    • (2015) J. Chromatogr. a , vol.1381 , pp. 29-36
    • De Beer, D.1    Malherbe, C.J.2    Beelders, T.3    Willenburg, E.L.4    Brand, D.J.5    Joubert, E.6
  • 43
    • 77955509080 scopus 로고    scopus 로고
    • Getting physical in drug discovery: A contemporary perspective on solubility and hydrophobicity
    • CrossRef PubMed
    • Hill, A.P.; Young, R.J. Getting physical in drug discovery: A contemporary perspective on solubility and hydrophobicity. Drug Discov. Today 2010, 15, 648-655. [CrossRef] [PubMed].
    • (2010) Drug Discov. Today , vol.15 , pp. 648-655
    • Hill, A.P.1    Young, R.J.2
  • 44
    • 76949100912 scopus 로고    scopus 로고
    • A high throughput dried DMSO Log D lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection
    • CrossRef PubMed
    • Alelyunas, Y.W.; Pelosi-kilby, L.; Turcotte, P.; Kary, M.; Spreen, R.C. A high throughput dried DMSO Log D lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection. J. Chromatogr. A 2010, 1217, 1950-1955. [CrossRef] [PubMed].
    • (2010) J. Chromatogr. a , vol.1217 , pp. 1950-1955
    • Alelyunas, Y.W.1    Pelosi-Kilby, L.2    Turcotte, P.3    Kary, M.4    Spreen, R.C.5
  • 45
    • 77349090680 scopus 로고    scopus 로고
    • Caco-2 cells and Biopharmaceutics Classification System (BCS) for prediction of transepithelial transport of xenobiotics (model drug: Caffeine)
    • PubMed
    • Smetanova, L.; Stetinova, V.; Kholova, D.; Kvetina, J.; Smetana, J.; Svoboda, Z. Caco-2 cells and Biopharmaceutics Classification System (BCS) for prediction of transepithelial transport of xenobiotics (model drug: Caffeine). Neuro Endocrinol. Lett. 2009, 30 (Suppl. 1), 101-105. [PubMed].
    • (2009) Neuro Endocrinol. Lett. , vol.30 , pp. 101-105
    • Smetanova, L.1    Stetinova, V.2    Kholova, D.3    Kvetina, J.4    Smetana, J.5    Svoboda, Z.6
  • 46
    • 14844303448 scopus 로고    scopus 로고
    • Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells
    • CrossRef PubMed
    • Johnston, K.; Sharp, P.; Clifford, M.N.; Morgan, L. Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells. FEBS Lett. 2005, 579, 1653-1657. [CrossRef] [PubMed].
    • (2005) FEBS Lett , vol.579 , pp. 1653-1657
    • Johnston, K.1    Sharp, P.2    Clifford, M.N.3    Morgan, L.4
  • 48
    • 0025804183 scopus 로고
    • Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
    • CrossRef
    • Artursson, P.; Karlsson, J. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun. 1991, 175, 880-885. [CrossRef].
    • (1991) Biochem. Biophys. Res. Commun , vol.175 , pp. 880-885
    • Artursson, P.1    Karlsson, J.2
  • 49
    • 1842557505 scopus 로고    scopus 로고
    • Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers
    • CrossRef PubMed
    • Ingels, F.; Beck, B.; Oth, M.; Augustijns, P. Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers. Int. J. Pharm. 2004, 274, 221-232. [CrossRef] [PubMed].
    • (2004) Int. J. Pharm. , vol.274 , pp. 221-232
    • Ingels, F.1    Beck, B.2    Oth, M.3    Augustijns, P.4
  • 50
    • 38449084547 scopus 로고    scopus 로고
    • Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
    • CrossRef PubMed
    • Hubatsch, I.; Ragnarsson, E.G.E.; Artursson, P. Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers. Nat. Protoc. 2007, 2, 2111-2119. [CrossRef] [PubMed].
    • (2007) Nat. Protoc. , vol.2 , pp. 2111-2119
    • Hubatsch, I.1    Ragnarsson, E.G.E.2    Artursson, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.