메뉴 건너뛰기




Volumn 7, Issue 3, 2003, Pages 402-408

Profiling drug-like properties in discovery research

Author keywords

[No Author keywords available]

Indexed keywords

7 BENZYLOXY 4 (TRIFLUOROMETHYL)COUMARIN; COUMARIN DERIVATIVE; CYTOCHROME P450 INHIBITOR; UNCLASSIFIED DRUG;

EID: 0037523454     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(03)00055-3     Document Type: Review
Times cited : (253)

References (55)
  • 1
    • 0034002261 scopus 로고    scopus 로고
    • Role of the development scientist in compound lead selection and optimization
    • A key milestone that illuminates the contributions that development experience can make to discovery, to improve candidate readiness for development
    • Venkatesh S., Lipper R.A. Role of the development scientist in compound lead selection and optimization. J. Pharm. Sci. 89:2000;145-154 A key milestone that illuminates the contributions that development experience can make to discovery, to improve candidate readiness for development.
    • (2000) J. Pharm. Sci. , vol.89 , pp. 145-154
    • Venkatesh, S.1    Lipper, R.A.2
  • 2
    • 0036372804 scopus 로고    scopus 로고
    • High-throughput screening - brain versus brawn
    • An excellent article on issues and challenges facing today's drug discovery
    • Smith D.A. High-throughput screening - brain versus brawn. Ernst Schering Research Foundation Workshop. 37:2002;203-212 An excellent article on issues and challenges facing today's drug discovery.
    • (2002) Ernst Schering Research Foundation Workshop , vol.37 , pp. 203-212
    • Smith, D.A.1
  • 3
    • 0035150465 scopus 로고    scopus 로고
    • High throughput physicochemical profiling for drug discovery
    • Review of current high-throughput profiling assays for physicochemical properties
    • Kerns E.H. High throughput physicochemical profiling for drug discovery. J. Pharm. Sci. 90:2001;1838-1858 Review of current high-throughput profiling assays for physicochemical properties.
    • (2001) J. Pharm. Sci. , vol.90 , pp. 1838-1858
    • Kerns, E.H.1
  • 4
    • 0002041834 scopus 로고    scopus 로고
    • Multivariate pharmaceutical profiling for drug discovery
    • Kerns E.H., Di L. Multivariate pharmaceutical profiling for drug discovery. Curr. Topics Med. Chem. 2:2002;87-98.
    • (2002) Curr. Topics Med. Chem. , vol.2 , pp. 87-98
    • Kerns, E.H.1    Di, L.2
  • 5
    • 0035523337 scopus 로고    scopus 로고
    • Metabolism profiling and cytochrome P450 inhibition & induction in drug discovery
    • A thorough summary of current strategies in pharmacokinetics, toxicokinetics, drug metabolism, and drug-drug interaction for profiling drug discovery candidates
    • Yan Z., Caldwell G.W. Metabolism profiling and cytochrome P450 inhibition & induction in drug discovery. Curr. Topics Med. Chem. 1:2001;403-425 A thorough summary of current strategies in pharmacokinetics, toxicokinetics, drug metabolism, and drug-drug interaction for profiling drug discovery candidates.
    • (2001) Curr. Topics Med. Chem. , vol.1 , pp. 403-425
    • Yan, Z.1    Caldwell, G.W.2
  • 6
    • 0035415865 scopus 로고    scopus 로고
    • Screening of drug candidates for their drug-drug interaction potential
    • Key insights on the motivation, procedures and application of drug-drug interaction monitoring in drug discovery
    • Rodrigues A.D., Lin J.H. Screening of drug candidates for their drug-drug interaction potential. Curr. Opin. Chem. Biol. 5:2001;396-401 Key insights on the motivation, procedures and application of drug-drug interaction monitoring in drug discovery.
    • (2001) Curr. Opin. Chem. Biol. , vol.5 , pp. 396-401
    • Rodrigues, A.D.1    Lin, J.H.2
  • 7
    • 0035953319 scopus 로고    scopus 로고
    • Property-based design: Optimization of drug absorption and pharmacokinetics
    • The authors introduce the concept of property-based design and provide a broad-ranging discussions on designing drugs with optimal drug-like properties
    • van de Waterbeemd H., Smith D.A., Beaumont K., Walker D.K. Property-based design: optimization of drug absorption and pharmacokinetics. J. Med. Chem. 44:2001;1313-1333 The authors introduce the concept of property-based design and provide a broad-ranging discussions on designing drugs with optimal drug-like properties.
    • (2001) J. Med. Chem. , vol.44 , pp. 1313-1333
    • Van de Waterbeemd, H.1    Smith, D.A.2    Beaumont, K.3    Walker, D.K.4
  • 8
    • 0037061628 scopus 로고    scopus 로고
    • A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
    • McGovern S.L., Caselli E., Grigorieff N., Shoichet B.K. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J. Med. Chem. 45:2002;1712-1722.
    • (2002) J. Med. Chem. , vol.45 , pp. 1712-1722
    • McGovern, S.L.1    Caselli, E.2    Grigorieff, N.3    Shoichet, B.K.4
  • 9
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • Outstanding article on the correlation of lead-generation strategies (HTS and rational design) with their effects on the solubility and permeability of discovery candidates
    • Lipinski C.A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharm. Tox. Methods. 44:2000;235-249 Outstanding article on the correlation of lead-generation strategies (HTS and rational design) with their effects on the solubility and permeability of discovery candidates.
    • (2000) J. Pharm. Tox. Methods , vol.44 , pp. 235-249
    • Lipinski, C.A.1
  • 10
    • 0002510887 scopus 로고    scopus 로고
    • Avoiding investment in doomed drugs
    • Lipinski C.A. Avoiding investment in doomed drugs. Curr. Drug Disc. April:2001;17-19.
    • (2001) Curr. Drug Disc. , vol.APRIL , pp. 17-19
    • Lipinski, C.A.1
  • 11
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Landmark article on solubility, its effects on drug discovery research, and the highly effective 'rule of 5' for drug-like properties
    • Lipinski C.A., Lombardo F., Dominy B.W., Feeney P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Delivery Rev. 46:2001;3-26 Landmark article on solubility, its effects on drug discovery research, and the highly effective 'rule of 5' for drug-like properties.
    • (2001) Adv. Drug Delivery Rev. , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 12
    • 0034655372 scopus 로고    scopus 로고
    • A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates
    • Bevan C.D., Lloyd R.S. A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates. Anal. Chem. 72:2000;1781-1787.
    • (2000) Anal. Chem. , vol.72 , pp. 1781-1787
    • Bevan, C.D.1    Lloyd, R.S.2
  • 13
    • 0035468033 scopus 로고    scopus 로고
    • Physicochemical profiling (solubility, permeability and charge state)
    • A detailed treatise on the fundamentals of key physicochemical properties, how these properties affect drug interaction with biological systems, and drug absorption
    • Avdeef A. Physicochemical profiling (solubility, permeability and charge state). Curr. Topics Med. Chem. 1:2001;277-351 A detailed treatise on the fundamentals of key physicochemical properties, how these properties affect drug interaction with biological systems, and drug absorption.
    • (2001) Curr. Topics Med. Chem. , vol.1 , pp. 277-351
    • Avdeef, A.1
  • 14
    • 0035069173 scopus 로고    scopus 로고
    • Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility
    • Pan L., Ho Q., Tsutsui K., Takahashi L. Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility. J. Pharm. Sci. 90:2001;521-529.
    • (2001) J. Pharm. Sci. , vol.90 , pp. 521-529
    • Pan, L.1    Ho, Q.2    Tsutsui, K.3    Takahashi, L.4
  • 15
    • 0036828814 scopus 로고    scopus 로고
    • Evaluation of method for high throughput solubility determination using a multi-wavelength UV plate reader
    • Chen T.M., Shen H., Zhu C. Evaluation of method for high throughput solubility determination using a multi-wavelength UV plate reader. Comb. Chem. High Throughput Screen. 5:2002;575-581.
    • (2002) Comb. Chem. High Throughput Screen , vol.5 , pp. 575-581
    • Chen, T.M.1    Shen, H.2    Zhu, C.3
  • 16
    • 0035286778 scopus 로고    scopus 로고
    • Caco-2 monolayers in experimental and theoretical predictions of drug transport
    • Artursson P., Palm K., Luthman K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv. Drug Deliv. Rev. 46:2001;27-43.
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , pp. 27-43
    • Artursson, P.1    Palm, K.2    Luthman, K.3
  • 19
    • 0032568397 scopus 로고    scopus 로고
    • Physicochemical high throughput screening: Parallel artificial membrane permeation assay in the description of passive absorption processes
    • Kansy M., Senner F., Gubernator K. Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. J. Med. Chem. 41:1998;1007-1010.
    • (1998) J. Med. Chem. , vol.41 , pp. 1007-1010
    • Kansy, M.1    Senner, F.2    Gubernator, K.3
  • 20
    • 0035866672 scopus 로고    scopus 로고
    • High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes
    • Wohnsland F., Faller B. High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. J. Med. Chem. 44:2001;923-930.
    • (2001) J. Med. Chem. , vol.44 , pp. 923-930
    • Wohnsland, F.1    Faller, B.2
  • 21
    • 0037173513 scopus 로고    scopus 로고
    • Prediction of total passive permeation using bio-mimetic artificial membrane permeability and paracellular pathway model
    • Sugano K., Takata N., Machida M., Saitoh K. Prediction of total passive permeation using bio-mimetic artificial membrane permeability and paracellular pathway model. J. Pharm. Sci. Tech. Japan. 62:2002;241.
    • (2002) J. Pharm. Sci. Tech. Japan , vol.62 , pp. 241
    • Sugano, K.1    Takata, N.2    Machida, M.3    Saitoh, K.4
  • 22
    • 0036238280 scopus 로고    scopus 로고
    • A comparative study of artificial permeability assay for high throughput profiling of drug absorption potential
    • Zhu C., Jiang L., Chen T.M., Hwang K.K. A comparative study of artificial permeability assay for high throughput profiling of drug absorption potential. Eur. J. Med. Chem. 37:2002;399-407.
    • (2002) Eur. J. Med. Chem. , vol.37 , pp. 399-407
    • Zhu, C.1    Jiang, L.2    Chen, T.M.3    Hwang, K.K.4
  • 23
    • 84962359573 scopus 로고    scopus 로고
    • High throughput artificial membrane permeability assay for blood-brain barrier
    • in press
    • Di L, Kerns EH, Fan K, McConnell OJ, Carter G: High throughput artificial membrane permeability assay for blood-brain barrier. Eur J Med Chem 2003, in press.
    • (2003) Eur J Med Chem
    • Di, L.1    Kerns, E.H.2    Fan, K.3    McConnell, O.J.4    Carter, G.5
  • 24
    • 0035478419 scopus 로고    scopus 로고
    • The drug efflux-metabolism alliance: Biochemical aspects
    • Benet L.Z., Cummins C.L. The drug efflux-metabolism alliance: biochemical aspects. Adv. Drug Deliv. Rev. 50(Suppl 1):2001;S3-11.
    • (2001) Adv. Drug Deliv. Rev. , vol.50 , Issue.SUPPL. 1 , pp. 3-11
    • Benet, L.Z.1    Cummins, C.L.2
  • 26
    • 0037171818 scopus 로고    scopus 로고
    • A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein
    • Penzotti J.E., Lamb M.L., Evensen E., Grootenhuis D.J. A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein. J. Med. Chem. 45:2002;1737-1740.
    • (2002) J. Med. Chem. , vol.45 , pp. 1737-1740
    • Penzotti, J.E.1    Lamb, M.L.2    Evensen, E.3    Grootenhuis, D.J.4
  • 28
    • 13244293644 scopus 로고    scopus 로고
    • High throughput measurement of Log D and pKa
    • Edited by van de Waterbeemd H, Lennernas H, Artursson P. Weinheim: Wiley-VCH; in press
    • Comer JEA: High throughput measurement of Log D and pKa. In Drug Bioavailability. Estimation of Solubility, Permeability and Absorption. Edited by van de Waterbeemd H, Lennernas H, Artursson P. Weinheim: Wiley-VCH; in press.
    • Drug Bioavailability. Estimation of Solubility, Permeability and Absorption
    • Comer, J.E.A.1
  • 29
    • 0034493887 scopus 로고    scopus 로고
    • An increased throughput method for the determination of partition coefficients
    • Hitzel L., Watt A.P., Locker K.L. An increased throughput method for the determination of partition coefficients. Pharm. Res. 17:2000;1389-1395.
    • (2000) Pharm. Res. , vol.17 , pp. 1389-1395
    • Hitzel, L.1    Watt, A.P.2    Locker, K.L.3
  • 30
    • 0036804586 scopus 로고    scopus 로고
    • Relative hydrophobicity and lipophilicity of β-blockers and related compounds as measured by aqueous two-phase partitioning, octanol-buffer partitioning, and HPLC
    • Gulyaeva N., Zaslavsky A., Lechner P., Chlenov M., Chait A., Zaslavsky B. Relative hydrophobicity and lipophilicity of β-blockers and related compounds as measured by aqueous two-phase partitioning, octanol-buffer partitioning, and HPLC. Eur. J. Pharm. Sci. 17:2002;81-93.
    • (2002) Eur. J. Pharm. Sci. , vol.17 , pp. 81-93
    • Gulyaeva, N.1    Zaslavsky, A.2    Lechner, P.3    Chlenov, M.4    Chait, A.5    Zaslavsky, B.6
  • 31
    • 0035913059 scopus 로고    scopus 로고
    • ElogD(oct): A tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds
    • Lombardo F., Shalaeva M.Y., Tupper K.A., Gao F. ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. J. Med. Chem. 44:2001;2490-2497.
    • (2001) J. Med. Chem. , vol.44 , pp. 2490-2497
    • Lombardo, F.1    Shalaeva, M.Y.2    Tupper, K.A.3    Gao, F.4
  • 32
    • 0034929926 scopus 로고    scopus 로고
    • Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention and a hydrogen bond acidity term (Σα2H)
    • Valko K., Du C.M., Bevan C., Reynolds D.P., Abraham M.H. Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention and a hydrogen bond acidity term (Σα2H). Curr. Med. Chem. 8:2001;1137-1146.
    • (2001) Curr. Med. Chem. , vol.8 , pp. 1137-1146
    • Valko, K.1    Du, C.M.2    Bevan, C.3    Reynolds, D.P.4    Abraham, M.H.5
  • 34
    • 0033384221 scopus 로고    scopus 로고
    • Prediction of distribution coefficients from structure. Comparison of calculated and experimental data for various drugs
    • Tsantili-Kakoulidou A, Panderi I, Piperaki S, Csizmadia F, Darvas F: Prediction of distribution coefficients from structure. Comparison of calculated and experimental data for various drugs. Eur J Drug Metab Pharmacokin 1999, 24:205-212. On World Wide Web URL: http://www.ahsystem.com/compudrug.html .
    • (1999) Eur J Drug Metab Pharmacokin , vol.24 , pp. 205-212
    • Tsantili-Kakoulidou, A.1    Panderi, I.2    Piperaki, S.3    Csizmadia, F.4    Darvas, F.5
  • 35
    • 0034256965 scopus 로고    scopus 로고
    • On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: Towards the prediction of human P450 substrate specificity and metabolism
    • Lewis D.F.V. On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: towards the prediction of human P450 substrate specificity and metabolism. Biochem. Pharmacol. 60:2000;293-306.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 293-306
    • Lewis, D.F.V.1
  • 36
    • 85031154214 scopus 로고    scopus 로고
    • High throughput measurement of pKa values in a mixed-buffer linear pH gradient system
    • in press
    • Box K, Bevan C, Comer J, Hill A, Allen R, Reynolds D: High throughput measurement of pKa values in a mixed-buffer linear pH gradient system. Anal Chem, in press.
    • Anal Chem
    • Box, K.1    Bevan, C.2    Comer, J.3    Hill, A.4    Allen, R.5    Reynolds, D.6
  • 37
    • 0036017359 scopus 로고    scopus 로고
    • A rapid method for pKa determination of drugs using pressure-assisted capillary electrophoresis with photodiode array detection in drug discovery
    • Ishihama Y., Nakamura M., Miwa T., Kajima T., Asakawa N. A rapid method for pKa determination of drugs using pressure-assisted capillary electrophoresis with photodiode array detection in drug discovery. J. Pharm. Sci. 91:2002;933-942.
    • (2002) J. Pharm. Sci. , vol.91 , pp. 933-942
    • Ishihama, Y.1    Nakamura, M.2    Miwa, T.3    Kajima, T.4    Asakawa, N.5
  • 38
  • 39
    • 0035031472 scopus 로고    scopus 로고
    • In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery
    • The authors provided excellent comparisons and precautions for different high-throughput metabolic screening assays
    • Masimirembwa C.M., Thompson R., Andersson T.B. In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery. Comb. Chem. High Throughput Screen. 4:2001;245-263 The authors provided excellent comparisons and precautions for different high-throughput metabolic screening assays.
    • (2001) Comb. Chem. High Throughput Screen , vol.4 , pp. 245-263
    • Masimirembwa, C.M.1    Thompson, R.2    Andersson, T.B.3
  • 40
    • 0035313896 scopus 로고    scopus 로고
    • Screening for human ADME/Tox drug properties in drug discovery
    • Li A.P. Screening for human ADME/Tox drug properties in drug discovery. Drug Disc. Today. 6:2001;357-366.
    • (2001) Drug Disc. Today , vol.6 , pp. 357-366
    • Li, A.P.1
  • 41
    • 0036112196 scopus 로고    scopus 로고
    • Application of parallel liquid chromatography/mass spectrometry for high throughput microsomal stability screening of compound libraries
    • Xu R., Nemes C., Jenkins K.M., Rourick R.A., Kassel D.B., Liu C.Z.C. Application of parallel liquid chromatography/mass spectrometry for high throughput microsomal stability screening of compound libraries. J. Am. Soc. Mass. Spec. 13:2002;155-165.
    • (2002) J. Am. Soc. Mass. Spec. , vol.13 , pp. 155-165
    • Xu, R.1    Nemes, C.2    Jenkins, K.M.3    Rourick, R.A.4    Kassel, D.B.5    Liu, C.Z.C.6
  • 42
    • 0035298741 scopus 로고    scopus 로고
    • A high-capacity LC/MS system for the bioanalysis of samples generated from plate-based metabolic screening
    • An innovative approach for increasing sensitivity and selectivity in high-throughput assays by using LC/MS/MS and unique automation
    • Janiszewski J.S., Rogers K.J., Whalen K.M., Cole M.J., Liston T.E., Duchoslav E., Fouda H.G. A high-capacity LC/MS system for the bioanalysis of samples generated from plate-based metabolic screening. Anal. Chem. 73:2001;1495-1501 An innovative approach for increasing sensitivity and selectivity in high-throughput assays by using LC/MS/MS and unique automation.
    • (2001) Anal. Chem. , vol.73 , pp. 1495-1501
    • Janiszewski, J.S.1    Rogers, K.J.2    Whalen, K.M.3    Cole, M.J.4    Liston, T.E.5    Duchoslav, E.6    Fouda, H.G.7
  • 43
    • 0033800945 scopus 로고    scopus 로고
    • Rapid assessment of drug metabolism in the drug discovery process
    • Bertrand M., Jackson P., Walther B. Rapid assessment of drug metabolism in the drug discovery process. Eur. J. Pharm. Sci. 11(Suppl 2):2000;S61-S72.
    • (2000) Eur. J. Pharm. Sci. , vol.11 , Issue.SUPPL. 2
    • Bertrand, M.1    Jackson, P.2    Walther, B.3
  • 44
    • 0037175444 scopus 로고    scopus 로고
    • Semi-automated determination of plasma stability of drug discovery compounds using liquid chromatography-tandem mass spectrometry
    • Wang G., Hsieh Y., Lau Y.Y., Cheng K.-C., Ng K., Korfmacher W.A., White R.E. Semi-automated determination of plasma stability of drug discovery compounds using liquid chromatography-tandem mass spectrometry. J. Chromatogr. B. 780:2002;451-457.
    • (2002) J. Chromatogr. B , vol.780 , pp. 451-457
    • Wang, G.1    Hsieh, Y.2    Lau, Y.Y.3    Cheng, K.-C.4    Ng, K.5    Korfmacher, W.A.6    White, R.E.7
  • 46
    • 0037212558 scopus 로고    scopus 로고
    • High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry
    • Testino S.A. Jr., Patonay G. High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal. 30:2003;1459-1467.
    • (2003) J. Pharm. Biomed. Anal. , vol.30 , pp. 1459-1467
    • Testino S.A., Jr.1    Patonay, G.2
  • 47
    • 0032970480 scopus 로고    scopus 로고
    • Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: Assessment of human CYP inhibition potential
    • Moody G.C., Griffin S.J., Mather A.N., McGinnity D.F., Riley R.J. Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential. Xenobiotica. 29:1999;53-75.
    • (1999) Xenobiotica , vol.29 , pp. 53-75
    • Moody, G.C.1    Griffin, S.J.2    Mather, A.N.3    McGinnity, D.F.4    Riley, R.J.5
  • 49
    • 0035039894 scopus 로고    scopus 로고
    • Inhibition of CYP3A4 in a rapid microtiter plate assay using recombinant enzyme and in human liver microsomes using conventional substrates
    • Nomeir A.A., Ruegg C., Shoemaker M., Favreau L.V., Palamanda J.R., Silber P., Lin C.C. Inhibition of CYP3A4 in a rapid microtiter plate assay using recombinant enzyme and in human liver microsomes using conventional substrates. Drug Metab. Disp. 29:2001;748-753.
    • (2001) Drug Metab. Disp. , vol.29 , pp. 748-753
    • Nomeir, A.A.1    Ruegg, C.2    Shoemaker, M.3    Favreau, L.V.4    Palamanda, J.R.5    Silber, P.6    Lin, C.C.7
  • 51
    • 0037204548 scopus 로고    scopus 로고
    • Computational methods for the prediction of ADME and toxicity
    • The entire issue (page 253-451) covers in silico methods for ADME/TOX predictions by a group of highly respected scientists
    • Clark D.E. Computational methods for the prediction of ADME and toxicity. Adv. Drug Deliv. Rev. 54:2002;253-254 The entire issue (page 253-451) covers in silico methods for ADME/TOX predictions by a group of highly respected scientists.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 253-254
    • Clark, D.E.1
  • 53
    • 0037153202 scopus 로고    scopus 로고
    • Structure-activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)- 5-{2-[(3-substituted)-1-azetidinyl]ethyl}-2-piperidones. 1. Selective antagonists of the neurokinin-2 receptor
    • MacKenzie A.R., Marchington A.P., Middleton D.S., Newman S.D., Jones B.C. Structure-activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)- 5-{2-[(3-substituted)-1-azetidinyl]ethyl}-2-piperidones. 1. Selective antagonists of the neurokinin-2 receptor. J. Med. Chem. 45:2002;5365-5377.
    • (2002) J. Med. Chem. , vol.45 , pp. 5365-5377
    • MacKenzie, A.R.1    Marchington, A.P.2    Middleton, D.S.3    Newman, S.D.4    Jones, B.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.