Myocardial Glucose Clearance by Aspalathin Treatment in Young, Mature, and Obese Insulin-Resistant Rats

Planta Medica

Volumn 84, Issue 2, 2018, Pages 75-82

  Smit, Sybrand Engelbrecht ^a   Johnson, Rabia ^a,b   Van Vuuren, Mignon Alberta ^a   Huisamen, Barbara ^a,b  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

^b SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

Author keywords

aspalathin; cardiomyocytes; hyperglycemia; insulin resistance; obesity; rooibos

Indexed keywords

ANTIDIABETIC AGENT; ASPALATHIN; COLLAGENASE; DEOXYGLUCOSE; GLUCOSE; INSULIN; PHENOL DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROPIDIUM IODIDE; TRYPAN BLUE; UNCLASSIFIED DRUG; CHALCONE DERIVATIVE;

ADULT; AGE; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CALORIC INTAKE; CARDIAC MUSCLE CELL; CELL ISOLATION; CELL VIABILITY; CONTROLLED STUDY; DIET RESTRICTION; DRUG MECHANISM; DRUG POTENTIATION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HEART MUSCLE METABOLISM; HEART VENTRICLE; HIGH CALORIC DIET; HORMONE ACTION; IN VITRO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAPERITONEAL FAT; JUVENILE ANIMAL; LIPID DIET; MALE; NONHUMAN; OBESITY; PROPIDIUM IODIDE ASSAY; RAT; TRYPAN BLUE ASSAY; WEIGHT GAIN; WISTAR RAT; ADIPOSE TISSUE; ANIMAL; ASPALATHUS; CARDIAC MUSCLE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; METABOLISM; SYNTHESIS;

ADIPOSE TISSUE; ANIMALS; ASPALATHUS; BLOOD GLUCOSE; CHALCONES; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; MALE; MYOCARDIUM; MYOCYTES, CARDIAC; OBESITY; RATS, WISTAR;

EID: 85027019631     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0043-117415     Document Type: Article

References (29)

1. World Health Organization Cardiovascular Diseases. Global Initiative. World Health Organization. Available at http://www.who.int/cardiovascular-diseases/en/ Accessed February 5, 2017
2. DeFronzo R. A. Pathogenesis of type 2 diabetes mellitus. Med Clin North Am: 2004; 88 787 835
3. Misbin R. I. Evaluating the safety of diabetes drugs: perspective of a food and drug administration insider. Diabetes Care: 2005; 28 2573 2576
4. Abdulreda M. H. Rodriguez-Diaz R. Caicedo A. Berggren P. O. Liraglutide compromises pancreatic β cell function in a humanized mouse model. Cell Metab: 2016; 23 541 546
5. Boussageon R. Bejan-Angoulvant T. Saadatian-Elahi M. Lafont S. Bergeonneau C. Kassai B. Erpeldinger S. Wright J. M. Gueyffier F. Cornu C. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ: 2011; 343 d4169
6. Van der Merwe J. D. Joubert E. Richards E. S. Manley M. Snijman P. W. Marnewick J. L. Gelderblom W. CA. A comparative study on the antimutagenic properties of aqueous extracts of Aspalathus linearis (rooibos), different Cyclopia spp. (honeybush) and Camellia sinensis teas. Mutat Res: 2006; 611 42 53
7. Marnewick J. L. Rautenbach F. Venter I. Neethling H. Blackhurst D. M. Wolmarans P. Macharia M. Effects of rooibos (Aspalathus linearis) on oxidative stress and biochemical parameters in adults at risk for cardiovascular disease. J Ethnopharmacol: 2011; 133 46 52
8. Mazibuko S. E. Muller C. JF. Joubert E. De Beer D. Johnson R. Opoku A. R. Louw J. Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (aspalathus linearis). Phytomedicine: 2013; 20 813 819
9. Kawano A. Nakamura H. Hata S. Minakawa M. Miura Y. Yagasaki K. Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice. Phytomedicine: 2009; 16 437 443
10. Muller C. JF. Joubert E. de Beer D. Sanderson M. Malherbe C. J. Fey S. J. Louw J. Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential. Phytomedicine: 2012; 20 32 39
11. Son M. J. Minakawa M. Miura Y. Yagasaki K. Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice. Eur J Nutr: 2013; 52 1607 1619
12. Huisamen B. George C. Dietrich D. Genade S. Cardioprotective and anti-hypertensive effects of Prosopis glandulosa in rat models of pre-diabetes: cardiovascular topics. Cardiovasc J Afr: 2013; 24 10 16
13. Blüher M. Adipose tissue dysfunction contributes to obesity related metabolic diseases. Best Pract Res Clin Endocrinol Metab: 2013; 27 163 177
14. Grundy S. M. Pre-diabetes, metabolic syndrome, and cardiovascular risk. J Am Coll Cardiol: 2012; 59 635 643
15. Norris J. M. Rich S. S. Genetics of glucose homeostasis: implications for insulin resistance and metabolic syndrome. Arterioscler Thromb Vasc Biol: 2012; 32 2091 2096
16. Huisamen B. Genis A. Marais E. Lochner A. Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, pre-diabetic rats. Cardiovasc Drugs Ther: 2011; 25 13 20
17. Yadav A. Kataria M. A. Saini V. Yadav A. Role of leptin and adiponectin in insulin resistance. Clin Chim Acta: 2013; 417 80 84
18. Ding L. Song A. Dai M. Xu M. Sun W. Xu B. Sun J. Wang T. Xu Y. Lu J. Wang W. Bi Y. Ning G. Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population. J Lipid Res: 2015; 56 920 926
19. Boden G. Shulman G. I. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest: 2002; 32 14 23
20. Boden G. Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes: 2011; 18 139 143
21. Boden G. Free fatty acids, insulin resistance, and type 2 diabetes mellitus. Proc Assoc Am Physicians: 1999; 111 241 248
22. Montessuit C. Lerch R. Regulation and dysregulation of glucose transport in cardiomyocytes. Biochim Biophys Acta: 2013; 1833 848 856
23. Berenguer M. Zhang J. Bruce M. C. Martinez L. Gonzalez T. Gurtovenko A. A. Xu T. Le Marchand-Brustel Y. Govers R. Dimethyl sulfoxide enhances GLUT4 translocation through a reduction in GLUT4 endocytosis in insulin-stimulated 3T3-L1 adipocytes. Biochimie: 2011; 93 697 709
24. Frosig C. Jensen T. E. Jeppesen J. Pehmoller C. Treebak J. T. Maarbjerg S. J. Kristensen J. M. Sylow L. Alsted T. J. Schjerling P. Kiens B. Wojtaszewski J. F. AMPK and insulin action - responses to ageing and high fat diet. PLoS One: 2013; 8 e62338
25. Fu Z. Gilbert E. R. Liu D. Regulation of insulin synthesis and secretion and pancreatic beta-cell dysfunction in diabetes. Curr Diabetes Rev: 2013; 9 25 53
26. Yeh J. I. Gulve E. A. Rameh L. Birnbaum M. J. The effects of wortmannin on rat skeletal muscle. Dissociation of signaling pathways for insulin- and contraction-activated hexose transport. J Biol Chem: 1995; 270 2107 2111
27. Purintrapiban J. Ratanachaiyavong S. The effects of insulin and metformin on glucose uptake in L8 myotubes. Sci Asia: 2003; 29 341 346
28. Fischer Y. Rose H. Kammermeier H. Highly insulin-responsive isolated rat heart muscle cells yielded by a modified isolation method. Life Sci: 1991; 49 1679 1688
29. Lowry H. O. Rosebrough J. N. Farr A. L. Randall J. R. Protein measurement with the folin phenol reagent. J Biol Chem: 1951; 193 265 275