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Volumn 4, Issue MAY, 2013, Pages

Mechanisms of obesity-induced inflammation and insulin resistance: Insights into the emerging role of nutritional strategies

Author keywords

Immune cell infiltration; Inflammation; Insulin resistance; Nutrient sensing; Obesity; PUFA

Indexed keywords

ADIPONECTIN; INFLAMMASOME; INTERFERON; INTERLEUKIN 10; MACROPHAGE MIGRATION INHIBITION FACTOR; PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84884193931     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2013.00052     Document Type: Review
Times cited : (402)

References (323)
  • 1
    • 17444417085 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Adams, L. A., Angulo, P., and Lindor, K. D. (2005). Nonalcoholic fatty liver disease. CMAJ 172, 899-905.
    • (2005) CMAJ , vol.172 , pp. 899-905
    • Adams, L.A.1    Angulo, P.2    Lindor, K.D.3
  • 2
    • 79952291528 scopus 로고    scopus 로고
    • Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases
    • Akdis, M., Burgler, S., Crameri, R., Eiwegger, T., Fujita, H., Gomez, E., et al. (2011). Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases. J. Allergy Clin. Immunol. 127, 701-721.
    • (2011) J. Allergy Clin. Immunol. , vol.127 , pp. 701-721
    • Akdis, M.1    Burgler, S.2    Crameri, R.3    Eiwegger, T.4    Fujita, H.5    Gomez, E.6
  • 3
    • 84867966112 scopus 로고    scopus 로고
    • Does inflammation determine whether obesity is metabolically healthy or unhealthy? The aging perspective
    • Alam, I., Ng, T. P., and Larbi, A. (2012). Does inflammation determine whether obesity is metabolically healthy or unhealthy? The aging perspective. Mediators Inflamm. 2012, 456-456.
    • (2012) Mediators Inflamm. , vol.2012 , pp. 456-456
    • Alam, I.1    Ng, T.P.2    Larbi, A.3
  • 6
    • 33747061905 scopus 로고    scopus 로고
    • Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin
    • Aso, Y., Yamamoto, R., Wakabayashi, S., Uchida, T., Takayanagi, K., Takebayashi, K., et al. (2006). Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin. Diabetes 55, 1954-1960.
    • (2006) Diabetes , vol.55 , pp. 1954-1960
    • Aso, Y.1    Yamamoto, R.2    Wakabayashi, S.3    Uchida, T.4    Takayanagi, K.5    Takebayashi, K.6
  • 7
    • 38449097890 scopus 로고    scopus 로고
    • The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation
    • Atsumi, T., Cho, Y. R., Leng, L., McDonald, C., Yu, T., Danton, C., et al. (2007). The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation. J. Immunol. 179, 5399-5406.
    • (2007) J. Immunol. , vol.179 , pp. 5399-5406
    • Atsumi, T.1    Cho, Y.R.2    Leng, L.3    McDonald, C.4    Yu, T.5    Danton, C.6
  • 8
    • 34548287996 scopus 로고    scopus 로고
    • Oxidative stress: a dead end or a laboratory hypothesis? Biochem
    • Azzi, A. (2007). Oxidative stress: a dead end or a laboratory hypothesis? Biochem. Biophys. Res. Commun. 362, 230-232.
    • (2007) Biophys. Res. Commun. , vol.362 , pp. 230-232
    • Azzi, A.1
  • 9
    • 77950493668 scopus 로고    scopus 로고
    • An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach
    • Bakker, G. C., Van Erk, M. J., Pellis, L., Wopereis, S., Rubingh, C. M., Cnubben, N. H., et al. (2010). An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. Am. J. Clin. Nutr. 91, 1044-1059.
    • (2010) Am. J. Clin. Nutr. , vol.91 , pp. 1044-1059
    • Bakker, G.C.1    Van Erk, M.J.2    Pellis, L.3    Wopereis, S.4    Rubingh, C.M.5    Cnubben, N.H.6
  • 11
    • 0036162165 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor
    • Baugh, J. A., and Bucala, R. (2002). Macrophage migration inhibitory factor. Crit. Care Med. 30, S27-S35.
    • (2002) Crit. Care Med. , vol.30
    • Baugh, J.A.1    Bucala, R.2
  • 13
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg, A. H., Combs, T. P., Du, X., Brownlee, M., and Scherer, P. E. (2001). The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7, 947- 953.
    • (2001) Nat. Med. , vol.7
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 14
    • 34249066942 scopus 로고    scopus 로고
    • MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
    • Bernhagen, J., Krohn, R., Lue, H., Gregory, J. L., Zernecke, A., Koenen, R. R., et al. (2007). MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat. Med. 13, 587-596.
    • (2007) Nat. Med. , vol.13 , pp. 587-596
    • Bernhagen, J.1    Krohn, R.2    Lue, H.3    Gregory, J.L.4    Zernecke, A.5    Koenen, R.R.6
  • 15
    • 0034183503 scopus 로고    scopus 로고
    • Free fatty acids are involved in the inverse relationship between hormone-sensitive lipase (HSL) activity and expression in adipose tissue after high-fat feeding or beta3-adrenergic stimulation
    • Berraondo, B., and Martínez, J. A. (2000). Free fatty acids are involved in the inverse relationship between hormone-sensitive lipase (HSL) activity and expression in adipose tissue after high-fat feeding or beta3-adrenergic stimulation. Obes. Res. 8, 255-261.
    • (2000) Obes. Res. , vol.8 , pp. 255-261
    • Berraondo, B.1    Martínez, J.A.2
  • 16
    • 84865461206 scopus 로고    scopus 로고
    • Identification of adipose tissue dendritic cells correlated with obesityassociated insulin-resistance and inducing Th17 responses in mice and patients
    • Bertola, A., Ciucci, T., Rousseau, D., Bourlier, V., Duffaut, C., Bonnafous, S., et al. (2012). Identification of adipose tissue dendritic cells correlated with obesityassociated insulin-resistance and inducing Th17 responses in mice and patients. Diabetes 61, 2238-2247.
    • (2012) Diabetes , vol.61 , pp. 2238-2247
    • Bertola, A.1    Ciucci, T.2    Rousseau, D.3    Bourlier, V.4    Duffaut, C.5    Bonnafous, S.6
  • 17
    • 79951814996 scopus 로고    scopus 로고
    • GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms
    • Bhattacharya, P., Gopisetty, A., Ganesh, B. B., Sheng, J. R., and Prabhakar, B. S. (2011). GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms. J. Leukoc. Biol. 89, 235-249.
    • (2011) J. Leukoc. Biol. , vol.89 , pp. 235-249
    • Bhattacharya, P.1    Gopisetty, A.2    Ganesh, B.B.3    Sheng, J.R.4    Prabhakar, B.S.5
  • 18
    • 0025299388 scopus 로고
    • "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes
    • Bjorntorp, P. (1990). "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 10, 493-496.
    • (1990) Arteriosclerosis , vol.10 , pp. 493-496
    • Bjorntorp, P.1
  • 20
    • 84873029099 scopus 로고    scopus 로고
    • Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance
    • Boon, J., Hoy, A. J., Stark, R., Brown, R. D., Meex, R. C., Henstridge, D. C., et al. (2013). Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes 62, 401-410.
    • (2013) Diabetes , vol.62 , pp. 401-410
    • Boon, J.1    Hoy, A.J.2    Stark, R.3    Brown, R.D.4    Meex, R.C.5    Henstridge, D.C.6
  • 21
    • 84871490319 scopus 로고    scopus 로고
    • Examining the safety of PPAR agonists - current trends and future prospects
    • Bortolini, M., Wright, M. B., Bopst, M., and Balas, B. (2013). Examining the safety of PPAR agonists - current trends and future prospects. Expert Opin. Drug Saf. 12, 65-79.
    • (2013) Expert Opin. Drug Saf. , vol.12 , pp. 65-79
    • Bortolini, M.1    Wright, M.B.2    Bopst, M.3    Balas, B.4
  • 22
    • 74049139572 scopus 로고    scopus 로고
    • Postprandial dietary lipid - specific effects on human peripheral blood mononuclear cell gene expression profiles 1-3
    • Bouwens, M., Bromhaar, M. G., Jansen, J., Mu, M., and Afman, L. A. (2010). Postprandial dietary lipid - specific effects on human peripheral blood mononuclear cell gene expression profiles 1-3. Am. J. Clin. Nutr. 91, 208-217.
    • (2010) Am. J. Clin. Nutr. , vol.91 , pp. 208-217
    • Bouwens, M.1    Bromhaar, M.G.2    Jansen, J.3    Mu, M.4    Afman, L.A.5
  • 23
    • 42949150111 scopus 로고    scopus 로고
    • Dietary fatty acids differentially regulate production of TNF-alpha and IL-10 by murine 3T3-L1 adipocytes
    • Bradley, R. L., Fisher, F. F. M., and Maratos-Flier, E. (2008). Dietary fatty acids differentially regulate production of TNF-alpha and IL-10 by murine 3T3-L1 adipocytes. Obesity (Silver Spring) 16, 938-944.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 938-944
    • Bradley, R.L.1    Fisher, F.F.M.2    Maratos-Flier, E.3
  • 24
    • 68149169760 scopus 로고    scopus 로고
    • Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease
    • Brereton, C. F., Sutton, C. E., Lalor, S. J., Lavelle, E. C., and Mills, K. H. G. (2009). Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease. J. Immunol. 183, 1715-1723.
    • (2009) J. Immunol. , vol.183 , pp. 1715-1723
    • Brereton, C.F.1    Sutton, C.E.2    Lalor, S.J.3    Lavelle, E.C.4    Mills, K.H.G.5
  • 25
    • 2542448243 scopus 로고    scopus 로고
    • CD1: antigen presentation and T cell function
    • Brigl, M., and Brenner, M. B. (2004). CD1: antigen presentation and T cell function. Annu. Rev. Immunol. 22, 817-890.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 817-890
    • Brigl, M.1    Brenner, M.B.2
  • 26
    • 0035052940 scopus 로고    scopus 로고
    • What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? J
    • Brochu, M., Tchernof, A., Dionne, I. J., Sites, C. K., Eltabbakh, G. H., Sims, E. A., et al. (2001). What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? J. Clin. Endocrinol. Metab. 86, 1020-1025.
    • (2001) Clin. Endocrinol. Metab. , vol.86 , pp. 1020-1025
    • Brochu, M.1    Tchernof, A.2    Dionne, I.J.3    Sites, C.K.4    Eltabbakh, G.H.5    Sims, E.A.6
  • 27
    • 38649116056 scopus 로고    scopus 로고
    • Selective versus total insulin resistance: a pathogenic paradox
    • Brown, M. S., and Goldstein, J. L. (2008). Selective versus total insulin resistance: a pathogenic paradox. Cell Metab. 7, 95-96.
    • (2008) Cell Metab. , vol.7 , pp. 95-96
    • Brown, M.S.1    Goldstein, J.L.2
  • 28
    • 80053597754 scopus 로고    scopus 로고
    • MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia
    • Bruning, U., Cerone, L., Neufeld, Z., Fitzpatrick, S. F., Cheong, A., Scholz, C. C., et al. (2011). MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol. Cell. Biol. 31, 4087-4096.
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 4087-4096
    • Bruning, U.1    Cerone, L.2    Neufeld, Z.3    Fitzpatrick, S.F.4    Cheong, A.5    Scholz, C.C.6
  • 30
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., et al. (2005). Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat. Immunol. 11, 183-190.
    • (2005) Nat. Immunol. , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6
  • 31
    • 0028305693 scopus 로고
    • The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor
    • Calandra, T., Bernhagen, J., Mitchell, R. A., and Bucala, R. (1994). The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. J. Exp. Med. 179, 1895-1902.
    • (1994) J. Exp. Med. , vol.179 , pp. 1895-1902
    • Calandra, T.1    Bernhagen, J.2    Mitchell, R.A.3    Bucala, R.4
  • 32
    • 0142259734 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor: a regulator of innate immunity
    • Calandra, T., and Roger, T. (2003). Macrophage migration inhibitory factor: a regulator of innate immunity. Nat. Rev. Immunol. 3, 791-800.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 791-800
    • Calandra, T.1    Roger, T.2
  • 33
    • 82955170624 scopus 로고    scopus 로고
    • Dietary factors and low-grade inflammation in relation to overweight and obesity
    • Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., et al. (2011). Dietary factors and low-grade inflammation in relation to overweight and obesity. Br. J. Nutr. 106(Suppl.), S5-S78.
    • (2011) Br. J. Nutr. , vol.106 , Issue.SUPPL.
    • Calder, P.C.1    Ahluwalia, N.2    Brouns, F.3    Buetler, T.4    Clement, K.5    Cunningham, K.6
  • 34
    • 23644450775 scopus 로고    scopus 로고
    • Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss
    • Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., et al. (2005). Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 54, 2277-2286.
    • (2005) Diabetes , vol.54 , pp. 2277-2286
    • Cancello, R.1    Henegar, C.2    Viguerie, N.3    Taleb, S.4    Poitou, C.5    Rouault, C.6
  • 35
    • 84866141957 scopus 로고    scopus 로고
    • Immunological functions of leptin and adiponectin
    • Carbone, F., La Rocca, C., and Matarese, G. (2012). Immunological functions of leptin and adiponectin. Biochimie 94, 2082-2088.
    • (2012) Biochimie , vol.94 , pp. 2082-2088
    • Carbone, F.1    La Rocca, C.2    Matarese, G.3
  • 37
    • 84855681355 scopus 로고    scopus 로고
    • Adipose tissue stem cells meet preadipocyte commitment: going back to the future
    • Cawthorn, W. P., Scheller, E. L., and MacDougald, O. A. (2012). Adipose tissue stem cells meet preadipocyte commitment: going back to the future. J. Lipid Res. 53, 227-246.
    • (2012) J. Lipid Res. , vol.53 , pp. 227-246
    • Cawthorn, W.P.1    Scheller, E.L.2    MacDougald, O.A.3
  • 38
    • 0029047933 scopus 로고
    • Inhibition of tumour necrosis factor by curcumin, a phytochemical
    • Chan, M. M. (1995). Inhibition of tumour necrosis factor by curcumin, a phytochemical. Biochem. Pharmacol. 49, 1551-1556.
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 1551-1556
    • Chan, M.M.1
  • 39
    • 0038532298 scopus 로고    scopus 로고
    • A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
    • Chavez, J. A., Knotts, T. A., Wang, L. P., Li, G., Dobrowsky, R. T., Florant, G. L., et al. (2003). A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J. Biol. Chem. 278, 10297-10303.
    • (2003) J. Biol. Chem. , vol.278 , pp. 10297-10303
    • Chavez, J.A.1    Knotts, T.A.2    Wang, L.P.3    Li, G.4    Dobrowsky, R.T.5    Florant, G.L.6
  • 40
    • 0037204948 scopus 로고    scopus 로고
    • TNF-R1 signaling: a beautiful pathway
    • Chen, G., and Goeddel, D. V. (2002). TNF-R1 signaling: a beautiful pathway. Science 296, 1634-1635.
    • (2002) Science , vol.296 , pp. 1634-1635
    • Chen, G.1    Goeddel, D.V.2
  • 41
    • 78651290317 scopus 로고    scopus 로고
    • Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-alpha - mediated inflammation and insulin resistance in primary human adipocytes 1 - 3
    • Chuang, C., Martinez, K., Xie, G., Kennedy, A., Bumrungpert, A., Overman, A., et al. (2010). Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-alpha - mediated inflammation and insulin resistance in primary human adipocytes 1 - 3. Am. J. Clin. Nutr. 92, 1511-1521.
    • (2010) Am. J. Clin. Nutr. , vol.92 , pp. 1511-1521
    • Chuang, C.1    Martinez, K.2    Xie, G.3    Kennedy, A.4    Bumrungpert, A.5    Overman, A.6
  • 42
    • 33751235259 scopus 로고    scopus 로고
    • Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes
    • Chung, S., Lapoint, K., Martinez, K., Kennedy, A., Boysen Sandberg, M., and McIntosh, M. K. (2006). Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology 147, 5340-5351.
    • (2006) Endocrinology , vol.147 , pp. 5340-5351
    • Chung, S.1    Lapoint, K.2    Martinez, K.3    Kennedy, A.4    Boysen Sandberg, M.5    McIntosh, M.K.6
  • 44
    • 0033595120 scopus 로고    scopus 로고
    • Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes
    • Cline, G. W., Petersen, K. F., Krssak, M., Shen, J., Hundal, R. S., Trajanoski, Z., et al. (1999). Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N. Engl. J. Med. 341, 240-246.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 240-246
    • Cline, G.W.1    Petersen, K.F.2    Krssak, M.3    Shen, J.4    Hundal, R.S.5    Trajanoski, Z.6
  • 45
    • 80755159548 scopus 로고    scopus 로고
    • Oxidant mechanisms in childhood obesity: the link between inflammation and oxidative stress
    • Codoñer-Franch, P., Valls-Bellés, V., Arilla-Codoñer, A.,and Alonso-Iglesias, E. (2011). Oxidant mechanisms in childhood obesity: the link between inflammation and oxidative stress. Transl. Res. 158, 369-384.
    • (2011) Transl. Res. , vol.158 , pp. 369-384
    • Codoñer-Franch, P.1    Valls-Bellés, V.2    Arilla-Codoñer, A.3    Alonso-Iglesias, E.4
  • 48
    • 44449096726 scopus 로고    scopus 로고
    • IL-10: the master regulator of immunity to infection
    • Couper, K. N., Blount, D. G., and Riley, E. M. (2008). IL-10: the master regulator of immunity to infection. J. Immunol. 180, 5771-5777.
    • (2008) J. Immunol. , vol.180 , pp. 5771-5777
    • Couper, K.N.1    Blount, D.G.2    Riley, E.M.3
  • 49
    • 77954143695 scopus 로고    scopus 로고
    • Innate IL-17-producing cells: the sentinels of the immune system
    • Cua, D. J., and Tato, C. M. (2010). Innate IL-17-producing cells: the sentinels of the immune system. Nat. Rev. Immunol. 10, 479-489.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 479-489
    • Cua, D.J.1    Tato, C.M.2
  • 50
    • 2342537773 scopus 로고    scopus 로고
    • From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes
    • Curat, C. A., Miranville, A., Sengene, C., Diehl, M., Tonus, C., Busse, R., et al. (2004). From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 53, 1285-1292.
    • (2004) Diabetes , vol.53 , pp. 1285-1292
    • Curat, C.A.1    Miranville, A.2    Sengene, C.3    Diehl, M.4    Tonus, C.5    Busse, R.6
  • 51
    • 6344247712 scopus 로고    scopus 로고
    • Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin
    • Dandona, P., Aljada, A., Ghanim, H., Mohanty, P., Tripathy, C., Hofmeyer, D., et al. (2004). Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin. J. Clin. Endocrinol. Metab. 89, 5043-5047.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 5043-5047
    • Dandona, P.1    Aljada, A.2    Ghanim, H.3    Mohanty, P.4    Tripathy, C.5    Hofmeyer, D.6
  • 52
    • 30044438426 scopus 로고    scopus 로고
    • Stressed out about obesity and insulin resistance
    • De Luca, C., and Olefsky, J. M. (2006). Stressed out about obesity and insulin resistance. Nat. Med. 12, 41-42.
    • (2006) Nat. Med. , vol.12 , pp. 41-42
    • De Luca, C.1    Olefsky, J.M.2
  • 53
    • 67650744652 scopus 로고    scopus 로고
    • Attenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet
    • De Roos, B., Rungapamestry, V., Ross, K., Rucklidge, G., Reid, M., Duncan, G., et al. (2009). Attenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet. Proteomics 9, 3244-3256.
    • (2009) Proteomics , vol.9 , pp. 3244-3256
    • De Roos, B.1    Rungapamestry, V.2    Ross, K.3    Rucklidge, G.4    Reid, M.5    Duncan, G.6
  • 54
    • 75549085755 scopus 로고    scopus 로고
    • Skeletal muscle insulin resistance is the primary defect in type 2 diabetes
    • DeFronzo, R. A., and Tripathy, D. (2009). Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care 32(Suppl. 2), S157-S163.
    • (2009) Diabetes Care , vol.32 , Issue.SUPPL. 2
    • DeFronzo, R.A.1    Tripathy, D.2
  • 55
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1
    • Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., et al. (1999). Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. J. Biol. Chem. 274, 32048-32054.
    • (1999) J. Biol. Chem. , vol.274 , pp. 32048-32054
    • Delerive, P.1    De Bosscher, K.2    Besnard, S.3    Vanden Berghe, W.4    Peters, J.M.5    Gonzalez, F.J.6
  • 57
    • 79952389800 scopus 로고    scopus 로고
    • Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens
    • DePaolo, R. W., Abadie, V., Tang, F., Fehlner-Peach, H., Hall, J. A., Wang, W., et al. (2011). Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature 471, 220-224.
    • (2011) Nature , vol.471 , pp. 220-224
    • DePaolo, R.W.1    Abadie, V.2    Tang, F.3    Fehlner-Peach, H.4    Hall, J.A.5    Wang, W.6
  • 59
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello, C. A. (2009). Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27, 519-550.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 60
    • 0037295102 scopus 로고    scopus 로고
    • Molecular mechanism of the chemopreventive effect of resveratrol
    • Dong, Z. (2003). Molecular mechanism of the chemopreventive effect of resveratrol. Mutat. Res. 52, 145-150.
    • (2003) Mutat. Res. , vol.52 , pp. 145-150
    • Dong, Z.1
  • 61
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., and Parks, E. J. (2005). Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 115, 1343-1351.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 62
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • Dresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., et al. (1999). Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J. Clin. Invest. 103, 253-259.
    • (1999) J. Clin. Invest. , vol.103 , pp. 253-259
    • Dresner, A.1    Laurent, D.2    Marcucci, M.3    Griffin, M.E.4    Dufour, S.5    Cline, G.W.6
  • 63
    • 60649092297 scopus 로고    scopus 로고
    • Regulation by 1, 25-dihydroxy-vitamin D3 on altered TLRs expression and response to ligands of monocyte from autoimmune diabetes
    • Du, T., Zhou, Z.-G., You, S., Lin, J., Yang, L., Zhou, W.-D., et al. (2009). Regulation by 1, 25-dihydroxy-vitamin D3 on altered TLRs expression and response to ligands of monocyte from autoimmune diabetes. Clin. Chim. Acta 402, 13313-13318.
    • (2009) Clin. Chim. Acta , vol.402 , pp. 13313-13318
    • Du, T.1    Zhou, Z.-G.2    You, S.3    Lin, J.4    Yang, L.5    Zhou, W.-D.6
  • 64
    • 80053003174 scopus 로고    scopus 로고
    • Natural salicylates: foods, functions and disease prevention
    • Duthie, G. G., and Wood, A. D. (2011). Natural salicylates: foods, functions and disease prevention. Food Funct. 2, 515-520.
    • (2011) Food Funct. , vol.2 , pp. 515-520
    • Duthie, G.G.1    Wood, A.D.2
  • 65
    • 0033152796 scopus 로고    scopus 로고
    • Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells
    • Eberl, G., Lees, R., Smiley, S. T., Taniguchi, M., Grusby, M. J., and MacDonald, H. R. (1999). Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells. J. Immunol. 162, 6410-6419.
    • (1999) J. Immunol. , vol.162 , pp. 6410-6419
    • Eberl, G.1    Lees, R.2    Smiley, S.T.3    Taniguchi, M.4    Grusby, M.J.5    MacDonald, H.R.6
  • 66
    • 81255157471 scopus 로고    scopus 로고
    • Interleukin-6 enhances insulin secretion by increasing glucagonlike peptide-1 secretion from L cells and alpha cells
    • Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., et al. (2011). Interleukin-6 enhances insulin secretion by increasing glucagonlike peptide-1 secretion from L cells and alpha cells. Nat. Med. 17, 1481-1489.
    • (2011) Nat. Med. , vol.17 , pp. 1481-1489
    • Ellingsgaard, H.1    Hauselmann, I.2    Schuler, B.3    Habib, A.M.4    Baggio, L.L.5    Meier, D.T.6
  • 67
    • 7044272844 scopus 로고    scopus 로고
    • To be or not to be NKT: natural killer T cells in the liver
    • Exley, M. A., and Koziel, M. J. (2004). To be or not to be NKT: natural killer T cells in the liver. Hepatology 40, 1033-1040.
    • (2004) Hepatology , vol.40 , pp. 1033-1040
    • Exley, M.A.1    Koziel, M.J.2
  • 68
    • 18144408371 scopus 로고    scopus 로고
    • Adipose tissue, adipokines, and inflammation
    • Fantuzzi, G. (2005). Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 115, 911-919.
    • (2005) J. Allergy Clin. Immunol. , vol.115 , pp. 911-919
    • Fantuzzi, G.1
  • 69
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: from steatosis to cirrhosis
    • Farrell, G. C., and Larter, C. Z. (2006). Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43, S99-S112.
    • (2006) Hepatology , vol.43
    • Farrell, G.C.1    Larter, C.Z.2
  • 70
    • 0037617454 scopus 로고    scopus 로고
    • Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes
    • Fasshauer, M., Klein, J., Lossner, U., and Paschke, R. (2003). Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes. Horm. Metab. Res. 35, 147-152.
    • (2003) Horm. Metab. Res. , vol.35 , pp. 147-152
    • Fasshauer, M.1    Klein, J.2    Lossner, U.3    Paschke, R.4
  • 71
    • 77949270779 scopus 로고    scopus 로고
    • Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NFkappaB in macrophages
    • Feng, D., Ling, W.-H., and Duan, R.-D. (2010). Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NFkappaB in macrophages. Inflamm. Res. 59, 115-121.
    • (2010) Inflamm. Res. , vol.59 , pp. 115-121
    • Feng, D.1    Ling, W.-H.2    Duan, R.-D.3
  • 72
    • 77749254629 scopus 로고    scopus 로고
    • Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance
    • Ferguson, J. F., Phillips, C. M., Tierney, A. C., Perez-Martinez, P., Defoort, C., Helal, O., et al. (2010). Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Am. J. Clin. Nutr. 91, 794-801.
    • (2010) Am. J. Clin. Nutr. , vol.91 , pp. 794-801
    • Ferguson, J.F.1    Phillips, C.M.2    Tierney, A.C.3    Perez-Martinez, P.4    Defoort, C.5    Helal, O.6
  • 73
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., et al. (2009). Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15, 930-939.
    • (2009) Nat. Med. , vol.15 , pp. 930-939
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3    Naaz, A.4    Wong, J.5    Nayer, A.6
  • 74
    • 79551501873 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status
    • Figueras, M., Olivan, M., Busquets, S., López-Soriano, F. J., and Argilés, J. M. (2011). Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status. Obesity (Silver Spring) 19, 362-369.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 362-369
    • Figueras, M.1    Olivan, M.2    Busquets, S.3    López-Soriano, F.J.4    Argilés, J.M.5
  • 75
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • Finkel, T., and Holbrook, N. J. (2000). Oxidants, oxidative stress and the biology of ageing. Nature 408, 239-247.
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 76
    • 84868286394 scopus 로고    scopus 로고
    • Insights into the role of macrophage migration inhibitory factor in obesity and insulin resistance
    • Finucane, O. M., Reynolds, C. M., McGillicuddy, F. C., and Roche, H. M. (2012). Insights into the role of macrophage migration inhibitory factor in obesity and insulin resistance. Proc. Nutr. Soc. 71, 622-633.
    • (2012) Proc. Nutr. Soc. , vol.71 , pp. 622-633
    • Finucane, O.M.1    Reynolds, C.M.2    McGillicuddy, F.C.3    Roche, H.M.4
  • 78
    • 80054122062 scopus 로고    scopus 로고
    • Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids
    • Flachs, P., Rühl, R., Hensler, M., Janovska, P., Zouhar, P., Kus, V., et al. (2011). Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. Diabetologia 54, 2626-2638.
    • (2011) Diabetologia , vol.54 , pp. 2626-2638
    • Flachs, P.1    Rühl, R.2    Hensler, M.3    Janovska, P.4    Zouhar, P.5    Kus, V.6
  • 79
    • 0037048669 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2000
    • Flegal, K. M., Carroll, M. D., Ogden, C. L., and Johnson, C. L. (2002). Prevalence and trends in obesity among US adults, 1999-2000. JAMA 288, 1723-1727.
    • (2002) JAMA , vol.288 , pp. 1723-1727
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Johnson, C.L.4
  • 80
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferatoractivated receptors alpha and delta
    • Forman, B. M., Chen, J., and Evans, R. M. (1997). Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferatoractivated receptors alpha and delta. Proc. Natl. Acad. Sci. U.S.A. 94, 4312-4317.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 81
    • 33751195101 scopus 로고    scopus 로고
    • AMP-activated protein kinase and the regulation of glucose transport
    • Fujii, N., Jessen, N., and Goodyear, L. J. (2006). AMP-activated protein kinase and the regulation of glucose transport. Am. J. Physiol. Endocrinol. Metab. 291, E867 -E877.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291
    • Fujii, N.1    Jessen, N.2    Goodyear, L.J.3
  • 82
    • 70350560546 scopus 로고    scopus 로고
    • Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice
    • Fujisaka, S., Usui, I., Bukhari, A., Ikutani, M., Oya, T., Kanatani, Y., et al. (2009). Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 58, 2574-2582.
    • (2009) Diabetes , vol.58 , pp. 2574-2582
    • Fujisaka, S.1    Usui, I.2    Bukhari, A.3    Ikutani, M.4    Oya, T.5    Kanatani, Y.6
  • 83
    • 84858110857 scopus 로고    scopus 로고
    • Weight loss/maintenance as an effective tool for controlling type 2 diabetes: novel methodology to sustain weight reduction
    • Gage, D. (2012). Weight loss/maintenance as an effective tool for controlling type 2 diabetes: novel methodology to sustain weight reduction. Diabetes Metab. Res. Rev. 28, 214-218.
    • (2012) Diabetes Metab. Res. Rev. , vol.28 , pp. 214-218
    • Gage, D.1
  • 86
    • 84867740805 scopus 로고    scopus 로고
    • Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
    • Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., et al. (2012). Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat. Immunol. 13, 1118-1128.
    • (2012) Nat. Immunol. , vol.13 , pp. 1118-1128
    • Gautier, E.L.1    Shay, T.2    Miller, J.3    Greter, M.4    Jakubzick, C.5    Ivanov, S.6
  • 88
    • 4644338458 scopus 로고    scopus 로고
    • Circulating mononuclear cells in the obese are in a proinflammatory state
    • Ghanim, H., Aljada, A., Hofmeyer, D., Syed, T., Mohanty, P., and Dandona, P. (2004). Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation 110, 1564-1571.
    • (2004) Circulation , vol.110 , pp. 1564-1571
    • Ghanim, H.1    Aljada, A.2    Hofmeyer, D.3    Syed, T.4    Mohanty, P.5    Dandona, P.6
  • 90
    • 70949102538 scopus 로고    scopus 로고
    • Ceramides: a new player in the inflammation-insulin resistance paradigm?
    • Gill, J. M., and Sattar, N. (2009). Ceramides: a new player in the inflammation-insulin resistance paradigm?. Diabetologia 52, 2475-2477.
    • (2009) Diabetologia , vol.52 , pp. 2475-2477
    • Gill, J.M.1    Sattar, N.2
  • 92
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon, S. (2003). Alternative activation of macrophages. Nat. Rev. Immunol. 3, 23-35.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 23-35
    • Gordon, S.1
  • 94
    • 25144489034 scopus 로고    scopus 로고
    • Metabolic and cellular plasticity in white adipose tissue I: effects of beta3-adrenergic receptor activation
    • Granneman, J. G., Li, P., Zhu, Z., and Lu, Y. (2005). Metabolic and cellular plasticity in white adipose tissue I: effects of beta3-adrenergic receptor activation. Am. J. Physiol. Endocrinol. Metab. 289, E608-E616.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289
    • Granneman, J.G.1    Li, P.2    Zhu, Z.3    Lu, Y.4
  • 95
    • 0031821520 scopus 로고    scopus 로고
    • Understanding adipocyte differentiation
    • Gregoire, F. M., Smas, C. M., and Sul, H. S. (1998). Understanding adipocyte differentiation. Physiol. Rev. 78, 783-809.
    • (1998) Physiol. Rev. , vol.78 , pp. 783-809
    • Gregoire, F.M.1    Smas, C.M.2    Sul, H.S.3
  • 96
    • 14544271905 scopus 로고    scopus 로고
    • Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
    • Gual, P., Le Marchand-Brustel, Y., and Tanti, J. F. (2005). Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87, 99- 109.
    • (2005) Biochimie , vol.87
    • Gual, P.1    Le Marchand-Brustel, Y.2    Tanti, J.F.3
  • 98
    • 25844480615 scopus 로고    scopus 로고
    • Eicosapentaenoic acid, but not oleic acid, stimulates beta-oxidation in adipocytes
    • Guo, W., Xie, W., Lei, T., and Hamilton, J. A. (2005). Eicosapentaenoic acid, but not oleic acid, stimulates beta-oxidation in adipocytes. Lipids 40, 815-821.
    • (2005) Lipids , vol.40 , pp. 815-821
    • Guo, W.1    Xie, W.2    Lei, T.3    Hamilton, J.A.4
  • 99
    • 33646934768 scopus 로고    scopus 로고
    • Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes
    • Gustafson, B., and Smith, U. (2006). Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J. Biol. Chem. 281, 9507-9516.
    • (2006) J. Biol. Chem. , vol.281 , pp. 9507-9516
    • Gustafson, B.1    Smith, U.2
  • 100
    • 68949159760 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue
    • Halberg, N., Khan, T., Trujillo, M. E., Wernstedt-Asterholm, I., Attie, A. D., Sherwani, S., et al. (2009). Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol. Cell 29, 4467-4483.
    • (2009) Mol. Cell , vol.29 , pp. 4467-4483
    • Halberg, N.1    Khan, T.2    Trujillo, M.E.3    Wernstedt-Asterholm, I.4    Attie, A.D.5    Sherwani, S.6
  • 101
    • 0037285962 scopus 로고    scopus 로고
    • Thiazolidinediones (PPARgamma ligands) increase IRS-1, UCP-2 and C/EBPalpha expression, but not transdifferentiation, in L6 muscle cells
    • Hammarstedt, A., and Smith, U. (2003). Thiazolidinediones (PPARgamma ligands) increase IRS-1, UCP-2 and C/EBPalpha expression, but not transdifferentiation, in L6 muscle cells. Diabetologia 46, 48-52.
    • (2003) Diabetologia , vol.46 , pp. 48-52
    • Hammarstedt, A.1    Smith, U.2
  • 102
    • 78649852533 scopus 로고    scopus 로고
    • SIRT1 is regulated by a PPAR{??}-SIRT1 negative feedback loop associated with senescence
    • Han, L., Zhou, R., Niu, J., McNutt, M. A., Wang, P., and Tong, T. (2010). SIRT1 is regulated by a PPAR{??}-SIRT1 negative feedback loop associated with senescence. Nucleic Acids Res. 38, 7458-7471.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 7458-7471
    • Han, L.1    Zhou, R.2    Niu, J.3    McNutt, M.A.4    Wang, P.5    Tong, T.6
  • 103
    • 33745854236 scopus 로고    scopus 로고
    • Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome
    • Hara, K., Horikoshi, M., Yamauchi, T., Yago, H., Miyazaki, O., Ebinuma, H., et al. (2006). Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care 29, 1357-1362.
    • (2006) Diabetes Care , vol.29 , pp. 1357-1362
    • Hara, K.1    Horikoshi, M.2    Yamauchi, T.3    Yago, H.4    Miyazaki, O.5    Ebinuma, H.6
  • 105
    • 80255126307 scopus 로고    scopus 로고
    • Fats, inflammation and insulin resistance: insights to the role of macrophage and Tcell accumulation in adipose tissue
    • Harford, K. A., Reynolds, C. M., McGillicuddy, F. C., and Roche, H. M. (2011). Fats, inflammation and insulin resistance: insights to the role of macrophage and Tcell accumulation in adipose tissue. Proc. Nutr. Soc. 70, 408-417.
    • (2011) Proc. Nutr. Soc. , vol.70 , pp. 408-417
    • Harford, K.A.1    Reynolds, C.M.2    McGillicuddy, F.C.3    Roche, H.M.4
  • 106
    • 63249117466 scopus 로고    scopus 로고
    • Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
    • Haus, J. M., Kashyap, S. R., Kasumov, T., Zhang, R., Kelly, K. R., Defronzo, R. A., et al. (2009). Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes 58, 337-343.
    • (2009) Diabetes , vol.58 , pp. 337-343
    • Haus, J.M.1    Kashyap, S.R.2    Kasumov, T.3    Zhang, R.4    Kelly, K.R.5    Defronzo, R.A.6
  • 107
    • 0030926433 scopus 로고    scopus 로고
    • Role of the glucosamine pathway in fat-induced insulin resistance
    • Hawkins, M., Barzilai, N., Liu, R., Hu, M., Chen, W., and Rossetti, L. (1997). Role of the glucosamine pathway in fat-induced insulin resistance. J. Clin. Invest. 99, 2173-2182.
    • (1997) J. Clin. Invest. , vol.99 , pp. 2173-2182
    • Hawkins, M.1    Barzilai, N.2    Liu, R.3    Hu, M.4    Chen, W.5    Rossetti, L.6
  • 108
    • 29444455533 scopus 로고    scopus 로고
    • Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes
    • He, J., Usui, I., Ishizuka, K., Kanatani, Y., Hiratani, K., Iwata, M., et al. (2006). Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes. Mol. Endocrinol. 20, 114-124.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 114-124
    • He, J.1    Usui, I.2    Ishizuka, K.3    Kanatani, Y.4    Hiratani, K.5    Iwata, M.6
  • 110
    • 80052102312 scopus 로고    scopus 로고
    • Genetic defect in phospholipase C??1 protects mice from obesity by regulating thermogenesis and adipogenesis
    • Hirata, M., Suzuki, M., Ishii, R., Satow, R., Uchida, T., Kitazumi, T., et al. (2011). Genetic defect in phospholipase C??1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes 60, 1926-1937.
    • (2011) Diabetes , vol.60 , pp. 1926-1937
    • Hirata, M.1    Suzuki, M.2    Ishii, R.3    Satow, R.4    Uchida, T.5    Kitazumi, T.6
  • 111
    • 0031959417 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha regulates the gene expression of macrophage migration inhibitory factor through tyrosine kinase-dependent pathway in 3T3-L1 adipocytes
    • Hirokawa, J., Sakaue, S., Furuya, Y., Ishii, J., Hasegawa, A., Tagami, S., et al. (1998). Tumor necrosis factor-alpha regulates the gene expression of macrophage migration inhibitory factor through tyrosine kinase-dependent pathway in 3T3-L1 adipocytes. J. Biochem. 123, 733-739.
    • (1998) J. Biochem. , vol.123 , pp. 733-739
    • Hirokawa, J.1    Sakaue, S.2    Furuya, Y.3    Ishii, J.4    Hasegawa, A.5    Tagami, S.6
  • 112
    • 0031560903 scopus 로고    scopus 로고
    • Identification of macrophage migration inhibitory factor in adipose tissue and its induction by tumor necrosis factor-alpha
    • Hirokawa, J., Sakaue, S., Tagami, S., Kawakami, Y., Sakai, M., Nishi, S., et al. (1997). Identification of macrophage migration inhibitory factor in adipose tissue and its induction by tumor necrosis factor-alpha. Biochem. Biophys. Res. Commun. 235, 94-98.
    • (1997) Biochem. Biophys. Res. Commun. , vol.235 , pp. 94-98
    • Hirokawa, J.1    Sakaue, S.2    Tagami, S.3    Kawakami, Y.4    Sakai, M.5    Nishi, S.6
  • 115
    • 79955487247 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
    • Holland, W. L., Bikman, B. T., Wang, L. P., Yuguang, G., Sargent, K. M., Bulchand, S., et al. (2011). Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J. Clin. Invest. 121, 1858-1870.
    • (2011) J. Clin. Invest. , vol.121 , pp. 1858-1870
    • Holland, W.L.1    Bikman, B.T.2    Wang, L.P.3    Yuguang, G.4    Sargent, K.M.5    Bulchand, S.6
  • 116
    • 0014602357 scopus 로고
    • Regulation of DNA synthesis in fat cells and stromal elements from rat adipose tissue
    • Hollenberg, C. H., and Vost, A. (1969). Regulation of DNA synthesis in fat cells and stromal elements from rat adipose tissue. J. Clin. Invest. 47, 2485-2498.
    • (1969) J. Clin. Invest. , vol.47 , pp. 2485-2498
    • Hollenberg, C.H.1    Vost, A.2
  • 117
    • 70350561703 scopus 로고    scopus 로고
    • Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle
    • Hong, E. G., Ko, H. J., Cho, Y. R., Kim, H. J., Ma, Z., Yu, T. Y., et al. (2009). Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes 58, 2525-2535.
    • (2009) Diabetes , vol.58 , pp. 2525-2535
    • Hong, E.G.1    Ko, H.J.2    Cho, Y.R.3    Kim, H.J.4    Ma, Z.5    Yu, T.Y.6
  • 118
    • 34047119110 scopus 로고    scopus 로고
    • Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
    • Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., et al. (2007). Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56, 901-911.
    • (2007) Diabetes , vol.56 , pp. 901-911
    • Hosogai, N.1    Fukuhara, A.2    Oshima, K.3    Miyata, Y.4    Tanaka, S.5    Segawa, K.6
  • 119
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., and Spiegelman, B. M. (1995). Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 95, 2409-2415.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 121
    • 56749164791 scopus 로고    scopus 로고
    • Nutrient sensing and inflammation in metabolic diseases
    • Hotamisligil, G. S., and Erbay, E. (2008). Nutrient sensing and inflammation in metabolic diseases. Nat. Rev. Immunol. 8, 923-934.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 923-934
    • Hotamisligil, G.S.1    Erbay, E.2
  • 122
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil, G. S., Shargill, N. S., and Spiegelman, B. M. (1993). Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259, 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 123
    • 0032977513 scopus 로고    scopus 로고
    • Age-related adipose tissue mRNA expression of ADD1/SREBP1, PPARgamma, lipoprotein lipase, and GLUT4 glucose transporter in rhesus monkeys
    • Hotta, K., Bodkin, N. L., Gustafson, T. A., Yoshioka, S., Ortmeyer, H. K., and Hansen, B. C. (1999). Age-related adipose tissue mRNA expression of ADD1/SREBP1, PPARgamma, lipoprotein lipase, and GLUT4 glucose transporter in rhesus monkeys. J. Gerontol. A Biol. Sci. Med. Sci. 54, B183-B188.
    • (1999) J. Gerontol. A Biol. Sci. Med. Sci. , vol.54
    • Hotta, K.1    Bodkin, N.L.2    Gustafson, T.A.3    Yoshioka, S.4    Ortmeyer, H.K.5    Hansen, B.C.6
  • 124
    • 77950834598 scopus 로고    scopus 로고
    • Glucocorticoid reamplification within cells intensifies NF-kappaB and MAPK signaling and reinforces inflammation in activated preadipocytes
    • Ishii-Yonemoto, T., Masuzaki, H., Yasue, S., Okada, S., Kozuka, C., Tanaka, T., et al. (2010). Glucocorticoid reamplification within cells intensifies NF-kappaB and MAPK signaling and reinforces inflammation in activated preadipocytes. Am. J. Physiol. Endocrinol. Metab. 298, E930-E940.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298
    • Ishii-Yonemoto, T.1    Masuzaki, H.2    Yasue, S.3    Okada, S.4    Kozuka, C.5    Tanaka, T.6
  • 125
    • 20044387950 scopus 로고    scopus 로고
    • Deficiency of interleukin-1 receptor antagonist deteriorates fatty liver and cholesterol metabolism in hypercholesterolemic mice
    • Isoda, K., Sawada, S., Ayaori, M., Matsuki, T., Horai, R., Kagata, Y., et al. (2005). Deficiency of interleukin-1 receptor antagonist deteriorates fatty liver and cholesterol metabolism in hypercholesterolemic mice. J. Biol. Chem. 280, 7002-7009.
    • (2005) J. Biol. Chem. , vol.280 , pp. 7002-7009
    • Isoda, K.1    Sawada, S.2    Ayaori, M.3    Matsuki, T.4    Horai, R.5    Kagata, Y.6
  • 126
    • 84855661101 scopus 로고    scopus 로고
    • The relationship between patients' serum glucose levels and metabolically active brown adipose tissue detected by PET/CT
    • Jacene, H. A., Cohade, C. C., Zhang, Z., and Wahl, R. L. (2011). The relationship between patients' serum glucose levels and metabolically active brown adipose tissue detected by PET/CT. Mol. Imaging Biol. 13, 1278-1283.
    • (2011) Mol. Imaging Biol. , vol.13 , pp. 1278-1283
    • Jacene, H.A.1    Cohade, C.C.2    Zhang, Z.3    Wahl, R.L.4
  • 127
    • 33845873659 scopus 로고    scopus 로고
    • Interleukin-1beta-induced insulin resistance in adipocytes through downregulation of insulin receptor substrate-1 expression
    • Jager, J., Gremeaux, T., Cormont, M., Le Marchand-Brustel, Y., and Tanti, J. F. (2007). Interleukin-1beta-induced insulin resistance in adipocytes through downregulation of insulin receptor substrate-1 expression. Endocrinology 148, 241-251.
    • (2007) Endocrinology , vol.148 , pp. 241-251
    • Jager, J.1    Gremeaux, T.2    Cormont, M.3    Le Marchand-Brustel, Y.4    Tanti, J.F.5
  • 128
    • 8744309820 scopus 로고    scopus 로고
    • Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state
    • Jellema, A., Plat, J., and Mensink, R. P. (2004). Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state. Eur. J. Clin. Invest. 34, 766-773.
    • (2004) Eur. J. Clin. Invest. , vol.34 , pp. 766-773
    • Jellema, A.1    Plat, J.2    Mensink, R.P.3
  • 129
    • 0942268725 scopus 로고    scopus 로고
    • Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor ?? (PPAR??), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo
    • Jiang, G., Dallas-Yang, Q., Biswas, S., Li, Z., and Zhang, B. B. (2004). Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor ?? (PPAR??), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo. Biochem. J. 15, 339-346.
    • (2004) Biochem. J. , vol.15 , pp. 339-346
    • Jiang, G.1    Dallas-Yang, Q.2    Biswas, S.3    Li, Z.4    Zhang, B.B.5
  • 130
    • 0036326005 scopus 로고    scopus 로고
    • Potentiation of insulin signaling in tissues of Zucker obese rats after acute and longterm treatment with PPARgamma agonists
    • Jiang, G., Dallas-Yang, Q., Li, Z., Szalkowski, D., Liu, F., Shen, X., et al. (2002). Potentiation of insulin signaling in tissues of Zucker obese rats after acute and longterm treatment with PPARgamma agonists. Diabetes 51, 2412-2419.
    • (2002) Diabetes , vol.51 , pp. 2412-2419
    • Jiang, G.1    Dallas-Yang, Q.2    Li, Z.3    Szalkowski, D.4    Liu, F.5    Shen, X.6
  • 131
    • 0034039840 scopus 로고    scopus 로고
    • IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway
    • Joss, A., Akdis, M., Faith, A., Blaser, K., and Akdis, C. A. (2000). IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway. Eur. J. Immunol. 30, 1683-1690.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1683-1690
    • Joss, A.1    Akdis, M.2    Faith, A.3    Blaser, K.4    Akdis, C.A.5
  • 132
    • 12444290860 scopus 로고    scopus 로고
    • Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation
    • Juge-Aubry, C. E., Somm, E., Giusti, V., Pernin, A., Chicheportiche, R., Verdumo, C., et al. (2003). Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation. Diabetes 52, 1104-1110.
    • (2003) Diabetes , vol.52 , pp. 1104-1110
    • Juge-Aubry, C.E.1    Somm, E.2    Giusti, V.3    Pernin, A.4    Chicheportiche, R.5    Verdumo, C.6
  • 133
    • 0024602252 scopus 로고
    • Scanning electron microscopy of very small fat cells and mature fat cells in human obesity
    • Julien, P., Despres, J., and Angel, A. (1989). Scanning electron microscopy of very small fat cells and mature fat cells in human obesity. J. Lipid Res. 30, 293-299.
    • (1989) J. Lipid Res. , vol.30 , pp. 293-299
    • Julien, P.1    Despres, J.2    Angel, A.3
  • 134
    • 36849077566 scopus 로고    scopus 로고
    • Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study
    • Kabir, M., Skurnik, G., Naour, N., Pechtner, V., Meugnier, E., Rome, S., et al. (2007). Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study. Am. J. Clin. Nutr. 86, 1670-1679.
    • (2007) Am. J. Clin. Nutr. , vol.86 , pp. 1670-1679
    • Kabir, M.1    Skurnik, G.2    Naour, N.3    Pechtner, V.4    Meugnier, E.5    Rome, S.6
  • 138
    • 70349131219 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization
    • Kelly, M., Gauthier, M.-S., Saha, A. K., and Ruderman, N. B. (2009). Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization. Diabetes 58, 1953-1960.
    • (2009) Diabetes , vol.58 , pp. 1953-1960
    • Kelly, M.1    Gauthier, M.-S.2    Saha, A.K.3    Ruderman, N.B.4
  • 139
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
    • Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., and Simsolo, R. B. (1995). The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J. Clin. Invest. 95, 2111-2119.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2111-2119
    • Kern, P.A.1    Saghizadeh, M.2    Ong, J.M.3    Bosch, R.J.4    Deem, R.5    Simsolo, R.B.6
  • 140
    • 62849107819 scopus 로고    scopus 로고
    • Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI
    • Khan, T., Muise, E. S., Iyengar, P., Wang, Z. V., Chandalia, M., Abate, N., et al. (2009). Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol. Cell. Biol. 29, 1575-1591.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 1575-1591
    • Khan, T.1    Muise, E.S.2    Iyengar, P.3    Wang, Z.V.4    Chandalia, M.5    Abate, N.6
  • 141
    • 33750282677 scopus 로고    scopus 로고
    • The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation
    • Kikly, K., Liu, L., Na, S., and Sedgwick, J. D. (2006). The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation. Curr. Opin. Immunol. 18, 670-675.
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 670-675
    • Kikly, K.1    Liu, L.2    Na, S.3    Sedgwick, J.D.4
  • 142
    • 4744370805 scopus 로고    scopus 로고
    • Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-kB
    • Kim, G., Kim, J., Ahn, S., Lee, H., and Moon, D. (2004). Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-kB. Immunology 113, 203-211.
    • (2004) Immunology , vol.113 , pp. 203-211
    • Kim, G.1    Kim, J.2    Ahn, S.3    Lee, H.4    Moon, D.5
  • 143
    • 15844421595 scopus 로고    scopus 로고
    • Recognition of bacterial glycosphingolipids by natural killer T cells
    • Kinjo, Y., Wu, D., Kim, G., Xing, G., Poles, M. A., Ho, D. D., et al. (2005). Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434, 520-525.
    • (2005) Nature , vol.434 , pp. 520-525
    • Kinjo, Y.1    Wu, D.2    Kim, G.3    Xing, G.4    Poles, M.A.5    Ho, D.D.6
  • 144
    • 77952991165 scopus 로고    scopus 로고
    • Adipocyte-derived factors potentiate nutrient-induced production of plasminogen activator inhibitor-1 by macrophages
    • Kishore, P., Li, W., Tonelli, J., Lee, D.-E., Koppaka, S., Zhang, K., et al. (2010). Adipocyte-derived factors potentiate nutrient-induced production of plasminogen activator inhibitor-1 by macrophages. Sci. Transl. Med. 2, 20ra15.
    • (2010) Sci. Transl. Med. , vol.2
    • Kishore, P.1    Li, W.2    Tonelli, J.3    Lee, D.-E.4    Koppaka, S.5    Zhang, K.6
  • 146
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman, P. G. (2000). Obesity as a medical problem. Nature 404, 635-643.
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 147
    • 21244472681 scopus 로고    scopus 로고
    • Effects of marked weight loss on plasma levels of adiponectin, markers of chronic subclinical inflammation and insulin resistance in morbidly obese women
    • Kopp, H.-P., Krzyzanowska, K., Möhlig, M., Spranger, J., Pfeiffer, A. F. H., and Schernthaner, G. (2005). Effects of marked weight loss on plasma levels of adiponectin, markers of chronic subclinical inflammation and insulin resistance in morbidly obese women. Int. J. Obes. (Lond.) 29, 766-771.
    • (2005) Int. J. Obes. (Lond.) , vol.29 , pp. 766-771
    • Kopp, H.-P.1    Krzyzanowska, K.2    Möhlig, M.3    Spranger, J.4    Pfeiffer, A.F.H.5    Schernthaner, G.6
  • 148
    • 68949146083 scopus 로고    scopus 로고
    • mRNA concentrations of MIF in subcutaneous abdominal adipose cells are associated with adipocyte size and insulin action
    • Koska, J., Stefan, N., Dubois, S., Trinidad, C., Considine, R. V., Funahashi, T., et al. (2009). mRNA concentrations of MIF in subcutaneous abdominal adipose cells are associated with adipocyte size and insulin action. Int. J. Obes. (Lond.) 33, 842-850.
    • (2009) Int. J. Obes. (Lond.) , vol.33 , pp. 842-850
    • Koska, J.1    Stefan, N.2    Dubois, S.3    Trinidad, C.4    Considine, R.V.5    Funahashi, T.6
  • 149
    • 77957838795 scopus 로고    scopus 로고
    • Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
    • Kosteli, A., Sugaru, E., Haemmerle, G., Martin, J. F., Lei, J., Zechner, R., et al. (2010). Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J. Clin. Invest. 120, 3466-3479.
    • (2010) J. Clin. Invest. , vol.120 , pp. 3466-3479
    • Kosteli, A.1    Sugaru, E.2    Haemmerle, G.3    Martin, J.F.4    Lei, J.5    Zechner, R.6
  • 151
    • 79953812918 scopus 로고    scopus 로고
    • Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice
    • Kowalski, G. M., Nicholls, H. T., Risis, S., Watson, N. K., Kanellakis, P., Bruce, C. R., et al. (2011). Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice. Diabetologia 54, 888-899.
    • (2011) Diabetologia , vol.54 , pp. 888-899
    • Kowalski, G.M.1    Nicholls, H.T.2    Risis, S.3    Watson, N.K.4    Kanellakis, P.5    Bruce, C.R.6
  • 152
  • 153
    • 33746736936 scopus 로고    scopus 로고
    • Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes
    • Lagathu, C., Yvan-Charvet, L., Bastard, J. P., Maachi, M., Quignard-Boulange, A., Capeau, J., et al. (2006). Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. Diabetologia 49, 2162-2173.
    • (2006) Diabetologia , vol.49 , pp. 2162-2173
    • Lagathu, C.1    Yvan-Charvet, L.2    Bastard, J.P.3    Maachi, M.4    Quignard-Boulange, A.5    Capeau, J.6
  • 156
    • 80052533007 scopus 로고    scopus 로고
    • Identifying metabolically obese but normal-weight (MONW) individuals in a nondiabetic Korean population: the Chungju Metabolic disease Cohort (CMC) study
    • Lee, S.-H., Ha, H.-S., Park, Y.-J., Lee, J.-H., Yim, H.-W., Yoon, K.-H., et al. (2011). Identifying metabolically obese but normal-weight (MONW) individuals in a nondiabetic Korean population: the Chungju Metabolic disease Cohort (CMC) study. Clin. Endocrinol. (Oxf) 75, 475-481.
    • (2011) Clin. Endocrinol. (Oxf) , vol.75 , pp. 475-481
    • Lee, S.-H.1    Ha, H.-S.2    Park, Y.-J.3    Lee, J.-H.4    Yim, H.-W.5    Yoon, K.-H.6
  • 157
    • 33644855564 scopus 로고    scopus 로고
    • Inhibitory effect of green tea (-)-epigallocatechin gallate on resistin gene expression in 3T3-L1 adipocytes depends on the ERK pathway
    • Liu, H.-S., Chen, Y.-H., Hung, P.-F., and Kao, Y.-H. (2006). Inhibitory effect of green tea (-)-epigallocatechin gallate on resistin gene expression in 3T3-L1 adipocytes depends on the ERK pathway. Am. J. Physiol. Endocrinol. Metab. 290, E273-E281.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290
    • Liu, H.-S.1    Chen, Y.-H.2    Hung, P.-F.3    Kao, Y.-H.4
  • 158
    • 70349408730 scopus 로고    scopus 로고
    • Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes
    • Lorente-Cebrián, S., Bustos, M., Marti, A., Martinez, J. A., and Moreno-Aliaga, M. J. (2009). Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes. Clin. Sci. 117, 243-249.
    • (2009) Clin. Sci. , vol.117 , pp. 243-249
    • Lorente-Cebrián, S.1    Bustos, M.2    Marti, A.3    Martinez, J.A.4    Moreno-Aliaga, M.J.5
  • 160
    • 26844478237 scopus 로고    scopus 로고
    • Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction
    • Loscher, C. E., Draper, E., Leavy, O., Kelleher, D., Mills, K. H. G., and Roche, H. M. (2005). Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction. J. Immunol. 175, 4990-4998.
    • (2005) J. Immunol. , vol.175 , pp. 4990-4998
    • Loscher, C.E.1    Draper, E.2    Leavy, O.3    Kelleher, D.4    Mills, K.H.G.5    Roche, H.M.6
  • 162
    • 34547640039 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity
    • Lue, H., Thiele, M., Franz, J., Dahl, E., Speckgens, S., Leng, L., et al. (2007). Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity. Oncogene 26, 5046-5059.
    • (2007) Oncogene , vol.26 , pp. 5046-5059
    • Lue, H.1    Thiele, M.2    Franz, J.3    Dahl, E.4    Speckgens, S.5    Leng, L.6
  • 163
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng, C. N., Bodzin, J. L., and Saltiel, A. R. (2007). Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117, 175-184.
    • (2007) J. Clin. Invest. , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 164
    • 84866520055 scopus 로고    scopus 로고
    • Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
    • Lynch, L., Nowak, M., Varghese, B., Clark, J., Hogan, A. E., Toxavidis, V., et al. (2012). Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity 37, 574-587.
    • (2012) Immunity , vol.37 , pp. 574-587
    • Lynch, L.1    Nowak, M.2    Varghese, B.3    Clark, J.4    Hogan, A.E.5    Toxavidis, V.6
  • 166
    • 69249155107 scopus 로고    scopus 로고
    • Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesity
    • Lynch, L., O'Shea, D., Winter, D. C., Geoghegan, J., Doherty, D. G., and O'Farrelly, C. (2009b). Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesity. Eur. J. Immunol. 39, 1893-1901.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1893-1901
    • Lynch, L.1    O'Shea, D.2    Winter, D.C.3    Geoghegan, J.4    Doherty, D.G.5    O'Farrelly, C.6
  • 167
    • 69049111145 scopus 로고    scopus 로고
    • Functional analyses reveal the greater potency of preadipocytes compared with adipocytes as endothelial cell activator under normoxia, hypoxia, and TNFalpha exposure
    • Mack, I., BelAiba, R. S., Djordjevic, T., Görlach, A., Hauner, H., and Bader, B. L. (2009). Functional analyses reveal the greater potency of preadipocytes compared with adipocytes as endothelial cell activator under normoxia, hypoxia, and TNFalpha exposure. Am. J. Physiol. Endocrinol. Metab. 297, E735-E748.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297
    • Mack, I.1    BelAiba, R.S.2    Djordjevic, T.3    Görlach, A.4    Hauner, H.5    Bader, B.L.6
  • 168
    • 34547911845 scopus 로고    scopus 로고
    • Recent advances in the measurement of adiponectin isoform distribution
    • Magkos, F., and Sidossis, L. S. (2007). Recent advances in the measurement of adiponectin isoform distribution. Curr. Opin. Clin. Nutr. Metab. Care 10, 571-575.
    • (2007) Curr. Opin. Clin. Nutr. Metab. Care , vol.10 , pp. 571-575
    • Magkos, F.1    Sidossis, L.S.2
  • 171
    • 33745224043 scopus 로고    scopus 로고
    • Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle
    • Martin, T. L., Alquier, T., Asakura, K., Furukawa, N., Preitner, F., and Kahn, B. B. (2006). Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J. Biol. Chem. 281, 18933-18941.
    • (2006) J. Biol. Chem. , vol.281 , pp. 18933-18941
    • Martin, T.L.1    Alquier, T.2    Asakura, K.3    Furukawa, N.4    Preitner, F.5    Kahn, B.B.6
  • 172
    • 0034033586 scopus 로고    scopus 로고
    • Caloric restriction and aging: an update
    • Masoro, E. J. (2000). Caloric restriction and aging: an update. Exp. Gerontol. 35, 299-305.
    • (2000) Exp. Gerontol. , vol.35 , pp. 299-305
    • Masoro, E.J.1
  • 173
    • 0032211769 scopus 로고    scopus 로고
    • Signal transduction of stress via ceramide
    • Mathias, S., Pena, L. A., and Kolesnick, R. N. (1998). Signal transduction of stress via ceramide. Biochem. J. 335(Pt 3), 465-480.
    • (1998) Biochem. J. , vol.335 , Issue.PART 3 , pp. 465-480
    • Mathias, S.1    Pena, L.A.2    Kolesnick, R.N.3
  • 174
    • 0141784866 scopus 로고    scopus 로고
    • IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions
    • Matsuki, T., Horai, R., Sudo, K., and Iwakura, Y. (2003). IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions. J. Exp. Med. 198, 877-888.
    • (2003) J. Exp. Med. , vol.198 , pp. 877-888
    • Matsuki, T.1    Horai, R.2    Sudo, K.3    Iwakura, Y.4
  • 175
    • 84870450944 scopus 로고    scopus 로고
    • Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals
    • McEneny, J., Wade, L., Young, I. S., Masson, L., Duthie, G., McGinty, A., et al. (2012). Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals. J. Nutr. Biochem. 1, 163-168.
    • (2012) J. Nutr. Biochem. , vol.1 , pp. 163-168
    • McEneny, J.1    Wade, L.2    Young, I.S.3    Masson, L.4    Duthie, G.5    McGinty, A.6
  • 176
    • 70450277113 scopus 로고    scopus 로고
    • Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway
    • McGillicuddy, F. C., Chiquoine, E. H., Hinkle, C. C., Kim, R. J., Shah, R., Roche, H. M., et al. (2009). Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J. Biol. Chem. 284, 31936-31944.
    • (2009) J. Biol. Chem. , vol.284 , pp. 31936-31944
    • McGillicuddy, F.C.1    Chiquoine, E.H.2    Hinkle, C.C.3    Kim, R.J.4    Shah, R.5    Roche, H.M.6
  • 177
    • 79959438318 scopus 로고    scopus 로고
    • Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis
    • McGillicuddy, F. C., Harford, K. A., Reynolds, C. M., Oliver, E., Claessens, M., Mills, K. H. G., et al. (2011). Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis. Diabetes 60, 1688-1698.
    • (2011) Diabetes , vol.60 , pp. 1688-1698
    • McGillicuddy, F.C.1    Harford, K.A.2    Reynolds, C.M.3    Oliver, E.4    Claessens, M.5    Mills, K.H.G.6
  • 178
    • 14644388121 scopus 로고    scopus 로고
    • Regulatory cells and the control of respiratory infection
    • McGuirk, P., Higgins, S. C., and Mills, K. H. G. (2005). Regulatory cells and the control of respiratory infection. Curr. Allergy Asthma Rep. 5, 51-55.
    • (2005) Curr. Allergy Asthma Rep. , vol.5 , pp. 51-55
    • McGuirk, P.1    Higgins, S.C.2    Mills, K.H.G.3
  • 179
    • 34447130417 scopus 로고    scopus 로고
    • Enhanced proportion of small adipose cells in insulin-resistant vs insulinsensitive obese individuals implicates impaired adipogenesis
    • McLaughlin, T., Sherman, A., Tsao, P., Gonzalez, O., Yee, G., Lamendola, C., et al. (2007). Enhanced proportion of small adipose cells in insulin-resistant vs insulinsensitive obese individuals implicates impaired adipogenesis. Diabetologia 50, 1707-1715.
    • (2007) Diabetologia , vol.50 , pp. 1707-1715
    • McLaughlin, T.1    Sherman, A.2    Tsao, P.3    Gonzalez, O.4    Yee, G.5    Lamendola, C.6
  • 180
    • 71549173455 scopus 로고    scopus 로고
    • Immune modulation: IL-1, master mediator or initiator of inflammation
    • Mills, K. H., and Dunne, A. (2009). Immune modulation: IL-1, master mediator or initiator of inflammation. Nat. Med. 15, 1363-1364.
    • (2009) Nat. Med. , vol.15 , pp. 1363-1364
    • Mills, K.H.1    Dunne, A.2
  • 181
    • 0037039308 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response
    • Mitchell, R. A., Liao, H., Chesney, J., Fingerle-Rowson, G., Baugh, J., David, J., et al. (2002). Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response. Proc. Natl. Acad. Sci. U.S.A. 99, 345-350.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 345-350
    • Mitchell, R.A.1    Liao, H.2    Chesney, J.3    Fingerle-Rowson, G.4    Baugh, J.5    David, J.6
  • 182
    • 0037223174 scopus 로고    scopus 로고
    • Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
    • Mokdad, A. H., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., Bales, V. S., et al. (2003). Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289, 76-79.
    • (2003) JAMA , vol.289 , pp. 76-79
    • Mokdad, A.H.1    Ford, E.S.2    Bowman, B.A.3    Dietz, W.H.4    Vinicor, F.5    Bales, V.S.6
  • 184
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser, D. M., and Edwards, J. P. (2008). Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958-969.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 185
    • 25144454432 scopus 로고    scopus 로고
    • Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
    • Moynihan, K. A., Grimm, A. A., Plueger, M. M., Bernal-Mizrachi, E., Ford, E., Cras-Méneur, C., et al. (2005). Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab. 2, 105-117.
    • (2005) Cell Metab. , vol.2 , pp. 105-117
    • Moynihan, K.A.1    Grimm, A.A.2    Plueger, M.M.3    Bernal-Mizrachi, E.4    Ford, E.5    Cras-Méneur, C.6
  • 186
    • 0037365968 scopus 로고    scopus 로고
    • Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling
    • Nathan, C. (2003). Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. J. Clin. Invest. 111, 769-778.
    • (2003) J. Clin. Invest. , vol.111 , pp. 769-778
    • Nathan, C.1
  • 187
    • 33745305434 scopus 로고    scopus 로고
    • Fish oil regulates adiponectin secretion by a receptor-y-dependent mechanism in mice
    • Neschen, S., Morino, K., Rossbacher, C., Pongratz, R. L., Cline, G. W., Sono, S., et al. (2006). Fish oil regulates adiponectin secretion by a receptor-y-dependent mechanism in mice. Diabetes 55, 924-928.
    • (2006) Diabetes , vol.55 , pp. 924-928
    • Neschen, S.1    Morino, K.2    Rossbacher, C.3    Pongratz, R.L.4    Cline, G.W.5    Sono, S.6
  • 188
    • 64049084303 scopus 로고    scopus 로고
    • Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    • Netea, M. G., Nold-Petry, C. A., Nold, M. F., Joosten, L. A., Opitz, B., Van der Meer, J. H., et al. (2009). Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 113, 2324-2335.
    • (2009) Blood , vol.113 , pp. 2324-2335
    • Netea, M.G.1    Nold-Petry, C.A.2    Nold, M.F.3    Joosten, L.A.4    Opitz, B.5    Van der Meer, J.H.6
  • 190
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    • Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K. K., Reichart, D., Scott, P. A., Jenn, A., et al. (2007). A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J. Biol. Chem. 282, 35279-35292.
    • (2007) J. Biol. Chem. , vol.282 , pp. 35279-35292
    • Nguyen, M.T.A.1    Favelyukis, S.2    Nguyen, A.-K.K.3    Reichart, D.4    Scott, P.A.5    Jenn, A.6
  • 191
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., et al. (2009). CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15, 914-920.
    • (2009) Nat. Med. , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4    Yamashita, H.5    Ohsugi, M.6
  • 192
    • 84865747655 scopus 로고    scopus 로고
    • Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer
    • Nishio, M., Yoneshiro, T., Nakahara, M., Suzuki, S., Saeki, K. K., Hasegawa, M., et al. (2012). Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab. 16, 394-406.
    • (2012) Cell Metab. , vol.16 , pp. 394-406
    • Nishio, M.1    Yoneshiro, T.2    Nakahara, M.3    Suzuki, S.4    Saeki, K.K.5    Hasegawa, M.6
  • 193
    • 77956321989 scopus 로고    scopus 로고
    • The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity
    • doi:10.1371/journal.pone.0009997
    • O'Connell, J., Lynch, L., Cawood, T. J., Kwasnik, A., Nolan, N., Geoghegan, J., et al. (2010). The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. PLoS ONE 5:e9997. doi:10.1371/journal.pone.0009997
    • (2010) PLoS ONE , vol.5
    • O'Connell, J.1    Lynch, L.2    Cawood, T.J.3    Kwasnik, A.4    Nolan, N.5    Geoghegan, J.6
  • 195
    • 44349161098 scopus 로고    scopus 로고
    • Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
    • Odegaard, J. I., Ricardo-Gonzalez, R. R., Red Eagle, A., Vats, D., Morel, C. R., Goforth, M. H., et al. (2008). Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab. 7, 496-507.
    • (2008) Cell Metab. , vol.7 , pp. 496-507
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Red Eagle, A.3    Vats, D.4    Morel, C.R.5    Goforth, M.H.6
  • 196
    • 84856533216 scopus 로고    scopus 로고
    • Increased macrophage migration into adipose tissue in obese mice
    • Oh, D. Y., Morinaga, H., Talukdar, S., Bae, E. J., and Olefsky, J. M. (2012). Increased macrophage migration into adipose tissue in obese mice. Diabetes 61, 346-354.
    • (2012) Diabetes , vol.61 , pp. 346-354
    • Oh, D.Y.1    Morinaga, H.2    Talukdar, S.3    Bae, E.J.4    Olefsky, J.M.5
  • 197
    • 77956165390 scopus 로고    scopus 로고
    • GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
    • Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., et al. (2010). GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142, 687-698.
    • (2010) Cell , vol.142 , pp. 687-698
    • Oh, D.Y.1    Talukdar, S.2    Bae, E.J.3    Imamura, T.4    Morinaga, H.5    Fan, W.6
  • 198
    • 84865086635 scopus 로고    scopus 로고
    • Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA
    • Oliver, E., McGillicuddy, F. C., Harford, K. A., Reynolds, C. M., Phillips, C. M., Ferguson, J. F., et al. (2012). Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA. J. Nutr. Biochem. 23, 1192-1200.
    • (2012) J. Nutr. Biochem. , vol.23 , pp. 1192-1200
    • Oliver, E.1    McGillicuddy, F.C.2    Harford, K.A.3    Reynolds, C.M.4    Phillips, C.M.5    Ferguson, J.F.6
  • 199
    • 84868026167 scopus 로고    scopus 로고
    • Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages
    • Orr, J. S., Puglisi, M. J., Ellacott, K. L. J., Lumeng, C. N., Wasserman, D. H., and Hasty, A. H. (2012). Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. Diabetes 61, 2718-2727.
    • (2012) Diabetes , vol.61 , pp. 2718-2727
    • Orr, J.S.1    Puglisi, M.J.2    Ellacott, K.L.J.3    Lumeng, C.N.4    Wasserman, D.H.5    Hasty, A.H.6
  • 200
    • 84873403803 scopus 로고    scopus 로고
    • The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness
    • Ortega, F. B., Lee, D.-C., Katzmarzyk, P. T., Ruiz, J. R., Sui, X., Church, T. S., et al. (2013). The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness. Eur. Heart J. 34, 389-397.
    • (2013) Eur. Heart J. , vol.34 , pp. 389-397
    • Ortega, F.B.1    Lee, D.-C.2    Katzmarzyk, P.T.3    Ruiz, J.R.4    Sui, X.5    Church, T.S.6
  • 201
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • Osborn, O., and Olefsky, J. M. (2012). The cellular and signaling networks linking the immune system and metabolism in disease. Nat. Med. 18, 363-374.
    • (2012) Nat. Med. , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 202
    • 77952508043 scopus 로고    scopus 로고
    • Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke
    • doi:10.1371/journal.pone.0008660
    • O'Shea, D., Cawood, T. J., O'Farrelly, C., and Lynch, L. (2010). Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PLoS ONE 5:e8660. doi:10.1371/journal.pone.0008660
    • (2010) PLoS ONE , vol.5
    • O'Shea, D.1    Cawood, T.J.2    O'Farrelly, C.3    Lynch, L.4
  • 203
    • 0031895668 scopus 로고    scopus 로고
    • Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running
    • Ostrowski, K., Rohde, T., Zacho, M., Asp, S., and Pedersen, B. K. (1998). Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. J. Physiol. (Lond.) 508, 949-953.
    • (1998) J. Physiol. (Lond.) , vol.508 , pp. 949-953
    • Ostrowski, K.1    Rohde, T.2    Zacho, M.3    Asp, S.4    Pedersen, B.K.5
  • 205
    • 78650098848 scopus 로고    scopus 로고
    • Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans
    • Ouellet, V., Routhier-Labadie, A., Bellemare, W., Lakhal-Chaieb, L., Turcotte, E., Carpentier, A. C., et al. (2011). Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. J. Clin. Endocrinol. Metab. 96, 192-199.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 192-199
    • Ouellet, V.1    Routhier-Labadie, A.2    Bellemare, W.3    Lakhal-Chaieb, L.4    Turcotte, E.5    Carpentier, A.C.6
  • 206
    • 35348969719 scopus 로고    scopus 로고
    • Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: their inhibition by resveratrol
    • Park, S. Y., Jeong, K. J., Lee, J., Yoon, D. S., Choi, W. S., Kim, Y. K., et al. (2007). Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: their inhibition by resveratrol. Cancer Lett. 258, 63-69.
    • (2007) Cancer Lett. , vol.258 , pp. 63-69
    • Park, S.Y.1    Jeong, K.J.2    Lee, J.3    Yoon, D.S.4    Choi, W.S.5    Kim, Y.K.6
  • 207
    • 78651379305 scopus 로고    scopus 로고
    • Muscles and their myokines
    • Pedersen, B. K. (2011). Muscles and their myokines. J. Exp. Biol. 214, 337-346.
    • (2011) J. Exp. Biol. , vol.214 , pp. 337-346
    • Pedersen, B.K.1
  • 208
    • 55949119252 scopus 로고    scopus 로고
    • Muscle as an endocrine organ: focus on muscle-derived interleukin-6
    • Pedersen, B. K., and Febbraio, M. A. (2008). Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol. Rev. 88, 1379-1406.
    • (2008) Physiol. Rev. , vol.88 , pp. 1379-1406
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 209
    • 84864283300 scopus 로고    scopus 로고
    • Muscles, exercise and obesity: skeletal muscle as a secretory organ
    • Pedersen, B. K., and Febbraio, M. A. (2012). Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 8, 457-465.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 457-465
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 210
    • 0037026745 scopus 로고    scopus 로고
    • Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus
    • Petersen, K. F., and Shulman, G. I. (2002). Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. Am. J. Cardiol. 90, 11G-18G.
    • (2002) Am. J. Cardiol. , vol.90
    • Petersen, K.F.1    Shulman, G.I.2
  • 211
  • 212
    • 72749099788 scopus 로고    scopus 로고
    • Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome 1 - 3
    • Phillips, C. M., Goumidi, L., Bertrais, S., Ferguson, J. F., Field, M. R., Kelly, E. D., et al. (2009a). Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome 1 - 3. Am. J. Clin. Nutr. 90, 1665-1673.
    • (2009) Am. J. Clin. Nutr. , vol.90 , pp. 1665-1673
    • Phillips, C.M.1    Goumidi, L.2    Bertrais, S.3    Ferguson, J.F.4    Field, M.R.5    Kelly, E.D.6
  • 213
    • 70350290243 scopus 로고    scopus 로고
    • Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults
    • Phillips, C. M., Goumidi, L., Bertrais, S., Field, M. R., Peloso, G. M., Shen, J., et al. (2009b). Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults. J. Nutr. 139, 2011-2017.
    • (2009) J. Nutr. , vol.139 , pp. 2011-2017
    • Phillips, C.M.1    Goumidi, L.2    Bertrais, S.3    Field, M.R.4    Peloso, G.M.5    Shen, J.6
  • 214
    • 70449533779 scopus 로고    scopus 로고
    • No effect of fish oil supplementation on serum inflammatory markers and their interrelationships: a randomized controlled trial in healthy, middle-aged individuals
    • Pot, G. K., Brouwer, I. A., Enneman, A., Rijkers, G. T., Kampman, E., and Geelen, A. (2009). No effect of fish oil supplementation on serum inflammatory markers and their interrelationships: a randomized controlled trial in healthy, middle-aged individuals. Eur. J. Clin. Nutr. 63, 1353-1359.
    • (2009) Eur. J. Clin. Nutr. , vol.63 , pp. 1353-1359
    • Pot, G.K.1    Brouwer, I.A.2    Enneman, A.3    Rijkers, G.T.4    Kampman, E.5    Geelen, A.6
  • 215
    • 33947637709 scopus 로고    scopus 로고
    • Preadipocyte response and impairment of differentiation in an inflammatory environment
    • Poulain-Godefroy, O., and Froguel, P. (2007). Preadipocyte response and impairment of differentiation in an inflammatory environment. Biochem. Biophys. Res. Commun. 356, 662-667.
    • (2007) Biochem. Biophys. Res. Commun. , vol.356 , pp. 662-667
    • Poulain-Godefroy, O.1    Froguel, P.2
  • 217
    • 70350150677 scopus 로고    scopus 로고
    • Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism
    • Pricola, K. L., Kuhn, N. Z., Haleem-Smith, H., Song, Y., and Tuan, R. S. (2009). Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism. J. Cell. Biochem. 108, 577-588.
    • (2009) J. Cell. Biochem. , vol.108 , pp. 577-588
    • Pricola, K.L.1    Kuhn, N.Z.2    Haleem-Smith, H.3    Song, Y.4    Tuan, R.S.5
  • 218
    • 79952437112 scopus 로고    scopus 로고
    • Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice
    • Prieur, X., Mok, C. Y. L., Velagapudi, V. R., Núñez, V., Fuentes, L., Montaner, D., et al. (2011). Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes 60, 797-809.
    • (2011) Diabetes , vol.60 , pp. 797-809
    • Prieur, X.1    Mok, C.Y.L.2    Velagapudi, V.R.3    Núñez, V.4    Fuentes, L.5    Montaner, D.6
  • 219
    • 84865108051 scopus 로고    scopus 로고
    • Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance
    • Reynolds, C. M., McGillicuddy, F. C., Harford, K. A., Finucane, O. M., Mills, K. H. G., and Roche, H. M. (2012). Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. Mol. Nutr. Food Res. 56, 1212-1222.
    • (2012) Mol. Nutr. Food Res. , vol.56 , pp. 1212-1222
    • Reynolds, C.M.1    McGillicuddy, F.C.2    Harford, K.A.3    Finucane, O.M.4    Mills, K.H.G.5    Roche, H.M.6
  • 220
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., and Glass, C. K. (1998). The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391, 79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 222
    • 0035924325 scopus 로고    scopus 로고
    • MIF regulates innate immune responses through modulation of Toll-like receptor 4
    • Roger, T., David, J., Glauser, M. P., and Calandra, T. (2001). MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature 414, 920- 924.
    • (2001) Nature , vol.414
    • Roger, T.1    David, J.2    Glauser, M.P.3    Calandra, T.4
  • 224
    • 0036313033 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory
    • Ruan, H., Hacohen, N., Golub, T. R., Van Parijs, L., and Lodish, H. F. (2002). Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. Diabetes 51, 1319-1336.
    • (2002) Diabetes , vol.51 , pp. 1319-1336
    • Ruan, H.1    Hacohen, N.2    Golub, T.R.3    Van Parijs, L.4    Lodish, H.F.5
  • 225
    • 0019603446 scopus 로고
    • The "metabolically-obese," normal-weight individual
    • Ruderman, N. B., Schneider, S. H., and Berchtold, P. (1981). The "metabolically-obese," normal-weight individual. Am. J. Clin. Nutr. 34, 1617-1621.
    • (1981) Am. J. Clin. Nutr. , vol.34 , pp. 1617-1621
    • Ruderman, N.B.1    Schneider, S.H.2    Berchtold, P.3
  • 226
    • 65549113825 scopus 로고    scopus 로고
    • Acute hyperinsulinemia raises plasma interleukin-6 in both nondiabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass index
    • Ruge, T., Lockton, J. A., Renstrom, F., Lystig, T., Sukonina, V., Svensson, M. K., et al. (2009). Acute hyperinsulinemia raises plasma interleukin-6 in both nondiabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass index. Metab. Clin. Exp. 58, 860-866.
    • (2009) Metab. Clin. Exp. , vol.58 , pp. 860-866
    • Ruge, T.1    Lockton, J.A.2    Renstrom, F.3    Lystig, T.4    Sukonina, V.5    Svensson, M.K.6
  • 227
    • 70350389389 scopus 로고    scopus 로고
    • Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
    • Saberi, M., Woods, N.-B. B., De Luca, C., Schenk, S., Lu, J. C., Bandyopadhyay, G., et al. (2009). Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 10, 419-429.
    • (2009) Cell Metab. , vol.10 , pp. 419-429
    • Saberi, M.1    Woods, N.-B.B.2    De Luca, C.3    Schenk, S.4    Lu, J.C.5    Bandyopadhyay, G.6
  • 228
    • 32944464959 scopus 로고    scopus 로고
    • Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns
    • Sadeghi, K., Wessner, B., Laggner, U., Ploder, M., Tamandl, D., Friedl, J., et al. (2006). Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur. J. Immunol. 36, 361-370.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 361-370
    • Sadeghi, K.1    Wessner, B.2    Laggner, U.3    Ploder, M.4    Tamandl, D.5    Friedl, J.6
  • 230
    • 67650242165 scopus 로고    scopus 로고
    • High incidence of metabolically active brown adipose effects of cold exposure and adiposity
    • Saito, M., Okamatsu-ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-kobayashi, J., et al. (2009). High incidence of metabolically active brown adipose effects of cold exposure and adiposity. Diabetes 58, 1526-1531.
    • (2009) Diabetes , vol.58 , pp. 1526-1531
    • Saito, M.1    Okamatsu-ogura, Y.2    Matsushita, M.3    Watanabe, K.4    Yoneshiro, T.5    Nio-kobayashi, J.6
  • 231
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor ??
    • Sallusto, F., and Lanzavecchia, A. (1994). Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor ??. J. Exp. Med. 179, 1109-1118.
    • (1994) J. Exp. Med. , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 232
    • 77954453333 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor is a therapeutic target in treatment of non-insulin-dependent diabetes mellitus
    • Sanchez-Zamora, Y., Terrazas, L. I., Vilches-Flores, A., Leal, E., Juárez, I., Whitacre, C., et al. (2010). Macrophage migration inhibitory factor is a therapeutic target in treatment of non-insulin-dependent diabetes mellitus. FASEB J. 24, 2583-2590.
    • (2010) FASEB J. , vol.24 , pp. 2583-2590
    • Sanchez-Zamora, Y.1    Terrazas, L.I.2    Vilches-Flores, A.3    Leal, E.4    Juárez, I.5    Whitacre, C.6
  • 233
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva, M., and O'Garra, A. (2010). The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 10, 170-181.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 234
    • 42449091550 scopus 로고    scopus 로고
    • The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia
    • Sauter, N. S., Schulthess, F. T., Galasso, R., Castellani, L. W., and Maedler, K. (2008). The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia. Endocrinology 149, 2208-2218.
    • (2008) Endocrinology , vol.149 , pp. 2208-2218
    • Sauter, N.S.1    Schulthess, F.T.2    Galasso, R.3    Castellani, L.W.4    Maedler, K.5
  • 235
    • 84862729680 scopus 로고    scopus 로고
    • Satellite cells derived from obese humans with type 2 diabetes and differentiated into myocytes in vitro exhibit abnormal response to IL-6
    • doi:10.1371/journal.pone.0039657
    • Scheele, C., Nielsen, S., Kelly, M., Broholm, C., Nielsen, A. R., Taudorf, S., et al. (2012). Satellite cells derived from obese humans with type 2 diabetes and differentiated into myocytes in vitro exhibit abnormal response to IL-6. PLoS ONE 7:e39657. doi:10.1371/journal.pone.0039657
    • (2012) PLoS ONE , vol.7
    • Scheele, C.1    Nielsen, S.2    Kelly, M.3    Broholm, C.4    Nielsen, A.R.5    Taudorf, S.6
  • 236
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: modulation by nutrients and inflammation
    • Schenk, S., Saberi, M., and Olefsky, J. M. (2008). Insulin sensitivity: modulation by nutrients and inflammation. J. Clin. Invest. 118, 2992-3002.
    • (2008) J. Clin. Invest. , vol.118 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 237
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer, P. E., Williams, S., Fogliano, M., Baldini, G., and Lodish, H. F. (1995). A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270, 26746-26749.
    • (1995) J. Biol. Chem. , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 239
    • 0033527549 scopus 로고    scopus 로고
    • Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding
    • Schottelius, A. J., Mayo, M. W., Sartor, R. B., and Baldwin, A. S. Jr. (1999). Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding. J. Biol. Chem. 274, 31868-31874.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31868-31874
    • Schottelius, A.J.1    Mayo, M.W.2    Sartor, R.B.3    Baldwin, A.S.Jr.4
  • 240
    • 0037216466 scopus 로고    scopus 로고
    • Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming highfat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets
    • Schwarz, J. M., Linfoot, P., Dare, D., and Aghajanian, K. (2003). Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming highfat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am. J. Clin. Nutr. 77, 43-50.
    • (2003) Am. J. Clin. Nutr. , vol.77 , pp. 43-50
    • Schwarz, J.M.1    Linfoot, P.2    Dare, D.3    Aghajanian, K.4
  • 241
    • 0036312905 scopus 로고    scopus 로고
    • Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    • Seppala-Lindroos, A., Vehkavaara, S., Hakkinen, A. M., Goto, T., Westerbacka, J., Sovijarvi, A., et al. (2002). Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J. Clin. Endocrinol. Metab. 87, 3023-3028.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 3023-3028
    • Seppala-Lindroos, A.1    Vehkavaara, S.2    Hakkinen, A.M.3    Goto, T.4    Westerbacka, J.5    Sovijarvi, A.6
  • 242
    • 77955613355 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor deficiency leads to age-dependent impairment of glucose homeostasis in mice
    • Serre-Beinier, V., Toso, C., Morel, P., Gonelle-Gispert, C., Veyrat-Durebex, C., Rohner-Jeanrenaud, F., et al. (2010). Macrophage migration inhibitory factor deficiency leads to age-dependent impairment of glucose homeostasis in mice. J. Endocrinol. 206, 297-306.
    • (2010) J. Endocrinol. , vol.206 , pp. 297-306
    • Serre-Beinier, V.1    Toso, C.2    Morel, P.3    Gonelle-Gispert, C.4    Veyrat-Durebex, C.5    Rohner-Jeanrenaud, F.6
  • 244
    • 34347205695 scopus 로고    scopus 로고
    • Interactions among peroxisome proliferator activated receptor-gamma, insulin signaling pathways, and steroidogenic acute regulatory protein in human ovarian cells
    • Seto-Young, D., Avtanski, D., Strizhevsky, M., Parikh, G., Patel, P., Kaplun, J., et al. (2007). Interactions among peroxisome proliferator activated receptor-gamma, insulin signaling pathways, and steroidogenic acute regulatory protein in human ovarian cells. J. Clin. Endocrinol. Metab. 92, 2232-2239.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 2232-2239
    • Seto-Young, D.1    Avtanski, D.2    Strizhevsky, M.3    Parikh, G.4    Patel, P.5    Kaplun, J.6
  • 245
    • 0034280106 scopus 로고    scopus 로고
    • Natural killer cells determine the outcome of B cell-mediated autoimmunity
    • Shi, F. D., Wang, H. B., Li, H., Hong, S., Taniguchi, M., Link, H., et al. (2000). Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nat. Immunol. 1, 245-251.
    • (2000) Nat. Immunol. , vol.1 , pp. 245-251
    • Shi, F.D.1    Wang, H.B.2    Li, H.3    Hong, S.4    Taniguchi, M.5    Link, H.6
  • 246
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., and Flier, J. S. (2006). TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116, 3015-3025.
    • (2006) J. Clin. Invest. , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3    Tzameli, I.4    Yin, H.5    Flier, J.S.6
  • 247
    • 84867030992 scopus 로고    scopus 로고
    • Metabolic consequences of high-fat diet are attenuated by suppression of HIF -1??
    • doi:10.1371/journal.pone.0046562
    • Shin, M.-K., Drager, L. F., Yao, Q., Bevans-Fonti, S., Yoo, D.-Y., Jun, J. C., et al. (2012). Metabolic consequences of high-fat diet are attenuated by suppression of HIF -1??. PLoS ONE 7:e46562. doi:10.1371/journal.pone.0046562
    • (2012) PLoS ONE , vol.7
    • Shin, M.-K.1    Drager, L.F.2    Yao, Q.3    Bevans-Fonti, S.4    Yoo, D.-Y.5    Jun, J.C.6
  • 248
    • 0346880505 scopus 로고    scopus 로고
    • Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance
    • Shoelson, S. E., Lee, J., and Yuan, M. (2003). Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int. J. Obes. Relat. Metab. Disord. 27(Suppl. 3), S49-S52.
    • (2003) Int. J. Obes. Relat. Metab. Disord. , vol.27 , Issue.SUPPL. 3
    • Shoelson, S.E.1    Lee, J.2    Yuan, M.3
  • 249
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman, G. I. (2000). Cellular mechanisms of insulin resistance. J. Clin. Invest. 106, 171-176.
    • (2000) J. Clin. Invest. , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 250
    • 0025098765 scopus 로고
    • Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
    • Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., and Shulman, R. G. (1990). Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N. Engl. J. Med. 322, 223-228.
    • (1990) N. Engl. J. Med. , vol.322 , pp. 223-228
    • Shulman, G.I.1    Rothman, D.L.2    Jue, T.3    Stein, P.4    DeFronzo, R.A.5    Shulman, R.G.6
  • 251
    • 0028867742 scopus 로고
    • Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]
    • Singh, S., and Aggarwal, B. B. (1995). Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. J. Biol. Chem. 270, 24995-25000.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24995-25000
    • Singh, S.1    Aggarwal, B.B.2
  • 252
    • 14244269670 scopus 로고    scopus 로고
    • Production and release of macrophage migration inhibitory factor from human adipocytes
    • Skurk, T., Herder, C., Kraft, I., Muller-Scholze, S., Hauner, H., and Kolb, H. (2005). Production and release of macrophage migration inhibitory factor from human adipocytes. Endocrinology 146, 1006-1011.
    • (2005) Endocrinology , vol.146 , pp. 1006-1011
    • Skurk, T.1    Herder, C.2    Kraft, I.3    Muller-Scholze, S.4    Hauner, H.5    Kolb, H.6
  • 253
    • 0028116159 scopus 로고
    • Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice
    • Sohal, R. S., Agarwal, S., Candas, M., Forster, M. J., and Lal, H. (1994). Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech. Ageing Dev. 76, 215-224.
    • (1994) Mech. Ageing Dev. , vol.76 , pp. 215-224
    • Sohal, R.S.1    Agarwal, S.2    Candas, M.3    Forster, M.J.4    Lal, H.5
  • 254
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal, R. S., and Weindruch, R. (1996). Oxidative stress, caloric restriction, and aging. Science 273, 59-63.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 255
    • 0345700727 scopus 로고    scopus 로고
    • Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    • Spranger, J., Kroke, A., Mohlig, M., Hoffmann, K., Bergmann, M. M., Ristow, M., et al. (2003). Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 52, 812-817.
    • (2003) Diabetes , vol.52 , pp. 812-817
    • Spranger, J.1    Kroke, A.2    Mohlig, M.3    Hoffmann, K.4    Bergmann, M.M.5    Ristow, M.6
  • 256
    • 0034668926 scopus 로고    scopus 로고
    • Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6
    • Steensberg, A., Van Hall, G., Osada, T., Sacchetti, M., Saltin, B., and Klarlund Pedersen, B. (2000). Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J. Physiol. (Lond.) 529, 237-242.
    • (2000) J. Physiol. (Lond.) , vol.529 , pp. 237-242
    • Steensberg, A.1    Van Hall, G.2    Osada, T.3    Sacchetti, M.4    Saltin, B.5    Klarlund Pedersen, B.6
  • 257
    • 49449092403 scopus 로고    scopus 로고
    • Identification and characterization of metabolically benign obesity in humans
    • Stefan, N., Kantartzis, K., Machann, J., Schick, F., Thamer, C., Rittig, K., et al. (2008). Identification and characterization of metabolically benign obesity in humans. Arch. Intern. Med. 168, 1609-1616.
    • (2008) Arch. Intern. Med. , vol.168 , pp. 1609-1616
    • Stefan, N.1    Kantartzis, K.2    Machann, J.3    Schick, F.4    Thamer, C.5    Rittig, K.6
  • 258
    • 84865460082 scopus 로고    scopus 로고
    • Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver
    • Stefanovic-Racic, M., Yang, X., Turner, M. S., Mantell, B. S., Stolz, D. B., Sumpter, T. L., et al. (2012). Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver. Diabetes 61, 2330-2339.
    • (2012) Diabetes , vol.61 , pp. 2330-2339
    • Stefanovic-Racic, M.1    Yang, X.2    Turner, M.S.3    Mantell, B.S.4    Stolz, D.B.5    Sumpter, T.L.6
  • 260
    • 78649498271 scopus 로고    scopus 로고
    • The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
    • Stienstra, R., Joosten, L. A., Koenen, T., Van Tits, B., Van Diepen, J. A., Van den Berg, S. A., et al. (2010). The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab. 12, 593-605.
    • (2010) Cell Metab. , vol.12 , pp. 593-605
    • Stienstra, R.1    Joosten, L.A.2    Koenen, T.3    Van Tits, B.4    Van Diepen, J.A.5    Van den Berg, S.A.6
  • 261
    • 77957108166 scopus 로고    scopus 로고
    • T-cell recruitment and Th1 polarization in adipose tissue during dietinduced obesity in C57BL/6 mice
    • Strissel, K. J., DeFuria, J., Shaul, M. E., Bennett, G., Greenberg, A. S., and Obin, M. S. (2010). T-cell recruitment and Th1 polarization in adipose tissue during dietinduced obesity in C57BL/6 mice. Obesity (Silver Spring) 18, 1918-1925.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 1918-1925
    • Strissel, K.J.1    DeFuria, J.2    Shaul, M.E.3    Bennett, G.4    Greenberg, A.S.5    Obin, M.S.6
  • 263
    • 48749105019 scopus 로고    scopus 로고
    • Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals
    • Succurro, E., Marini, M. A., Frontoni, S., Hribal, M. L., Andreozzi, F., Lauro, R., et al. (2008). Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals. Obesity (Silver Spring) 16, 1881-1886.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 1881-1886
    • Succurro, E.1    Marini, M.A.2    Frontoni, S.3    Hribal, M.L.4    Andreozzi, F.5    Lauro, R.6
  • 264
    • 31644443192 scopus 로고    scopus 로고
    • Ceramides in insulin resistance and lipotoxicity
    • Summers, S. A. (2006). Ceramides in insulin resistance and lipotoxicity. Prog. Lipid Res. 45, 42-72.
    • (2006) Prog. Lipid Res. , vol.45 , pp. 42-72
    • Summers, S.A.1
  • 265
    • 34548857700 scopus 로고    scopus 로고
    • SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
    • Sun, C., Zhang, F., Ge, X., Yan, T., Chen, X., Shi, X., et al. (2007). SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 6, 307-319.
    • (2007) Cell Metab. , vol.6 , pp. 307-319
    • Sun, C.1    Zhang, F.2    Ge, X.3    Yan, T.4    Chen, X.5    Shi, X.6
  • 266
    • 79957916782 scopus 로고    scopus 로고
    • Adipose tissue remodeling and obesity
    • Sun, K., Kusminski, C. M., and Scherer, P. E. (2011). Adipose tissue remodeling and obesity. J. Clin. Invest. 121, 2094-2101.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2094-2101
    • Sun, K.1    Kusminski, C.M.2    Scherer, P.E.3
  • 267
    • 84865289995 scopus 로고    scopus 로고
    • Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family
    • Tack, C. J., Stienstra, R., Joosten, L. A., and Netea, M. G. (2012). Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family. Immunol. Rev. 249, 239-252.
    • (2012) Immunol. Rev. , vol.249 , pp. 239-252
    • Tack, C.J.1    Stienstra, R.2    Joosten, L.A.3    Netea, M.G.4
  • 268
    • 18244387691 scopus 로고    scopus 로고
    • Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease
    • Tamura, S., and Shimomura, I. (2005). Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease. J. Clin. Invest. 115, 1139-1142.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1139-1142
    • Tamura, S.1    Shimomura, I.2
  • 269
    • 84860293753 scopus 로고    scopus 로고
    • Effect of a tomato-rich diet on markers of cardiovascular disease risk in moderately overweight, disease-free, middle-aged adults: a randomized controlled trial
    • Thies, F., Masson, L. F., Rudd, A., Vaughan, N., Tsang, C., Brittenden, J., et al. (2012). Effect of a tomato-rich diet on markers of cardiovascular disease risk in moderately overweight, disease-free, middle-aged adults: a randomized controlled trial. Am. J. Clin. Nutr. 95, 1013-1022.
    • (2012) Am. J. Clin. Nutr. , vol.95 , pp. 1013-1022
    • Thies, F.1    Masson, L.F.2    Rudd, A.3    Vaughan, N.4    Tsang, C.5    Brittenden, J.6
  • 270
    • 79958795239 scopus 로고    scopus 로고
    • Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome - LIPGENE: a European randomized dietary intervention study
    • Tierney, A., McMonagle, J., Shaw, D. I., Gulseth, H. L., Helal, O., Saris, W. H. M., et al. (2011). Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome - LIPGENE: a European randomized dietary intervention study. Int. J. Obes. (Lond.) 35, 800-809.
    • (2011) Int. J. Obes. (Lond.) , vol.35 , pp. 800-809
    • Tierney, A.1    McMonagle, J.2    Shaw, D.I.3    Gulseth, H.L.4    Helal, O.5    Saris, W.H.M.6
  • 271
    • 79651474666 scopus 로고    scopus 로고
    • Reactive oxygen species and insulin resistance: the good, the bad and the ugly
    • Tiganis, T. (2011). Reactive oxygen species and insulin resistance: the good, the bad and the ugly. Trends Pharmacol. Sci. 32, 82-89.
    • (2011) Trends Pharmacol. Sci. , vol.32 , pp. 82-89
    • Tiganis, T.1
  • 272
    • 41649093318 scopus 로고    scopus 로고
    • Inflammatory mechanisms in the regulation of insulin resistance
    • Tilg, H., and Moschen, A. R. (2008). Inflammatory mechanisms in the regulation of insulin resistance. Mol. Med. 14, 222-231.
    • (2008) Mol. Med. , vol.14 , pp. 222-231
    • Tilg, H.1    Moschen, A.R.2
  • 273
    • 80455143206 scopus 로고    scopus 로고
    • Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    • Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., Van de Weijer, T., Goossens, G. H., et al. (2011). Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 14, 612-622.
    • (2011) Cell Metab. , vol.14 , pp. 612-622
    • Timmers, S.1    Konings, E.2    Bilet, L.3    Houtkooper, R.H.4    Van de Weijer, T.5    Goossens, G.H.6
  • 274
    • 79551499779 scopus 로고    scopus 로고
    • Eicosapentaenoic acid and rosiglitazone increase adiponectin in an additive and PPAR??-dependent manner in human adipocytes
    • Tishinsky, J. M., Ma, D. W. L., and Robinson, L. E. (2011). Eicosapentaenoic acid and rosiglitazone increase adiponectin in an additive and PPAR??-dependent manner in human adipocytes. Obesity (Silver Spring) 19, 262-268.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 262-268
    • Tishinsky, J.M.1    Ma, D.W.L.2    Robinson, L.E.3
  • 275
    • 33749153435 scopus 로고    scopus 로고
    • Regulation of IL-1 and TNF receptor expression and function by endogenous macrophage migration inhibitory factor
    • Toh, M. L., Aeberli, D., Lacey, D., Yang, Y., Santos, L. L., Clarkson, M., et al. (2006). Regulation of IL-1 and TNF receptor expression and function by endogenous macrophage migration inhibitory factor. J. Immunol. 177, 4818-4825.
    • (2006) J. Immunol. , vol.177 , pp. 4818-4825
    • Toh, M.L.1    Aeberli, D.2    Lacey, D.3    Yang, Y.4    Santos, L.L.5    Clarkson, M.6
  • 276
    • 85047681877 scopus 로고    scopus 로고
    • Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines
    • Tomlinson, J. W., Moore, J., Cooper, M. S., Bujalska, I., Shahmanesh, M., Burt, C., et al. (2001). Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology 142, 1982-1989.
    • (2001) Endocrinology , vol.142 , pp. 1982-1989
    • Tomlinson, J.W.1    Moore, J.2    Cooper, M.S.3    Bujalska, I.4    Shahmanesh, M.5    Burt, C.6
  • 277
    • 79954631240 scopus 로고    scopus 로고
    • Novel immunomodulatory effects of adiponectin on dendritic cell functions
    • Tsang, J. Y. S., Li, D., Ho, D., Peng, J., Xu, A., Lamb, J., et al. (2011). Novel immunomodulatory effects of adiponectin on dendritic cell functions. Int. Immunopharmacol. 11, 604-609.
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 604-609
    • Tsang, J.Y.S.1    Li, D.2    Ho, D.3    Peng, J.4    Xu, A.5    Lamb, J.6
  • 278
    • 34547602916 scopus 로고    scopus 로고
    • Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    • Tsukumo, D. M. L., Carvalho-Filho, M. A., Carvalheira, J. B. C., Prada, P. O., Hirabara, S. M., Schenka, A. A., et al. (2007). Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56, 1986-1998.
    • (2007) Diabetes , vol.56 , pp. 1986-1998
    • Tsukumo, D.M.L.1    Carvalho-Filho, M.A.2    Carvalheira, J.B.C.3    Prada, P.O.4    Hirabara, S.M.5    Schenka, A.A.6
  • 279
    • 0242696221 scopus 로고    scopus 로고
    • Lipid overload and overflow: metabolic trauma and the metabolic syndrome
    • Unger, R. (2003). Lipid overload and overflow: metabolic trauma and the metabolic syndrome. Trends Endocrinol. Metab. 14, 398-403.
    • (2003) Trends Endocrinol. Metab. , vol.14 , pp. 398-403
    • Unger, R.1
  • 280
    • 33845490856 scopus 로고    scopus 로고
    • Review: the role of insulin resistance in nonalcoholic fatty liver disease
    • Utzschneider, K. M., and Kahn, S. E. (2006). Review: the role of insulin resistance in nonalcoholic fatty liver disease. J.Clin. Endocrinol. Metab. 91, 4753-4761.
    • (2006) J.Clin. Endocrinol. Metab. , vol.91 , pp. 4753-4761
    • Utzschneider, K.M.1    Kahn, S.E.2
  • 281
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal, K. T., Wiesbrock, S. M., Marino, M. W., and Hotamisligil, G. S. (1997). Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389, 610-614.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 282
    • 0036224269 scopus 로고    scopus 로고
    • Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes: the Leiden 85-Plus Study
    • Van Exel, E., Gussekloo, J., De Craen, A. J. M., Frölich, M., Bootsma-Van Der Wiel, A., Westendorp, R. G. J., et al. (2002). Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes: the Leiden 85-Plus Study. Diabetes 51, 1088-1092.
    • (2002) Diabetes , vol.51 , pp. 1088-1092
    • Van Exel, E.1    Gussekloo, J.2    De Craen, A.J.M.3    Frölich, M.4    Bootsma-Van Der Wiel, A.5    Westendorp, R.G.J.6
  • 284
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar, B., Youm, Y.-H. H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., et al. (2011). The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179-188.
    • (2011) Nat. Med. , vol.17 , pp. 179-188
    • Vandanmagsar, B.1    Youm, Y.-H.H.2    Ravussin, A.3    Galgani, J.E.4    Stadler, K.5    Mynatt, R.L.6
  • 285
    • 79958244231 scopus 로고    scopus 로고
    • PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation
    • Varga, T., Czimmerer, Z., and Nagy, L. (2011). PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochim. Biophys. Acta 1812, 1007-1022.
    • (2011) Biochim. Biophys. Acta , vol.1812 , pp. 1007-1022
    • Varga, T.1    Czimmerer, Z.2    Nagy, L.3
  • 286
    • 67949111187 scopus 로고    scopus 로고
    • MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease
    • Verschuren, L., Kooistra, T., Bernhagen, J., Voshol, P. J., Ouwens, D. M., Van Erk, M., et al. (2009). MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease. Circ. Res. 105, 99-107.
    • (2009) Circ. Res. , vol.105 , pp. 99-107
    • Verschuren, L.1    Kooistra, T.2    Bernhagen, J.3    Voshol, P.J.4    Ouwens, D.M.5    Van Erk, M.6
  • 289
    • 54749114466 scopus 로고    scopus 로고
    • It's not how fat you are, it's what you do with it that counts
    • doi:10.1371/journal.pbio.0060237
    • Virtue, S., and Vidal-Puig, A. (2008). It's not how fat you are, it's what you do with it that counts. PLoS Biol. 6:e237. doi:10.1371/journal.pbio.0060237
    • (2008) PLoS Biol. , vol.6
    • Virtue, S.1    Vidal-Puig, A.2
  • 290
    • 0036460731 scopus 로고    scopus 로고
    • Plasma concentrations of macrophage migration inhibitory factor are elevated in Pima Indians compared to Caucasians and are associated with insulin resistance
    • Vozarova, B., Stefan, N., Hanson, R., Lindsay, R. S., Bogardus, C., Tataranni, P. A., et al. (2002). Plasma concentrations of macrophage migration inhibitory factor are elevated in Pima Indians compared to Caucasians and are associated with insulin resistance. Diabetologia 45, 1739-1741.
    • (2002) Diabetologia , vol.45 , pp. 1739-1741
    • Vozarova, B.1    Stefan, N.2    Hanson, R.3    Lindsay, R.S.4    Bogardus, C.5    Tataranni, P.A.6
  • 291
    • 0035403205 scopus 로고    scopus 로고
    • Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
    • Vozarova, B., Weyer, C., Hanson, K., Tataranni, P. A., Bogardus, C., and Pratley, R. E. (2001). Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes. Res. 9, 414-417.
    • (2001) Obes. Res. , vol.9 , pp. 414-417
    • Vozarova, B.1    Weyer, C.2    Hanson, K.3    Tataranni, P.A.4    Bogardus, C.5    Pratley, R.E.6
  • 292
    • 17844391306 scopus 로고    scopus 로고
    • Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4
    • Weatherill, A. R., Lee, J. Y., Zhao, L., Lemay, D. G., Youn, H. S., and Hwang, D. H. (2005). Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4. J. Immunol. 174, 5390-5397.
    • (2005) J. Immunol. , vol.174 , pp. 5390-5397
    • Weatherill, A.R.1    Lee, J.Y.2    Zhao, L.3    Lemay, D.G.4    Youn, H.S.5    Hwang, D.H.6
  • 294
    • 33847796933 scopus 로고    scopus 로고
    • Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid
    • Weldon, S. M., Mullen, A. C., Loscher, C. E., Hurley, L. A., and Roche, H. M. (2007). Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid. J. Nutr. Biochem. 18, 250-258.
    • (2007) J. Nutr. Biochem. , vol.18 , pp. 250-258
    • Weldon, S.M.1    Mullen, A.C.2    Loscher, C.E.3    Hurley, L.A.4    Roche, H.M.5
  • 295
    • 79955038882 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • Wen, H., Gris, D., Lei, Y., Jha, S., Zhang, L., Huang, M. T., et al. (2011). Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat. Immunol. 12, 408-415.
    • (2011) Nat. Immunol. , vol.12 , pp. 408-415
    • Wen, H.1    Gris, D.2    Lei, Y.3    Jha, S.4    Zhang, L.5    Huang, M.T.6
  • 296
    • 44949233003 scopus 로고    scopus 로고
    • Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis
    • Wieckowska, A., Papouchado, B. G., Li, Z., Lopez, R., Zein, N. N., and Feldstein, A. E. (2008). Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am. J. Gastroenterol. 103, 1372-1379.
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 1372-1379
    • Wieckowska, A.1    Papouchado, B.G.2    Li, Z.3    Lopez, R.4    Zein, N.N.5    Feldstein, A.E.6
  • 297
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., et al. (2009a). Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 15, 921-929.
    • (2009) Nat. Med. , vol.15 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3    Truong, D.4    Tsui, H.5    Bahrami, J.6
  • 299
    • 11144244418 scopus 로고    scopus 로고
    • Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
    • Wolfrum, C., Asilmaz, E., Luca, E., Friedman, J. M., and Stoffel, M. (2004). Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature 432, 1027-1032.
    • (2004) Nature , vol.432 , pp. 1027-1032
    • Wolfrum, C.1    Asilmaz, E.2    Luca, E.3    Friedman, J.M.4    Stoffel, M.5
  • 300
    • 79957876276 scopus 로고    scopus 로고
    • A systematic review of salicylates in foods: estimated daily intake of a Scottish population
    • Wood, A., Baxter, G., Thies, F., Kyle, J., and Duthie, G. (2011). A systematic review of salicylates in foods: estimated daily intake of a Scottish population. Mol. Nutr. Food Res. 55(Suppl. 1), S7-S14.
    • (2011) Mol. Nutr. Food Res. , vol.55 , Issue.SUPPL. 1
    • Wood, A.1    Baxter, G.2    Thies, F.3    Kyle, J.4    Duthie, G.5
  • 301
    • 79953815551 scopus 로고    scopus 로고
    • Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    • Wu, D., Molofsky, A. B., Liang, H.-E., Ricardo-Gonzalez, R. R., Jouihan, H. A., Bando, J. K., et al. (2011). Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332, 243-247.
    • (2011) Science , vol.332 , pp. 243-247
    • Wu, D.1    Molofsky, A.B.2    Liang, H.-E.3    Ricardo-Gonzalez, R.R.4    Jouihan, H.A.5    Bando, J.K.6
  • 302
    • 0026034248 scopus 로고
    • Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells
    • Wu, K. K., Sanduja, R., Tsai, A. L., Ferhanoglu, B., and Loose-Mitchell, D. S. (1991). Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 88, 2384-2387.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 2384-2387
    • Wu, K.K.1    Sanduja, R.2    Tsai, A.L.3    Ferhanoglu, B.4    Loose-Mitchell, D.S.5
  • 303
    • 84864804711 scopus 로고    scopus 로고
    • GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with dietinduced obesity
    • Xu, J., Morinaga, H., Oh, D., Li, P., Chen, A., Talukdar, S., et al. (2012). GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with dietinduced obesity. J. Immunol. 189, 1992-1999.
    • (2012) J. Immunol. , vol.189 , pp. 1992-1999
    • Xu, J.1    Morinaga, H.2    Oh, D.3    Li, P.4    Chen, A.5    Talukdar, S.6
  • 305
    • 84867186758 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway
    • doi:10.1371/journal.pone.0045990
    • Xue, B., Yang, Z., Wang, X., and Shi, H. (2012). Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. PLoS ONE 7:e45990. doi:10.1371/journal.pone.0045990
    • (2012) PLoS ONE , vol.7
    • Xue, B.1    Yang, Z.2    Wang, X.3    Shi, H.4
  • 306
    • 80052681525 scopus 로고    scopus 로고
    • Potential role of NK cells in the pathogenesis of inflammatory bowel disease
    • Yadav, P. K., Chen, C., and Liu, Z. (2011). Potential role of NK cells in the pathogenesis of inflammatory bowel disease. J. Biomed. Biotechnol. 2011, 348530.
    • (2011) J. Biomed. Biotechnol. , vol.2011 , pp. 348530
    • Yadav, P.K.1    Chen, C.2    Liu, Z.3
  • 307
    • 84869046984 scopus 로고    scopus 로고
    • Conjugated linoleic acids inhibit hypoxia inducible factor-1?? stabilization under hypoxic condition in human hepatocellular carcinoma cells
    • Yamasaki, M., Nagatomo, T., Matsuyama, T., Ikeho, Y., Kato, E., Nishiyama, K., et al. (2012). Conjugated linoleic acids inhibit hypoxia inducible factor-1?? stabilization under hypoxic condition in human hepatocellular carcinoma cells. J. Oleo Sci. 496, 491-496.
    • (2012) J. Oleo Sci. , vol.496 , pp. 491-496
    • Yamasaki, M.1    Nagatomo, T.2    Matsuyama, T.3    Ikeho, Y.4    Kato, E.5    Nishiyama, K.6
  • 308
    • 0034859081 scopus 로고    scopus 로고
    • The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6
    • Yang, F., Oz, H. S., Barve, S., De Villiers, W. J., McClain, C. J., and Varilek, G. W. (2001). The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6. Mol. Pharmacol. 60, 528-533.
    • (2001) Mol. Pharmacol. , vol.60 , pp. 528-533
    • Yang, F.1    Oz, H.S.2    Barve, S.3    De Villiers, W.J.4    McClain, C.J.5    Varilek, G.W.6
  • 309
    • 84868143886 scopus 로고    scopus 로고
    • Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3)
    • doi:10.1371/journal.pone.0047493
    • Yang, Z., Hulver, M., McMillan, R. P., Cai, L., Kershaw, E. E., Yu, L., et al. (2012). Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3). PLoS ONE 7:e47493. doi:10.1371/journal.pone.0047493
    • (2012) PLoS ONE , vol.7
    • Yang, Z.1    Hulver, M.2    McMillan, R.P.3    Cai, L.4    Kershaw, E.E.5    Yu, L.6
  • 310
    • 70350328161 scopus 로고    scopus 로고
    • Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?
    • Yazbeck, R., Howarth, G. S., and Abbott, C. A. (2009). Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?. Trends Pharmacol. Sci. 30, 600-607.
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 600-607
    • Yazbeck, R.1    Howarth, G.S.2    Abbott, C.A.3
  • 311
    • 35148854599 scopus 로고    scopus 로고
    • Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    • Ye, J., Gao, Z., Yin, J., and He, Q. (2007). Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am. J. Physiol. Endocrinol. Metab. 293, E1118-E1128.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293
    • Ye, J.1    Gao, Z.2    Yin, J.3    He, Q.4
  • 312
    • 80052139636 scopus 로고    scopus 로고
    • Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans
    • Yoneshiro, T., Aita, S., Matsushita, M., Okamatsu-Ogura, Y., Kameya, T., Kawai, Y., et al. (2011). Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity (Silver Spring) 19, 1755-1760.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 1755-1760
    • Yoneshiro, T.1    Aita, S.2    Matsushita, M.3    Okamatsu-Ogura, Y.4    Kameya, T.5    Kawai, Y.6
  • 313
    • 84871445402 scopus 로고    scopus 로고
    • Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance
    • Yoshino, J., Conte, C., Fontana, L., Mittendorfer, B., Imai, S.-I., Schechtman, K. B., et al. (2012). Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab. 16, 658-664.
    • (2012) Cell Metab. , vol.16 , pp. 658-664
    • Yoshino, J.1    Conte, C.2    Fontana, L.3    Mittendorfer, B.4    Imai, S.-I.5    Schechtman, K.B.6
  • 314
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., et al. (2002). Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277, 50230-50236.
    • (2002) J. Biol. Chem. , vol.277 , pp. 50230-50236
    • Yu, C.1    Chen, Y.2    Cline, G.W.3    Zhang, D.4    Zong, H.5    Wang, Y.6
  • 315
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z. W., Karin, M., et al. (2001). Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293, 1673-1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6
  • 316
    • 0033817976 scopus 로고    scopus 로고
    • Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle
    • Zainal, T. A., Oberley, T. D., Allison, D. B., Szweda, L. I., and Weindruch, R. (2000). Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J. 14, 1825-1836.
    • (2000) FASEB J. , vol.14 , pp. 1825-1836
    • Zainal, T.A.1    Oberley, T.D.2    Allison, D.B.3    Szweda, L.I.4    Weindruch, R.5
  • 317
    • 17144412900 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids block dendritic cell activation and function independently of NF-kappaB activation
    • Zeyda, M., Säemann, M. D., Stuhlmeier, K. M., Mascher, D. G., Nowotny, P. N., Zlabinger, G. J., et al. (2005). Polyunsaturated fatty acids block dendritic cell activation and function independently of NF-kappaB activation. J. Biol. Chem. 280, 14293-14301.
    • (2005) J. Biol. Chem. , vol.280 , pp. 14293-14301
    • Zeyda, M.1    Säemann, M.D.2    Stuhlmeier, K.M.3    Mascher, D.G.4    Nowotny, P.N.5    Zlabinger, G.J.6
  • 318
    • 27644508837 scopus 로고    scopus 로고
    • Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells
    • Zhang, Q., Tang, X., Lu, Q. Y., Zhang, Z. F., Brown, J., and Le, A. D. (2005). Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells. Mol. Cancer Ther. 4, 1465-1474.
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1465-1474
    • Zhang, Q.1    Tang, X.2    Lu, Q.Y.3    Zhang, Z.F.4    Brown, J.5    Le, A.D.6
  • 319
    • 84872041568 scopus 로고    scopus 로고
    • A potential role for dendritic cell/macrophage-expressing DPP4 in obesity-induced visceral inflammation
    • Zhong, J., Rao, X., Deiuliis, J., Braunstein, Z., Narula, V., Hazey, J., et al. (2013). A potential role for dendritic cell/macrophage-expressing DPP4 in obesity-induced visceral inflammation. Diabetes 62, 149-157.
    • (2013) Diabetes , vol.62 , pp. 149-157
    • Zhong, J.1    Rao, X.2    Deiuliis, J.3    Braunstein, Z.4    Narula, V.5    Hazey, J.6
  • 320
    • 10044280324 scopus 로고    scopus 로고
    • Lysosomal glycosphingolipid recognition by NKT cells
    • Zhou, D., Mattner, J., Cantu, C., Schrantz, N., Yin, N., Gao, Y., et al. (2004). Lysosomal glycosphingolipid recognition by NKT cells. Science 306, 1786-1789.
    • (2004) Science , vol.306 , pp. 1786-1789
    • Zhou, D.1    Mattner, J.2    Cantu, C.3    Schrantz, N.4    Yin, N.5    Gao, Y.6
  • 321
    • 52649167708 scopus 로고    scopus 로고
    • CD4 T cells: fates, functions, and faults
    • Zhu, J., and Paul, W. E. (2008). CD4 T cells: fates, functions, and faults. Blood 112, 1557-1569.
    • (2008) Blood , vol.112 , pp. 1557-1569
    • Zhu, J.1    Paul, W.E.2
  • 322
    • 33644660157 scopus 로고    scopus 로고
    • Basic fibroblast growth factor (bFGF, FGF-2) potentiates leukocyte recruitment to inflammation by enhancing endothelial adhesion molecule expression
    • Zittermann, S. I., and Issekutz, A. C. (2006). Basic fibroblast growth factor (bFGF, FGF-2) potentiates leukocyte recruitment to inflammation by enhancing endothelial adhesion molecule expression. Am. J. Pathol. 168, 835-846.
    • (2006) Am. J. Pathol. , vol.168 , pp. 835-846
    • Zittermann, S.I.1    Issekutz, A.C.2
  • 323
    • 0035067539 scopus 로고    scopus 로고
    • Multilineage cells from human adipose tissue: implications for cell-based therapies
    • Zuk, P. A., Zhu, M., Mizuno, H., Huang, J., Futrell, J. W., Katz, A. J., et al. (2001). Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 7, 211-228.
    • (2001) Tissue Eng. , vol.7 , pp. 211-228
    • Zuk, P.A.1    Zhu, M.2    Mizuno, H.3    Huang, J.4    Futrell, J.W.5    Katz, A.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.