Targeting type 2 diabetes with c-glucosyl dihydrochalcones as selective sodium glucose co-transporter 2 (sglt2) inhibitors: Synthesis and biological evaluation

Journal of Medicinal Chemistry

Volumn 60, Issue 2, 2017, Pages 568-579

  Jesus, Ana R ^a,b   Vila Viçosa, Diogo ^a   Machuqueiro, Miguel ^a   Marques, Ana P ^a   Dore, Timothy M ^b   Rauter, Amélia P ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b NEW YORK UNIVERSITY ABU DHABI   (United Arab Emirates)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 (BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL] 3 (4 HYDROXYPHENYL)PROPAN 1 ONE; 1 [3 (BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL] 3 (4 METHOXYPHENYL)PROPAN 1 ONE; 1 [3 (BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL] 3 (4 METHYLPHENYL)PROPAN 1 ONE; 1 [3 (BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL] 3 (4 PROPYLOXYPHENYL)PROPAN 1 ONE; 1 [3 (BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL] 3 PHENYLPROPAN 1 ONE; 3 (4 ETHOXYPHENYL) 1 [3 (2,3,4,6 TETRA O BENZYL BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL]PROPAN 1 ONE; 3 (4 ETHOXYPHENYL) 1 [3 (BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL]PROPAN 1 ONE; 3 (4 FLUOROPHENYL) 1 [3 (2,3,4,6 TETRA O BENZYL BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL]PROPAN 1 ONE; 3 (4 FLUOROPHENYL) 1 [3 (BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL]PROPAN 1 ONE; 3 (4 METHOXYPHENYL) 1 [3 (2,3,4,6 TETRA O BENZYL BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL]PROPAN 1 ONE; 3 (4 METHYLPHENYL) 1 [3 (2,3,4,6 TETRA O BENZYL BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL]PROPAN 1 ONE; 3 (4 PROPYLOXYPHENYL) 1 [3 (2,3,4,6 TETRA O BENZYL BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL]PROPAN 1 ONE; 3 PHENYL 1 [3 (2,3,4,6 TETRA O BENZYL BETA DEXTRO GLUCOPYRANOSYL) 2,4,6 TRIHYDROXYPHENYL]PROPAN 1 ONE; CHALCONE DERIVATIVE; GLUCOSYL DIHYDROCHALCONE; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; UNCLASSIFIED DRUG; 1-PALMITOYL-2-OLEOYLPHOSPHATIDYLCHOLINE; ARTIFICIAL MEMBRANE; GLUCOSIDE; PHOSPHATIDYLCHOLINE; SLC5A1 PROTEIN, HUMAN; SLC5A2 PROTEIN, HUMAN; SODIUM GLUCOSE COTRANSPORTER 2;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; FLUORESCENCE ANALYSIS; GLUCOSE TRANSPORT; HEK293 CELL LINE; HUMAN; HUMAN CELL; IC50; NON INSULIN DEPENDENT DIABETES MELLITUS; ANTAGONISTS AND INHIBITORS; ARTIFICIAL MEMBRANE; CHEMISTRY; DIABETES MELLITUS, TYPE 2; MOLECULAR DOCKING; SYNTHESIS;

CHALCONES; DIABETES MELLITUS, TYPE 2; GLUCOSIDES; HEK293 CELLS; HUMANS; MEMBRANES, ARTIFICIAL; MOLECULAR DOCKING SIMULATION; PHOSPHATIDYLCHOLINES; SODIUM-GLUCOSE TRANSPORTER 1; SODIUM-GLUCOSE TRANSPORTER 2;

EID: 85010644658     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b01134     Document Type: Article

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