Bioavailability and antioxidant potential of rooibos flavonoids in humans following the consumption of different rooibos formulations

Food Chemistry

Volumn 128, Issue 2, 2011, Pages 338-347

  Breiter, Till ^a   Laue, Christian ^b   Kressel, Gaby ^a   Gröll, Stephanie ^b   Engelhardt, Ulrich H ^b   Hahn, Andreas ^a  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Antioxidant capacity; Aspalathin; Bioavailability; Flavonoid metabolites; Humans; LC MS; ORAC; Rooibos tea

Indexed keywords

ANTIOXIDANT CAPACITY; ASPALATHIN; BIOAVAILABILITY; FLAVONOID METABOLITES; HUMANS; LC/MS; ORAC; ROOIBOS TEA;

BEVERAGES; BIOCHEMISTRY; BIOMOLECULES; BODY FLUIDS; METABOLISM;

METABOLITES;

ASPALATHIN; FLAVONOID; NOTHOFAGIN; UNCLASSIFIED DRUG;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; ASPALATHUS LINEARIS; BIOAVAILABILITY; BLOOD SAMPLING; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGHER PLANT; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; METABOLITE; METHYLATION; NORMAL HUMAN; ROOIBOS; TEA; URINALYSIS;

ASPALATHUS LINEARIS;

EID: 79955618009     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2011.03.029     Document Type: Article

References (26)

1. Arts, M. J. T. J., Haenen, G. R. M. M., Voss, H.-P., & Bast, A. (2001). Masking of antioxidant capacity by the interaction of flavonoids with protein. Food and Chemical Toxicology, 39, 787-791. (Pubitemid 32575245)
2. Arts, I. C., & Hollman, P. C. (2005). Polyphenols and disease risk in epidemiologic studies. American Journal of Clinical Nutrition, 81, 317S-325S.
3. Courts, F. L., & Williamson, G. (2009). The C-glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans. Molecular Nutrition and Food Research, 53, 1104-1111.
4. Dávalos, A., Gómez-Cordovés, C., & Bartolomé, B. (2004). Extending applicability of the oxygen radical absorbance capacity (ORAC-fluorescein) assay. Journal of Agricultural and Food Chemistry, 52, 48-54.
5. Ferreres, F., Silva, B. M., Andrade, P. M., Seabra, R. M., & Ferreira, M. A. (2003). Approach to the study of C-glycosyl flavones by ion trap HPLC-PAD-ESI/MS/MS: Application to seeds of Quince (Cydonia oblonga). Phytochemical Analysis, 14, 352-359.
6. Figueirinha, A., Paranhos, A., Pérez-Alonso, J. J., Santos-Buelga, C., & Batista, M. T. (2008). Cymbopogon citratus leaves: Characterization of flavonoids by HPLC-PDA-ESI/MS/MS and an approach to their potential as a source of bioactive polyphenols. Food Chemistry, 110, 718-728.
7. Joubert, E., Winterton, P., Britz, T. J., & Gelderblom, W. C. A. (2005). Antioxidant and pro-oxidant activities of aqueous extracts and crude polyphenolic fractions of rooibos (Aspalathus linearis). Journal of Agricultural and Food Chemistry, 53, 10260-10267. (Pubitemid 43081245)
8. Knekt, P., Kumpulainen, J., Järvinen, R., Rissanen, H., Heliövaara, M., Reunanen, A., et al. (2002). Flavonoid intake and risk of chronic diseases. American Journal of Clinical Nutrition, 76, 560-568. (Pubitemid 34920833)
9. Krafczyk, N., & Glomb, M. A. (2008). Characterization of phenolic compounds in rooibos tea. Journal of Agricultural and Food Chemistry, 56, 3368-3376. (Pubitemid 351746069)
10. Kreuz, S., Joubert, E., Waldmann, K.-H., & Ternes, W. (2008). Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside. Nutrition Research, 28, 690-701.
11. Laue, C., Gröll, S., Breiter, T., & Engelhardt, U. H. (2010). Bioverfügbarkeit von Flavonoiden aus grünem Rooibos. Lebensmittelchemie, 64, 121-122.
12. Lotito, S. B., & Frei, B. (2006). Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon? Free Radical Biology and Medicine, 41, 1727-1746.
13. Manach, C., Morand, C., Texier, O., Favier, M.-L., Agullo, G., Demigné, C., et al. (1995). Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin. Journal of Nutrition, 125, 1911-1922.
14. Marais, C., van Rensburg, W. J., Ferreira, D., & Steenkamp, J. A. (2000). (S)- and (R)- Eriodictyol-6-C-β-D-glucopyranoside, novel keys to the fermentation of rooibos (Aspalathus linearis. Phytochemistry, 55, 43-49.
15. Maron, D. J. (2004). Flavonoids for reduction of atherosclerotic risk. Current Atherosclerosis Reports, 6, 73-78.
16. Nikolova, V., Petrova, S., Petkova, V., Pavlova, S., Michailova, A., & Georgieva, T. (2007). Antioxidant effects of rooibos tea on workers occupationally exposed lo lead. Toxicology Letters, 172, S120-S121.
17. Piccinelli, A. L., Garcia Mesa, M., Armenteros, D. M., Alfonso, M. A., Arevalo, A. C., Campone, L., et al. (2008). HPLC-PDA-MS and NMR characterization of C-glycosyl flavones in a hydroalcoholic extract of Citrus aurantifolia leaves with antiplatelet activity. Journal of Agricultural and Food Chemistry, 56, 1574-1581. (Pubitemid 351506865)
18. Prior, R. L., Gu, L., Wu, X., Jacob, R. A., Sotoudeh, G., Kader, A. A., et al. (2007). Plasma antioxidant capacity changes following a meal as a measure of the ability of a food to alter in vivo antioxidant status. Journal of the American College of Nutrition, 26, 170-181. (Pubitemid 46911261)
19. Rietveld, A., & Wiseman, S. (2003). Antioxidant effects of tea: Evidence from human clinical trials. Journal of Nutrition, 133, 3285S-3292S.
20. Sanugul, K., Akao, T., Li, Y., Kakiuchi, N., Nakamura, N., & Hattori, M. (2005). Isolation of a human intestinal bacterium that transforms mangiferin to norathyriol and inducibility of the enzyme that cleaves a C-glucosyl bond. Biological and Pharmaceutical Bulletin, 28, 1672-1678.
21. Sauter, W. (2004). Vergleich antioxidativer Eigenschaften von Extrakten aus Camellia sinensis, Rosmarinus officinalis, Cyclopia genistoides, Cyclopia sessiliflora und Aspalathus linearis. Ph.D. Dissertation. Technische Universität München. Weihenstephan, Germany.
22. Snijman, P. W., Joubert, E., Ferreira, D., Li, X.-C., Ding, Y., Green, I. R., et al. (2009). Antioxidant activity of the dihydrochalcones aspalathin and nothofagin and their corresponding flavones in relation to other rooibos (Aspalathus linearis) flavonoids, epigallocatechin gallate, and Trolox. Journal of Agricultural and Food Chemistry, 57, 6678-6684.
23. Stalmach, A., Mullen, W., Pecorari, M., Serafini, M., & Crozier, A. (2009). Bioavailability of C-linked dihydrochalcone and flavanone glucosides in humans following ingestion of unfermented and fermented rooibos teas. Journal of Agricultural and Food Chemistry, 57, 7104-7111.
24. Standley, L., Winterton, P., Marnewick, J. L., Gelderblom, W. C. A., Joubert, E., & Britz, T. J. (2001). Influence of processing stages on antimutagenic and antioxidant potentials of rooibos tea. Journal of Agricultural and Food Chemistry, 49, 114-117.
25. Villaño, D., Pecorari, M., Testa, M. F., Raguzzini, A., Stalmach, A., Crozier, A., et al. (2010). Unfermented and fermented rooibos teas (Aspalathus linearis) increase plasma total antioxidant capacity in healthy humans. Food Chemistry, 123, 679-683.
26. Zhang, Y., Tie, X., Bao, B., Wu, X., & Zhang, Y. (2007). Metabolism of flavone Cglucosides and p-coumaric acid from antioxidant of bamboo leaves (AOB) in rats. British Journal of Nutrition, 97, 484-494.