메뉴 건너뛰기




Volumn 22, Issue 1, 2017, Pages

Aspalathin protects the heart against hyperglycemia-induced oxidative damage by up-regulating Nrf2 expression

Author keywords

Aspalathin; Cardiomyopathy; Diabetes mellitus; Hyperglycemia; Nrf2; Oxidative stress

Indexed keywords

ASPALATHIN; CARDIOTONIC AGENT; CHALCONE DERIVATIVE; GLUCOSE; NFE2L2 PROTEIN, MOUSE; NFE2L2 PROTEIN, RAT; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2;

EID: 85009775786     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules22010129     Document Type: Article
Times cited : (70)

References (54)
  • 1
    • 84874585944 scopus 로고    scopus 로고
    • International Diabetes Federation (IDF). 7th ed. (accessed on 20 February 2016)
    • International Diabetes Federation (IDF). IDF Diabetes Atlas, 7th ed. Available online: http://www.diabetesatlas.org/ (accessed on 20 February 2016).
    • IDF Diabetes Atlas
  • 2
    • 42349087252 scopus 로고    scopus 로고
    • Microvascular and macrovascular complications of diabetes
    • [CrossRef]
    • Fowler, M.J. Microvascular and macrovascular complications of diabetes. Clin. Diabetes 2008, 26, 77-82. [CrossRef]
    • (2008) Clin. Diabetes , vol.26 , pp. 77-82
    • Fowler, M.J.1
  • 3
    • 84919999219 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • [CrossRef] [PubMed]
    • Inzucchi, S.E.; Bergenstal, R.M.; Buse, J.B.; Diamant, M.; Ferrannini, E.; Nauck, M.; Peters, A.L.; Tsapas, A.; Wender, R.; Matthews, D.R. Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2015, 38, 140-149. [CrossRef] [PubMed]
    • (2015) Diabetes Care , vol.38 , pp. 140-149
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3    Diamant, M.4    Ferrannini, E.5    Nauck, M.6    Peters, A.L.7    Tsapas, A.8    Wender, R.9    Matthews, D.R.10
  • 5
    • 23744487440 scopus 로고    scopus 로고
    • An approach to heart failure and diabetes mellitus
    • [CrossRef] [PubMed]
    • Fonarow, G.C. An approach to heart failure and diabetes mellitus. Am. J. Cardiol. 2005, 96, 47-52. [CrossRef] [PubMed]
    • (2005) Am. J. Cardiol. , vol.96 , pp. 47-52
    • Fonarow, G.C.1
  • 6
    • 77953440109 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy, causes and effects
    • [CrossRef] [PubMed]
    • Boudina, S.; Abel, E.D. Diabetic cardiomyopathy, causes and effects. Rev. Endocr. Metab. Disord. 2010, 11, 31-39. [CrossRef] [PubMed]
    • (2010) Rev. Endocr. Metab. Disord. , vol.11 , pp. 31-39
    • Boudina, S.1    Abel, E.D.2
  • 7
    • 84902302491 scopus 로고    scopus 로고
    • Taking diabetes to heart-deregulation of myocardial lipid metabolism in diabetic cardiomyopathy
    • [CrossRef] [PubMed]
    • Bayeva, M.; Sawicki, K.T.; Ardehali, H. Taking diabetes to heart-deregulation of myocardial lipid metabolism in diabetic cardiomyopathy. J. Am. Heart Assoc. 2013, 2, e000433. [CrossRef] [PubMed]
    • (2013) J. Am. Heart Assoc. , vol.2 , pp. e000433
    • Bayeva, M.1    Sawicki, K.T.2    Ardehali, H.3
  • 8
    • 0035749812 scopus 로고    scopus 로고
    • Oxidative stress and diabetic cardiomyopathy: A brief review
    • [CrossRef] [PubMed]
    • Cai, L.; Kang, Y.J. Oxidative stress and diabetic cardiomyopathy: A brief review. Cardiovasc. Toxicol. 2001, 1, 181-193. [CrossRef] [PubMed]
    • (2001) Cardiovasc. Toxicol. , vol.1 , pp. 181-193
    • Cai, L.1    Kang, Y.J.2
  • 9
    • 83755186736 scopus 로고    scopus 로고
    • Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodelling process via modulation of MAPK/NF-B signaling pathways after streptozotocin-induced diabetes mellitus
    • [CrossRef] [PubMed]
    • Thandavarayan, R.A.; Giridharan, V.V.; Sari, F.R.; Arumugam, S.; Veeraveedu, P.T.; Pandian, G.N.; Palaniyandi, S.S.; Ma, M.; Suzuki, K.; Gurusamy, N.; et al. Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodelling process via modulation of MAPK/NF-B signaling pathways after streptozotocin-induced diabetes mellitus. Cell. Physiol. Biochem. 2011, 28, 911-922. [CrossRef] [PubMed]
    • (2011) Cell. Physiol. Biochem. , vol.28 , pp. 911-922
    • Thandavarayan, R.A.1    Giridharan, V.V.2    Sari, F.R.3    Arumugam, S.4    Veeraveedu, P.T.5    Pandian, G.N.6    Palaniyandi, S.S.7    Ma, M.8    Suzuki, K.9    Gurusamy, N.10
  • 10
    • 84958719896 scopus 로고    scopus 로고
    • Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats
    • [CrossRef] [PubMed]
    • Liu, H.; Liu, H.Y.; Jiang, Y.N.; Li, N. Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats. Mol. Med. Rep. 2016, 13, 2836-2842. [CrossRef] [PubMed]
    • (2016) Mol. Med. Rep. , vol.13 , pp. 2836-2842
    • Liu, H.1    Liu, H.Y.2    Jiang, Y.N.3    Li, N.4
  • 11
    • 84877734956 scopus 로고    scopus 로고
    • Nuclear factor (erythroid-derived 2)-like-2 factor (Nrf2), a key regulator of the antioxidant response to protect against atherosclerosis and nonalcoholic steatohepatitis
    • [CrossRef] [PubMed]
    • Gupte, A.A.; Lyon, C.J.; Hsueh, W.A. Nuclear factor (erythroid-derived 2)-like-2 factor (Nrf2), a key regulator of the antioxidant response to protect against atherosclerosis and nonalcoholic steatohepatitis. Curr. Diabetes Rep. 2013, 13, 362-371. [CrossRef] [PubMed]
    • (2013) Curr. Diabetes Rep. , vol.13 , pp. 362-371
    • Gupte, A.A.1    Lyon, C.J.2    Hsueh, W.A.3
  • 12
    • 84969983910 scopus 로고    scopus 로고
    • The emerging role of Nrf2 in mitochondrial function
    • [CrossRef] [PubMed]
    • Dinkova-Kostova, A.T.; Abramov, A.Y. The emerging role of Nrf2 in mitochondrial function. Free Radic. Biol. Med. 2015, 88, 179-188. [CrossRef] [PubMed]
    • (2015) Free Radic. Biol. Med. , vol.88 , pp. 179-188
    • Dinkova-Kostova, A.T.1    Abramov, A.Y.2
  • 13
    • 57249104720 scopus 로고    scopus 로고
    • Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes
    • [CrossRef] [PubMed]
    • He, X.; Kan, H.; Cai, L.; Ma, Q. Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes. J. Mol. Cell. Cardiol. 2009, 46, 47-58. [CrossRef] [PubMed]
    • (2009) J. Mol. Cell. Cardiol. , vol.46 , pp. 47-58
    • He, X.1    Kan, H.2    Cai, L.3    Ma, Q.4
  • 14
    • 79551575483 scopus 로고    scopus 로고
    • Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo
    • [CrossRef] [PubMed]
    • Tan, Y.; Ichikawa, T.; Li, J.; Si, Q.; Yang, H.; Chen, X.; Goldblatt, C.S.; Meyer, C.J.; Li, X.; Cai, L.; et al. Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo. Diabetes 2011, 60, 625-633. [CrossRef] [PubMed]
    • (2011) Diabetes , vol.60 , pp. 625-633
    • Tan, Y.1    Ichikawa, T.2    Li, J.3    Si, Q.4    Yang, H.5    Chen, X.6    Goldblatt, C.S.7    Meyer, C.J.8    Li, X.9    Cai, L.10
  • 15
    • 84927915781 scopus 로고    scopus 로고
    • Resveratrol protects againstmethylglyoxal-induced hyperglycemia and pancreatic damage in vivo
    • [CrossRef] [PubMed]
    • Cheng,A.S.; Cheng, Y.H.; Lee, C.Y.; Chung, C.Y.; Chang,W.C. Resveratrol protects againstmethylglyoxal-induced hyperglycemia and pancreatic damage in vivo. Nutrients 2015, 7, 2850-2865. [CrossRef] [PubMed]
    • (2015) Nutrients , vol.7 , pp. 2850-2865
    • Cheng, A.S.1    Cheng, Y.H.2    Lee, C.Y.3    Chung, C.Y.4    Chang, W.C.5
  • 16
    • 84876915208 scopus 로고    scopus 로고
    • Sulforaphane protects against ethanol-induced oxidative stress and apoptosis in neural crest cells by the induction of Nrf2-mediated antioxidant response
    • [CrossRef] [PubMed]
    • Chen, X.; Liu, J.; Chen, S.Y. Sulforaphane protects against ethanol-induced oxidative stress and apoptosis in neural crest cells by the induction of Nrf2-mediated antioxidant response. Br. J. Pharmacol. 2013, 169, 437-448. [CrossRef] [PubMed]
    • (2013) Br. J. Pharmacol. , vol.169 , pp. 437-448
    • Chen, X.1    Liu, J.2    Chen, S.Y.3
  • 17
    • 84908886512 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy and its prevention by Nrf2: Current status
    • [CrossRef] [PubMed]
    • Chen, J.; Zhang, Z.; Cai, L. Diabetic cardiomyopathy and its prevention by Nrf2: Current status. Diabetes Metab. J. 2014, 38, 337-345. [CrossRef] [PubMed]
    • (2014) Diabetes Metab. J. , vol.38 , pp. 337-345
    • Chen, J.1    Zhang, Z.2    Cai, L.3
  • 18
    • 84873737258 scopus 로고    scopus 로고
    • Prevention by sulforaphane of diabetic cardiomyopathy is associated with upregulation of Nrf2 expression and transcription activation
    • [CrossRef] [PubMed]
    • Bai, Y.; Cui, W.; Xin, Y.; Miao, X.; Barati, M.T.; Zhang, C.; Chen, Q.; Tan, Y.; Cui, T.; Zheng, Y.; et al. Prevention by sulforaphane of diabetic cardiomyopathy is associated with upregulation of Nrf2 expression and transcription activation. J. Mol. Cell. Cardiol. 2013, 57, 82-95. [CrossRef] [PubMed]
    • (2013) J. Mol. Cell. Cardiol. , vol.57 , pp. 82-95
    • Bai, Y.1    Cui, W.2    Xin, Y.3    Miao, X.4    Barati, M.T.5    Zhang, C.6    Chen, Q.7    Tan, Y.8    Cui, T.9    Zheng, Y.10
  • 19
    • 84855833029 scopus 로고    scopus 로고
    • Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38
    • [CrossRef] [PubMed]
    • Granado-Serrano, A.B.; Martín, M.A.; Bravo, L.; Goya, L.; Ramos, S. Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. Chem. Biol. Interact. 2012, 195, 154-164. [CrossRef] [PubMed]
    • (2012) Chem. Biol. Interact. , vol.195 , pp. 154-164
    • Granado-Serrano, A.B.1    Martín, M.A.2    Bravo, L.3    Goya, L.4    Ramos, S.5
  • 20
    • 84870902532 scopus 로고    scopus 로고
    • Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
    • [CrossRef] [PubMed]
    • Zhang, M.; An, C.; Gao, Y.; Leak, R.K.; Chen, J.; Zhang, F. Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection. Prog. Neurobiol. 2013, 100, 30-47. [CrossRef] [PubMed]
    • (2013) Prog. Neurobiol. , vol.100 , pp. 30-47
    • Zhang, M.1    An, C.2    Gao, Y.3    Leak, R.K.4    Chen, J.5    Zhang, F.6
  • 21
    • 84870428902 scopus 로고    scopus 로고
    • Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential
    • [CrossRef] [PubMed]
    • Muller, C.J.; Joubert, E.; de Beer, D.; Sanderson, M.; Malherbe, C.J.; Fey, S.J.; Louw, J. Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential. Phytomedicine 2012, 20, 32-39. [CrossRef] [PubMed]
    • (2012) Phytomedicine , vol.20 , pp. 32-39
    • Muller, C.J.1    Joubert, E.2    De Beer, D.3    Sanderson, M.4    Malherbe, C.J.5    Fey, S.J.6    Louw, J.7
  • 22
    • 84879885429 scopus 로고    scopus 로고
    • Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis)
    • [CrossRef] [PubMed]
    • Mazibuko, S.E.; Muller, C.J.; Joubert, E.; de Beer, D.; Johnson, R.; Opoku, A.R.; Louw, J. Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis). Phytomedicine 2013, 20, 813-819. [CrossRef] [PubMed]
    • (2013) Phytomedicine , vol.20 , pp. 813-819
    • Mazibuko, S.E.1    Muller, C.J.2    Joubert, E.3    De Beer, D.4    Johnson, R.5    Opoku, A.R.6    Louw, J.7
  • 23
    • 84898057712 scopus 로고    scopus 로고
    • The cardioprotective effect of an aqueous extract of fermented rooibos (Aspalathus linearis) on cultured cardiomyocytes derived from diabetic rats
    • [CrossRef] [PubMed]
    • Dludla, P.V.; Muller, C.J.; Louw, J.; Joubert, E.; Salie, R.; Opoku, A.R.; Johnson, R. The cardioprotective effect of an aqueous extract of fermented rooibos (Aspalathus linearis) on cultured cardiomyocytes derived from diabetic rats. Phytomedicine 2014, 21, 595-601. [CrossRef] [PubMed]
    • (2014) Phytomedicine , vol.21 , pp. 595-601
    • Dludla, P.V.1    Muller, C.J.2    Louw, J.3    Joubert, E.4    Salie, R.5    Opoku, A.R.6    Johnson, R.7
  • 25
    • 84889018108 scopus 로고    scopus 로고
    • Z-2-(-D-glucopyranosyloxy)-3-phenylpropenoic acid, an-hydroxy acid from rooibos (Aspalathus linearis) with hypoglycemic activity
    • [CrossRef] [PubMed]
    • Muller, C.J.; Joubert, E.; Pheiffer, C.; Ghoor, S.; Sanderson, M.; Chellan, N.; Fey, S.J.; Louw, J. Z-2-(-D-glucopyranosyloxy)-3-phenylpropenoic acid, an-hydroxy acid from rooibos (Aspalathus linearis) with hypoglycemic activity. Mol. Nutr. Food Res. 2013, 57, 2216-2222. [CrossRef] [PubMed]
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 2216-2222
    • Muller, C.J.1    Joubert, E.2    Pheiffer, C.3    Ghoor, S.4    Sanderson, M.5    Chellan, N.6    Fey, S.J.7    Louw, J.8
  • 26
    • 84941710120 scopus 로고    scopus 로고
    • Aspalathin improves glucose and lipid metabolism in 3T3-L1 adipocytes exposed to palmitate
    • [CrossRef] [PubMed]
    • Mazibuko, S.E.; Joubert, E.; Johnson, R.; Louw, J.; Opoku, A.R.; Muller, C.J. Aspalathin improves glucose and lipid metabolism in 3T3-L1 adipocytes exposed to palmitate. Mol. Nutr. Food Res. 2015, 59, 2199-2208. [CrossRef] [PubMed]
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 2199-2208
    • Mazibuko, S.E.1    Joubert, E.2    Johnson, R.3    Louw, J.4    Opoku, A.R.5    Muller, C.J.6
  • 27
    • 0000956196 scopus 로고    scopus 로고
    • Comparison of the antioxidant activity of aspalathin with that of other plant phenols of rooibos tea (Aspalathus linearis), tocopherol, BHT, and BHA
    • [CrossRef]
    • Von Gadow, A.; Joubert, E.; Hansmann, C.F. Comparison of the antioxidant activity of aspalathin with that of other plant phenols of rooibos tea (Aspalathus linearis), -tocopherol, BHT, and BHA. J. Agric. Food Chem. 1997, 45, 632-638. [CrossRef]
    • (1997) J. Agric. Food Chem. , vol.45 , pp. 632-638
    • Von Gadow, A.1    Joubert, E.2    Hansmann, C.F.3
  • 28
    • 68249084032 scopus 로고    scopus 로고
    • Antioxidant activity of the dihydrochalcones aspalathin and nothofagin and their corresponding flavones in relation to other rooibos (Aspalathus linearis) flavonoids, epigallocatechin gallate, and trolox
    • [CrossRef] [PubMed]
    • Snijman, P.W.; Joubert, E.; Ferreira, D.; Li, X.C.; Ding, Y.; Green, I.R.; Gelderblom,W.C. Antioxidant activity of the dihydrochalcones aspalathin and nothofagin and their corresponding flavones in relation to other rooibos (Aspalathus linearis) flavonoids, epigallocatechin gallate, and trolox. J. Agric. Food Chem. 2009, 57, 6678-6684. [CrossRef] [PubMed]
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 6678-6684
    • Snijman, P.W.1    Joubert, E.2    Ferreira, D.3    Li, X.C.4    Ding, Y.5    Green, I.R.6    Gelderblom, W.C.7
  • 29
    • 67649083956 scopus 로고    scopus 로고
    • Structure-antioxidant relationship of flavonoids from fermented rooibos
    • [CrossRef] [PubMed]
    • Krafczyk, N.; Woyand, F.; Glomb, M.A. Structure-antioxidant relationship of flavonoids from fermented rooibos. Mol. Nutr. Food Res. 2009, 53, 635-642. [CrossRef] [PubMed]
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 635-642
    • Krafczyk, N.1    Woyand, F.2    Glomb, M.A.3
  • 30
    • 64449086955 scopus 로고    scopus 로고
    • Hypoglycemic effect of aspalathin a rooibos tea component from Aspalathus linearis in type 2 diabetic model db/db mice
    • [CrossRef] [PubMed]
    • Kawano, A.; Nakamura, H.; Hata, S.;Minakawa,M.;Miura, Y.; Yagasaki, K. Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice. Phytomedicine 2009, 16, 437-443. [CrossRef] [PubMed]
    • (2009) Phytomedicine , vol.16 , pp. 437-443
    • Kawano, A.1    Nakamura, H.2    Hata, S.3    Minakawa, M.4    Miura, Y.5    Yagasaki, K.6
  • 31
    • 84891836160 scopus 로고    scopus 로고
    • Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice
    • [CrossRef] [PubMed]
    • Son, M.J.; Minakawa, M.; Miura, Y.; Yagasaki, K. Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice. Eur. J. Nutr. 2013, 52, 1607-1619. [CrossRef] [PubMed]
    • (2013) Eur. J. Nutr. , vol.52 , pp. 1607-1619
    • Son, M.J.1    Minakawa, M.2    Miura, Y.3    Yagasaki, K.4
  • 32
    • 84962693099 scopus 로고    scopus 로고
    • Aspalathin a dihydrochalcone C-glucoside, protects H9c2 cardiomyocytes against high glucose-induced shifts in substrate preference and apoptosis
    • [CrossRef] [PubMed]
    • Johnson, R.; Dludla, P.; Joubert, E.; February, F.; Mazibuko, S.; Ghoor, S.; Muller, C.; Louw, J. Aspalathin, a dihydrochalcone C-glucoside, protects H9c2 cardiomyocytes against high glucose-induced shifts in substrate preference and apoptosis. Mol. Nutr. Food Res. 2016, 60, 922-934. [CrossRef] [PubMed]
    • (2016) Mol. Nutr. Food Res. , vol.60 , pp. 922-934
    • Johnson, R.1    Dludla, P.2    Joubert, E.3    February, F.4    Mazibuko, S.5    Ghoor, S.6    Muller, C.7    Louw, J.8
  • 33
    • 84969857864 scopus 로고    scopus 로고
    • Activated AMPK boosts the Nrf2/HO-1 signaling axis-A role for the unfolded protein response
    • [CrossRef] [PubMed]
    • Zimmermann, K.; Baldinger, J.; Mayerhofer, B.; Atanasov, A.G.; Dirsch, V.M.; Heiss, E.H. Activated AMPK boosts the Nrf2/HO-1 signaling axis-A role for the unfolded protein response. Free Radic. Biol. Med. 2015, 88, 417-426. [CrossRef] [PubMed]
    • (2015) Free Radic. Biol. Med. , vol.88 , pp. 417-426
    • Zimmermann, K.1    Baldinger, J.2    Mayerhofer, B.3    Atanasov, A.G.4    Dirsch, V.M.5    Heiss, E.H.6
  • 34
    • 84962892170 scopus 로고    scopus 로고
    • Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators
    • [CrossRef] [PubMed]
    • Zhu, Y.; Wang, P.; Zhao, Y.; Yang, C.; Clark, A.; Leung, T.; Chen, X.; Sang, S. Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators. Free Radic. Biol. Med. 2016, 95, 243-254. [CrossRef] [PubMed]
    • (2016) Free Radic. Biol. Med. , vol.95 , pp. 243-254
    • Zhu, Y.1    Wang, P.2    Zhao, Y.3    Yang, C.4    Clark, A.5    Leung, T.6    Chen, X.7    Sang, S.8
  • 35
    • 84935862032 scopus 로고    scopus 로고
    • Neohesperidin dihydrochalcone versus CCl-induced hepatic injury through different mechanisms: The implication of free radical scavenging and Nrf2 activation
    • [CrossRef] [PubMed]
    • Su, C.; Xia, X.; Shi, Q.; Song, X.; Fu, J.; Xiao, C.; Chen, H.; Lu, B.; Sun, Z.; Wu, S.; et al. Neohesperidin dihydrochalcone versus CCl-induced hepatic injury through different mechanisms: the implication of free radical scavenging and Nrf2 activation. J. Agric. Food Chem. 2015, 63, 5468-5475. [CrossRef] [PubMed]
    • (2015) J. Agric. Food Chem. , vol.63 , pp. 5468-5475
    • Su, C.1    Xia, X.2    Shi, Q.3    Song, X.4    Fu, J.5    Xiao, C.6    Chen, H.7    Lu, B.8    Sun, Z.9    Wu, S.10
  • 36
    • 78349297565 scopus 로고    scopus 로고
    • Oxidative stress and diabetic complications
    • [CrossRef] [PubMed]
    • Giacco, F.; Brownlee, M. Oxidative stress and diabetic complications. Circ. Res. 2010, 107, 1058-1070. [CrossRef] [PubMed]
    • (2010) Circ. Res. , vol.107 , pp. 1058-1070
    • Giacco, F.1    Brownlee, M.2
  • 38
    • 0036828726 scopus 로고    scopus 로고
    • Relative contributions of heart mitochondrial glutathione peroxidase and catalase to H2O2 detoxification in in vivo conditions
    • [CrossRef]
    • Antunes, F.; Han, D.; Cadenas, E. Relative contributions of heart mitochondrial glutathione peroxidase and catalase to H2O2 detoxification in in vivo conditions. Free Radic. Biol. Med. 2002, 33, 1260-1267. [CrossRef]
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 1260-1267
    • Antunes, F.1    Han, D.2    Cadenas, E.3
  • 39
    • 84930927332 scopus 로고    scopus 로고
    • Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: Role of AMP-activated protein kinase activation
    • [CrossRef] [PubMed]
    • Zheng, A.; Li, H.; Xu, J.; Cao, K.; Li, H.; Pu, W.; Yang, Z.; Peng, Y.; Long, J.; Liu, J.; et al. Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: Role of AMP-activated protein kinase activation. Br. J. Nutr. 2015, 113, 1667-1676. [CrossRef] [PubMed]
    • (2015) Br. J. Nutr. , vol.113 , pp. 1667-1676
    • Zheng, A.1    Li, H.2    Xu, J.3    Cao, K.4    Li, H.5    Pu, W.6    Yang, Z.7    Peng, Y.8    Long, J.9    Liu, J.10
  • 40
    • 85009808046 scopus 로고    scopus 로고
    • Type 2 diabetic cardiomyopathy in db/db mice is associated with progressive cardiac fibrosis, cardiomyocyte hypertrophy and oxidative stress
    • [CrossRef]
    • Ritchie, R.; Julius, T.; Buxton, K.; Xu, Q.; Kiriazis, H.; McMullen, J.; Forbes, J.; Du, X.; Kaye, D.; Tesch, G. Type 2 diabetic cardiomyopathy in db/db mice is associated with progressive cardiac fibrosis, cardiomyocyte hypertrophy and oxidative stress. Heart Lung Circ. 2008, 17, S231. [CrossRef]
    • (2008) Heart Lung Circ. , vol.17 , pp. S231
    • Ritchie, R.1    Julius, T.2    Buxton, K.3    Xu, Q.4    Kiriazis, H.5    McMullen, J.6    Forbes, J.7    Du, X.8    Kaye, D.9    Tesch, G.10
  • 41
    • 0033662461 scopus 로고    scopus 로고
    • Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice
    • [PubMed]
    • Belke, D.D.; Larsen, T.S.; Gibbs, E.M.; Severson, D.L. Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. Am. J. Physiol. Endocrinol. Metab. 2000, 279, E1104-E1113. [PubMed]
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.279 , pp. E1104-E1113
    • Belke, D.D.1    Larsen, T.S.2    Gibbs, E.M.3    Severson, D.L.4
  • 42
    • 84901592899 scopus 로고    scopus 로고
    • The detrimental effects of acute hyperglycemia on myocardial glucose uptake
    • [CrossRef] [PubMed]
    • Joseph, D.; Kimar, C.; Symington, B.; Milne, R.; Essop, M.F. The detrimental effects of acute hyperglycemia on myocardial glucose uptake. Life Sci. 2014, 105, 31-42. [CrossRef] [PubMed]
    • (2014) Life Sci. , vol.105 , pp. 31-42
    • Joseph, D.1    Kimar, C.2    Symington, B.3    Milne, R.4    Essop, M.F.5
  • 43
    • 84954508083 scopus 로고    scopus 로고
    • Damaging effects of hyperglycemia on cardiovascular function: Spotlight on glucose metabolic pathways
    • [CrossRef] [PubMed]
    • Mapanga, R.F.; Essop, M.F. Damaging effects of hyperglycemia on cardiovascular function: Spotlight on glucose metabolic pathways. Am. J. Physiol. Heart Circ. Physiol. 2016, 310, H153-H173. [CrossRef] [PubMed]
    • (2016) Am. J. Physiol. Heart Circ. Physiol. , vol.310 , pp. H153-H173
    • Mapanga, R.F.1    Essop, M.F.2
  • 44
    • 84878003949 scopus 로고    scopus 로고
    • The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress
    • [CrossRef] [PubMed]
    • Anedda, A.; López-Bernardo, E.; Acosta-Iborra, B.; Saadeh Suleiman, M.; Landázuri, M.O.; Cadenas, S. The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress. Free Radic. Biol. Med. 2013, 61, 395-407. [CrossRef] [PubMed]
    • (2013) Free Radic. Biol. Med. , vol.61 , pp. 395-407
    • Anedda, A.1    López-Bernardo, E.2    Acosta-Iborra, B.3    Saadeh Suleiman, M.4    Landázuri, M.O.5    Cadenas, S.6
  • 45
    • 84893196378 scopus 로고    scopus 로고
    • New insights into the mechanisms of polyphenols beyond antioxidant properties; Lessons from the green tea polyphenol, epigallocatechin 3-gallate
    • [CrossRef] [PubMed]
    • Kim, H.S.; Quon, M.J.; Kim, J.A. New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate. Redox Biol. 2014, 2, 187-195. [CrossRef] [PubMed]
    • (2014) Redox Biol. , vol.2 , pp. 187-195
    • Kim, H.S.1    Quon, M.J.2    Kim, J.A.3
  • 46
    • 84882337020 scopus 로고    scopus 로고
    • P-value a true test of statistical significance? A cautionary note
    • [CrossRef] [PubMed]
    • Dahiru, T. P-value, a true test of statistical significance? A cautionary note. Ann. Ib. Postgrad. Med. 2008, 6, 21-26. [CrossRef] [PubMed]
    • (2008) Ann. Ib. Postgrad. Med. , vol.6 , pp. 21-26
    • Dahiru, T.1
  • 47
    • 69049110950 scopus 로고    scopus 로고
    • Confidence interval or p-value? Part 4 of a series on evaluation of scientific publications
    • Du Prel, J.B.; Hommel, G.; Rohrig, B.; Blettner, M. Confidence interval or p-value? Part 4 of a series on evaluation of scientific publications. Dtsch. Arzteblatt Int. 2009, 106, 335-339.
    • (2009) Dtsch. Arzteblatt Int. , vol.106 , pp. 335-339
    • Du Prel, J.B.1    Hommel, G.2    Rohrig, B.3    Blettner, M.4
  • 48
    • 84978529130 scopus 로고    scopus 로고
    • Phenylpyruvic acid-2-O-D-glucoside attenuates high glucose-induced apoptosis in H9c2 cardiomyocytes
    • [CrossRef] [PubMed]
    • Dludla, P.V.; Muller, C.J.; Joubert, E.; Louw, J.; Gabuza, K.B.; Huisamen, B.; Essop, M.F.; Johnson, R. Phenylpyruvic acid-2-O-D-glucoside attenuates high glucose-induced apoptosis in H9c2 cardiomyocytes. Planta Med. 2016, 82, 1468-1474. [CrossRef] [PubMed]
    • (2016) Planta Med. , vol.82 , pp. 1468-1474
    • Dludla, P.V.1    Muller, C.J.2    Joubert, E.3    Louw, J.4    Gabuza, K.B.5    Huisamen, B.6    Essop, M.F.7    Johnson, R.8
  • 49
    • 84939652973 scopus 로고    scopus 로고
    • Natural products for the treatment of type 2 diabetes mellitus
    • [CrossRef] [PubMed]
    • Rios, J.L.; Francini, F.; Schinella, G.R. Natural products for the treatment of type 2 diabetes mellitus. Planta Med. 2015, 81, 975-994. [CrossRef] [PubMed]
    • (2015) Planta Med. , vol.81 , pp. 975-994
    • Rios, J.L.1    Francini, F.2    Schinella, G.R.3
  • 50
    • 84997497931 scopus 로고    scopus 로고
    • Inhibitory interactions of Aspalathus linearis (Rooibos) extracts and compounds, aspalathin and z-2-(α-D-glucopyranosyloxy)-3-phenylpropenoic acid, on cytochromes metabolizing hypoglycemic and hypolipidemic drugs
    • [CrossRef] [PubMed]
    • Patel, O.; Muller, C.; Joubert, E.; Louw, J.; Rosenkranz, B.; Awortwe, C. Inhibitory interactions of Aspalathus linearis (Rooibos) extracts and compounds, aspalathin and z-2-(α-D-glucopyranosyloxy)-3-phenylpropenoic acid, on cytochromes metabolizing hypoglycemic and hypolipidemic drugs. Molecules 2016, 21, 1515. [CrossRef] [PubMed]
    • (2016) Molecules , vol.21 , pp. 1515
    • Patel, O.1    Muller, C.2    Joubert, E.3    Louw, J.4    Rosenkranz, B.5    Awortwe, C.6
  • 52
    • 79954488953 scopus 로고    scopus 로고
    • Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes
    • [CrossRef] [PubMed]
    • Karagiannis, T.C.; Lin, A.J.; Ververis, K.; Chang, L.; Tang, M.M.; Okabe, J.; El-Osta, A. Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes. Aging 2010, 2, 659-668. [CrossRef] [PubMed]
    • (2010) Aging , vol.2 , pp. 659-668
    • Karagiannis, T.C.1    Lin, A.J.2    Ververis, K.3    Chang, L.4    Tang, M.M.5    Okabe, J.6    El-Osta, A.7
  • 54
    • 1542318966 scopus 로고    scopus 로고
    • Autogenous transplantation of a duct ligated pancreas: A functional and histological study
    • Page, B.J.; du Toit, D.F.; Muller, C.J.; Mattysen, J.; Lyners, R.; Arends, E. Autogenous transplantation of a duct ligated pancreas: A functional and histological study. J. Oncol. Pract. 2004, 5, 71-80.
    • (2004) J. Oncol. Pract. , vol.5 , pp. 71-80
    • Page, B.J.1    Du Toit, D.F.2    Muller, C.J.3    Mattysen, J.4    Lyners, R.5    Arends, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.