-
1
-
-
0034507632
-
Transcription of eukaryotic protein-coding genes
-
Lee, T. I. & Young, R. A. Transcription of eukaryotic protein-coding genes. Annu. Rev. Genet. 34, 77-137 (2000).
-
(2000)
Annu. Rev. Genet.
, vol.34
, pp. 77-137
-
-
Lee, T.I.1
Young, R.A.2
-
2
-
-
0034212441
-
Transcriptional regulation through mediator-like coactivators in yeast and metazoan cells
-
Malik, S. & Roeder, R. G. Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells. Trends Biochem. Sci. 25, 277-283 (2000).
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 277-283
-
-
Malik, S.1
Roeder, R.G.2
-
3
-
-
0033786937
-
Mediator of transcriptional regulation
-
Myers, L. C. & Kornberg, R. D. Mediator of transcriptional regulation. Annu. Rev. Biochem. 69, 729-749 (2000).
-
(2000)
Annu. Rev. Biochem.
, vol.69
, pp. 729-749
-
-
Myers, L.C.1
Kornberg, R.D.2
-
4
-
-
0032567081
-
Dissecting the regulatory circuitry of a eukaryotic genome
-
Holstege, F. C. et al. Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95, 717-728 (1998).
-
(1998)
Cell
, vol.95
, pp. 717-728
-
-
Holstege, F.C.1
-
5
-
-
79952803747
-
Direct interaction of RNA polymerase II and mediator required for transcription in vivo
-
This study provides in vivo evidence that a direct interaction between Pol II and Mediator is generally required for Pol II recruitment and transcription in yeast
-
Soutourina, J., Wydau, S., Ambroise, Y., Boschiero, C. & Werner, M. Direct interaction of RNA polymerase II and mediator required for transcription in vivo. Science 331, 1451-1454 (2011). This study provides in vivo evidence that a direct interaction between Pol II and Mediator is generally required for Pol II recruitment and transcription in yeast.
-
(2011)
Science
, vol.331
, pp. 1451-1454
-
-
Soutourina, J.1
Wydau, S.2
Ambroise, Y.3
Boschiero, C.4
Werner, M.5
-
6
-
-
0029076822
-
General requirement for RNA polymerase II holoenzymes in vivo
-
Thompson, C. M. & Young, R. A. General requirement for RNA polymerase II holoenzymes in vivo. Proc. Natl Acad. Sci. USA 92, 4587-4590 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 4587-4590
-
-
Thompson, C.M.1
Young, R.A.2
-
7
-
-
0036645671
-
The trap100 component of the trap/mediator complex is essential in broad transcriptional events and development
-
Ito, M., Okano, H. J., Darnell, R. B. & Roeder, R. G. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J. 21, 3464-3475 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 3464-3475
-
-
Ito, M.1
Okano, H.J.2
Darnell, R.B.3
Roeder, R.G.4
-
8
-
-
0033635048
-
Involvement of the trap220 component of the trap/smcc coactivator complex in embryonic development and thyroid hormone action
-
Ito, M., Yuan, C. X., Okano, H. J., Darnell, R. B. & Roeder, R. G. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol. Cell 5, 683-693 (2000).
-
(2000)
Mol. Cell
, vol.5
, pp. 683-693
-
-
Ito, M.1
Yuan, C.X.2
Okano, H.J.3
Darnell, R.B.4
Roeder, R.G.5
-
9
-
-
0037177573
-
Transcription control by e1a and map kinase pathway via sur2 mediator subunit
-
Stevens, J. L. et al. Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science 296, 755-758 (2002).
-
(2002)
Science
, vol.296
, pp. 755-758
-
-
Stevens, J.L.1
-
10
-
-
0033567983
-
Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit srb7 in mice
-
Tudor, M., Murray, P. J., Onufryk, C., Jaenisch, R. & Young, R. A. Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Genes Dev. 13, 2365-2368 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 2365-2368
-
-
Tudor, M.1
Murray, P.J.2
Onufryk, C.3
Jaenisch, R.4
Young, R.A.5
-
11
-
-
34548210859
-
Cdk8 is essential for preimplantation mouse development
-
Westerling, T., Kuuluvainen, E. & Makela, T. P. Cdk8 is essential for preimplantation mouse development. Mol. Cell. Biol. 27, 6177-6182 (2007).
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 6177-6182
-
-
Westerling, T.1
Kuuluvainen, E.2
Makela, T.P.3
-
12
-
-
77958111633
-
The metazoan mediator co-Activator complex as an integrative hub for transcriptional regulation
-
Malik, S. & Roeder, R. G. The metazoan Mediator co-Activator complex as an integrative hub for transcriptional regulation. Nat. Rev. Genet. 11, 761-772 (2010).
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 761-772
-
-
Malik, S.1
Roeder, R.G.2
-
13
-
-
84858165145
-
Genome-wide structure and organization of eukaryotic pre-initiation complexes
-
This study uses a precise map of PIC components, including Pol II and GTFs, in the yeast genome to identify TATA-like elements bound by TBP
-
Rhee, H. S. & Pugh, B. F. Genome-wide structure and organization of eukaryotic pre-initiation complexes. Nature 483, 295-301 (2012). This study uses a precise map of PIC components, including Pol II and GTFs, in the yeast genome to identify TATA-like elements bound by TBP.
-
(2012)
Nature
, vol.483
, pp. 295-301
-
-
Rhee, H.S.1
Pugh, B.F.2
-
14
-
-
84888588009
-
The mediator complex and transcription regulation
-
Poss, Z. C., Ebmeier, C. C. & Taatjes, D. J. The Mediator complex and transcription regulation. Crit. Rev. Biochem. Mol. Biol. 48, 575-608 (2013).
-
(2013)
Crit. Rev. Biochem. Mol. Biol.
, vol.48
, pp. 575-608
-
-
Poss, Z.C.1
Ebmeier, C.C.2
Taatjes, D.J.3
-
15
-
-
77949266564
-
Mediator head module structure and functional interactions
-
Cai, G. et al. Mediator head module structure and functional interactions. Nat. Struct. Mol. Biol. 17, 273-279 (2010).
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 273-279
-
-
Cai, G.1
-
16
-
-
48349095490
-
Mediator-dependent recruitment of tfiih modules in preinitiation complex
-
Esnault, C. et al. Mediator-dependent recruitment of TFIIH modules in preinitiation complex. Mol. Cell 31, 337-346 (2008).
-
(2008)
Mol. Cell
, vol.31
, pp. 337-346
-
-
Esnault, C.1
-
17
-
-
84959440432
-
Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo
-
Eyboulet, F. et al. Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo. Nucleic Acids Res. 43, 9214-9231 (2015).
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. 9214-9231
-
-
Eyboulet, F.1
-
18
-
-
84990985860
-
Functional interplay between mediator and tfiib in preinitiation complex assembly in relation to promoter architecture
-
On the basis of in vivo, in vitro and in silico approaches, this study reveals a functional interplay between yeast Mediator and TFIIB in close relation to the promoter architecture
-
Eychenne, T. et al. Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture. Genes Dev. 30, 2119-2132 (2016). On the basis of in vivo, in vitro and in silico approaches, this study reveals a functional interplay between yeast Mediator and TFIIB in close relation to the promoter architecture.
-
(2016)
Genes Dev.
, vol.30
, pp. 2119-2132
-
-
Eychenne, T.1
-
19
-
-
0037099312
-
Tfiid and human mediator coactivator complexes assemble cooperatively on promoter DNA
-
Johnson, K. M., Wang, J., Smallwood, A., Arayata, C. & Carey, M. TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA. Genes Dev. 16, 1852-1863 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 1852-1863
-
-
Johnson, K.M.1
Wang, J.2
Smallwood, A.3
Arayata, C.4
Carey, M.5
-
20
-
-
33749514827
-
Structure and tbp binding of the mediator head subcomplex med8-med18-med20
-
Lariviere, L. et al. Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20. Nat. Struct. Mol. Biol. 13, 895-901 (2006).
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 895-901
-
-
Lariviere, L.1
-
21
-
-
79959939884
-
Human mediator subunit med26 functions as a docking site for transcription elongation factors
-
Takahashi, H. et al. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell 146, 92-104 (2011).
-
(2011)
Cell
, vol.146
, pp. 92-104
-
-
Takahashi, H.1
-
22
-
-
0028282551
-
A multiprotein mediator of transcriptional activation and its interaction with the c-terminal repeat domain of RNA polymerase II
-
Kim, Y. J., Bjorklund, S., Li, Y., Sayre, M. H. & Kornberg, R. D. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 77, 599-608 (1994).
-
(1994)
Cell
, vol.77
, pp. 599-608
-
-
Kim, Y.J.1
Bjorklund, S.2
Li, Y.3
Sayre, M.H.4
Kornberg, R.D.5
-
23
-
-
0034626731
-
A transcription reinitiation intermediate that is stabilized by activator
-
Yudkovsky, N., Ranish, J. A. & Hahn, S. A transcription reinitiation intermediate that is stabilized by activator. Nature 408, 225-229 (2000).
-
(2000)
Nature
, vol.408
, pp. 225-229
-
-
Yudkovsky, N.1
Ranish, J.A.2
Hahn, S.3
-
24
-
-
84923811117
-
The mediator complex: A central integrator of transcription
-
Allen, B. L. & Taatjes, D. J. The Mediator complex: A central integrator of transcription. Nat. Rev. Mol. Cell Biol. 16, 155-166 (2015).
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, pp. 155-166
-
-
Allen, B.L.1
Taatjes, D.J.2
-
25
-
-
47249134314
-
Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex
-
Bourbon, H. M. Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex. Nucleic Acids Res. 36, 3993-4008 (2008).
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 3993-4008
-
-
Bourbon, H.M.1
-
26
-
-
18844451820
-
Mediator and the mechanism of transcriptional activation
-
Kornberg, R. D. Mediator and the mechanism of transcriptional activation. Trends Biochem. Sci. 30, 235-239 (2005).
-
(2005)
Trends Biochem. Sci.
, vol.30
, pp. 235-239
-
-
Kornberg, R.D.1
-
27
-
-
84902186552
-
Subunit architecture and functional modular rearrangements of the transcriptional mediator complex
-
Tsai, K. L. et al. Subunit architecture and functional modular rearrangements of the transcriptional mediator complex. Cell 157, 1430-1444 (2014).
-
(2014)
Cell
, vol.157
, pp. 1430-1444
-
-
Tsai, K.L.1
-
28
-
-
84903816704
-
Redefining the modular organization of the core mediator complex
-
Wang, X. et al. Redefining the modular organization of the core Mediator complex. Cell Res. 24, 796-808 (2014).
-
(2014)
Cell Res.
, vol.24
, pp. 796-808
-
-
Wang, X.1
-
29
-
-
84923319299
-
Reconstitution of active human core mediator complex reveals a critical role of the med14 subunit
-
This work with a reconstituted human Mediator core complex shows that the MED14 subunit is critical for Mediator architecture and function
-
Cevher, M. A. et al. Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit. Nat. Struct. Mol. Biol. 21, 1028-1034 (2014). This work with a reconstituted human Mediator core complex shows that the MED14 subunit is critical for Mediator architecture and function.
-
(2014)
Nat. Struct. Mol. Biol.
, vol.21
, pp. 1028-1034
-
-
Cevher, M.A.1
-
30
-
-
84923358406
-
Architecture of the RNA polymerase II-mediator core initiation complex
-
This work provides a cryo-EM model for a recombinant 15-subunit yeast Mediator core within a partially assembled PIC
-
Plaschka, C. et al. Architecture of the RNA polymerase II-Mediator core initiation complex. Nature 518, 376-380 (2015). This work provides a cryo-EM model for a recombinant 15-subunit yeast Mediator core within a partially assembled PIC.
-
(2015)
Nature
, vol.518
, pp. 376-380
-
-
Plaschka, C.1
-
31
-
-
84861963339
-
A structural perspective on mediator function
-
Lariviere, L., Seizl, M. & Cramer, P. A structural perspective on Mediator function. Curr. Opin. Cell Biol. 24, 305-313 (2012).
-
(2012)
Curr. Opin. Cell Biol.
, vol.24
, pp. 305-313
-
-
Lariviere, L.1
Seizl, M.2
Cramer, P.3
-
32
-
-
79960434142
-
Architecture of the mediator head module
-
Imasaki, T. et al. Architecture of the Mediator head module. Nature 475, 240-243 (2011).
-
(2011)
Nature
, vol.475
, pp. 240-243
-
-
Imasaki, T.1
-
33
-
-
84871456902
-
Structure of the mediator head module
-
Lariviere, L. et al. Structure of the Mediator head module. Nature 492, 448-451 (2012).
-
(2012)
Nature
, vol.492
, pp. 448-451
-
-
Lariviere, L.1
-
34
-
-
84868094446
-
Structure of the mediator head module bound to the carboxy-terminal domain of RNA polymerase II
-
Robinson, P. J., Bushnell, D. A., Trnka, M. J., Burlingame, A. L. & Kornberg, R. D. Structure of the mediator head module bound to the carboxy-terminal domain of RNA polymerase II. Proc. Natl Acad. Sci. USA 109, 17931-17935 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 17931-17935
-
-
Robinson, P.J.1
Bushnell, D.A.2
Trnka, M.J.3
Burlingame, A.L.4
Kornberg, R.D.5
-
35
-
-
85019255956
-
Core mediator structure at 3.4 a extends model of transcription initiation complex
-
This work provides the crystal structure for the largest Mediator subcomplex obtained to date at high resolution, the 15-subunit Mediator core from fission yeast
-
Nozawa, K., Schneider, T. R. & Cramer, P. Core Mediator structure at 3.4 A extends model of transcription initiation complex. Nature 545, 248-251 (2017). This work provides the crystal structure for the largest Mediator subcomplex obtained to date at high resolution, the 15-subunit Mediator core from fission yeast.
-
(2017)
Nature
, vol.545
, pp. 248-251
-
-
Nozawa, K.1
Schneider, T.R.2
Cramer, P.3
-
36
-
-
84946593198
-
Molecular architecture of the yeast mediator complex
-
Robinson, P. J. et al. Molecular architecture of the yeast Mediator complex. eLife 4, e08719 (2015).
-
(2015)
ELife
, vol.4
, pp. e08719
-
-
Robinson, P.J.1
-
37
-
-
84986277745
-
Structure of a complete mediator-RNA polymerase II pre-initiation complex
-
In this paper, a cryo-EM model is proposed for a purified yeast Mediator complex lacking the Cdk8 kinase module, which was assembled in vitro with all GTFs and Pol II
-
Robinson, P. J. et al. Structure of a complete mediator-RNA polymerase II pre-initiation complex. Cell 166, 1411-1422 (2016). In this paper, a cryo-EM model is proposed for a purified yeast Mediator complex lacking the Cdk8 kinase module, which was assembled in vitro with all GTFs and Pol II.
-
(2016)
Cell
, vol.166
, pp. 1411-1422
-
-
Robinson, P.J.1
-
38
-
-
85027930061
-
Mediator structure and rearrangements required for holoenzyme formation
-
This work describes and compares cryo-EM models for fission yeast Mediator alone and in complex with Pol II, revealing conformational changes in Mediator that are associated with Mediator-Pol II interaction
-
Tsai, K. L. et al. Mediator structure and rearrangements required for holoenzyme formation. Nature 544, 196-201 (2017). This work describes and compares cryo-EM models for fission yeast Mediator alone and in complex with Pol II, revealing conformational changes in Mediator that are associated with Mediator-Pol II interaction.
-
(2017)
Nature
, vol.544
, pp. 196-201
-
-
Tsai, K.L.1
-
39
-
-
85007300609
-
Role for the med21-med7 hinge in assembly of the mediator-RNA polymerase II holoenzyme
-
Sato, S. et al. Role for the MED21-MED7 hinge in assembly of the mediator-RNA polymerase II holoenzyme. J. Biol. Chem. 291, 26886-26898 (2016).
-
(2016)
J. Biol. Chem.
, vol.291
, pp. 26886-26898
-
-
Sato, S.1
-
40
-
-
61449143491
-
The human cdk8 subcomplex is a molecular switch that controls mediator coactivator function
-
Knuesel, M. T., Meyer, K. D., Bernecky, C. & Taatjes, D. J. The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes Dev. 23, 439-451 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 439-451
-
-
Knuesel, M.T.1
Meyer, K.D.2
Bernecky, C.3
Taatjes, D.J.4
-
41
-
-
85027942059
-
A conserved mediator-cdk8 kinase module association regulates mediator-RNA polymerase II interaction
-
Tsai, K. L. et al. A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction. Nat. Struct. Mol. Biol. 20, 611-619 (2013).
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, pp. 611-619
-
-
Tsai, K.L.1
-
42
-
-
3042760385
-
The ras/pka signaling pathway directly targets the srb9 protein, a component of the general RNA polymerase II transcription apparatus
-
Chang, Y. W., Howard, S. C. & Herman, P. K. The Ras/PKA signaling pathway directly targets the Srb9 protein, a component of the general RNA polymerase II transcription apparatus. Mol. Cell 15, 107-116 (2004).
-
(2004)
Mol. Cell
, vol.15
, pp. 107-116
-
-
Chang, Y.W.1
Howard, S.C.2
Herman, P.K.3
-
43
-
-
84873051970
-
The scf-fbw7 ubiquitin ligase degrades med13 and med13l and regulates cdk8 module association with mediator
-
Davis, M. A. et al. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Genes Dev. 27, 151-156 (2013).
-
(2013)
Genes Dev.
, vol.27
, pp. 151-156
-
-
Davis, M.A.1
-
44
-
-
84880506629
-
Proteomic analysis of coregulators bound to eralpha on DNA and nucleosomes reveals coregulator dynamics
-
Foulds, C. E. et al. Proteomic analysis of coregulators bound to ERalpha on DNA and nucleosomes reveals coregulator dynamics. Mol. Cell 51, 185-199 (2013).
-
(2013)
Mol. Cell
, vol.51
, pp. 185-199
-
-
Foulds, C.E.1
-
45
-
-
84894386939
-
Suppression of mediator is regulated by cdk8-dependent grr1 turnover of the med3 coactivator
-
Gonzalez, D. et al. Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator. Proc. Natl Acad. Sci. USA 111, 2500-2505 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 2500-2505
-
-
Gonzalez, D.1
-
46
-
-
84940001123
-
The s. Cerevisiae sumo stress response is a conjugation-deconjugation cycle that targets the transcription machinery
-
Lewicki, M. C., Srikumar, T., Johnson, E. & Raught, B. The S. cerevisiae SUMO stress response is a conjugation-deconjugation cycle that targets the transcription machinery. J. Proteom. 118, 39-48 (2015).
-
(2015)
J. Proteom.
, vol.118
, pp. 39-48
-
-
Lewicki, M.C.1
Srikumar, T.2
Johnson, E.3
Raught, B.4
-
47
-
-
84871776789
-
Mediator phosphorylation prevents stress response transcription during non-stress conditions
-
Miller, C. et al. Mediator phosphorylation prevents stress response transcription during non-stress conditions. J. Biol. Chem. 287, 44017-44026 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 44017-44026
-
-
Miller, C.1
-
48
-
-
23744490065
-
Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets
-
van de Peppel, J. et al. Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets. Mol. Cell 19, 511-522 (2005).
-
(2005)
Mol. Cell
, vol.19
, pp. 511-522
-
-
Van De Peppel, J.1
-
49
-
-
84991619629
-
Opposing effects of elk-1 multisite phosphorylation shape its response to erk activation
-
This study proposes a regulatory mechanism for the fine-tuning of interactions between mammalian Mediator and the ELK1 activator through differential multisite phosphorylation to shape the transcriptional response
-
Mylona, A. et al. Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation. Science 354, 233-237 (2016). This study proposes a regulatory mechanism for the fine-tuning of interactions between mammalian Mediator and the ELK1 activator through differential multisite phosphorylation to shape the transcriptional response.
-
(2016)
Science
, vol.354
, pp. 233-237
-
-
Mylona, A.1
-
50
-
-
33646023157
-
Genome-wide location of the coactivator mediator: Binding without activation and transient cdk8 interaction on DNA
-
Andrau, J. C. et al. Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA. Mol. Cell 22, 179-192 (2006).
-
(2006)
Mol. Cell
, vol.22
, pp. 179-192
-
-
Andrau, J.C.1
-
51
-
-
84889067216
-
Mediator links transcription and DNA repair by facilitating rad2/xpg recruitment
-
Eyboulet, F. et al. Mediator links transcription and DNA repair by facilitating Rad2/XPG recruitment. Genes Dev. 27, 2549-2562 (2013).
-
(2013)
Genes Dev.
, vol.27
, pp. 2549-2562
-
-
Eyboulet, F.1
-
52
-
-
77957139539
-
Mediator and cohesin connect gene expression and chromatin architecture
-
Kagey, M. H. et al. Mediator and cohesin connect gene expression and chromatin architecture. Nature 467, 430-435 (2010).
-
(2010)
Nature
, vol.467
, pp. 430-435
-
-
Kagey, M.H.1
-
53
-
-
79951493843
-
A comprehensive genomic binding map of gene and chromatin regulatory proteins in saccharomyces
-
Venters, B. J. et al. A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol. Cell 41, 480-492 (2011).
-
(2011)
Mol. Cell
, vol.41
, pp. 480-492
-
-
Venters, B.J.1
-
54
-
-
82955217673
-
The cyc8-tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein
-
Wong, K. H. & Struhl, K. The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein. Genes Dev. 25, 2525-2539 (2011).
-
(2011)
Genes Dev.
, vol.25
, pp. 2525-2539
-
-
Wong, K.H.1
Struhl, K.2
-
55
-
-
70349745516
-
Mediator complex association with constitutively transcribed genes in yeast
-
Ansari, S. A., He, Q. & Morse, R. H. Mediator complex association with constitutively transcribed genes in yeast. Proc. Natl Acad. Sci. USA 106, 16734-16739 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 16734-16739
-
-
Ansari, S.A.1
He, Q.2
Morse, R.H.3
-
56
-
-
0344270881
-
Association of the mediator complex with enhancers of active genes
-
Kuras, L., Borggrefe, T. & Kornberg, R. D. Association of the Mediator complex with enhancers of active genes. Proc. Natl Acad. Sci. USA 100, 13887-13891 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 13887-13891
-
-
Kuras, L.1
Borggrefe, T.2
Kornberg, R.D.3
-
57
-
-
84876222028
-
Selective inhibition of tumor oncogenes by disruption of super-enhancers
-
Loven, J. et al. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell 153, 320-334 (2013).
-
(2013)
Cell
, vol.153
, pp. 320-334
-
-
Loven, J.1
-
58
-
-
84876216563
-
Master transcription factors and mediator establish super-enhancers at key cell identity genes
-
Whyte, W. A. et al. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 153, 307-319 (2013).
-
(2013)
Cell
, vol.153
, pp. 307-319
-
-
Whyte, W.A.1
-
59
-
-
84902073419
-
Kin28 regulates the transient association of mediator with core promoters
-
Jeronimo, C. & Robert, F. Kin28 regulates the transient association of Mediator with core promoters. Nat. Struct. Mol. Biol. 21, 449-455 (2014).
-
(2014)
Nat. Struct. Mol. Biol.
, vol.21
, pp. 449-455
-
-
Jeronimo, C.1
Robert, F.2
-
60
-
-
84901235459
-
Tfiih phosphorylation of the pol II ctd stimulates mediator dissociation from the preinitiation complex and promoter escape
-
Wong, K. H., Jin, Y. & Struhl, K. TFIIH phosphorylation of the Pol II CTD stimulates mediator dissociation from the preinitiation complex and promoter escape. Mol. Cell 54, 601-612 (2014).
-
(2014)
Mol. Cell
, vol.54
, pp. 601-612
-
-
Wong, K.H.1
Jin, Y.2
Struhl, K.3
-
61
-
-
84991790974
-
Mediator binding to uass is broadly uncoupled from transcription and cooperative with tfiid recruitment to promoters
-
This work based on an alternative approach to chromatin immunoprecipitation shows cooperative chromatin binding between budding yeast Mediator and TFIID
-
Grunberg, S., Henikoff, S., Hahn, S. & Zentner, G. E. Mediator binding to UASs is broadly uncoupled from transcription and cooperative with TFIID recruitment to promoters. EMBO J. 35, 2435-2446 (2016). This work based on an alternative approach to chromatin immunoprecipitation shows cooperative chromatin binding between budding yeast Mediator and TFIID.
-
(2016)
EMBO J.
, vol.35
, pp. 2435-2446
-
-
Grunberg, S.1
Henikoff, S.2
Hahn, S.3
Zentner, G.E.4
-
62
-
-
84995476616
-
Tail and kinase modules differently regulate core mediator recruitment and function in vivo
-
Jeronimo, C. et al. Tail and kinase modules differently regulate core Mediator recruitment and function in vivo. Mol. Cell 64, 455-466 (2016).
-
(2016)
Mol. Cell
, vol.64
, pp. 455-466
-
-
Jeronimo, C.1
-
63
-
-
84995519468
-
Mediator undergoes a compositional change during transcriptional activation
-
References 62 and 63 demonstrate the changes in modular Mediator organization in transcription regulation, presenting a differential role for the tail and kinase modules in Mediator recruitment in budding yeast
-
Petrenko, N., Jin, Y., Wong, K. H. & Struhl, K. Mediator undergoes a compositional change during transcriptional activation. Mol. Cell 64, 443-454 (2016). References 62 and 63 demonstrate the changes in modular Mediator organization in transcription regulation, presenting a differential role for the tail and kinase modules in Mediator recruitment in budding yeast.
-
(2016)
Mol. Cell
, vol.64
, pp. 443-454
-
-
Petrenko, N.1
Jin, Y.2
Wong, K.H.3
Struhl, K.4
-
64
-
-
84874368349
-
Activating rnas associate with mediator to enhance chromatin architecture and transcription
-
Lai, F. et al. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature 494, 497-501 (2013).
-
(2013)
Nature
, vol.494
, pp. 497-501
-
-
Lai, F.1
-
65
-
-
84879695128
-
Functional roles of enhancer rnas for oestrogen-dependent transcriptional activation
-
Li, W. et al. Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature 498, 516-520 (2013).
-
(2013)
Nature
, vol.498
, pp. 516-520
-
-
Li, W.1
-
66
-
-
14844349559
-
Structural and functional characterization of pc2 and RNA polymerase II-Associated subpopulations of metazoan mediator
-
Malik, S., Baek, H. J., Wu, W. & Roeder, R. G. Structural and functional characterization of PC2 and RNA polymerase II-Associated subpopulations of metazoan Mediator. Mol. Cell. Biol. 25, 2117-2129 (2005).
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 2117-2129
-
-
Malik, S.1
Baek, H.J.2
Wu, W.3
Roeder, R.G.4
-
67
-
-
20144389926
-
Parp-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator
-
Pavri, R. et al. PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol. Cell 18, 83-96 (2005).
-
(2005)
Mol. Cell
, vol.18
, pp. 83-96
-
-
Pavri, R.1
-
68
-
-
24044531563
-
Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of crabp1 dependent on med1/trap220
-
Park, S. W. et al. Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220. Mol. Cell 19, 643-653 (2005).
-
(2005)
Mol. Cell
, vol.19
, pp. 643-653
-
-
Park, S.W.1
-
69
-
-
24044540381
-
Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking
-
Wang, Q., Carroll, J. S. & Brown, M. Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Mol. Cell 19, 631-642 (2005).
-
(2005)
Mol. Cell
, vol.19
, pp. 631-642
-
-
Wang, Q.1
Carroll, J.S.2
Brown, M.3
-
70
-
-
0026696627
-
A novel transcription factor reveals a functional link between the RNA polymerase II ctd and tfiid
-
Koleske, A. J., Buratowski, S., Nonet, M. & Young, R. A. A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID. Cell 69, 883-894 (1992).
-
(1992)
Cell
, vol.69
, pp. 883-894
-
-
Koleske, A.J.1
Buratowski, S.2
Nonet, M.3
Young, R.A.4
-
71
-
-
0032900980
-
Intermediates in formation and activity of the RNA polymerase II preinitiation complex: Holoenzyme recruitment and a postrecruitment role for the tata box and tfiib
-
Ranish, J. A., Yudkovsky, N. & Hahn, S. Intermediates in formation and activity of the RNA polymerase II preinitiation complex: Holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB. Genes Dev. 13, 49-63 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 49-63
-
-
Ranish, J.A.1
Yudkovsky, N.2
Hahn, S.3
-
72
-
-
84901386953
-
Mediator, tata-binding protein, and RNA polymerase II contribute to low histone occupancy at active gene promoters in yeast
-
Ansari, S. A. et al. Mediator, TATA-binding protein, and RNA polymerase II contribute to low histone occupancy at active gene promoters in yeast. J. Biol. Chem. 289, 14981-14995 (2014).
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 14981-14995
-
-
Ansari, S.A.1
-
73
-
-
84860580120
-
Role of mediator in regulating pol II elongation and nucleosome displacement in saccharomyces cerevisiae
-
Kremer, S. B. et al. Role of Mediator in regulating Pol II elongation and nucleosome displacement in Saccharomyces cerevisiae. Genetics 191, 95-106 (2012).
-
(2012)
Genetics
, vol.191
, pp. 95-106
-
-
Kremer, S.B.1
-
74
-
-
84861905985
-
Med5(nut1) and med17(srb4) are direct targets of mediator histone h4 tail interactions
-
Liu, Z. & Myers, L. C. Med5(Nut1) and Med17(Srb4) are direct targets of mediator histone H4 tail interactions. PLoS ONE 7, e38416 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e38416
-
-
Liu, Z.1
Myers, L.C.2
-
75
-
-
0033635271
-
Mediator-nucleosome interaction
-
Lorch, Y., Beve, J., Gustafsson, C. M., Myers, L. C. & Kornberg, R. D. Mediator-nucleosome interaction. Mol. Cell 6, 197-201 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 197-201
-
-
Lorch, Y.1
Beve, J.2
Gustafsson, C.M.3
Myers, L.C.4
Kornberg, R.D.5
-
76
-
-
84871700533
-
Mediator-regulated transcription through the +1 nucleosome
-
Nock, A., Ascano, J. M., Barrero, M. J. & Malik, S. Mediator-regulated transcription through the +1 nucleosome. Mol. Cell 48, 837-848 (2012).
-
(2012)
Mol. Cell
, vol.48
, pp. 837-848
-
-
Nock, A.1
Ascano, J.M.2
Barrero, M.J.3
Malik, S.4
-
77
-
-
80455168342
-
Histone modifications influence mediator interactions with chromatin
-
Zhu, X. et al. Histone modifications influence mediator interactions with chromatin. Nucleic Acids Res. 39, 8342-8354 (2011).
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 8342-8354
-
-
Zhu, X.1
-
78
-
-
0028347674
-
An RNA polymerase II holoenzyme responsive to activators
-
Koleske, A. J. & Young, R. A. An RNA polymerase II holoenzyme responsive to activators. Nature 368, 466-469 (1994).
-
(1994)
Nature
, vol.368
, pp. 466-469
-
-
Koleske, A.J.1
Young, R.A.2
-
79
-
-
0024354605
-
Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of saccharomyces cerevisiae RNA polymerase II
-
Nonet, M. L. & Young, R. A. Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II. Genetics 123, 715-724 (1989).
-
(1989)
Genetics
, vol.123
, pp. 715-724
-
-
Nonet, M.L.1
Young, R.A.2
-
80
-
-
0027253864
-
A multisubunit complex associated with the RNA polymerase II ctd and tata-binding protein in yeast
-
Thompson, C. M., Koleske, A. J., Chao, D. M. & Young, R. A. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell 73, 1361-1375 (1993).
-
(1993)
Cell
, vol.73
, pp. 1361-1375
-
-
Thompson, C.M.1
Koleske, A.J.2
Chao, D.M.3
Young, R.A.4
-
81
-
-
0037214501
-
Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation
-
Reeves, W. M. & Hahn, S. Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation. Mol. Cell. Biol. 23, 349-358 (2003).
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 349-358
-
-
Reeves, W.M.1
Hahn, S.2
-
82
-
-
38049146018
-
Protein characterization of saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking
-
Tardiff, D. F., Abruzzi, K. C. & Rosbash, M. Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking. Proc. Natl Acad. Sci. USA 104, 19948-19953 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 19948-19953
-
-
Tardiff, D.F.1
Abruzzi, K.C.2
Rosbash, M.3
-
83
-
-
0036671095
-
Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction
-
Davis, J. A., Takagi, Y., Kornberg, R. D. & Asturias, F. A. Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction. Mol. Cell 10, 409-415 (2002).
-
(2002)
Mol. Cell
, vol.10
, pp. 409-415
-
-
Davis, J.A.1
Takagi, Y.2
Kornberg, R.D.3
Asturias, F.A.4
-
84
-
-
79953713243
-
Molecular architecture of the human mediator-RNA polymerase II-tfIIf assembly
-
Bernecky, C., Grob, P., Ebmeier, C. C., Nogales, E. & Taatjes, D. J. Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly. PLoS Biol. 9, e1000603 (2011).
-
(2011)
PLoS Biol.
, vol.9
, pp. e1000603
-
-
Bernecky, C.1
Grob, P.2
Ebmeier, C.C.3
Nogales, E.4
Taatjes, D.J.5
-
85
-
-
0036199506
-
Requirement of trap/mediator for both activatorindependent and activator-dependent transcription in conjunction with tfiid-Associated tafiis
-
Baek, H. J., Malik, S., Qin, J. & Roeder, R. G. Requirement of TRAP/Mediator for both activatorindependent and activator-dependent transcription in conjunction with TFIID-Associated TAFIIs. Mol. Cell. Biol. 22, 2842-2852 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2842-2852
-
-
Baek, H.J.1
Malik, S.2
Qin, J.3
Roeder, R.G.4
-
86
-
-
0033542436
-
Binding of tbp to promoters in vivo is stimulated by activators and requires pol II holoenzyme
-
Kuras, L. & Struhl, K. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme. Nature 399, 609-613 (1999).
-
(1999)
Nature
, vol.399
, pp. 609-613
-
-
Kuras, L.1
Struhl, K.2
-
87
-
-
0033542484
-
Enhancement of tbp binding by activators and general transcription factors
-
Li, X. Y., Virbasius, A., Zhu, X. & Green, M. R. Enhancement of TBP binding by activators and general transcription factors. Nature 399, 605-609 (1999).
-
(1999)
Nature
, vol.399
, pp. 605-609
-
-
Li, X.Y.1
Virbasius, A.2
Zhu, X.3
Green, M.R.4
-
88
-
-
33744948144
-
Human mediator enhances basal transcription by facilitating recruitment of transcription factor iib during preinitiation complex assembly
-
Baek, H. J., Kang, Y. K. & Roeder, R. G. Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly. J. Biol. Chem. 281, 15172-15181 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 15172-15181
-
-
Baek, H.J.1
Kang, Y.K.2
Roeder, R.G.3
-
89
-
-
0035834772
-
The structural and functional organization of the yeast mediator complex
-
Kang, J. S. et al. The structural and functional organization of the yeast mediator complex. J. Biol. Chem. 276, 42003-42010 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42003-42010
-
-
Kang, J.S.1
-
90
-
-
60349089645
-
Nucleosome positioning and gene regulation: Advances through genomics
-
Jiang, C. & Pugh, B. F. Nucleosome positioning and gene regulation: Advances through genomics. Nat. Rev. Genet. 10, 161-172 (2009).
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 161-172
-
-
Jiang, C.1
Pugh, B.F.2
-
91
-
-
85026913454
-
Understanding nucleosome dynamics and their links to gene expression and DNA replication
-
Lai, W. K. M. & Pugh, B. F. Understanding nucleosome dynamics and their links to gene expression and DNA replication. Nat. Rev. Mol. Cell Biol. 18, 548-562 (2017).
-
(2017)
Nat. Rev. Mol. Cell Biol.
, vol.18
, pp. 548-562
-
-
Lai, W.K.M.1
Pugh, B.F.2
-
92
-
-
33947137710
-
Dynamics of replication-independent histone turnover in budding yeast
-
Dion, M. F. et al. Dynamics of replication-independent histone turnover in budding yeast. Science 315, 1405-1408 (2007).
-
(2007)
Science
, vol.315
, pp. 1405-1408
-
-
Dion, M.F.1
-
93
-
-
84867436452
-
Proteomic analysis demonstrates activator-And chromatin-specific recruitment to promoters
-
Sikorski, T. W. et al. Proteomic analysis demonstrates activator-And chromatin-specific recruitment to promoters. J. Biol. Chem. 287, 35397-35408 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 35397-35408
-
-
Sikorski, T.W.1
-
94
-
-
85012960893
-
Chromatin potentiates transcription
-
Nagai, S., Davis, R. E., Mattei, P. J., Eagen, K. P. & Kornberg, R. D. Chromatin potentiates transcription. Proc. Natl Acad. Sci. USA 114, 1536-1541 (2017).
-
(2017)
Proc. Natl Acad. Sci. USA
, vol.114
, pp. 1536-1541
-
-
Nagai, S.1
Davis, R.E.2
Mattei, P.J.3
Eagen, K.P.4
Kornberg, R.D.5
-
95
-
-
36049014424
-
Tfiis elongation factor and mediator act in conjunction during transcription initiation in vivo
-
Guglielmi, B., Soutourina, J., Esnault, C. & Werner, M. TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo. Proc. Natl Acad. Sci. USA 104, 16062-16067 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 16062-16067
-
-
Guglielmi, B.1
Soutourina, J.2
Esnault, C.3
Werner, M.4
-
96
-
-
36049035016
-
The transcription elongation factor tfiis is a component of RNA polymerase II preinitiation complexes
-
Kim, B. et al. The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes. Proc. Natl Acad. Sci. USA 104, 16068-16073 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 16068-16073
-
-
Kim, B.1
-
97
-
-
84867160564
-
The RNA polymerase II ctd coordinates transcription and RNA processing
-
Hsin, J. P. & Manley, J. L. The RNA polymerase II CTD coordinates transcription and RNA processing. Genes Dev. 26, 2119-2137 (2012).
-
(2012)
Genes Dev.
, vol.26
, pp. 2119-2137
-
-
Hsin, J.P.1
Manley, J.L.2
-
98
-
-
84966702471
-
Dynamic encounters of genes and transcripts with the nuclear pore
-
Ben-Yishay, R., Ashkenazy, A. J. & Shav-Tal, Y. Dynamic encounters of genes and transcripts with the nuclear pore. Trends Genet. 32, 419-431 (2016).
-
(2016)
Trends Genet.
, vol.32
, pp. 419-431
-
-
Ben-Yishay, R.1
Ashkenazy, A.J.2
Shav-Tal, Y.3
-
99
-
-
84894318075
-
Coupling mRNA processing with transcription in time and space
-
Bentley, D. L. Coupling mRNA processing with transcription in time and space. Nat. Rev. Genet. 15, 163-175 (2014).
-
(2014)
Nat. Rev. Genet.
, vol.15
, pp. 163-175
-
-
Bentley, D.L.1
-
100
-
-
84903160967
-
Structural basis for binding the trex2 complex to nuclear pores gal1 localisation and mRNA export
-
Jani, D., Valkov, E. & Stewart, M. Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export. Nucleic Acids Res. 42, 6686-6697 (2014).
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. 6686-6697
-
-
Jani, D.1
Valkov, E.2
Stewart, M.3
-
101
-
-
84940504501
-
The nuclear pore-Associated trex-2 complex employs mediator to regulate gene expression
-
This study suggests that yeast Mediator is involved in nuclear gene positioning and regulation of transcription via direct contact with the nuclear-pore-Associated TREX2 complex
-
Schneider, M. et al. The nuclear pore-Associated TREX-2 complex employs mediator to regulate gene expression. Cell 162, 1016-1028 (2015). This study suggests that yeast Mediator is involved in nuclear gene positioning and regulation of transcription via direct contact with the nuclear-pore-Associated TREX2 complex.
-
(2015)
Cell
, vol.162
, pp. 1016-1028
-
-
Schneider, M.1
-
102
-
-
84934435162
-
Mapping nucleosome resolution chromosome folding in yeast by micro-c
-
Hsieh, T. H. et al. Mapping nucleosome resolution chromosome folding in yeast by Micro-C. Cell 162, 108-119 (2015).
-
(2015)
Cell
, vol.162
, pp. 108-119
-
-
Hsieh, T.H.1
-
103
-
-
84901446291
-
Mechanisms of epigenetic memory
-
D'Urso, A. & Brickner, J. H. Mechanisms of epigenetic memory. Trends Genet. 30, 230-236 (2014).
-
(2014)
Trends Genet.
, vol.30
, pp. 230-236
-
-
D'Urso, A.1
Brickner, J.H.2
-
104
-
-
84994311328
-
Epigenetic transcriptional memory
-
D'Urso, A. & Brickner, J. H. Epigenetic transcriptional memory. Curr. Genet. 63, 435-439 (2016).
-
(2016)
Curr. Genet.
, vol.63
, pp. 435-439
-
-
D'Urso, A.1
Brickner, J.H.2
-
105
-
-
84979699629
-
Set1/compass and mediator are repurposed to promote epigenetic transcriptional memory
-
This study proposes a mechanism for Mediator in transcriptional memory that is related to the association of the nuclear pore with corresponding genes
-
D'Urso, A. et al. Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory. eLife 5, e16691 (2016). This study proposes a mechanism for Mediator in transcriptional memory that is related to the association of the nuclear pore with corresponding genes.
-
(2016)
ELife
, vol.5
, pp. e16691
-
-
D'Urso, A.1
-
106
-
-
33750481873
-
The cyclin-dependent kinase 8 module sterically blocks mediator interactions with RNA polymerase II
-
Elmlund, H. et al. The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II. Proc. Natl Acad. Sci. USA 103, 15788-15793 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 15788-15793
-
-
Elmlund, H.1
-
107
-
-
0036606879
-
Human crsp interacts with RNA polymerase II ctd and adopts a specific ctd-bound conformation
-
Naar, A. M., Taatjes, D. J., Zhai, W., Nogales, E. & Tjian, R. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev. 16, 1339-1344 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 1339-1344
-
-
Naar, A.M.1
Taatjes, D.J.2
Zhai, W.3
Nogales, E.4
Tjian, R.5
-
108
-
-
34247341747
-
H2a. Z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state
-
Brickner, D. G. et al. H2A. Z-Mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state. PLoS Biol. 5, e81 (2007).
-
(2007)
PLoS Biol.
, vol.5
, pp. e81
-
-
Brickner, D.G.1
-
109
-
-
77957377062
-
Interaction of a DNA zip code with the nuclear pore complex promotes h2a. Z incorporation and ino1 transcriptional memory
-
Light, W. H., Brickner, D. G., Brand, V. R. & Brickner, J. H. Interaction of a DNA zip code with the nuclear pore complex promotes H2A. Z incorporation and INO1 transcriptional memory. Mol. Cell 40, 112-125 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 112-125
-
-
Light, W.H.1
Brickner, D.G.2
Brand, V.R.3
Brickner, J.H.4
-
110
-
-
84890877213
-
Involvement of mediator complex in malignancy
-
Schiano, C. et al. Involvement of Mediator complex in malignancy. Biochim. Biophys. Acta 1845, 66-83 (2014).
-
(2014)
Biochim. Biophys. Acta
, vol.1845
, pp. 66-83
-
-
Schiano, C.1
-
111
-
-
80455164621
-
Mediator and human disease
-
Spaeth, J. M., Kim, N. H. & Boyer, T. G. Mediator and human disease. Semin. Cell Dev. Biol. 22, 776-787 (2011).
-
(2011)
Semin. Cell Dev. Biol.
, vol.22
, pp. 776-787
-
-
Spaeth, J.M.1
Kim, N.H.2
Boyer, T.G.3
-
112
-
-
84944257870
-
Mediator kinase inhibition further activates super-enhancer-Associated genes in AML
-
This work proposes an inhibition of mammalian Mediator kinase as a potential therapeutic for targeting Mediator in cancers
-
Pelish, H. E. et al. Mediator kinase inhibition further activates super-enhancer-Associated genes in AML. Nature 526, 273-276 (2015). This work proposes an inhibition of mammalian Mediator kinase as a potential therapeutic for targeting Mediator in cancers.
-
(2015)
Nature
, vol.526
, pp. 273-276
-
-
Pelish, H.E.1
-
113
-
-
84959352865
-
Inhibiting fungal multidrug resistance by disrupting an activator-mediator interaction
-
This study proposes that disrupting activator-Mediator contacts could be used for therapeutic targeting of fungal infectious diseases
-
Nishikawa, J. L. et al. Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nature 530, 485-489 (2016). This study proposes that disrupting activator-Mediator contacts could be used for therapeutic targeting of fungal infectious diseases.
-
(2016)
Nature
, vol.530
, pp. 485-489
-
-
Nishikawa, J.L.1
-
114
-
-
52949111487
-
Cdk8 is a colorectal cancer oncogene that regulates beta-catenin activity
-
Firestein, R. et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature 455, 547-551 (2008).
-
(2008)
Nature
, vol.455
, pp. 547-551
-
-
Firestein, R.1
-
115
-
-
84888015137
-
Super-enhancers in the control of cell identity and disease
-
Hnisz, D. et al. Super-enhancers in the control of cell identity and disease. Cell 155, 934-947 (2013).
-
(2013)
Cell
, vol.155
, pp. 934-947
-
-
Hnisz, D.1
-
116
-
-
84962054069
-
Identification of mediator kinase substrates in human cells using cortistatin a and quantitative phosphoproteomics
-
Poss, Z. C. et al. Identification of Mediator kinase substrates in human cells using cortistatin A and quantitative phosphoproteomics. Cell Rep. 15, 436-450 (2016).
-
(2016)
Cell Rep.
, vol.15
, pp. 436-450
-
-
Poss, Z.C.1
-
117
-
-
81255140709
-
The acidic transcription activator gcn4 binds the mediator subunit gal11/med15 using a simple protein interface forming a fuzzy complex
-
Brzovic, P. S. et al. The acidic transcription activator Gcn4 binds the mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex. Mol. Cell 44, 942-953 (2011).
-
(2011)
Mol. Cell
, vol.44
, pp. 942-953
-
-
Brzovic, P.S.1
-
118
-
-
41649118757
-
A nuclear receptor-like pathway regulating multidrug resistance in fungi
-
Thakur, J. K. et al. A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature 452, 604-609 (2008).
-
(2008)
Nature
, vol.452
, pp. 604-609
-
-
Thakur, J.K.1
-
119
-
-
84906658475
-
A sequence-specific transcription activator motif and powerful synthetic variants that bind mediator using a fuzzy protein interface
-
Warfield, L., Tuttle, L. M., Pacheco, D., Klevit, R. E. & Hahn, S. A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface. Proc. Natl Acad. Sci. USA 111, E3506-E3513 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. E3506-E3513
-
-
Warfield, L.1
Tuttle, L.M.2
Pacheco, D.3
Klevit, R.E.4
Hahn, S.5
-
120
-
-
0036318299
-
Trap/smcc/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4
-
Malik, S., Wallberg, A. E., Kang, Y. K. & Roeder, R. G. TRAP/SMCC/Mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4 Mol. Cell. Biol. 22, 5626-5637 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5626-5637
-
-
Malik, S.1
Wallberg, A.E.2
Kang, Y.K.3
Roeder, R.G.4
-
121
-
-
14644427848
-
Mediator requirement for both recruitment and postrecruitment steps in transcription initiation
-
Wang, G. et al. Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol. Cell 17, 683-694 (2005).
-
(2005)
Mol. Cell
, vol.17
, pp. 683-694
-
-
Wang, G.1
-
122
-
-
84979920522
-
A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting
-
Tantale, K. et al. A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting. Nat. Commun. 7, 12248 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 12248
-
-
Tantale, K.1
-
123
-
-
0025891809
-
A mediator required for activation of RNA polymerase II transcription in vitro
-
Flanagan, P. M., Kelleher, R. J. 3rd, Sayre, M. H., Tschochner, H. & Kornberg, R. D. A mediator required for activation of RNA polymerase II transcription in vitro. Nature 350, 436-438 (1991).
-
(1991)
Nature
, vol.350
, pp. 436-438
-
-
Flanagan, P.M.1
Kelleher, R.J.2
Sayre, M.H.3
Tschochner, H.4
Kornberg, R.D.5
-
124
-
-
34249826038
-
Purification of a plant mediator from arabidopsis thaliana identifies pft1 as the med25 subunit
-
Backstrom, S., Elfving, N., Nilsson, R., Wingsle, G. & Bjorklund, S. Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit. Mol. Cell 26, 717-729 (2007).
-
(2007)
Mol. Cell
, vol.26
, pp. 717-729
-
-
Backstrom, S.1
Elfving, N.2
Nilsson, R.3
Wingsle, G.4
Bjorklund, S.5
-
125
-
-
2942610696
-
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II
-
Bourbon, H. M. et al. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol. Cell 14, 553-557 (2004).
-
(2004)
Mol. Cell
, vol.14
, pp. 553-557
-
-
Bourbon, H.M.1
-
126
-
-
84960482942
-
Evolution of disorder in mediator complex and its functional relevance
-
Nagulapalli, M., Maji, S., Dwivedi, N., Dahiya, P. & Thakur, J. K. Evolution of disorder in Mediator complex and its functional relevance. Nucleic Acids Res. 44, 1591-1612 (2016).
-
(2016)
Nucleic Acids Res.
, vol.44
, pp. 1591-1612
-
-
Nagulapalli, M.1
Maji, S.2
Dwivedi, N.3
Dahiya, P.4
Thakur, J.K.5
-
127
-
-
58149163281
-
Malleable machines in transcription regulation: The mediator complex
-
Toth-Petroczy, A. et al. Malleable machines in transcription regulation: The mediator complex. PLoS Comput. Biol. 4, e1000243 (2008).
-
(2008)
PLoS Comput. Biol.
, vol.4
, pp. e1000243
-
-
Toth-Petroczy, A.1
-
128
-
-
85013491971
-
Biomolecular condensates: Organizers of cellular biochemistry
-
Banani, S. F., Lee, H. O., Hyman, A. A. & Rosen, M. K. Biomolecular condensates: Organizers of cellular biochemistry. Nat. Rev. Mol. Cell Biol. 18, 285-298 (2017).
-
(2017)
Nat. Rev. Mol. Cell Biol.
, vol.18
, pp. 285-298
-
-
Banani, S.F.1
Lee, H.O.2
Hyman, A.A.3
Rosen, M.K.4
-
129
-
-
85015990396
-
Phase separation model for transcriptional control
-
Hnisz, D., Shrinivas, K., Young, R. A., Chakraborty, A. K. & Sharp, P. A. A. Phase separation model for transcriptional control. Cell 169, 13-23 (2017).
-
(2017)
Cell
, vol.169
, pp. 13-23
-
-
Hnisz, D.1
Shrinivas, K.2
Young, R.A.3
Chakraborty, A.K.4
Sharp, P.A.A.5
-
130
-
-
84890062562
-
Model of the mediator middle module based on protein cross-linking
-
Lariviere, L. et al. Model of the Mediator middle module based on protein cross-linking. Nucleic Acids Res. 41, 9266-9273 (2013).
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 9266-9273
-
-
Lariviere, L.1
-
131
-
-
34848913963
-
Evolution of protein complexes by duplication of homomeric interactions
-
Pereira-Leal, J. B., Levy, E. D., Kamp, C. & Teichmann, S. A. Evolution of protein complexes by duplication of homomeric interactions. Genome Biol. 8, R51 (2007).
-
(2007)
Genome Biol.
, vol.8
, pp. R51
-
-
Pereira-Leal, J.B.1
Levy, E.D.2
Kamp, C.3
Teichmann, S.A.4
-
132
-
-
80051729454
-
Mediator head subcomplex med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization
-
Seizl, M., Lariviere, L., Pfaffeneder, T., Wenzeck, L. & Cramer, P. Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization. Nucleic Acids Res. 39, 6291-6304 (2011).
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 6291-6304
-
-
Seizl, M.1
Lariviere, L.2
Pfaffeneder, T.3
Wenzeck, L.4
Cramer, P.5
-
133
-
-
34047153922
-
A recurrent mutation in med12 leading to r961w causes opitz-kaveggia syndrome
-
Risheg, H. et al. A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome. Nat. Genet. 39, 451-453 (2007).
-
(2007)
Nat. Genet.
, vol.39
, pp. 451-453
-
-
Risheg, H.1
-
134
-
-
34447342555
-
The original lujan syndrome family has a novel missense mutation (p. N1007s) in the med12 gene
-
Schwartz, C. E. et al. The original Lujan syndrome family has a novel missense mutation (p. N1007S) in the MED12 gene. J. Med. Genet. 44, 472-477 (2007).
-
(2007)
J. Med. Genet.
, vol.44
, pp. 472-477
-
-
Schwartz, C.E.1
-
135
-
-
78249244149
-
Infantile cerebral and cerebellar atrophy is associated with a mutation in the med17 subunit of the transcription preinitiation mediator complex
-
Kaufmann, R. et al. Infantile cerebral and cerebellar atrophy is associated with a mutation in the MED17 subunit of the transcription preinitiation mediator complex. Am. J. Hum. Genet. 87, 667-670 (2010).
-
(2010)
Am. J. Hum. Genet.
, vol.87
, pp. 667-670
-
-
Kaufmann, R.1
-
136
-
-
80052170163
-
Med23 mutation links intellectual disability to dysregulation of immediate early gene expression
-
Hashimoto, S. et al. MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. Science 333, 1161-1163 (2011).
-
(2011)
Science
, vol.333
, pp. 1161-1163
-
-
Hashimoto, S.1
-
137
-
-
80053309555
-
Med29, a component of the mediator complex, possesses both oncogenic and tumor suppressive characteristics in pancreatic cancer
-
Kuuselo, R., Savinainen, K., Sandstrom, S., Autio, R. & Kallioniemi, A. MED29, a component of the mediator complex, possesses both oncogenic and tumor suppressive characteristics in pancreatic cancer. Int. J. Cancer 129, 2553-2565 (2011).
-
(2011)
Int. J. Cancer
, vol.129
, pp. 2553-2565
-
-
Kuuselo, R.1
Savinainen, K.2
Sandstrom, S.3
Autio, R.4
Kallioniemi, A.5
-
138
-
-
34249327738
-
A coregulatory role for the mediator complex in prostate cancer cell proliferation and gene expression
-
Vijayvargia, R., May, M. S. & Fondell, J. D. A coregulatory role for the mediator complex in prostate cancer cell proliferation and gene expression. Cancer Res. 67, 4034-4041 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 4034-4041
-
-
Vijayvargia, R.1
May, M.S.2
Fondell, J.D.3
-
139
-
-
79959601916
-
Lentivirus-mediated inhibition of med19 suppresses growth of breast cancer cells in vitro
-
Li, L. H., He, J., Hua, D., Guo, Z. J. & Gao, Q. Lentivirus-mediated inhibition of Med19 suppresses growth of breast cancer cells in vitro. Cancer Chemother. Pharmacol. 68, 207-215 (2011).
-
(2011)
Cancer Chemother. Pharmacol.
, vol.68
, pp. 207-215
-
-
Li, L.H.1
He, J.2
Hua, D.3
Guo, Z.J.4
Gao, Q.5
-
140
-
-
0033587187
-
Mammalian srb/mediator complex is targeted by adenovirus e1a protein
-
Boyer, T. G., Martin, M. E., Lees, E., Ricciardi, R. P. & Berk, A. J. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. Nature 399, 276-279 (1999).
-
(1999)
Nature
, vol.399
, pp. 276-279
-
-
Boyer, T.G.1
Martin, M.E.2
Lees, E.3
Ricciardi, R.P.4
Berk, A.J.5
-
141
-
-
39349097864
-
Identification of host proteins required for HIV infection through a functional genomic screen
-
Brass, A. L. et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science 319, 921-926 (2008).
-
(2008)
Science
, vol.319
, pp. 921-926
-
-
Brass, A.L.1
-
142
-
-
67249143012
-
Host cell factors in HIV replication: Meta-Analysis of genome-wide studies
-
Bushman, F. D. et al. Host cell factors in HIV replication: Meta-Analysis of genome-wide studies. PLoS Pathog. 5, e1000437 (2009).
-
(2009)
PLoS Pathog.
, vol.5
, pp. e1000437
-
-
Bushman, F.D.1
-
143
-
-
0037370376
-
Principal role of trap/mediator and swi/snf complexes in kaposi's sarcoma-Associated herpesvirus rta-mediated lytic reactivation
-
Gwack, Y. et al. Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-Associated herpesvirus RTA-mediated lytic reactivation. Mol. Cell. Biol. 23, 2055-2067 (2003).
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 2055-2067
-
-
Gwack, Y.1
-
144
-
-
79953779234
-
Structure of the vp16 transactivator target in the mediator
-
Milbradt, A. G. et al. Structure of the VP16 transactivator target in the Mediator. Nat. Struct. Mol. Biol. 18, 410-415 (2011).
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 410-415
-
-
Milbradt, A.G.1
-
145
-
-
0346993714
-
A novel docking site on mediator is critical for activation by vp16 in mammalian cells
-
Mittler, G. et al. A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. EMBO J. 22, 6494-6504 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 6494-6504
-
-
Mittler, G.1
-
146
-
-
79953770655
-
Structure and vp16 binding of the mediator med25 activator interaction domain
-
Vojnic, E. et al. Structure and VP16 binding of the Mediator Med25 activator interaction domain. Nat. Struct. Mol. Biol. 18, 404-409 (2011).
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 404-409
-
-
Vojnic, E.1
-
147
-
-
84974806738
-
Eukaryotic transcription regulation: Getting to the heart of the matter: Commentary on mediator architecture and RNA polymerase II function by plaschka et al
-
Malik, S. Eukaryotic Transcription regulation: Getting to the heart of the matter: Commentary on Mediator architecture and RNA polymerase II function by Plaschka et al. J. Mol. Biol. 428, 2575-2580 (2016).
-
(2016)
J. Mol. Biol.
, vol.428
, pp. 2575-2580
-
-
Malik, S.1
|