-
1
-
-
0034644526
-
Linking colorectal cancer to Wnt signaling
-
Bienz, M. & Clevers, H. Linking colorectal cancer to Wnt signaling. Cell 103, 311-320 (2000).
-
(2000)
Cell
, vol.103
, pp. 311-320
-
-
Bienz, M.1
Clevers, H.2
-
2
-
-
0036852721
-
Automated subcellular localization and quantification of protein expression in tissue microarrays
-
Camp, R. L., Chung, G. G. & Rimm, D. L. Automated subcellular localization and quantification of protein expression in tissue microarrays. Nature Med. 8, 1323-1327 (2002).
-
(2002)
Nature Med
, vol.8
, pp. 1323-1327
-
-
Camp, R.L.1
Chung, G.G.2
Rimm, D.L.3
-
3
-
-
0023748414
-
Genetic alterations during colorectal-tumor development
-
Vogelstein, B. et al. Genetic alterations during colorectal-tumor development. N. Engl. J. Med. 319, 525-532 (1988).
-
(1988)
N. Engl. J. Med
, vol.319
, pp. 525-532
-
-
Vogelstein, B.1
-
4
-
-
18844378166
-
The mammalian Mediator complex and its role in transcriptional regulation
-
Conaway, R. C., Sato, S., Tomomori-Sato, C., Yao, T. & Conaway, J. W. The mammalian Mediator complex and its role in transcriptional regulation. Trends Biochem. Sci. 30, 250-255 (2005).
-
(2005)
Trends Biochem. Sci
, vol.30
, pp. 250-255
-
-
Conaway, R.C.1
Sato, S.2
Tomomori-Sato, C.3
Yao, T.4
Conaway, J.W.5
-
5
-
-
0037047057
-
Mutations in APC, Kirsten-ras, and p53 - alternative genetic pathways to colorectal cancer
-
Smith, G. et al. Mutations in APC, Kirsten-ras, and p53 - alternative genetic pathways to colorectal cancer. Proc. Natl Acad. Sci. USA 99, 9433-9438 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 9433-9438
-
-
Smith, G.1
-
6
-
-
18644373146
-
The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
-
van de Wetering, M. et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111, 241-250 (2002).
-
(2002)
Cell
, vol.111
, pp. 241-250
-
-
van de Wetering, M.1
-
7
-
-
33646033137
-
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
-
Moffat, J. et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124, 1283-1298 (2006).
-
(2006)
Cell
, vol.124
, pp. 1283-1298
-
-
Moffat, J.1
-
8
-
-
0030975671
-
-/- colon carcinoma
-
-/- colon carcinoma. Science 275, 1784-1787 (1997).
-
(1997)
Science
, vol.275
, pp. 1784-1787
-
-
Korinek, V.1
-
9
-
-
28644444440
-
Casein kinase 1γ couples Wnt receptor activation to cytoplasmic signal transduction
-
Davidson, G. et al. Casein kinase 1γ couples Wnt receptor activation to cytoplasmic signal transduction. Nature 438, 867-872 (2005).
-
(2005)
Nature
, vol.438
, pp. 867-872
-
-
Davidson, G.1
-
10
-
-
0037900076
-
Casein kinase Iε enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of β-catenin
-
Hino, S., Michiue, T., Asashima, M. & Kikuchi, A. Casein kinase Iε enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of β-catenin. J. Biol. Chem. 278, 14066-14073 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 14066-14073
-
-
Hino, S.1
Michiue, T.2
Asashima, M.3
Kikuchi, A.4
-
11
-
-
38049100456
-
Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma
-
Beroukhim, R. et al. Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc. Natl Acad. Sci. USA 104, 20007-20012 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 20007-20012
-
-
Beroukhim, R.1
-
12
-
-
36248980204
-
Characterizing the cancer genome in lung adenocarcinoma
-
Weir, B. A. et al. Characterizing the cancer genome in lung adenocarcinoma. Nature 450, 893-898 (2007).
-
(2007)
Nature
, vol.450
, pp. 893-898
-
-
Weir, B.A.1
-
13
-
-
36348970735
-
Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types
-
Martin, E. S. et al. Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Res. 67, 10736-10743 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 10736-10743
-
-
Martin, E.S.1
-
14
-
-
33644547983
-
Relationship of gene expression and chromosomal abnormalities in colorectal cancer
-
Tsafrir, D. et al. Relationship of gene expression and chromosomal abnormalities in colorectal cancer. Cancer Res. 66, 2129-2137 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 2129-2137
-
-
Tsafrir, D.1
-
15
-
-
52949093102
-
-
E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8, doi:10.1038/nature07310 this issue
-
Morris E. J. . et al. E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8. Nature doi:10.1038/nature07310 (this issue).
-
Nature
-
-
Morris, E.J.1
-
16
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
-
17
-
-
21844478747
-
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
-
Garraway, L. A. et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436, 117-122 (2005).
-
(2005)
Nature
, vol.436
, pp. 117-122
-
-
Garraway, L.A.1
-
18
-
-
0032529484
-
Targeting of CDK8 to a promoter-proximal RNA element demonstrates catalysis-dependent activation of gene expression
-
Gold, M. O. & Rice, A. P. Targeting of CDK8 to a promoter-proximal RNA element demonstrates catalysis-dependent activation of gene expression. Nucleic Acids Res. 26, 3784-3788 (1998).
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 3784-3788
-
-
Gold, M.O.1
Rice, A.P.2
-
19
-
-
0030923587
-
β-Catenin mutations in cell lines established from human colorectal cancers
-
Ilyas, M., Tomlinson, I. P., Rowan, A., Pignatelli, M. & Bodmer, W. F. β-Catenin mutations in cell lines established from human colorectal cancers. Proc. Natl Acad. Sci. USA 94, 10330-10334 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 10330-10334
-
-
Ilyas, M.1
Tomlinson, I.P.2
Rowan, A.3
Pignatelli, M.4
Bodmer, W.F.5
-
20
-
-
0032521433
-
Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer
-
Sparks, A. B., Morin, P. J., Vogelstein, B. & Kinzler, K. W. Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer. Cancer Res. 58, 1130-1134 (1998).
-
(1998)
Cancer Res
, vol.58
, pp. 1130-1134
-
-
Sparks, A.B.1
Morin, P.J.2
Vogelstein, B.3
Kinzler, K.W.4
-
21
-
-
0034724186
-
APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits
-
Rowan, A. J. et al. APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits". Proc. Natl Acad. Sci. USA 97, 3352-3357 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 3352-3357
-
-
Rowan, A.J.1
-
22
-
-
0029083795
-
Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C
-
Tassan, J. P., Jaquenoud, M., Leopold, P., Schultz, S. J. & Nigg, E. A. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. Proc. Natl Acad. Sci. USA 92, 8871-8875 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 8871-8875
-
-
Tassan, J.P.1
Jaquenoud, M.2
Leopold, P.3
Schultz, S.J.4
Nigg, E.A.5
-
23
-
-
34247187543
-
Myc deletion rescues Apc deficiency in the small intestine
-
Sansom, O. J. et al. Myc deletion rescues Apc deficiency in the small intestine. Nature 446, 676-679 (2007).
-
(2007)
Nature
, vol.446
, pp. 676-679
-
-
Sansom, O.J.1
-
24
-
-
0035913994
-
Constitutive activation of Wnt/β-catenin signaling pathway in migration-active melanoma cells: Role of LEF-1 in melanoma with increased metastatic potential
-
Murakami, T. et al. Constitutive activation of Wnt/β-catenin signaling pathway in migration-active melanoma cells: role of LEF-1 in melanoma with increased metastatic potential. Biochem. Biophys. Res. Commun. 288, 8-15 (2001).
-
(2001)
Biochem. Biophys. Res. Commun
, vol.288
, pp. 8-15
-
-
Murakami, T.1
-
25
-
-
0032483439
-
Identification of c-MYC as a target of the APC pathway
-
He, T. C. et al. Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1512 (1998).
-
(1998)
Science
, vol.281
, pp. 1509-1512
-
-
He, T.C.1
-
26
-
-
8844229536
-
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
-
Fryer, C. J., White, J. B. & Jones, K. A. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol. Cell 16, 509-520 (2004).
-
(2004)
Mol. Cell
, vol.16
, pp. 509-520
-
-
Fryer, C.J.1
White, J.B.2
Jones, K.A.3
-
27
-
-
33751514601
-
A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells
-
Yook, J. I. et al. A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells. Nature Cell Biol. 8, 1398-1406 (2006).
-
(2006)
Nature Cell Biol
, vol.8
, pp. 1398-1406
-
-
Yook, J.I.1
-
28
-
-
33746944018
-
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1
-
Chiang, M. Y. et al. Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol. Cell. Biol. 26, 6261-6271 (2006).
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 6261-6271
-
-
Chiang, M.Y.1
-
29
-
-
0032801892
-
Neoplastic transformation of RK3E by mutant β-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression
-
Kolligs, F. T., Hu, G., Dang, C. V. & Fearon, E. R. Neoplastic transformation of RK3E by mutant β-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression. Mol. Cell. Biol. 19, 5696-5706 (1999).
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 5696-5706
-
-
Kolligs, F.T.1
Hu, G.2
Dang, C.V.3
Fearon, E.R.4
-
30
-
-
34249993765
-
Integrative genomic approaches identify IKBKE as a breast cancer oncogene
-
Boehm, J. S. et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell 129, 1065-1079 (2007).
-
(2007)
Cell
, vol.129
, pp. 1065-1079
-
-
Boehm, J.S.1
-
31
-
-
38049100456
-
Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma
-
Beroukhim, R. et al. Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc. Natl Acad. Sci. USA 104, 20007-20012 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 20007-20012
-
-
Beroukhim, R.1
-
32
-
-
0035801388
-
Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation
-
Damalas, A. et al. Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J. 20, 4912-4922 (2001).
-
(2001)
EMBO J
, vol.20
, pp. 4912-4922
-
-
Damalas, A.1
-
33
-
-
36248980204
-
Characterizing the cancer genome in lung adenocarcinoma
-
Weir, B. A. et al. Characterizing the cancer genome in lung adenocarcinoma. Nature 450, 893-898 (2007).
-
(2007)
Nature
, vol.450
, pp. 893-898
-
-
Weir, B.A.1
|